TB-Profiler result

Run: SRR26399265
Summary

Run ID: SRR26399265

Sample name:

Date: 2025-02-11T14:58:36.116464

Number of reads: 1639422

Percentage reads mapped: 87.87

Median coverage: 48.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.93
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.99
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.514A>C Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472359 n.514A>C non_coding_transcript_exon_variant 0.49 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1047 c.1047A>G synonymous_variant 0.26 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.24 isoniazid
dnaA 1074 c.1074C>A synonymous_variant 0.23 isoniazid
dnaA 1080 c.1080C>G synonymous_variant 0.24 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 1104 c.1104T>C synonymous_variant 0.23 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.21 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.21 isoniazid
dnaA 1128 c.1128G>C synonymous_variant 0.2 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.22 isoniazid
gyrB 6265 c.1026C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6673 c.-629A>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6715 c.1476C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6730 c.-572A>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6794 p.Ile519Leu missense_variant 0.25 levofloxacin
moxifloxacin
gyrB 6797 p.Gly520Thr missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 7096 c.-206G>A upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7120 c.-182T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7156 c.1917C>T synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7177 c.-125G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7213 c.-89G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 7216 c.1977G>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7225 c.-77T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7243 c.-59G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7415 c.114C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7421 c.120G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7433 c.132G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7475 c.174A>G synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.46 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7496 c.195C>A synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7587 c.286C>T synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7619 c.318C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7626 c.325C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8456 c.1155C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8522 c.1221G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8555 c.1254G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8765 p.Asp488Glu missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8767 p.Arg489Lys missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8790 c.1489C>A synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8796 p.Ile499Val missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8813 p.Asp504Glu missense_variant 0.33 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8818 p.Ser506Asn missense_variant 0.33 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8829 c.1528T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9275 c.1974G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9284 c.1983T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9287 c.1986G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 9565 p.Tyr755Phe missense_variant 0.18 levofloxacin
moxifloxacin
fgd1 491514 p.Asn244Lys missense_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491526 c.744T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491542 c.760T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fgd1 491547 c.765A>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491550 c.768T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491601 c.819T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575576 c.229C>T synonymous_variant 0.22 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575587 c.240C>G synonymous_variant 0.22 isoniazid
ethionamide
mshA 575590 c.243T>G synonymous_variant 0.24 isoniazid
ethionamide
mshA 575620 c.273G>T synonymous_variant 0.27 isoniazid
ethionamide
mshA 575629 c.282A>C synonymous_variant 0.28 isoniazid
ethionamide
mshA 575632 c.285G>C synonymous_variant 0.28 isoniazid
ethionamide
mshA 575635 c.288A>C synonymous_variant 0.3 isoniazid Not assoc w R - Interim
ethionamide
mshA 575638 c.291T>C synonymous_variant 0.29 isoniazid
ethionamide
mshA 575649 p.Val101Ala missense_variant 0.35 isoniazid
ethionamide
mshA 575659 c.312A>G synonymous_variant 0.38 isoniazid
ethionamide
mshA 575665 c.318G>C synonymous_variant 0.4 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575695 c.348C>G synonymous_variant 0.43 isoniazid Not assoc w R - Interim
ethionamide
mshA 575704 c.357T>C synonymous_variant 0.42 isoniazid
ethionamide
mshA 575705 c.358T>C synonymous_variant 0.41 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.37 isoniazid
ethionamide
mshA 575728 c.381C>G synonymous_variant 0.32 isoniazid
ethionamide
mshA 575734 c.387T>G synonymous_variant 0.31 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.31 isoniazid
ethionamide
mshA 575740 c.393G>A synonymous_variant 0.32 isoniazid
ethionamide
mshA 575752 c.405G>T synonymous_variant 0.29 isoniazid
ethionamide
mshA 575764 c.417C>G synonymous_variant 0.3 isoniazid
ethionamide
mshA 575771 p.Val142Ser missense_variant 0.28 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.28 isoniazid
ethionamide
mshA 575786 p.Tyr147His missense_variant 0.27 isoniazid
ethionamide
mshA 575907 p.Ala187Val missense_variant 0.89 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620241 c.351C>G synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620245 p.Leu119Met missense_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620249 p.Ser120Cys missense_variant 0.38 kanamycin
capreomycin
amikacin
ccsA 620256 c.366C>G synonymous_variant 0.36 kanamycin
capreomycin
amikacin
ccsA 620257 p.Ile123Leu missense_variant 0.36 kanamycin
capreomycin
amikacin
ccsA 620269 p.Val127Phe missense_variant 0.43 kanamycin
capreomycin
amikacin
ccsA 620283 c.393T>C synonymous_variant 0.42 kanamycin
capreomycin
amikacin
ccsA 620284 p.Ala132Pro missense_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620288 p.Arg133Gln missense_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620295 c.405G>C synonymous_variant 0.44 kanamycin
capreomycin
amikacin
ccsA 620319 c.429C>G synonymous_variant 0.41 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.46 kanamycin
capreomycin
amikacin
ccsA 620349 c.459A>G synonymous_variant 0.49 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.5 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.52 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.46 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.43 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.43 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.38 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620433 c.543C>G synonymous_variant 0.31 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620436 c.546T>C synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620439 c.549T>C synonymous_variant 0.31 kanamycin
capreomycin
amikacin
ccsA 620445 c.555A>G synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620449 p.Leu187Met missense_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620454 c.564C>G synonymous_variant 0.31 kanamycin
capreomycin
amikacin
ccsA 620460 c.570T>C synonymous_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620461 p.Val191Ile missense_variant 0.27 kanamycin
capreomycin
amikacin
ccsA 620604 c.714C>G synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620607 c.717T>G synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620613 c.723C>T synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620625 c.735A>C synonymous_variant 0.28 kanamycin
capreomycin
amikacin
ccsA 620625 p.Ile245Met missense_variant 0.7 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
ccsA 620631 c.741T>C synonymous_variant 0.33 kanamycin
capreomycin
amikacin
ccsA 620634 c.744C>G synonymous_variant 0.33 kanamycin
capreomycin
amikacin
ccsA 620643 c.753C>G synonymous_variant 0.31 kanamycin
capreomycin
amikacin
ccsA 620649 c.759A>G synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620652 c.762C>G synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620658 c.768C>T synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620661 c.771C>G synonymous_variant 0.32 kanamycin
capreomycin
amikacin
ccsA 620664 c.774C>T synonymous_variant 0.34 kanamycin
capreomycin
amikacin
ccsA 620688 c.798G>C synonymous_variant 0.36 kanamycin
capreomycin
amikacin
ccsA 620703 c.813G>C synonymous_variant 0.4 kanamycin
capreomycin
amikacin
ccsA 620710 p.Val274Ile missense_variant 0.38 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.43 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.37 kanamycin
capreomycin
amikacin
ccsA 620734 c.844C>A synonymous_variant 0.37 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.36 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>C synonymous_variant 0.33 kanamycin
capreomycin
amikacin
ccsA 620758 c.868_870delCGCinsAGG synonymous_variant 0.29 kanamycin
capreomycin
amikacin
ccsA 620766 c.876C>G synonymous_variant 0.3 kanamycin
capreomycin
amikacin
ccsA 620778 c.888T>C synonymous_variant 0.26 kanamycin
capreomycin
amikacin
ccsA 620787 c.897C>G synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620823 c.933C>T synonymous_variant 0.17 kanamycin
capreomycin
amikacin
Rv0565c 657081 c.390G>A synonymous_variant 0.98 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.9 ethionamide Uncertain significance
Rv0565c 657291 c.180C>G synonymous_variant 0.23 ethionamide
Rv0565c 657294 c.177C>T synonymous_variant 0.22 ethionamide
Rv0565c 657679 c.-209A>G upstream_gene_variant 0.2 ethionamide
Rv0565c 657689 c.-219A>C upstream_gene_variant 0.19 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.18 ethionamide
Rv0565c 657724 c.-254A>C upstream_gene_variant 0.18 ethionamide
hadA 731686 c.-244_-243insCT upstream_gene_variant 0.22 isoniazid
hadA 731693 c.-237C>T upstream_gene_variant 0.22 isoniazid
hadA 731694 c.-235_-234delCG upstream_gene_variant 0.23 isoniazid
hadA 731698 c.-232T>G upstream_gene_variant 0.23 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.22 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.22 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.22 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.22 isoniazid
hadA 732209 p.Glu94Lys missense_variant 0.18 isoniazid
hadA 732212 p.Lys95Ala missense_variant 0.18 isoniazid
hadA 732223 c.294G>C synonymous_variant 0.21 isoniazid
hadA 732252 p.Tyr108Ser missense_variant 0.2 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.26 isoniazid
nusG 734147 c.-107T>C upstream_gene_variant 0.35 rifampicin
nusG 734173 c.-81C>G upstream_gene_variant 0.36 rifampicin
nusG 734175 c.-79_-77delGGTinsCTC upstream_gene_variant 0.38 rifampicin
nusG 734180 c.-74T>G upstream_gene_variant 0.36 rifampicin Uncertain significance
nusG 734183 c.-71C>T upstream_gene_variant 0.36 rifampicin
nusG 734186 c.-68G>C upstream_gene_variant 0.36 rifampicin Uncertain significance
nusG 734192 c.-62G>C upstream_gene_variant 0.38 rifampicin
nusG 734205 c.-49A>C upstream_gene_variant 0.38 rifampicin
nusG 734208 c.-46T>C upstream_gene_variant 0.39 rifampicin
nusG 734223 c.-30_-28delGCT upstream_gene_variant 0.37 rifampicin
nusG 734232 c.-22_-21delGTinsA upstream_gene_variant 0.36 rifampicin
nusG 734236 c.-18C>T upstream_gene_variant 0.36 rifampicin
nusG 734407 p.Val52Ile missense_variant 0.23 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.26 rifampicin
nusG 734424 c.171G>C synonymous_variant 0.25 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.29 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.3 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.28 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.29 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.31 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.41 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.3 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734812 p.Val187Leu missense_variant 0.6 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.19 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760381 p.Thr192Met missense_variant 0.18 rifampicin
rpoB 760646 c.840C>A synonymous_variant 0.23 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.24 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.24 rifampicin Uncertain significance
rpoB 760919 c.1113C>G synonymous_variant 0.23 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.24 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>G synonymous_variant 0.23 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.31 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.31 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.18 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763636 c.267T>C synonymous_variant 0.24 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>T synonymous_variant 0.22 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.22 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.19 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.2 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.24 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.25 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.26 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.26 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.28 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.31 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.29 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.28 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.29 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.3 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.29 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.3 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.29 rifampicin
rpoC 763912 c.543G>C synonymous_variant 0.26 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.2 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764044 c.675T>C synonymous_variant 0.2 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.2 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.21 rifampicin
rpoC 764095 c.726C>G synonymous_variant 0.21 rifampicin
rpoC 764101 c.732C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.23 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.24 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.2 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.18 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 0.97 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781655 c.96T>C synonymous_variant 0.17 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.17 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.32 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.33 streptomycin
rpsL 781706 c.147T>G synonymous_variant 0.33 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.33 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.34 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.37 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.4 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.43 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.42 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.38 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.38 streptomycin
rpsL 781787 c.228G>A synonymous_variant 0.37 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.37 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.36 streptomycin
rpsL 781817 c.258G>A synonymous_variant 0.37 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.36 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.31 streptomycin Not assoc w R - Interim
rpsL 781841 c.282C>G synonymous_variant 0.3 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.34 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.33 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.33 streptomycin
rpsL 781877 c.318T>G synonymous_variant 0.33 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.3 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.29 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.39 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.42 streptomycin Uncertain significance
rplC 800901 c.93C>G synonymous_variant 0.19 linezolid
rplC 800916 c.108A>C synonymous_variant 0.23 linezolid
rplC 800937 c.129A>G synonymous_variant 0.26 linezolid
rplC 800946 c.138T>C synonymous_variant 0.24 linezolid
rplC 800949 c.141T>C synonymous_variant 0.25 linezolid
rplC 800970 c.162T>C synonymous_variant 0.18 linezolid Not assoc w R - Interim
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303779 c.849G>A synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303788 c.858T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303797 c.867A>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303809 c.879G>A synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303812 c.882C>T synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303851 c.921C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303855 p.Ala309Thr missense_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303869 c.939T>C synonymous_variant 0.22 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303884 c.954T>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303887 c.957G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303889 p.Val320Ala missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303897 c.967C>T synonymous_variant 0.24 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303905 c.975G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303908 c.978C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303921 p.Ile331Val missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304520 c.1590A>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304526 c.1596T>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304530 p.Ser534Ala missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304533 c.1603T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304544 c.1614T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304545 p.Val539Thr missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304571 c.1641G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304604 c.1674C>T synonymous_variant 0.2 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304757 c.1827A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304826 c.1896G>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>G synonymous_variant 0.33 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304847 c.1917C>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304856 c.1926C>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304880 c.1950C>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304896 c.1966C>T synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304922 c.1992C>T synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304931 c.2001C>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304940 c.2010A>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304949 c.2019C>T synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304955 c.2025G>A synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1305006 p.Glu692Asp missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305015 c.2085G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305033 c.2103T>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1305042 c.2112A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305045 c.2115A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
sigE 1364811 c.399A>G synonymous_variant 0.21 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.23 pyrazinamide
sigE 1364839 c.427_429delTTGinsCTC synonymous_variant 0.27 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.29 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.28 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.28 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.27 pyrazinamide
sigE 1364868 c.456T>C synonymous_variant 0.28 pyrazinamide
sigE 1364887 c.475_477delTTAinsCTG synonymous_variant 0.26 pyrazinamide
sigE 1364895 p.Glu161Asp missense_variant 0.28 pyrazinamide
sigE 1364898 c.486C>T synonymous_variant 0.28 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.31 pyrazinamide
sigE 1364916 c.504C>G synonymous_variant 0.28 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.28 pyrazinamide
sigE 1364952 c.540A>C synonymous_variant 0.24 pyrazinamide
sigE 1364958 c.546G>C synonymous_variant 0.19 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 0.98 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
atpE 1460840 c.-205A>G upstream_gene_variant 0.18 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.18 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.2 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.19 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.2 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.2 bedaquiline
atpE 1461158 c.114T>C synonymous_variant 0.2 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.2 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.2 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.22 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.22 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.22 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.19 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474431 n.774_775delGCinsTTTGGG non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474435 n.780_783delGAAT non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
inhA 1673574 c.-628C>G upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673580 c.-622T>C upstream_gene_variant 0.25 isoniazid Uncertain significance
ethionamide
inhA 1673583 c.-619A>C upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673589 c.-613A>G upstream_gene_variant 0.26 isoniazid
ethionamide
inhA 1673595 c.-607A>C upstream_gene_variant 0.27 isoniazid
ethionamide
inhA 1673596 c.-606A>G upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673607 c.-595T>C upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673615 c.-587_-586delAAinsTG upstream_gene_variant 0.27 isoniazid
ethionamide
inhA 1673619 c.-583T>C upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673633 c.-569G>A upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674627 c.426T>G synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674630 c.429C>G synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674639 c.438C>G synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674654 c.453G>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674660 c.459G>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674663 c.462G>C synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674669 c.468G>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674690 c.489C>G synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674708 c.507G>A synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674726 c.525G>C synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674729 c.528G>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674750 c.549T>G synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674756 c.555T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674771 c.570C>G synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674774 c.573A>G synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674780 c.579T>C synonymous_variant 0.22 isoniazid
ethionamide
rpsA 1833661 c.120A>G synonymous_variant 0.52 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.51 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.51 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.53 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.53 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.53 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.55 pyrazinamide
rpsA 1833754 c.213G>A synonymous_variant 0.55 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.5 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.49 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.46 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.46 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.46 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.49 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.55 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.56 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.55 pyrazinamide
rpsA 1833871 c.330G>A synonymous_variant 0.51 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.51 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.51 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.52 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.55 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.54 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.51 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.49 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.46 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.33 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.25 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.26 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834192 c.651C>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.39 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.47 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834351 c.810G>A synonymous_variant 0.4 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>G synonymous_variant 0.38 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.26 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834767 p.Lys409Thr missense_variant 0.25 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.26 pyrazinamide
tsnR 1853420 c.-186T>G upstream_gene_variant 0.19 linezolid
tsnR 1853429 c.-177G>T upstream_gene_variant 0.18 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155680 c.432G>C synonymous_variant 0.19 isoniazid
katG 2155696 p.Ala139Val missense_variant 0.22 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.17 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518146 p.Phe11Tyr missense_variant 0.23 isoniazid
kasA 2518265 p.Val51Ile missense_variant 0.19 isoniazid
kasA 2518279 c.165T>C synonymous_variant 0.21 isoniazid
kasA 2518282 c.168A>G synonymous_variant 0.2 isoniazid
kasA 2518283 p.Ala57Pro missense_variant 0.2 isoniazid
kasA 2518312 p.Asp66Glu missense_variant 0.25 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.2 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.25 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.24 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.25 isoniazid
kasA 2518588 c.474T>G synonymous_variant 0.24 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.24 isoniazid
kasA 2518597 c.483C>G synonymous_variant 0.24 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.21 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.2 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.21 isoniazid
folC 2747302 c.297A>G synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.19 para-aminosalicylic_acid
folC 2747326 c.273G>A synonymous_variant 0.22 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.22 para-aminosalicylic_acid
folC 2747371 c.228C>G synonymous_variant 0.2 para-aminosalicylic_acid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782495 p.Asp516Glu missense_variant 0.33 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol
amikacin Uncertain significance
Rv2477c 2782501 c.1542T>C synonymous_variant 0.36 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2782510 c.1533G>C synonymous_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.43 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.42 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782576 c.1467C>G synonymous_variant 0.44 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782582 p.Asn487Lys missense_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782586 p.Leu486Glu missense_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782591 c.1452T>G synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782594 c.1449T>C synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782612 c.1431T>G synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782621 c.1422T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782633 c.1410G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.21 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782960 c.1083C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.24 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.3 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783053 c.990C>T synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783476 c.567C>T synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.23 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783526 c.517C>T synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.26 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783569 c.474C>A synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783602 c.441G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783617 c.426G>A synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2681 2996353 c.-386G>C upstream_gene_variant 0.26 capreomycin
Rv2680 2996360 p.Met86Leu missense_variant 0.25 capreomycin
Rv2681 2996365 c.-374G>C upstream_gene_variant 0.24 capreomycin
Rv2681 2996368 c.-371T>C upstream_gene_variant 0.24 capreomycin
Rv2680 2996377 p.Asp91Glu missense_variant 0.24 capreomycin
Rv2680 2996381 p.Ser93Ala missense_variant 0.23 capreomycin
Rv2680 2996386 c.282T>C synonymous_variant 0.23 capreomycin Not assoc w R - Interim
Rv2681 2996389 c.-350A>G upstream_gene_variant 0.23 capreomycin
Rv2681 2996401 c.-338T>C upstream_gene_variant 0.23 capreomycin
Rv2681 2996404 c.-335T>C upstream_gene_variant 0.23 capreomycin
Rv2681 2996419 c.-320T>C upstream_gene_variant 0.23 capreomycin
Rv2680 2996420 p.Val106Ile missense_variant 0.23 capreomycin
Rv2681 2996431 c.-308C>T upstream_gene_variant 0.22 capreomycin
Rv2680 2996438 p.Ser112Pro missense_variant 0.21 capreomycin
Rv2680 2996442 p.Ser113Thr missense_variant 0.21 capreomycin
Rv2680 2996446 c.342A>G synonymous_variant 0.21 capreomycin Not assoc w R - Interim
Rv2681 2996467 c.-272C>G upstream_gene_variant 0.23 capreomycin
Rv2681 2996476 c.-263A>G upstream_gene_variant 0.19 capreomycin
Rv2752c 3065612 p.Thr194Ala missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065619 c.573C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065625 c.567G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065634 c.558G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065637 c.555A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065649 c.543T>G synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065658 p.Pro178Leu missense_variant 0.33 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3065661 c.531A>C synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065666 c.526T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065675 p.Phe173Leu missense_variant 0.34 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065699 p.Ile165Val missense_variant 0.29 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3065703 c.489A>C synonymous_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065715 p.Tyr159His missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065721 c.471G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065732 c.460T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065739 c.453G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065742 p.Thr150Ile missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066150 c.42C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066155 p.Ser13Thr missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066161 c.31C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066168 c.24A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066171 c.21G>T synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066176 p.Pro6Ala missense_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067259 c.687C>T synonymous_variant 0.53 para-aminosalicylic_acid
thyX 3067281 p.Val222Ala missense_variant 0.17 para-aminosalicylic_acid
thyX 3067304 c.642A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067321 c.625C>A synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067367 c.579G>A synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067379 c.567C>T synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067418 c.528C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067427 c.519G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067430 c.516C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067442 c.504C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067733 c.213G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067742 c.204A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067745 c.201C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.19 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.18 para-aminosalicylic_acid
thyX 3067790 c.156C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067796 c.150C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067811 c.135G>A synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067823 c.123G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067826 c.120C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073896 c.576C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073980 c.492C>T synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073983 c.489C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074040 c.432G>A synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.29 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.28 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074064 c.408C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074100 p.Asp124Asn missense_variant 0.28 para-aminosalicylic_acid
thyA 3074103 c.369C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074121 p.Asp117Glu missense_variant 0.27 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074147 p.Ile109Val missense_variant 0.23 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087788 c.969G>A synonymous_variant 0.17 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3624032 c.879T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624041 p.Glu290Asp missense_variant 0.33 rifampicin
bedaquiline
lpqB 3624050 c.861C>G synonymous_variant 0.34 rifampicin
bedaquiline
lpqB 3624077 c.834G>C synonymous_variant 0.38 rifampicin
bedaquiline
lpqB 3624080 c.829_831delAGGinsCGC synonymous_variant 0.38 rifampicin
bedaquiline
lpqB 3624101 c.810C>G synonymous_variant 0.35 rifampicin
bedaquiline
lpqB 3624107 c.804C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624113 c.798G>A synonymous_variant 0.32 rifampicin
bedaquiline
lpqB 3624125 c.786A>G synonymous_variant 0.31 rifampicin
bedaquiline
lpqB 3624128 p.Gln261Ala missense_variant 0.29 rifampicin
bedaquiline
lpqB 3624133 c.778A>C synonymous_variant 0.3 rifampicin
bedaquiline
lpqB 3624166 p.Met249Leu missense_variant 0.26 rifampicin
bedaquiline
lpqB 3624172 p.Val247Ile missense_variant 0.2 rifampicin
bedaquiline
lpqB 3624173 c.738A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625072 c.-162G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3625087 p.Ala509Ser missense_variant 0.19 rifampicin
bedaquiline
lpqB 3625090 c.-180C>A upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625117 c.-207T>G upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625123 c.-213T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625134 c.-224T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625135 c.-225A>C upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625141 c.-231T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625147 c.-237C>G upstream_gene_variant 0.28 rifampicin
bedaquiline
lpqB 3625161 c.-251T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625162 c.1452T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625168 c.-258G>T upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625444 p.Glu390Asp missense_variant 0.18 rifampicin
bedaquiline
lpqB 3625489 c.-579A>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3625497 c.1117T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625501 c.-591C>G upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625510 c.-600T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625518 c.-608T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625528 c.-618G>T upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625537 c.-627T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625540 c.-630G>C upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625543 c.-633G>C upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3625569 c.1045T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.28 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3625592 p.Ser341Asn missense_variant 0.27 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.29 rifampicin
bedaquiline
lpqB 3625654 c.-746_-744delTTGinsCTC upstream_gene_variant 0.3 rifampicin
bedaquiline
lpqB 3625663 c.-753G>C upstream_gene_variant 0.32 rifampicin
bedaquiline
lpqB 3625675 c.-765G>C upstream_gene_variant 0.35 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.3 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625747 c.867G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.21 rifampicin Uncertain significance
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625849 c.-939T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 0.97 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626704 c.-91C>T upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3626711 c.-98T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3626723 c.627C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626726 c.-113T>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3626729 c.-116G>A upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3626735 c.-122C>T upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGT upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.4 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3626885 c.-272A>G upstream_gene_variant 0.41 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.42 rifampicin
bedaquiline
mtrB 3626891 c.-278G>C upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.47 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626924 c.-311G>C upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrB 3626933 c.-320C>T upstream_gene_variant 0.43 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrB 3626954 c.-341C>G upstream_gene_variant 0.51 rifampicin
bedaquiline
mtrB 3626969 c.-356C>G upstream_gene_variant 0.47 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.46 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.48 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.45 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrB 3627023 c.-410C>G upstream_gene_variant 0.44 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.34 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627101 c.-488C>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3627125 c.-512C>G upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627139 c.-526T>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627143 c.-530G>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3627146 c.204C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627149 c.-536G>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3627187 c.163T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627188 c.-577_-575delTTAinsCTC upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627191 c.-578G>A upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627196 c.-583C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627197 c.-584T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3627209 c.-596G>A upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.37 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.36 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrA 3627277 c.73C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3627301 c.-688T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3627343 p.Thr3Ser missense_variant 0.29 rifampicin
bedaquiline
mtrB 3627360 c.-747G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627362 c.-749A>T upstream_gene_variant 0.2 rifampicin
bedaquiline
fbiA 3641260 p.Ile240Val missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiA 3641286 c.744C>T synonymous_variant 0.21 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiA 3641288 p.Glu249Gly missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiB 3641295 c.-240G>C upstream_gene_variant 0.2 pretomanid
delamanid
clofazimine
alr 3840987 p.Val145Ala missense_variant 0.22 cycloserine
alr 3840994 p.His143Asp missense_variant 0.23 cycloserine
alr 3840997 c.424T>C synonymous_variant 0.23 cycloserine
alr 3841001 c.420A>G synonymous_variant 0.23 cycloserine
alr 3841005 p.Asp139Ala missense_variant 0.24 cycloserine
alr 3841010 c.411A>G synonymous_variant 0.23 cycloserine
alr 3841017 p.Leu135Glu missense_variant 0.2 cycloserine
alr 3841022 c.399C>G synonymous_variant 0.21 cycloserine
alr 3841028 c.393G>C synonymous_variant 0.2 cycloserine
alr 3841033 p.Val130Ile missense_variant 0.2 cycloserine
alr 3841036 p.Gln129Glu missense_variant 0.2 cycloserine
alr 3841058 c.363G>C synonymous_variant 0.19 cycloserine
alr 3841067 p.Ile118Met missense_variant 0.18 cycloserine
rpoA 3877494 p.Glu338Asp missense_variant 0.21 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.26 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.29 rifampicin
rpoA 3877521 c.987C>G synonymous_variant 0.3 rifampicin
rpoA 3877530 c.978C>T synonymous_variant 0.3 rifampicin
rpoA 3877533 c.975C>G synonymous_variant 0.31 rifampicin
rpoA 3877545 c.963G>C synonymous_variant 0.35 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.33 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.41 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.35 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.32 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.37 rifampicin
rpoA 3877728 c.780C>G synonymous_variant 0.43 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.41 rifampicin
rpoA 3877782 c.726T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877803 c.705G>T synonymous_variant 0.32 rifampicin
rpoA 3877809 c.699G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>G synonymous_variant 0.32 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.34 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.33 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877899 p.Ser203Thr missense_variant 0.23 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.21 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877989 c.519A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877998 c.510G>C synonymous_variant 0.22 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.2 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.2 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.21 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>C synonymous_variant 0.21 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.22 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.23 rifampicin
rpoA 3878073 c.435C>T synonymous_variant 0.23 rifampicin
rpoA 3878079 c.429C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878085 c.423G>A synonymous_variant 0.21 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.31 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.3 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.3 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.22 rifampicin
rpoA 3878142 p.Gly122Glu missense_variant 0.2 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.21 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.24 rifampicin Uncertain significance
rpoA 3878199 c.309T>C synonymous_variant 0.23 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878256 c.252G>C synonymous_variant 0.29 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.31 rifampicin
rpoA 3878284 p.Glu75Ala missense_variant 0.35 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878309 p.Pro67Ala missense_variant 0.35 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.35 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.44 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.43 rifampicin
rpoA 3878379 c.129G>C synonymous_variant 0.38 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.36 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.37 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.35 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.35 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.31 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878989 c.-482G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.24 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.25 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.23 rifampicin
rpoA 3879079 c.-572A>C upstream_gene_variant 0.31 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.31 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.32 rifampicin
rpoA 3879121 c.-615_-614delTTinsAG upstream_gene_variant 0.3 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.27 rifampicin
clpC1 4038530 p.Glu725Asp missense_variant 0.2 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.43 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.49 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.5 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.46 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.46 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.45 pyrazinamide
clpC1 4038698 c.2007C>T synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038701 c.2004G>C synonymous_variant 0.38 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.4 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038770 c.1935C>G synonymous_variant 0.4 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.39 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.43 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.55 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.52 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.5 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.49 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.47 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039031 c.1674T>G synonymous_variant 0.36 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.22 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039316 c.1389G>A synonymous_variant 0.33 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>G synonymous_variant 0.36 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.36 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.37 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.3 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.26 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.26 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039466 c.1239T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.24 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040084 c.621C>G synonymous_variant 0.41 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.41 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040108 c.597G>C synonymous_variant 0.44 pyrazinamide
clpC1 4040129 c.576C>G synonymous_variant 0.42 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.37 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.36 pyrazinamide
clpC1 4040180 c.525C>G synonymous_variant 0.36 pyrazinamide
clpC1 4040189 c.516C>T synonymous_variant 0.34 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040213 c.492T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040228 c.477G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040231 c.474C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040240 c.465C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.33 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040324 c.381G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040335 c.370C>T synonymous_variant 0.22 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.19 pyrazinamide
clpC1 4040372 c.333C>G synonymous_variant 0.18 pyrazinamide
panD 4044629 c.-348G>C upstream_gene_variant 0.21 pyrazinamide
panD 4044650 c.-369G>C upstream_gene_variant 0.26 pyrazinamide
panD 4044653 c.-372C>G upstream_gene_variant 0.28 pyrazinamide
panD 4044662 c.-381C>T upstream_gene_variant 0.33 pyrazinamide
panD 4044677 c.-396T>C upstream_gene_variant 0.33 pyrazinamide
panD 4044682 c.-401C>A upstream_gene_variant 0.33 pyrazinamide
panD 4044686 c.-407_-405delTTCinsCTG upstream_gene_variant 0.32 pyrazinamide
panD 4044692 c.-411G>C upstream_gene_variant 0.33 pyrazinamide
panD 4044700 c.-419C>A upstream_gene_variant 0.37 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.4 pyrazinamide
panD 4044737 c.-456T>G upstream_gene_variant 0.38 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.38 pyrazinamide
panD 4044755 c.-474G>C upstream_gene_variant 0.37 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.3 pyrazinamide
panD 4044785 c.-504C>G upstream_gene_variant 0.31 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.31 pyrazinamide
panD 4044806 c.-525T>C upstream_gene_variant 0.3 pyrazinamide
panD 4044812 c.-531A>G upstream_gene_variant 0.22 pyrazinamide
panD 4044815 c.-534G>A upstream_gene_variant 0.19 pyrazinamide
panD 4044833 c.-552A>C upstream_gene_variant 0.21 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.19 pyrazinamide
panD 4044848 c.-567T>C upstream_gene_variant 0.18 pyrazinamide
glpK 4138418 c.1338T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138421 c.1335G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138427 c.1327_1329delTTGinsCTC synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138451 c.1305T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138606 c.1150T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138610 c.1146C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138634 c.1122G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138640 c.1116C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138643 c.1113A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138670 c.1086G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138679 p.Met359Val missense_variant 0.34 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138696 p.Pro354Ala missense_variant 0.38 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138703 c.1053C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138706 c.1050C>G synonymous_variant 0.36 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138714 p.Ala348Ser missense_variant 0.35 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138724 c.1032A>G synonymous_variant 0.36 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138751 c.1005T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138754 c.1002C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138772 p.Ser328Ala missense_variant 0.33 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138793 c.963T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138796 c.960A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138799 c.957T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138805 c.951C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138817 c.939T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138822 p.Asn312Asp missense_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138829 c.927A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4238986 c.-877_-876delCAinsTG upstream_gene_variant 0.32 ethambutol
embC 4238999 c.-864C>G upstream_gene_variant 0.31 ethambutol Uncertain significance
embC 4239014 c.-849C>G upstream_gene_variant 0.28 ethambutol
embC 4239023 c.-840C>G upstream_gene_variant 0.3 ethambutol
embC 4239027 c.-836A>G upstream_gene_variant 0.29 ethambutol
embC 4239032 c.-831T>C upstream_gene_variant 0.28 ethambutol Uncertain significance
embC 4239042 c.-821A>G upstream_gene_variant 0.28 ethambutol
embC 4239057 c.-806_-804delATGinsGTC upstream_gene_variant 0.27 ethambutol
embC 4239068 c.-795A>G upstream_gene_variant 0.22 ethambutol
embC 4239071 c.-792A>G upstream_gene_variant 0.21 ethambutol Uncertain significance
embC 4239076 c.-787C>T upstream_gene_variant 0.19 ethambutol
embC 4239079 c.-784_-783delCAinsGG upstream_gene_variant 0.2 ethambutol
embC 4239083 c.-780C>G upstream_gene_variant 0.2 ethambutol
embC 4239113 c.-750C>G upstream_gene_variant 0.22 ethambutol
embC 4239125 c.-738C>G upstream_gene_variant 0.19 ethambutol
embC 4239141 c.-722G>A upstream_gene_variant 0.18 ethambutol Uncertain significance
embC 4239161 c.-702A>C upstream_gene_variant 0.18 ethambutol
embC 4240655 p.Ala265Ser missense_variant 0.18 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.18 ethambutol Not assoc w R
embC 4240673 p.Gly271Ser missense_variant 0.18 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.22 ethambutol
embC 4240717 p.His285Gln missense_variant 0.25 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embC 4240729 c.867C>G synonymous_variant 0.32 ethambutol
embC 4240735 c.873C>G synonymous_variant 0.34 ethambutol
embC 4240771 c.909G>C synonymous_variant 0.44 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.43 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.44 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.44 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.41 ethambutol
embC 4240822 c.960C>G synonymous_variant 0.41 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.44 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.36 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.35 ethambutol
embC 4240885 c.1023T>C synonymous_variant 0.32 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.28 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTTG synonymous_variant 0.29 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.23 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.23 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 0.97 ethambutol Not assoc w R
embB 4247992 c.1479G>C synonymous_variant 0.2 ethambutol
embB 4248001 c.1488C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248118 c.1605T>C synonymous_variant 0.2 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
aftB 4267993 p.Thr282Ala missense_variant 0.19 ethambutol
aftB 4267996 p.Met281Leu missense_variant 0.19 ethambutol
aftB 4267999 c.838T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
aftB 4268003 p.Leu278Val missense_variant 0.2 ethambutol
aftB 4268006 c.831A>C synonymous_variant 0.2 ethambutol
aftB 4268018 p.Ser273Leu missense_variant 0.2 ethambutol Uncertain significance
aftB 4268029 p.Leu270Val missense_variant 0.23 ethambutol
aftB 4268041 p.Leu266Val missense_variant 0.22 ethambutol
aftB 4268042 c.795A>G synonymous_variant 0.22 ethambutol
aftB 4268048 c.789G>C synonymous_variant 0.23 ethambutol
aftB 4268052 p.Arg262Ala missense_variant 0.22 ethambutol
aftB 4268056 p.Asn261Asp missense_variant 0.22 ethambutol
aftB 4268066 p.Val257Leu missense_variant 0.23 ethambutol
aftB 4268081 c.756A>G synonymous_variant 0.24 ethambutol
aftB 4268084 c.753G>C synonymous_variant 0.24 ethambutol
ubiA 4269099 c.735G>A synonymous_variant 0.23 ethambutol Not assoc w R - Interim
aftB 4269102 c.-268_-266delAGCinsTCG upstream_gene_variant 0.22 ethambutol
ubiA 4269107 p.Tyr243His missense_variant 0.22 ethambutol
ubiA 4269110 p.Gly242Arg missense_variant 0.22 ethambutol
aftB 4269114 c.-278C>T upstream_gene_variant 0.24 ethambutol
aftB 4269123 c.-287T>G upstream_gene_variant 0.21 ethambutol
ubiA 4269131 c.703C>T synonymous_variant 0.22 ethambutol Not assoc w R - Interim
aftB 4269141 c.-307_-305delTTGinsCTC upstream_gene_variant 0.21 ethambutol
ubiA 4269144 c.690C>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
ubiA 4269164 p.Leu224Met missense_variant 0.2 ethambutol
aftB 4269165 c.-329G>C upstream_gene_variant 0.2 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R