TB-Profiler result

Run: SRR17832802
Summary

Run ID: SRR17832802

Sample name:

Date: 2024-10-04T05:54:30.282951

Number of reads: 2643467

Percentage reads mapped: 74.74

Median coverage: 64.0

Strain: lineage3

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin gid p.Cys52* Assoc w R
fluoroquinolones
moxifloxacin gyrA p.Asp94Asn Assoc w R High-level resistance
ofloxacin
levofloxacin gyrA p.Asp94Asn Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7581 p.Asp94Asn missense_variant 0.65 levofloxacin Assoc w R
moxifloxacin Assoc w R High-level resistance
katG 2155168 p.Ser315Thr missense_variant 0.98 isoniazid Assoc w R High-level resistance
gid 4408047 p.Cys52* stop_gained 1.0 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6190 c.951A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7433 c.132G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7469 c.168C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7475 c.174A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7502 c.201C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7526 c.225G>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7626 c.325C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7643 c.342C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7646 c.345C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7655 c.354G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7661 c.360C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7673 c.372G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7742 c.441G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7769 c.468C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8555 c.1254G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
nusG 734478 c.225C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760181 c.375T>A synonymous_variant 0.17 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.21 rifampicin
rpoB 760295 c.489C>T synonymous_variant 0.18 rifampicin
rpoB 760307 c.501T>C synonymous_variant 0.19 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.19 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.17 rifampicin
rpoB 760381 p.Thr192Met missense_variant 0.15 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.15 rifampicin
rpoB 760601 c.795C>T synonymous_variant 0.16 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760769 c.963C>G synonymous_variant 0.13 rifampicin
rpoB 760937 c.1131G>A synonymous_variant 0.18 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.22 rifampicin
rpoB 760982 c.1176G>T synonymous_variant 0.25 rifampicin
rpoB 760985 c.1179G>T synonymous_variant 0.25 rifampicin
rpoB 760991 c.1185G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>T synonymous_variant 0.27 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.25 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>G synonymous_variant 0.15 rifampicin
rpoB 761192 c.1386C>G synonymous_variant 0.15 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761240 c.1434C>T synonymous_variant 0.17 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>C synonymous_variant 0.17 rifampicin
rpoB 761261 c.1455G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.14 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.15 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.17 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761750 c.1944G>C synonymous_variant 0.16 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.18 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.17 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.17 rifampicin
rpoB 761828 c.2022C>T synonymous_variant 0.15 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.16 rifampicin
rpoB 761837 c.2031C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>C synonymous_variant 0.18 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.21 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>G synonymous_variant 0.19 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.18 rifampicin
rpoB 762047 c.2241G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.25 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.22 rifampicin
rpoB 762134 c.2328C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.2 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>T synonymous_variant 0.25 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.26 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.26 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.25 rifampicin
rpoB 762281 c.2475G>A synonymous_variant 0.26 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.24 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.25 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.26 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.18 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.13 rifampicin
rpoB 762434 c.2628T>G synonymous_variant 0.91 rifampicin Not assoc w R
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763402 c.33C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763409 c.40_42delCTTinsTTG synonymous_variant 0.21 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.21 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.2 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.16 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.16 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.2 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.2 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.22 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.21 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.2 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.21 rifampicin
rpoC 763936 c.567C>G synonymous_variant 0.16 rifampicin
rpoC 763939 c.570G>A synonymous_variant 0.16 rifampicin
rpoC 763951 c.582G>A synonymous_variant 0.17 rifampicin
rpoC 763963 c.594C>G synonymous_variant 0.15 rifampicin
rpoC 763967 p.Gly200Ser missense_variant 0.17 rifampicin
rpoC 763972 c.603C>T synonymous_variant 0.16 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.16 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.14 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.17 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.16 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.16 rifampicin
rpoC 764044 c.675T>G synonymous_variant 0.17 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.16 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.15 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764159 c.790C>T synonymous_variant 0.18 rifampicin
rpoC 764215 c.846A>C synonymous_variant 0.14 rifampicin
rpoC 764218 c.849C>T synonymous_variant 0.14 rifampicin
rpoC 764242 c.873C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.16 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.17 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.17 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.21 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.2 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.21 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.22 rifampicin
rpoC 764605 c.1236G>A synonymous_variant 0.24 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764647 c.1278C>T synonymous_variant 0.25 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764686 c.1317C>T synonymous_variant 0.33 rifampicin
rpoC 764696 c.1327C>T synonymous_variant 0.3 rifampicin
rpoC 764746 c.1377G>C synonymous_variant 0.21 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCTC synonymous_variant 0.21 rifampicin
rpoC 764896 c.1527C>T synonymous_variant 0.23 rifampicin
rpoC 764902 c.1533C>T synonymous_variant 0.22 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.22 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.21 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765319 c.1950A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765328 p.His653Gln missense_variant 0.17 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.16 rifampicin Uncertain significance
rpoC 765334 c.1965C>T synonymous_variant 0.16 rifampicin
rpoC 765343 c.1974G>A synonymous_variant 0.16 rifampicin
rpoC 765352 c.1983G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765406 c.2037G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765409 c.2040T>C synonymous_variant 0.15 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.15 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Ser missense_variant 0.16 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765517 c.2148C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.16 rifampicin
rpoC 765728 p.Gln787Lys missense_variant 0.17 rifampicin
rpoC 765734 c.2365T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765752 p.Asp795Ser missense_variant 0.2 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.23 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.22 rifampicin
rpoC 765790 c.2421C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765793 c.2424C>G synonymous_variant 0.22 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.22 rifampicin
rpoC 765811 c.2442T>A synonymous_variant 0.17 rifampicin
rpoC 765814 c.2445A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766381 c.3012C>T synonymous_variant 0.16 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.16 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.16 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.21 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.26 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.34 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.35 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.35 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.38 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.33 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.33 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.29 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.24 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.24 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.24 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.19 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.19 rifampicin
rpoC 766700 c.3331C>T synonymous_variant 0.24 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.24 rifampicin
rpoC 766733 c.3364C>T synonymous_variant 0.24 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.24 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.24 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.26 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.26 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766801 c.3432C>G synonymous_variant 0.28 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.24 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766883 p.Ser1172Ala missense_variant 0.26 rifampicin Uncertain significance
rpoC 766894 c.3525T>C synonymous_variant 0.24 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.22 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.2 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.22 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.26 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>G synonymous_variant 0.22 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767014 c.3645G>C synonymous_variant 0.22 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.19 rifampicin
rpoC 767149 c.3780C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>A synonymous_variant 0.15 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775981 p.Leu834Met missense_variant 0.17 bedaquiline
clofazimine
mmpL5 776009 c.2472A>G synonymous_variant 0.17 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 777820 c.661C>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781766 c.207C>T synonymous_variant 0.17 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>G synonymous_variant 0.16 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.17 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.15 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.17 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.15 streptomycin Not assoc w R - Interim
rpsL 781850 c.291C>A synonymous_variant 0.16 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.18 streptomycin
rplC 800612 c.-197A>G upstream_gene_variant 0.16 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.16 linezolid
rplC 800621 c.-188G>A upstream_gene_variant 0.16 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.18 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.19 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.2 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.21 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.23 linezolid
rplC 800714 c.-95C>T upstream_gene_variant 0.2 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.2 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.19 linezolid
rplC 801222 c.414T>C synonymous_variant 0.15 linezolid
rplC 801228 c.420T>C synonymous_variant 0.15 linezolid
rplC 801231 c.423C>T synonymous_variant 0.16 linezolid
rplC 801246 c.438C>T synonymous_variant 0.19 linezolid
rplC 801255 c.447C>A synonymous_variant 0.2 linezolid
rplC 801267 c.459A>C synonymous_variant 0.2 linezolid
rplC 801270 c.462T>C synonymous_variant 0.2 linezolid
rplC 801273 c.465C>G synonymous_variant 0.2 linezolid
rplC 801279 c.471G>C synonymous_variant 0.19 linezolid
rplC 801285 c.477G>A synonymous_variant 0.19 linezolid
rplC 801309 c.501C>G synonymous_variant 0.15 linezolid
rplC 801312 c.504G>C synonymous_variant 0.14 linezolid
rplC 801324 c.516T>C synonymous_variant 0.17 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303506 c.576C>T synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1303512 c.582T>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1303534 p.Ser202Ala missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303538 p.Arg203Leu missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303578 c.648G>A synonymous_variant 0.2 pretomanid
delamanid
clofazimine
sigE 1364790 c.378T>C synonymous_variant 0.17 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.16 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.17 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.15 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.15 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.18 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473797 n.140G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473899 n.242A>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473918 n.261C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473943 n.286G>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1473981 n.324delGinsAT non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473994 n.337C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.3 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474011 n.354G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474018 n.361G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474030 n.373G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474061 n.404T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474089 n.432C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474100 n.443C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474110 n.453A>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474409 n.756_774delACCCACACGCGCATACGCG non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474433 n.776G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474435 n.779_783delTGAAT non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474447 n.790G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475018 n.1361G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475027 n.1370G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475028 n.1371G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2103C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.18 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475999 n.2342G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476047 n.2390G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.18 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674601 p.Leu134Val missense_variant 0.15 isoniazid
ethionamide
inhA 1674618 c.417C>T synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674624 c.423A>T synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674627 c.426T>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674655 c.454_456delAGCinsTCG synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674669 c.468G>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674687 c.486G>A synonymous_variant 0.18 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674690 c.489C>G synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674693 c.492C>T synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674696 c.495G>A synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674729 c.528G>A synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674745 p.Tyr182Ala missense_variant 0.18 isoniazid
ethionamide
inhA 1674756 c.555T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674759 c.558G>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674765 c.564C>T synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674774 c.573A>C synonymous_variant 0.15 isoniazid
ethionamide
rpsA 1833895 c.354G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833916 c.375C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833970 c.429G>A synonymous_variant 0.22 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.18 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.16 pyrazinamide
rpsA 1834336 c.795C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.23 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.19 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.18 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.17 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834510 c.969C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834519 c.978G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.36 pyrazinamide
rpsA 1834603 c.1062G>A synonymous_variant 0.36 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834633 c.1092A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834654 c.1113G>A synonymous_variant 0.3 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834699 p.Glu386Asp missense_variant 0.19 pyrazinamide
rpsA 1834708 c.1167C>T synonymous_variant 0.17 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2101804 c.1239T>G synonymous_variant 0.19 isoniazid
delamanid
ethionamide
ndh 2101825 c.1218G>A synonymous_variant 0.22 isoniazid
delamanid
ethionamide
ndh 2101837 p.Ala402Val missense_variant 0.18 isoniazid Uncertain significance
delamanid
ethionamide Uncertain significance
ndh 2101858 p.Ile395Met missense_variant 0.21 isoniazid
delamanid
ethionamide
ndh 2101873 c.1170T>C synonymous_variant 0.2 isoniazid
delamanid
ethionamide
ndh 2101879 c.1164C>T synonymous_variant 0.19 isoniazid Not assoc w R - Interim
delamanid
ethionamide Not assoc w R - Interim
ndh 2101890 p.Val385Leu missense_variant 0.16 isoniazid
delamanid
ethionamide
ndh 2101894 c.1149T>C synonymous_variant 0.14 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2156830 c.-719G>A upstream_gene_variant 0.98 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168651 p.Leu654Phe missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
kasA 2518528 c.414C>G synonymous_variant 0.18 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.18 isoniazid
kasA 2518651 c.537C>G synonymous_variant 0.14 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.14 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.15 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.15 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.16 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.16 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.17 isoniazid
kasA 2518717 c.603C>G synonymous_variant 0.18 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.18 isoniazid
kasA 2518735 c.621C>T synonymous_variant 0.16 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.18 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.19 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.16 isoniazid
kasA 2518789 c.675G>T synonymous_variant 0.18 isoniazid
kasA 2518795 c.681C>A synonymous_variant 0.17 isoniazid
kasA 2518798 c.684G>C synonymous_variant 0.17 isoniazid
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv2477c 2782498 c.1545C>T synonymous_variant 1.0 kanamycin Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
amikacin Not assoc w R
Rv2477c 2783881 c.160_162delTTGinsCTC synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>T synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783956 p.Tyr29Phe missense_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
pepQ 2860399 p.Arg7Gln missense_variant 0.98 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv2752c 3065040 c.1150_1152delCTCinsTTG synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065049 c.1143G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065055 c.1137T>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065061 c.1131C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065064 c.1128G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065070 c.1122C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065073 c.1119C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065085 c.1105_1107delAGGinsCGC synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065088 c.1104A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065097 c.1095C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065106 c.1086C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065109 c.1081_1083delAGAinsCGG synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065130 c.1062A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065133 c.1059T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065142 c.1050A>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065146 p.Phe349Tyr missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyA 3073925 c.547T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073944 c.528C>T synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.15 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 0.97 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626933 c.-320C>T upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3626969 c.-356C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627023 c.-410C>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627059 c.-446G>C upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627101 c.-488C>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627110 c.-497G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627137 c.-526_-524delTTGinsCTA upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627143 c.-530G>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
alr 3841473 c.-53G>A upstream_gene_variant 1.0 cycloserine
rpoA 3877758 c.750G>C synonymous_variant 0.21 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877815 c.693C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.21 rifampicin
rpoA 3877865 c.643C>T synonymous_variant 0.18 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.18 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877887 c.621G>C synonymous_variant 0.23 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.2 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>C synonymous_variant 0.22 rifampicin
rpoA 3878334 c.174T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.24 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.27 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.29 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.28 rifampicin
rpoA 3878384 c.124C>T synonymous_variant 0.29 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.3 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3879037 c.-530G>A upstream_gene_variant 0.25 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.27 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.24 rifampicin
rpoA 3879117 c.-610C>T upstream_gene_variant 0.24 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.24 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879145 c.-638G>C upstream_gene_variant 0.2 rifampicin
rpoA 3879148 c.-641G>C upstream_gene_variant 0.19 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.17 rifampicin
clpC1 4038749 c.1956C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038773 c.1932T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038809 c.1896G>A synonymous_variant 0.17 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038875 c.1830C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4038893 c.1812C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039106 c.1599G>T synonymous_variant 0.19 pyrazinamide
clpC1 4039112 c.1593C>A synonymous_variant 0.2 pyrazinamide
clpC1 4039119 c.1585_1586delTCinsAG synonymous_variant 0.16 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.16 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039193 c.1512C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039223 c.1482C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039238 c.1467C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039243 c.1462C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039259 c.1446G>A synonymous_variant 0.22 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039268 c.1437C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.27 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039319 p.Ala462Thr missense_variant 0.25 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.24 pyrazinamide
clpC1 4039361 c.1344C>A synonymous_variant 0.21 pyrazinamide
clpC1 4039382 c.1323C>T synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>G synonymous_variant 0.15 pyrazinamide
clpC1 4040000 c.705C>T synonymous_variant 0.17 pyrazinamide
clpC1 4040015 c.690G>A synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040021 c.684A>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.15 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040195 c.510G>T synonymous_variant 0.15 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.14 pyrazinamide
clpC1 4040204 c.501G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.16 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.15 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040231 c.474C>T synonymous_variant 0.15 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.15 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.19 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040588 c.117T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040591 c.114C>T synonymous_variant 0.17 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.17 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCTG synonymous_variant 0.17 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.17 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.18 pyrazinamide
panD 4044177 c.105C>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
panD 4044180 c.102C>T synonymous_variant 0.18 pyrazinamide
panD 4044188 c.94T>C synonymous_variant 0.18 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.19 pyrazinamide
panD 4044225 c.57C>T synonymous_variant 0.19 pyrazinamide
panD 4044231 p.Cys17Gln missense_variant 0.18 pyrazinamide
panD 4044237 c.45G>C synonymous_variant 0.15 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 0.97 pyrazinamide
glpK 4138606 c.1150T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138622 c.1134C>T synonymous_variant 0.85 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
glpK 4138631 c.1125C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139165 c.591A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139168 c.588T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139176 p.Val194Ile missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139177 c.579T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139183 c.573T>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139186 c.570G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4139215 c.541T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139223 p.Thr178Ser missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139230 p.Pro176Ala missense_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139231 c.525A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139243 c.513A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245089 c.1857G>C synonymous_variant 0.15 ethambutol
embA 4245093 p.Ile621Val missense_variant 0.15 ethambutol Uncertain significance
embA 4245101 c.1869G>C synonymous_variant 0.16 ethambutol
embA 4245125 c.1893G>C synonymous_variant 0.15 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.15 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.15 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.17 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.15 ethambutol
embB 4247506 c.993C>G synonymous_variant 0.17 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.15 ethambutol
embB 4248190 c.1677G>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248206 p.Ser565Gly missense_variant 0.14 ethambutol Uncertain significance
embB 4248211 c.1698G>A synonymous_variant 0.14 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.14 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R