TB-Profiler result

Run: SRR6079962
Summary

Run ID: SRR6079962

Sample name:

Date: 2024-10-04T17:01:56.402709

Number of reads: 3114376

Percentage reads mapped: 82.13

Median coverage: 90.0

Strain: lineage2.2.1.1

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.97
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.97
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
lineage2.2.1.1 East-Asian (Beijing) RD105;RD207;RD181;RD150 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethambutol
pyrazinamide
streptomycin rpsL p.Lys43Arg Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
clofazimine pepQ c.641_642delTC Assoc w R - Interim
c.636_637insGC Assoc w R - Interim
para-aminosalicylic_acid
delamanid
bedaquiline pepQ c.641_642delTC Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
c.636_637insGC Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpsL 781687 p.Lys43Arg missense_variant 0.87 streptomycin Assoc w R
inhA 1673425 c.-777C>T upstream_gene_variant 1.0 ethionamide Assoc w R Alias fabG1_c.-15C>T
isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
pepQ 2859776 c.641_642delTC frameshift_variant 0.2 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
pepQ 2859782 c.636_637insGC frameshift_variant 0.17 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6649 c.-653T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6658 c.-644G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6724 c.-578G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6787 c.-515G>A upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.23 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.23 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6869 c.-433T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6877 c.-425G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6881 c.1642T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6976 c.-326A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7027 c.-275G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7051 c.1812A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7120 c.-182T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7168 c.-134C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7201 c.-101G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8453 c.1152A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8492 c.1191G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8501 c.1200G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8537 c.1236G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8570 c.1269G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8609 c.1308G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8813 p.Asp504Glu missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9200 c.1899A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575907 p.Ala187Val missense_variant 0.91 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 619531 c.-360T>C upstream_gene_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 619535 c.-356C>G upstream_gene_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 619543 c.-348C>G upstream_gene_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620265 c.375C>G synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620269 p.Val127Phe missense_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620280 c.390C>A synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620283 c.393T>C synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620284 p.Ala132Pro missense_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620288 p.Arg133Gln missense_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620295 c.405G>C synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620307 c.417C>T synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620319 c.429C>G synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620322 c.432G>C synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620325 c.435G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620329 p.Ile147Val missense_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620349 c.459A>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>A synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>T synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
ccsA 620682 c.792G>A synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620688 c.798G>T synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620694 c.804C>G synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620697 c.807C>T synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620703 c.813G>A synonymous_variant 0.15 kanamycin
capreomycin
amikacin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.16 ethionamide
nusG 734820 c.567A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>G synonymous_variant 0.22 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734847 c.594T>C synonymous_variant 0.19 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.19 rifampicin
nusG 734859 c.606G>C synonymous_variant 0.18 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.2 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760271 c.465C>G synonymous_variant 0.18 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.17 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.16 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.2 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.19 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.19 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.19 rifampicin
rpoB 760784 c.978G>C synonymous_variant 0.21 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.22 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.25 rifampicin
rpoB 760808 c.1002C>G synonymous_variant 0.27 rifampicin
rpoB 760814 c.1008C>T synonymous_variant 0.26 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.26 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.26 rifampicin
rpoB 760856 c.1050C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760862 c.1056G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760865 c.1059C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.24 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.24 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.2 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761030 c.1224G>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>G synonymous_variant 0.25 rifampicin
rpoB 761192 c.1386C>G synonymous_variant 0.25 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761286 c.1480C>T synonymous_variant 0.34 rifampicin
rpoB 761300 c.1494G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.29 rifampicin
rpoB 761346 p.Val514Ile missense_variant 0.28 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.34 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761374 p.Val523Glu missense_variant 0.31 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.32 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.3 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.28 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.27 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.27 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.25 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.26 rifampicin
rpoB 761462 c.1656C>G synonymous_variant 0.26 rifampicin
rpoB 761465 c.1659G>C synonymous_variant 0.27 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.27 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.29 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.27 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.26 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.28 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>C synonymous_variant 0.25 rifampicin
rpoB 761603 c.1797C>G synonymous_variant 0.24 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.23 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>C synonymous_variant 0.23 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761657 c.1851C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>A synonymous_variant 0.22 rifampicin
rpoB 761687 c.1881C>T synonymous_variant 0.19 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.21 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.24 rifampicin
rpoB 761720 c.1914_1916delCGAinsGG frameshift_variant&synonymous_variant 0.22 rifampicin
rpoB 761727 p.Ser641Val missense_variant 0.24 rifampicin
rpoB 761729 c.1925dupG frameshift_variant 0.23 rifampicin
rpoB 761735 c.1929C>G synonymous_variant 0.23 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.24 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.23 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.3 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.28 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.27 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.22 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.21 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.21 rifampicin
rpoB 761819 c.2013G>C synonymous_variant 0.2 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.19 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.17 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.18 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761867 c.2061C>G synonymous_variant 0.19 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.17 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.2 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.2 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.18 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.16 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.17 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.17 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.18 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.2 rifampicin
rpoB 761951 c.2145G>C synonymous_variant 0.19 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761955 p.Ile717Val missense_variant 0.19 rifampicin Uncertain significance
rpoB 761972 c.2166C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762011 c.2205G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762029 c.2223C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762032 c.2226C>G synonymous_variant 0.19 rifampicin
rpoB 762041 c.2235C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.16 rifampicin Uncertain significance
rpoB 762143 c.2337T>C synonymous_variant 0.21 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762200 c.2394C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>T synonymous_variant 0.23 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.18 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.17 rifampicin
rpoC 762794 c.-576C>G upstream_gene_variant 0.17 rifampicin
rpoB 762795 p.Asp997Asn missense_variant 0.18 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.17 rifampicin Uncertain significance
rpoC 762803 c.-567C>T upstream_gene_variant 0.17 rifampicin
rpoB 762812 c.3006C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.18 rifampicin
rpoB 762827 c.3021G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762868 p.Tyr1021Phe missense_variant 0.16 rifampicin
rpoC 762920 c.-450C>G upstream_gene_variant 0.23 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.24 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.18 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.19 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.21 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763900 c.531G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763939 c.570G>A synonymous_variant 0.21 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.16 rifampicin
rpoC 763999 c.630C>T synonymous_variant 0.17 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.16 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764167 c.798G>A synonymous_variant 0.21 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.2 rifampicin
rpoC 764195 p.Ser276Asn missense_variant 0.19 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.19 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.16 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.17 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.16 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.18 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>C synonymous_variant 0.21 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.21 rifampicin
rpoC 764932 c.1563C>G synonymous_variant 0.19 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765625 c.2256C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765772 c.2403C>G synonymous_variant 0.19 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.18 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.18 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.17 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.17 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.19 rifampicin
rpoC 765814 c.2445A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.19 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.2 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765961 c.2592G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.19 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.22 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.23 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.24 rifampicin
rpoC 766035 p.His889Arg missense_variant 0.25 rifampicin Uncertain significance
rpoC 766043 p.Gln892Glu missense_variant 0.25 rifampicin
rpoC 766061 p.Val898Met missense_variant 0.22 rifampicin
rpoC 766072 c.2703G>C synonymous_variant 0.2 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.19 rifampicin
rpoC 766309 c.2940G>A synonymous_variant 0.17 rifampicin
rpoC 766312 c.2943T>C synonymous_variant 0.17 rifampicin
rpoC 766336 c.2967C>G synonymous_variant 0.18 rifampicin
rpoC 766345 c.2976T>G synonymous_variant 0.18 rifampicin
rpoC 766351 c.2982C>G synonymous_variant 0.19 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.2 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.21 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.2 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.23 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.2 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.24 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.2 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.18 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.17 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.15 rifampicin
rpoC 766526 p.Val1053Ile missense_variant 0.15 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.15 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.16 rifampicin
rpoC 766651 c.3282T>G synonymous_variant 0.16 rifampicin
rpoC 766703 p.Met1112Leu missense_variant 0.19 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.21 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.22 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.22 rifampicin
rpoC 766744 c.3375G>A synonymous_variant 0.22 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.2 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.21 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.23 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.23 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.24 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.24 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.28 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.33 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767020 c.3651C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.29 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.25 rifampicin
rpoC 767065 c.3696G>C synonymous_variant 0.25 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.21 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767163 p.Asn1265Ser missense_variant 0.21 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767185 c.3816G>T synonymous_variant 0.21 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.21 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781808 c.249C>T synonymous_variant 0.2 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.21 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.22 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.23 streptomycin
rpsL 781838 c.279G>T synonymous_variant 0.22 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.21 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.2 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.19 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.16 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.15 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.15 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.15 streptomycin
rplC 801249 c.441T>G synonymous_variant 0.16 linezolid
rplC 801252 c.444G>C synonymous_variant 0.17 linezolid
rplC 801255 c.447C>A synonymous_variant 0.16 linezolid
rplC 801270 c.462T>C synonymous_variant 0.17 linezolid
rplC 801276 c.468G>C synonymous_variant 0.17 linezolid
rplC 801282 c.474G>C synonymous_variant 0.18 linezolid
rplC 801288 c.480G>C synonymous_variant 0.19 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303455 c.525C>G synonymous_variant 0.18 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303464 c.534A>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303470 c.540T>G synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303476 c.546G>C synonymous_variant 0.15 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303539 c.609G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303689 c.759T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303704 c.774T>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Ala missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.2 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303761 c.831T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303788 c.858T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303794 c.864A>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303812 c.882C>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303821 c.891C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303842 c.912C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303869 c.939T>C synonymous_variant 0.18 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303884 c.954T>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303897 c.967C>T synonymous_variant 0.19 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303905 c.975G>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303908 c.978C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303923 c.993C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303932 c.1002G>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303947 c.1017T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303948 p.Gly340Arg missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303961 p.Arg344Leu missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303965 c.1035G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303969 p.Val347Ile missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303981 p.Val351Ile missense_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304001 c.1071C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304022 c.1092T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304025 c.1095C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304037 c.1107G>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
Rv1258c 1406760 c.580_581insC frameshift_variant 0.98 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474060 n.403G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474089 n.432C>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474758 n.1101G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid Uncertain significance
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674507 c.306G>A synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674561 c.360C>T synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674690 c.489C>G synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674714 c.513C>G synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674726 c.525G>C synonymous_variant 0.21 isoniazid
ethionamide
inhA 1674732 c.531C>T synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674750 c.549T>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674756 c.555T>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674768 c.567T>G synonymous_variant 0.28 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674774 c.573A>G synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674777 c.576C>G synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674780 c.579T>G synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674801 c.600T>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674816 c.615T>G synonymous_variant 0.22 isoniazid
ethionamide
rpsA 1833724 c.183C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833772 c.231C>T synonymous_variant 0.15 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.15 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834249 c.708T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834303 c.762T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834499 c.958C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834556 p.Ala339Thr missense_variant 0.26 pyrazinamide Uncertain significance
rpsA 1834609 c.1068T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.23 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.17 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.15 isoniazid
kasA 2518249 c.135A>T synonymous_variant 0.15 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.18 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.15 isoniazid
eis 2714846 p.Val163Ile missense_variant 1.0 kanamycin Not assoc w R
amikacin Not assoc w R
folC 2746576 c.1023C>G synonymous_variant 0.16 para-aminosalicylic_acid
folC 2746594 c.1005T>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2746609 c.990T>C synonymous_variant 0.23 para-aminosalicylic_acid
folC 2746612 c.987C>T synonymous_variant 0.23 para-aminosalicylic_acid
folC 2746631 p.Gly323Ile missense_variant 0.25 para-aminosalicylic_acid
folC 2746645 c.954G>A synonymous_variant 0.28 para-aminosalicylic_acid
folC 2746657 c.942T>C synonymous_variant 0.27 para-aminosalicylic_acid
folC 2746663 c.936T>C synonymous_variant 0.29 para-aminosalicylic_acid
folC 2746677 p.Ser308Ala missense_variant 0.28 para-aminosalicylic_acid
folC 2746678 c.921T>G synonymous_variant 0.28 para-aminosalicylic_acid
folC 2746684 c.915C>G synonymous_variant 0.28 para-aminosalicylic_acid
folC 2746687 c.912C>G synonymous_variant 0.28 para-aminosalicylic_acid
folC 2746693 c.906G>C synonymous_variant 0.26 para-aminosalicylic_acid
folC 2746714 c.885T>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2746728 c.871T>C synonymous_variant 0.22 para-aminosalicylic_acid
folC 2746741 c.858C>T synonymous_variant 0.18 para-aminosalicylic_acid
folC 2746744 c.855T>G synonymous_variant 0.18 para-aminosalicylic_acid
Rv2477c 2783116 c.927T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783203 c.840C>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783206 c.837G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783419 c.624G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783428 c.615C>T synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783432 p.Ser204Thr missense_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783482 c.561C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783695 c.348C>T synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783722 c.321C>A synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783767 c.276C>T synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783959 c.84C>T synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783962 c.81T>C synonymous_variant 0.18 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
pepQ 2859747 c.672C>G synonymous_variant 0.17 bedaquiline
clofazimine
pepQ 2859750 c.669C>G synonymous_variant 0.16 bedaquiline
clofazimine
pepQ 2859765 c.654G>C synonymous_variant 0.19 bedaquiline
clofazimine
pepQ 2859780 c.639G>A synonymous_variant 0.17 bedaquiline
clofazimine
pepQ 2859801 c.618G>C synonymous_variant 0.19 bedaquiline
clofazimine
pepQ 2859825 c.594C>G synonymous_variant 0.16 bedaquiline
clofazimine
pepQ 2859843 c.576G>C synonymous_variant 0.17 bedaquiline
clofazimine
pepQ 2859852 c.567A>G synonymous_variant 0.17 bedaquiline
clofazimine
pepQ 2859855 p.Val188Ile missense_variant 0.17 bedaquiline
clofazimine
pepQ 2859864 c.555T>C synonymous_variant 0.17 bedaquiline
clofazimine
pepQ 2859870 c.549T>C synonymous_variant 0.17 bedaquiline
clofazimine
pepQ 2859873 c.546T>C synonymous_variant 0.18 bedaquiline
clofazimine
pepQ 2859885 c.534C>G synonymous_variant 0.17 bedaquiline
clofazimine
pepQ 2859894 p.Glu175Asp missense_variant 0.16 bedaquiline
clofazimine
thyA 3073977 c.495A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074034 c.438T>C synonymous_variant 0.19 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3624032 c.879T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624077 c.834G>T synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624082 c.829A>C synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624094 c.817A>C synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624100 c.811T>C synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624101 c.810C>G synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624107 c.804C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624125 c.786A>G synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624143 c.768T>C synonymous_variant 0.25 rifampicin
bedaquiline
lpqB 3624166 p.Met249Leu missense_variant 0.19 rifampicin
bedaquiline
lpqB 3624172 p.Val247Ile missense_variant 0.16 rifampicin
bedaquiline
lpqB 3624173 c.738A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624204 p.Ser236Asn missense_variant 0.16 rifampicin
bedaquiline
lpqB 3624209 c.702A>C synonymous_variant 0.16 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625087 p.Ala509Ser missense_variant 0.2 rifampicin
bedaquiline
lpqB 3625096 c.-186C>T upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625102 c.-192A>G upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625114 c.-204G>A upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625117 c.-207T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625123 c.-213T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625134 c.-224T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625135 c.-225A>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625138 c.-228C>G upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625141 c.-231T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625147 c.-237C>G upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625161 c.-251T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3625162 c.1452T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
lpqB 3625186 c.-276T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625195 c.-285A>G upstream_gene_variant 0.25 rifampicin
bedaquiline
lpqB 3625201 c.-291T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3625204 p.Ser470Ala missense_variant 0.24 rifampicin
bedaquiline
lpqB 3625207 c.-297C>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625222 c.1392T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625240 c.-330T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625243 c.-333T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3625267 c.1347T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625615 c.-705G>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625627 c.-717C>T upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3625636 p.Ala326Glu missense_variant 0.17 rifampicin
bedaquiline
lpqB 3625648 c.-738T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625654 c.-746_-744delTTGinsCTC upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625663 c.-753G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625683 c.-773C>T upstream_gene_variant 0.22 rifampicin
bedaquiline
lpqB 3625690 c.-780T>G upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625720 c.-810G>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625747 c.867G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.27 rifampicin Uncertain significance
bedaquiline
mtrB 3625762 c.852A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625771 c.843C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625796 p.Val273Glu missense_variant 0.25 rifampicin
bedaquiline
lpqB 3625798 c.-888G>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626101 p.Gln171His missense_variant 0.17 rifampicin
bedaquiline
mtrB 3626239 c.375T>C synonymous_variant 0.16 rifampicin
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626704 c.-91C>T upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3626723 c.627C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626726 c.-113T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626729 c.-116G>A upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3626780 c.-167T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626798 c.-185T>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3626956 p.Ser132Ala missense_variant 0.29 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627073 c.277C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrA 3627080 c.270T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
fbiB 3640878 c.-657T>C upstream_gene_variant 0.15 pretomanid
delamanid
clofazimine
rpoA 3877613 p.Ile299Val missense_variant 0.16 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.18 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.18 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.18 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.19 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.19 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>C synonymous_variant 0.19 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.19 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.23 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.21 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.19 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.18 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.18 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.2 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>T synonymous_variant 0.19 rifampicin
rpoA 3878175 c.333G>C synonymous_variant 0.19 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.19 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>T synonymous_variant 0.18 rifampicin
rpoA 3878253 c.255G>T synonymous_variant 0.16 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.18 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.2 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.19 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878358 c.150C>A synonymous_variant 0.21 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.22 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.24 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.23 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.23 rifampicin
rpoA 3878403 c.105C>T synonymous_variant 0.21 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.21 rifampicin
rpoA 3878433 c.75G>A synonymous_variant 0.16 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.18 rifampicin
rpoA 3878458 p.Asn17Ser missense_variant 0.18 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.2 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.21 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.26 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878749 c.-242G>C upstream_gene_variant 0.26 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.25 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.25 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878791 c.-284C>T upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878800 c.-293G>A upstream_gene_variant 0.27 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.28 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.28 rifampicin
rpoA 3878826 c.-319A>T upstream_gene_variant 0.26 rifampicin
rpoA 3878832 c.-325C>G upstream_gene_variant 0.25 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.25 rifampicin
rpoA 3878838 c.-331A>C upstream_gene_variant 0.27 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.25 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878884 c.-377C>T upstream_gene_variant 0.2 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.19 rifampicin
rpoA 3878894 c.-387A>G upstream_gene_variant 0.19 rifampicin
rpoA 3878908 c.-402_-401delACinsCG upstream_gene_variant 0.17 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878935 c.-428C>T upstream_gene_variant 0.18 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.18 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878953 c.-446C>G upstream_gene_variant 0.16 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878974 c.-467C>G upstream_gene_variant 0.16 rifampicin
rpoA 3878991 c.-484C>A upstream_gene_variant 0.17 rifampicin
rpoA 3878995 c.-488A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3879061 c.-554C>G upstream_gene_variant 0.18 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879085 c.-578C>T upstream_gene_variant 0.17 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.17 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.19 rifampicin
ddn 3986622 c.-222C>T upstream_gene_variant 0.19 pretomanid
delamanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.17 pretomanid
delamanid
clpC1 4038461 c.2244G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038475 p.Ser744Gly missense_variant 0.19 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.17 pyrazinamide
clpC1 4038491 c.2214C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.17 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.17 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039040 c.1665C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039073 c.1632C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039250 c.1455C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039289 c.1416T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039394 c.1311G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.22 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039439 c.1266C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.2 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039592 c.1113G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039715 c.990G>A synonymous_variant 0.15 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.21 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039823 c.882T>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039831 c.874T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.22 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040204 c.501G>T synonymous_variant 0.2 pyrazinamide
clpC1 4040210 c.495G>T synonymous_variant 0.17 pyrazinamide
clpC1 4040213 c.492T>G synonymous_variant 0.18 pyrazinamide
clpC1 4040222 c.483G>A synonymous_variant 0.18 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.19 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040231 c.474C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.19 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.21 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040309 c.396C>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040318 c.387C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040326 c.379C>T synonymous_variant 0.2 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.2 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.23 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.22 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040447 c.258G>A synonymous_variant 0.2 pyrazinamide
clpC1 4040459 c.246C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
embC 4240175 c.313T>C synonymous_variant 0.16 ethambutol
embC 4240178 c.316T>C synonymous_variant 0.16 ethambutol
embC 4240183 c.321A>C synonymous_variant 0.18 ethambutol
embC 4240213 c.351C>G synonymous_variant 0.17 ethambutol
embC 4240216 c.354T>C synonymous_variant 0.16 ethambutol
embC 4240219 c.357C>G synonymous_variant 0.17 ethambutol
embC 4240229 p.Leu123Ile missense_variant 0.17 ethambutol
embC 4240233 p.Gln124Leu missense_variant 0.17 ethambutol
embC 4240237 c.375G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4240249 p.Asp129Glu missense_variant 0.21 ethambutol
embC 4240258 c.396T>G synonymous_variant 0.23 ethambutol
embC 4240267 c.405T>A synonymous_variant 0.2 ethambutol
embC 4240270 c.408T>C synonymous_variant 0.21 ethambutol
embC 4240277 p.Leu139Val missense_variant 0.21 ethambutol
embC 4240288 c.426C>G synonymous_variant 0.22 ethambutol
embC 4240297 c.435T>C synonymous_variant 0.19 ethambutol
embC 4240307 p.Gly149Ser missense_variant 0.2 ethambutol Uncertain significance
embC 4240313 p.Thr151Ala missense_variant 0.22 ethambutol
embC 4240318 c.456T>C synonymous_variant 0.21 ethambutol
embC 4240348 c.486T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4240354 c.492C>G synonymous_variant 0.25 ethambutol
embC 4240355 p.Ala165Thr missense_variant 0.25 ethambutol Uncertain significance
embC 4240363 c.501A>G synonymous_variant 0.25 ethambutol
embC 4240372 c.510A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4240375 c.513G>C synonymous_variant 0.24 ethambutol
embC 4240376 p.Val172Thr missense_variant 0.24 ethambutol
embC 4240390 c.528T>C synonymous_variant 0.26 ethambutol
embC 4240393 c.531T>C synonymous_variant 0.26 ethambutol
embC 4240405 c.543T>C synonymous_variant 0.25 ethambutol
embC 4240406 p.Ala182Ser missense_variant 0.26 ethambutol
embC 4240420 c.558T>G synonymous_variant 0.32 ethambutol
embC 4240423 c.561G>A synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embC 4240444 c.582C>G synonymous_variant 0.29 ethambutol
embC 4240471 c.609C>T synonymous_variant 0.26 ethambutol
embC 4240475 p.Ala205Ser missense_variant 0.24 ethambutol Uncertain significance
embC 4240480 c.618G>C synonymous_variant 0.23 ethambutol
embC 4240486 c.624G>A synonymous_variant 0.24 ethambutol
embC 4240489 c.627A>G synonymous_variant 0.24 ethambutol
embC 4240495 c.633T>G synonymous_variant 0.23 ethambutol
embC 4240496 c.634C>T synonymous_variant 0.23 ethambutol
embC 4240512 p.Ser217Thr missense_variant 0.22 ethambutol
embC 4240516 c.654G>C synonymous_variant 0.22 ethambutol
embC 4240519 c.657T>C synonymous_variant 0.21 ethambutol
embC 4240945 c.1083T>C synonymous_variant 0.15 ethambutol
embC 4240957 c.1095C>G synonymous_variant 0.18 ethambutol
embC 4240981 c.1119G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4240983 p.Ser374Asn missense_variant 0.21 ethambutol
embC 4240990 c.1128A>C synonymous_variant 0.21 ethambutol
embC 4241002 c.1140G>C synonymous_variant 0.21 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.22 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.22 ethambutol
embC 4241030 c.1168C>T synonymous_variant 0.26 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.27 ethambutol
embC 4241056 c.1194C>G synonymous_variant 0.3 ethambutol
embC 4241062 c.1200G>C synonymous_variant 0.3 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.31 ethambutol
embC 4241074 c.1212G>C synonymous_variant 0.32 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embC 4241110 c.1248G>C synonymous_variant 0.3 ethambutol
embC 4241123 c.1261C>A synonymous_variant 0.28 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embC 4241143 p.Ile427Met missense_variant 0.28 ethambutol
embC 4241153 p.Ile431Leu missense_variant 0.27 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.29 ethambutol
embC 4241162 c.1300_1302delTTGinsCTC synonymous_variant 0.27 ethambutol
embC 4241179 c.1317G>C synonymous_variant 0.26 ethambutol
embC 4241185 c.1323G>C synonymous_variant 0.26 ethambutol
embC 4241188 c.1326C>G synonymous_variant 0.27 ethambutol
embC 4241219 p.Ile453Val missense_variant 0.19 ethambutol
embC 4241224 c.1362G>C synonymous_variant 0.18 ethambutol
embC 4241230 c.1368A>G synonymous_variant 0.17 ethambutol
embC 4241413 c.1551C>T synonymous_variant 0.15 ethambutol
embC 4241485 c.1623G>C synonymous_variant 0.18 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.2 ethambutol
embC 4241498 p.Val546Ile missense_variant 0.2 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.21 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241530 c.1668C>G synonymous_variant 0.2 ethambutol
embC 4241536 c.1674A>G synonymous_variant 0.2 ethambutol
embC 4241539 c.1677T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241545 c.1683T>C synonymous_variant 0.18 ethambutol
embC 4241547 p.Ala562Val missense_variant 0.17 ethambutol
embC 4241551 c.1689A>G synonymous_variant 0.19 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.18 ethambutol
embC 4241593 c.1731C>G synonymous_variant 0.18 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.17 ethambutol
embC 4241623 c.1761C>G synonymous_variant 0.15 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.16 ethambutol
embC 4241648 c.1786T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 0.99 ethambutol Not assoc w R
embA 4244714 c.1482C>G synonymous_variant 0.18 ethambutol
embA 4244738 c.1506C>T synonymous_variant 0.16 ethambutol
embA 4245032 c.1800A>C synonymous_variant 0.15 ethambutol
embA 4245041 c.1809C>G synonymous_variant 0.17 ethambutol
embA 4245053 c.1821G>C synonymous_variant 0.17 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.17 ethambutol
embA 4245083 c.1851A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embA 4245131 c.1899G>A synonymous_variant 0.88 ethambutol Not assoc w R - Interim
embB 4245725 c.-789A>G upstream_gene_variant 0.16 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.17 ethambutol
embB 4245743 c.-771C>G upstream_gene_variant 0.17 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.17 ethambutol
embA 4245771 p.Asn847Ser missense_variant 0.17 ethambutol Uncertain significance
embB 4245782 c.-732C>G upstream_gene_variant 0.19 ethambutol
embB 4245788 c.-726C>G upstream_gene_variant 0.19 ethambutol
embB 4245807 c.-707_-705delTTAinsCTG upstream_gene_variant 0.21 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.19 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.17 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.17 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.16 ethambutol
embB 4247566 c.1053C>G synonymous_variant 0.17 ethambutol
embB 4247572 c.1059A>C synonymous_variant 0.16 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.18 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.18 ethambutol
embB 4248115 c.1602C>T synonymous_variant 0.79 ethambutol Not assoc w R
embB 4248130 c.1617G>C synonymous_variant 0.2 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.19 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.2 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.2 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.16 ethambutol
aftB 4267547 c.1290C>G synonymous_variant 0.16 ethambutol
aftB 4267556 c.1281G>C synonymous_variant 0.17 ethambutol
aftB 4267559 c.1278C>G synonymous_variant 0.18 ethambutol
aftB 4267580 c.1257G>C synonymous_variant 0.19 ethambutol
aftB 4267592 c.1245C>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
aftB 4267647 p.Asp397Gly missense_variant 0.89 ethambutol Not assoc w R
aftB 4268994 c.-158T>C upstream_gene_variant 0.16 ethambutol
ubiA 4268999 p.Leu279Val missense_variant 0.17 ethambutol
aftB 4269006 c.-170T>C upstream_gene_variant 0.18 ethambutol
aftB 4269012 c.-176G>C upstream_gene_variant 0.19 ethambutol
aftB 4269018 c.-182G>C upstream_gene_variant 0.19 ethambutol
aftB 4269027 c.-191C>A upstream_gene_variant 0.24 ethambutol
aftB 4269033 c.-197T>C upstream_gene_variant 0.27 ethambutol
aftB 4269042 c.-206G>C upstream_gene_variant 0.26 ethambutol
aftB 4269048 c.-212C>T upstream_gene_variant 0.3 ethambutol
ubiA 4269075 p.Ile253Val missense_variant 0.32 ethambutol
aftB 4269084 c.-248G>C upstream_gene_variant 0.29 ethambutol
ubiA 4269099 c.735G>A synonymous_variant 0.24 ethambutol Not assoc w R - Interim
aftB 4269102 c.-268_-266delAGCinsTCG upstream_gene_variant 0.25 ethambutol
ubiA 4269107 p.Tyr243His missense_variant 0.26 ethambutol
ubiA 4269110 p.Gly242Arg missense_variant 0.26 ethambutol
aftB 4269123 c.-287T>G upstream_gene_variant 0.28 ethambutol
aftB 4269138 c.-302C>T upstream_gene_variant 0.26 ethambutol
ubiA 4269143 p.Leu231Val missense_variant 0.25 ethambutol
ubiA 4269144 c.690C>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
aftB 4269153 c.-317C>G upstream_gene_variant 0.27 ethambutol
aftB 4269156 c.-320C>G upstream_gene_variant 0.27 ethambutol
aftB 4269177 c.-341G>C upstream_gene_variant 0.27 ethambutol
aftB 4269183 c.-347T>C upstream_gene_variant 0.26 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.24 ethambutol
ubiA 4269209 p.Ser209Ala missense_variant 0.22 ethambutol
ubiA 4269219 p.Ala205Arg missense_variant 0.22 ethambutol
ubiA 4269222 c.612T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
aftB 4269234 c.-398A>G upstream_gene_variant 0.22 ethambutol
ubiA 4269240 p.Leu198Val missense_variant 0.22 ethambutol Uncertain significance
ubiA 4269243 p.His197Gln missense_variant 0.22 ethambutol
aftB 4269285 c.-449T>G upstream_gene_variant 0.2 ethambutol
aftB 4269288 c.-452C>T upstream_gene_variant 0.2 ethambutol
aftB 4269291 c.-455A>G upstream_gene_variant 0.21 ethambutol
ubiA 4269296 p.Met180Val missense_variant 0.21 ethambutol Uncertain significance
ubiA 4269299 p.Ile179Phe missense_variant 0.21 ethambutol
ubiA 4269312 p.Lys174Gln missense_variant 0.17 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R