TB-Profiler result

Run: SRR5341267
Summary

Run ID: SRR5341267

Sample name:

Date: 2024-04-15T12:55:09.666449

Number of reads: 931098

Percentage reads mapped: 43.46

Median coverage: 29.0

Strain: lineage3

Spoligotype:

Drug-resistance: Pre-XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Phe Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Ile Assoc w R
pyrazinamide pncA c.-11A>G Assoc w R
streptomycin rrs n.190G>A Mutation from literature
n.799C>T Uncertain significance Mutation from literature
gid c.351delG Assoc w R
fluoroquinolones
moxifloxacin gyrA p.Ala90Val Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ofloxacin
levofloxacin gyrA p.Ala90Val Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7570 p.Ala90Val missense_variant 1.0 moxifloxacin Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
levofloxacin Assoc w R
rpoB 761155 p.Ser450Phe missense_variant 0.58 rifampicin Assoc w R
rrs 1472035 n.190G>A non_coding_transcript_exon_variant 0.79 streptomycin Mutation from literature
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
pncA 2289252 c.-11A>G upstream_gene_variant 1.0 pyrazinamide Assoc w R
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol Assoc w R
gid 4407851 c.351delG frameshift_variant 1.0 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 761132 c.1326G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761159 c.1353G>A synonymous_variant 0.43 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.44 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761178 c.1372_1374delTCAinsAC frameshift_variant&missense_variant 0.44 rifampicin
rpoB 761186 p.Glu460Asp missense_variant 0.44 rifampicin Uncertain significance
rpoB 761192 c.1386C>T synonymous_variant 0.47 rifampicin
rpoB 761195 c.1389G>T synonymous_variant 0.43 rifampicin
rpoB 761198 c.1392G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>A synonymous_variant 0.39 rifampicin
rpoB 761213 c.1407G>T synonymous_variant 0.38 rifampicin
rpoB 761234 c.1428G>T synonymous_variant 0.36 rifampicin
rpoB 761243 c.1437G>A synonymous_variant 0.33 rifampicin
rpoB 761246 c.1440C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761270 c.1464C>T synonymous_variant 0.28 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>A synonymous_variant 0.2 rifampicin
rpoB 761955 p.Ile717Phe missense_variant 0.23 rifampicin
rpoB 761990 c.2184G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762000 p.Ser732Asn missense_variant 0.36 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.36 rifampicin
rpoB 762009 p.Leu735Met missense_variant 0.35 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.35 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762020 c.2214G>A synonymous_variant 0.35 rifampicin
rpoB 762024 c.2218_2220delGTGinsAC frameshift_variant&missense_variant 0.34 rifampicin
rpoB 762029 c.2223C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762059 c.2253C>T synonymous_variant 0.4 rifampicin
rpoB 762062 c.2256T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762084 p.Ala760Pro missense_variant 0.33 rifampicin
rpoB 762095 c.2289C>T synonymous_variant 0.26 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 762785 p.Asp993Glu missense_variant 0.24 rifampicin Uncertain significance
rpoB 762795 p.Asp997Asn missense_variant 0.31 rifampicin Uncertain significance
rpoC 762806 c.-564C>T upstream_gene_variant 0.35 rifampicin
rpoB 762814 p.Met1003Thr missense_variant 0.36 rifampicin Uncertain significance
rpoB 762818 c.3012C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 762831 c.-539_-537delAGCinsTCT upstream_gene_variant 0.37 rifampicin
rpoB 762840 p.Pro1012Lys missense_variant 0.36 rifampicin
rpoB 762850 p.Tyr1015Phe missense_variant 0.35 rifampicin
rpoC 762857 c.-513C>T upstream_gene_variant 0.34 rifampicin
rpoB 762858 p.Thr1018Ser missense_variant 0.34 rifampicin
rpoC 762863 c.-507T>G upstream_gene_variant 0.33 rifampicin
rpoB 762878 p.Ile1024Met missense_variant 0.33 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.34 rifampicin Uncertain significance
rpoB 762899 c.3093G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762905 p.Asp1033Glu missense_variant 0.47 rifampicin
rpoC 762911 c.-459C>T upstream_gene_variant 0.48 rifampicin
rpoC 762917 c.-453C>T upstream_gene_variant 0.48 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 762938 c.-432G>C upstream_gene_variant 0.54 rifampicin
rpoC 762944 c.-426C>T upstream_gene_variant 0.53 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 762971 c.-399G>T upstream_gene_variant 0.58 rifampicin
rpoC 762983 c.-387C>T upstream_gene_variant 0.61 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.61 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763005 p.Cys1067Val missense_variant 0.63 rifampicin
rpoC 763013 c.-357C>A upstream_gene_variant 0.66 rifampicin
rpoC 763022 c.-348C>A upstream_gene_variant 0.64 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.37 rifampicin Not assoc w R
rpoB 763053 c.3247_3249delTTGinsCC frameshift_variant&missense_variant 0.61 rifampicin
rpoB 763074 p.Thr1090Val missense_variant 0.5 rifampicin
rpoC 763079 c.-291C>T upstream_gene_variant 0.5 rifampicin
rpoB 763094 c.3288G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>A upstream_gene_variant 0.39 rifampicin
rpoC 763109 c.-261C>G upstream_gene_variant 0.37 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763118 p.Glu1104Asp missense_variant 0.34 rifampicin
rpoC 763124 c.-246C>T upstream_gene_variant 0.34 rifampicin
rpoB 763130 p.Glu1108Asp missense_variant 0.32 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.31 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.32 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 0.22 rifampicin
rpoC 763163 c.-207C>G upstream_gene_variant 0.21 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>T synonymous_variant 0.22 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763597 c.228G>A synonymous_variant 0.17 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.45 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764374 c.1005C>T synonymous_variant 0.43 rifampicin
rpoC 764377 c.1008C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764398 c.1029G>C synonymous_variant 0.45 rifampicin
rpoC 764404 c.1035C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCT frameshift_variant&missense_variant 0.43 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.42 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCC frameshift_variant&missense_variant 0.43 rifampicin
rpoC 764438 p.Leu357Met missense_variant 0.43 rifampicin
rpoC 764443 c.1074C>T synonymous_variant 0.42 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.41 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.4 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.4 rifampicin
rpoC 764455 c.1086G>T synonymous_variant 0.46 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.42 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.39 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764602 c.1233C>T synonymous_variant 0.35 rifampicin
rpoC 764605 c.1236G>T synonymous_variant 0.31 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764677 c.1308C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764692 c.1323C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>T synonymous_variant 0.35 rifampicin
rpoC 764869 c.1500C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.19 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.17 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764896 c.1527C>T synonymous_variant 0.16 rifampicin
rpoC 764920 c.1551G>T synonymous_variant 0.14 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764926 c.1557C>T synonymous_variant 0.16 rifampicin
rpoC 764932 c.1563C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764952 p.Val528Ala missense_variant 0.21 rifampicin
rpoC 764959 c.1590G>A synonymous_variant 0.2 rifampicin
rpoC 764962 c.1593G>T synonymous_variant 0.19 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766321 c.2952C>A synonymous_variant 0.17 rifampicin
rpoC 766345 c.2976T>A synonymous_variant 0.16 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766351 c.2982C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.16 rifampicin
rpoC 766360 c.2991C>T synonymous_variant 0.17 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.17 rifampicin
rpoC 766369 c.3000C>A synonymous_variant 0.16 rifampicin
rpoC 766378 c.3009C>T synonymous_variant 0.17 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.18 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.18 rifampicin
rpoC 766387 c.3018C>T synonymous_variant 0.18 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.18 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.19 rifampicin
rpoC 766434 p.Glu1022Gly missense_variant 0.19 rifampicin
rpoC 766441 c.3072C>T synonymous_variant 0.19 rifampicin
rpoC 766466 p.Glu1033Lys missense_variant 0.85 rifampicin Uncertain significance
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781793 c.234G>C synonymous_variant 0.22 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.19 streptomycin
rpsL 781805 c.246G>T synonymous_variant 0.2 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.19 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.19 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.19 streptomycin
rpsL 781820 c.261G>T synonymous_variant 0.2 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.21 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.21 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.21 streptomycin
rpsL 781851 p.Ile98Val missense_variant 0.16 streptomycin
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.96 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1304264 p.Gly445Asp missense_variant 1.0 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471858 n.13A>G non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
rrs 1471918 n.73A>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471927 n.82_85delTTCGinsCAGCTTGCT non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471938 n.93T>A non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471972 n.127T>C non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.186_187insTGTG non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472036 n.192_197delATGTCT non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472057 n.212C>T non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472062 n.217G>T non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472150 n.305T>G non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472225 n.380C>G non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472278 n.433C>T non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472279 n.434T>C non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.454_457delTCCG non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472304 n.459G>T non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472307 n.464_471delCTCGGATT non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>A non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472447 n.602C>T non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472451 n.606C>G non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472485 n.640delGinsTA non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472837 n.992C>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472841 n.996G>A non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472843 n.998_999insT non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1003delT non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>T non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472874 n.1029C>T non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472878 n.1033G>A non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.9 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473053 n.1208T>C non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>G non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>T non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473110 n.1265T>C non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473122 n.1277T>G non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473123 n.1278A>C non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473287 n.1442C>A non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473289 n.1444_1445delTCinsATTTTT non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473289 n.1444_1445delTCinsATTTTTT non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473292 n.1447G>T non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473294 n.1449A>G non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474180 n.523T>C non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1474182 n.525C>G non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.529delA non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474289 n.633_647delTTTTCCTCTCCGGAG non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474306 n.649A>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474351 n.694G>C non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474374 n.717_718insTTG non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474384 n.727C>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474447 n.790G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474451 n.794T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474467 n.810A>G non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474487 n.830G>T non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>C non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474517 n.860C>G non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474798 n.1141C>G non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474825 n.1168G>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.89 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474901 n.1244A>G non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474921 n.1264C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474952 n.1296delC non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474958 n.1301A>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475171 n.1514C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475478 n.1821_1822delGCinsTGT non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475481 n.1824C>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475485 n.1828C>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475499 n.1842C>G non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475514 n.1857G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475542 n.1885A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475696 n.2039_2040delTCinsACTT non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475698 n.2041G>T non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1475703 n.2046A>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1475757 n.2101_2104delACCC non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475765 n.2108A>C non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475767 n.2110G>T non_coding_transcript_exon_variant 0.79 capreomycin
linezolid Uncertain significance
rrl 1475769 n.2113_2114insGTCG non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.87 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476029 n.2372A>T non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476091 n.2434_2435insC non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476100 n.2443A>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1476113 n.2456T>G non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.86 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.85 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.85 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.88 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476267 n.2610G>T non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476269 n.2612C>G non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476274 n.2617G>C non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476276 n.2619C>A non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.91 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476523 n.2867delC non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476573 n.2916A>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476600 n.2943A>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.64 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476624 n.2967T>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476666 n.3009C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476675 n.3018C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rpsA 1833847 c.306C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.26 pyrazinamide
rpsA 1833893 p.Ala118Gln missense_variant 0.26 pyrazinamide
rpsA 1833907 p.Lys122Asn missense_variant 0.24 pyrazinamide
rpsA 1833914 c.373_375delGCCinsCG frameshift_variant&missense_variant 0.24 pyrazinamide Uncertain significance
rpsA 1833919 c.378C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1833921 p.Lys127Thr missense_variant 0.24 pyrazinamide
rpsA 1833925 c.384C>T synonymous_variant 0.25 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.37 pyrazinamide
rpsA 1833967 c.426C>T synonymous_variant 0.35 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.35 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.33 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833991 c.450C>T synonymous_variant 0.28 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834000 c.459G>T synonymous_variant 0.28 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.27 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834040 p.Lys167Gln missense_variant 0.3 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834090 c.549G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834093 c.552G>T synonymous_variant 0.2 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834213 c.672G>A synonymous_variant 0.22 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.46 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.46 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834318 c.777C>T synonymous_variant 0.46 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.44 pyrazinamide
rpsA 1834333 p.Asp264Glu missense_variant 0.42 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.39 pyrazinamide Uncertain significance
rpsA 1834343 p.Asp268Asn missense_variant 0.39 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834360 c.819G>T synonymous_variant 0.35 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834366 c.825A>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834375 c.834G>T synonymous_variant 0.39 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834397 p.His286Val missense_variant 0.44 pyrazinamide
rpsA 1834417 c.876G>A synonymous_variant 0.4 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834429 c.888C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834432 c.891G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.26 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834504 c.963G>T synonymous_variant 0.27 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
kanamycin Not assoc w R
rifampicin Not assoc w R
amikacin Not assoc w R
ald 3086739 c.-81G>A upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
clpC1 4039757 c.948A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039769 c.934_936delCTCinsTG frameshift_variant&synonymous_variant 0.23 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039784 c.921C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039799 c.906C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039802 c.903G>A synonymous_variant 0.26 pyrazinamide
clpC1 4039811 c.894C>A synonymous_variant 0.37 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.36 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039831 c.874T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039838 c.865_867delCTGinsAT frameshift_variant&missense_variant 0.4 pyrazinamide
clpC1 4039847 c.858C>T synonymous_variant 0.47 pyrazinamide
clpC1 4039871 p.Thr278Gln missense_variant 0.53 pyrazinamide
clpC1 4039877 c.828C>T synonymous_variant 0.52 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.47 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039925 c.780C>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.32 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.26 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039955 c.750G>T synonymous_variant 0.19 pyrazinamide
clpC1 4039958 c.745_747delACGinsTT frameshift_variant&missense_variant 0.17 pyrazinamide
clpC1 4039964 c.741C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039973 c.732C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.15 pyrazinamide
panD 4044703 c.-422C>G upstream_gene_variant 1.0 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138622 c.1134C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4139183 c.572dupG frameshift_variant 0.93 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4240009 c.147G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4268100 p.Ala246Val missense_variant 1.0 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R