TB-Profiler result

Run: SRR20969542
Summary

Run ID: SRR20969542

Sample name:

Date: 2024-10-05T05:03:51.884798

Number of reads: 5782149

Percentage reads mapped: 38.77

Median coverage: 162.0

Strain: lineage4.4.2

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.4 Euro-American None 1.0
lineage4.4.2 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin gyrA p.Asp94Tyr Assoc w R High-level resistance
ofloxacin
levofloxacin gyrA p.Asp94Tyr Assoc w R
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7581 p.Asp94Tyr missense_variant 0.91 levofloxacin Assoc w R
moxifloxacin Assoc w R High-level resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rpoB 760916 c.1110C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760928 c.1122G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.18 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760953 p.Ile383Val missense_variant 0.2 rifampicin
rpoB 760961 c.1155C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760964 c.1158C>T synonymous_variant 0.2 rifampicin
rpoB 760965 p.Met387Leu missense_variant 0.2 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.21 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762002 c.2196C>G synonymous_variant 0.12 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762084 p.Ala760Pro missense_variant 0.13 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.15 rifampicin Uncertain significance
rpoB 762117 c.2311_2312delTCinsAG synonymous_variant 0.15 rifampicin
rpoB 762122 p.Asp772Glu missense_variant 0.14 rifampicin
rpoB 762126 p.Val774Met missense_variant 0.14 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.14 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.14 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762156 p.Val784Ile missense_variant 0.14 rifampicin
rpoB 762161 c.2355C>G synonymous_variant 0.14 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762178 p.Arg791Pro missense_variant 0.12 rifampicin
rpoB 762179 c.2374_2375delGA frameshift_variant 0.13 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.13 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762920 c.-450C>G upstream_gene_variant 0.21 rifampicin
rpoB 762923 c.3117C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.23 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.3 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763022 c.-348C>G upstream_gene_variant 0.38 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.38 rifampicin Not assoc w R
rpoB 763038 p.Thr1078Ala missense_variant 0.39 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.32 rifampicin
rpoB 763077 p.Val1091Leu missense_variant 0.32 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.24 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.13 rifampicin
rpoC 763442 p.Tyr25His missense_variant 0.13 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763462 c.93G>C synonymous_variant 0.22 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.3 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763504 c.135C>G synonymous_variant 0.34 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.35 rifampicin
rpoC 763528 c.159G>T synonymous_variant 0.36 rifampicin
rpoC 763532 p.Thr55Gln missense_variant 0.35 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.37 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763622 p.Ala85Ser missense_variant 0.42 rifampicin Uncertain significance
rpoC 763630 c.261G>T synonymous_variant 0.39 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>G synonymous_variant 0.38 rifampicin
rpoC 763648 c.279C>T synonymous_variant 0.35 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>T synonymous_variant 0.3 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763672 c.303C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.22 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763729 c.360G>C synonymous_variant 0.22 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.14 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.12 rifampicin
rpoC 764326 c.957G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764338 p.Glu323Asp missense_variant 0.16 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.23 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764404 c.1035C>G synonymous_variant 0.27 rifampicin
rpoC 764405 c.1036_1038delAGGinsCGT synonymous_variant 0.27 rifampicin
rpoC 764419 c.1050C>G synonymous_variant 0.3 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.31 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.31 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764491 c.1122G>C synonymous_variant 0.35 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.32 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.34 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>T synonymous_variant 0.37 rifampicin
rpoC 764536 c.1167G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>C synonymous_variant 0.36 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.37 rifampicin
rpoC 764560 c.1191T>G synonymous_variant 0.36 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.36 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.36 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.39 rifampicin
rpoC 764623 c.1254C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764672 p.Gln435Lys missense_variant 0.39 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.38 rifampicin
rpoC 764706 p.Leu446Gln missense_variant 0.38 rifampicin Uncertain significance
rpoC 764752 c.1383G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.29 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.27 rifampicin
rpoC 764803 c.1434C>G synonymous_variant 0.26 rifampicin
rpoC 764809 c.1440C>G synonymous_variant 0.21 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.19 rifampicin
rpoC 764813 p.Gln482Val missense_variant 0.19 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.19 rifampicin
rpoC 764844 p.Ala492Gly missense_variant 0.19 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.16 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472225 n.380C>G non_coding_transcript_exon_variant 0.59 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.42 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472298 n.453_468delGTCCGGGTTCTCTCGGinsCGTA non_coding_transcript_exon_variant 0.42 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472370 n.525T>G non_coding_transcript_exon_variant 0.4 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472396 n.551A>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472425 n.580T>C non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472437 n.592T>A non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472439 n.594C>T non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.13 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.13 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472467 n.622G>C non_coding_transcript_exon_variant 0.15 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 0.2 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472486 n.641A>G non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472494 n.649A>T non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472583 n.738T>A non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472647 n.802C>T non_coding_transcript_exon_variant 0.55 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.4 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472674 n.829T>G non_coding_transcript_exon_variant 0.41 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472675 n.830T>G non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472678 n.833_834insC non_coding_transcript_exon_variant 0.41 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472681 n.837_839delTTG non_coding_transcript_exon_variant 0.41 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472690 n.845_846insCT non_coding_transcript_exon_variant 0.41 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>G non_coding_transcript_exon_variant 0.48 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>C non_coding_transcript_exon_variant 0.49 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.49 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472991 n.1146G>A non_coding_transcript_exon_variant 0.49 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.55 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473262 n.1417T>C non_coding_transcript_exon_variant 0.54 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.46 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473314 n.1469A>G non_coding_transcript_exon_variant 0.39 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1474143 n.486T>C non_coding_transcript_exon_variant 0.12 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474155 n.498G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474265 n.608G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474287 n.631_640delCCTTTTCCTC non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474299 n.642C>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474302 n.646_653delAGGAGGGT non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474381 n.724T>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474476 n.819C>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474483 n.826C>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474488 n.831G>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474516 n.859C>G non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474528 n.871T>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474530 n.873G>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474541 n.884G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474558 n.901G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474825 n.1168G>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474869 n.1212G>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474901 n.1244A>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404delCinsAAG non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475065 n.1409_1411delCAA non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475076 n.1419_1424delCCTTGCinsACCCTT non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475154 n.1497C>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475482 n.1825A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475485 n.1828_1829delCAinsG non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475542 n.1885A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475571 n.1914A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475586 n.1929C>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475688 n.2031G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475696 n.2039T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475697 n.2040C>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475702 n.2045G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475703 n.2046A>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475713 n.2056C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475740 n.2083G>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475747 n.2090A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475781 n.2124T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1475788 n.2131C>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476126 n.2469C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.56 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.69 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.67 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.64 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476528 n.2871A>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.48 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.12 capreomycin Uncertain significance
linezolid
rpsA 1833926 p.Thr129Ser missense_variant 0.15 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.25 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.35 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.36 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834009 c.468C>G synonymous_variant 0.39 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.38 pyrazinamide
rpsA 1834018 c.477C>T synonymous_variant 0.39 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.39 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.39 pyrazinamide
rpsA 1834040 p.Lys167Arg missense_variant 0.38 pyrazinamide
rpsA 1834046 p.Ile169Leu missense_variant 0.38 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.38 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.32 pyrazinamide
rpsA 1834105 c.564C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834140 p.Ser200Thr missense_variant 0.24 pyrazinamide
rpsA 1834150 c.609G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834156 p.Asn205Lys missense_variant 0.17 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834164 c.623_624insGGGGC frameshift_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834167 c.627_631delCACCA frameshift_variant 0.18 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834183 c.642T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834241 c.700C>T synonymous_variant 0.13 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.23 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.23 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834307 p.Asp256Gln missense_variant 0.23 pyrazinamide
rpsA 1834316 p.Thr259Glu missense_variant 0.23 pyrazinamide
rpsA 1834327 c.786G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834330 c.789C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.31 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834378 c.837T>G synonymous_variant 0.33 pyrazinamide
rpsA 1834384 c.843A>G synonymous_variant 0.35 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.32 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.33 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834421 p.Gly294Gln missense_variant 0.25 pyrazinamide
rpsA 1834438 c.897C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834451 c.910T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.25 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.22 pyrazinamide
rpsA 1834477 c.936C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834480 c.939C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834483 p.Glu314Asp missense_variant 0.17 pyrazinamide
rpsA 1834486 p.Glu315Asp missense_variant 0.18 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.12 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
PPE35 2170067 c.546C>T synonymous_variant 1.0 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
ahpC 2725978 c.-215G>A upstream_gene_variant 0.98 isoniazid
Rv2752c 3066099 p.Met31Ile missense_variant 0.99 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 0.99 rifampicin Not assoc w R
bedaquiline Uncertain significance
clpC1 4039037 c.1668T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039153 p.Ile518Val missense_variant 0.32 pyrazinamide
clpC1 4039154 c.1551G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.28 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039190 p.Thr505Ser missense_variant 0.2 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.2 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039215 p.Phe497Tyr missense_variant 0.2 pyrazinamide
clpC1 4039217 c.1488G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039533 p.Asn391Ser missense_variant 0.23 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039550 c.1155G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.28 pyrazinamide Uncertain significance
clpC1 4039571 c.1134G>A synonymous_variant 0.28 pyrazinamide
clpC1 4039574 c.1131G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039646 p.Glu353Ala missense_variant 0.29 pyrazinamide
clpC1 4039651 p.Val352Leu missense_variant 0.27 pyrazinamide
clpC1 4039654 p.Thr351Ser missense_variant 0.27 pyrazinamide
clpC1 4039670 p.Val345Ile missense_variant 0.26 pyrazinamide
clpC1 4039682 c.1023C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039694 c.1011G>T synonymous_variant 0.28 pyrazinamide
clpC1 4039709 p.Ile332Leu missense_variant 0.27 pyrazinamide
clpC1 4039714 p.Tyr331His missense_variant 0.27 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039766 c.939T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039773 p.Lys311Met missense_variant 0.2 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.18 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.16 pyrazinamide
clpC1 4039838 p.Leu289Ile missense_variant 0.14 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039875 p.Asn277Arg missense_variant 0.15 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.12 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.12 pyrazinamide
clpC1 4039930 p.Ser259Cys missense_variant 0.12 pyrazinamide
clpC1 4039943 p.Ser254Ala missense_variant 0.12 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.17 pyrazinamide
embC 4238963 c.-900C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 0.99 ethambutol Not assoc w R
embA 4246508 c.3276G>A synonymous_variant 0.99 ethambutol Not assoc w R
ubiA 4268928 c.906C>T synonymous_variant 0.99 ethambutol Not assoc w R
ubiA 4269375 c.459G>A synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin