TB-Profiler result

Run: ERR4817069
Summary

Run ID: ERR4817069

Sample name:

Date: 01-04-2023 14:47:12

Number of reads: 383556

Percentage reads mapped: 23.5

Strain:

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage1 Indo-Oceanic EAI RD239 1.0
lineage1.2.1 Indo-Oceanic EAI2 RD239 1.0
lineage1.2.1.2.1 Indo-Oceanic NA RD239 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761127 p.Ser441Ala missense_variant 0.69 rifampicin
rpoB 761196 p.Leu464Met missense_variant 0.66 rifampicin
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.9 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.92 kanamycin, capreomycin, aminoglycosides, amikacin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.8 kanamycin, capreomycin, aminoglycosides, amikacin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6112 p.Met291Ile missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8452 p.Ala384Val missense_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 1.0
gyrA 9260 c.1959G>C synonymous_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575368 c.21T>C synonymous_variant 1.0
rpoB 760916 c.1110C>T synonymous_variant 0.25
rpoB 760920 p.Leu372Ile missense_variant 0.22
rpoB 760925 c.1119T>C synonymous_variant 0.22
rpoB 760926 p.Thr374Ala missense_variant 0.2
rpoB 760931 c.1125C>G synonymous_variant 0.2
rpoB 760944 p.Gln380Glu missense_variant 0.2
rpoB 760958 c.1152G>C synonymous_variant 0.18
rpoB 760959 p.Val385Thr missense_variant 0.18
rpoB 760965 p.Met387Leu missense_variant 0.2
rpoB 760970 c.1164G>C synonymous_variant 0.2
rpoB 760973 c.1167G>C synonymous_variant 0.3
rpoB 760982 c.1176G>C synonymous_variant 0.53
rpoB 760988 c.1182C>G synonymous_variant 0.47
rpoB 760991 c.1185G>C synonymous_variant 0.5
rpoB 761015 c.1209G>C synonymous_variant 0.69
rpoB 761027 c.1221A>G synonymous_variant 0.71
rpoB 761030 c.1224G>C synonymous_variant 0.69
rpoB 761036 c.1230G>C synonymous_variant 0.69
rpoB 761037 c.1231T>C synonymous_variant 0.69
rpoB 761051 c.1245G>T synonymous_variant 0.66
rpoB 761054 c.1248G>C synonymous_variant 0.67
rpoB 761060 c.1254C>G synonymous_variant 0.68
rpoB 761084 c.1278C>A synonymous_variant 0.67
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.67
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.69
rpoB 761102 c.1296A>G synonymous_variant 0.7
rpoB 761126 c.1320G>C synonymous_variant 0.69
rpoB 761132 c.1326G>T synonymous_variant 0.68
rpoB 761133 c.1327T>C synonymous_variant 0.68
rpoB 761150 c.1344A>C synonymous_variant 0.7
rpoB 761156 c.1350G>C synonymous_variant 0.65
rpoB 761165 c.1359G>C synonymous_variant 0.65
rpoB 761174 c.1368T>C synonymous_variant 0.64
rpoB 761177 c.1371G>C synonymous_variant 0.64
rpoB 761180 c.1374A>G synonymous_variant 0.66
rpoB 761183 c.1377T>C synonymous_variant 0.66
rpoB 761186 p.Glu460Asp missense_variant 0.66
rpoB 761192 c.1386C>G synonymous_variant 0.64
rpoB 761195 c.1389G>C synonymous_variant 0.56
rpoB 761207 c.1401C>T synonymous_variant 0.81
rpoB 761213 c.1407G>C synonymous_variant 0.81
rpoB 761219 c.1413G>C synonymous_variant 0.81
rpoB 761234 c.1428G>C synonymous_variant 0.79
rpoB 761249 c.1443A>G synonymous_variant 0.76
rpoB 761261 c.1455G>C synonymous_variant 0.71
rpoB 761262 p.Pro486Ser missense_variant 0.68
rpoB 761288 c.1482G>C synonymous_variant 0.71
rpoB 761289 p.Ser495Ala missense_variant 0.7
rpoB 761292 p.Val496Thr missense_variant 0.7
rpoB 761303 c.1497G>C synonymous_variant 0.68
rpoB 761304 p.Val500Ile missense_variant 0.68
rpoB 761327 c.1521A>G synonymous_variant 0.68
rpoB 761333 c.1527G>C synonymous_variant 0.66
rpoB 761345 c.1539G>C synonymous_variant 0.47
rpoB 761348 c.1542C>G synonymous_variant 0.45
rpoB 761579 c.1773G>C synonymous_variant 0.18
rpoB 761600 c.1794T>C synonymous_variant 0.18
rpoB 761603 c.1797C>G synonymous_variant 0.18
rpoB 761612 c.1806G>C synonymous_variant 0.18
rpoB 761974 p.His723Leu missense_variant 0.12
rpoB 761999 c.2193G>C synonymous_variant 0.14
rpoB 762194 c.2388G>C synonymous_variant 0.14
