TB-Profiler result

Run: SRR7535047
Summary

Run ID: SRR7535047

Sample name:

Date: 2024-03-26T17:30:44.081854

Number of reads: 4539526

Percentage reads mapped: 35.1

Median coverage: 68.0

Strain: lineage4.6.1.1

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.6 Euro-American None 0.99
lineage4 Euro-American None 1.0
lineage4.6.1.1 Euro-American RD724 1.0
lineage4.6.1 Euro-American (Uganda) RD724 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Leu464Met Mutation from literature
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.799C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761196 p.Leu464Met missense_variant 0.18 rifampicin Mutation from literature
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance Mutation from literature
amikacin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.78 capreomycin Assoc w R
kanamycin Assoc w R
amikacin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7539 p.Thr80Ala missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rpoB 761201 c.1395G>A synonymous_variant 0.26 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.43 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761252 c.1446C>G synonymous_variant 0.3 rifampicin
rpoB 761255 c.1449T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761276 c.1470G>C synonymous_variant 0.25 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>A synonymous_variant 0.28 rifampicin
rpoB 761955 p.Ile717Phe missense_variant 0.3 rifampicin
rpoB 761961 p.Pro719Ser missense_variant 0.35 rifampicin Uncertain significance
rpoB 761973 p.His723Tyr missense_variant 0.43 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.4 rifampicin
rpoB 762009 p.Leu735Met missense_variant 0.39 rifampicin
rpoB 762014 c.2208C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762015 c.2209_2211delGAAinsCG frameshift_variant&missense_variant 0.33 rifampicin
rpoB 762020 p.Glu738Asp missense_variant 0.33 rifampicin
rpoB 762030 p.Thr742Ser missense_variant 0.33 rifampicin
rpoB 762047 c.2241G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>T synonymous_variant 0.22 rifampicin
rpoB 762194 c.2388G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.32 rifampicin
rpoB 762224 c.2418C>T synonymous_variant 0.34 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.31 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.29 rifampicin
rpoB 762273 p.Ala823Ser missense_variant 0.26 rifampicin
rpoB 762278 c.2472C>T synonymous_variant 0.19 rifampicin
rpoB 762855 p.Val1017Ile missense_variant 0.35 rifampicin
rpoB 762858 p.Thr1018Ser missense_variant 0.36 rifampicin
rpoB 762863 c.3057T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762876 c.3070_3072delATCinsCG frameshift_variant&missense_variant 0.35 rifampicin
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.34 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 762917 c.-453C>A upstream_gene_variant 0.45 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>A synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 762980 c.-390T>C upstream_gene_variant 0.48 rifampicin
rpoC 762983 c.-387C>T upstream_gene_variant 0.46 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.45 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763005 p.Cys1067Gly missense_variant 0.26 rifampicin Uncertain significance
rpoC 763013 c.-357C>A upstream_gene_variant 0.17 rifampicin
rpoB 763014 p.Met1070Leu missense_variant 0.17 rifampicin
rpoB 763017 p.Gln1071Glu missense_variant 0.22 rifampicin
rpoC 763022 c.-348C>A upstream_gene_variant 0.24 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 0.26 rifampicin Not assoc w R
rpoB 763040 c.3234C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763052 c.-318G>C upstream_gene_variant 0.23 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.24 rifampicin
rpoB 763075 p.Thr1090Ile missense_variant 0.27 rifampicin
rpoB 763077 p.Val1091Pro missense_variant 0.29 rifampicin
rpoB 763094 c.3288G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763118 p.Glu1104Asp missense_variant 0.17 rifampicin
rpoB 763122 c.3316_3318delATCinsCG frameshift_variant&missense_variant 0.15 rifampicin
rpoB 763128 c.3322_3324delGAGinsAT frameshift_variant&missense_variant 0.14 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763462 c.93G>C synonymous_variant 0.38 rifampicin
rpoC 763483 c.114G>C synonymous_variant 0.58 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763534 c.165T>C synonymous_variant 0.81 rifampicin
rpoC 763537 c.168C>T synonymous_variant 0.81 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763597 c.228G>A synonymous_variant 0.67 rifampicin
rpoC 763606 c.237C>T synonymous_variant 0.65 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 763630 c.261G>C synonymous_variant 0.61 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763672 c.303C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.56 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.48 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.42 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.34 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.32 rifampicin
rpoC 763772 p.Val135Met missense_variant 0.27 rifampicin
rpoC 764314 c.945C>T synonymous_variant 0.28 rifampicin
rpoC 764317 c.948C>G synonymous_variant 0.29 rifampicin
rpoC 764318 c.949_951delGTCinsAT frameshift_variant&missense_variant 0.28 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.45 rifampicin
rpoC 764371 c.1002G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.36 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.32 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.15 rifampicin
rpoC 764458 c.1089G>T synonymous_variant 0.33 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764470 c.1101C>G synonymous_variant 0.5 rifampicin
rpoC 764498 p.Ser377Ala missense_variant 0.56 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.59 rifampicin
rpoC 764507 p.Ala380Ser missense_variant 0.6 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.57 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.53 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.52 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.66 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781748 c.189C>G synonymous_variant 0.13 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.13 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.26 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.46 streptomycin
rpsL 781796 p.Met79Ile missense_variant 0.47 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.47 streptomycin
rpsL 781811 c.252C>A synonymous_variant 0.47 streptomycin
rpsL 781817 c.258G>A synonymous_variant 0.44 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.46 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.33 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.32 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.31 streptomycin Not assoc w R - Interim
rpsL 781851 c.292_294delATCinsGG frameshift_variant&missense_variant 0.18 streptomycin Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471967 n.122G>A non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471972 n.127T>C non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471979 n.134T>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471980 n.135G>T non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1471981 n.136C>G non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472092 n.247C>T non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472107 n.262A>G non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472120 n.275G>A non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472223 n.378C>G non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472225 n.380C>G non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472228 n.383G>C non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>C non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472279 n.434T>G non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472337 n.492C>T non_coding_transcript_exon_variant 0.45 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472380 n.535G>A non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472427 n.582T>G non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472484 n.639A>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>A non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472506 n.661A>T non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472572 