TB-Profiler result

Run: SRR26937071
Summary

Run ID: SRR26937071

Sample name:

Date: 2024-03-27T00:18:48.616551

Number of reads: 2399182

Percentage reads mapped: 72.53

Median coverage: 84.0

Strain: La3;lineage2.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.97
La1.2.BCG M.bovis None 0.33
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 0.96
La3 M.orygis None 0.12
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embA c.-16C>T Uncertain significance Mutation from literature
embB p.His312Arg Mutation from literature
p.Asp1024Asn Uncertain significance Mutation from literature
pyrazinamide pncA p.Trp68Gly Assoc w R
streptomycin rpsL p.Lys43Arg Assoc w R
rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 0.74 rifampicin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 0.41 streptomycin Assoc w R
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 0.97 isoniazid Assoc w R High-level resistance
pncA 2289040 p.Trp68Gly missense_variant 1.0 pyrazinamide Assoc w R
embA 4243217 c.-16C>T upstream_gene_variant 1.0 ethambutol Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.36 ethambutol Mutation from literature
embB 4249583 p.Asp1024Asn missense_variant 0.74 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6745 c.1506T>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8189 c.888G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8270 c.969G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491601 c.819T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575907 p.Ala187Val missense_variant 1.0 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620340 c.450C>G synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>A synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620389 c.499C>T synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620424 c.534G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620436 c.546T>A synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 656192 p.Asp427Asn missense_variant 0.22 ethionamide Uncertain significance
Rv0565c 656196 p.Leu425Arg missense_variant 0.22 ethionamide
Rv0565c 656219 p.His418Tyr missense_variant 0.32 ethionamide
Rv0565c 656220 c.1251A>C synonymous_variant 0.32 ethionamide
Rv0565c 656223 c.1248T>C synonymous_variant 0.32 ethionamide Not assoc w R - Interim
Rv0565c 656226 c.1243_1245delGCCinsTT frameshift_variant&missense_variant 0.32 ethionamide Uncertain significance
Rv0565c 656238 p.Ala411Glu missense_variant 0.34 ethionamide
Rv0565c 656243 p.Leu410Met missense_variant 0.34 ethionamide
Rv0565c 656244 c.1227A>C synonymous_variant 0.34 ethionamide
Rv0565c 656265 c.1206G>C synonymous_variant 0.35 ethionamide
Rv0565c 656268 p.Met401Ile missense_variant 0.34 ethionamide
Rv0565c 656277 c.1194C>G synonymous_variant 0.34 ethionamide
Rv0565c 656289 c.1182C>G synonymous_variant 0.29 ethionamide
Rv0565c 656298 c.1173G>C synonymous_variant 0.25 ethionamide
Rv0565c 656304 c.1167T>C synonymous_variant 0.24 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.26 ethionamide
hadA 731682 c.-248C>G upstream_gene_variant 0.34 isoniazid
hadA 731687 c.-243_-242insCACAGATCTTTT upstream_gene_variant 0.33 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 0.35 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.35 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.35 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.34 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.33 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.4 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.47 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.47 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.37 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.34 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.34 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.3 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.27 isoniazid
hadA 731840 c.-90G>C upstream_gene_variant 0.24 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.23 isoniazid
hadA 731849 c.-81C>T upstream_gene_variant 0.24 isoniazid
hadA 731852 c.-78A>G upstream_gene_variant 0.24 isoniazid
hadA 732268 c.339T>G synonymous_variant 0.2 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.38 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.39 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.42 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.41 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.45 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.5 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.53 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.57 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.57 isoniazid
nusG 734370 c.117A>G synonymous_variant 0.2 rifampicin
nusG 734376 c.123G>A synonymous_variant 0.21 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.33 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.36 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.34 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.42 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.44 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.45 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.45 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.35 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.34 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.25 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.24 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.23 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.27 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.26 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.28 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.36 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.45 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.47 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.5 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.51 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.49 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.5 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.48 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.46 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.42 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.36 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.39 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.39 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.32 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.3 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.27 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.26 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.28 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.28 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.26 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.25 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.19 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.28 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.41 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.46 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760949 c.1143C>T synonymous_variant 0.46 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.57 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.57 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.37 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.31 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.32 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.31 rifampicin
rpoB 761373 p.Val523His missense_variant 0.28 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.21 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.23 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.23 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.28 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.46 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.47 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761639 c.1833G>A synonymous_variant 0.54 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.52 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761948 c.2142G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.29 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.29 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.29 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.3 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.3 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.37 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.36 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.41 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.42 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.44 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.46 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.39 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.37 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.37 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.38 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.32 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.31 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.31 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.33 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.2 rifampicin
rpoC 762582 c.-788T>C upstream_gene_variant 0.2 rifampicin
