TB-Profiler result

Run: ERR4816548
Summary

Run ID: ERR4816548

Sample name:

Date: 2024-04-16T04:57:30.596472

Number of reads: 659195

Percentage reads mapped: 26.96

Median coverage: 14.0

Strain: lineage4.5

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.5 Euro-American RD122 1.0
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
inhA 1673425 c.-777C>T upstream_gene_variant 1.0 isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethionamide Assoc w R Alias fabG1_c.-15C>T
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7892 c.591G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.4 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8316 p.Thr339Tyr missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8320 p.Ser340Asn missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8329 p.Ala343Val missense_variant 0.38 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 8343 c.1042_1044delATCinsCG frameshift_variant&missense_variant 0.4 levofloxacin
moxifloxacin
gyrA 8354 c.1053G>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
nusG 734497 c.244_246delGTGinsAC frameshift_variant&missense_variant 0.2 rifampicin
nusG 734505 c.252G>T synonymous_variant 0.31 rifampicin
nusG 734508 c.255C>G synonymous_variant 0.29 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734553 c.300C>G synonymous_variant 0.28 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.27 rifampicin
nusG 734565 c.312G>C synonymous_variant 0.32 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760157 c.351A>G synonymous_variant 0.38 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.53 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760206 p.Ile134Val missense_variant 0.47 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.48 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760262 c.456G>C synonymous_variant 0.5 rifampicin
rpoB 760263 p.Met153Val missense_variant 0.5 rifampicin Uncertain significance
rpoB 760274 p.Glu156Asp missense_variant 0.59 rifampicin Uncertain significance
rpoB 760298 c.492G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.57 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.54 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.53 rifampicin
rpoB 760317 c.511_512delAGinsTC synonymous_variant 0.53 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760340 c.534G>C synonymous_variant 0.54 rifampicin
rpoB 760353 p.Glu183Gln missense_variant 0.36 rifampicin
rpoB 760356 p.Thr184Ala missense_variant 0.35 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.25 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.25 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760965 c.1159_1161delATGinsCC frameshift_variant&missense_variant 0.36 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.49 rifampicin Uncertain significance
rpoB 762122 p.Asp772Glu missense_variant 0.55 rifampicin
rpoB 762125 p.Glu773Asp missense_variant 0.5 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.54 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.57 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.58 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762156 c.2350_2352delGTGinsAC frameshift_variant&missense_variant 0.62 rifampicin
rpoB 762176 c.2370T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.65 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.68 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.69 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762318 p.Ser838Thr missense_variant 0.63 rifampicin
rpoB 762329 c.2523G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.59 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.52 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.5 rifampicin
rpoB 762359 p.Asp851Glu missense_variant 0.45 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.43 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762858 c.3052_3054delACGinsGC frameshift_variant&missense_variant 0.32 rifampicin
rpoB 762863 c.3057T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762878 p.Ile1024Met missense_variant 0.48 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.48 rifampicin Uncertain significance
rpoB 762894 p.Leu1030Met missense_variant 0.52 rifampicin
rpoB 762917 c.3111C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 762920 c.-450C>G upstream_gene_variant 0.64 rifampicin
rpoC 762926 c.-444C>G upstream_gene_variant 0.64 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.57 rifampicin
rpoB 762959 c.3153G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.57 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.53 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.32 rifampicin
rpoC 763504 c.135C>A synonymous_variant 0.42 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.52 rifampicin
rpoC 763528 c.159G>T synonymous_variant 0.58 rifampicin
rpoC 763534 c.165T>C synonymous_variant 0.62 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.63 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763606 c.237C>T synonymous_variant 0.8 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>G synonymous_variant 0.77 rifampicin
rpoC 763621 c.252C>T synonymous_variant 0.77 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.57 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.52 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763744 c.375G>C synonymous_variant 0.46 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.39 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.54 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.56 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>A synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>G synonymous_variant 0.65 rifampicin
rpoC 764548 c.1179G>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764551 c.1182G>C synonymous_variant 0.65 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.67 rifampicin
rpoC 764560 c.1191T>G synonymous_variant 0.68 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.65 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764660 c.1291_1293delGTGinsAC frameshift_variant&missense_variant 0.7 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764705 p.Leu446Asp missense_variant 0.59 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764737 c.1368G>C synonymous_variant 0.44 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764896 c.1527C>T synonymous_variant 0.24 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.25 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.24 rifampicin Uncertain significance
rpoC 764935 c.1566T>C synonymous_variant 0.25 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.26 rifampicin
rpoC 764956 c.1587T>C synonymous_variant 0.3 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764971 c.1602C>G synonymous_variant 0.29 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>C synonymous_variant 0.62 rifampicin
rpoC 767015 p.Ala1216Thr missense_variant 0.59 rifampicin
rpoC 767020 c.3651C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 767038 c.3669G>C synonymous_variant 0.56 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>T synonymous_variant 0.48 rifampicin
rpoC 767065 c.3696G>C synonymous_variant 0.48 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.4 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776922 p.Ala520Val missense_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781802 c.243G>C synonymous_variant 0.38 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.39 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.38 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.35 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.38 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.43 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.45 streptomycin
rpsL 781851 c.292_294delATCinsGT frameshift_variant&missense_variant 0.48 streptomycin Uncertain significance
rpsL 781865 c.306G>C synonymous_variant 0.6 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.56 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.57 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.48 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.43 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.43 streptomycin
rpsL 781907 c.348T>G synonymous_variant 0.42 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.35 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.29 streptomycin
rplC 800693 c.-116A>G upstream_gene_variant 0.4 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.42 linezolid
rplC 800715 c.-94_-92delATCinsGG upstream_gene_variant 0.47 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.5 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.47 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.38 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.38 linezolid
Rv1258c 1406101 p.Pro414Ser missense_variant 1.0 streptomycin Uncertain significance
isoniazid Not assoc w R
pyrazinamide Not assoc w R - Interim
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472123 n.278A>G non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472474 n.629C>G non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472485 n.640delGinsTC non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472494 n.649A>T non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472583 n.738T>A non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472647 n.802C>T non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472675 n.830T>G non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472677 n.832C>T non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472678 n.833T>G non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472685 n.840G>T non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472687 n.842A>C non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472843 n.998_999insT non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1005delT non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472959 n.1114T>C non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473094 n.1249T>G non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473147 n.1302G>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473164 n.1319C>G non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473287 n.1442_1443delCCinsTCT non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473292 n.1447_1448insA non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474163 n.506C>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>G non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474220 n.563G>A non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474406 n.749T>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474628 n.971C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474629 n.972G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474638 n.981C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1474643 n.986A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474658 n.1001A>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474798 n.1141C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474806 n.1149A>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475115 n.1458A>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475116 n.1459G>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475153 n.1496A>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475171 n.1514C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475542 n.1885A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475571 n.1914A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475688 n.2031G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475696 n.2039T>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid
rrl 1475703 n.2046A>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475707 n.2050T>G non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475713 n.2056C>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1475740 n.2083G>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1475761 n.2104_2108delCGCAAinsATTTCG non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475788 n.2131C>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1475880 n.2223C>T non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475883 n.2226A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.54 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475990 n.2333G>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476040 n.2383C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476081 n.2424A>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1476082 n.2425T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476087 n.2430C>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.43 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.41 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476196 n.2539C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476255 n.2598A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.51 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1476301 n.2644A>G non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.84 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1476534 n.2877A>C non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833874 c.333T>C synonymous_variant 0.39 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.41 pyrazinamide
rpsA 1833914 c.373_375delGCCinsCG frameshift_variant&missense_variant 0.44 pyrazinamide Uncertain significance
rpsA 1833928 c.387G>C synonymous_variant 0.44 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.49 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.51 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.52 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.54 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.61 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.6 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.61 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.57 pyrazinamide
rpsA 1834040 p.Lys167Arg missense_variant 0.51 pyrazinamide
rpsA 1834046 p.Ile169Leu missense_variant 0.51 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834219 c.678C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834255 c.714C>G synonymous_variant 0.56 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.43 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834307 c.766_768delGACinsCG frameshift_variant&missense_variant 0.42 pyrazinamide Uncertain significance
rpsA 1834318 c.777C>G synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834327 c.786G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834333 p.Asp264Glu missense_variant 0.38 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.48 pyrazinamide Uncertain significance
rpsA 1834456 c.915T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.48 pyrazinamide
tsnR 1853597 c.-9G>C upstream_gene_variant 1.0 linezolid Uncertain significance
ndh 2103101 c.-59C>A upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv2681 2997606 p.Val290Ile missense_variant 1.0 capreomycin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625297 c.1317C>T synonymous_variant 1.0 bedaquiline
rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877667 p.Ser281Ala missense_variant 0.32 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.32 rifampicin
rpoA 3877672 p.Thr279Ser missense_variant 0.32 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.33 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877695 c.813C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877701 c.805_807delGTGinsAT frameshift_variant&missense_variant 0.32 rifampicin
rpoA 3877950 c.558C>G synonymous_variant 0.54 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.3 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.25 rifampicin
rpoA 3878259 c.249G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878262 p.Ser82Glu missense_variant 0.26 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
clpC1 4038318 p.Pro796Leu missense_variant 1.0 pyrazinamide Not assoc w R
clpC1 4038755 c.1950G>T synonymous_variant 0.46 pyrazinamide
clpC1 4038764 c.1941C>G synonymous_variant 0.48 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.46 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.46 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.48 pyrazinamide
clpC1 4038794 p.Ser637Thr missense_variant 0.55 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.57 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.57 pyrazinamide
clpC1 4038839 c.1866G>C synonymous_variant 0.5 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4038863 c.1842G>C synonymous_variant 0.43 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
clpC1 4038881 c.1824C>T synonymous_variant 0.67 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.58 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.42 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.48 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.48 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.58 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.52 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.54 pyrazinamide
clpC1 4038939 p.Phe589Tyr missense_variant 0.54 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.54 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.58 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.58 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.67 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.61 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
clpC1 4038986 p.Asp573Glu missense_variant 0.63 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.66 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.63 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.66 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.7 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.68 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.58 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.56 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.56 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039117 p.Lys530Gln missense_variant 0.44 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039121 c.1584T>G synonymous_variant 0.48 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.48 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.36 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.59 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.7 pyrazinamide
clpC1 4039561 p.Ala382Ser missense_variant 0.66 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.66 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.64 pyrazinamide Uncertain significance
clpC1 4039571 c.1134G>A synonymous_variant 0.64 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.66 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.66 pyrazinamide Not assoc w R - Interim
clpC1 4039610 c.1095G>C synonymous_variant 0.68 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.75 pyrazinamide
clpC1 4039649 c.1054_1056delGTGinsCC frameshift_variant&missense_variant 0.75 pyrazinamide
clpC1 4039654 p.Thr351Ser missense_variant 0.78 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.77 pyrazinamide
clpC1 4039670 c.1033_1035delGTGinsAC frameshift_variant&missense_variant 0.71 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.45 pyrazinamide
clpC1 4039727 p.Asp326Glu missense_variant 0.42 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039901 c.804C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039937 c.768G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.26 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039973 p.Asp244Glu missense_variant 0.49 pyrazinamide
clpC1 4040000 c.703_705delCACinsAG frameshift_variant&missense_variant 0.56 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.55 pyrazinamide
clpC1 4040010 p.Ala232Asn missense_variant 0.58 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.67 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.7 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.68 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
clpC1 4040066 c.639G>C synonymous_variant 0.65 pyrazinamide
ethA 4326367 c.1107C>T synonymous_variant 1.0 ethionamide Not assoc w R - Interim
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin