TB-Profiler result

Run: ERR4817069
Summary

Run ID: ERR4817069

Sample name:

Date: 2024-05-22T14:08:19.203738

Number of reads: 383556

Percentage reads mapped: 23.5

Median coverage: 12.0

Strain:

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1 Indo-Oceanic RD239 1.0
lineage1.2.1.2.1 Indo-Oceanic RD239 1.0
lineage1.2.1 Indo-Oceanic RD239 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser441Ala Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Leu464Met Mutation from literature
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.799C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761127 p.Ser441Ala missense_variant 0.69 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761196 p.Leu464Met missense_variant 0.66 rifampicin Mutation from literature
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.92 amikacin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.8 kanamycin Assoc w R
capreomycin Assoc w R
amikacin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6112 p.Met291Ile missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8452 p.Ala384Val missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9260 c.1959G>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
nusG 734116 c.-138T>C upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760982 c.1176G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.5 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761030 c.1224G>C synonymous_variant 0.69 rifampicin
rpoB 761036 c.1230G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.67 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.69 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.7 rifampicin
rpoB 761126 c.1320G>C synonymous_variant 0.69 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761156 c.1350G>C synonymous_variant 0.65 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 761174 c.1368T>C synonymous_variant 0.64 rifampicin
rpoB 761177 c.1371G>C synonymous_variant 0.64 rifampicin
rpoB 761180 c.1374A>G synonymous_variant 0.66 rifampicin
rpoB 761183 c.1377T>C synonymous_variant 0.66 rifampicin
rpoB 761186 p.Glu460Asp missense_variant 0.66 rifampicin Uncertain significance
rpoB 761192 c.1386C>G synonymous_variant 0.64 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.81 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.81 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761262 p.Pro486Ser missense_variant 0.68 rifampicin
rpoB 761288 c.1482G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 761289 p.Ser495Ala missense_variant 0.7 rifampicin
rpoB 761292 p.Val496Thr missense_variant 0.7 rifampicin
rpoB 761303 c.1497G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761304 p.Val500Ile missense_variant 0.68 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761333 c.1527G>C synonymous_variant 0.66 rifampicin
rpoB 762858 c.3052_3054delACGinsTC frameshift_variant&missense_variant 0.35 rifampicin
rpoC 762863 c.-507T>G upstream_gene_variant 0.35 rifampicin
rpoB 762870 p.Met1022Gln missense_variant 0.35 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.42 rifampicin Uncertain significance
rpoB 762887 c.3081G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 762938 c.-432G>C upstream_gene_variant 0.5 rifampicin
rpoC 762980 c.-390T>C upstream_gene_variant 0.5 rifampicin
rpoC 762983 c.-387C>T upstream_gene_variant 0.52 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763486 c.117T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763505 c.136C>T synonymous_variant 0.53 rifampicin
rpoC 763528 c.159G>T synonymous_variant 0.59 rifampicin
rpoC 763531 c.162G>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.61 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.64 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763578 p.Phe70Tyr missense_variant 0.72 rifampicin
rpoC 763609 c.240C>G synonymous_variant 0.78 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>G synonymous_variant 0.74 rifampicin
rpoC 763621 c.252C>T synonymous_variant 0.76 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>T synonymous_variant 0.79 rifampicin
rpoC 763672 c.303C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.77 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.74 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.74 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763729 c.360G>C synonymous_variant 0.71 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.7 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.69 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.64 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.58 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.52 rifampicin
rpoC 763772 p.Val135Met missense_variant 0.45 rifampicin
rpoC 764311 c.942C>G synonymous_variant 0.4 rifampicin
rpoC 764320 c.951C>T synonymous_variant 0.4 rifampicin
rpoC 764347 c.978G>C synonymous_variant 0.57 rifampicin
rpoC 764359 c.990C>G synonymous_variant 0.61 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.71 rifampicin
rpoC 764398 c.1029G>C synonymous_variant 0.74 rifampicin
rpoC 764404 c.1035C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCT frameshift_variant&missense_variant 0.71 rifampicin
rpoC 764441 c.1072_1074delATCinsCG frameshift_variant&missense_variant 0.7 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.7 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.7 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 0.71 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764470 c.1101C>G synonymous_variant 0.77 rifampicin
rpoC 764485 c.1116G>C synonymous_variant 0.78 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.81 rifampicin
rpoC 764507 p.Ala380Ser missense_variant 0.84 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.74 rifampicin
rpoC 764536 c.1167G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>G synonymous_variant 0.8 rifampicin
rpoC 764548 c.1179G>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764561 c.1192_1194delCCGinsGC frameshift_variant&missense_variant 0.79 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764572 c.1203G>C synonymous_variant 0.79 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.79 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.81 rifampicin
rpoC 764602 c.1233C>A synonymous_variant 0.82 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>C synonymous_variant 0.83 rifampicin
rpoC 764623 c.1254C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>G synonymous_variant 0.79 rifampicin
rpoC 764644 c.1275G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 764647 c.1278C>T synonymous_variant 0.71 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764653 c.1284G>C synonymous_variant 0.72 rifampicin
rpoC 764656 c.1287C>G synonymous_variant 0.73 rifampicin
rpoC 764665 c.1296C>G synonymous_variant 0.78 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764677 c.1308C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764706 p.Leu446Gln missense_variant 0.76 rifampicin Uncertain significance
rpoC 764746 c.1377G>C synonymous_variant 0.8 rifampicin
rpoC 764758 c.1389C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764767 c.1398G>T synonymous_variant 0.77 rifampicin
rpoC 764770 c.1401G>A synonymous_variant 0.76 rifampicin
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.78 rifampicin
rpoC 764804 c.1435_1437delCAGinsTC frameshift_variant&missense_variant 0.77 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.76 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.7 rifampicin
rpoC 764843 p.Ala492Thr missense_variant 0.68 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>T synonymous_variant 0.44 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.42 rifampicin
rpoC 764902 c.1533C>T synonymous_variant 0.38 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.33 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.33 rifampicin Uncertain significance
rpoC 764917 c.1548G>C synonymous_variant 0.33 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.28 rifampicin
rpoC 764948 c.1579_1581delTTGinsCC frameshift_variant&missense_variant 0.28 rifampicin
rpoC 764956 c.1587T>C synonymous_variant 0.26 rifampicin
rpoC 764958 p.Glu530Gly missense_variant 0.26 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764971 c.1602C>G synonymous_variant 0.28 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 0.22 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800357 c.-452C>A upstream_gene_variant 1.0 linezolid Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1258c 1406312 c.1029T>C synonymous_variant 1.0 streptomycin Not assoc w R
isoniazid Not assoc w R
pyrazinamide Not assoc w R
atpE 1460907 c.-138T>C upstream_gene_variant 0.92 bedaquiline
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.93 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472225 n.380C>G non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>C non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472293 n.448C>A non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsAA non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.82 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472845 n.1000G>C non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472846 n.1001C>G non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472859 n.1014G>T non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472863 n.1020_1021dupCC non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472873 n.1028_1029delCCinsGGCT non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.94 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.98 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473147 n.1302G>T non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473164 n.1319C>A non_coding_transcript_exon_variant 0.97 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473292 n.1447_1449delGGAinsTGGG non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474124 n.467G>C non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474125 n.468C>G non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474141 n.484G>C non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474142 n.485C>G non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474155 n.498G>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474450 n.793T>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474467 n.810A>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474633 n.977_981delTCACC non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474640 n.983_984insTTGCT non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474708 n.1051_1052insA non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474711 n.1054G>C non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474712 n.1055G>A non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474713 n.1056T>A non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474716 n.1059A>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.82 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.82 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1475757 n.2100_2101insG non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475760 n.2105_2106delGC non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475769 n.2112_2113insC non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.88 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.87 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.85 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.8 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1476519 n.2862C>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid Uncertain significance
inhA 1674162 c.-40C>T upstream_gene_variant 1.0 ethionamide Uncertain significance
isoniazid Not assoc w R
rpsA 1833970 c.429G>C synonymous_variant 0.76 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.78 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.74 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.76 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.76 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.74 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.74 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.76 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.74 pyrazinamide
rpsA 1834025 p.Gln162Ala missense_variant 0.74 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.72 pyrazinamide
rpsA 1834040 p.Lys167Gln missense_variant 0.72 pyrazinamide
rpsA 1834043 p.Glu168Gln missense_variant 0.72 pyrazinamide
rpsA 1834046 p.Ile169Leu missense_variant 0.7 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.69 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.5 pyrazinamide
rpsA 1834108 c.567C>A synonymous_variant 0.5 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.5 pyrazinamide
rpsA 1834219 c.678C>G synonymous_variant 0.5 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.53 pyrazinamide
rpsA 1834228 c.687C>T synonymous_variant 0.53 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834243 c.702G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.55 pyrazinamide
rpsA 1834285 c.744G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.5 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834307 c.766_768delGACinsCG frameshift_variant&missense_variant 0.44 pyrazinamide Uncertain significance
rpsA 1834312 c.771G>A synonymous_variant 0.44 pyrazinamide
rpsA 1834321 c.780C>G synonymous_variant 0.42 pyrazinamide
rpsA 1834327 c.786G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834330 c.789C>G synonymous_variant 0.42 pyrazinamide
tsnR 1853974 c.369C>T synonymous_variant 1.0 linezolid Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2519048 p.Gly312Ser missense_variant 0.93 isoniazid
Rv2477c 2783222 p.Arg274Gln missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin
streptomycin Uncertain significance
levofloxacin
kanamycin
rifampicin Uncertain significance
amikacin
clpC1 4039714 p.Tyr331His missense_variant 0.56 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.57 pyrazinamide
clpC1 4039730 c.975C>G synonymous_variant 0.6 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.61 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.67 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.67 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.76 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.76 pyrazinamide
clpC1 4039773 p.Lys311Met missense_variant 0.78 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.78 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.79 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.82 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.87 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.87 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.84 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCC frameshift_variant&missense_variant 0.82 pyrazinamide
clpC1 4039838 c.865_867delCTGinsAC frameshift_variant&missense_variant 0.84 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.79 pyrazinamide
clpC1 4039865 c.840T>G synonymous_variant 0.72 pyrazinamide
clpC1 4039875 p.Asn277Arg missense_variant 0.68 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.62 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCT synonymous_variant 0.65 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.64 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.64 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.64 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.68 pyrazinamide
clpC1 4039982 c.723G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.67 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.67 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.73 pyrazinamide
clpC1 4039997 c.708C>A synonymous_variant 0.73 pyrazinamide
clpC1 4040001 p.His235Arg missense_variant 0.73 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.75 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.75 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.73 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.73 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.73 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.73 pyrazinamide
clpC1 4040045 c.660C>G synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4040069 c.636G>C synonymous_variant 0.65 pyrazinamide
clpC1 4040087 c.618G>A synonymous_variant 0.5 pyrazinamide
clpC1 4040090 c.615T>G synonymous_variant 0.5 pyrazinamide
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4241042 p.Asn394Asp missense_variant 0.83 ethambutol Not assoc w R
embA 4244420 c.1188G>C synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245969 p.Pro913Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338361 p.Arg54Gln missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407873 c.330G>T synonymous_variant 1.0 streptomycin Not assoc w R