rpoC 762758 c.-612G>C upstream_gene_variant 0.76 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.76 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.74 rifampicin Uncertain significance
rpoC 762794 c.-576C>G upstream_gene_variant 0.73 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.74 rifampicin Uncertain significance
rpoB 762810 c.3004_3006delGCCinsTG frameshift_variant&missense_variant 0.65 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.64 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.44 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.49 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.54 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.56 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.56 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.5 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.44 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.44 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.44 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.45 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.36 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.36 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763283 c.3477T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763284 c.-86C>T upstream_gene_variant 0.22 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.38 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.43 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.51 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.55 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.39 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.5 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.54 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.56 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.56 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.58 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.62 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.61 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.58 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.62 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.62 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.57 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.62 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.59 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.63 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.56 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.55 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.55 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.57 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.6 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.61 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764112 p.Tyr248Phe missense_variant 0.64 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.64 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.6 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.61 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.64 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.63 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.59 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.58 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.59 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.59 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.38 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.38 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.28 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.27 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.29 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.49 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.57 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.59 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.62 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.66 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.55 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.55 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.42 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.44 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.45 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.46 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.38 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.34 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.3 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.3 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.7 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.72 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.71 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.67 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.63 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.63 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.63 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.63 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.61 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.6 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.64 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.63 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.63 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.64 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.62 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.63 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.64 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.64 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.65 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.66 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.74 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.76 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.82 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.83 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.83 rifampicin
rpoC 766036 c.2667C>T synonymous_variant 0.83 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.84 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.88 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.72 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.73 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.49 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.38 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766168 c.2799C>T synonymous_variant 0.21 rifampicin
rpoC 766288 c.2919C>G synonymous_variant 0.33 rifampicin
rpoC 766303 c.2934C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.51 rifampicin
rpoC 766327 c.2958C>A synonymous_variant 0.54 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.57 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.6 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.62 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.67 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.67 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.73 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.74 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.79 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.63 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.54 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.4 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.38 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.36 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.4 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.35 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.32 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.3 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.29 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.3 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.28 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.33 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.34 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.38 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.34 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.35 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.32 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.32 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.39 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.41 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.38 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.37 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.57 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.57 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.62 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.65 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.6 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.54 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.47 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776182 p.Asp767Asn missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.22 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.29 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.27 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.28 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.42 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.45 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.49 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.5 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.58 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.57 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.59 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.6 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.58 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.59 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.59 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.6 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.62 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.61 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.65 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.65 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.61 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.59 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.6 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.57 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.57 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.57 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.56 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.58 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.6 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.59 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.6 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.23 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.26 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.27 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.29 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.33 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.33 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.4 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.44 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.44 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.5 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.47 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.5 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.51 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.5 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.51 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.52 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.48 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.5 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.39 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.4 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.42 linezolid
rplC 800814 c.6A>G synonymous_variant 0.43 linezolid
rplC 800817 c.9A>T synonymous_variant 0.43 linezolid
rplC 800844 c.36T>C synonymous_variant 0.4 linezolid
rplC 800865 c.57A>G synonymous_variant 0.37 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.36 linezolid
rplC 800874 c.66A>G synonymous_variant 0.32 linezolid
rplC 800875 c.67_69delGTAinsAT frameshift_variant&missense_variant 0.3 linezolid
rplC 800880 c.72A>G synonymous_variant 0.3 linezolid
rplC 800889 c.81C>G synonymous_variant 0.33 linezolid
rplC 800892 c.84G>C synonymous_variant 0.32 linezolid
rplC 800907 c.99C>G synonymous_variant 0.3 linezolid
rplC 800916 c.108A>G synonymous_variant 0.24 linezolid
rplC 801282 c.474G>C synonymous_variant 0.51 linezolid
rplC 801285 c.477G>C synonymous_variant 0.5 linezolid
rplC 801300 c.492C>G synonymous_variant 0.51 linezolid
rplC 801309 c.501C>G synonymous_variant 0.47 linezolid
rplC 801312 c.504G>C synonymous_variant 0.51 linezolid
rplC 801321 c.513C>T synonymous_variant 0.52 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.53 linezolid
rplC 801339 c.531T>C synonymous_variant 0.49 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.49 linezolid
rplC 801348 c.540T>G synonymous_variant 0.48 linezolid
rplC 801357 c.549T>C synonymous_variant 0.46 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.45 linezolid
rplC 801402 c.594T>C synonymous_variant 0.45 linezolid
rplC 801405 c.597T>C synonymous_variant 0.45 linezolid
rplC 801423 c.615G>C synonymous_variant 0.45 linezolid
rplC 801426 c.618C>G synonymous_variant 0.46 linezolid
rplC 801427 p.Met207Val missense_variant 0.47 linezolid
rplC 801438 c.630T>C synonymous_variant 0.46 linezolid
rplC 801442 p.Ile212Val missense_variant 0.52 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1304499 c.1569T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304511 c.1581C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304535 c.1605G>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
atpE 1460816 c.-229T>C upstream_gene_variant 0.22 bedaquiline
atpE 1460831 c.-214T>C upstream_gene_variant 0.25 bedaquiline
atpE 1460840 c.-205A>G upstream_gene_variant 0.25 bedaquiline
atpE 1460852 c.-193C>G upstream_gene_variant 0.28 bedaquiline
atpE 1460855 c.-190T>C upstream_gene_variant 0.27 bedaquiline
atpE 1460858 c.-187C>G upstream_gene_variant 0.26 bedaquiline
atpE 1460861 c.-184C>G upstream_gene_variant 0.26 bedaquiline
atpE 1460882 c.-163T>C upstream_gene_variant 0.24 bedaquiline
atpE 1460894 c.-151A>G upstream_gene_variant 0.21 bedaquiline
atpE 1460897 c.-148A>C upstream_gene_variant 0.21 bedaquiline
atpE 1460900 c.-145T>C upstream_gene_variant 0.2 bedaquiline
atpE 1460915 c.-130C>G upstream_gene_variant 0.2 bedaquiline
atpE 1460918 c.-127A>G upstream_gene_variant 0.2 bedaquiline
atpE 1461089 c.45G>C synonymous_variant 0.22 bedaquiline
atpE 1461097 p.Ala18Gly missense_variant 0.25 bedaquiline
atpE 1461101 c.57T>C synonymous_variant 0.27 bedaquiline
atpE 1461107 c.63C>G synonymous_variant 0.28 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.34 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.37 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.39 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.38 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.38 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.38 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.38 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.36 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.38 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.4 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.33 bedaquiline
atpE 1461251 c.207G>C synonymous_variant 0.24 bedaquiline
atpE 1461254 c.210T>C synonymous_variant 0.22 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474409 n.756_766delACCCACACGCG non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1474429 n.772G>C non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1474431 n.774_775delGCinsTTTGGG non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1474435 n.780_783delGAAT non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.61 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.58 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.43 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.39 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674480 c.279T>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674504 c.303C>G synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.31 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674552 c.351C>G synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.26 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.31 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.29 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674672 c.471C>G synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674723 c.522C>T synonymous_variant 0.29 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674801 c.600T>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.45 ethionamide
isoniazid
inhA 1674855 c.654C>G synonymous_variant 0.55 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674864 c.663C>T synonymous_variant 0.5 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.52 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.43 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.42 ethionamide
isoniazid
inhA 1674909 c.708G>A synonymous_variant 0.42 ethionamide
isoniazid
inhA 1674942 c.741T>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674960 c.759C>G synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674966 c.765T>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674967 p.Asp256Thr missense_variant 0.22 ethionamide
isoniazid
