TB-Profiler result

Run: SRR1167055
Summary

Run ID: SRR1167055

Sample name:

Date: 2024-10-05T14:17:26.590525

Number of reads: 6433465

Percentage reads mapped: 84.51

Median coverage: 140.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.98
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.97
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5815 c.576C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 5824 c.585A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 5827 c.588G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 5848 c.609G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 5863 c.624G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 5873 c.634A>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6123 p.Ala295Gly missense_variant 0.16 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6133 c.894G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6148 c.909C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6169 c.930C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6209 c.970C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.15 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.13 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.16 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7523 c.222C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7710 c.409T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7923 p.His208Tyr missense_variant 0.12 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8093 c.792C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 p.Ile328Leu missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8348 c.1047C>A synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8363 c.1062C>A synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Pro missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>T synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9311 c.2010C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
fgd1 491286 c.504G>C synonymous_variant 0.16 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491591 p.Lys270Met missense_variant 0.9 pretomanid
delamanid Uncertain significance
clofazimine Not assoc w R
mshA 575679 p.Asn111Ser missense_variant 0.96 isoniazid Not assoc w R
ethionamide Not assoc w R
Rv0565c 657269 p.Ser68Pro missense_variant 0.94 ethionamide Uncertain significance
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.15 ethionamide
hadA 731792 c.-138G>A upstream_gene_variant 0.13 isoniazid
nusG 734532 c.279A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.14 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.9 rifampicin Not assoc w R
rpoB 760181 c.375T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.24 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.2 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.18 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.18 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.17 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.17 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.17 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.14 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.14 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.17 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.15 rifampicin
rpoB 760845 p.Thr347Pro missense_variant 0.16 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.16 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.2 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.2 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.22 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.21 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.2 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.22 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.23 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>A synonymous_variant 0.21 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.15 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.18 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.19 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.2 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761297 c.1491C>T synonymous_variant 0.2 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761360 c.1554T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.15 rifampicin
rpoB 761374 p.Val523Glu missense_variant 0.13 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.14 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.16 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.16 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.17 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.18 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.17 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762131 c.2325C>G synonymous_variant 0.14 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.2 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.18 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.19 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.17 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.17 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.17 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.17 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.17 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.14 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.14 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>T upstream_gene_variant 0.16 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.15 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.21 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.18 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.2 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.19 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.21 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.21 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCC upstream_gene_variant 0.21 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.23 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.14 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.16 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.21 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTTG synonymous_variant 0.18 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.15 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.19 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.21 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.19 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.17 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.19 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.18 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.22 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.22 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.2 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.23 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.24 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.24 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.26 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.21 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.16 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.18 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.2 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.22 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.23 rifampicin
rpoC 763919 c.550C>T synonymous_variant 0.21 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.15 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.13 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.14 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.22 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.16 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.16 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.15 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.15 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.14 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.2 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.18 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 0.18 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.21 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTTG synonymous_variant 0.2 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.2 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.19 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764714 c.1345C>T synonymous_variant 0.24 rifampicin
rpoC 764720 c.1351C>T synonymous_variant 0.21 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.19 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.21 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.19 rifampicin
rpoC 764872 c.1503A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.14 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.14 rifampicin Not assoc w R
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765349 c.1980T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.17 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.18 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.18 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.18 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.15 rifampicin
rpoC 765452 p.Ala695Ser missense_variant 0.15 rifampicin
rpoC 765493 c.2124G>C synonymous_variant 0.14 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.16 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.16 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.17 rifampicin
rpoC 765577 c.2208G>C synonymous_variant 0.16 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.15 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.16 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.17 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.16 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.17 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.16 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.15 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.14 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.27 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.26 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.15 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766043 p.Gln892Glu missense_variant 0.14 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.16 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.17 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.18 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.17 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.14 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 766381 c.3012C>T synonymous_variant 0.13 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.14 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.14 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 766543 c.3174C>T synonymous_variant 0.14 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.18 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.17 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.16 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.15 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.18 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.24 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.2 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.18 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.18 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.19 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.22 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.23 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766769 c.3400C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.2 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.2 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.21 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.2 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.2 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.21 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.19 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767033 p.Ser1222Thr missense_variant 0.14 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.17 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.2 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.21 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.22 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.19 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.17 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781608 p.Ser17Gly missense_variant 0.16 streptomycin
rpsL 781631 c.72G>C synonymous_variant 0.24 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.21 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.21 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.19 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.19 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.18 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.18 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.19 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.19 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.2 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.2 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.23 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.22 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.2 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.21 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.21 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.2 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.19 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.19 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.17 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.17 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.18 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.18 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.2 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.21 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.18 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.16 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.16 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.17 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.15 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.16 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.15 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.15 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.13 linezolid
rplC 800814 c.6A>G synonymous_variant 0.14 linezolid
rplC 800817 c.9A>T synonymous_variant 0.15 linezolid
rplC 800844 c.36T>C synonymous_variant 0.13 linezolid
fbiC 1303854 c.924T>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303923 c.993C>T synonymous_variant 0.13 pretomanid
delamanid
clofazimine
fbiC 1303969 p.Val347Ile missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303973 p.Gly348Ala missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303981 p.Val351Ile missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303995 c.1065C>T synonymous_variant 0.15 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304008 c.1078T>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.13 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304925 c.1995G>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1305381 c.2451G>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1305393 c.2463T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1305405 c.2475A>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine Not assoc w R - Interim
fbiC 1305430 p.Val834Ile missense_variant 0.12 pretomanid
delamanid
clofazimine
atpE 1461132 p.Val30Ile missense_variant 0.13 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.15 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.15 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.19 bedaquiline Uncertain significance
atpE 1461185 c.141G>C synonymous_variant 0.18 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.18 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.18 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.17 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.18 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.18 bedaquiline
atpE 1461233 c.189A>G synonymous_variant 0.14 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475271 n.1614A>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475273 n.1616T>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.16 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.27 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
inhA 1674624 c.423A>C synonymous_variant 0.14 isoniazid
ethionamide
inhA 1674627 c.426T>G synonymous_variant 0.14 isoniazid
ethionamide
rpsA 1833661 c.120A>G synonymous_variant 0.14 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.16 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.16 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.16 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.14 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834594 c.1053C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834622 p.Ser361Thr missense_variant 0.13 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917934 c.-6T>C upstream_gene_variant 1.0 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2063642 p.Asp363Tyr missense_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
katG 2155632 c.480A>C synonymous_variant 0.17 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.18 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.19 isoniazid Uncertain significance
katG 2155677 c.435C>G synonymous_variant 0.17 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.17 isoniazid
PPE35 2170173 c.437_439dupTGG conservative_inframe_insertion 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517947 c.-168C>T upstream_gene_variant 0.17 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.15 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.14 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.16 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.15 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.13 isoniazid
folC 2747355 p.Val82Ile missense_variant 0.13 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.14 para-aminosalicylic_acid
Rv2477c 2782510 c.1533G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783015 p.Ser343Thr missense_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.18 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783110 c.933C>A synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.14 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783920 c.123G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.15 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.17 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.15 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2752c 3065687 p.Gly169Ser missense_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyA 3073926 c.546G>C synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074010 c.462C>A synonymous_variant 0.13 para-aminosalicylic_acid
thyA 3074155 p.Gly106Asp missense_variant 0.91 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625627 c.-717C>T upstream_gene_variant 0.13 rifampicin
bedaquiline
lpqB 3625648 c.-738T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625669 c.-759G>C upstream_gene_variant 0.13 rifampicin
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.13 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3626942 c.-329A>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627139 c.-526T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627170 c.-557C>G upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.13 rifampicin
bedaquiline
rpoA 3877553 p.Glu319Gln missense_variant 0.15 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.17 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.15 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.15 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.17 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.18 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.18 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878118 c.390T>C synonymous_variant 0.14 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.15 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.15 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.16 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.14 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.15 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.14 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.14 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.14 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.18 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.16 rifampicin
clpC1 4038244 p.Thr821Ala missense_variant 0.17 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.15 pyrazinamide
clpC1 4038272 p.Gly811Ser missense_variant 0.15 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038308 p.Val799Ile missense_variant 0.19 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.15 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.14 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.18 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.14 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.14 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.14 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038740 c.1965G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.17 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039268 c.1437C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039388 c.1317C>A synonymous_variant 0.17 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.16 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.16 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.14 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.18 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.22 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.25 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.22 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.14 pyrazinamide
clpC1 4040264 c.441C>T synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.15 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.14 pyrazinamide
clpC1 4040459 c.246C>G synonymous_variant 0.13 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>A synonymous_variant 0.15 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
glpK 4139575 p.Val61Ile missense_variant 0.12 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139630 c.126C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4239298 c.-565C>T upstream_gene_variant 0.99 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
embB 4247470 c.957T>C synonymous_variant 0.14 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.14 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.15 ethambutol
embB 4248095 c.1582_1584delCTCinsTTG synonymous_variant 0.17 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.21 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.2 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.21 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.19 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.19 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4248206 p.Ser565Gly missense_variant 0.18 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.18 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.15 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.15 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin