TB-Profiler result

Run: ERR9786656

Summary

Run ID: ERR9786656

Sample name:

Date: 2024-03-27T01:21:31.563564

Number of reads: 5192292

Percentage reads mapped: 85.46

Median coverage: 207.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Sensitive


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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.96
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.99
lineage4 Euro-American None 0.94
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7661 c.360C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8990 c.1689C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9365 c.2064G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
fgd1 491007 c.225G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491013 c.231C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491022 c.240C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>A synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491097 c.315G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491591 p.Lys270Met missense_variant 0.9 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575659 c.312A>G synonymous_variant 0.16 ethionamide
isoniazid
mshA 575674 c.327G>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575679 p.Asn111Ser missense_variant 0.83 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575683 c.336G>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575692 c.345G>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.18 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.19 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.21 ethionamide
isoniazid
mshA 575833 c.486C>T synonymous_variant 0.21 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575845 c.498C>G synonymous_variant 0.21 ethionamide
isoniazid
Rv0565c 657269 p.Ser68Pro missense_variant 0.91 ethionamide Uncertain significance
hadA 732389 p.Ser154Thr missense_variant 0.15 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.15 isoniazid
nusG 734460 c.207G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.19 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.2 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.2 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.17 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.2 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.2 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.21 rifampicin
nusG 734646 c.393G>A synonymous_variant 0.2 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.2 rifampicin
nusG 734658 c.405A>G synonymous_variant 0.2 rifampicin Not assoc w R
nusG 734661 c.408A>C synonymous_variant 0.19 rifampicin
nusG 734664 c.411T>G synonymous_variant 0.19 rifampicin
nusG 734673 c.420A>G synonymous_variant 0.2 rifampicin
nusG 734679 c.426C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734680 c.427_429delGCCinsAG frameshift_variant&missense_variant 0.2 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.21 rifampicin
nusG 734709 c.456T>G synonymous_variant 0.2 rifampicin
nusG 734715 c.462G>C synonymous_variant 0.18 rifampicin
nusG 734718 c.465G>C synonymous_variant 0.18 rifampicin
nusG 734719 p.Ser156Thr missense_variant 0.19 rifampicin
nusG 734726 p.Arg158Lys missense_variant 0.2 rifampicin
nusG 734733 c.480T>C synonymous_variant 0.2 rifampicin
nusG 734750 p.Ser166Thr missense_variant 0.19 rifampicin
nusG 734757 c.504T>C synonymous_variant 0.19 rifampicin
nusG 734771 p.Ala173Val missense_variant 0.17 rifampicin
nusG 734787 c.534T>C synonymous_variant 0.16 rifampicin
nusG 734792 p.Val180Ala missense_variant 0.15 rifampicin
nusG 734794 p.Val181Ile missense_variant 0.15 rifampicin Uncertain significance
rpoB 760085 c.279C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760115 c.309C>T synonymous_variant 0.86 rifampicin Not assoc w R
rpoB 760181 c.375T>A synonymous_variant 0.15 rifampicin
rpoB 760196 c.390C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.2 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.22 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.21 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.21 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.21 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.19 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.19 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.18 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760463 c.657C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.18 rifampicin
rpoB 760496 c.690G>A synonymous_variant 0.23 rifampicin
rpoB 760520 c.714C>G synonymous_variant 0.17 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.17 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.15 rifampicin
rpoB 760547 c.741G>T synonymous_variant 0.16 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.19 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.19 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.18 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.17 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.17 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.17 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.19 rifampicin
rpoB 760784 c.978G>C synonymous_variant 0.2 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.21 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.23 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.21 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.21 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.24 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.24 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Thr missense_variant 0.23 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.24 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.24 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.23 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.22 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.28 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.28 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.27 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.28 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.28 rifampicin
rpoB 761213 c.1407G>T synonymous_variant 0.27 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.17 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.15 rifampicin
rpoB 761465 c.1659G>C synonymous_variant 0.15 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.18 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.16 rifampicin
rpoB 761561 c.1755C>G synonymous_variant 0.16 rifampicin
rpoB 761579 c.1773G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761948 c.2142G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.21 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.2 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.22 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.25 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.25 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.25 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.25 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.25 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.22 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.22 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.22 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.22 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.2 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.19 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.16 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.16 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.23 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.21 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.21 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.21 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.19 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.15 rifampicin
rpoC 763486 c.117T>G synonymous_variant 0.2 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>T synonymous_variant 0.3 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.29 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.29 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.25 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.25 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.25 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.25 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.22 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.21 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.2 rifampicin
rpoC 763801 c.432C>T synonymous_variant 0.21 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.2 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.19 rifampicin
rpoC 763853 c.484_486delGTCinsAT frameshift_variant&missense_variant 0.19 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.19 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.19 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.19 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.18 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.18 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.17 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.17 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763933 c.564C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.2 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763969 c.600C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763972 c.603C>T synonymous_variant 0.2 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.16 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.16 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.18 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.18 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.18 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.16 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.16 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.15 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.17 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>T synonymous_variant 0.15 rifampicin
rpoC 764213 p.Arg282Lys missense_variant 0.15 rifampicin Uncertain significance
rpoC 764254 c.885G>C synonymous_variant 0.17 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.18 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.18 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.18 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764287 c.918C>T synonymous_variant 0.19 rifampicin
rpoC 764293 c.924G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.17 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.17 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>A synonymous_variant 0.21 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 764419 c.1050C>G synonymous_variant 0.2 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.17 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.17 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.17 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.2 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.19 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.18 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.19 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.22 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764902 c.1533C>T synonymous_variant 0.16 rifampicin
rpoC 764915 c.1546C>T synonymous_variant 0.17 rifampicin
rpoC 764932 c.1563C>G synonymous_variant 0.16 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.17 rifampicin
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765499 c.2130C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.18 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.19 rifampicin
rpoC 765550 c.2181C>T synonymous_variant 0.18 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.18 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.18 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.18 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.18 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.16 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766010 p.Ser881Thr missense_variant 0.14 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.16 rifampicin
rpoC 766061 p.Val898Ile missense_variant 0.17 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.16 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766321 c.2952C>G synonymous_variant 0.15 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.19 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.16 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.16 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.16 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.18 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.17 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.17 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.18 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.16 rifampicin
rpoC 766462 c.3093G>T synonymous_variant 0.17 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.16 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.16 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.17 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.17 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.18 rifampicin
rpoC 766540 c.3171C>T synonymous_variant 0.17 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.16 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.17 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.16 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.15 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.18 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.2 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.22 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.22 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.23 rifampicin
rpoC 766693 c.3324C>T synonymous_variant 0.21 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.24 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.23 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.21 rifampicin
rpoC 766801 c.3432C>A synonymous_variant 0.16 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.22 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.23 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.23 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.24 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.21 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.23 rifampicin
rpoC 766978 c.3609C>A synonymous_variant 0.24 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.26 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.25 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.22 rifampicin
rpoC 767149 c.3780C>A synonymous_variant 0.21 rifampicin
rpoC 767164 c.3795C>T synonymous_variant 0.21 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.19 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781736 c.177T>C synonymous_variant 0.16 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.18 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.17 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.18 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.19 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.19 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.2 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.19 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.19 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.18 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.17 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.17 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.17 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.17 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.15 streptomycin
fbiC 1304853 c.1923C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304880 c.1950C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304944 c.2014C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304955 c.2025G>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304961 c.2031C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304995 c.2065T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305014 p.Thr695Ser missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305045 c.2115A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305051 c.2121G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1473966 n.309T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474036 n.379G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474040 n.383G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475201 n.1544G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.16 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.15 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
inhA 1674601 p.Leu134Thr missense_variant 0.16 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.17 ethionamide
isoniazid
rpsA 1833667 c.126C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1833793 c.252C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833844 c.303C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.17 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.17 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.16 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.17 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2156607 c.-497delA upstream_gene_variant 1.0 isoniazid Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518076 c.-39C>T upstream_gene_variant 0.9 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.19 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.17 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.16 isoniazid
kasA 2518585 c.471G>A synonymous_variant 0.16 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.17 isoniazid
kasA 2518591 c.477G>T synonymous_variant 0.18 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.19 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.18 isoniazid
kasA 2518618 c.504G>C synonymous_variant 0.2 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.21 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.21 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.21 isoniazid
kasA 2518645 c.531G>C synonymous_variant 0.21 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.23 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.23 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.24 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.23 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.24 isoniazid
kasA 2518705 c.591T>G synonymous_variant 0.23 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.22 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.24 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.25 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.21 isoniazid
kasA 2518759 c.645C>G synonymous_variant 0.2 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.19 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.19 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.18 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.17 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.16 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.16 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.16 isoniazid
kasA 2518837 c.723G>A synonymous_variant 0.16 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.16 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.15 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.16 isoniazid
folC 2746551 p.Ile350Leu missense_variant 0.18 para-aminosalicylic_acid
folC 2746564 c.1035A>G synonymous_variant 0.17 para-aminosalicylic_acid
Rv2477c 2782981 c.1062G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.21 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783086 c.957C>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>A synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783107 c.936G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.2 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783341 c.702C>A synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783344 c.699C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.616_618delCCCinsGG frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783432 c.610_611delAGinsTC synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783434 c.609C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783437 c.606G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783629 c.414C>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783695 c.348C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2680 2996034 c.-71G>A upstream_gene_variant 0.16 capreomycin Uncertain significance
Rv2680 2996136 p.Ser11Asn missense_variant 0.23 capreomycin
thyX 3067442 c.504C>T synonymous_variant 0.15 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624125 c.786A>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624133 c.778A>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624166 p.Met249Leu missense_variant 0.17 bedaquiline
rifampicin
lpqB 3624179 c.732C>G synonymous_variant 0.16 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625656 c.958T>C synonymous_variant 0.2 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.18 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625768 c.-858G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625786 c.-876C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625797 p.Val273Met missense_variant 0.15 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625852 c.762A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625855 c.759G>A synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625888 c.726G>A synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626119 c.495C>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626125 c.489C>G synonymous_variant 0.19 bedaquiline
rifampicin
mtrB 3626134 c.480C>G synonymous_variant 0.19 bedaquiline
rifampicin
mtrB 3626155 c.457_459delGCGinsTC frameshift_variant&missense_variant 0.17 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626158 p.Asn152Ser missense_variant 0.16 bedaquiline
rifampicin
mtrB 3626170 c.444T>C synonymous_variant 0.16 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627023 c.-410C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627056 c.294C>T synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627065 c.-452G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627170 c.-557C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627221 c.129C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877983 c.525C>A synonymous_variant 0.16 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.15 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.15 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>G synonymous_variant 0.18 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.19 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.22 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Ala missense_variant 0.22 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>T synonymous_variant 0.19 rifampicin
rpoA 3878307 c.201C>G synonymous_variant 0.18 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.19 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.17 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.16 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.16 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.15 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.15 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.16 rifampicin
rpoA 3878672 c.-165A>T upstream_gene_variant 0.16 rifampicin
rpoA 3878683 c.-176G>C upstream_gene_variant 0.19 rifampicin
rpoA 3878698 c.-191A>G upstream_gene_variant 0.18 rifampicin
rpoA 3878701 c.-194C>G upstream_gene_variant 0.18 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.21 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.18 rifampicin
rpoA 3878734 c.-229_-227delATCinsGG upstream_gene_variant 0.17 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.17 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.17 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.17 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.21 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.18 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.19 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.2 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.17 rifampicin
rpoA 3878836 c.-331_-329delAAGinsGGC upstream_gene_variant 0.17 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.22 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.21 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878935 c.-428C>T upstream_gene_variant 0.2 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.21 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878953 c.-446C>T upstream_gene_variant 0.22 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.22 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.23 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.17 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.17 rifampicin
rpoA 3879028 c.-521C>T upstream_gene_variant 0.17 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.17 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.15 rifampicin
clpC1 4038388 c.2317T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.17 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.21 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.19 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.19 pyrazinamide
clpC1 4038458 c.2247G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038461 c.2244G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038486 p.Gly740Thr missense_variant 0.19 pyrazinamide
clpC1 4038488 c.2217C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038494 c.2211G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038498 p.Ser736Asn missense_variant 0.21 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.2 pyrazinamide
clpC1 4038533 p.Arg724Lys missense_variant 0.19 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.15 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.15 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038794 c.1911C>T synonymous_variant 0.21 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.22 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.21 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039094 c.1611C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039283 c.1422C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039338 p.Thr456Lys missense_variant 0.14 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039466 c.1239T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.2 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039601 c.1104G>A synonymous_variant 0.2 pyrazinamide
clpC1 4039610 c.1095G>T synonymous_variant 0.21 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAC frameshift_variant&missense_variant 0.16 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.16 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.16 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040030 c.675C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040171 c.534C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAC frameshift_variant&missense_variant 0.16 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.16 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.19 pyrazinamide
clpC1 4040243 c.462C>A synonymous_variant 0.18 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040278 p.Ser143Thr missense_variant 0.16 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040284 c.421C>T synonymous_variant 0.17 pyrazinamide
clpC1 4040300 c.405C>T synonymous_variant 0.2 pyrazinamide
clpC1 4040315 c.390G>A synonymous_variant 0.2 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.18 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040408 c.297C>T synonymous_variant 0.17 pyrazinamide
clpC1 4040411 c.294T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040462 c.243C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040477 c.228G>A synonymous_variant 0.17 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.17 pyrazinamide
clpC1 4040486 c.219G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>T synonymous_variant 0.15 pyrazinamide
glpK 4138547 c.1209C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138580 c.1176C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138601 c.1155G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138643 c.1113A>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138655 c.1101G>A synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138667 c.1089G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138682 c.1074C>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138685 c.1071C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138695 p.Pro354Asp missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>A synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138715 c.1041G>A synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138799 c.957T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138805 c.951C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239298 c.-565C>T upstream_gene_variant 0.99 ethambutol Not assoc w R
embC 4240780 c.918T>C synonymous_variant 0.21 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.21 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.21 ethambutol
embC 4240798 c.936C>T synonymous_variant 0.19 ethambutol
embC 4240813 p.Phe317Leu missense_variant 0.2 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.19 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.18 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.22 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.23 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.22 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.2 ethambutol
embC 4240886 p.Ile342Val missense_variant 0.19 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.23 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.22 ethambutol
embC 4240910 p.Ala350Leu missense_variant 0.22 ethambutol
embC 4240921 c.1059C>G synonymous_variant 0.21 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.22 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.24 ethambutol
embC 4240939 c.1077C>A synonymous_variant 0.24 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.2 ethambutol
embC 4240957 c.1095C>G synonymous_variant 0.2 ethambutol
embC 4240966 c.1104G>C synonymous_variant 0.2 ethambutol
embC 4240972 c.1110C>A synonymous_variant 0.18 ethambutol
embC 4240978 c.1116G>A synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4240979 p.Thr373Gln missense_variant 0.17 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.17 ethambutol
embC 4240987 c.1125G>C synonymous_variant 0.17 ethambutol
embC 4240990 c.1128A>G synonymous_variant 0.17 ethambutol
embC 4241002 c.1140G>C synonymous_variant 0.18 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.19 ethambutol
embC 4241023 c.1161T>C synonymous_variant 0.21 ethambutol
embC 4241026 c.1164C>T synonymous_variant 0.2 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.2 ethambutol
embC 4241053 c.1191G>T synonymous_variant 0.21 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.18 ethambutol
embC 4241086 c.1224G>C synonymous_variant 0.18 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.99 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
embA 4245377 c.2145T>G synonymous_variant 0.17 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin