TB-Profiler result

Run: ERR12015083
Summary

Run ID: ERR12015083

Sample name:

Date: 2024-10-05T08:00:00.438409

Number of reads: 1667106

Percentage reads mapped: 89.44

Median coverage: 83.0

Strain: La3;lineage4.8

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.8 Euro-American (mainly T) RD219 0.99
La3 M.orygis None 0.06
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 371 p.Pro124Leu missense_variant 0.99 isoniazid Not assoc w R
dnaA 897 c.897A>G synonymous_variant 0.17 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.18 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.19 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 942 c.942C>G synonymous_variant 0.22 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.21 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.2 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.19 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.19 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.19 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.2 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.22 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>G synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.19 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.19 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.19 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.19 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.19 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.17 isoniazid
dnaA 1041 c.1041G>A synonymous_variant 0.16 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.2 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.16 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.17 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.17 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.17 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.17 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.15 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.15 isoniazid
gyrA 6751 c.-551G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.17 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6868 c.-434G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6877 c.-425G>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6881 c.-421_-419delTTGinsCTC upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6889 c.-413G>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7018 c.-284G>A upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.13 levofloxacin
moxifloxacin
gyrA 7361 c.60C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.16 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7688 c.387C>T synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8207 c.906T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8579 c.1278C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCTA synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8750 c.1449C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Ser missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8807 c.1506C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8816 c.1515C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8837 c.1536C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8948 p.Leu549Phe missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9023 c.1722A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9056 c.1755C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9062 c.1761C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.17 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.15 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.19 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.18 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.18 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.18 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.2 ethionamide
rpoB 760181 c.375T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.21 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.28 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.29 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.28 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.27 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.24 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.25 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.24 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.22 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.22 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.16 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.18 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760949 c.1143C>T synonymous_variant 0.16 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.16 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.19 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.2 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.21 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.2 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.24 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.23 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.23 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.24 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.22 rifampicin
rpoB 761373 p.Val523His missense_variant 0.25 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.23 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.23 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.22 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.22 rifampicin
rpoB 761439 p.Asp545Lys missense_variant 0.22 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.22 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.22 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.22 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.22 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.25 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.24 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.19 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.17 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.17 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.17 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.16 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.17 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.18 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.19 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.2 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.21 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.2 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.21 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.2 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.19 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.22 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.2 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.21 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.16 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.17 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.16 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.2 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.2 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.22 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.21 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.2 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.2 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.22 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.25 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.23 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.22 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.22 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.26 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.27 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.25 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.21 rifampicin
rpoB 762490 p.Val895Asp missense_variant 0.14 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.14 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.33 rifampicin
rpoC 763013 c.-357C>G upstream_gene_variant 0.3 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.25 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.23 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.19 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.17 rifampicin
rpoB 763206 p.Ser1134Trp missense_variant 0.15 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.17 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.15 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.15 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.18 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.19 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.19 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.18 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.18 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.19 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.21 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.18 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.16 rifampicin
rpoC 763936 c.567C>G synonymous_variant 0.15 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.16 rifampicin
rpoC 764101 c.732C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.15 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.16 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.2 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.22 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.21 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.23 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.21 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.22 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.23 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.22 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.15 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.14 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.21 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.19 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.19 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.19 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.21 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.25 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.25 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.22 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.2 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.17 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.15 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.19 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.19 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.17 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.2 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.22 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.22 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.26 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.26 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.26 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.24 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.24 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.24 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.23 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.23 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.25 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.25 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.28 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.26 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.26 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.25 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.24 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.24 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.22 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.23 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.21 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.21 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.18 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.14 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766168 c.2799C>T synonymous_variant 0.16 rifampicin
rpoC 766174 p.Asn935Lys missense_variant 0.16 rifampicin
rpoC 766178 p.Ile937Val missense_variant 0.16 rifampicin
rpoC 766273 c.2904T>C synonymous_variant 0.17 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.17 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.2 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.2 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.22 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.21 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.24 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.25 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.23 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.25 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.25 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.28 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.28 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.31 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.27 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.31 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.27 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.27 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.3 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.24 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.24 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.24 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.2 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.18 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.18 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.17 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.16 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.16 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.18 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.19 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.18 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.15 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.16 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.17 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.16 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.19 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.27 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.32 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.27 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.27 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.27 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.27 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.23 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.15 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781655 c.96T>C synonymous_variant 0.15 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.21 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.22 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.23 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.25 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.26 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.26 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.26 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.26 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.28 streptomycin
rpsL 781763 c.204C>A synonymous_variant 0.27 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.27 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.3 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.32 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.26 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.26 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.26 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.22 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.22 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.22 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.22 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.25 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.25 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.26 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.25 streptomycin Uncertain significance
rplC 800771 c.-38C>T upstream_gene_variant 0.15 linezolid
rplC 800817 c.9A>T synonymous_variant 0.14 linezolid
rplC 800844 c.36T>C synonymous_variant 0.18 linezolid
rplC 800865 c.57A>G synonymous_variant 0.17 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.18 linezolid
rplC 800874 c.66A>G synonymous_variant 0.16 linezolid
rplC 800875 p.Val23Ile missense_variant 0.16 linezolid
rplC 800880 c.72A>G synonymous_variant 0.16 linezolid
rplC 800889 c.81C>G synonymous_variant 0.17 linezolid
rplC 800892 c.84G>C synonymous_variant 0.17 linezolid
rplC 800907 c.99C>G synonymous_variant 0.16 linezolid
rplC 800916 c.108A>G synonymous_variant 0.16 linezolid
rplC 800939 p.Arg44His missense_variant 0.14 linezolid
rplC 801019 p.Thr71Ala missense_variant 0.15 linezolid
rplC 801027 c.219C>G synonymous_variant 0.16 linezolid
rplC 801039 c.231A>G synonymous_variant 0.15 linezolid
rplC 801045 c.237A>G synonymous_variant 0.15 linezolid
rplC 801047 p.Tyr80Phe missense_variant 0.15 linezolid
rplC 801049 c.241C>T synonymous_variant 0.15 linezolid
rplC 801054 c.246G>C synonymous_variant 0.15 linezolid
rplC 801070 p.Asp88Asn missense_variant 0.16 linezolid
rplC 801073 p.Ser89Pro missense_variant 0.16 linezolid
rplC 801078 c.270T>C synonymous_variant 0.16 linezolid
rplC 801081 c.273C>G synonymous_variant 0.16 linezolid Not assoc w R - Interim
rplC 801085 p.Thr93Ala missense_variant 0.16 linezolid Uncertain significance
rplC 801090 c.282G>A synonymous_variant 0.15 linezolid
rplC 801099 c.291T>C synonymous_variant 0.16 linezolid
rplC 801102 c.294G>C synonymous_variant 0.15 linezolid
rplC 801109 c.301T>C synonymous_variant 0.15 linezolid Not assoc w R - Interim
rplC 801114 c.306C>G synonymous_variant 0.16 linezolid
rplC 801117 c.309G>C synonymous_variant 0.15 linezolid
rplC 801127 p.Ala107Thr missense_variant 0.17 linezolid
rplC 801132 c.324T>C synonymous_variant 0.17 linezolid
rplC 801147 c.339T>C synonymous_variant 0.18 linezolid
rplC 801150 c.342G>C synonymous_variant 0.18 linezolid
rplC 801153 c.345G>C synonymous_variant 0.18 linezolid
rplC 801156 c.348T>A synonymous_variant 0.18 linezolid
rplC 801168 c.360C>G synonymous_variant 0.18 linezolid
rplC 801171 c.363A>G synonymous_variant 0.18 linezolid
rplC 801174 c.366T>C synonymous_variant 0.18 linezolid
rplC 801195 c.387G>C synonymous_variant 0.21 linezolid
rplC 801207 c.399C>T synonymous_variant 0.19 linezolid
rplC 801309 c.501C>G synonymous_variant 0.17 linezolid
rplC 801312 c.504G>C synonymous_variant 0.16 linezolid
rplC 801321 c.513C>T synonymous_variant 0.15 linezolid Not assoc w R - Interim
rplC 801348 c.540T>G synonymous_variant 0.16 linezolid
rplC 801357 c.549T>C synonymous_variant 0.16 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.16 linezolid
Rv1129c 1254015 p.Met174Val missense_variant 1.0 levofloxacin
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
fbiC 1303704 c.774T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.15 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303761 c.831T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303905 c.975G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>T synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304658 c.1728C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304661 c.1731C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304670 c.1740G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304671 p.Val581Thr missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304675 p.Gly582Asp missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304691 c.1761G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304694 c.1764A>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304711 p.Ala594Glu missense_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.18 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.19 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304856 c.1926C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304983 c.2053C>T synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304995 p.Leu689Met missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1305006 c.2076A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305012 c.2082G>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1305021 c.2091C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1305033 c.2103T>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1305042 c.2112A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
sigE 1364919 c.507T>C synonymous_variant 0.16 pyrazinamide
sigE 1364943 c.531C>T synonymous_variant 0.14 pyrazinamide
sigE 1364950 p.Ala180Ser missense_variant 0.14 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.15 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.15 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474431 n.774_775delGCinsTTTGGG non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474435 n.780_783delGAAT non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474960 n.1303C>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474963 n.1306G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474965 n.1308G>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.16 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476108 n.2451T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833661 c.120A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.23 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.34 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.28 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834262 p.Ser241Thr missense_variant 0.14 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.23 pyrazinamide
rpsA 1834684 c.1143C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.19 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.19 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.19 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.18 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.19 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064993 c.-265T>C upstream_gene_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518609 p.Met165Ile missense_variant 0.2 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.24 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.23 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.25 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.26 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.28 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.3 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.29 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.29 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.3 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.29 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.29 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.28 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.28 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.27 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.27 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.25 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.26 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.26 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.28 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.25 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.25 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.2 isoniazid
Rv2477c 2782822 c.1221G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782841 p.Thr401Asn missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782847 p.Arg399Lys missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782852 c.1191T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.18 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.23 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.24 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.25 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>A synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783051 p.Tyr331Phe missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783062 c.981C>T synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.19 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.15 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.16 kanamycin
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.13 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3066360 c.-169T>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066370 c.-179G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066380 c.-189A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066465 c.-276_-274delGGGinsAGT upstream_gene_variant 0.14 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066482 c.-291G>T upstream_gene_variant 0.14 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066483 c.-292T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066501 c.-310G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066561 c.-370A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066583 c.-392C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066603 c.-412A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066617 c.-426G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066618 c.-427A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066633 c.-442T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066638 c.-447T>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066642 c.-451G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066654 c.-463G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067355 c.591A>C synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.31 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.44 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.41 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.4 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.38 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.38 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.38 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.38 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.36 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.38 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067691 p.Ile85Leu missense_variant 0.32 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067736 p.Phe70Leu missense_variant 0.19 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067762 c.184C>A synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.14 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.19 para-aminosalicylic_acid
mtrA 3626801 p.Trp183Cys missense_variant 0.19 rifampicin
bedaquiline
mtrA 3627007 p.Arg115Trp missense_variant 0.22 rifampicin
bedaquiline
mtrB 3627065 c.-452G>T upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627071 c.279G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3627221 c.129C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
alr 3840764 c.657G>C synonymous_variant 1.0 cycloserine
clpC1 4038749 c.1956C>A synonymous_variant 0.15 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.21 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.25 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.25 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.21 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.21 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.17 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039991 c.714G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040033 c.672G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.16 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.14 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.15 pyrazinamide
panD 4044017 p.Ala89Thr missense_variant 0.96 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.15 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.16 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.17 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.17 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.18 pyrazinamide
panD 4044833 c.-552A>G upstream_gene_variant 0.2 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.19 pyrazinamide
panD 4044848 c.-567T>A upstream_gene_variant 0.21 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.22 pyrazinamide
panD 4044860 c.-579C>G upstream_gene_variant 0.23 pyrazinamide
panD 4044872 c.-591C>G upstream_gene_variant 0.28 pyrazinamide
panD 4044890 c.-609G>C upstream_gene_variant 0.26 pyrazinamide
panD 4044895 c.-614A>G upstream_gene_variant 0.26 pyrazinamide
panD 4044896 c.-615T>G upstream_gene_variant 0.26 pyrazinamide
panD 4044902 c.-623_-621delACGinsGCC upstream_gene_variant 0.26 pyrazinamide
panD 4044908 c.-628_-627delCTinsTC upstream_gene_variant 0.27 pyrazinamide
panD 4044917 c.-636G>C upstream_gene_variant 0.29 pyrazinamide
panD 4044926 c.-645C>A upstream_gene_variant 0.28 pyrazinamide
panD 4044929 c.-648G>C upstream_gene_variant 0.28 pyrazinamide
panD 4044935 c.-655_-654delAAinsTG upstream_gene_variant 0.28 pyrazinamide
panD 4044941 c.-660G>C upstream_gene_variant 0.29 pyrazinamide
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 0.29 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.3 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.31 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.31 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.28 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.29 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.25 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.24 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.23 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.22 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.19 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.18 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.17 pyrazinamide
embC 4240780 c.918T>C synonymous_variant 0.16 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.17 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.18 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.15 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.15 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.16 ethambutol
embC 4241218 c.1356G>C synonymous_variant 0.15 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.16 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.16 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.16 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.16 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.16 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.17 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.18 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.18 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.19 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.2 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.21 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.2 ethambutol
embC 4241635 c.1773G>C synonymous_variant 0.19 ethambutol
embC 4241644 c.1782G>C synonymous_variant 0.18 ethambutol
embC 4241648 c.1786_1788delTTGinsCTC synonymous_variant 0.16 ethambutol
embC 4241657 p.Ser599Pro missense_variant 0.16 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.97 ethambutol Not assoc w R
embA 4245578 c.2346G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
ethA 4328338 c.-865G>A upstream_gene_variant 1.0 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R