rpsA 1833532 c.-10A>C upstream_gene_variant 0.34 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.41 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.47 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.48 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.56 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.58 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.61 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.58 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.58 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.62 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.57 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.57 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.6 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.6 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.58 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.57 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.55 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.55 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.53 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.48 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.48 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.51 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.52 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.49 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.41 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.39 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.99 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.39 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834654 p.Glu371Asp missense_variant 0.22 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.45 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.45 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.5 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.46 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.45 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.42 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.39 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.49 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.45 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.48 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.49 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.37 linezolid
tsnR 1853423 c.-183C>T upstream_gene_variant 0.37 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.36 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.38 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
bacA 2064892 c.-164A>G upstream_gene_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064897 c.-169C>G upstream_gene_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064903 c.-175G>A upstream_gene_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064912 c.-184A>G upstream_gene_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064915 c.-187G>C upstream_gene_variant 0.32 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064933 c.-205A>G upstream_gene_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064936 c.-208C>G upstream_gene_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064942 c.-214G>A upstream_gene_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.36 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.44 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.41 streptomycin
kanamycin
capreomycin
amikacin
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.56 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.44 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.41 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.31 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.25 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.24 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.27 isoniazid
kasA 2518146 p.Phe11Tyr missense_variant 0.26 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.25 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.25 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.26 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.26 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.24 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.23 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.24 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.21 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.2 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.19 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.32 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.31 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.29 isoniazid
Rv2477c 2783182 c.861C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.48 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.54 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.54 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.65 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.63 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.61 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.58 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.47 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2752c 3065946 p.Gly82Ala missense_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065955 c.235_237delTTGinsCC frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065979 c.213T>C synonymous_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065993 p.Val67Ile missense_variant 0.31 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066002 p.Met64Leu missense_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066009 c.183G>C synonymous_variant 0.42 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066018 c.174T>C synonymous_variant 0.42 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>G synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066040 p.Gly51Thr missense_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066042 c.150T>C synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066045 c.147T>C synonymous_variant 0.39 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.41 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.4 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066102 c.90C>T synonymous_variant 0.38 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066118 p.Asn25Ser missense_variant 0.36 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067549 p.Thr133Ala missense_variant 0.71 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.61 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.63 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.57 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.55 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.57 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.5 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.45 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 0.25 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.25 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.27 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073923 c.547_549delTTGinsCA frameshift_variant&missense_variant 0.28 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073947 c.525G>A synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074028 c.444G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.21 para-aminosalicylic_acid
thyA 3074055 p.Glu139Pro missense_variant 0.21 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074079 c.393G>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074100 c.370_372delGATinsAC frameshift_variant&synonymous_variant 0.35 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.32 para-aminosalicylic_acid
thyA 3074163 c.307_309delGCTinsAG frameshift_variant&missense_variant 0.32 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.34 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.33 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.32 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.29 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3624077 c.834G>A synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624082 c.829A>C synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624092 p.Arg273Ser missense_variant 0.19 bedaquiline
rifampicin
lpqB 3624101 c.810C>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624143 c.768T>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624166 p.Met249Leu missense_variant 0.21 bedaquiline
rifampicin
lpqB 3624167 c.744C>T synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624173 c.738A>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624179 c.732C>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624185 c.726C>T synonymous_variant 0.22 bedaquiline
rifampicin
mtrB 3625837 c.777C>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626704 c.-91C>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.32 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.46 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.48 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.48 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.41 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrA 3627343 p.Thr3Ser missense_variant 0.33 bedaquiline
rifampicin
mtrB 3627360 c.-747G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.21 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.34 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.36 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.5 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.47 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.47 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.41 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.3 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.47 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.51 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.51 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.51 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.54 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.55 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.54 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.55 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.52 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877969 p.Ala180Val missense_variant 0.46 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.53 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.43 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.42 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.42 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.42 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.4 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.39 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.37 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.36 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.35 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.36 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878094 c.414C>G synonymous_variant 0.34 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.33 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.34 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.32 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.31 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.34 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.42 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.45 rifampicin
rpoA 3878181 c.327C>T synonymous_variant 0.49 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.49 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.47 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.51 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.51 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.53 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.55 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.55 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.5 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.51 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.49 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.5 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.51 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.49 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.48 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.49 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.43 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.41 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.4 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.4 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.37 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.37 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.37 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.42 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.42 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.38 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.22 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.21 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.21 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.32 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.3 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.29 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.38 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.42 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.42 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.46 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.45 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.45 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.43 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.45 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.42 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.44 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.49 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.51 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.49 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.52 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.47 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.45 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.43 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.34 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.34 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.22 rifampicin
clpC1 4038530 p.Glu725Asp missense_variant 0.29 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.43 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.52 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.55 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.56 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.53 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.53 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.51 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.55 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.54 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.52 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.51 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.52 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.52 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.58 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.56 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.58 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.58 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.57 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.6 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.59 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.61 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.6 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.59 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.57 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.54 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.54 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.53 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.51 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.49 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.49 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.3 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.32 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039988 c.717C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.26 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040501 c.204C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
panD 4044635 c.-354G>C upstream_gene_variant 0.6 pyrazinamide
panD 4044643 c.-362G>T upstream_gene_variant 0.6 pyrazinamide
panD 4044647 c.-366C>G upstream_gene_variant 0.6 pyrazinamide
panD 4044650 c.-369G>C upstream_gene_variant 0.6 pyrazinamide
panD 4044662 c.-381C>G upstream_gene_variant 0.5 pyrazinamide
panD 4044668 c.-387G>C upstream_gene_variant 0.5 pyrazinamide
panD 4044672 c.-392_-391delGCinsCA upstream_gene_variant 0.52 pyrazinamide
panD 4044675 c.-394T>C upstream_gene_variant 0.48 pyrazinamide
panD 4044677 c.-396T>C upstream_gene_variant 0.48 pyrazinamide
panD 4044682 c.-401C>A upstream_gene_variant 0.5 pyrazinamide
panD 4044688 c.-407T>C upstream_gene_variant 0.5 pyrazinamide
panD 4044692 c.-411G>C upstream_gene_variant 0.51 pyrazinamide
panD 4044700 c.-419C>A upstream_gene_variant 0.53 pyrazinamide
panD 4044704 c.-423G>C upstream_gene_variant 0.49 pyrazinamide
panD 4044712 c.-431C>A upstream_gene_variant 0.47 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.42 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.44 pyrazinamide
panD 4044746 c.-467_-465delGTGinsAC upstream_gene_variant 0.36 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.4 pyrazinamide
panD 4044917 c.-636G>C upstream_gene_variant 0.23 pyrazinamide
panD 4044926 c.-645C>A upstream_gene_variant 0.25 pyrazinamide
panD 4044929 c.-648G>C upstream_gene_variant 0.26 pyrazinamide
panD 4044935 c.-655_-654delAAinsTG upstream_gene_variant 0.25 pyrazinamide
panD 4044941 c.-660G>C upstream_gene_variant 0.26 pyrazinamide
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 0.24 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.27 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.26 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.25 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.23 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.23 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.22 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.21 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.2 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.2 pyrazinamide