n.727T>A non_coding_transcript_exon_variant 0.88 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>A non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.61 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.63 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472714 n.869A>T non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472991 n.1146G>A non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473047 n.1202C>T non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473094 n.1249T>G non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>G non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473147 n.1302G>T non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473164 n.1319C>A non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445_1449delCGGGAinsTGTGGG non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1473290 n.1445_1449delCGGGAinsTGTGGGG non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1473834 n.177_179delGGAinsTGGG non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473884 n.227C>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1473888 n.231T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473889 n.232G>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1473922 n.265A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474141 n.484G>C non_coding_transcript_exon_variant 0.12 capreomycin
linezolid
rrl 1474142 n.485C>G non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474155 n.498G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1474171 n.514C>G non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474292 n.636_651delTCCTCTCCGGAGGAGG non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474310 n.653_654insTGG non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474359 n.702C>A non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474476 n.819C>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474483 n.826C>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474496 n.839C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474520 n.863A>C non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474558 n.901G>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474584 n.927C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474633 n.977_981delTCACC non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1474640 n.983_984insTTTCT non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1052_1053delGTinsAGGA non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474711 n.1054G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474715 n.1061delA non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.53 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.76 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474927 n.1271delC non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475088 n.1431A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475109 n.1452C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475508 n.1851A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475518 n.1861A>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475532 n.1875A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475571 n.1914A>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475589 n.1932G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid Uncertain significance
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475696 n.2039T>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475703 n.2046A>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101_2102delACinsGAA non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475761 n.2104C>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2107_2109delAAG non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475769 n.2112_2113insTC non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1475871 n.2214T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475963 n.2306G>A non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.54 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475990 n.2333G>A non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.76 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.76 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.79 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.74 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.68 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1476519 n.2862C>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.78 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>A non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476603 n.2946G>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.63 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833997 c.456G>T synonymous_variant 0.23 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834025 p.Gln162Ser missense_variant 0.24 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.27 pyrazinamide
rpsA 1834040 p.Lys167Gln missense_variant 0.26 pyrazinamide
rpsA 1834043 p.Glu168Gln missense_variant 0.28 pyrazinamide
rpsA 1834046 p.Ile169Val missense_variant 0.27 pyrazinamide
rpsA 1834066 c.525G>A synonymous_variant 0.26 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834240 c.699T>A synonymous_variant 0.14 pyrazinamide
rpsA 1834243 c.702G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834286 c.745_746delTCinsAG synonymous_variant 0.12 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>G synonymous_variant 0.22 pyrazinamide
rpsA 1834360 c.819G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.44 pyrazinamide
rpsA 1834395 p.Arg285Gln missense_variant 0.49 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834416 p.Ala292Val missense_variant 0.4 pyrazinamide
rpsA 1834423 c.882G>A synonymous_variant 0.49 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.49 pyrazinamide Uncertain significance
rpsA 1834456 c.915T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.51 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.48 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.38 pyrazinamide
rpsA 1834486 p.Glu315Asp missense_variant 0.32 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.26 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834516 c.975G>A synonymous_variant 0.2 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 0.96 capreomycin Not assoc w R
PPE35 2170048 p.Leu189Val missense_variant 0.33 pyrazinamide
PPE35 2170053 p.Thr187Ser missense_variant 0.31 pyrazinamide
Rv1979c 2222370 c.795G>A synonymous_variant 1.0 clofazimine
bedaquiline
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv2681 2996876 c.138A>C synonymous_variant 1.0 capreomycin Not assoc w R
Rv2752c 3065728 p.Ala155Val missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
whiB7 3569029 c.-350A>G upstream_gene_variant 1.0 streptomycin Uncertain significance
amikacin Uncertain significance
kanamycin Not assoc w R
clpC1 4039958 c.747G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039978 p.Lys243Glu missense_variant 0.36 pyrazinamide
clpC1 4039982 p.Thr241Ile missense_variant 0.33 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.41 pyrazinamide
clpC1 4039997 c.708C>T synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4040001 p.His235Arg missense_variant 0.46 pyrazinamide
clpC1 4040009 c.696C>T synonymous_variant 0.52 pyrazinamide
clpC1 4040015 c.690G>T synonymous_variant 0.55 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.58 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.63 pyrazinamide
clpC1 4040063 c.642G>C synonymous_variant 0.51 pyrazinamide Not assoc w R - Interim
clpC1 4040066 c.639G>C synonymous_variant 0.44 pyrazinamide
clpC1 4040069 c.636G>T synonymous_variant 0.45 pyrazinamide
clpC1 4040081 c.624C>G synonymous_variant 0.31 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040090 c.615T>G synonymous_variant 0.27 pyrazinamide
clpC1 4040324 c.381G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040333 c.372G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.24 pyrazinamide
clpC1 4040360 c.345G>A synonymous_variant 0.25 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.24 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.19 pyrazinamide
glpK 4139670 p.Cys29Tyr missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Not assoc w R
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4328329 c.-856C>G upstream_gene_variant 1.0 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin