TB-Profiler result

Run: SRR1049582
Summary

Run ID: SRR1049582

Sample name:

Date: 2024-10-04T18:03:38.425582

Number of reads: 3388012

Percentage reads mapped: 71.68

Median coverage: 50.0

Strain: lineage4.6.1.2

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.6 Euro-American None 0.97
lineage4.6.1.2 Euro-American RD724 0.99
lineage4 Euro-American None 1.0
lineage4.6.1 Euro-American (Uganda) RD724 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
rpoC p.Gly332Arg Uncertain significance Mutation from literature
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin rpsL p.Lys88Arg Assoc w R
rrs n.799C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide ethA p.Trp455* Assoc w R
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 0.89 rifampicin Assoc w R
rpoC 764363 p.Gly332Arg missense_variant 0.77 rifampicin Uncertain significance Mutation from literature
rpsL 781822 p.Lys88Arg missense_variant 0.49 streptomycin Assoc w R
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.7 amikacin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.49 amikacin Assoc w R
capreomycin Assoc w R
kanamycin Assoc w R
katG 2155168 p.Ser315Thr missense_variant 0.98 isoniazid Assoc w R High-level resistance
ethA 4326110 p.Trp455* stop_gained 0.94 ethionamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7539 p.Thr80Ala missense_variant 0.96 levofloxacin Not assoc w R
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9276 c.1975C>T synonymous_variant 0.96 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rpoB 760206 p.Ile134Val missense_variant 0.17 rifampicin
rpoB 760212 p.Asn136Tyr missense_variant 0.2 rifampicin
rpoB 760216 p.Asn137Thr missense_variant 0.2 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760241 c.435G>C synonymous_variant 0.2 rifampicin
rpoB 760244 c.438G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760263 p.Met153Leu missense_variant 0.21 rifampicin
rpoB 760270 p.Thr155Ser missense_variant 0.22 rifampicin
rpoB 760275 p.Lys157Arg missense_variant 0.22 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762920 c.-450C>G upstream_gene_variant 0.36 rifampicin
rpoB 762923 c.3117C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.28 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762980 c.-390T>C upstream_gene_variant 0.18 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763480 c.111C>G synonymous_variant 0.33 rifampicin
rpoC 763483 c.114G>C synonymous_variant 0.34 rifampicin
rpoC 763486 c.117T>G synonymous_variant 0.34 rifampicin
rpoC 763504 c.135C>G synonymous_variant 0.41 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.42 rifampicin
rpoC 763528 c.159G>T synonymous_variant 0.52 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.52 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.52 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.52 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763622 p.Ala85Ser missense_variant 0.48 rifampicin Uncertain significance
rpoC 763630 c.261G>C synonymous_variant 0.47 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763642 c.273G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763686 p.Tyr106Phe missense_variant 0.5 rifampicin
rpoC 763696 c.327T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.44 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.44 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.39 rifampicin
rpoC 764326 c.957G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764338 p.Glu323Asp missense_variant 0.22 rifampicin
rpoC 764383 c.1014C>G synonymous_variant 0.21 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.18 rifampicin
rpoC 764419 c.1050C>G synonymous_variant 0.16 rifampicin
rpoC 764461 c.1092A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764491 c.1122G>C synonymous_variant 0.14 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.14 rifampicin
rpoC 764507 p.Ala380Ser missense_variant 0.23 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.41 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>G synonymous_variant 0.41 rifampicin
rpoC 764548 c.1179G>C synonymous_variant 0.41 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.41 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764573 p.Leu402Ile missense_variant 0.4 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.41 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.41 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.46 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764706 p.Leu446Gln missense_variant 0.54 rifampicin Uncertain significance
rpoC 764716 c.1347G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.36 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.29 rifampicin
rpoC 764810 p.Pro481Thr missense_variant 0.81 rifampicin Uncertain significance
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781748 c.189C>G synonymous_variant 0.15 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.38 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.41 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>G synonymous_variant 0.43 streptomycin
rpsL 781796 p.Met79Ile missense_variant 0.45 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.46 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.48 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.47 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.47 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.48 streptomycin Not assoc w R - Interim
rpsL 781838 c.279G>C synonymous_variant 0.48 streptomycin
rpsL 781856 c.297C>T synonymous_variant 0.3 streptomycin Not assoc w R - Interim
rpsL 781859 c.300T>C synonymous_variant 0.24 streptomycin Not assoc w R - Interim
rpsL 781860 p.Ser101Ala missense_variant 0.24 streptomycin Uncertain significance
rplC 800630 c.-179G>C upstream_gene_variant 0.25 linezolid
rplC 800632 c.-177_-176delATinsTC upstream_gene_variant 0.25 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.24 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.24 linezolid
rplC 800651 c.-158G>T upstream_gene_variant 0.23 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.23 linezolid
rplC 800667 c.-142_-140delTCGinsAGC upstream_gene_variant 0.27 linezolid
rplC 800672 c.-137G>C upstream_gene_variant 0.26 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.28 linezolid
rplC 800703 c.-106_-104delTTGinsCTC upstream_gene_variant 0.22 linezolid
fbiC 1303391 p.Arg154His missense_variant 1.0 pretomanid
delamanid
clofazimine
embR 1416410 p.Leu313Arg missense_variant 0.91 ethambutol Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.52 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472583 n.738T>C non_coding_transcript_exon_variant 0.83 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.66 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472674 n.829T>C non_coding_transcript_exon_variant 0.65 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472685 n.840G>A non_coding_transcript_exon_variant 0.64 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472701 n.856T>A non_coding_transcript_exon_variant 0.74 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.88 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.83 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.68 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473287 n.1442_1445delCCTCinsTCTTT non_coding_transcript_exon_variant 0.46 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473292 n.1447G>A non_coding_transcript_exon_variant 0.45 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473294 n.1449A>G non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473788 n.131A>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473797 n.140G>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473845 n.188G>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474290 n.633T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474291 n.635_645delTTCCTCTCCGG non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474305 n.648G>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474308 n.653_654delTG non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474381 n.724T>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474406 n.749T>C non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474450 n.793T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474466 n.809G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474476 n.819C>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474483 n.826C>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474529 n.872A>G non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474540 n.883T>C non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.72 capreomycin
linezolid
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474558 n.901G>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474624 n.967G>C non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474660 n.1003G>A non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474690 n.1033C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1474725 n.1068C>G non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.67 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.67 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474801 n.1144G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474934 n.1277C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474946 n.1289C>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475499 n.1842C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475508 n.1851A>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid Uncertain significance
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475752 n.2095_2098delCCGTinsGGG non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475757 n.2100A>C non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475759 n.2102C>G non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1475768 n.2111_2112delGTinsC non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475776 n.2119G>C non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.78 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.84 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.84 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.84 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476235 n.2578A>G non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.68 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476279 n.2622G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.82 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.8 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.76 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.68 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.64 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.6 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476668 n.3011C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833646 c.105T>C synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
rpsA 1833649 c.108C>T synonymous_variant 0.49 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.58 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.68 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.65 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.65 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.63 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.62 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.6 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.57 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.52 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.51 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.49 pyrazinamide
rpsA 1833763 c.222C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833769 c.228C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833770 p.Asn77Gly missense_variant 0.2 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.31 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833893 p.Ala118Lys missense_variant 0.23 pyrazinamide
rpsA 1833896 p.Leu119Ile missense_variant 0.23 pyrazinamide
rpsA 1833905 p.Lys122Glu missense_variant 0.23 pyrazinamide
rpsA 1833912 p.Glu124Gly missense_variant 0.24 pyrazinamide
rpsA 1833915 p.Ala125Val missense_variant 0.24 pyrazinamide Uncertain significance
rpsA 1833921 p.Lys127Thr missense_variant 0.24 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.48 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.52 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.58 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.65 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.67 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.68 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.68 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.73 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.72 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.73 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.76 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.56 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.51 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834135 c.594G>C synonymous_variant 0.12 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.45 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.44 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834240 c.699T>G synonymous_variant 0.48 pyrazinamide
rpsA 1834243 c.702G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.54 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.6 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.56 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.53 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.51 pyrazinamide
rpsA 1834307 p.Asp256Gln missense_variant 0.51 pyrazinamide
rpsA 1834318 c.777C>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
rpsA 1834327 c.786G>C synonymous_variant 0.55 pyrazinamide
rpsA 1834330 c.789C>G synonymous_variant 0.52 pyrazinamide
rpsA 1834340 p.Met267Phe missense_variant 0.44 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834427 p.Ile296Val missense_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834432 c.891G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCTC synonymous_variant 0.34 pyrazinamide
rpsA 1834456 c.915T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834486 p.Glu315Asp missense_variant 0.35 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834524 p.Glu328Val missense_variant 0.27 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834538 p.Val333Met missense_variant 0.14 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv2752c 3065920 p.Pro91Leu missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
ald 3087593 p.Met258Ile missense_variant 1.0 cycloserine
whiB7 3569029 c.-350A>G upstream_gene_variant 0.98 kanamycin Not assoc w R
amikacin Uncertain significance
streptomycin Uncertain significance
clpC1 4039850 c.855T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039871 c.834C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039875 p.Asn277Arg missense_variant 0.33 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039925 c.780C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.28 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039945 p.Ser254Ala missense_variant 0.28 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.26 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.29 pyrazinamide
clpC1 4040000 p.His235Arg missense_variant 0.23 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040010 p.Ala232Asp missense_variant 0.24 pyrazinamide Uncertain significance
clpC1 4040015 c.690G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.33 pyrazinamide
glpK 4139670 p.Cys29Tyr missense_variant 0.92 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
embA 4245055 p.Thr608Asn missense_variant 0.98 ethambutol Uncertain significance
ubiA 4269317 p.Ser173Ala missense_variant 0.61 ethambutol Uncertain significance
ethR 4328171 p.Val208Ala missense_variant 0.95 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin