TB-Profiler result

Run: SRR10993951
Summary

Run ID: SRR10993951

Sample name:

Date: 02-04-2023 19:49:07

Number of reads: 735854

Percentage reads mapped: 47.79

Strain: La1.6

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
La1 M.bovis None None 1.0
La1.6 M.bovis None None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761127 p.Ser441Ala missense_variant 0.33 rifampicin
rpoB 761196 p.Leu464Met missense_variant 0.35 rifampicin
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.7 streptomycin
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.67 kanamycin, capreomycin, aminoglycosides, amikacin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.58 kanamycin, capreomycin, aminoglycosides, amikacin
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5752 c.513G>A synonymous_variant 1.0
gyrA 6406 c.-896C>T upstream_gene_variant 1.0
gyrB 6446 p.Ala403Ser missense_variant 1.0
gyrA 7042 c.-260C>T upstream_gene_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8285 c.984C>T synonymous_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 1.0
gyrA 9217 p.Asp639Ala missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 761015 c.1209G>C synonymous_variant 0.15
rpoB 761027 c.1221A>G synonymous_variant 0.18
rpoB 761037 c.1231_1233delTTGinsCTC synonymous_variant 0.2
rpoB 761051 c.1245G>T synonymous_variant 0.25
rpoB 761054 c.1248G>T synonymous_variant 0.26
rpoB 761057 c.1251G>C synonymous_variant 0.26
rpoB 761060 c.1254C>G synonymous_variant 0.26
rpoB 761084 c.1278C>A synonymous_variant 0.3
rpoB 761088 c.1282_1284delAGCinsTCG synonymous_variant 0.29
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.26
rpoB 761102 c.1296A>G synonymous_variant 0.26
rpoB 761111 c.1305C>T synonymous_variant 0.33
rpoB 761126 c.1320G>C synonymous_variant 0.33
rpoB 761132 c.1326G>T synonymous_variant 0.33
rpoB 761133 c.1327T>C synonymous_variant 0.33
rpoB 761147 c.1341C>T synonymous_variant 0.33
rpoB 761150 c.1344A>C synonymous_variant 0.33
rpoB 761156 c.1350G>T synonymous_variant 0.33
rpoB 761165 c.1359G>C synonymous_variant 0.33
rpoB 761171 c.1365C>T synonymous_variant 0.33
rpoB 761177 c.1371G>C synonymous_variant 0.33
rpoB 761180 c.1374A>C synonymous_variant 0.33
rpoB 761183 c.1377T>C synonymous_variant 0.36
rpoB 761186 p.Glu460Asp missense_variant 0.36
rpoB 761189 c.1383T>C synonymous_variant 0.36
rpoB 761194 p.Gly463Ala missense_variant 0.35
rpoB 761207 c.1401C>T synonymous_variant 0.34
rpoB 761213 c.1407G>C synonymous_variant 0.34
rpoB 761234 c.1428G>C synonymous_variant 0.34
rpoB 761249 c.1443A>G synonymous_variant 0.34
rpoB 761255 c.1449T>C synonymous_variant 0.26
rpoB 761258 c.1452G>A synonymous_variant 0.26
rpoB 761261 c.1455G>T synonymous_variant 0.26
rpoB 761264 c.1458C>G synonymous_variant 0.26
rpoB 761276 c.1470G>C synonymous_variant 0.24
rpoB 761282 c.1476C>T synonymous_variant 0.2
rpoB 761288 c.1482G>C synonymous_variant 0.17
rpoB 761289 p.Ser495Ala missense_variant 0.15
rpoB 761292 p.Val496Ser missense_variant 0.15
rpoB 761304 p.Val500Ile missense_variant 0.17
rpoB 761318 c.1512G>C synonymous_variant 0.13
rpoB 762053 c.2247T>C synonymous_variant 0.17
rpoB 762057 p.Ile751Val missense_variant 0.17
rpoB 762062 c.2256T>C synonymous_variant 0.18
rpoB 762065 c.2259T>C synonymous_variant 0.19
rpoB 762080 c.2274G>C synonymous_variant 0.19
rpoB 762086 c.2280G>C synonymous_variant 0.19
rpoB 762101 c.2295C>G synonymous_variant 0.21
rpoB 762119 c.2313C>G synonymous_variant 0.19
rpoB 762120 p.Asp772Pro missense_variant 0.19
rpoB 762125 p.Glu773Asp missense_variant 0.19
rpoB 762127 p.Val774Ala missense_variant 0.19
rpoB 762131 c.2325C>G synonymous_variant 0.19
rpoB 762140 c.2334G>C synonymous_variant 0.19
rpoB 762143 c.2337T>C synonymous_variant 0.19
rpoB 762146 p.Glu780Asp missense_variant 0.19
rpoB 762149 c.2343G>C synonymous_variant 0.2
rpoB 762156 p.Val784Ile missense_variant 0.21
rpoB 762167 c.2361T>C synonymous_variant 0.2
rpoB 762176 c.2370T>C synonymous_variant 0.2
rpoB 762177 p.Arg791Thr missense_variant 0.2
rpoB 762185 c.2379G>C synonymous_variant 0.2
rpoB 762194 c.2388G>C synonymous_variant 0.2
rpoB 762233 c.2427G>C synonymous_variant 0.17
rpoB 762245 c.2439G>T synonymous_variant 0.12
rpoB 762251 c.2445G>C synonymous_variant 0.12
rpoB 762878 p.Ile1024Met missense_variant 0.18
rpoB 762879 p.Met1025Leu missense_variant 0.18
rpoC 762887 c.-483G>C upstream_gene_variant 0.2
rpoC 762896 c.-474G>C upstream_gene_variant 0.21
rpoC 762899 c.-471G>C upstream_gene_variant 0.2
rpoC 762911 c.-459C>T upstream_gene_variant 0.27
rpoC 762917 c.-453C>G upstream_gene_variant 0.29
rpoC 762923 c.-447C>G upstream_gene_variant 0.31
rpoC 762929 c.-441G>T upstream_gene_variant 0.33
rpoC 762959 c.-411G>C upstream_gene_variant 0.4
rpoC 762980 c.-390T>C upstream_gene_variant 0.36
rpoC 762983 c.-387C>T upstream_gene_variant 0.36
rpoC 762989 c.-381G>C upstream_gene_variant 0.36
rpoC 762995 c.-375G>T upstream_gene_variant 0.36
rpoB 763002 c.3197dupA frameshift_variant 0.39
rpoB 763006 c.3201delC frameshift_variant 0.4
rpoB 763014 p.Met1070Leu missense_variant 0.44
rpoB 763017 p.Gln1071Glu missense_variant 0.41
rpoC 763031 c.-339T>G upstream_gene_variant 1.0
rpoC 763034 c.-336C>G upstream_gene_variant 0.39
rpoC 763040 c.-330C>G upstream_gene_variant 0.41
rpoC 763053 c.-317T>C upstream_gene_variant 0.4
rpoC 763058 c.-312C>G upstream_gene_variant 0.37
rpoC 763085 c.-285C>T upstream_gene_variant 0.35
rpoC 763094 c.-276G>C upstream_gene_variant 0.35
rpoC 763100 c.-270G>A upstream_gene_variant 0.35
rpoC 763103 c.-267G>C upstream_gene_variant 0.35
rpoB 763122 p.Ile1106Leu missense_variant 0.26
rpoC 763127 c.-243G>C upstream_gene_variant 0.26
rpoB 763130 p.Glu1108Asp missense_variant 0.26
rpoC 763136 c.-234C>A upstream_gene_variant 0.28
rpoC 763157 c.-213G>C upstream_gene_variant 0.19
rpoC 763160 c.-210G>C upstream_gene_variant 0.17
rpoB 763161 p.Leu1119Ile missense_variant 0.17
rpoC 763166 c.-204A>G upstream_gene_variant 0.14
rpoC 763169 c.-201A>G upstream_gene_variant 0.14
rpoB 763170 p.Leu1122Met missense_variant 0.14
rpoC 763504 c.135C>A synonymous_variant 0.13
rpoC 763507 c.138G>C synonymous_variant 0.13
rpoC 763528 c.159G>C synonymous_variant 0.19
rpoC 763531 c.162G>C synonymous_variant 0.19
rpoC 763534 c.165T>C synonymous_variant 0.19
rpoC 763537 c.168C>T synonymous_variant 0.19
rpoC 763546 c.177A>G synonymous_variant 0.19
rpoC 763550 p.Tyr61Ala missense_variant 0.19
rpoC 763570 c.201G>C synonymous_variant 0.18
rpoC 763585 c.216C>G synonymous_variant 0.17
rpoC 763621 c.252C>T synonymous_variant 0.2
rpoC 763630 c.261G>A synonymous_variant 0.2
rpoC 763633 c.264T>C synonymous_variant 0.2
rpoC 763642 c.273G>C synonymous_variant 0.19
rpoC 763660 c.291T>C synonymous_variant 0.19
rpoC 763666 c.297G>T synonymous_variant 0.19
rpoC 763696 c.327T>C synonymous_variant 0.15
rpoC 763699 c.330G>T synonymous_variant 0.15
rpoC 763708 c.339G>C synonymous_variant 0.13
rpoC 763709 c.340C>T synonymous_variant 0.13
rpoC 763729 c.360G>C synonymous_variant 0.13
rpoC 763732 c.363C>G synonymous_variant 0.13
rpoC 763744 c.375G>C synonymous_variant 0.12
rpoC 764316 p.Ala316Val missense_variant 0.17
rpoC 764344 c.975C>T synonymous_variant 0.24
rpoC 764353 c.984G>C synonymous_variant 0.26
rpoC 764365 c.996C>T synonymous_variant 0.24
rpoC 764371 c.1002G>C synonymous_variant 0.23
rpoC 764377 c.1008C>G synonymous_variant 0.25
rpoC 764380 c.1011G>C synonymous_variant 0.23
rpoC 764383 c.1014C>G synonymous_variant 0.23
rpoC 764386 c.1017C>T synonymous_variant 0.22
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.22
rpoC 764395 c.1026C>T synonymous_variant 0.23
rpoC 764398 c.1029G>C synonymous_variant 0.21
rpoC 764404 c.1035C>T synonymous_variant 0.21
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.21
rpoC 764410 c.1041G>C synonymous_variant 0.22
rpoC 764428 c.1059G>C synonymous_variant 0.26
rpoC 764431 c.1062G>C synonymous_variant 0.25
rpoC 764434 c.1065A>G synonymous_variant 0.25
rpoC 764435 c.1066_1068delAGGinsCGC synonymous_variant 0.25
rpoC 764441 p.Ile358Leu missense_variant 0.24
rpoC 764446 c.1077T>C synonymous_variant 0.23
rpoC 764449 c.1080G>C synonymous_variant 0.23
rpoC 764455 c.1086G>T synonymous_variant 0.24
rpoC 764458 c.1089G>C synonymous_variant 0.22
rpoC 764461 c.1092A>G synonymous_variant 0.24
rpoC 764491 c.1122G>C synonymous_variant 0.36
rpoC 764498 p.Ser377Ala missense_variant 0.36
rpoC 764503 c.1134G>C synonymous_variant 0.33
rpoC 764507 p.Ala380Ser missense_variant 0.33
rpoC 764521 c.1152T>C synonymous_variant 0.32
rpoC 764524 c.1155C>T synonymous_variant 0.3
rpoC 764527 c.1158C>T synonymous_variant 0.3
rpoC 764533 c.1164C>T synonymous_variant 0.3
rpoC 764536 c.1167G>T synonymous_variant 0.3
rpoC 764539 c.1170C>G synonymous_variant 0.31
rpoC 764542 c.1173C>G synonymous_variant 0.32
rpoC 764548 c.1179G>A synonymous_variant 0.35
rpoC 764560 c.1191T>C synonymous_variant 0.35
rpoC 764575 c.1206T>G synonymous_variant 0.27
rpoC 764578 c.1209C>G synonymous_variant 0.26
rpoC 764581 c.1212T>C synonymous_variant 0.26
rpoC 764582 p.Leu405Met missense_variant 0.26
rpoC 764611 c.1242G>T synonymous_variant 0.31
rpoC 764632 c.1263T>C synonymous_variant 0.4
rpoC 764650 c.1281G>T synonymous_variant 0.43
rpoC 764662 c.1293G>C synonymous_variant 0.38
rpoC 764668 c.1299C>T synonymous_variant 0.38
rpoC 764679 p.Lys437Ser missense_variant 0.35
rpoC 764683 c.1314G>C synonymous_variant 0.35
rpoC 764690 p.Cys441Ala missense_variant 0.36
rpoC 764701 c.1332C>G synonymous_variant 0.36
rpoC 764705 p.Leu446Thr missense_variant 0.4
rpoC 764716 c.1347G>C synonymous_variant 0.4
rpoC 764737 c.1368G>C synonymous_variant 0.36
rpoC 764746 c.1377G>C synonymous_variant 0.37
rpoC 764752 c.1383G>C synonymous_variant 0.37
rpoC 764755 c.1386C>T synonymous_variant 0.41
rpoC 764764 c.1395T>C synonymous_variant 0.4
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.4
rpoC 764797 c.1428G>C synonymous_variant 0.37
rpoC 764803 c.1434C>T synonymous_variant 0.38
rpoC 764808 p.Arg480His missense_variant 0.38
rpoC 764812 c.1443C>G synonymous_variant 0.36
rpoC 764815 c.1446A>G synonymous_variant 0.35
rpoC 764824 c.1455T>C synonymous_variant 0.32
rpoC 764843 p.Ala492Thr missense_variant 0.3
rpoC 764848 c.1479G>A synonymous_variant 0.29
rpoC 764858 c.1489_1491delTTGinsCTC synonymous_variant 0.28
rpoC 764863 c.1494G>C synonymous_variant 0.27
rpoC 764875 c.1506C>G synonymous_variant 0.24
rpoC 764887 c.1518G>T synonymous_variant 0.15
rpoC 764888 c.1519T>C synonymous_variant 0.13
rpoC 764893 c.1524T>C synonymous_variant 0.13
rpoC 764911 c.1542A>G synonymous_variant 0.12
rpoC 764912 p.Met515Gln missense_variant 0.12
rpoC 764923 c.1554A>G synonymous_variant 0.12
rpoC 764935 c.1566T>C synonymous_variant 0.12
rpoC 764948 c.1579T>C synonymous_variant 0.12
rpoC 764956 c.1587T>C synonymous_variant 0.12
rpoC 764958 p.Glu530Ala missense_variant 0.12
rpoC 764968 c.1599T>C synonymous_variant 0.12
rpoC 764998 c.1629G>C synonymous_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0
fbiC 1305494 c.2565_*55delGGCCTAGCCCCGGCGACGATGCCGGGTCGCGGGATGCGGCCCGTTGAGGAGCGGGGCAATCT frameshift_variant&stop_lost&splice_region_variant 0.17
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472092 n.247C>T non_coding_transcript_exon_variant 0.16
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.17
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.17
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.17
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.17
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.2
rrs 1472120 n.275G>A non_coding_transcript_exon_variant 0.27
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.45
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.47
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.61
rrs 1472223 n.378C>G non_coding_transcript_exon_variant 0.7
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.71
rrs 1472228 n.383G>C non_coding_transcript_exon_variant 0.71
rrs 1472245 n.400C>A non_coding_transcript_exon_variant 0.71
rrs 1472251 n.406G>C non_coding_transcript_exon_variant 0.71
rrs 1472279 n.434T>G non_coding_transcript_exon_variant 0.7
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.69
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.7
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.7
rrs 1472293 n.448C>A non_coding_transcript_exon_variant 0.7
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.72
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.71
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.7
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 0.73
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.75
rrs 1472380 n.535G>A non_coding_transcript_exon_variant 0.76
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.73
rrs 1472427 n.582T>G non_coding_transcript_exon_variant 0.62
rrs 1472431 n.586G>A non_coding_transcript_exon_variant 0.61
rrs 1472434 n.589_590insC non_coding_transcript_exon_variant 0.6
rrs 1472437 n.592T>C non_coding_transcript_exon_variant 0.59
rrs 1472438 n.594delC non_coding_transcript_exon_variant 0.59
rrs 1472443 n.598A>G non_coding_transcript_exon_variant 0.59
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.59
rrs 1472448 n.603T>G non_coding_transcript_exon_variant 0.59
rrs 1472451 n.606C>A non_coding_transcript_exon_variant 0.58
rrs 1472452 n.607G>C non_coding_transcript_exon_variant 0.58
rrs 1472460 n.615T>G non_coding_transcript_exon_variant 0.57
rrs 1472461 n.616G>T non_coding_transcript_exon_variant 0.57
rrs 1472464 n.619A>C non_coding_transcript_exon_variant 0.57
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.57
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 0.56
rrs 1472474 n.629C>G non_coding_transcript_exon_variant 0.57
rrs 1472476 n.631A>G non_coding_transcript_exon_variant 0.58
rrs 1472484 n.639A>T non_coding_transcript_exon_variant 0.61
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.62
rrs 1472496 n.651T>A non_coding_transcript_exon_variant 0.62
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.63
rrs 1472506 n.661A>T non_coding_transcript_exon_variant 0.66
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.68
rrs 1472572 n.727T>A non_coding_transcript_exon_variant 0.71
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.71
rrs 1472591 n.746G>A non_coding_transcript_exon_variant 0.7
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.69
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.68
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.68
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.64
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.69
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.7
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.71
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.61
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.6
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.6
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.55
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.56
rrs 1472841 n.996G>A non_coding_transcript_exon_variant 0.56
rrs 1472845 n.1000G>C non_coding_transcript_exon_variant 0.55
rrs 1472846 n.1001C>G non_coding_transcript_exon_variant 0.54
rrs 1472848 n.1003T>C non_coding_transcript_exon_variant 0.54
rrs 1472851 n.1006A>G non_coding_transcript_exon_variant 0.54
rrs 1472854 n.1009G>A non_coding_transcript_exon_variant 0.55
rrs 1472856 n.1011T>C non_coding_transcript_exon_variant 0.56
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.56
rrs 1472861 n.1016G>C non_coding_transcript_exon_variant 0.56
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.56
rrs 1472874 n.1029C>T non_coding_transcript_exon_variant 0.56
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.59
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.64
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.68
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.71
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.7
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.7
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.71
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.72
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.69
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.67
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.65
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.66
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.72
rrs 1473047 n.1202C>T non_coding_transcript_exon_variant 0.72
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.72
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.72
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.74
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.75
rrs 1473091 n.1246G>A non_coding_transcript_exon_variant 0.72
rrs 1473093 n.1248C>A non_coding_transcript_exon_variant 0.73
rrs 1473094 n.1249T>A non_coding_transcript_exon_variant 0.73
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.72
rrs 1473100 n.1255G>C non_coding_transcript_exon_variant 0.72
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.72
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.71
rrs 1473111 n.1266A>C non_coding_transcript_exon_variant 0.71
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.71
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.73
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.75
rrs 1473147 n.1302G>T non_coding_transcript_exon_variant 0.74
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.74
rrs 1473157 n.1312C>T non_coding_transcript_exon_variant 0.76
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.74
rrs 1473164 n.1319C>A non_coding_transcript_exon_variant 0.74
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.66
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.61
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.54
rrs 1473298 n.1453A>G non_coding_transcript_exon_variant 0.56
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.57
rrs 1473305 n.1460G>T non_coding_transcript_exon_variant 0.57
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.57
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.57
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.57
rrl 1473658 n.1T>G non_coding_transcript_exon_variant 0.16
rrl 1473662 n.5A>G non_coding_transcript_exon_variant 0.16
rrl 1473668 n.11C>G non_coding_transcript_exon_variant 0.28
rrl 1473673 n.16G>A non_coding_transcript_exon_variant 0.28
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.32
rrl 1473699 n.42A>G non_coding_transcript_exon_variant 0.32
rrl 1473719 n.62G>A non_coding_transcript_exon_variant 0.3
rrl 1473721 n.64G>A non_coding_transcript_exon_variant 0.29
rrl 1473722 n.65G>T non_coding_transcript_exon_variant 0.31
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.28
rrl 1473744 n.87T>C non_coding_transcript_exon_variant 0.27
rrl 1473746 n.89T>A non_coding_transcript_exon_variant 0.27
rrl 1473747 n.90C>T non_coding_transcript_exon_variant 0.27
rrl 1473750 n.93C>A non_coding_transcript_exon_variant 0.27
rrl 1473753 n.96A>G non_coding_transcript_exon_variant 0.27
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.26
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.26
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.26
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.26
rrl 1473788 n.131A>C non_coding_transcript_exon_variant 0.28
rrl 1473789 n.133dupC non_coding_transcript_exon_variant 0.28
rrl 1473793 n.136G>A non_coding_transcript_exon_variant 0.28
rrl 1473794 n.137A>T non_coding_transcript_exon_variant 0.27
rrl 1473798 n.141_142insG non_coding_transcript_exon_variant 0.28
rrl 1473802 n.145C>G non_coding_transcript_exon_variant 0.28
rrl 1473805 n.149_150delCT non_coding_transcript_exon_variant 0.29
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.33
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.36
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.22
rrl 1473884 n.227C>T non_coding_transcript_exon_variant 0.19
rrl 1473887 n.230T>G non_coding_transcript_exon_variant 0.19
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.2
rrl 1473889 n.232G>A non_coding_transcript_exon_variant 0.2
rrl 1473898 n.241C>G non_coding_transcript_exon_variant 0.19
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.19
rrl 1474476 n.819C>G non_coding_transcript_exon_variant 0.3
rrl 1474483 n.826C>G non_coding_transcript_exon_variant 0.32
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.31
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.32
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.32
rrl 1474498 n.841G>A non_coding_transcript_exon_variant 0.31
rrl 1474505 n.848C>T non_coding_transcript_exon_variant 0.33
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.37
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.37
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.37
rrl 1474520 n.863A>C non_coding_transcript_exon_variant 0.45
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.45
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.45
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.45
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.44
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.46
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.51
rrl 1474558 n.901G>T non_coding_transcript_exon_variant 0.56
rrl 1474584 n.927C>T non_coding_transcript_exon_variant 0.61
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.69
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.69
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.68
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.7
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.72
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.7
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.7
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.7
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.75
rrl 1474694 n.1037C>T non_coding_transcript_exon_variant 0.75
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.74
rrl 1474717 n.1060_1061insGGTTC non_coding_transcript_exon_variant 0.73
rrl 1474734 n.1077G>A non_coding_transcript_exon_variant 0.73
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.73
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.72
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.73
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.73
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.74
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.73
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.73
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.74
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.74
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.74
rrl 1474806 n.1149A>G non_coding_transcript_exon_variant 0.74
rrl 1474822 n.1165G>T non_coding_transcript_exon_variant 0.72
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.71
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.71
rrl 1474905 n.1248T>A non_coding_transcript_exon_variant 0.63
rrl 1474927 n.1271delC non_coding_transcript_exon_variant 0.17
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.16
rrl 1475499 n.1842C>T non_coding_transcript_exon_variant 0.15
rrl 1475500 n.1843_1844insT non_coding_transcript_exon_variant 0.15
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.28
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.26
rrl 1475536 n.1879C>T non_coding_transcript_exon_variant 0.25
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.25
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.25
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.25
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.25
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.25
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.25
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.38
rrl 1475601 n.1945_1949delGGAAT non_coding_transcript_exon_variant 0.39
rrl 1475609 n.1952_1953insCTG non_coding_transcript_exon_variant 0.41
rrl 1475615 n.1959dupA non_coding_transcript_exon_variant 0.41
rrl 1475620 n.1963T>G non_coding_transcript_exon_variant 0.39
rrl 1475621 n.1964T>A non_coding_transcript_exon_variant 0.32
rrl 1475625 n.1969dupT non_coding_transcript_exon_variant 0.41
rrl 1475633 n.1976G>T non_coding_transcript_exon_variant 0.39
rrl 1475636 n.1979A>T non_coding_transcript_exon_variant 0.38
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.38
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.38
rrl 1475639 n.1982C>T non_coding_transcript_exon_variant 0.38
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.41
rrl 1475650 n.1993A>G non_coding_transcript_exon_variant 0.41
rrl 1475655 n.1998T>A non_coding_transcript_exon_variant 0.42
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.43
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.47
rrl 1475696 n.2039T>A non_coding_transcript_exon_variant 0.57
rrl 1475697 n.2040C>T non_coding_transcript_exon_variant 0.58
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.58
rrl 1475703 n.2046A>T non_coding_transcript_exon_variant 0.61
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.78
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.8
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.8
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.81
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.81
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.81
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.81
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.76
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.74
rrl 1475963 n.2306G>A non_coding_transcript_exon_variant 0.7
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.6
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.57
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.58
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.57
rrl 1475989 n.2332T>G non_coding_transcript_exon_variant 0.57
rrl 1475990 n.2333G>C non_coding_transcript_exon_variant 0.57
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.59
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.57
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.25
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.4
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.41
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.64
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.66
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.72
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.72
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.72
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.71
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.72
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.68
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.67
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.67
rrl 1476255 n.2598A>G non_coding_transcript_exon_variant 0.67
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.66
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.65
rrl 1476267 n.2610G>A non_coding_transcript_exon_variant 0.65
rrl 1476268 n.2611A>G non_coding_transcript_exon_variant 0.65
rrl 1476275 n.2618T>C non_coding_transcript_exon_variant 0.65
rrl 1476276 n.2619C>T non_coding_transcript_exon_variant 0.65
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.64
rrl 1476288 n.2631T>C non_coding_transcript_exon_variant 0.65
rrl 1476292 n.2637_2640delACCC non_coding_transcript_exon_variant 0.64
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.62
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.62
rrl 1476311 n.2654G>T non_coding_transcript_exon_variant 0.61
rrl 1476312 n.2655T>G non_coding_transcript_exon_variant 0.63
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.68
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.7
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.7
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.65
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.65
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.68
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.67
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.67
rrl 1476519 n.2862C>T non_coding_transcript_exon_variant 0.67
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.66
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.66
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.66
rrl 1476534 n.2877A>T non_coding_transcript_exon_variant 0.65
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.64
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.64
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.64
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.66
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.54
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.54
rrl 1476594 n.2937C>A non_coding_transcript_exon_variant 0.52
rrl 1476603 n.2946G>T non_coding_transcript_exon_variant 0.47
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.45
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.45
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.43
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.43
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.43
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 0.43
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.43
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.29
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.25
rrl 1476670 n.3013A>G non_coding_transcript_exon_variant 0.18
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.11
rpsA 1834210 c.669C>T synonymous_variant 0.12
rpsA 1834213 c.672G>C synonymous_variant 0.12
rpsA 1834222 c.681T>C synonymous_variant 0.12
rpsA 1834228 c.687C>T synonymous_variant 0.13
rpsA 1834234 c.693G>C synonymous_variant 0.13
rpsA 1834240 c.699T>A synonymous_variant 0.14
rpsA 1834243 c.702G>C synonymous_variant 0.14
rpsA 1834249 c.708T>C synonymous_variant 0.16
rpsA 1834255 c.714C>G synonymous_variant 0.16
rpsA 1834261 c.720A>G synonymous_variant 0.15
rpsA 1834264 c.723G>C synonymous_variant 0.15
rpsA 1834279 c.738C>T synonymous_variant 0.17
rpsA 1834286 p.Ser249Gly missense_variant 0.16
rpsA 1834294 c.753G>C synonymous_variant 0.16
rpsA 1834298 p.Gln253Thr missense_variant 0.15
rpsA 1834303 c.762T>C synonymous_variant 0.15
rpsA 1834327 c.786G>C synonymous_variant 0.22
rpsA 1834348 c.807T>G synonymous_variant 0.24
rpsA 1834354 c.813G>C synonymous_variant 0.22
rpsA 1834357 c.816T>C synonymous_variant 0.22
rpsA 1834361 c.820_822delTTGinsCTC synonymous_variant 0.23
rpsA 1834366 c.825A>G synonymous_variant 0.23
rpsA 1834378 c.837T>G synonymous_variant 0.22
rpsA 1834387 c.846C>T synonymous_variant 0.21
rpsA 1834395 p.Arg285Gln missense_variant 0.21
rpsA 1834408 c.867C>G synonymous_variant 0.19
rpsA 1834411 c.870T>C synonymous_variant 0.18
rpsA 1834416 p.Ala292Val missense_variant 0.18
rpsA 1834423 c.882G>C synonymous_variant 0.18
rpsA 1834859 p.Ala440Thr missense_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2103173 c.-132delG upstream_gene_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155503 c.609C>T synonymous_variant 1.0
katG 2156025 c.87C>A synonymous_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2168011 p.Ser868Arg missense_variant 1.0
PPE35 2168319 p.Thr765Ile missense_variant 1.0
PPE35 2168814 c.1798dupA frameshift_variant 1.0
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0
Rv1979c 2223062 p.Thr35Ala missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv1979c 2223320 c.-156T>C upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
folC 2746245 p.Ala452Thr missense_variant 1.0
ribD 2987615 c.777A>G stop_lost&splice_region_variant 1.0
ald 3086728 c.-92C>T upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087084 c.266delA frameshift_variant 1.0
Rv3083 3448783 p.Val94Ile missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3474427 p.Val141Ile missense_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 1.0
Rv3236c 3611987 p.Leu377Pro missense_variant 1.0
rpoA 3878630 c.-124delC upstream_gene_variant 1.0
clpC1 4038403 c.2302T>C synonymous_variant 1.0
clpC1 4039691 c.1014G>C synonymous_variant 0.16
clpC1 4039697 c.1008C>T synonymous_variant 0.17
clpC1 4039714 p.Tyr331His missense_variant 0.2
clpC1 4039724 c.981A>G synonymous_variant 0.18
clpC1 4039733 c.972G>C synonymous_variant 0.16
clpC1 4039736 c.969C>G synonymous_variant 0.16
clpC1 4039739 c.966C>G synonymous_variant 0.17
clpC1 4039742 c.963C>T synonymous_variant 0.17
clpC1 4039751 c.954A>G synonymous_variant 0.15
clpC1 4039754 c.951G>C synonymous_variant 0.15
clpC1 4039757 c.948A>G synonymous_variant 0.15
clpC1 4039766 c.939T>C synonymous_variant 0.15
clpC1 4039773 p.Lys311Met missense_variant 0.14
clpC1 4039778 c.927A>G synonymous_variant 0.14
clpC1 4039781 c.924G>C synonymous_variant 0.14
clpC1 4039871 c.834C>G synonymous_variant 0.17
clpC1 4039875 p.Asn277Arg missense_variant 0.18
clpC1 4039898 c.807C>G synonymous_variant 0.17
clpC1 4039901 c.804C>T synonymous_variant 0.19
clpC1 4039925 c.780C>G synonymous_variant 0.14
clpC1 4039976 p.Lys243Thr missense_variant 0.15
clpC1 4039982 p.Thr241Ile missense_variant 0.16
clpC1 4039991 c.714G>T synonymous_variant 0.15
clpC1 4040002 p.His235Asn missense_variant 0.15
clpC1 4040003 c.702G>C synonymous_variant 0.15
clpC1 4040009 c.696C>G synonymous_variant 0.15
clpC1 4040021 c.684A>T synonymous_variant 0.18
clpC1 4040024 c.681A>G synonymous_variant 0.18
clpC1 4040030 c.675C>G synonymous_variant 0.17
clpC1 4040033 c.672G>A synonymous_variant 1.0
clpC1 4040063 c.642G>C synonymous_variant 0.13
embC 4240671 p.Thr270Ile missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4242970 c.-263C>T upstream_gene_variant 1.0
embA 4244220 c.988C>T synonymous_variant 1.0
embB 4246551 p.Asn13Ser missense_variant 0.93
embB 4246864 c.351C>T synonymous_variant 1.0
embB 4247646 p.Glu378Ala missense_variant 1.0
embB 4247791 c.1278C>T synonymous_variant 1.0
aftB 4267858 p.Ile327Val missense_variant 1.0
aftB 4269351 c.-515C>T upstream_gene_variant 1.0
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
fbiC 1305494 c.2565_*56delCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN frameshift_variant&stop_lost&splice_region_variant 1.0