TB-Profiler result

Run: SRR23961549
Summary

Run ID: SRR23961549

Sample name:

Date: 2024-03-27T02:43:33.065957

Number of reads: 6745489

Percentage reads mapped: 91.85

Median coverage: 122.0

Strain: La1.2

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.2 M.bovis None 1.0
La1 M.bovis None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide pncA p.His57Asp Assoc w R
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.21 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance Mutation from literature
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 467 p.His156Arg missense_variant 1.0 isoniazid Not assoc w R
dnaA 741 c.741T>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>T synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 756 c.756T>C synonymous_variant 0.21 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.21 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.21 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.21 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.21 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.23 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.23 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.23 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.24 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.24 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.22 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.22 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 877 c.877T>C synonymous_variant 0.16 isoniazid
dnaA 909 c.909A>G synonymous_variant 0.17 isoniazid
dnaA 912 c.912T>G synonymous_variant 0.17 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.18 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 927 c.927G>A synonymous_variant 0.19 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.22 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.25 isoniazid
dnaA 954 c.954G>C synonymous_variant 0.25 isoniazid
dnaA 957 c.957A>G synonymous_variant 0.24 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.23 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.23 isoniazid
dnaA 975 c.975G>C synonymous_variant 0.22 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 987 c.987C>T synonymous_variant 0.22 isoniazid
dnaA 990 c.990A>G synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.22 isoniazid
dnaA 996 c.996A>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 999 c.999C>G synonymous_variant 0.22 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 1023 c.1023C>T synonymous_variant 0.21 isoniazid
dnaA 1029 c.1029C>T synonymous_variant 0.19 isoniazid
dnaA 1038 c.1038A>G synonymous_variant 0.16 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 1104 c.1104T>C synonymous_variant 0.3 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.3 isoniazid
dnaA 1131 c.1131C>T synonymous_variant 0.31 isoniazid
dnaA 1134 c.1134G>C synonymous_variant 0.3 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.31 isoniazid
dnaA 1152 c.1152A>C synonymous_variant 0.32 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.32 isoniazid
dnaA 1164 c.1164A>G synonymous_variant 0.35 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.37 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.38 isoniazid
dnaA 1179 c.1179G>C synonymous_variant 0.37 isoniazid
dnaA 1188 c.1188G>A synonymous_variant 0.38 isoniazid
dnaA 1195 c.1195_1197delCTTinsTG frameshift_variant&missense_variant 0.37 isoniazid Uncertain significance
dnaA 1215 c.1215C>T synonymous_variant 0.39 isoniazid
dnaA 1218 c.1218C>G synonymous_variant 0.39 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.39 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.37 isoniazid
dnaA 1242 c.1242G>A synonymous_variant 0.32 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.32 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>G synonymous_variant 0.31 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.3 isoniazid
dnaA 1281 c.1281C>G synonymous_variant 0.3 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.29 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.27 isoniazid
dnaA 1299 c.1299G>A synonymous_variant 0.26 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.21 isoniazid
gyrB 5752 c.513G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6406 c.1167C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6446 p.Ala403Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6775 c.1536G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.16 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7763 c.462T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8090 c.789C>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8126 c.825G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8129 c.828T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8177 c.876A>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8210 c.909G>A synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8222 c.921C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8228 c.927G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8240 c.939C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8246 c.945C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.29 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8375 c.1074G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8456 c.1155C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8472 c.1171C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8492 c.1191G>T synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 8528 c.1227G>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8540 c.1239C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8543 c.1242C>G synonymous_variant 0.46 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 p.Asp415Glu missense_variant 0.46 levofloxacin
moxifloxacin
gyrA 8552 c.1251C>A synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.48 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8576 c.1275C>G synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8627 c.1326C>G synonymous_variant 0.53 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8655 p.Ile452Val missense_variant 0.53 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8681 c.1380C>G synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 8690 c.1389C>G synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.37 levofloxacin Uncertain significance
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.35 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8762 c.1461G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8780 p.Asp493Glu missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8783 c.1482G>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8818 p.Ser506Asn missense_variant 0.28 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8888 c.1587C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13197 p.Thr121Ser missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13228 c.330delG frameshift_variant 1.0 isoniazid Uncertain significance
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
hadA 731690 c.-240_-237delAGACinsCAGCTTTTTTGAAGAA upstream_gene_variant 0.28 isoniazid
hadA 731694 c.-235_-234delCG upstream_gene_variant 0.29 isoniazid
hadA 731698 c.-232T>G upstream_gene_variant 0.29 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.29 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.28 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.29 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.35 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.34 isoniazid
hadA 731748 c.-182T>C upstream_gene_variant 0.34 isoniazid