glpK 4138418 c.1338T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138424 c.1332T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138429 c.1327T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138451 c.1305T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138460 c.1296C>T synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138463 c.1293C>A synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138472 c.1284G>T synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138478 c.1278T>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138481 c.1275G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138490 c.1266G>T synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138495 p.Gln421Glu missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138496 c.1260G>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138502 c.1254T>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138511 c.1245C>T synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138514 c.1242A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138517 p.Glu413Ala missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138523 c.1233C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138529 c.1227G>A synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138565 c.1191G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138574 c.1182G>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138580 c.1176C>T synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138598 c.1158G>A synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138607 c.1149G>A synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138610 c.1146C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138622 c.1134C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>C synonymous_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138646 c.1110G>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.38 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.36 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.34 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139588 c.168G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139601 p.Arg52Gln missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139615 c.141G>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139651 c.103_105delCACinsGG frameshift_variant&missense_variant 0.22 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139675 c.81C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240726 c.864G>C synonymous_variant 0.47 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.5 ethambutol
embC 4240781 c.919_921delGCGinsTC frameshift_variant&missense_variant 0.5 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.53 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.58 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.59 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.55 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.45 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.45 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.45 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.39 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.38 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.37 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.32 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.32 ethambutol
embC 4240903 c.1041C>G synonymous_variant 0.32 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.33 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.35 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.31 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.23 ethambutol
embC 4240996 c.1134G>C synonymous_variant 0.21 ethambutol
embC 4241002 c.1140G>C synonymous_variant 0.24 ethambutol
embC 4241013 p.Met384Thr missense_variant 0.25 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.33 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.42 ethambutol
embC 4241032 c.1170G>C synonymous_variant 0.45 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.45 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.62 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.71 ethambutol
embC 4241053 c.1191G>A synonymous_variant 0.82 ethambutol
embC 4241089 c.1227C>G synonymous_variant 1.0 ethambutol
embC 4241095 c.1233C>T synonymous_variant 1.0 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.43 ethambutol
embA 4242748 c.-485A>G upstream_gene_variant 0.22 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.19 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.24 ethambutol
embC 4242779 p.Asn973Asp missense_variant 0.2 ethambutol
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244582 c.1350T>C synonymous_variant 0.55 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.21 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.19 ethambutol
embA 4246088 c.2856A>G synonymous_variant 0.2 ethambutol Not assoc w R
embB 4246097 c.-417C>G upstream_gene_variant 0.2 ethambutol
embA 4246103 c.2871C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4246109 c.-405C>A upstream_gene_variant 0.2 ethambutol
embB 4246115 c.-399T>G upstream_gene_variant 0.2 ethambutol
embB 4246130 c.-384T>C upstream_gene_variant 0.21 ethambutol
embA 4246138 p.Arg969Gln missense_variant 0.21 ethambutol
embB 4246140 c.-374T>C upstream_gene_variant 0.21 ethambutol
embA 4246143 p.Ile971Val missense_variant 0.21 ethambutol
embB 4246157 c.-357A>G upstream_gene_variant 0.21 ethambutol
embA 4246164 c.2932T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4246184 c.-330A>C upstream_gene_variant 0.22 ethambutol
embB 4246196 c.-318C>G upstream_gene_variant 0.22 ethambutol
embB 4246205 c.-309A>G upstream_gene_variant 0.19 ethambutol
embB 4246211 c.-303T>C upstream_gene_variant 0.2 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.21 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.25 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.27 ethambutol
embB 4247407 c.894G>C synonymous_variant 0.28 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.33 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.35 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.36 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.34 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.41 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.4 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.45 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.48 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.53 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.54 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.54 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.5 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.51 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.54 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.53 ethambutol
embB 4247588 c.1075_1077delCTAinsAC frameshift_variant&missense_variant 0.54 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.6 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.56 ethambutol Not assoc w R - Interim
embB 4247614 c.1101T>C synonymous_variant 0.58 ethambutol Not assoc w R - Interim
embB 4247629 c.1116C>G synonymous_variant 0.59 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.24 ethambutol
embB 4247767 c.1254G>A synonymous_variant 0.26 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.26 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.27 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.33 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.35 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.28 ethambutol
embB 4248011 p.Ser500Arg missense_variant 0.23 ethambutol
embB 4248014 p.Thr501Ala missense_variant 0.22 ethambutol Uncertain significance
embB 4248027 p.Ala505Asp missense_variant 0.67 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.32 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.31 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.32 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.33 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.32 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.34 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.36 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.37 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.33 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.34 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.36 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.33 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.33 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.31 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.32 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.35 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.24 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.28 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.27 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.28 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.28 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.29 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.29 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.28 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.29 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.28 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.26 ethambutol
embB 4249594 c.3081G>C synonymous_variant 0.29 ethambutol
embB 4249606 c.3093C>A synonymous_variant 0.24 ethambutol
embB 4249609 c.3096T>C synonymous_variant 0.22 ethambutol
aftB 4267241 c.1596G>C synonymous_variant 0.22 ethambutol
aftB 4267244 c.1593T>C synonymous_variant 0.23 ethambutol
aftB 4267256 c.1581C>G synonymous_variant 0.24 ethambutol
aftB 4267262 c.1575T>C synonymous_variant 0.26 ethambutol
aftB 4267266 p.Ala524Gly missense_variant 0.25 ethambutol
aftB 4267268 c.1569T>C synonymous_variant 0.25 ethambutol
aftB 4267274 c.1563G>C synonymous_variant 0.25 ethambutol
aftB 4267289 p.Ala516Gln missense_variant 0.25 ethambutol
aftB 4267292 c.1545C>G synonymous_variant 0.24 ethambutol
aftB 4267297 c.1540T>C synonymous_variant 0.23 ethambutol
aftB 4267301 c.1536C>T synonymous_variant 0.22 ethambutol
aftB 4267304 p.Val511Ala missense_variant 0.22 ethambutol
aftB 4267316 c.1521A>G synonymous_variant 0.23 ethambutol
aftB 4267325 c.1512G>C synonymous_variant 0.25 ethambutol
aftB 4267334 c.1503T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 0.99 streptomycin Not assoc w R