rpoB 762209 c.2403C>G synonymous_variant 0.16
rpoB 762212 c.2406G>C synonymous_variant 0.17
rpoB 762218 c.2412T>C synonymous_variant 0.25
rpoB 762233 c.2427G>T synonymous_variant 0.29
rpoB 762236 c.2430G>C synonymous_variant 0.29
rpoB 762245 c.2439G>C synonymous_variant 0.29
rpoB 762254 c.2448T>C synonymous_variant 0.27
rpoB 762266 c.2460T>C synonymous_variant 0.25
rpoB 762273 p.Ala823Ser missense_variant 0.25
rpoB 762293 c.2487T>C synonymous_variant 0.23
rpoB 762296 c.2490G>C synonymous_variant 0.23
rpoB 762299 c.2493G>C synonymous_variant 0.23
rpoB 762308 c.2502G>C synonymous_variant 0.24
rpoB 762317 c.2511A>G synonymous_variant 0.24
rpoB 762325 p.Lys840Thr missense_variant 0.23
rpoB 762336 p.Ile844Val missense_variant 0.15
rpoC 762827 c.-543G>C upstream_gene_variant 0.12
rpoC 762831 c.-539_-538delAGinsTC upstream_gene_variant 0.12
rpoB 762837 p.Glu1011Gln missense_variant 0.17
rpoB 762849 p.Tyr1015Asp missense_variant 0.29
rpoB 762858 p.Thr1018Ser missense_variant 0.35
rpoC 762863 c.-507T>G upstream_gene_variant 0.35
rpoB 762870 p.Met1022Gln missense_variant 0.35
rpoB 762879 p.Met1025Leu missense_variant 0.42
rpoC 762887 c.-483G>C upstream_gene_variant 0.44
rpoC 762929 c.-441G>T upstream_gene_variant 0.53
rpoC 762938 c.-432G>C upstream_gene_variant 0.5
rpoC 762980 c.-390T>C upstream_gene_variant 0.5
rpoC 762983 c.-387C>T upstream_gene_variant 0.52
rpoC 762989 c.-381G>C upstream_gene_variant 0.45
rpoC 762995 c.-375G>T upstream_gene_variant 0.39
rpoB 763005 p.Cys1067Val missense_variant 0.31
rpoC 763013 c.-357C>G upstream_gene_variant 0.28
rpoB 763014 p.Met1070Leu missense_variant 0.28
rpoB 763017 p.Gln1071Glu missense_variant 0.29
rpoC 763022 c.-348C>G upstream_gene_variant 0.28
rpoC 763028 c.-342T>C upstream_gene_variant 0.28
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763053 c.-317_-315delTTGinsCTC upstream_gene_variant 0.27
rpoB 763059 p.Ile1085Val missense_variant 0.27
rpoC 763070 c.-300T>C upstream_gene_variant 0.29
rpoB 763074 p.Thr1090Val missense_variant 0.29
rpoB 763077 p.Val1091His missense_variant 0.29
rpoC 763088 c.-282C>G upstream_gene_variant 0.31
rpoC 763103 c.-267G>C upstream_gene_variant 0.25
rpoC 763444 c.75T>C synonymous_variant 0.16
rpoC 763456 c.87A>G synonymous_variant 0.25
rpoC 763465 c.96G>A synonymous_variant 0.3
rpoC 763468 c.99G>C synonymous_variant 0.35
rpoC 763486 c.117T>C synonymous_variant 0.45
rpoC 763492 c.123G>C synonymous_variant 0.5
rpoC 763505 c.136C>T synonymous_variant 0.53
rpoC 763528 c.159G>T synonymous_variant 0.59
rpoC 763531 c.162G>C synonymous_variant 1.0
rpoC 763534 c.165T>C synonymous_variant 0.61
rpoC 763537 c.168C>G synonymous_variant 0.64
rpoC 763546 c.177A>G synonymous_variant 0.61
rpoC 763570 c.201G>C synonymous_variant 0.68
rpoC 763578 p.Phe70Tyr missense_variant 0.72
rpoC 763609 c.240C>G synonymous_variant 0.78
rpoC 763615 c.246G>C synonymous_variant 0.74
rpoC 763618 c.249C>G synonymous_variant 0.74
rpoC 763621 c.252C>T synonymous_variant 0.76
rpoC 763642 c.273G>C synonymous_variant 0.79
rpoC 763660 c.291T>C synonymous_variant 0.79
rpoC 763666 c.297G>T synonymous_variant 0.79
rpoC 763672 c.303C>G synonymous_variant 0.78
rpoC 763696 c.327T>C synonymous_variant 0.77
rpoC 763699 c.330G>T synonymous_variant 0.77
rpoC 763708 c.339G>C synonymous_variant 0.74
rpoC 763709 c.340C>T synonymous_variant 0.74
rpoC 763714 c.345G>C synonymous_variant 0.72
rpoC 763717 c.348T>C synonymous_variant 0.72
rpoC 763729 c.360G>C synonymous_variant 0.71
rpoC 763732 c.363C>G synonymous_variant 0.7
rpoC 763735 c.366G>C synonymous_variant 0.69
rpoC 763744 c.375G>C synonymous_variant 0.64
rpoC 763751 p.Ile128Val missense_variant 0.58
rpoC 763765 c.396T>G synonymous_variant 0.55
rpoC 763768 c.399C>G synonymous_variant 0.52
rpoC 763772 p.Val135Met missense_variant 0.45
rpoC 763780 c.411C>G synonymous_variant 0.31
rpoC 763783 c.414G>C synonymous_variant 0.23
rpoC 763786 c.417C>G synonymous_variant 0.23
rpoC 763884 p.Ala172Val missense_variant 1.0
rpoC 763886 c.517C>A synonymous_variant 1.0
rpoC 764286 p.Gly306Asp missense_variant 0.36
rpoC 764297 p.Met310Leu missense_variant 0.38
rpoC 764308 c.939G>C synonymous_variant 0.36
rpoC 764311 c.942C>G synonymous_variant 0.4
rpoC 764320 c.951C>T synonymous_variant 0.4
rpoC 764347 c.978G>C synonymous_variant 0.57
rpoC 764359 c.990C>G synonymous_variant 0.61
rpoC 764365 c.996C>T synonymous_variant 0.65
rpoC 764377 c.1008C>G synonymous_variant 0.68
rpoC 764380 c.1011G>C synonymous_variant 0.69
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.71
rpoC 764398 c.1029G>C synonymous_variant 0.74
rpoC 764404 c.1035C>T synonymous_variant 0.77
rpoC 764405 c.1036A>C synonymous_variant 0.79
rpoC 764428 c.1059G>C synonymous_variant 0.76
rpoC 764434 c.1065A>G synonymous_variant 0.72
rpoC 764435 c.1066_1068delAGGinsCGT synonymous_variant 0.71
rpoC 764441 p.Ile358Leu missense_variant 0.7
rpoC 764446 c.1077T>C synonymous_variant 0.7
rpoC 764449 c.1080G>C synonymous_variant 0.7
rpoC 764455 c.1086G>C synonymous_variant 0.71
rpoC 764458 c.1089G>C synonymous_variant 0.71
rpoC 764461 c.1092A>G synonymous_variant 0.72
rpoC 764470 c.1101C>G synonymous_variant 0.77
rpoC 764485 c.1116G>C synonymous_variant 0.78
rpoC 764497 c.1128A>G synonymous_variant 0.79
rpoC 764498 p.Ser377Ala missense_variant 0.81
rpoC 764507 p.Ala380Ser missense_variant 0.84
rpoC 764521 c.1152T>C synonymous_variant 0.75
rpoC 764524 c.1155C>T synonymous_variant 0.74
rpoC 764536 c.1167G>T synonymous_variant 0.74
rpoC 764545 c.1176C>G synonymous_variant 0.8
rpoC 764548 c.1179G>T synonymous_variant 0.79
rpoC 764561 p.Pro398Ala missense_variant 0.79
rpoC 764566 c.1197C>G synonymous_variant 0.79
rpoC 764572 c.1203G>C synonymous_variant 0.79
rpoC 764575 c.1206T>G synonymous_variant 0.79
rpoC 764581 c.1212T>C synonymous_variant 0.79
rpoC 764582 p.Leu405Met missense_variant 0.81
rpoC 764602 c.1233C>A synonymous_variant 0.82
rpoC 764605 c.1236G>C synonymous_variant 0.82
rpoC 764611 c.1242G>C synonymous_variant 0.83
rpoC 764623 c.1254C>G synonymous_variant 0.82
rpoC 764632 c.1263T>C synonymous_variant 0.8
rpoC 764635 c.1266C>G synonymous_variant 0.79
rpoC 764644 c.1275G>C synonymous_variant 0.72
rpoC 764647 c.1278C>T synonymous_variant 0.71
rpoC 764650 c.1281G>T synonymous_variant 0.71
rpoC 764653 c.1284G>C synonymous_variant 0.72
rpoC 764656 c.1287C>G synonymous_variant 0.73
rpoC 764665 c.1296C>G synonymous_variant 0.78
rpoC 764668 c.1299C>T synonymous_variant 0.77
rpoC 764677 c.1308C>G synonymous_variant 0.78
rpoC 764706 p.Leu446Gln missense_variant 0.76
rpoC 764746 c.1377G>C synonymous_variant 0.8
rpoC 764758 c.1389C>G synonymous_variant 0.78
rpoC 764764 c.1395T>C synonymous_variant 0.77
rpoC 764767 c.1398G>T synonymous_variant 0.77
rpoC 764770 c.1401G>A synonymous_variant 0.76
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.78
rpoC 764804 p.Gln479Tyr missense_variant 0.77
rpoC 764809 c.1440C>T synonymous_variant 0.76
rpoC 764815 c.1446A>G synonymous_variant 0.75
rpoC 764824 c.1455T>C synonymous_variant 0.74
rpoC 764830 c.1461C>G synonymous_variant 0.7
rpoC 764843 p.Ala492Thr missense_variant 0.68
rpoC 764858 c.1489T>C synonymous_variant 0.66
rpoC 764869 c.1500C>T synonymous_variant 0.54
rpoC 764872 c.1503A>G synonymous_variant 0.56
rpoC 764887 c.1518G>T synonymous_variant 0.44
rpoC 764888 c.1519T>C synonymous_variant 0.44
rpoC 764893 c.1524T>C synonymous_variant 0.42
rpoC 764902 c.1533C>T synonymous_variant 0.38
rpoC 764911 c.1542A>G synonymous_variant 0.33
rpoC 764912 p.Met515Gln missense_variant 0.33
rpoC 764917 c.1548G>C synonymous_variant 0.33
rpoC 764923 c.1554A>G synonymous_variant 0.34
rpoC 764935 c.1566T>C synonymous_variant 0.28
rpoC 764948 c.1579_1581delTTGinsCTC synonymous_variant 0.28
rpoC 764956 c.1587T>C synonymous_variant 0.26
rpoC 764958 p.Glu530Gly missense_variant 0.26
rpoC 764968 c.1599T>C synonymous_variant 0.28
rpoC 764971 c.1602C>G synonymous_variant 0.28
rpoC 764995 c.1626C>G synonymous_variant 0.22
rpoC 764998 c.1629G>T synonymous_variant 0.19
rpoC 765934 c.2565C>T synonymous_variant 0.15
rpoC 765979 c.2610C>G synonymous_variant 0.13
rpoC 766009 c.2640G>C synonymous_variant 0.14
rpoC 766012 c.2643C>G synonymous_variant 0.14
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303016 p.Val29Gly missense_variant 0.41
Rv1258c 1406312 c.1029T>C synonymous_variant 1.0
embR 1417019 p.Cys110Tyr missense_variant 1.0
atpE 1460907 c.-138T>C upstream_gene_variant 0.92
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.89
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.89
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.89
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.89
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.93
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.93
rrs 1472225 n.380C>G non_coding_transcript_exon_variant 0.94
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.92
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.81
rrs 1472289 n.444T>C non_coding_transcript_exon_variant 0.82
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.82
rrs 1472293 n.448C>A non_coding_transcript_exon_variant 0.83
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.83
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.83
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.85
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.85
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.83
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.83
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.71
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.69
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.38
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.5
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.47
rrs 1472496 n.651T>A non_coding_transcript_exon_variant 0.47
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.57
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.83
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.81
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.8
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.81
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.82
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.89
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.9
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.89
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.89
rrs 1472674 n.829T>A non_coding_transcript_exon_variant 0.89
rrs 1472675 n.830T>A non_coding_transcript_exon_variant 0.89
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.89
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.9
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.92
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.88
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.85
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.85
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.83
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.82
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.79
rrs 1472845 n.1000G>C non_coding_transcript_exon_variant 0.77
rrs 1472846 n.1001C>G non_coding_transcript_exon_variant 0.77
rrs 1472848 n.1003T>G non_coding_transcript_exon_variant 0.77
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.77
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.8
rrs 1472859 n.1014G>T non_coding_transcript_exon_variant 0.8
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.8
rrs 1472863 n.1020_1021dupCC non_coding_transcript_exon_variant 0.8
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.87
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.91
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.94
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.96
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.95
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.96
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.97
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.96
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.97
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.97
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.97
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.98
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.96
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.96
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.97
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.97
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.97
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.97
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.97
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.97
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.98
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.98
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.98
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.98
rrs 1473147 n.1302G>T non_coding_transcript_exon_variant 0.97
rrs 1473164 n.1319C>A non_coding_transcript_exon_variant 0.97
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.92
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.92
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.9
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.88
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.88
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.82
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.81
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.75
rrl 1474124 n.467G>C non_coding_transcript_exon_variant 0.92
rrl 1474125 n.468C>G non_coding_transcript_exon_variant 0.92
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.94
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.94
rrl 1474141 n.484G>C non_coding_transcript_exon_variant 0.94
rrl 1474142 n.485C>G non_coding_transcript_exon_variant 0.94
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.94
rrl 1474155 n.498G>A non_coding_transcript_exon_variant 0.94
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.89
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.94
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.94
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.94
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.94
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.95
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.95
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 1.0
rrl 1474275 n.618T>G non_coding_transcript_exon_variant 1.0
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 1.0
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 1.0
rrl 1474353 n.696A>T non_coding_transcript_exon_variant 1.0
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 1.0
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 1.0
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 1.0
rrl 1474365 n.708G>A non_coding_transcript_exon_variant 0.73
rrl 1474384 n.727C>T non_coding_transcript_exon_variant 0.67
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.62
rrl 1474450 n.793T>A non_coding_transcript_exon_variant 0.7
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.71
rrl 1474467 n.810A>G non_coding_transcript_exon_variant 0.44
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.89
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.91
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.91
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.95
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.95
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.95
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.97
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 1.0
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 1.0
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.94
rrl 1474633 n.977_981delTCACC non_coding_transcript_exon_variant 1.0
rrl 1474640 n.983_984insTTGCT non_coding_transcript_exon_variant 0.94
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.88
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.92
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.89
rrl 1474708 n.1051_1052insA non_coding_transcript_exon_variant 0.81
rrl 1474711 n.1054G>C non_coding_transcript_exon_variant 0.81
rrl 1474712 n.1055G>A non_coding_transcript_exon_variant 0.81
rrl 1474713 n.1056T>A non_coding_transcript_exon_variant 0.81
rrl 1474716 n.1059A>T non_coding_transcript_exon_variant 0.81
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 0.81
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.86
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.86
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.76
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.76
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.76
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.82
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.82
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.82
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.82
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.83
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.82
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.83
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.81
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.77
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.82
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.79
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.79
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.75
rrl 1474945 n.1288C>T non_coding_transcript_exon_variant 0.5
rrl 1475515 n.1858G>A non_coding_transcript_exon_variant 0.5
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.5
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.5
rrl 1475673 n.2016T>C non_coding_transcript_exon_variant 0.55
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.89
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.94
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.94
rrl 1475757 n.2100_2101insG non_coding_transcript_exon_variant 0.95
rrl 1475760 n.2105_2106delGC non_coding_transcript_exon_variant 0.95
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.95
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.95
rrl 1475769 n.2112_2113insC non_coding_transcript_exon_variant 0.95
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.85
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.8
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.82
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.85
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.85
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.83
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.82
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.81
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.78
rrl 1475963 n.2306G>A non_coding_transcript_exon_variant 0.73
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.71
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.69
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.68
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.68
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.72
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.69
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.69
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.65
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.38
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.38
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.25
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.25
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.5
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.5
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.57
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.57
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.53
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.53