hadA 731768 c.-162G>A upstream_gene_variant 0.26 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.18 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.18 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.16 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.15 isoniazid
nusG 734421 c.168A>G synonymous_variant 0.16 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.17 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.2 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.2 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.22 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>C synonymous_variant 0.24 rifampicin
nusG 734481 c.228C>G synonymous_variant 0.25 rifampicin
nusG 734502 c.249G>A synonymous_variant 0.26 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.19 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.14 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.16 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.18 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.19 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.19 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760805 c.999G>C synonymous_variant 0.17 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.2 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.21 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.25 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.27 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.28 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.34 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.46 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.44 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.44 rifampicin
rpoB 760937 c.1131G>A synonymous_variant 0.46 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.43 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.42 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761129 c.1323G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.17 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.17 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.24 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.27 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.33 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.26 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761669 c.1863C>T synonymous_variant 0.22 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.18 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.24 rifampicin
rpoB 761717 c.1911C>G synonymous_variant 0.23 rifampicin
rpoB 761723 c.1917_1919delAGAinsC frameshift_variant&missense_variant 0.22 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.21 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.24 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.24 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.27 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.27 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.25 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.25 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.26 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.26 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.25 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.23 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.22 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.23 rifampicin
rpoB 761867 c.2061C>G synonymous_variant 0.23 rifampicin
rpoB 761870 p.Asp688Glu missense_variant 0.23 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.23 rifampicin
rpoB 761876 c.2070C>T synonymous_variant 0.24 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.24 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.23 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.2 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.21 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.21 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.21 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.21 rifampicin
rpoB 761942 c.2136C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761948 c.2142G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.16 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.16 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.15 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.24 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.24 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.19 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.21 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.21 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.22 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763636 c.267T>C synonymous_variant 0.15 rifampicin
rpoC 763648 c.279C>T synonymous_variant 0.15 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.17 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.18 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.17 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.18 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.18 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.21 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.22 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764140 c.771C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.23 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.23 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.22 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.15 rifampicin
rpoC 764383 c.1014C>G synonymous_variant 0.16 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.17 rifampicin
rpoC 764419 c.1050C>G synonymous_variant 0.17 rifampicin
rpoC 764742 p.Lys458Arg missense_variant 0.86 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.19 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.3 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764848 c.1479G>A synonymous_variant 0.28 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.23 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.23 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.28 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.28 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.27 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.27 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.24 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.25 rifampicin
rpoC 766288 c.2919C>T synonymous_variant 0.16 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.23 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.3 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.34 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.35 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.35 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.35 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.34 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.35 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.29 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.27 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.37 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.37 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.36 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.4 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.47 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.5 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.57 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.54 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 766816 c.3447C>T synonymous_variant 0.55 rifampicin
rpoC 766861 c.3492G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.56 rifampicin
rpoC 766882 c.3513C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766885 c.3516G>T synonymous_variant 0.52 rifampicin
rpoC 766888 c.3519G>C synonymous_variant 0.52 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.51 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.52 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.51 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766921 c.3552G>C synonymous_variant 0.51 rifampicin
rpoC 766924 p.Glu1185Asp missense_variant 0.52 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.51 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 766951 c.3582G>T synonymous_variant 0.52 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.46 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.43 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767102 c.3733_3735delCTCinsTG frameshift_variant&missense_variant 0.36 rifampicin
rpoC 767105 c.3736_3738delAACinsCG frameshift_variant&missense_variant 0.36 rifampicin
rpoC 767119 c.3750A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.24 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775817 c.2664T>C synonymous_variant 0.17 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775834 p.Ala883Ser missense_variant 0.15 clofazimine
bedaquiline
mmpL5 775847 c.2634G>T synonymous_variant 0.17 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mmpL5 775851 p.Ser877Thr missense_variant 0.22 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 775864 p.Ala873Ser missense_variant 0.16 clofazimine
bedaquiline
mmpL5 775865 c.2616T>A synonymous_variant 0.24 clofazimine
bedaquiline
mmpL5 775883 c.2596_2598delATCinsCG frameshift_variant&missense_variant 0.19 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 775886 c.2595A>C synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.18 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.15 streptomycin
rplC 800516 c.-293G>T upstream_gene_variant 0.2 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.19 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.18 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.17 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.17 linezolid
rplC 800594 c.-215C>T upstream_gene_variant 0.18 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.17 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.17 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1129c 1254582 c.-48A>G upstream_gene_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1303686 c.756C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303740 c.810C>T synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303746 c.816T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303788 c.858T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303794 c.864A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
sigE 1364961 c.549A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.41 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473752 n.95G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474431 n.774_775delGCinsTTTGGG non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474435 n.780_783delGAAT non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475007 n.1350C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475008 n.1351C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
fabG1 1673750 p.Lys104Arg missense_variant 0.19 ethionamide
isoniazid
inhA 1673769 c.-433C>T upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673784 c.-418G>C upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1673796 c.-406G>C upstream_gene_variant 0.15 ethionamide
isoniazid
inhA 1673799 c.-403T>C upstream_gene_variant 0.16 ethionamide
isoniazid
inhA 1673802 c.-400A>G upstream_gene_variant 0.16 ethionamide
isoniazid
inhA 1673805 c.-397G>C upstream_gene_variant 0.16 ethionamide
isoniazid
inhA 1673808 c.-394A>G upstream_gene_variant 0.16 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674699 c.498C>T synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674718 c.517_519delAGGinsCA frameshift_variant&missense_variant 0.2 ethionamide
isoniazid
inhA 1674732 c.531C>T synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674746 p.Tyr182Phe missense_variant 0.25 ethionamide
isoniazid
inhA 1674756 c.555T>C synonymous_variant 0.26 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674774 c.573A>G synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674795 c.594G>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674804 c.603G>C synonymous_variant 0.29 ethionamide Not assoc w R - Interim
isoniazid
inhA 1674822 c.621C>G synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674828 c.627G>A synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674831 c.630G>A synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674840 c.639C>G synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.25 ethionamide
isoniazid
inhA 1674852 c.651G>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674858 c.657G>A synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674870 c.669T>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674882 c.681G>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674960 c.759C>G synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674966 c.765T>G synonymous_variant 0.15 ethionamide
isoniazid
rpsA 1833595 c.54T>G synonymous_variant 0.16 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1833772 c.231C>T synonymous_variant 0.16 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.39 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.43 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.45 pyrazinamide
rpsA 1833991 c.450C>T synonymous_variant 0.48 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.48 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.48 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.36 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.29 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.3 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.39 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834294 c.753G>T synonymous_variant 0.42 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.41 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.31 pyrazinamide
rpsA 1834390 c.849G>A synonymous_variant 0.28 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834429 c.888C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834859 p.Ala440Thr missense_variant 1.0 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
ndh 2102106 p.Gly313Arg missense_variant 1.0 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Not assoc w R - Interim
ndh 2102407 c.636T>C synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2102413 c.630G>T synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102422 c.621C>G synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102443 c.598_600delGCAinsTG frameshift_variant&missense_variant 0.2 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2102450 p.Lys198Arg missense_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102460 p.His195Asp missense_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2102463 p.Glu194Lys missense_variant 0.21 ethionamide Uncertain significance
delamanid
isoniazid Uncertain significance
ndh 2102464 c.579C>G synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102469 c.574C>T synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102470 c.573G>A synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102473 c.570C>G synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2102482 c.561A>G synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2102494 c.549T>C synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102497 c.546T>C synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2102509 c.534T>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102517 p.Val176Ile missense_variant 0.21 ethionamide Uncertain significance
delamanid
isoniazid Uncertain significance
ndh 2102518 c.525T>G synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102521 c.522C>T synonymous_variant 0.2 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102527 c.516A>G synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2102533 c.510A>G synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2102545 c.498G>A synonymous_variant 0.17 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2103173 c.-132delG upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
katG 2156025 c.87C>A synonymous_variant 1.0 isoniazid Not assoc w R
katG 2156465 c.-354C>T upstream_gene_variant 1.0 isoniazid Not assoc w R - Interim
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168011 p.Ser868Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168814 c.1798dupA frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.16 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.16 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.15 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.18 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.18 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.16 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.16 isoniazid
kasA 2518618 c.504G>C synonymous_variant 0.16 isoniazid
Rv2477c 2782913 p.Ser377Thr missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Gln missense_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>T synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783014 p.Ser343Thr missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783038 c.1003_1005delGCCinsAT frameshift_variant&missense_variant 0.38 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783110 c.933C>T synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.35 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.34 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783191 c.850_852delAGCinsGA frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783194 c.849A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783812 c.231G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783962 c.81T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2681 2997325 p.Ala196Val missense_variant 1.0 capreomycin Uncertain significance
Rv2752c 3065955 c.235_237delTTGinsCC frameshift_variant&missense_variant 0.15 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065979 c.213T>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065988 c.204A>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066002 p.Met64Leu missense_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066003 c.189C>T synonymous_variant 0.19 ethambutol
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin
isoniazid
Rv2752c 3066024 c.168T>C synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyA 3073800 c.672G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073803 p.Glu223Asp missense_variant 0.28 para-aminosalicylic_acid
thyA 3073812 c.660C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3073824 c.648A>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3073827 c.645A>G synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.42 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.46 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.44 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.4 para-aminosalicylic_acid
thyA 3073889 p.Ser195Ala missense_variant 0.38 para-aminosalicylic_acid
thyA 3073890 c.580_582delTTGinsCC frameshift_variant&missense_variant 0.38 para-aminosalicylic_acid
thyA 3073917 c.555C>A synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.44 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3073980 c.492C>T synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.45 para-aminosalicylic_acid
thyA 3074000 c.472C>A synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.39 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.4 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.31 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.3 para-aminosalicylic_acid
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
fbiD 3339154 p.Ile13Leu missense_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
Rv3083 3448745 p.Ile81Ser missense_variant 1.0 ethionamide Uncertain significance
Rv3083 3448783 p.Val94Ile missense_variant 1.0 ethionamide Uncertain significance
lpqB 3623730 p.Ser394Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624350 c.561G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624593 c.318G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624710 c.201G>A synonymous_variant 0.99 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625750 c.864G>A synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.23 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625786 c.-876C>T upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625797 p.Val273Met missense_variant 0.19 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625798 c.-888G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625852 c.762A>G synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
rpoA 3877515 c.993G>C synonymous_variant 0.24 rifampicin
rpoA 3877524 c.984C>A synonymous_variant 0.31 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.34 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.55 rifampicin
rpoA 3877653 c.855C>T synonymous_variant 0.54 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.54 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.51 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877752 c.756C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.29 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877821 c.687C>G synonymous_variant 0.21 rifampicin
rpoA 3877839 c.669G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878630 c.-124delC upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoA 3879121 c.-614T>G upstream_gene_variant 0.2 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.21 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.22 rifampicin
rpoA 3879163 c.-656C>T upstream_gene_variant 1.0 rifampicin
rpoA 3879190 c.-683C>T upstream_gene_variant 0.21 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.19 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879238 c.-731C>T upstream_gene_variant 0.17 rifampicin
clpC1 4038403 c.2302T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038623 c.2082A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.26 pyrazinamide
clpC1 4038644 p.Glu687Asp missense_variant 0.27 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.28 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.28 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038671 c.2034T>A synonymous_variant 0.3 pyrazinamide
clpC1 4038674 c.2031C>G synonymous_variant 0.3 pyrazinamide
clpC1 4038683 c.2022T>G synonymous_variant 0.31 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.31 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038773 c.1932T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.35 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038838 c.1867C>T synonymous_variant 0.44 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.45 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.5 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.51 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.44 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.4 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039025 c.1680C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039040 c.1665C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039049 c.1656C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039094 c.1611C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039258 p.Gln483Glu missense_variant 0.21 pyrazinamide
clpC1 4039259 c.1444_1446delGAGinsAC frameshift_variant&missense_variant 0.21 pyrazinamide
clpC1 4039268 c.1437C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039328 p.Ala459Gly missense_variant 0.35 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.34 pyrazinamide
clpC1 4039346 c.1359G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.47 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.46 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.45 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.39 pyrazinamide
clpC1 4039454 c.1251A>T synonymous_variant 0.36 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.35 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.15 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040393 c.312G>T synonymous_variant 0.2 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040438 c.267G>A synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040444 c.261C>G synonymous_variant 0.29 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040462 c.243C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040477 c.228G>A synonymous_variant 0.25 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040486 c.219G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040510 c.195G>A synonymous_variant 0.29 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>T synonymous_variant 0.27 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>T synonymous_variant 0.26 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.2 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4240615 c.753G>C synonymous_variant 0.27 ethambutol
embC 4240630 c.768C>A synonymous_variant 0.31 ethambutol
embC 4240633 p.Met257Ile missense_variant 0.33 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.36 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.38 ethambutol
embC 4240657 c.795G>T synonymous_variant 0.46 ethambutol
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240676 p.Gly272Pro missense_variant 0.44 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.47 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.47 ethambutol
embC 4240695 p.Ile278Thr missense_variant 0.44 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.43 ethambutol Not assoc w R - Interim
embC 4240701 p.Val280Ala missense_variant 0.43 ethambutol Uncertain significance
embC 4240726 c.864G>C synonymous_variant 0.5 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.39 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.38 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.39 ethambutol
embC 4240813 p.Phe317Leu missense_variant 0.38 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.39 ethambutol
embC 4240828 c.966G>T synonymous_variant 0.41 ethambutol Not assoc w R - Interim
embC 4240831 c.969T>G synonymous_variant 0.42 ethambutol
embC 4240855 c.993G>C synonymous_variant 0.43 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.41 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.38 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.36 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.37 ethambutol
embC 4240886 p.Ile342Val missense_variant 0.37 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.38 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.43 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.46 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.46 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.47 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.52 ethambutol
embC 4240945 c.1083T>C synonymous_variant 0.46 ethambutol
embC 4240948 c.1086G>A synonymous_variant 0.45 ethambutol Not assoc w R - Interim
embC 4240954 p.Ile364Met missense_variant 0.48 ethambutol
embC 4240960 c.1098G>C synonymous_variant 0.47 ethambutol
embC 4240966 c.1104G>C synonymous_variant 0.45 ethambutol
embC 4240979 p.Thr373Gln missense_variant 0.41 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.4 ethambutol
embC 4240988 c.1126_1128delGCAinsAC frameshift_variant&missense_variant 0.4 ethambutol
embC 4240996 c.1134G>C synonymous_variant 0.4 ethambutol
embC 4241002 c.1140G>C synonymous_variant 0.41 ethambutol
embC 4241013 p.Met384Thr missense_variant 0.41 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.43 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.43 ethambutol
embC 4241044 c.1182C>T synonymous_variant 0.47 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.46 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.4 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.37 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.36 ethambutol
embC 4241122 c.1260C>T synonymous_variant 0.36 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embC 4241150 p.Ile430Val missense_variant 0.32 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.27 ethambutol
embC 4241167 c.1305C>G synonymous_variant 0.27 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.27 ethambutol
embC 4241179 c.1317G>A synonymous_variant 0.25 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.27 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.26 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.26 ethambutol
embC 4241483 c.1621_1623delGTGinsAC frameshift_variant&missense_variant 0.26 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.27 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.28 ethambutol
embC 4241498 c.1636_1638delGTAinsAC frameshift_variant&missense_variant 0.28 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.27 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.3 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>G synonymous_variant 0.31 ethambutol
embC 4241536 c.1674A>C synonymous_variant 0.31 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.32 ethambutol
embC 4241547 p.Ala562Val missense_variant 0.32 ethambutol
embC 4241551 c.1689A>C synonymous_variant 0.32 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.3 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.27 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.24 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.2 ethambutol
embC 4241648 c.1786T>C synonymous_variant 0.14 ethambutol Not assoc w R - Interim
embC 4241657 p.Ser599Pro missense_variant 0.15 ethambutol
embC 4241665 c.1803G>C synonymous_variant 0.32 ethambutol
embC 4241671 c.1809T>G synonymous_variant 0.31 ethambutol
embC 4241689 c.1827G>C synonymous_variant 0.31 ethambutol
embC 4241690 p.Gly610Ser missense_variant 0.31 ethambutol Uncertain significance
embC 4241694 p.Ala611Val missense_variant 0.31 ethambutol
embC 4241704 c.1842C>A synonymous_variant 0.31 ethambutol
embC 4241707 c.1845G>C synonymous_variant 0.31 ethambutol
embC 4241713 c.1851G>C synonymous_variant 0.31 ethambutol
embC 4241719 c.1857G>C synonymous_variant 0.32 ethambutol
embC 4241727 p.Phe622Tyr missense_variant 0.31 ethambutol
embC 4241731 c.1869C>G synonymous_variant 0.3 ethambutol
embC 4241741 c.1879_1881delGTCinsCG frameshift_variant&missense_variant 0.3 ethambutol
embC 4241747 p.Val629Leu missense_variant 0.3 ethambutol
embC 4241750 c.1888_1890delTTGinsGC frameshift_variant&missense_variant 0.31 ethambutol
embC 4241755 c.1893C>G synonymous_variant 0.3 ethambutol
embC 4241756 c.1894C>T synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embC 4241770 c.1908T>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embC 4241791 c.1929G>C synonymous_variant 0.29 ethambutol
embC 4241794 c.1932C>G synonymous_variant 0.26 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242970 c.3108C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247028 p.Leu172Arg missense_variant 0.3 ethambutol
embB 4247173 c.660G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
aftB 4267858 p.Ile327Val missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R