TB-Profiler result

Run: 43293b64-8c7d-4015-8cf4-30116ffbb723
Summary

Run ID: 43293b64-8c7d-4015-8cf4-30116ffbb723

Sample name:

Date: 25-04-2024 08:09:43

Number of reads: 310691

Percentage reads mapped: 17.09

Median coverage: 6

Strain: lineage4.7

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.7 Euro-American (mainly T) None 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG c.349dupG Uncertain significance
c.344delT Uncertain significance
ethambutol
pyrazinamide
moxifloxacin
levofloxacin
bedaquiline
delamanid
pretomanid
linezolid
streptomycin
amikacin
kanamycin
capreomycin
clofazimine
ethionamide
para-aminosalicylic_acid
cycloserine
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2155762 c.349dupG frameshift_variant 0.61 isoniazid Uncertain significance
katG 2155767 c.344delT frameshift_variant 0.65 isoniazid Uncertain significance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
rpoB 760157 c.351A>G synonymous_variant 0.6 rifampicin
rpoB 760181 c.375T>G synonymous_variant 0.64 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.6 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.57 rifampicin
rpoB 760233 c.427_429delAGTinsTCG synonymous_variant 0.5 rifampicin
rpoB 760241 c.435G>C synonymous_variant 0.5 rifampicin
rpoB 760244 c.438G>C synonymous_variant 0.47 rifampicin
rpoB 760253 c.447T>C synonymous_variant 0.47 rifampicin
rpoB 760256 c.450C>T synonymous_variant 0.47 rifampicin
rpoB 760262 c.456G>C synonymous_variant 0.47 rifampicin
rpoB 760271 c.465C>G synonymous_variant 0.47 rifampicin
rpoB 760274 p.Glu156Asp missense_variant 0.47 rifampicin Uncertain significance
rpoB 760298 c.492G>C synonymous_variant 0.46 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 1.0 rifampicin
rpoB 760380 p.Thr192Pro missense_variant 0.94 rifampicin
rpoB 760394 c.588C>G synonymous_variant 0.95 rifampicin
rpoB 760400 c.594G>C synonymous_variant 0.95 rifampicin
rpoB 760407 p.Ser201Ala missense_variant 0.95 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.92 rifampicin
rpoB 760460 c.654G>C synonymous_variant 0.86 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.86 rifampicin
rpoB 760478 c.672C>T synonymous_variant 0.85 rifampicin
rpoB 760481 c.675G>C synonymous_variant 0.85 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.85 rifampicin
rpoB 760487 c.681G>C synonymous_variant 0.85 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.77 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.71 rifampicin
rpoB 760533 p.Val243Leu missense_variant 0.72 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.75 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.75 rifampicin
rpoB 760553 c.747C>G synonymous_variant 0.7 rifampicin
rpoB 760565 c.759A>G synonymous_variant 0.71 rifampicin
rpoB 760568 c.762G>C synonymous_variant 0.76 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.77 rifampicin
rpoB 760589 c.783C>G synonymous_variant 0.78 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.78 rifampicin Uncertain significance
rpoB 760611 c.805_807delTTGinsCTC synonymous_variant 0.76 rifampicin
rpoB 760634 c.828T>C synonymous_variant 0.78 rifampicin
rpoB 760646 c.840C>G synonymous_variant 0.65 rifampicin
rpoB 760649 c.843G>C synonymous_variant 0.62 rifampicin
rpoB 760652 c.846C>G synonymous_variant 0.73 rifampicin
rpoB 760655 c.849A>G synonymous_variant 0.67 rifampicin
rpoB 760661 c.855A>G synonymous_variant 0.67 rifampicin
rpoB 760670 c.864G>C synonymous_variant 0.71 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.67 rifampicin
rpoB 760679 c.873A>G synonymous_variant 0.67 rifampicin
rpoB 760683 c.877T>C synonymous_variant 0.67 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.55 rifampicin
rpoB 760953 p.Ile383Leu missense_variant 0.55 rifampicin
rpoB 760958 c.1152G>C synonymous_variant 0.55 rifampicin
rpoB 760961 c.1155C>G synonymous_variant 0.55 rifampicin
rpoB 760965 p.Met387Leu missense_variant 0.6 rifampicin
rpoB 760970 c.1164G>C synonymous_variant 0.6 rifampicin
rpoB 760973 c.1167G>C synonymous_variant 0.55 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.55 rifampicin
rpoB 760985 c.1179G>C synonymous_variant 0.55 rifampicin
rpoB 760988 c.1182C>G synonymous_variant 0.55 rifampicin
rpoB 760991 c.1185G>T synonymous_variant 0.55 rifampicin
rpoB 760997 c.1191G>C synonymous_variant 0.6 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.6 rifampicin
rpoB 761036 c.1230G>C synonymous_variant 0.6 rifampicin
rpoB 761111 c.1305C>T synonymous_variant 0.55 rifampicin
rpoB 761126 c.1320G>C synonymous_variant 0.68 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.68 rifampicin
rpoB 761133 c.1327T>C synonymous_variant 0.68 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.74 rifampicin
rpoB 761162 c.1356G>C synonymous_variant 0.75 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.75 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.78 rifampicin
rpoB 761180 c.1374A>G synonymous_variant 0.82 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.86 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.86 rifampicin
rpoB 761198 c.1392G>C synonymous_variant 0.87 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.87 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.96 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.93 rifampicin
rpoB 761261 c.1455G>C synonymous_variant 0.88 rifampicin
rpoB 761264 c.1458C>G synonymous_variant 0.88 rifampicin
rpoB 761273 c.1467T>C synonymous_variant 0.85 rifampicin
rpoB 761288 c.1482G>C synonymous_variant 0.83 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.64 rifampicin
rpoB 761519 p.Asp571Glu missense_variant 0.29 rifampicin
rpoB 761529 p.Val575Ile missense_variant 0.42 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.6 rifampicin
rpoB 761549 c.1743G>C synonymous_variant 0.6 rifampicin
rpoB 761555 c.1749G>C synonymous_variant 0.62 rifampicin
rpoB 761558 c.1752C>G synonymous_variant 0.6 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.68 rifampicin
rpoB 761573 c.1767C>G synonymous_variant 0.7 rifampicin
rpoB 761579 c.1773G>C synonymous_variant 0.7 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.68 rifampicin
rpoB 761615 c.1809A>G synonymous_variant 0.64 rifampicin
rpoB 761627 c.1821C>T synonymous_variant 0.62 rifampicin
rpoB 761633 c.1827G>C synonymous_variant 0.57 rifampicin
rpoB 761649 c.1843_1844delAGinsTC synonymous_variant 0.52 rifampicin
rpoB 761655 p.Ala617Ser missense_variant 0.48 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.58 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.59 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.64 rifampicin
rpoB 762065 c.2259T>G synonymous_variant 0.64 rifampicin
rpoB 762074 c.2268C>G synonymous_variant 0.67 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.64 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.77 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.8 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.81 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.81 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.82 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.79 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.79 rifampicin
rpoB 762156 p.Val784Ile missense_variant 0.83 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.84 rifampicin
rpoB 762176 c.2370T>C synonymous_variant 0.88 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.9 rifampicin
rpoB 762218 c.2412T>C synonymous_variant 0.9 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.9 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.88 rifampicin
rpoB 762251 c.2445G>C synonymous_variant 0.86 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.82 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.82 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.8 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.75 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.76 rifampicin
rpoB 762299 c.2493G>C synonymous_variant 0.79 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.41 rifampicin
rpoB 762905 p.Asp1033Glu missense_variant 0.53 rifampicin
rpoC 762929 c.-441G>C upstream_gene_variant 0.57 rifampicin
rpoC 762947 c.-423C>G upstream_gene_variant 0.6 rifampicin
rpoC 762962 c.-408C>T upstream_gene_variant 0.67 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.69 rifampicin
rpoC 762995 c.-375G>C upstream_gene_variant 0.69 rifampicin
rpoC 763013 c.-357C>G upstream_gene_variant 0.72 rifampicin
rpoC 763022 c.-348C>G upstream_gene_variant 0.71 rifampicin
rpoC 763028 c.-342T>C upstream_gene_variant 0.72 rifampicin
rpoC 763031 c.-339T>C upstream_gene_variant 0.75 rifampicin
rpoC 763052 c.-318G>C upstream_gene_variant 0.75 rifampicin
rpoC 763053 c.-317_-315delTTGinsCTC upstream_gene_variant 0.75 rifampicin
rpoC 763067 c.-303C>G upstream_gene_variant 0.77 rifampicin
rpoC 763070 c.-300T>C upstream_gene_variant 0.77 rifampicin
rpoB 763074 p.Thr1090Val missense_variant 0.76 rifampicin
rpoC 763088 c.-282C>G upstream_gene_variant 0.79 rifampicin
rpoC 763115 c.-255T>C upstream_gene_variant 0.8 rifampicin
rpoC 763127 c.-243G>C upstream_gene_variant 0.87 rifampicin
rpoC 763133 c.-237G>C upstream_gene_variant 0.81 rifampicin
rpoC 763160 c.-210G>C upstream_gene_variant 0.71 rifampicin
rpoC 763166 c.-204A>G upstream_gene_variant 0.69 rifampicin
rpoC 763169 c.-201A>G upstream_gene_variant 0.7 rifampicin
rpoC 763172 c.-198G>C upstream_gene_variant 0.7 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.73 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.77 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.79 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.71 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.83 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.91 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.91 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.96 rifampicin
rpoC 763618 c.249C>T synonymous_variant 0.96 rifampicin
rpoC 763660 c.291T>C synonymous_variant 0.83 rifampicin
rpoC 763696 c.327T>C synonymous_variant 0.86 rifampicin
rpoC 763699 c.330G>C synonymous_variant 0.86 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.86 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.92 rifampicin
rpoC 763709 c.340C>T synonymous_variant 0.92 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.92 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.92 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.91 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.91 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.83 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.82 rifampicin
rpoC 764153 p.Gln262Lys missense_variant 0.5 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.67 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.71 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.77 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.77 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.77 rifampicin
rpoC 764215 c.846A>C synonymous_variant 0.83 rifampicin
rpoC 764216 p.Asn283Ser missense_variant 0.83 rifampicin
rpoC 764239 c.870T>C synonymous_variant 0.84 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.76 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.76 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.76 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.78 rifampicin
rpoC 764297 p.Met310Leu missense_variant 0.85 rifampicin
rpoC 764308 c.939G>C synonymous_variant 0.76 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.65 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.7 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.71 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.74 rifampicin
rpoC 764398 c.1029G>C synonymous_variant 0.71 rifampicin
rpoC 764404 c.1035C>T synonymous_variant 0.71 rifampicin
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.71 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.71 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.69 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.69 rifampicin
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.69 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.69 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.65 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.65 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.68 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.68 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.74 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.71 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.74 rifampicin
rpoC 764536 c.1167G>T synonymous_variant 0.7 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.77 rifampicin
rpoC 764548 c.1179G>A synonymous_variant 0.75 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.84 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.82 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.91 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.84 rifampicin
rpoC 764635 c.1266C>G synonymous_variant 0.84 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.81 rifampicin
rpoC 764662 c.1293G>C synonymous_variant 0.83 rifampicin
rpoC 764665 c.1296C>G synonymous_variant 0.83 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.85 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.87 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.89 rifampicin
rpoC 764746 c.1377G>C synonymous_variant 0.91 rifampicin
rpoC 764755 c.1386C>T synonymous_variant 0.91 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.91 rifampicin
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.91 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.91 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.9 rifampicin
rpoC 764803 c.1434C>G synonymous_variant 0.9 rifampicin
rpoC 764809 c.1440C>G synonymous_variant 0.9 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.88 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.88 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.88 rifampicin
rpoC 764827 c.1458G>C synonymous_variant 0.88 rifampicin
rpoC 764854 c.1485G>C synonymous_variant 0.77 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.76 rifampicin
rpoC 764863 c.1494G>C synonymous_variant 0.74 rifampicin
rpoC 764869 c.1500C>T synonymous_variant 0.69 rifampicin
rpoC 764872 c.1503A>C synonymous_variant 0.67 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.61 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.58 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.58 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.55 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.35 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.35 rifampicin
rpoC 764917 c.1548G>C synonymous_variant 0.35 rifampicin
rpoC 764920 c.1551G>C synonymous_variant 0.35 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.4 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.58 rifampicin
rpoC 764948 c.1579_1581delTTGinsCTC synonymous_variant 0.61 rifampicin
rpoC 764953 c.1584G>C synonymous_variant 0.61 rifampicin
rpoC 764962 c.1593G>C synonymous_variant 0.68 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.67 rifampicin
rpoC 765004 c.1635G>C synonymous_variant 0.82 rifampicin
rpoC 765007 c.1638T>G synonymous_variant 0.81 rifampicin
rpoC 765008 c.1639T>C synonymous_variant 0.81 rifampicin
rpoC 765011 c.1642_1643delAGinsTC synonymous_variant 0.81 rifampicin
rpoC 765016 c.1647C>G synonymous_variant 0.81 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.81 rifampicin
rpoC 765034 c.1665T>C synonymous_variant 0.7 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.7 rifampicin
rpoC 765041 c.1672T>C synonymous_variant 0.7 rifampicin
rpoC 765047 c.1678T>C synonymous_variant 0.7 rifampicin
rpoC 765055 c.1686C>G synonymous_variant 0.7 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.65 rifampicin
rpoC 765082 c.1713G>C synonymous_variant 0.65 rifampicin
rpoC 765085 c.1716T>C synonymous_variant 0.65 rifampicin
rpoC 765089 c.1720_1722delTTGinsCTC synonymous_variant 0.65 rifampicin
rpoC 765100 c.1731G>C synonymous_variant 0.61 rifampicin
rpoC 765103 c.1734G>T synonymous_variant 0.61 rifampicin
rpoC 765116 p.Thr583Ala missense_variant 0.12 rifampicin
rpoC 765121 c.1752G>C synonymous_variant 0.62 rifampicin
rpoC 765128 p.Tyr587His missense_variant 0.4 rifampicin
rpoC 765478 c.2109T>G synonymous_variant 0.5 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.59 rifampicin
rpoC 765544 c.2175C>G synonymous_variant 0.71 rifampicin
rpoC 765547 c.2178C>T synonymous_variant 0.71 rifampicin
rpoC 765548 c.2179_2181delAGCinsTCG synonymous_variant 0.71 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.62 rifampicin
rpoC 765569 p.Ala734Ser missense_variant 0.62 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.6 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.6 rifampicin
rpoC 765590 p.Arg741Ser missense_variant 0.57 rifampicin Uncertain significance
rpoC 765601 p.Glu744Asp missense_variant 0.54 rifampicin
rpoC 765612 p.His748Arg missense_variant 0.4 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.77 rifampicin
rpoC 765884 p.Ser839Thr missense_variant 0.15 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.83 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.87 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.82 rifampicin
rpoC 765940 c.2571A>T synonymous_variant 0.75 rifampicin
rpoC 765946 c.2577C>T synonymous_variant 0.75 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.75 rifampicin
rpoC 765952 c.2583G>C synonymous_variant 0.69 rifampicin
rpoC 765955 c.2586C>T synonymous_variant 0.64 rifampicin
rpoC 765961 c.2592G>T synonymous_variant 0.64 rifampicin
rpoC 765962 c.2593T>C synonymous_variant 0.64 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.64 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.69 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.33 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.27 rifampicin
rpoC 766357 c.2988C>T synonymous_variant 0.27 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.33 rifampicin
rpoC 766375 c.3006C>G synonymous_variant 0.33 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.3 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.36 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.4 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.4 rifampicin
rpoC 766942 c.3573C>T synonymous_variant 0.7 rifampicin
rpoC 766945 c.3576A>C synonymous_variant 0.73 rifampicin
rpoC 766948 c.3579G>C synonymous_variant 0.82 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.83 rifampicin
rpoC 766990 c.3621G>C synonymous_variant 0.75 rifampicin
rpoC 767008 c.3639G>C synonymous_variant 0.82 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.8 rifampicin
rpoC 767017 c.3648C>G synonymous_variant 0.8 rifampicin
rpoC 767023 c.3654C>T synonymous_variant 0.8 rifampicin
rpsL 781751 c.192G>C synonymous_variant 0.62 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.62 streptomycin
rpsL 781769 c.210G>A synonymous_variant 0.75 streptomycin
rpsL 781781 c.222G>T synonymous_variant 0.82 streptomycin
rpsL 781793 c.234G>T synonymous_variant 0.86 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.85 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.85 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.85 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.85 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.9 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.86 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.87 streptomycin
rpsL 781838 c.279G>T synonymous_variant 0.91 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.86 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.89 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.93 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.89 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.88 streptomycin
rpsL 781901 c.342C>G synonymous_variant 0.88 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.92 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.88 streptomycin
rrs 1471981 n.136C>T non_coding_transcript_exon_variant 0.3 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.5 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.5 linezolid
kanamycin Uncertain significance
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.85 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.83 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.81 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.91 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.91 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.94 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.86 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.86 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473081 n.1236C>G non_coding_transcript_exon_variant 0.82 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473082 n.1237G>C non_coding_transcript_exon_variant 0.82 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.79 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.73 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.73 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.64 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.64 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.6 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.6 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473129 n.1284C>G non_coding_transcript_exon_variant 0.6 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473130 n.1285G>C non_coding_transcript_exon_variant 0.6 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.67 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.61 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.71 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrl 1474621 n.964A>T non_coding_transcript_exon_variant 0.17 linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.73 linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.73 linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.73 linezolid
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.73 linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.73 linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.73 linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.73 linezolid
rrl 1474674 n.1017A>C non_coding_transcript_exon_variant 0.69 linezolid
rrl 1474675 n.1018C>A non_coding_transcript_exon_variant 0.67 linezolid
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.73 linezolid
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.67 linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.75 linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.86 linezolid
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.9 linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.91 linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.8 linezolid
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.75 linezolid
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.71 linezolid
rrl 1474822 n.1165G>C non_coding_transcript_exon_variant 0.71 linezolid
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.67 linezolid
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.69 linezolid
rrl 1474896 n.1239A>T non_coding_transcript_exon_variant 0.3 linezolid
rrl 1474901 n.1244A>G non_coding_transcript_exon_variant 0.27 linezolid
rrl 1474902 n.1245T>C non_coding_transcript_exon_variant 0.27 linezolid
rrl 1474905 n.1248T>G non_coding_transcript_exon_variant 0.27 linezolid
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.3 linezolid
rrl 1475109 n.1452C>T non_coding_transcript_exon_variant 0.3 linezolid
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.3 linezolid
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.3 linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.3 linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.73 linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.73 linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.73 linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.67 linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.65 linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.78 linezolid
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.79 linezolid
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.82 linezolid
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.73 linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.75 linezolid
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.75 linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.82 linezolid
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.82 linezolid
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.82 linezolid
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.82 linezolid
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.83 linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.86 linezolid
rrl 1476436 n.2779A>G non_coding_transcript_exon_variant 0.11 linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.89 linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.88 linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.88 linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.58 linezolid
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.64 linezolid
rpsA 1833709 c.168C>T synonymous_variant 0.44 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.3 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.42 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.45 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.45 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.5 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.6 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.6 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.6 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.64 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.6 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.75 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.82 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.83 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.96 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.93 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.93 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.93 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.93 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.93 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.9 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.93 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.93 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.93 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.92 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.89 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.89 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.91 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.95 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.83 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.79 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.58 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.54 pyrazinamide
rpsA 1834298 p.Gln253Thr missense_variant 0.44 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.41 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834327 c.786G>C synonymous_variant 0.54 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.5 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.71 pyrazinamide
rpsA 1834384 c.843A>G synonymous_variant 0.77 pyrazinamide
rpsA 1834387 c.846C>T synonymous_variant 0.77 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.83 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.83 pyrazinamide
rpsA 1834408 c.867C>G synonymous_variant 0.91 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.91 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCTC synonymous_variant 1.0 pyrazinamide
rpsA 1834456 c.915T>C synonymous_variant 1.0 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.92 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.92 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.85 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.83 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.82 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.85 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.9 pyrazinamide
rpsA 1834700 p.Gln387Asn missense_variant 0.91 pyrazinamide
rpsA 1834706 p.Asn389Glu missense_variant 0.75 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.69 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.73 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.71 pyrazinamide
rpsA 1834751 p.Leu404Ile missense_variant 0.56 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.67 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.67 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.57 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.57 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.57 pyrazinamide
rpsA 1834788 p.Ala416Gly missense_variant 0.57 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834804 c.1263C>G synonymous_variant 0.47 pyrazinamide
rpsA 1834810 c.1269C>T synonymous_variant 0.47 pyrazinamide
rpsA 1834813 c.1272G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834849 c.1308C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834854 p.Ala438Asp missense_variant 0.25 pyrazinamide
tlyA 1918555 p.Arg206Trp missense_variant 0.2 capreomycin
katG 2155662 c.450G>C synonymous_variant 0.45 isoniazid
katG 2155674 c.438G>C synonymous_variant 0.5 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.5 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.69 isoniazid
katG 2155696 p.Ala139Val missense_variant 0.69 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.58 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.55 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.55 isoniazid
katG 2155736 p.Met126Leu missense_variant 0.58 isoniazid
katG 2155740 p.Gly124Ala missense_variant 0.58 isoniazid Uncertain significance
katG 2155743 c.369G>C synonymous_variant 0.58 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.58 isoniazid
katG 2155755 c.357C>T synonymous_variant 0.58 isoniazid
katG 2155785 p.Ala109Ser missense_variant 0.69 isoniazid
katG 2155800 c.312G>C synonymous_variant 0.69 isoniazid
katG 2155806 c.306T>C synonymous_variant 0.69 isoniazid
eis 2714855 p.Gly160Ser missense_variant 0.2 kanamycin
amikacin
ahpC 2726636 c.444G>C synonymous_variant 0.73 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.73 isoniazid
ahpC 2726651 c.459G>C synonymous_variant 0.9 isoniazid
ahpC 2726717 c.525A>C synonymous_variant 0.8 isoniazid
ribD 2987417 p.Glu193Asp missense_variant 0.27 para-aminosalicylic_acid
ribD 2987587 p.Tyr250Phe missense_variant 0.25 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3073999 p.Arg158Lys missense_variant 0.3 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074007 c.465C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074010 p.Val154Ala missense_variant 0.27 para-aminosalicylic_acid
rpoA 3877587 p.Ser307Ala missense_variant 0.42 rifampicin
rpoA 3877593 c.915C>T synonymous_variant 0.42 rifampicin
rpoA 3877600 p.Gln303Ala missense_variant 0.46 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.68 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.68 rifampicin
rpoA 3877629 c.879C>G synonymous_variant 0.68 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.71 rifampicin
rpoA 3877659 c.849G>T synonymous_variant 0.71 rifampicin
rpoA 3877662 c.846C>T synonymous_variant 0.76 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.7 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.75 rifampicin
rpoA 3877683 c.825G>C synonymous_variant 0.73 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.74 rifampicin
rpoA 3877704 c.804G>T synonymous_variant 0.84 rifampicin
rpoA 3877728 c.780C>G synonymous_variant 0.81 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 0.81 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.82 rifampicin
rpoA 3877746 c.762G>C synonymous_variant 0.83 rifampicin
rpoA 3877752 p.Asp252Glu missense_variant 0.83 rifampicin
rpoA 3877764 p.Ala248Ser missense_variant 0.81 rifampicin
rpoA 3877770 p.Ser246Ala missense_variant 0.79 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.79 rifampicin
rpoA 3877782 c.726T>C synonymous_variant 0.82 rifampicin
rpoA 3877803 c.705G>C synonymous_variant 0.83 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.83 rifampicin
rpoA 3877836 c.672A>G synonymous_variant 0.83 rifampicin
rpoA 3877842 c.666A>C synonymous_variant 0.78 rifampicin
rpoA 3877845 c.663G>C synonymous_variant 0.78 rifampicin
rpoA 3877848 c.660C>G synonymous_variant 0.8 rifampicin
rpoA 3877856 c.652T>C synonymous_variant 0.81 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.8 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.81 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.8 rifampicin
rpoA 3877898 p.Pro204Ala missense_variant 0.8 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.8 rifampicin
rpoA 3877902 p.Ile202Met missense_variant 0.8 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.8 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.8 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.86 rifampicin
rpoA 3877935 p.Lys191Arg missense_variant 0.85 rifampicin
rpoA 3877938 c.570C>T synonymous_variant 0.83 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.8 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.78 rifampicin
rpoA 3877974 c.534G>C synonymous_variant 0.82 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.8 rifampicin
rpoA 3877992 c.516C>G synonymous_variant 0.79 rifampicin
rpoA 3877998 c.510G>C synonymous_variant 0.79 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.79 rifampicin
rpoA 3878010 c.498C>G synonymous_variant 0.64 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.6 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.69 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.73 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.73 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.78 rifampicin
rpoA 3878102 p.Val136Ile missense_variant 0.81 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.8 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.8 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.79 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.71 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.77 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.71 rifampicin Uncertain significance
rpoA 3878154 c.354G>C synonymous_variant 0.6 rifampicin
rpoA 3878161 c.345_346delCG frameshift_variant 0.6 rifampicin
rpoA 3878166 c.341_342insGT frameshift_variant 0.6 rifampicin
rpoA 3878175 c.333G>C synonymous_variant 0.67 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.65 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.65 rifampicin
rpoA 3878196 p.Glu104Ala missense_variant 0.65 rifampicin
rpoA 3878199 c.309T>C synonymous_variant 0.65 rifampicin
rpoA 3878217 p.Leu97Val missense_variant 0.62 rifampicin
rpoA 3878241 p.Glu89Asp missense_variant 0.5 rifampicin
rpoA 3878250 c.258C>G synonymous_variant 0.5 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.5 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.53 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.6 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.5 rifampicin
rpoA 3878283 p.Glu75Asp missense_variant 0.47 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.46 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.46 rifampicin
rpoA 3878301 c.207C>G synonymous_variant 0.5 rifampicin
rpoA 3878304 c.204G>C synonymous_variant 0.55 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.55 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.6 rifampicin
clpC1 4038740 c.1965G>C synonymous_variant 0.38 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.47 pyrazinamide
clpC1 4038761 c.1944C>G synonymous_variant 0.41 pyrazinamide
clpC1 4038764 c.1941C>G synonymous_variant 0.41 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.44 pyrazinamide
clpC1 4038794 p.Ser637Thr missense_variant 0.41 pyrazinamide
clpC1 4038808 c.1896_1897insC frameshift_variant 0.42 pyrazinamide
clpC1 4038811 c.1893delT frameshift_variant 0.42 pyrazinamide
clpC1 4038836 c.1869G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.47 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.55 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.6 pyrazinamide
clpC1 4038899 c.1806C>G synonymous_variant 0.62 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.62 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.63 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.63 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.62 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.64 pyrazinamide
clpC1 4038926 c.1779G>C synonymous_variant 0.64 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.7 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.66 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.65 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.62 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.57 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.57 pyrazinamide
clpC1 4038986 p.Asp573Glu missense_variant 0.58 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.6 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.6 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039007 c.1698G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039016 c.1689C>G synonymous_variant 0.55 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.54 pyrazinamide
clpC1 4039025 c.1680C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039034 c.1671C>G synonymous_variant 0.54 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.54 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.61 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.61 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.56 pyrazinamide
clpC1 4039094 c.1611C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.48 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.54 pyrazinamide
clpC1 4039106 c.1599G>T synonymous_variant 0.52 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.52 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.6 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.65 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.65 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.65 pyrazinamide
clpC1 4039181 c.1522_1524delTTGinsCTC synonymous_variant 0.6 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.64 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.5 pyrazinamide
clpC1 4039217 c.1488G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.33 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039406 c.1299G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039427 p.Glu426Asp missense_variant 0.16 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039436 p.Glu423Ala missense_variant 0.18 pyrazinamide
clpC1 4039442 c.1261_1263delCTAinsTTG synonymous_variant 0.18 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039499 c.1206G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.24 pyrazinamide
clpC1 4039574 p.Ala377Ser missense_variant 0.23 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039580 c.1125C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039589 p.Val372Ile missense_variant 0.23 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.44 pyrazinamide
clpC1 4039642 p.Thr355Ala missense_variant 0.52 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039652 p.Thr351Ser missense_variant 0.41 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.68 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.65 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.66 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.59 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.54 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.59 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.59 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.63 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.59 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.6 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.64 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.69 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.55 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.68 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.71 pyrazinamide
clpC1 4039876 p.Asn277Asp missense_variant 0.68 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039896 p.Lys270Arg missense_variant 0.44 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.48 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.5 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.45 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.46 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.46 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039994 p.Glu237Asn missense_variant 0.61 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.61 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.62 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.62 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.68 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.67 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.67 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.71 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.71 pyrazinamide
clpC1 4040090 c.615T>G synonymous_variant 0.65 pyrazinamide
clpC1 4040107 p.Val200Ile missense_variant 0.33 pyrazinamide
clpC1 4040108 c.597G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040117 c.588A>G synonymous_variant 0.36 pyrazinamide
clpC1 4040123 p.Glu194Ser missense_variant 0.19 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040153 c.552A>G synonymous_variant 0.11 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.64 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.8 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.7 pyrazinamide
clpC1 4040426 c.279T>C synonymous_variant 0.7 pyrazinamide
clpC1 4040486 c.219G>C synonymous_variant 0.8 pyrazinamide
clpC1 4040495 c.210C>G synonymous_variant 0.8 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.7 pyrazinamide
ethR 4327661 p.Glu38Val missense_variant 0.18 ethionamide