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.53
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.53
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.53
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.47
rrl 1476308 n.2651G>T non_coding_transcript_exon_variant 0.56
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.56
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.5
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.76
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.82
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.89
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.88
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.88
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.87
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.85
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.8
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.69
rrl 1476519 n.2862C>T non_coding_transcript_exon_variant 0.55
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.44
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.44
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.4
rrl 1476534 n.2877A>T non_coding_transcript_exon_variant 0.4
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.4
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.4
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.36
inhA 1674162 c.-40C>T upstream_gene_variant 1.0
rpsA 1833832 c.291G>A synonymous_variant 0.12
rpsA 1833862 c.321G>C synonymous_variant 0.14
rpsA 1833874 c.333T>C synonymous_variant 0.13
rpsA 1833928 c.387G>C synonymous_variant 0.18
rpsA 1833952 c.411C>T synonymous_variant 0.68
rpsA 1833955 c.414G>C synonymous_variant 0.68
rpsA 1833961 c.420C>G synonymous_variant 0.7
rpsA 1833970 c.429G>C synonymous_variant 0.76
rpsA 1833979 c.438T>C synonymous_variant 0.78
rpsA 1833988 c.447C>G synonymous_variant 0.74
rpsA 1833994 c.453G>C synonymous_variant 0.76
rpsA 1833997 c.456G>C synonymous_variant 0.76
rpsA 1834009 c.468C>T synonymous_variant 0.74
rpsA 1834012 c.471G>C synonymous_variant 0.74
rpsA 1834015 c.474G>C synonymous_variant 0.76
rpsA 1834024 c.483G>C synonymous_variant 0.74
rpsA 1834025 p.Gln162Ala missense_variant 0.74
rpsA 1834030 c.489C>G synonymous_variant 0.72
rpsA 1834040 p.Lys167Gln missense_variant 0.72
rpsA 1834043 p.Glu168Gln missense_variant 0.72
rpsA 1834046 p.Ile169Leu missense_variant 0.7
rpsA 1834081 c.540C>T synonymous_variant 0.69
rpsA 1834102 c.561T>C synonymous_variant 0.5
rpsA 1834105 c.564C>T synonymous_variant 0.5
rpsA 1834108 c.567C>A synonymous_variant 0.5
rpsA 1834114 c.573G>C synonymous_variant 0.39
rpsA 1834185 p.Val215Ala missense_variant 0.15
rpsA 1834210 c.669C>T synonymous_variant 0.5
rpsA 1834219 c.678C>G synonymous_variant 0.5
rpsA 1834222 c.681T>C synonymous_variant 0.53
rpsA 1834225 c.684C>G synonymous_variant 0.53
rpsA 1834228 c.687C>T synonymous_variant 0.53
rpsA 1834231 c.690T>C synonymous_variant 0.53
rpsA 1834240 c.699T>C synonymous_variant 0.53
rpsA 1834243 c.702G>C synonymous_variant 0.53
rpsA 1834249 c.708T>C synonymous_variant 0.53
rpsA 1834261 c.720A>G synonymous_variant 0.55
rpsA 1834264 c.723G>C synonymous_variant 0.55
rpsA 1834285 c.744G>C synonymous_variant 0.5
rpsA 1834294 c.753G>C synonymous_variant 0.48
rpsA 1834298 p.Gln253Glu missense_variant 0.5
rpsA 1834303 c.762T>C synonymous_variant 0.42
rpsA 1834307 p.Asp256Gln missense_variant 0.44
rpsA 1834312 c.771G>A synonymous_variant 0.44
rpsA 1834321 c.780C>G synonymous_variant 0.42
rpsA 1834327 c.786G>C synonymous_variant 0.42
rpsA 1834330 c.789C>G synonymous_variant 0.42
rpsA 1834336 c.795C>G synonymous_variant 0.4
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918096 p.Thr53Ala missense_variant 0.22
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2222252 p.Val305Ile missense_variant 0.15
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0
Rv1979c 2222352 c.813A>G synonymous_variant 0.14
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
kasA 2519048 p.Gly312Ser missense_variant 0.93
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0
ahpC 2726193 c.1A>G start_lost 0.18
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339108 c.-9_-7delGAT upstream_gene_variant 0.18
fbiD 3339417 c.300A>G synonymous_variant 1.0
fbiD 3339506 p.Ser130Leu missense_variant 0.33
Rv3083 3448714 p.Asp71His missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474597 c.591C>A synonymous_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 1.0
whiB7 3568488 c.191delG frameshift_variant 1.0
fbiB 3640557 c.-978T>C upstream_gene_variant 1.0
clpC1 4039685 c.1020C>T synonymous_variant 0.13
clpC1 4039714 p.Tyr331His missense_variant 0.56
clpC1 4039724 c.981A>G synonymous_variant 0.57
clpC1 4039730 c.975C>G synonymous_variant 0.6
clpC1 4039733 c.972G>C synonymous_variant 0.61
clpC1 4039748 c.957G>C synonymous_variant 0.67
clpC1 4039751 c.954A>G synonymous_variant 0.67
clpC1 4039757 c.948A>G synonymous_variant 0.67
clpC1 4039766 c.939T>C synonymous_variant 0.76
clpC1 4039769 c.936C>G synonymous_variant 0.76
clpC1 4039773 p.Lys311Met missense_variant 0.78
clpC1 4039775 c.930G>C synonymous_variant 0.78
clpC1 4039778 c.927A>G synonymous_variant 0.79
clpC1 4039781 c.924G>C synonymous_variant 0.82
clpC1 4039817 c.888A>T synonymous_variant 0.87
clpC1 4039820 c.885T>C synonymous_variant 0.87
clpC1 4039826 c.879C>G synonymous_variant 0.84
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.82
clpC1 4039838 p.Leu289Ile missense_variant 0.84
clpC1 4039850 c.855T>C synonymous_variant 0.79
clpC1 4039865 c.840T>G synonymous_variant 0.72
clpC1 4039875 p.Asn277Arg missense_variant 0.68
clpC1 4039898 c.807C>G synonymous_variant 0.61
clpC1 4039904 c.801A>G synonymous_variant 0.62
clpC1 4039928 c.775_777delAGCinsTCT synonymous_variant 0.65
clpC1 4039943 c.762G>C synonymous_variant 0.67
clpC1 4039946 c.759A>C synonymous_variant 0.64
clpC1 4039949 c.756G>C synonymous_variant 0.64
clpC1 4039952 c.753T>C synonymous_variant 0.64
clpC1 4039979 c.726C>G synonymous_variant 0.68
clpC1 4039982 c.723G>C synonymous_variant 0.67
clpC1 4039988 c.717C>G synonymous_variant 0.67
clpC1 4039991 c.714G>C synonymous_variant 0.67
clpC1 4039994 p.Glu237Asp missense_variant 0.73
clpC1 4039997 c.708C>A synonymous_variant 0.73
clpC1 4040001 p.His235Arg missense_variant 0.73
clpC1 4040003 c.702G>C synonymous_variant 0.75
clpC1 4040018 c.687G>C synonymous_variant 0.75
clpC1 4040021 c.684A>C synonymous_variant 0.75
clpC1 4040024 c.681A>G synonymous_variant 0.73
clpC1 4040027 c.678C>G synonymous_variant 0.73
clpC1 4040030 c.675C>G synonymous_variant 0.73
clpC1 4040033 c.672G>C synonymous_variant 0.73
clpC1 4040045 c.660C>G synonymous_variant 0.79
clpC1 4040069 c.636G>C synonymous_variant 0.65
clpC1 4040087 c.618G>A synonymous_variant 0.5
clpC1 4040090 c.615T>G synonymous_variant 0.5
clpC1 4040105 c.600C>G synonymous_variant 0.23
clpC1 4040108 c.597G>C synonymous_variant 0.17
clpC1 4040517 p.Val63Ala missense_variant 1.0
clpC1 4040657 c.48T>C synonymous_variant 0.19
clpC1 4040663 c.42C>G synonymous_variant 0.17
clpC1 4040669 c.36C>G synonymous_variant 0.18
clpC1 4040674 c.31A>C synonymous_variant 0.19
clpC1 4040690 c.15T>C synonymous_variant 0.17
clpC1 4040693 c.12A>C synonymous_variant 0.17
embC 4240671 p.Thr270Ile missense_variant 1.0
embC 4241042 p.Asn394Asp missense_variant 0.83
embC 4241087 p.Thr409Ala missense_variant 0.18
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243580 c.348G>A synonymous_variant 1.0
embA 4244420 c.1188G>C synonymous_variant 1.0
embA 4245969 p.Pro913Ser missense_variant 1.0
embB 4247578 c.1065G>A synonymous_variant 1.0
embB 4247646 p.Glu378Ala missense_variant 1.0
embB 4248548 p.Ala679Thr missense_variant 0.12
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
ubiA 4269864 c.-32delG upstream_gene_variant 1.0
whiB6 4338361 p.Arg54Gln missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407873 c.330G>T synonymous_variant 1.0