TB-Profiler result

Run: SRR10993951
Summary

Run ID: SRR10993951

Sample name:

Date: 2024-04-16T10:29:24.676464

Number of reads: 735854

Percentage reads mapped: 47.79

Median coverage: 34.0

Strain: La1.6

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.6 M.bovis None 1.0
La1 M.bovis None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser441Ala Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Leu464Met Mutation from literature
isoniazid
ethambutol
pyrazinamide pncA p.His57Asp Assoc w R
streptomycin rrs n.799C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.2565_*56delCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761127 p.Ser441Ala missense_variant 0.33 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761196 p.Leu464Met missense_variant 0.35 rifampicin Mutation from literature
fbiC 1305494 c.2565_*56delCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN frameshift_variant&stop_lost&splice_region_variant 1.0 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
amikacin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.58 capreomycin Assoc w R
amikacin Assoc w R
kanamycin Assoc w R
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 467 p.His156Arg missense_variant 1.0 isoniazid Not assoc w R
gyrB 5752 c.513G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6406 c.1167C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6446 p.Ala403Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 7042 c.1803C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8285 c.984C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9217 p.Asp639Ala missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13197 p.Thr121Ser missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13228 c.330delG frameshift_variant 1.0 isoniazid Uncertain significance
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
rpoB 761051 c.1245G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>T synonymous_variant 0.26 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761088 c.1282_1284delAGCinsTCG synonymous_variant 0.29 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.26 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.26 rifampicin
rpoB 761111 c.1305C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761126 c.1320G>C synonymous_variant 0.33 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761156 c.1350G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761177 c.1371G>C synonymous_variant 0.33 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>C synonymous_variant 0.36 rifampicin
rpoB 761186 p.Glu460Asp missense_variant 0.36 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761194 p.Gly463Ala missense_variant 0.35 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.34 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.34 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762057 p.Ile751Val missense_variant 0.17 rifampicin Uncertain significance
rpoB 762062 c.2256T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762080 c.2274G>C synonymous_variant 0.19 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762119 c.2313C>G synonymous_variant 0.19 rifampicin
rpoB 762120 p.Asp772Pro missense_variant 0.19 rifampicin
rpoB 762125 p.Glu773Asp missense_variant 0.19 rifampicin
rpoB 762127 p.Val774Ala missense_variant 0.19 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.19 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.19 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.19 rifampicin
rpoB 762146 p.Glu780Asp missense_variant 0.19 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762156 c.2350_2352delGTGinsAC frameshift_variant&missense_variant 0.21 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762177 p.Arg791Thr missense_variant 0.2 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>T synonymous_variant 0.12 rifampicin
rpoB 762251 c.2445G>C synonymous_variant 0.12 rifampicin
rpoB 762878 p.Ile1024Met missense_variant 0.18 rifampicin
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.18 rifampicin
rpoB 762887 c.3081G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 762896 c.-474G>C upstream_gene_variant 0.21 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 762911 c.-459C>T upstream_gene_variant 0.27 rifampicin
rpoB 762917 c.3111C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 762980 c.-390T>C upstream_gene_variant 0.36 rifampicin
rpoC 762983 c.-387C>T upstream_gene_variant 0.36 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.36 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763002 c.3197dupA frameshift_variant 0.39 rifampicin
rpoB 763006 c.3201delC frameshift_variant 0.4 rifampicin
rpoB 763014 c.3208_3210delATGinsCC frameshift_variant&missense_variant 0.44 rifampicin
rpoB 763017 p.Gln1071Glu missense_variant 0.41 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 0.61 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763053 c.3247T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.37 rifampicin
rpoB 763085 c.3279C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763100 c.-270G>A upstream_gene_variant 0.35 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 0.35 rifampicin
rpoB 763122 c.3316_3318delATCinsCG frameshift_variant&missense_variant 0.26 rifampicin
rpoB 763127 c.3321G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763130 p.Glu1108Asp missense_variant 0.26 rifampicin
rpoC 763136 c.-234C>A upstream_gene_variant 0.28 rifampicin
rpoC 763504 c.135C>A synonymous_variant 0.13 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.13 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.19 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.19 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.19 rifampicin
rpoC 763537 c.168C>T synonymous_variant 0.19 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763550 p.Tyr61Ala missense_variant 0.19 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763585 c.216C>G synonymous_variant 0.17 rifampicin
rpoC 763621 c.252C>T synonymous_variant 0.2 rifampicin
rpoC 763630 c.261G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>T synonymous_variant 0.19 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764491 c.1122G>C synonymous_variant 0.36 rifampicin
rpoC 764498 p.Ser377Ala missense_variant 0.36 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.33 rifampicin
rpoC 764507 p.Ala380Ser missense_variant 0.33 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.3 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>T synonymous_variant 0.3 rifampicin
rpoC 764536 c.1167G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>G synonymous_variant 0.32 rifampicin
rpoC 764548 c.1179G>A synonymous_variant 0.35 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.26 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.26 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.26 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764679 p.Lys437Ser missense_variant 0.35 rifampicin
rpoC 764683 c.1314G>C synonymous_variant 0.35 rifampicin
rpoC 764690 p.Cys441Ala missense_variant 0.36 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764705 p.Leu446Thr missense_variant 0.4 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764737 c.1368G>C synonymous_variant 0.36 rifampicin
rpoC 764746 c.1377G>C synonymous_variant 0.37 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764755 c.1386C>T synonymous_variant 0.41 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.4 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.37 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764808 p.Arg480His missense_variant 0.38 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.36 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764843 p.Ala492Thr missense_variant 0.3 rifampicin
rpoC 764848 c.1479G>A synonymous_variant 0.29 rifampicin
rpoC 764858 c.1489_1491delTTGinsCC frameshift_variant&missense_variant 0.28 rifampicin
rpoC 764863 c.1494G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>G synonymous_variant 0.24 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1129c 1254582 c.-48A>G upstream_gene_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472092 n.247C>T non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472120 n.275G>A non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472223 n.378C>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472228 n.383G>C non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472245 n.400C>A non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472251 n.406G>C non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472279 n.434T>G non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472293 n.448C>A non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472298 n.453_466delGTCCGGGTTCTCTCinsCCTCTT non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472314 n.469_470delATinsG non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 0.73 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472380 n.535G>A non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472427 n.582T>G non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472431 n.586G>A non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472434 n.589_590insC non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472437 n.592T>C non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472438 n.594delC non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472443 n.598A>G non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472448 n.603T>G non_coding_transcript_exon_variant 0.59 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472451 n.606C>A non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472452 n.607G>C non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472460 n.615T>G non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472461 n.616G>T non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>C non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472474 n.629C>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472476 n.631A>G non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472484 n.639A>T non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>A non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472506 n.661A>T non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472572 n.727T>A non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472591 n.746G>A non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472841 n.996G>A non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472845 n.1000G>C non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472846 n.1001C>G non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>C non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472851 n.1006A>G non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472854 n.1009G>A non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472856 n.1011T>C non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>C non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472867 n.1022_1025delTTGTinsCTTTGG non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472874 n.1029C>T non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473047 n.1202C>T non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473091 n.1246G>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>A non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473094 n.1249T>A non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>C non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473109 n.1264T>G non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473111 n.1266A>C non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473147 n.1302G>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473157 n.1312C>T non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473164 n.1319C>A non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443delCinsAGTTT non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.54 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473298 n.1453A>G non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473305 n.1460G>T non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474476 n.819C>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474483 n.826C>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474498 n.841G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474505 n.848C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474520 n.863A>C non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474558 n.901G>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474584 n.927C>T non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474694 n.1037C>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGGTTC non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474734 n.1077G>A non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474753 n.1096_1097delACinsT non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.74 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.74 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474806 n.1149A>G non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1474822 n.1165G>T non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>A non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475536 n.1879C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid Uncertain significance
rrl 1475601 n.1945_1949delGGAAT non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475609 n.1952_1953insCTG non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475615 n.1959dupA non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475620 n.1963T>G non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475621 n.1964T>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475625 n.1969dupT non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475633 n.1976G>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475636 n.1979A>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475637 n.1980T>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475650 n.1993A>G non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475655 n.1998T>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475696 n.2039T>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1475697 n.2040C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475703 n.2046A>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475963 n.2306G>A non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.57 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>G non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475990 n.2333G>C non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.72 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.72 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.72 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476255 n.2598A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.65 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476267 n.2610G>A non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1476268 n.2611A>G non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1476275 n.2618T>C non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1476276 n.2619C>T non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476288 n.2631T>C non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1476292 n.2637_2640delACCC non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476299 n.2642_2643delCGinsATGGCT non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>T non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1476312 n.2655T>G non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.65 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.68 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.67 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476519 n.2862C>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476534 n.2877A>T non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.54 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1476603 n.2946G>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.43 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1834327 c.786G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834348 c.807T>G synonymous_variant 0.24 pyrazinamide
rpsA 1834354 c.813G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834361 c.820_822delTTGinsCC frameshift_variant&missense_variant 0.23 pyrazinamide Uncertain significance
rpsA 1834366 c.825A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>G synonymous_variant 0.22 pyrazinamide
rpsA 1834387 c.846C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834395 p.Arg285Gln missense_variant 0.21 pyrazinamide
rpsA 1834408 c.867C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834416 p.Ala292Val missense_variant 0.18 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834859 p.Ala440Thr missense_variant 1.0 pyrazinamide Uncertain significance
tsnR 1854289 c.684C>T synonymous_variant 1.0 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
ndh 2103173 c.-132delG upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
katG 2156025 c.87C>A synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168011 p.Ser868Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168319 p.Thr765Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168814 c.1798dupA frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223062 p.Thr35Ala missense_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223320 c.-156T>C upstream_gene_variant 1.0 clofazimine
bedaquiline
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
folC 2746245 p.Ala452Thr missense_variant 1.0 para-aminosalicylic_acid
Rv2477c 2782927 c.1116A>G synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
ribD 2987615 c.777A>G stop_lost&splice_region_variant 1.0 para-aminosalicylic_acid
Rv2681 2997325 p.Ala196Val missense_variant 1.0 capreomycin Uncertain significance
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3083 3448783 p.Val94Ile missense_variant 1.0 ethionamide Uncertain significance
Rv3236c 3611987 p.Leu377Pro missense_variant 1.0 pyrazinamide
lpqB 3623730 p.Ser394Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624350 c.561G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624593 c.318G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624710 c.201G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
clpC1 4038403 c.2302T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4039714 p.Tyr331His missense_variant 0.2 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039736 c.969C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039754 c.951G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039773 p.Lys311Met missense_variant 0.14 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039871 c.834C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039875 p.Asn277Arg missense_variant 0.18 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039901 c.804C>T synonymous_variant 0.19 pyrazinamide
clpC1 4040033 c.672G>A synonymous_variant 1.0 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242970 c.3108C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4246551 p.Asn13Ser missense_variant 0.93 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247791 c.1278C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
aftB 4267858 p.Ile327Val missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R