TB-Profiler result

Run: ERR4811035
Summary

Run ID: ERR4811035

Sample name:

Date: 2024-04-15T09:19:44.950037

Number of reads: 2815505

Percentage reads mapped: 37.31

Median coverage: 79.0

Strain: lineage2.2.1;lineage4.5

Spoligotype:

Drug-resistance: Pre-XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.5 Euro-American RD122 0.35
lineage2 East-Asian RD105 0.56
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.58
lineage2.2 East-Asian (Beijing) RD105;RD207 0.6
lineage4 Euro-American None 0.42
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1321_1323delTCGinsGA Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Leu464Met Mutation from literature
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin rpsL p.Lys88Arg Assoc w R
fluoroquinolones
moxifloxacin gyrA p.Asp94Gly Assoc w R High-level resistance
ofloxacin
levofloxacin gyrA p.Asp94Gly Assoc w R
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7582 p.Asp94Gly missense_variant 0.49 levofloxacin Assoc w R
moxifloxacin Assoc w R High-level resistance
rpoB 761127 c.1321_1323delTCGinsGA frameshift_variant&missense_variant 0.26 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.25 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761196 p.Leu464Met missense_variant 0.28 rifampicin Mutation from literature
rpsL 781821 p.Lys88Arg missense_variant 0.26 streptomycin Assoc w R
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.82 amikacin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.66 amikacin Assoc w R
kanamycin Assoc w R
capreomycin Assoc w R
katG 2155168 p.Ser315Thr missense_variant 0.57 isoniazid Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1519 p.Arg507Cys missense_variant 0.56 isoniazid Uncertain significance
gyrB 4935 c.-305C>G upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7892 c.591G>A synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 0.64 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
ccsA 620029 c.139C>T synonymous_variant 0.37 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620625 p.Ile245Met missense_variant 0.49 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 656898 c.573C>A synonymous_variant 0.45 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 0.57 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.65 ethionamide Uncertain significance
rpoB 761102 c.1296A>G synonymous_variant 0.13 rifampicin
rpoB 761126 c.1320G>C synonymous_variant 0.26 rifampicin
rpoB 761147 c.1341C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761186 p.Glu460Asp missense_variant 0.28 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>A synonymous_variant 0.27 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.27 rifampicin
rpoB 761216 c.1410C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761218 p.Pro471His missense_variant 0.27 rifampicin
rpoB 761231 c.1425C>A synonymous_variant 0.28 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761243 c.1437G>C synonymous_variant 0.29 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761933 c.2127G>C synonymous_variant 0.25 rifampicin
rpoB 761951 c.2145G>C synonymous_variant 0.32 rifampicin
rpoB 761955 p.Ile717Phe missense_variant 0.33 rifampicin
rpoB 761972 c.2166C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762002 c.2196C>G synonymous_variant 0.4 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.4 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762015 c.2209_2211delGAAinsCG frameshift_variant&missense_variant 0.39 rifampicin
rpoB 762020 p.Glu738Asp missense_variant 0.38 rifampicin
rpoB 762036 c.2230_2232delATCinsGG frameshift_variant&missense_variant 0.38 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762057 p.Ile751Val missense_variant 0.34 rifampicin Uncertain significance
rpoB 762062 c.2256T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762068 c.2262C>T synonymous_variant 0.32 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762084 c.2278_2280delGCGinsCC frameshift_variant&missense_variant 0.19 rifampicin
rpoB 762098 c.2292C>G synonymous_variant 0.14 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762390 p.Leu862Met missense_variant 0.13 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.13 rifampicin
rpoB 762402 c.2596_2598delTATinsCC frameshift_variant&missense_variant 0.14 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.18 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>C upstream_gene_variant 0.2 rifampicin
rpoC 762452 c.-918G>T upstream_gene_variant 0.19 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762474 p.Gly890Ser missense_variant 0.16 rifampicin
rpoB 762485 c.2679G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762491 c.-879T>G upstream_gene_variant 0.17 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 0.53 rifampicin Not assoc w R
rpoC 763456 c.87A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763462 c.93G>C synonymous_variant 0.33 rifampicin
rpoC 763483 c.114G>C synonymous_variant 0.39 rifampicin
rpoC 763486 c.117T>G synonymous_variant 0.4 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763496 p.Lys43Arg missense_variant 0.39 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.48 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.56 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.57 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.58 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763622 c.253_255delGCCinsTG frameshift_variant&missense_variant 0.72 rifampicin
rpoC 763627 p.Lys86Asn missense_variant 0.72 rifampicin Uncertain significance
rpoC 763639 p.Glu90Asp missense_variant 0.72 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763652 p.Ile95Val missense_variant 0.68 rifampicin
rpoC 763660 c.291T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>T synonymous_variant 0.67 rifampicin
rpoC 763672 c.303C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.6 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.55 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.5 rifampicin
rpoC 763727 c.358_360delCTGinsAC frameshift_variant&missense_variant 0.49 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.49 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.46 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.43 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763772 p.Val135Met missense_variant 0.29 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.25 rifampicin
rpoC 764296 c.927G>C synonymous_variant 0.13 rifampicin
rpoC 764320 c.951C>T synonymous_variant 0.15 rifampicin
rpoC 764323 c.954G>C synonymous_variant 0.15 rifampicin
rpoC 764326 c.957G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764329 c.960C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764332 c.963G>T synonymous_variant 0.16 rifampicin
rpoC 764338 p.Glu323Asp missense_variant 0.23 rifampicin
rpoC 764341 c.972G>T synonymous_variant 0.24 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.26 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764368 c.999C>A synonymous_variant 0.38 rifampicin
rpoC 764371 c.1002G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.4 rifampicin
rpoC 764428 c.1059G>T synonymous_variant 0.42 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCT frameshift_variant&missense_variant 0.38 rifampicin
rpoC 764441 c.1072_1074delATCinsCG frameshift_variant&missense_variant 0.39 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.38 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.38 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764470 c.1101C>G synonymous_variant 0.39 rifampicin
rpoC 764485 c.1116G>C synonymous_variant 0.43 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.37 rifampicin
rpoC 764503 c.1134G>T synonymous_variant 0.36 rifampicin
rpoC 764507 p.Ala380Ser missense_variant 0.36 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>A synonymous_variant 0.46 rifampicin
rpoC 764533 c.1164C>T synonymous_variant 0.48 rifampicin
rpoC 764536 c.1167G>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.54 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsAC frameshift_variant&missense_variant 0.53 rifampicin
rpoC 764578 c.1209C>G synonymous_variant 0.55 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.55 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.55 rifampicin
rpoC 764587 c.1218C>G synonymous_variant 0.57 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.59 rifampicin
rpoC 764605 c.1236G>T synonymous_variant 0.59 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764671 c.1302G>C synonymous_variant 0.64 rifampicin
rpoC 764677 c.1308C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764705 p.Leu446Thr missense_variant 0.62 rifampicin
rpoC 764713 c.1344G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764751 p.Val461Asp missense_variant 0.68 rifampicin
rpoC 764758 c.1389C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764767 c.1398G>C synonymous_variant 0.66 rifampicin
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.63 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.58 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764806 p.Gln479His missense_variant 0.54 rifampicin Uncertain significance
rpoC 764808 p.Arg480His missense_variant 0.53 rifampicin
rpoC 764813 p.Gln482Val missense_variant 0.54 rifampicin
rpoC 764843 p.Ala492Thr missense_variant 0.54 rifampicin
rpoC 764854 c.1485G>C synonymous_variant 0.54 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>A synonymous_variant 0.34 rifampicin
rpoC 764888 c.1519_1521delTTGinsCC frameshift_variant&missense_variant 0.34 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.36 rifampicin
rpoC 764902 c.1533C>G synonymous_variant 0.35 rifampicin
rpoC 764911 c.1542A>C synonymous_variant 0.35 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.35 rifampicin Uncertain significance
rpoC 764918 c.1549_1551delGTGinsAC frameshift_variant&missense_variant 0.34 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.32 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.31 rifampicin
rpoC 764958 p.Glu530Ala missense_variant 0.31 rifampicin
rpoC 764962 c.1593G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764971 c.1602C>T synonymous_variant 0.25 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 0.42 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpS5 779615 c.-710C>G upstream_gene_variant 0.63 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781802 c.243G>C synonymous_variant 0.25 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.25 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.25 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.25 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.26 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.28 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.29 streptomycin
rpsL 781853 c.294C>T synonymous_variant 0.29 streptomycin
rpsL 781856 c.297C>T synonymous_variant 0.29 streptomycin Not assoc w R - Interim
rpsL 781859 c.300T>C synonymous_variant 0.3 streptomycin Not assoc w R - Interim
rpsL 781865 c.306G>C synonymous_variant 0.3 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.3 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.3 streptomycin
rpsL 781884 p.Asn109Gly missense_variant 0.31 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.29 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.29 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.3 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.28 streptomycin
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.53 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303609 p.Gly227Arg missense_variant 0.41 clofazimine
pretomanid
delamanid
Rv1258c 1406760 c.580_581insC frameshift_variant 0.59 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472107 n.262A>G non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472222 n.377G>A non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472225 n.380C>G non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472229 n.384C>T non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>C non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472279 n.434T>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472368 n.523A>G non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472416 n.571C>T non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472430 n.585C>T non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472437 n.592T>G non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472438 n.593T>A non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472439 n.594C>A non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472451 n.606C>G non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472471 n.626G>T non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472472 n.627G>T non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472493 n.648T>G non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472495 n.650C>A non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472507 n.662C>A non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472522 n.677T>G non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472571 n.726G>T non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472582 n.737G>T non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472585 n.740A>C non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472623 n.778A>C non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472673 n.828_842delTTTCCTTCCTTGGGAinsGGACTTCCACGTTC non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472767 n.922G>C non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472791 n.946G>T non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472792 n.947G>C non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472837 n.992C>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472844 n.999C>A non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472845 n.1000G>A non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>A non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472851 n.1006A>G non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472856 n.1011T>C non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472862 n.1017T>C non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472863 n.1018T>C non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472866 n.1021C>T non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472869 n.1024G>T non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472878 n.1033G>A non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>A non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin
rrs 1472958 n.1113A>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472988 n.1143T>A non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>T non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472996 n.1151T>C non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473004 n.1159T>C non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473029 n.1184C>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473063 n.1218C>G non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473065 n.1220C>A non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473081 n.1236C>A non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473130 n.1285G>T non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473226 n.1381C>G non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473262 n.1417T>C non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473292 n.1447_1449delGGAinsTGGG non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473314 n.1469A>G non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473320 n.1475G>A non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473324 n.1479G>A non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474264 n.607T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474265 n.608G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474286 n.631_634delCCTT non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474294 n.638_651delCTCTCCGGAGGAGG non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474355 n.698A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474381 n.724T>A non_coding_transcript_exon_variant 0.12 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474466 n.809G>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474529 n.872A>G non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474540 n.883T>C non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1474583 n.926C>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474613 n.956T>A non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.34 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474800 n.1143T>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474801 n.1144G>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474802 n.1145T>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1474853 n.1196A>G non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475692 n.2035G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475699 n.2042C>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475745 n.2089_2102delGAGGACCCGTTAAC non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475761 n.2104C>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475763 n.2106C>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475767 n.2110G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid Uncertain significance
rrl 1475769 n.2112_2113insCAGCTTACGC non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475776 n.2119G>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475781 n.2124T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475880 n.2223C>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475882 n.2225C>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475892 n.2235A>C non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.15 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476141 n.2484A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476153 n.2496T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.35 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476290 n.2633C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476316 n.2659G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476363 n.2706A>G non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476366 n.2709A>C non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476368 n.2711T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476374 n.2717T>G non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.76 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.72 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476572 n.2915G>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833922 p.Lys127Asn missense_variant 0.2 pyrazinamide Uncertain significance
rpsA 1833928 c.387G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833940 c.399C>T synonymous_variant 0.3 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.37 pyrazinamide
rpsA 1833959 p.Leu140Val missense_variant 0.42 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.47 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.49 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.51 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.53 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.53 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.52 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.52 pyrazinamide
rpsA 1834041 p.Lys167Met missense_variant 0.52 pyrazinamide
rpsA 1834046 p.Ile169Leu missense_variant 0.53 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.52 pyrazinamide
rpsA 1834076 p.Asn179His missense_variant 0.48 pyrazinamide
rpsA 1834090 c.549G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834114 c.573G>T synonymous_variant 0.24 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
rpsA 1834210 c.669C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834237 c.696C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.38 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.37 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834307 p.Asp256Thr missense_variant 0.38 pyrazinamide
rpsA 1834310 p.Glu257Pro missense_variant 0.38 pyrazinamide
rpsA 1834333 p.Asp264Glu missense_variant 0.39 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.39 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834375 c.834G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834395 p.Arg285Gln missense_variant 0.2 pyrazinamide
rpsA 1834397 p.His286Thr missense_variant 0.17 pyrazinamide
rpsA 1834410 p.Thr290Ile missense_variant 0.15 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.14 pyrazinamide
tsnR 1853537 c.-69C>T upstream_gene_variant 0.25 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 0.55 isoniazid Not assoc w R
katG 2155979 c.133C>T synonymous_variant 0.49 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 0.56 pyrazinamide Not assoc w R
PPE35 2168436 c.2176delC frameshift_variant 0.43 pyrazinamide Uncertain significance
PPE35 2170568 p.Ile15Met missense_variant 0.44 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv2752c 3065129 c.1063C>T synonymous_variant 0.53 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ald 3086788 c.-32T>C upstream_gene_variant 0.58 cycloserine
Rv3236c 3612037 p.Phe360Leu missense_variant 0.58 pyrazinamide Uncertain significance
Rv3236c 3612813 p.Thr102Ala missense_variant 0.57 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625941 c.673C>T synonymous_variant 0.58 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626562 p.Pro18Ser missense_variant 0.54 bedaquiline Uncertain significance
rifampicin Not assoc w R
fbiA 3640622 p.Gln27Pro missense_variant 0.61 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
clpC1 4038318 p.Pro796Leu missense_variant 0.42 pyrazinamide Not assoc w R
clpC1 4038798 p.Asn636Thr missense_variant 0.32 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 0.48 ethambutol Not assoc w R
embA 4244170 p.Gln313Arg missense_variant 0.55 ethambutol
embB 4247216 p.Ala235Thr missense_variant 0.37 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.43 ethambutol Not assoc w R
ethA 4326676 p.Ser266Arg missense_variant 0.57 ethionamide Uncertain significance
ethR 4328015 p.Glu156Ala missense_variant 0.55 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407555 c.648A>G synonymous_variant 0.42 streptomycin Not assoc w R - Interim
gid 4407588 c.615A>G synonymous_variant 0.6 streptomycin Not assoc w R
gid 4407760 p.Trp148Leu missense_variant 0.58 streptomycin Uncertain significance
gid 4407927 p.Glu92Asp missense_variant 0.66 streptomycin Not assoc w R