Run ID: SRR17832802
Sample name:
Date: 2024-10-04T05:54:30.282951
Number of reads: 2643467
Percentage reads mapped: 74.74
Median coverage: 64.0
Strain: lineage3
Spoligotype:
Drug-resistance: HR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage3 | East-African-Indian | RD750 | 0.99 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | katG | p.Ser315Thr | Assoc w R | High-level resistance |
ethambutol | ||||
pyrazinamide | ||||
streptomycin | gid | p.Cys52* | Assoc w R | |
fluoroquinolones | ||||
moxifloxacin | gyrA | p.Asp94Asn | Assoc w R | High-level resistance |
ofloxacin | ||||
levofloxacin | gyrA | p.Asp94Asn | Assoc w R | |
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
gyrA | 7581 | p.Asp94Asn | missense_variant | 0.65 | levofloxacin | Assoc w R | |
moxifloxacin | Assoc w R | High-level resistance | |||||
katG | 2155168 | p.Ser315Thr | missense_variant | 0.98 | isoniazid | Assoc w R | High-level resistance |
gid | 4408047 | p.Cys52* | stop_gained | 1.0 | streptomycin | Assoc w R |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrB | 6190 | c.951A>G | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7433 | c.132G>C | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7451 | c.150C>G | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7457 | c.156T>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7469 | c.168C>G | synonymous_variant | 0.14 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7475 | c.174A>G | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7480 | p.Phe60Tyr | missense_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7484 | c.183T>C | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7490 | c.189C>G | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7502 | c.201C>T | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7526 | c.225G>T | synonymous_variant | 0.28 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7532 | c.231T>C | synonymous_variant | 0.28 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7541 | c.240C>G | synonymous_variant | 0.3 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7547 | c.246C>T | synonymous_variant | 0.34 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7601 | c.300C>G | synonymous_variant | 0.28 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7626 | c.325C>T | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7631 | c.330G>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7643 | c.342C>T | synonymous_variant | 0.21 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 7646 | c.345C>T | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7655 | c.354G>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7658 | c.357A>G | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7661 | c.360C>T | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7664 | c.363T>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7670 | c.369A>G | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7673 | c.372G>A | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7676 | c.375G>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7679 | c.378G>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7742 | c.441G>A | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7769 | c.468C>T | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7832 | c.531G>T | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7835 | c.534A>G | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8555 | c.1254G>C | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8561 | c.1260A>C | synonymous_variant | 0.16 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8678 | c.1377G>A | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R | |||||
Rv0565c | 657081 | c.390G>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
nusG | 734478 | c.225C>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 759746 | c.-61C>T | upstream_gene_variant | 1.0 | rifampicin | Not assoc w R |
rpoB | 760181 | c.375T>A | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760184 | c.378A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760196 | c.390C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760235 | c.429T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760274 | c.468G>A | synonymous_variant | 0.21 | rifampicin | |
rpoB | 760295 | c.489C>T | synonymous_variant | 0.18 | rifampicin | |
rpoB | 760307 | c.501T>C | synonymous_variant | 0.19 | rifampicin | |
rpoB | 760310 | c.504G>C | synonymous_variant | 0.19 | rifampicin | |
rpoB | 760328 | c.522G>C | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760381 | p.Thr192Met | missense_variant | 0.15 | rifampicin | |
rpoB | 760591 | p.Val262Ala | missense_variant | 0.15 | rifampicin | |
rpoB | 760601 | c.795C>T | synonymous_variant | 0.16 | rifampicin | |
rpoB | 760674 | c.868T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760679 | c.873A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760683 | c.877T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760769 | c.963C>G | synonymous_variant | 0.13 | rifampicin | |
rpoB | 760937 | c.1131G>A | synonymous_variant | 0.18 | rifampicin | |
rpoB | 760946 | c.1140A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760973 | c.1167G>C | synonymous_variant | 0.22 | rifampicin | |
rpoB | 760982 | c.1176G>T | synonymous_variant | 0.25 | rifampicin | |
rpoB | 760985 | c.1179G>T | synonymous_variant | 0.25 | rifampicin | |
rpoB | 760991 | c.1185G>T | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 761006 | c.1200C>T | synonymous_variant | 0.27 | rifampicin | |
rpoB | 761015 | c.1209G>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 761021 | c.1215G>C | synonymous_variant | 0.25 | rifampicin | |
rpoB | 761027 | c.1221A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 761036 | c.1230G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 761037 | c.1231T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 761051 | c.1245G>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 761057 | c.1251G>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 761060 | c.1254C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 761063 | c.1257C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 761189 | c.1383T>G | synonymous_variant | 0.15 | rifampicin | |
rpoB | 761192 | c.1386C>G | synonymous_variant | 0.15 | rifampicin | |
rpoB | 761195 | c.1389G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761198 | c.1392G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761240 | c.1434C>T | synonymous_variant | 0.17 | rifampicin | |
rpoB | 761249 | c.1443A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761255 | c.1449T>C | synonymous_variant | 0.17 | rifampicin | |
rpoB | 761261 | c.1455G>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761282 | c.1476C>G | synonymous_variant | 0.14 | rifampicin | |
rpoB | 761531 | c.1725C>G | synonymous_variant | 0.15 | rifampicin | |
rpoB | 761537 | c.1731C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761558 | c.1752C>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 761570 | c.1764T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 761573 | c.1767C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 761579 | c.1773G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 761606 | c.1800C>G | synonymous_variant | 0.17 | rifampicin | |
rpoB | 761612 | c.1806G>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761750 | c.1944G>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 761765 | c.1959T>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 761772 | p.His656Ala | missense_variant | 0.17 | rifampicin | |
rpoB | 761778 | p.Asn658Asp | missense_variant | 0.17 | rifampicin | |
rpoB | 761828 | c.2022C>T | synonymous_variant | 0.15 | rifampicin | |
rpoB | 761834 | c.2028T>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 761837 | c.2031C>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761873 | c.2067A>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 761930 | c.2124G>C | synonymous_variant | 0.21 | rifampicin | |
rpoB | 761954 | c.2148C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 762008 | c.2202C>G | synonymous_variant | 0.19 | rifampicin | |
rpoB | 762014 | c.2208C>T | synonymous_variant | 0.18 | rifampicin | |
rpoB | 762047 | c.2241G>A | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 762053 | c.2247T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 762062 | c.2256T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 762065 | c.2259T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 762083 | c.2277T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 762086 | c.2280G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 762101 | c.2295C>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 762114 | p.Ile770Val | missense_variant | 0.25 | rifampicin | Uncertain significance |
rpoB | 762131 | c.2325C>G | synonymous_variant | 0.22 | rifampicin | |
rpoB | 762134 | c.2328C>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 762143 | c.2337T>C | synonymous_variant | 0.2 | rifampicin | |
rpoB | 762167 | c.2361T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 762185 | c.2379G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 762233 | c.2427G>T | synonymous_variant | 0.25 | rifampicin | |
rpoB | 762254 | c.2448T>G | synonymous_variant | 0.26 | rifampicin | |
rpoB | 762257 | c.2451C>G | synonymous_variant | 0.26 | rifampicin | |
rpoB | 762266 | c.2460T>C | synonymous_variant | 0.25 | rifampicin | |
rpoB | 762281 | c.2475G>A | synonymous_variant | 0.26 | rifampicin | |
rpoB | 762284 | c.2478G>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 762293 | c.2487T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 762317 | c.2511A>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 762338 | c.2532T>C | synonymous_variant | 0.24 | rifampicin | |
rpoB | 762341 | c.2535G>C | synonymous_variant | 0.25 | rifampicin | |
rpoB | 762347 | c.2541T>C | synonymous_variant | 0.26 | rifampicin | |
rpoB | 762369 | c.2563T>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 762395 | c.-975G>C | upstream_gene_variant | 0.13 | rifampicin | |
rpoB | 762434 | c.2628T>G | synonymous_variant | 0.91 | rifampicin | Not assoc w R |
rpoB | 763031 | c.3225T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
rpoC | 763402 | c.33C>T | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 763409 | c.40_42delCTTinsTTG | synonymous_variant | 0.21 | rifampicin | |
rpoC | 763414 | c.45T>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 763441 | c.72C>T | synonymous_variant | 0.21 | rifampicin | |
rpoC | 763444 | c.75T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 763456 | c.87A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 763486 | c.117T>G | synonymous_variant | 0.2 | rifampicin | |
rpoC | 763528 | c.159G>A | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 763618 | c.249C>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763636 | c.267T>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763872 | p.Gly168Ala | missense_variant | 0.2 | rifampicin | |
rpoC | 763876 | p.Glu169Asp | missense_variant | 0.2 | rifampicin | |
rpoC | 763879 | c.510A>G | synonymous_variant | 0.22 | rifampicin | |
rpoC | 763888 | c.519G>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 763891 | c.522G>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 763894 | c.525A>G | synonymous_variant | 0.21 | rifampicin | |
rpoC | 763936 | c.567C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763939 | c.570G>A | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763951 | c.582G>A | synonymous_variant | 0.17 | rifampicin | |
rpoC | 763963 | c.594C>G | synonymous_variant | 0.15 | rifampicin | |
rpoC | 763967 | p.Gly200Ser | missense_variant | 0.17 | rifampicin | |
rpoC | 763972 | c.603C>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763987 | c.618C>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763996 | c.627T>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764005 | c.636G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764011 | c.642T>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764024 | c.655T>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764040 | p.Ser224Thr | missense_variant | 0.16 | rifampicin | |
rpoC | 764044 | c.675T>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764059 | c.690G>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764083 | c.714A>G | synonymous_variant | 0.15 | rifampicin | |
rpoC | 764098 | c.729A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764101 | c.732C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764159 | c.790C>T | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764215 | c.846A>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764218 | c.849C>T | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764242 | c.873C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764428 | c.1059G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764431 | c.1062G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764434 | c.1065A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764446 | c.1077T>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764449 | c.1080G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764452 | c.1083T>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764458 | c.1089G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764461 | c.1092A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764497 | c.1128A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764503 | c.1134G>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764521 | c.1152T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764527 | c.1158C>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764536 | c.1167G>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764539 | c.1170C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764554 | c.1185C>T | synonymous_variant | 0.2 | rifampicin | |
rpoC | 764575 | c.1206T>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764578 | c.1209C>G | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764593 | c.1224C>T | synonymous_variant | 0.22 | rifampicin | |
rpoC | 764605 | c.1236G>A | synonymous_variant | 0.24 | rifampicin | |
rpoC | 764626 | c.1257C>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764647 | c.1278C>T | synonymous_variant | 0.25 | rifampicin | |
rpoC | 764650 | c.1281G>T | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764668 | c.1299C>T | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 764686 | c.1317C>T | synonymous_variant | 0.33 | rifampicin | |
rpoC | 764696 | c.1327C>T | synonymous_variant | 0.3 | rifampicin | |
rpoC | 764746 | c.1377G>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764858 | c.1489T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764887 | c.1518G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764888 | c.1519_1521delTTGinsCTC | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764896 | c.1527C>T | synonymous_variant | 0.23 | rifampicin | |
rpoC | 764902 | c.1533C>T | synonymous_variant | 0.22 | rifampicin | |
rpoC | 764911 | c.1542A>G | synonymous_variant | 0.22 | rifampicin | |
rpoC | 764923 | c.1554A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764932 | c.1563C>G | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764948 | c.1579T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 764968 | c.1599T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765319 | c.1950A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 765328 | p.His653Gln | missense_variant | 0.17 | rifampicin | Uncertain significance |
rpoC | 765330 | p.Ser654Asn | missense_variant | 0.16 | rifampicin | Uncertain significance |
rpoC | 765334 | c.1965C>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765343 | c.1974G>A | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765352 | c.1983G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765406 | c.2037G>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765409 | c.2040T>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 765412 | c.2043T>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 765421 | c.2052C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765452 | p.Ala695Ser | missense_variant | 0.16 | rifampicin | |
rpoC | 765499 | c.2130C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 765508 | c.2139C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765517 | c.2148C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765541 | c.2172C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765728 | p.Gln787Lys | missense_variant | 0.17 | rifampicin | |
rpoC | 765734 | c.2365T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 765739 | c.2370G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765752 | p.Asp795Ser | missense_variant | 0.2 | rifampicin | |
rpoC | 765772 | c.2403C>G | synonymous_variant | 0.23 | rifampicin | |
rpoC | 765784 | c.2415C>G | synonymous_variant | 0.22 | rifampicin | |
rpoC | 765790 | c.2421C>T | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 765793 | c.2424C>G | synonymous_variant | 0.22 | rifampicin | |
rpoC | 765796 | c.2427C>T | synonymous_variant | 0.22 | rifampicin | |
rpoC | 765811 | c.2442T>A | synonymous_variant | 0.17 | rifampicin | |
rpoC | 765814 | c.2445A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 766381 | c.3012C>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766384 | c.3015A>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766393 | c.3024C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766402 | c.3033C>G | synonymous_variant | 0.21 | rifampicin | |
rpoC | 766408 | c.3039C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 766426 | c.3057C>T | synonymous_variant | 0.26 | rifampicin | |
rpoC | 766456 | c.3087C>G | synonymous_variant | 0.34 | rifampicin | |
rpoC | 766486 | c.3117A>G | synonymous_variant | 0.35 | rifampicin | |
rpoC | 766492 | c.3123T>C | synonymous_variant | 0.35 | rifampicin | |
rpoC | 766522 | c.3153C>G | synonymous_variant | 0.38 | rifampicin | |
rpoC | 766528 | c.3159T>C | synonymous_variant | 0.33 | rifampicin | |
rpoC | 766530 | p.Arg1054Gln | missense_variant | 0.33 | rifampicin | |
rpoC | 766549 | c.3180G>C | synonymous_variant | 0.29 | rifampicin | |
rpoC | 766573 | c.3204T>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766585 | c.3216T>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766594 | c.3225G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766607 | p.Ile1080Leu | missense_variant | 0.19 | rifampicin | |
rpoC | 766672 | c.3303T>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766700 | c.3331C>T | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766726 | c.3357T>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766733 | c.3364C>T | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766738 | c.3369G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766741 | c.3372G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766750 | c.3381C>G | synonymous_variant | 0.26 | rifampicin | |
rpoC | 766765 | c.3396A>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 766774 | c.3405T>C | synonymous_variant | 0.26 | rifampicin | |
rpoC | 766798 | c.3429C>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 766801 | c.3432C>G | synonymous_variant | 0.28 | rifampicin | |
rpoC | 766804 | c.3435A>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 766843 | c.3474T>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 766864 | c.3495G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766876 | c.3507C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 766883 | p.Ser1172Ala | missense_variant | 0.26 | rifampicin | Uncertain significance |
rpoC | 766894 | c.3525T>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766895 | c.3526T>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 766900 | c.3531T>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 766903 | c.3534C>T | synonymous_variant | 0.22 | rifampicin | |
rpoC | 766918 | c.3549C>T | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 766933 | c.3564A>G | synonymous_variant | 0.26 | rifampicin | |
rpoC | 766945 | c.3576A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 766963 | c.3594T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 766996 | c.3627C>G | synonymous_variant | 0.22 | rifampicin | |
rpoC | 767002 | c.3633G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 767014 | c.3645G>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 767033 | c.3664_3666delTCGinsAGT | synonymous_variant | 0.19 | rifampicin | |
rpoC | 767149 | c.3780C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 767158 | c.3789T>A | synonymous_variant | 0.15 | rifampicin | |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
mmpL5 | 775981 | p.Leu834Met | missense_variant | 0.17 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 776009 | c.2472A>G | synonymous_variant | 0.17 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
mmpL5 | 777820 | c.661C>T | synonymous_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R - Interim | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781766 | c.207C>T | synonymous_variant | 0.17 | streptomycin | Not assoc w R - Interim |
rpsL | 781772 | c.213C>G | synonymous_variant | 0.16 | streptomycin | |
rpsL | 781793 | c.234G>C | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781808 | c.249C>T | synonymous_variant | 0.15 | streptomycin | |
rpsL | 781832 | c.273T>G | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781835 | c.276T>C | synonymous_variant | 0.15 | streptomycin | Not assoc w R - Interim |
rpsL | 781850 | c.291C>A | synonymous_variant | 0.16 | streptomycin | |
rpsL | 781859 | c.300T>G | synonymous_variant | 0.18 | streptomycin | |
rplC | 800612 | c.-197A>G | upstream_gene_variant | 0.16 | linezolid | |
rplC | 800618 | c.-191T>C | upstream_gene_variant | 0.16 | linezolid | |
rplC | 800621 | c.-188G>A | upstream_gene_variant | 0.16 | linezolid | |
rplC | 800627 | c.-182C>T | upstream_gene_variant | 0.18 | linezolid | |
rplC | 800648 | c.-161A>G | upstream_gene_variant | 0.19 | linezolid | |
rplC | 800654 | c.-155T>C | upstream_gene_variant | 0.2 | linezolid | |
rplC | 800693 | c.-116A>G | upstream_gene_variant | 0.21 | linezolid | |
rplC | 800703 | c.-106T>C | upstream_gene_variant | 0.23 | linezolid | |
rplC | 800714 | c.-95C>T | upstream_gene_variant | 0.2 | linezolid | |
rplC | 800715 | c.-94A>C | upstream_gene_variant | 0.2 | linezolid | |
rplC | 800723 | c.-86C>G | upstream_gene_variant | 0.19 | linezolid | |
rplC | 801222 | c.414T>C | synonymous_variant | 0.15 | linezolid | |
rplC | 801228 | c.420T>C | synonymous_variant | 0.15 | linezolid | |
rplC | 801231 | c.423C>T | synonymous_variant | 0.16 | linezolid | |
rplC | 801246 | c.438C>T | synonymous_variant | 0.19 | linezolid | |
rplC | 801255 | c.447C>A | synonymous_variant | 0.2 | linezolid | |
rplC | 801267 | c.459A>C | synonymous_variant | 0.2 | linezolid | |
rplC | 801270 | c.462T>C | synonymous_variant | 0.2 | linezolid | |
rplC | 801273 | c.465C>G | synonymous_variant | 0.2 | linezolid | |
rplC | 801279 | c.471G>C | synonymous_variant | 0.19 | linezolid | |
rplC | 801285 | c.477G>A | synonymous_variant | 0.19 | linezolid | |
rplC | 801309 | c.501C>G | synonymous_variant | 0.15 | linezolid | |
rplC | 801312 | c.504G>C | synonymous_variant | 0.14 | linezolid | |
rplC | 801324 | c.516T>C | synonymous_variant | 0.17 | linezolid | |
Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
fbiC | 1303506 | c.576C>T | synonymous_variant | 0.14 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303512 | c.582T>C | synonymous_variant | 0.14 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303534 | p.Ser202Ala | missense_variant | 0.17 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303538 | p.Arg203Leu | missense_variant | 0.17 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303545 | c.615A>G | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303575 | c.645G>C | synonymous_variant | 0.21 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303578 | c.648G>A | synonymous_variant | 0.2 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
sigE | 1364790 | c.378T>C | synonymous_variant | 0.17 | pyrazinamide | |
sigE | 1364799 | c.387G>C | synonymous_variant | 0.16 | pyrazinamide | |
sigE | 1364919 | c.507T>C | synonymous_variant | 0.17 | pyrazinamide | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471932 | n.87A>G | non_coding_transcript_exon_variant | 0.15 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471934 | n.89A>G | non_coding_transcript_exon_variant | 0.15 | kanamycin | |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471970 | n.125G>A | non_coding_transcript_exon_variant | 0.27 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472286 | n.441C>G | non_coding_transcript_exon_variant | 0.18 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472289 | n.444T>G | non_coding_transcript_exon_variant | 0.17 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472290 | n.445C>G | non_coding_transcript_exon_variant | 0.17 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472297 | n.453_465delGTCCGGGTTCTCT | non_coding_transcript_exon_variant | 0.19 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472313 | n.468delGinsCA | non_coding_transcript_exon_variant | 0.18 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472315 | n.470T>G | non_coding_transcript_exon_variant | 0.17 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472324 | n.479G>C | non_coding_transcript_exon_variant | 0.18 | kanamycin | |
capreomycin | ||||||
streptomycin | Uncertain significance | |||||
amikacin | ||||||
rrs | 1472325 | n.480G>C | non_coding_transcript_exon_variant | 0.18 | kanamycin | |
capreomycin | ||||||
streptomycin | Uncertain significance | |||||
amikacin | ||||||
rrs | 1472328 | n.483G>C | non_coding_transcript_exon_variant | 0.18 | kanamycin | |
capreomycin | ||||||
streptomycin | Uncertain significance | |||||
amikacin | ||||||
rrs | 1472489 | n.644A>G | non_coding_transcript_exon_variant | 0.21 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472686 | n.841G>A | non_coding_transcript_exon_variant | 0.26 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472847 | n.1002G>C | non_coding_transcript_exon_variant | 0.15 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473105 | n.1260G>A | non_coding_transcript_exon_variant | 0.21 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473123 | n.1278delAinsTT | non_coding_transcript_exon_variant | 0.21 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473288 | n.1443C>T | non_coding_transcript_exon_variant | 0.31 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473290 | n.1445C>T | non_coding_transcript_exon_variant | 0.29 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473291 | n.1446G>T | non_coding_transcript_exon_variant | 0.29 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrl | 1473797 | n.140G>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1473899 | n.242A>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | ||||||
rrl | 1473918 | n.261C>T | non_coding_transcript_exon_variant | 0.31 | capreomycin | |
linezolid | ||||||
rrl | 1473924 | n.267_268insT | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | ||||||
rrl | 1473943 | n.286G>C | non_coding_transcript_exon_variant | 0.31 | capreomycin | |
linezolid | ||||||
rrl | 1473945 | n.288T>A | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473946 | n.289A>T | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473981 | n.324delGinsAT | non_coding_transcript_exon_variant | 0.3 | capreomycin | |
linezolid | ||||||
rrl | 1473994 | n.337C>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | ||||||
rrl | 1473995 | n.338G>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | ||||||
rrl | 1474001 | n.344C>T | non_coding_transcript_exon_variant | 0.3 | capreomycin | Not assoc w R |
linezolid | Not assoc w R | |||||
rrl | 1474009 | n.352A>G | non_coding_transcript_exon_variant | 0.3 | capreomycin | |
linezolid | ||||||
rrl | 1474011 | n.354G>A | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474018 | n.361G>A | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1474030 | n.373G>A | non_coding_transcript_exon_variant | 0.3 | capreomycin | |
linezolid | ||||||
rrl | 1474061 | n.404T>C | non_coding_transcript_exon_variant | 0.27 | capreomycin | |
linezolid | ||||||
rrl | 1474089 | n.432C>T | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474093 | n.436G>A | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474100 | n.443C>T | non_coding_transcript_exon_variant | 0.26 | capreomycin | |
linezolid | ||||||
rrl | 1474103 | n.446A>T | non_coding_transcript_exon_variant | 0.26 | capreomycin | |
linezolid | ||||||
rrl | 1474110 | n.453A>C | non_coding_transcript_exon_variant | 0.24 | capreomycin | |
linezolid | ||||||
rrl | 1474111 | n.454T>C | non_coding_transcript_exon_variant | 0.27 | capreomycin | |
linezolid | ||||||
rrl | 1474130 | n.473C>T | non_coding_transcript_exon_variant | 0.25 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474140 | n.483C>T | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474151 | n.494C>T | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474181 | n.524C>T | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474249 | n.592G>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474409 | n.756_774delACCCACACGCGCATACGCG | non_coding_transcript_exon_variant | 0.2 | capreomycin | |
linezolid | ||||||
rrl | 1474433 | n.776G>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1474435 | n.779_783delTGAAT | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1474447 | n.790G>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1474627 | n.970G>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474632 | n.975G>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474639 | n.982G>A | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474783 | n.1126G>A | non_coding_transcript_exon_variant | 0.25 | capreomycin | |
linezolid | ||||||
rrl | 1475018 | n.1361G>A | non_coding_transcript_exon_variant | 0.23 | capreomycin | |
linezolid | ||||||
rrl | 1475027 | n.1370G>T | non_coding_transcript_exon_variant | 0.25 | capreomycin | |
linezolid | ||||||
rrl | 1475028 | n.1371G>T | non_coding_transcript_exon_variant | 0.25 | capreomycin | |
linezolid | ||||||
rrl | 1475061 | n.1404C>T | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475642 | n.1985T>C | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1475657 | n.2000A>G | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1475659 | n.2002G>A | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475760 | n.2103C>T | non_coding_transcript_exon_variant | 0.27 | capreomycin | |
linezolid | ||||||
rrl | 1475763 | n.2106C>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475881 | n.2224T>C | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1475988 | n.2331A>G | non_coding_transcript_exon_variant | 0.18 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1475999 | n.2342G>T | non_coding_transcript_exon_variant | 0.22 | capreomycin | |
linezolid | ||||||
rrl | 1476030 | n.2373A>G | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476032 | n.2375C>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476033 | n.2376T>C | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476034 | n.2377C>G | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476045 | n.2388G>C | non_coding_transcript_exon_variant | 0.2 | capreomycin | |
linezolid | ||||||
rrl | 1476047 | n.2390G>A | non_coding_transcript_exon_variant | 0.2 | capreomycin | |
linezolid | ||||||
rrl | 1476049 | n.2392C>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476251 | n.2594T>C | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476580 | n.2923G>A | non_coding_transcript_exon_variant | 0.25 | capreomycin | |
linezolid | ||||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476619 | n.2962C>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
inhA | 1674601 | p.Leu134Val | missense_variant | 0.15 | isoniazid | |
ethionamide | ||||||
inhA | 1674618 | c.417C>T | synonymous_variant | 0.19 | isoniazid | |
ethionamide | ||||||
inhA | 1674624 | c.423A>T | synonymous_variant | 0.18 | isoniazid | |
ethionamide | ||||||
inhA | 1674627 | c.426T>C | synonymous_variant | 0.18 | isoniazid | |
ethionamide | ||||||
inhA | 1674655 | c.454_456delAGCinsTCG | synonymous_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1674669 | c.468G>C | synonymous_variant | 0.2 | isoniazid | |
ethionamide | ||||||
inhA | 1674687 | c.486G>A | synonymous_variant | 0.18 | isoniazid | Not assoc w R - Interim |
ethionamide | Not assoc w R - Interim | |||||
inhA | 1674690 | c.489C>G | synonymous_variant | 0.19 | isoniazid | |
ethionamide | ||||||
inhA | 1674693 | c.492C>T | synonymous_variant | 0.2 | isoniazid | |
ethionamide | ||||||
inhA | 1674696 | c.495G>A | synonymous_variant | 0.2 | isoniazid | |
ethionamide | ||||||
inhA | 1674703 | c.502T>C | synonymous_variant | 0.22 | isoniazid | |
ethionamide | ||||||
inhA | 1674718 | c.517A>C | synonymous_variant | 0.2 | isoniazid | |
ethionamide | ||||||
inhA | 1674729 | c.528G>A | synonymous_variant | 0.24 | isoniazid | |
ethionamide | ||||||
inhA | 1674745 | p.Tyr182Ala | missense_variant | 0.18 | isoniazid | |
ethionamide | ||||||
inhA | 1674756 | c.555T>C | synonymous_variant | 0.18 | isoniazid | Not assoc w R - Interim |
ethionamide | Not assoc w R - Interim | |||||
inhA | 1674759 | c.558G>C | synonymous_variant | 0.18 | isoniazid | |
ethionamide | ||||||
inhA | 1674765 | c.564C>T | synonymous_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1674774 | c.573A>C | synonymous_variant | 0.15 | isoniazid | |
ethionamide | ||||||
rpsA | 1833895 | c.354G>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1833916 | c.375C>T | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1833949 | c.408T>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1833970 | c.429G>A | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834000 | c.459G>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834015 | c.474G>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834021 | c.480C>T | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834225 | c.684C>G | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834231 | c.690T>G | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834249 | c.708T>C | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834261 | c.720A>G | synonymous_variant | 0.16 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834297 | c.756C>T | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1834303 | c.762T>G | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834336 | c.795C>G | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834348 | c.807T>C | synonymous_variant | 0.25 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.23 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834375 | c.834G>A | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834396 | c.855G>T | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834411 | c.870T>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834423 | c.882G>T | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834451 | c.910T>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834456 | c.915T>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834465 | c.924T>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834477 | c.936C>T | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834510 | c.969C>T | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834519 | c.978G>C | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.37 | pyrazinamide | |
rpsA | 1834555 | c.1014T>G | synonymous_variant | 0.36 | pyrazinamide | |
rpsA | 1834603 | c.1062G>A | synonymous_variant | 0.36 | pyrazinamide | |
rpsA | 1834609 | c.1068T>C | synonymous_variant | 0.37 | pyrazinamide | |
rpsA | 1834612 | c.1071G>A | synonymous_variant | 0.36 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834633 | c.1092A>G | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1834639 | c.1098T>C | synonymous_variant | 0.33 | pyrazinamide | |
rpsA | 1834654 | c.1113G>A | synonymous_variant | 0.3 | pyrazinamide | |
rpsA | 1834690 | c.1149T>C | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834699 | p.Glu386Asp | missense_variant | 0.19 | pyrazinamide | |
rpsA | 1834708 | c.1167C>T | synonymous_variant | 0.17 | pyrazinamide | |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
ndh | 2101804 | c.1239T>G | synonymous_variant | 0.19 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2101825 | c.1218G>A | synonymous_variant | 0.22 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2101837 | p.Ala402Val | missense_variant | 0.18 | isoniazid | Uncertain significance |
delamanid | ||||||
ethionamide | Uncertain significance | |||||
ndh | 2101858 | p.Ile395Met | missense_variant | 0.21 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2101873 | c.1170T>C | synonymous_variant | 0.2 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2101879 | c.1164C>T | synonymous_variant | 0.19 | isoniazid | Not assoc w R - Interim |
delamanid | ||||||
ethionamide | Not assoc w R - Interim | |||||
ndh | 2101890 | p.Val385Leu | missense_variant | 0.16 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2101894 | c.1149T>C | synonymous_variant | 0.14 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
katG | 2156830 | c.-719G>A | upstream_gene_variant | 0.98 | isoniazid | |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
PPE35 | 2168651 | p.Leu654Phe | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
pncA | 2289047 | c.195C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R |
pncA | 2289365 | c.-125delC | upstream_gene_variant | 1.0 | pyrazinamide | |
kasA | 2518528 | c.414C>G | synonymous_variant | 0.18 | isoniazid | |
kasA | 2518534 | c.420G>C | synonymous_variant | 0.18 | isoniazid | |
kasA | 2518651 | c.537C>G | synonymous_variant | 0.14 | isoniazid | |
kasA | 2518657 | c.543G>C | synonymous_variant | 0.14 | isoniazid | |
kasA | 2518663 | c.549T>C | synonymous_variant | 0.15 | isoniazid | |
kasA | 2518693 | c.579C>G | synonymous_variant | 0.15 | isoniazid | |
kasA | 2518702 | c.588C>T | synonymous_variant | 0.16 | isoniazid | |
kasA | 2518711 | c.597A>G | synonymous_variant | 0.16 | isoniazid | |
kasA | 2518714 | c.600A>C | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518717 | c.603C>G | synonymous_variant | 0.18 | isoniazid | |
kasA | 2518723 | c.609G>A | synonymous_variant | 0.18 | isoniazid | |
kasA | 2518735 | c.621C>T | synonymous_variant | 0.16 | isoniazid | |
kasA | 2518747 | c.633C>G | synonymous_variant | 0.18 | isoniazid | |
kasA | 2518768 | c.654C>G | synonymous_variant | 0.19 | isoniazid | |
kasA | 2518783 | c.669T>C | synonymous_variant | 0.16 | isoniazid | |
kasA | 2518789 | c.675G>T | synonymous_variant | 0.18 | isoniazid | |
kasA | 2518795 | c.681C>A | synonymous_variant | 0.17 | isoniazid | |
kasA | 2518798 | c.684G>C | synonymous_variant | 0.17 | isoniazid | |
ahpC | 2726105 | c.-88G>A | upstream_gene_variant | 1.0 | isoniazid | Not assoc w R |
Rv2477c | 2782498 | c.1545C>T | synonymous_variant | 1.0 | kanamycin | Not assoc w R |
levofloxacin | Not assoc w R | |||||
moxifloxacin | Not assoc w R | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R | |||||
ethambutol | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
Rv2477c | 2783881 | c.160_162delTTGinsCTC | synonymous_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783884 | c.159T>G | synonymous_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783920 | c.123G>T | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2783938 | c.105T>C | synonymous_variant | 0.17 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783956 | p.Tyr29Phe | missense_variant | 0.15 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783971 | c.72G>C | synonymous_variant | 0.14 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
pepQ | 2860399 | p.Arg7Gln | missense_variant | 0.98 | bedaquiline | Uncertain significance |
clofazimine | Uncertain significance | |||||
Rv2752c | 3065040 | c.1150_1152delCTCinsTTG | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3065049 | c.1143G>A | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3065055 | c.1137T>G | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3065061 | c.1131C>T | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3065064 | c.1128G>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
Rv2752c | 3065070 | c.1122C>A | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3065073 | c.1119C>G | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
Rv2752c | 3065085 | c.1105_1107delAGGinsCGC | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3065088 | c.1104A>G | synonymous_variant | 0.17 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
isoniazid | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
Rv2752c | 3065097 | c.1095C>T | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3065106 | c.1086C>G | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3065109 | c.1081_1083delAGAinsCGG | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3065130 | c.1062A>G | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3065133 | c.1059T>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3065142 | c.1050A>C | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
isoniazid | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
Rv2752c | 3065146 | p.Phe349Tyr | missense_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
thyA | 3073925 | c.547T>C | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyA | 3073944 | c.528C>T | synonymous_variant | 0.14 | para-aminosalicylic_acid | |
thyA | 3073959 | c.513T>C | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
mtrB | 3625065 | p.Met517Leu | missense_variant | 0.97 | rifampicin | Not assoc w R |
bedaquiline | Uncertain significance | |||||
mtrB | 3626933 | c.-320C>T | upstream_gene_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626942 | c.-329A>C | upstream_gene_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626969 | c.-356C>G | upstream_gene_variant | 0.19 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626972 | c.-359A>G | upstream_gene_variant | 0.19 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626987 | c.-374C>G | upstream_gene_variant | 0.18 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627008 | c.-395G>C | upstream_gene_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627011 | c.-398T>G | upstream_gene_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627023 | c.-410C>G | upstream_gene_variant | 0.18 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627059 | c.-446G>C | upstream_gene_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627068 | c.282T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrA | 3627080 | c.270T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrA | 3627098 | c.252A>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627101 | c.-488C>G | upstream_gene_variant | 0.18 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627104 | c.-491C>G | upstream_gene_variant | 0.18 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627110 | c.-497G>C | upstream_gene_variant | 0.19 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627122 | c.-509T>C | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627128 | c.-515T>C | upstream_gene_variant | 0.23 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627137 | c.-526_-524delTTGinsCTA | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627143 | c.-530G>C | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627167 | c.-554T>C | upstream_gene_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
alr | 3841473 | c.-53G>A | upstream_gene_variant | 1.0 | cycloserine | |
rpoA | 3877758 | c.750G>C | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3877764 | c.744C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3877770 | c.738A>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoA | 3877776 | c.732T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoA | 3877782 | c.726T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoA | 3877815 | c.693C>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoA | 3877839 | c.669G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3877857 | c.651G>A | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3877865 | c.643C>T | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3877866 | c.642G>C | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3877872 | c.636C>T | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoA | 3877875 | c.633T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoA | 3877887 | c.621G>C | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3877900 | p.Ser203Thr | missense_variant | 0.2 | rifampicin | |
rpoA | 3877905 | c.603A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3878001 | c.507A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoA | 3878313 | c.195G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoA | 3878322 | c.186A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoA | 3878331 | c.177A>C | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878334 | c.174T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoA | 3878337 | c.171T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoA | 3878346 | c.162T>C | synonymous_variant | 0.24 | rifampicin | |
rpoA | 3878364 | c.144A>C | synonymous_variant | 0.27 | rifampicin | |
rpoA | 3878370 | c.138T>C | synonymous_variant | 0.29 | rifampicin | |
rpoA | 3878376 | c.132G>C | synonymous_variant | 0.28 | rifampicin | |
rpoA | 3878384 | c.124C>T | synonymous_variant | 0.29 | rifampicin | |
rpoA | 3878385 | c.123C>G | synonymous_variant | 0.3 | rifampicin | |
rpoA | 3878391 | c.117T>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoA | 3879037 | c.-530G>A | upstream_gene_variant | 0.25 | rifampicin | |
rpoA | 3879049 | c.-542A>G | upstream_gene_variant | 0.25 | rifampicin | |
rpoA | 3879079 | c.-572A>G | upstream_gene_variant | 0.26 | rifampicin | |
rpoA | 3879088 | c.-581A>C | upstream_gene_variant | 0.27 | rifampicin | |
rpoA | 3879094 | c.-587T>C | upstream_gene_variant | 0.24 | rifampicin | |
rpoA | 3879117 | c.-610C>T | upstream_gene_variant | 0.24 | rifampicin | |
rpoA | 3879121 | c.-614T>G | upstream_gene_variant | 0.24 | rifampicin | |
rpoA | 3879127 | c.-620T>C | upstream_gene_variant | 0.23 | rifampicin | |
rpoA | 3879145 | c.-638G>C | upstream_gene_variant | 0.2 | rifampicin | |
rpoA | 3879148 | c.-641G>C | upstream_gene_variant | 0.19 | rifampicin | |
rpoA | 3879154 | c.-647T>C | upstream_gene_variant | 0.19 | rifampicin | |
rpoA | 3879160 | c.-653A>G | upstream_gene_variant | 0.17 | rifampicin | |
clpC1 | 4038749 | c.1956C>T | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038809 | c.1896G>A | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038875 | c.1830C>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.22 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038893 | c.1812C>T | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038908 | c.1797C>G | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4038914 | c.1791G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038923 | c.1782A>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038997 | c.1708T>C | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039004 | c.1701C>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039085 | c.1620A>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039097 | c.1608G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039106 | c.1599G>T | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039112 | c.1593C>A | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039119 | c.1585_1586delTCinsAG | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039121 | c.1584T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039124 | c.1581C>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039142 | c.1563A>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039169 | p.Glu512Asp | missense_variant | 0.16 | pyrazinamide | |
clpC1 | 4039172 | c.1533A>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039178 | c.1527G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039183 | c.1522T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039190 | c.1515C>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4039193 | c.1512C>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039223 | c.1482C>T | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039226 | c.1479T>C | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039238 | c.1467C>T | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4039243 | c.1462C>T | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039259 | c.1446G>A | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039262 | c.1443C>T | synonymous_variant | 0.24 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039268 | c.1437C>T | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4039274 | c.1431G>C | synonymous_variant | 0.24 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039286 | c.1419T>C | synonymous_variant | 0.3 | pyrazinamide | |
clpC1 | 4039298 | c.1407T>C | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039304 | c.1401G>A | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4039313 | c.1392C>T | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039319 | p.Ala462Thr | missense_variant | 0.25 | pyrazinamide | |
clpC1 | 4039322 | c.1383T>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039328 | c.1377A>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039338 | p.Thr456Gln | missense_variant | 0.24 | pyrazinamide | |
clpC1 | 4039361 | c.1344C>A | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039382 | c.1323C>T | synonymous_variant | 0.13 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039454 | c.1251A>G | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039463 | c.1242C>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039466 | c.1239T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039469 | c.1236T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039472 | c.1233G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039481 | c.1224T>G | synonymous_variant | 0.14 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039484 | c.1221T>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040000 | c.705C>T | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040015 | c.690G>A | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040021 | c.684A>C | synonymous_variant | 0.14 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040024 | c.681A>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040033 | c.672G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040090 | c.613_615delTCTinsAGC | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040093 | c.612C>G | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040105 | c.600C>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040147 | c.558A>G | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040162 | c.543G>C | synonymous_variant | 0.19 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040165 | c.540G>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4040171 | c.534C>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4040195 | c.510G>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040201 | c.504C>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4040204 | c.501G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040207 | c.498T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040213 | c.490_492delTCTinsAGC | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040225 | c.480A>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040228 | c.477G>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040231 | c.474C>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040246 | c.459C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040249 | c.456A>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040551 | c.154T>C | synonymous_variant | 0.24 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040561 | c.144A>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4040573 | c.132T>A | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4040579 | c.126A>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4040582 | c.123G>C | synonymous_variant | 0.19 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040588 | c.117T>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040591 | c.114C>T | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040597 | c.108C>T | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040600 | c.103_105delTTAinsCTG | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040603 | c.102T>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040606 | c.99T>C | synonymous_variant | 0.18 | pyrazinamide | |
panD | 4044177 | c.105C>G | synonymous_variant | 0.16 | pyrazinamide | Not assoc w R - Interim |
panD | 4044180 | c.102C>T | synonymous_variant | 0.18 | pyrazinamide | |
panD | 4044188 | c.94T>C | synonymous_variant | 0.18 | pyrazinamide | |
panD | 4044195 | c.87T>C | synonymous_variant | 0.19 | pyrazinamide | |
panD | 4044225 | c.57C>T | synonymous_variant | 0.19 | pyrazinamide | |
panD | 4044231 | p.Cys17Gln | missense_variant | 0.18 | pyrazinamide | |
panD | 4044237 | c.45G>C | synonymous_variant | 0.15 | pyrazinamide | |
panD | 4044872 | c.-591C>T | upstream_gene_variant | 0.97 | pyrazinamide | |
glpK | 4138606 | c.1150T>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138622 | c.1134C>T | synonymous_variant | 0.85 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R | |||||
ethambutol | Not assoc w R | |||||
glpK | 4138631 | c.1125C>G | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139165 | c.591A>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139168 | c.588T>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139176 | p.Val194Ile | missense_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139177 | c.579T>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139183 | c.573T>G | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139186 | c.570G>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
glpK | 4139215 | c.541T>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139223 | p.Thr178Ser | missense_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139230 | p.Pro176Ala | missense_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139231 | c.525A>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139243 | c.513A>G | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
embC | 4242075 | p.Arg738Gln | missense_variant | 1.0 | ethambutol | Not assoc w R |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embA | 4245089 | c.1857G>C | synonymous_variant | 0.15 | ethambutol | |
embA | 4245093 | p.Ile621Val | missense_variant | 0.15 | ethambutol | Uncertain significance |
embA | 4245101 | c.1869G>C | synonymous_variant | 0.16 | ethambutol | |
embA | 4245125 | c.1893G>C | synonymous_variant | 0.15 | ethambutol | |
embA | 4245137 | c.1905T>C | synonymous_variant | 0.15 | ethambutol | |
embA | 4245149 | c.1917C>G | synonymous_variant | 0.15 | ethambutol | |
embB | 4247470 | c.957T>C | synonymous_variant | 0.17 | ethambutol | |
embB | 4247497 | c.984T>C | synonymous_variant | 0.15 | ethambutol | |
embB | 4247506 | c.993C>G | synonymous_variant | 0.17 | ethambutol | |
embB | 4248097 | c.1584C>G | synonymous_variant | 0.15 | ethambutol | |
embB | 4248190 | c.1677G>C | synonymous_variant | 0.15 | ethambutol | Not assoc w R - Interim |
embB | 4248206 | p.Ser565Gly | missense_variant | 0.14 | ethambutol | Uncertain significance |
embB | 4248211 | c.1698G>A | synonymous_variant | 0.14 | ethambutol | |
embB | 4248277 | c.1764G>C | synonymous_variant | 0.14 | ethambutol | |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |