Run ID: SRR1140724
Sample name:
Date: 2024-10-04T22:06:10.173492
Number of reads: 753505
Percentage reads mapped: 26.35
Median coverage: 13.0
Strain: lineage2.2.1
Spoligotype:
Drug-resistance: Other
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage2 | East-Asian | RD105 | 0.98 |
lineage2.2.1 | East-Asian (Beijing) | RD105;RD207;RD181 | 0.99 |
lineage2.2 | East-Asian (Beijing) | RD105;RD207 | 0.99 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | embB | p.Met306Ile | Assoc w R | |
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | rrs | n.1401A>G | Assoc w R | |
n.1402C>A | Uncertain significance | Mutation from literature | ||
n.1484G>T | Assoc w R | |||
capreomycin | rrs | n.1401A>G | Assoc w R | |
n.1402C>A | Uncertain significance | Mutation from literature | ||
n.1484G>T | Assoc w R | |||
kanamycin | rrs | n.1401A>G | Assoc w R | |
n.1402C>A | Uncertain significance | Mutation from literature | ||
n.1484G>T | Assoc w R | |||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
rrs | 1473246 | n.1401A>G | non_coding_transcript_exon_variant | 0.24 | amikacin | Assoc w R | |
capreomycin | Assoc w R | ||||||
kanamycin | Assoc w R | ||||||
rrs | 1473247 | n.1402C>A | non_coding_transcript_exon_variant | 0.75 | amikacin | Uncertain significance | Mutation from literature |
capreomycin | Uncertain significance | Mutation from literature | |||||
kanamycin | Uncertain significance | Mutation from literature | |||||
rrs | 1473329 | n.1484G>T | non_coding_transcript_exon_variant | 0.77 | amikacin | Assoc w R | |
capreomycin | Assoc w R | ||||||
kanamycin | Assoc w R | ||||||
embB | 4247431 | p.Met306Ile | missense_variant | 1.0 | ethambutol | Assoc w R |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 8270 | c.969G>C | synonymous_variant | 0.35 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8283 | p.Ile328Leu | missense_variant | 0.44 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 8288 | c.987T>C | synonymous_variant | 0.46 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8294 | c.993T>G | synonymous_variant | 0.48 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8296 | p.Tyr332Phe | missense_variant | 0.48 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8320 | p.Ser340Asn | missense_variant | 0.44 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8324 | c.1023T>C | synonymous_variant | 0.4 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8339 | c.1038A>G | synonymous_variant | 0.47 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8342 | c.1041G>C | synonymous_variant | 0.43 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8366 | c.1065G>C | synonymous_variant | 0.35 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8897 | c.1596T>C | synonymous_variant | 0.46 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8903 | c.1602T>C | synonymous_variant | 0.45 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8906 | c.1605C>G | synonymous_variant | 0.45 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8907 | p.Ser536Ala | missense_variant | 0.45 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8915 | c.1614A>G | synonymous_variant | 0.54 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8939 | c.1638T>C | synonymous_variant | 0.53 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8942 | c.1641G>C | synonymous_variant | 0.51 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8945 | c.1644G>C | synonymous_variant | 0.5 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8946 | c.1645_1647delTTGinsCTT | synonymous_variant | 0.5 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8981 | c.1680G>C | synonymous_variant | 0.43 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8982 | p.Cys561Ser | missense_variant | 0.39 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8996 | c.1695T>C | synonymous_variant | 0.42 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8998 | p.Leu566Trp | missense_variant | 0.4 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 9016 | p.Thr572Asn | missense_variant | 0.32 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R | |||||
Rv0565c | 657142 | p.Arg110His | missense_variant | 1.0 | ethionamide | Uncertain significance |
rpoB | 760917 | c.1111_1113delCGCinsAGG | synonymous_variant | 0.25 | rifampicin | |
rpoB | 760925 | c.1119T>C | synonymous_variant | 0.25 | rifampicin | |
rpoB | 760928 | c.1122G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 760934 | c.1128C>A | synonymous_variant | 0.31 | rifampicin | |
rpoB | 760946 | c.1140A>G | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 760953 | p.Ile383Val | missense_variant | 0.36 | rifampicin | |
rpoB | 760956 | c.1150C>A | synonymous_variant | 0.38 | rifampicin | |
rpoB | 760964 | c.1158C>G | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoB | 760965 | p.Met387Leu | missense_variant | 0.4 | rifampicin | Uncertain significance |
rpoB | 760970 | c.1164G>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoB | 760973 | c.1167G>C | synonymous_variant | 0.42 | rifampicin | |
rpoB | 760991 | c.1185G>C | synonymous_variant | 0.45 | rifampicin | |
rpoB | 761003 | c.1197C>G | synonymous_variant | 0.43 | rifampicin | |
rpoB | 761006 | c.1200C>G | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoB | 761051 | c.1245G>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 761064 | p.Ala420Ser | missense_variant | 0.32 | rifampicin | Uncertain significance |
rpoB | 761070 | p.Lys422Arg | missense_variant | 0.32 | rifampicin | |
rpoB | 761951 | c.2145G>C | synonymous_variant | 0.63 | rifampicin | |
rpoB | 761955 | p.Ile717Phe | missense_variant | 0.63 | rifampicin | |
rpoB | 761972 | c.2166C>T | synonymous_variant | 0.68 | rifampicin | Not assoc w R - Interim |
rpoB | 761980 | p.Tyr725Phe | missense_variant | 0.7 | rifampicin | |
rpoB | 761990 | c.2184G>C | synonymous_variant | 0.62 | rifampicin | Not assoc w R - Interim |
rpoB | 762053 | c.2247T>C | synonymous_variant | 0.58 | rifampicin | Not assoc w R - Interim |
rpoB | 762062 | c.2256T>C | synonymous_variant | 0.53 | rifampicin | Not assoc w R - Interim |
rpoB | 762065 | c.2259T>C | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoB | 762083 | c.2277T>C | synonymous_variant | 0.56 | rifampicin | Not assoc w R - Interim |
rpoB | 762084 | p.Ala760Pro | missense_variant | 0.56 | rifampicin | |
rpoB | 762122 | p.Asp772Glu | missense_variant | 0.76 | rifampicin | |
rpoB | 762131 | c.2325C>G | synonymous_variant | 0.76 | rifampicin | |
rpoB | 762134 | c.2328C>G | synonymous_variant | 0.72 | rifampicin | Not assoc w R - Interim |
rpoB | 762143 | c.2337T>C | synonymous_variant | 0.67 | rifampicin | |
rpoB | 762149 | c.2343G>T | synonymous_variant | 0.59 | rifampicin | Not assoc w R - Interim |
rpoB | 762158 | c.2352G>C | synonymous_variant | 0.67 | rifampicin | Not assoc w R - Interim |
rpoB | 762161 | c.2355C>G | synonymous_variant | 0.69 | rifampicin | |
rpoB | 762176 | c.2370T>G | synonymous_variant | 0.68 | rifampicin | |
rpoB | 762178 | p.Arg791Gln | missense_variant | 0.68 | rifampicin | |
rpoB | 762185 | c.2379G>C | synonymous_variant | 0.69 | rifampicin | Not assoc w R - Interim |
rpoB | 762218 | c.2412T>C | synonymous_variant | 0.7 | rifampicin | |
rpoB | 762233 | c.2427G>C | synonymous_variant | 0.68 | rifampicin | Not assoc w R - Interim |
rpoB | 762254 | c.2448T>C | synonymous_variant | 0.7 | rifampicin | Not assoc w R - Interim |
rpoB | 762257 | c.2451C>G | synonymous_variant | 0.68 | rifampicin | |
rpoB | 762266 | c.2460T>C | synonymous_variant | 0.63 | rifampicin | |
rpoB | 762278 | c.2472C>T | synonymous_variant | 0.6 | rifampicin | |
rpoB | 762293 | c.2487T>C | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoB | 762296 | c.2490G>C | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoB | 762299 | c.2493G>C | synonymous_variant | 0.45 | rifampicin | |
rpoB | 762317 | c.2511A>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 762318 | p.Ser838Thr | missense_variant | 0.31 | rifampicin | |
rpoB | 762329 | c.2523G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 762374 | c.-996G>C | upstream_gene_variant | 0.3 | rifampicin | |
rpoC | 762380 | c.-990T>C | upstream_gene_variant | 0.34 | rifampicin | |
rpoC | 762395 | c.-975G>C | upstream_gene_variant | 0.44 | rifampicin | |
rpoC | 762398 | c.-972T>G | upstream_gene_variant | 0.43 | rifampicin | |
rpoB | 762404 | c.2598T>C | synonymous_variant | 0.55 | rifampicin | Not assoc w R - Interim |
rpoC | 762410 | c.-960T>C | upstream_gene_variant | 0.61 | rifampicin | |
rpoB | 762416 | c.2610A>G | synonymous_variant | 0.63 | rifampicin | Not assoc w R - Interim |
rpoB | 762426 | p.Ser874Gln | missense_variant | 0.64 | rifampicin | |
rpoC | 762434 | c.-936T>C | upstream_gene_variant | 0.72 | rifampicin | |
rpoC | 762443 | c.-927G>C | upstream_gene_variant | 0.76 | rifampicin | |
rpoB | 762470 | c.2664G>C | synonymous_variant | 0.71 | rifampicin | Not assoc w R - Interim |
rpoC | 762491 | c.-879T>G | upstream_gene_variant | 0.68 | rifampicin | |
rpoC | 762503 | c.-867G>C | upstream_gene_variant | 0.57 | rifampicin | |
rpoC | 762509 | c.-861T>G | upstream_gene_variant | 0.5 | rifampicin | |
rpoB | 762510 | p.Ala902Pro | missense_variant | 0.5 | rifampicin | Uncertain significance |
rpoC | 762527 | c.-843G>C | upstream_gene_variant | 0.48 | rifampicin | |
rpoC | 762533 | c.-837T>C | upstream_gene_variant | 0.38 | rifampicin | |
rpoB | 762534 | p.Ile910Val | missense_variant | 0.38 | rifampicin | Uncertain significance |
rpoC | 762537 | c.-833T>C | upstream_gene_variant | 0.36 | rifampicin | |
rpoB | 762543 | p.Thr913Pro | missense_variant | 0.36 | rifampicin | |
rpoC | 762581 | c.-789T>C | upstream_gene_variant | 0.22 | rifampicin | |
rpoC | 762582 | c.-788T>C | upstream_gene_variant | 0.23 | rifampicin | |
rpoB | 762858 | p.Thr1018Ala | missense_variant | 0.54 | rifampicin | |
rpoB | 762863 | c.3057T>C | synonymous_variant | 0.56 | rifampicin | Not assoc w R - Interim |
rpoB | 762878 | p.Ile1024Met | missense_variant | 0.67 | rifampicin | |
rpoB | 762879 | p.Met1025Leu | missense_variant | 0.69 | rifampicin | Uncertain significance |
rpoB | 762888 | p.His1028Asn | missense_variant | 0.73 | rifampicin | |
rpoC | 762918 | c.-452_-450delCGCinsAGG | upstream_gene_variant | 0.6 | rifampicin | |
rpoB | 762929 | c.3123G>C | synonymous_variant | 0.61 | rifampicin | Not assoc w R - Interim |
rpoB | 762995 | c.3189G>C | synonymous_variant | 0.78 | rifampicin | Not assoc w R - Interim |
rpoB | 763028 | c.3222T>C | synonymous_variant | 0.76 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R |
rpoB | 763031 | c.3225T>G | synonymous_variant | 0.77 | rifampicin | Not assoc w R - Interim |
rpoB | 763040 | c.3234C>G | synonymous_variant | 0.67 | rifampicin | Not assoc w R - Interim |
rpoC | 763052 | c.-318G>C | upstream_gene_variant | 0.61 | rifampicin | |
rpoC | 763065 | c.-305_-304delTCinsAG | upstream_gene_variant | 0.57 | rifampicin | |
rpoB | 763070 | c.3264T>C | synonymous_variant | 0.57 | rifampicin | Not assoc w R - Interim |
rpoB | 763075 | p.Thr1090Ile | missense_variant | 0.54 | rifampicin | |
rpoB | 763085 | c.3279C>G | synonymous_variant | 0.65 | rifampicin | Not assoc w R - Interim |
rpoB | 763094 | c.3288G>C | synonymous_variant | 0.58 | rifampicin | Not assoc w R - Interim |
rpoC | 763103 | c.-267G>C | upstream_gene_variant | 0.58 | rifampicin | |
rpoB | 763104 | p.Ile1100Val | missense_variant | 0.61 | rifampicin | |
rpoC | 763109 | c.-261C>G | upstream_gene_variant | 0.64 | rifampicin | |
rpoB | 763115 | c.3309T>C | synonymous_variant | 0.64 | rifampicin | Not assoc w R - Interim |
rpoB | 763127 | c.3321G>C | synonymous_variant | 0.54 | rifampicin | Not assoc w R - Interim |
rpoB | 763166 | c.3360A>G | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoC | 763169 | c.-201A>G | upstream_gene_variant | 0.5 | rifampicin | |
rpoC | 763480 | c.111C>A | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoC | 763483 | c.114G>C | synonymous_variant | 0.5 | rifampicin | |
rpoC | 763486 | c.117T>G | synonymous_variant | 0.53 | rifampicin | |
rpoC | 763504 | c.135C>G | synonymous_variant | 0.74 | rifampicin | |
rpoC | 763507 | c.138G>C | synonymous_variant | 0.76 | rifampicin | |
rpoC | 763528 | c.159G>C | synonymous_variant | 0.83 | rifampicin | |
rpoC | 763531 | c.162G>C | synonymous_variant | 0.83 | rifampicin | Not assoc w R |
rpoC | 763534 | c.165T>C | synonymous_variant | 0.83 | rifampicin | |
rpoC | 763537 | c.168C>G | synonymous_variant | 0.81 | rifampicin | |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.73 | rifampicin | Not assoc w R - Interim |
rpoC | 763550 | p.Tyr61Ala | missense_variant | 0.75 | rifampicin | |
rpoC | 763594 | c.225C>T | synonymous_variant | 0.78 | rifampicin | Not assoc w R - Interim |
rpoC | 763621 | c.252C>T | synonymous_variant | 0.61 | rifampicin | |
rpoC | 763630 | c.261G>A | synonymous_variant | 0.6 | rifampicin | Not assoc w R - Interim |
rpoC | 763636 | c.267T>C | synonymous_variant | 0.58 | rifampicin | |
rpoC | 763648 | c.279C>T | synonymous_variant | 0.6 | rifampicin | |
rpoC | 763660 | c.291T>G | synonymous_variant | 0.52 | rifampicin | Not assoc w R - Interim |
rpoC | 763666 | c.297G>T | synonymous_variant | 0.57 | rifampicin | |
rpoC | 763669 | c.300C>G | synonymous_variant | 0.57 | rifampicin | Not assoc w R - Interim |
rpoC | 763702 | c.333C>G | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoC | 763703 | c.334_336delTCGinsAGC | synonymous_variant | 0.41 | rifampicin | |
rpoC | 763711 | c.342G>C | synonymous_variant | 0.44 | rifampicin | |
rpoC | 763714 | c.345G>T | synonymous_variant | 0.44 | rifampicin | |
rpoC | 763717 | c.348T>C | synonymous_variant | 0.46 | rifampicin | Not assoc w R - Interim |
rpoC | 763723 | c.354G>C | synonymous_variant | 0.46 | rifampicin | |
rpoC | 763732 | c.363C>G | synonymous_variant | 0.43 | rifampicin | |
rpoC | 763735 | c.366G>C | synonymous_variant | 0.43 | rifampicin | |
rpoC | 763741 | c.372C>T | synonymous_variant | 0.44 | rifampicin | |
rpoC | 763744 | c.375G>C | synonymous_variant | 0.43 | rifampicin | |
rpoC | 763765 | c.396T>C | synonymous_variant | 0.36 | rifampicin | |
rpoC | 763772 | p.Val135Leu | missense_variant | 0.39 | rifampicin | |
rpoC | 764266 | c.897T>G | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoC | 764269 | c.900G>C | synonymous_variant | 0.43 | rifampicin | |
rpoC | 764278 | c.909delAinsGGC | frameshift_variant&synonymous_variant | 0.38 | rifampicin | |
rpoC | 764284 | c.915G>C | synonymous_variant | 0.35 | rifampicin | |
rpoC | 764297 | p.Met310Leu | missense_variant | 0.42 | rifampicin | |
rpoC | 764311 | c.942C>G | synonymous_variant | 0.5 | rifampicin | |
rpoC | 764315 | p.Ala316Cys | missense_variant | 0.52 | rifampicin | |
rpoC | 764339 | p.Leu324Ile | missense_variant | 0.59 | rifampicin | |
rpoC | 764359 | c.990C>G | synonymous_variant | 0.53 | rifampicin | |
rpoC | 764452 | c.1083T>C | synonymous_variant | 0.4 | rifampicin | |
rpoC | 764458 | c.1089G>C | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoC | 764461 | c.1092A>G | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoC | 764497 | c.1128A>G | synonymous_variant | 0.64 | rifampicin | Not assoc w R - Interim |
rpoC | 764498 | p.Ser377Ala | missense_variant | 0.64 | rifampicin | |
rpoC | 764503 | c.1134G>C | synonymous_variant | 0.66 | rifampicin | |
rpoC | 764521 | c.1152T>C | synonymous_variant | 0.65 | rifampicin | Not assoc w R - Interim |
rpoC | 764524 | c.1155C>T | synonymous_variant | 0.66 | rifampicin | |
rpoC | 764536 | c.1167G>C | synonymous_variant | 0.72 | rifampicin | |
rpoC | 764566 | c.1197C>G | synonymous_variant | 0.79 | rifampicin | Not assoc w R - Interim |
rpoC | 764575 | c.1206T>G | synonymous_variant | 0.83 | rifampicin | Not assoc w R - Interim |
rpoC | 764578 | c.1209C>G | synonymous_variant | 0.83 | rifampicin | |
rpoC | 764611 | c.1242G>T | synonymous_variant | 0.93 | rifampicin | Not assoc w R - Interim |
rpoC | 764644 | c.1275G>C | synonymous_variant | 0.8 | rifampicin | Not assoc w R - Interim |
rpoC | 764650 | c.1281G>C | synonymous_variant | 0.72 | rifampicin | |
rpoC | 764656 | c.1287C>G | synonymous_variant | 0.68 | rifampicin | |
rpoC | 764662 | c.1293G>C | synonymous_variant | 0.67 | rifampicin | Not assoc w R - Interim |
rpoC | 764677 | c.1308C>G | synonymous_variant | 0.68 | rifampicin | Not assoc w R - Interim |
rpoC | 764690 | p.Cys441Ala | missense_variant | 0.57 | rifampicin | |
rpoC | 764695 | c.1326T>C | synonymous_variant | 0.58 | rifampicin | |
rpoC | 764701 | c.1332C>G | synonymous_variant | 0.65 | rifampicin | Not assoc w R - Interim |
rpoC | 764746 | c.1377G>A | synonymous_variant | 0.56 | rifampicin | |
rpoC | 764752 | c.1383G>T | synonymous_variant | 0.54 | rifampicin | |
rpoC | 764758 | c.1389C>G | synonymous_variant | 0.54 | rifampicin | Not assoc w R - Interim |
rpoC | 764759 | p.Asn464Gly | missense_variant | 0.53 | rifampicin | |
rpoC | 764764 | c.1395T>C | synonymous_variant | 0.49 | rifampicin | Not assoc w R - Interim |
rpoC | 764767 | c.1398G>C | synonymous_variant | 0.5 | rifampicin | |
rpoC | 764780 | c.1411_1412delAGinsTC | synonymous_variant | 0.61 | rifampicin | |
rpoC | 764791 | c.1422C>G | synonymous_variant | 0.65 | rifampicin | Not assoc w R - Interim |
rpoC | 764812 | c.1443C>G | synonymous_variant | 0.7 | rifampicin | |
rpoC | 764815 | c.1446A>G | synonymous_variant | 0.67 | rifampicin | Not assoc w R - Interim |
rpoC | 764824 | c.1455T>C | synonymous_variant | 0.7 | rifampicin | Not assoc w R - Interim |
rpoC | 764830 | c.1461C>G | synonymous_variant | 0.64 | rifampicin | |
rpoC | 764833 | c.1464A>G | synonymous_variant | 0.61 | rifampicin | |
rpoC | 764844 | p.Ala492Gly | missense_variant | 0.49 | rifampicin | |
rpoC | 764847 | p.Glu493Ala | missense_variant | 0.5 | rifampicin | |
rpoC | 764858 | c.1489T>C | synonymous_variant | 0.51 | rifampicin | Not assoc w R - Interim |
rpoC | 764872 | c.1503A>T | synonymous_variant | 0.62 | rifampicin | |
rpoC | 764893 | c.1524T>C | synonymous_variant | 0.64 | rifampicin | |
rpoC | 764902 | c.1533C>G | synonymous_variant | 0.62 | rifampicin | |
rpoC | 764911 | c.1542A>G | synonymous_variant | 0.55 | rifampicin | |
rpoC | 764912 | p.Met515Gln | missense_variant | 0.55 | rifampicin | Uncertain significance |
rpoC | 764920 | c.1551G>C | synonymous_variant | 0.55 | rifampicin | |
rpoC | 764923 | c.1554A>G | synonymous_variant | 0.55 | rifampicin | Not assoc w R - Interim |
rpoC | 764935 | c.1566T>C | synonymous_variant | 0.57 | rifampicin | |
rpoC | 764939 | c.1570C>T | synonymous_variant | 0.58 | rifampicin | |
rpoC | 764958 | p.Glu530Ala | missense_variant | 0.54 | rifampicin | |
rpoC | 764968 | c.1599T>C | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoC | 765932 | p.Gly855Ser | missense_variant | 0.3 | rifampicin | Uncertain significance |
rpoC | 765937 | c.2568T>G | synonymous_variant | 0.35 | rifampicin | |
rpoC | 765967 | c.2598C>G | synonymous_variant | 0.39 | rifampicin | |
rpoC | 765976 | p.Asp869Glu | missense_variant | 0.38 | rifampicin | Uncertain significance |
rpoC | 765979 | c.2610C>G | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 765982 | c.2613C>T | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoC | 766843 | c.3474T>C | synonymous_variant | 0.57 | rifampicin | Not assoc w R - Interim |
rpoC | 766846 | c.3477C>G | synonymous_variant | 0.57 | rifampicin | Not assoc w R - Interim |
rpoC | 766868 | p.Ile1167Val | missense_variant | 0.35 | rifampicin | |
rpoC | 767002 | c.3633G>C | synonymous_variant | 0.57 | rifampicin | Not assoc w R - Interim |
rpoC | 767023 | p.Asp1218Glu | missense_variant | 0.54 | rifampicin | |
rpoC | 767035 | c.3666G>C | synonymous_variant | 0.57 | rifampicin | Not assoc w R - Interim |
rpoC | 767041 | c.3672G>C | synonymous_variant | 0.54 | rifampicin | |
rpoC | 767044 | c.3675G>C | synonymous_variant | 0.54 | rifampicin | Not assoc w R - Interim |
rpoC | 767059 | c.3690T>C | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 767060 | p.Arg1231Lys | missense_variant | 0.39 | rifampicin | |
rpoC | 767068 | c.3699G>C | synonymous_variant | 0.39 | rifampicin | |
rpoC | 767077 | c.3708G>C | synonymous_variant | 0.43 | rifampicin | |
rpoC | 767087 | p.Cys1240Gly | missense_variant | 0.36 | rifampicin | |
rpoC | 767098 | c.3729T>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
mmpL5 | 777597 | p.Arg295Pro | missense_variant | 1.0 | bedaquiline | |
clofazimine | ||||||
mmpS5 | 779615 | c.-710C>G | upstream_gene_variant | 1.0 | bedaquiline | |
clofazimine | ||||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781772 | c.213C>A | synonymous_variant | 0.47 | streptomycin | |
rpsL | 781793 | c.234G>C | synonymous_variant | 0.52 | streptomycin | |
rpsL | 781796 | p.Met79Ile | missense_variant | 0.55 | streptomycin | |
rpsL | 781805 | c.246G>C | synonymous_variant | 0.54 | streptomycin | |
rpsL | 781817 | c.258G>T | synonymous_variant | 0.63 | streptomycin | |
rpsL | 781832 | c.273T>C | synonymous_variant | 0.67 | streptomycin | |
rpsL | 781835 | c.276T>C | synonymous_variant | 0.71 | streptomycin | Not assoc w R - Interim |
rpsL | 781838 | c.279G>T | synonymous_variant | 0.71 | streptomycin | |
rpsL | 781841 | c.282C>T | synonymous_variant | 0.7 | streptomycin | |
rpsL | 781865 | c.306G>C | synonymous_variant | 0.65 | streptomycin | |
rpsL | 781868 | c.309T>C | synonymous_variant | 0.63 | streptomycin | |
rpsL | 781871 | c.312G>C | synonymous_variant | 0.63 | streptomycin | |
rpsL | 781877 | c.318T>C | synonymous_variant | 0.59 | streptomycin | |
rpsL | 781880 | c.321C>G | synonymous_variant | 0.59 | streptomycin | |
rpsL | 781892 | c.333A>G | synonymous_variant | 0.59 | streptomycin | |
rpsL | 781898 | c.339A>T | synonymous_variant | 0.5 | streptomycin | |
rpsL | 781907 | c.348T>G | synonymous_variant | 0.47 | streptomycin | |
rplC | 800648 | c.-161A>G | upstream_gene_variant | 0.43 | linezolid | |
rplC | 800672 | c.-137G>C | upstream_gene_variant | 0.6 | linezolid | |
rplC | 800693 | c.-116A>G | upstream_gene_variant | 0.53 | linezolid | |
rplC | 800703 | c.-106T>C | upstream_gene_variant | 0.53 | linezolid | |
rplC | 800715 | c.-94A>C | upstream_gene_variant | 0.49 | linezolid | |
rplC | 800720 | c.-89T>C | upstream_gene_variant | 0.45 | linezolid | |
rplC | 800723 | c.-86C>G | upstream_gene_variant | 0.44 | linezolid | |
rplC | 800729 | c.-80G>C | upstream_gene_variant | 0.43 | linezolid | |
rplC | 800735 | c.-74C>G | upstream_gene_variant | 0.44 | linezolid | |
Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471923 | n.78T>C | non_coding_transcript_exon_variant | 0.41 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471925 | n.80T>C | non_coding_transcript_exon_variant | 0.42 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1471932 | n.87A>G | non_coding_transcript_exon_variant | 0.44 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471934 | n.89A>G | non_coding_transcript_exon_variant | 0.45 | kanamycin | |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472075 | n.230A>G | non_coding_transcript_exon_variant | 0.54 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472106 | n.261G>A | non_coding_transcript_exon_variant | 0.71 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472108 | n.263C>T | non_coding_transcript_exon_variant | 0.74 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472122 | n.277G>A | non_coding_transcript_exon_variant | 0.84 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472148 | n.303T>C | non_coding_transcript_exon_variant | 0.9 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472150 | n.305T>A | non_coding_transcript_exon_variant | 0.93 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472172 | n.327T>C | non_coding_transcript_exon_variant | 0.96 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472225 | n.380C>A | non_coding_transcript_exon_variant | 0.79 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472251 | n.406G>A | non_coding_transcript_exon_variant | 0.64 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472382 | n.537G>A | non_coding_transcript_exon_variant | 0.55 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472400 | n.555C>T | non_coding_transcript_exon_variant | 0.6 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472506 | n.661A>T | non_coding_transcript_exon_variant | 0.53 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472530 | n.685G>A | non_coding_transcript_exon_variant | 0.71 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472572 | n.727T>A | non_coding_transcript_exon_variant | 0.88 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472581 | n.736A>C | non_coding_transcript_exon_variant | 0.86 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472583 | n.738T>A | non_coding_transcript_exon_variant | 0.86 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472584 | n.739A>T | non_coding_transcript_exon_variant | 0.86 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472713 | n.868T>C | non_coding_transcript_exon_variant | 0.69 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472714 | n.869A>G | non_coding_transcript_exon_variant | 0.69 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472790 | n.945T>C | non_coding_transcript_exon_variant | 0.7 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472791 | n.946G>T | non_coding_transcript_exon_variant | 0.7 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472952 | n.1107T>C | non_coding_transcript_exon_variant | 0.76 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472957 | n.1112C>T | non_coding_transcript_exon_variant | 0.78 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472973 | n.1128A>T | non_coding_transcript_exon_variant | 0.82 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472987 | n.1142G>A | non_coding_transcript_exon_variant | 0.91 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472989 | n.1144G>A | non_coding_transcript_exon_variant | 0.91 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473035 | n.1190G>A | non_coding_transcript_exon_variant | 0.88 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473055 | n.1210C>T | non_coding_transcript_exon_variant | 0.75 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473056 | n.1211A>T | non_coding_transcript_exon_variant | 0.75 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473065 | n.1220C>A | non_coding_transcript_exon_variant | 0.73 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473066 | n.1221A>G | non_coding_transcript_exon_variant | 0.73 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473097 | n.1252G>A | non_coding_transcript_exon_variant | 0.54 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473100 | n.1255G>A | non_coding_transcript_exon_variant | 0.5 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473104 | n.1259C>T | non_coding_transcript_exon_variant | 0.48 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473105 | n.1260G>A | non_coding_transcript_exon_variant | 0.48 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473110 | n.1265T>G | non_coding_transcript_exon_variant | 0.5 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473111 | n.1266A>G | non_coding_transcript_exon_variant | 0.5 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473121 | n.1276T>C | non_coding_transcript_exon_variant | 0.52 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473122 | n.1277T>A | non_coding_transcript_exon_variant | 0.52 | kanamycin | Uncertain significance |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473145 | n.1300C>T | non_coding_transcript_exon_variant | 0.68 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473158 | n.1313T>C | non_coding_transcript_exon_variant | 0.76 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473166 | n.1321G>A | non_coding_transcript_exon_variant | 0.72 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473252 | n.1407T>C | non_coding_transcript_exon_variant | 0.76 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
streptomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473276 | n.1431A>G | non_coding_transcript_exon_variant | 0.79 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473283 | n.1438T>C | non_coding_transcript_exon_variant | 0.73 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473290 | n.1445C>T | non_coding_transcript_exon_variant | 0.72 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473291 | n.1446_1447insT | non_coding_transcript_exon_variant | 0.76 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473301 | n.1456T>C | non_coding_transcript_exon_variant | 0.77 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473316 | n.1471C>T | non_coding_transcript_exon_variant | 0.79 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1473821 | n.164T>C | non_coding_transcript_exon_variant | 0.5 | capreomycin | |
linezolid | ||||||
rrl | 1473823 | n.166T>C | non_coding_transcript_exon_variant | 0.5 | capreomycin | |
linezolid | ||||||
rrl | 1473833 | n.176_177insT | non_coding_transcript_exon_variant | 0.63 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473844 | n.187C>T | non_coding_transcript_exon_variant | 0.62 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473870 | n.213G>A | non_coding_transcript_exon_variant | 0.59 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473871 | n.214T>C | non_coding_transcript_exon_variant | 0.55 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473876 | n.219G>A | non_coding_transcript_exon_variant | 0.57 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473883 | n.226A>G | non_coding_transcript_exon_variant | 0.47 | capreomycin | |
linezolid | ||||||
rrl | 1473887 | n.230T>A | non_coding_transcript_exon_variant | 0.47 | capreomycin | |
linezolid | ||||||
rrl | 1473888 | n.231T>C | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473890 | n.233T>C | non_coding_transcript_exon_variant | 0.47 | capreomycin | |
linezolid | ||||||
rrl | 1473898 | n.241C>T | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473899 | n.242A>T | non_coding_transcript_exon_variant | 0.42 | capreomycin | |
linezolid | ||||||
rrl | 1473916 | n.259C>A | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474153 | n.496C>G | non_coding_transcript_exon_variant | 0.67 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474166 | n.509G>C | non_coding_transcript_exon_variant | 0.75 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474181 | n.524C>A | non_coding_transcript_exon_variant | 0.69 | capreomycin | |
linezolid | ||||||
rrl | 1474184 | n.527C>T | non_coding_transcript_exon_variant | 0.69 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474186 | n.529A>G | non_coding_transcript_exon_variant | 0.69 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474201 | n.544T>C | non_coding_transcript_exon_variant | 0.71 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474202 | n.545T>A | non_coding_transcript_exon_variant | 0.71 | capreomycin | |
linezolid | ||||||
rrl | 1474218 | n.561T>A | non_coding_transcript_exon_variant | 0.74 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474249 | n.592G>T | non_coding_transcript_exon_variant | 0.68 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474263 | n.606G>A | non_coding_transcript_exon_variant | 0.58 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474269 | n.612C>T | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474359 | n.702C>G | non_coding_transcript_exon_variant | 0.36 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474381 | n.724T>A | non_coding_transcript_exon_variant | 0.43 | capreomycin | |
linezolid | ||||||
rrl | 1474387 | n.730C>T | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474402 | n.745T>C | non_coding_transcript_exon_variant | 0.54 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474466 | n.809G>A | non_coding_transcript_exon_variant | 0.57 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474488 | n.831G>A | non_coding_transcript_exon_variant | 0.62 | capreomycin | |
linezolid | ||||||
rrl | 1474496 | n.839C>A | non_coding_transcript_exon_variant | 0.52 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474497 | n.840G>C | non_coding_transcript_exon_variant | 0.52 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474506 | n.849C>G | non_coding_transcript_exon_variant | 0.48 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474507 | n.850G>T | non_coding_transcript_exon_variant | 0.48 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474516 | n.859C>T | non_coding_transcript_exon_variant | 0.52 | capreomycin | |
linezolid | ||||||
rrl | 1474529 | n.872A>C | non_coding_transcript_exon_variant | 0.48 | capreomycin | |
linezolid | ||||||
rrl | 1474530 | n.873G>A | non_coding_transcript_exon_variant | 0.48 | capreomycin | |
linezolid | ||||||
rrl | 1474537 | n.880G>A | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474539 | n.882C>T | non_coding_transcript_exon_variant | 0.43 | capreomycin | |
linezolid | ||||||
rrl | 1474540 | n.883T>G | non_coding_transcript_exon_variant | 0.46 | capreomycin | |
linezolid | ||||||
rrl | 1474583 | n.926C>T | non_coding_transcript_exon_variant | 0.52 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474779 | n.1122G>A | non_coding_transcript_exon_variant | 0.77 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474784 | n.1127C>T | non_coding_transcript_exon_variant | 0.72 | capreomycin | |
linezolid | ||||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.71 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.76 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474823 | n.1166C>G | non_coding_transcript_exon_variant | 0.75 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474831 | n.1174A>C | non_coding_transcript_exon_variant | 0.77 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474837 | n.1180A>G | non_coding_transcript_exon_variant | 0.83 | capreomycin | |
linezolid | ||||||
rrl | 1474869 | n.1212G>T | non_coding_transcript_exon_variant | 0.8 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474901 | n.1244A>G | non_coding_transcript_exon_variant | 0.68 | capreomycin | |
linezolid | ||||||
rrl | 1474904 | n.1247G>C | non_coding_transcript_exon_variant | 0.68 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474905 | n.1248T>C | non_coding_transcript_exon_variant | 0.64 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474913 | n.1256T>C | non_coding_transcript_exon_variant | 0.65 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475090 | n.1433A>T | non_coding_transcript_exon_variant | 0.69 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475113 | n.1456C>T | non_coding_transcript_exon_variant | 0.75 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475114 | n.1457C>T | non_coding_transcript_exon_variant | 0.75 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475116 | n.1459G>A | non_coding_transcript_exon_variant | 0.71 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475499 | n.1842C>T | non_coding_transcript_exon_variant | 0.67 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.68 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475536 | n.1879C>T | non_coding_transcript_exon_variant | 0.61 | capreomycin | |
linezolid | ||||||
rrl | 1475538 | n.1881T>A | non_coding_transcript_exon_variant | 0.64 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475539 | n.1882A>T | non_coding_transcript_exon_variant | 0.64 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475544 | n.1887A>C | non_coding_transcript_exon_variant | 0.64 | capreomycin | |
linezolid | ||||||
rrl | 1475545 | n.1888T>G | non_coding_transcript_exon_variant | 0.64 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475573 | n.1916G>A | non_coding_transcript_exon_variant | 0.62 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475649 | n.1992A>G | non_coding_transcript_exon_variant | 0.55 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475655 | n.1998T>C | non_coding_transcript_exon_variant | 0.58 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475659 | n.2002G>A | non_coding_transcript_exon_variant | 0.71 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475688 | n.2031G>A | non_coding_transcript_exon_variant | 0.8 | capreomycin | |
linezolid | ||||||
rrl | 1475692 | n.2035G>T | non_coding_transcript_exon_variant | 0.79 | capreomycin | |
linezolid | ||||||
rrl | 1475707 | n.2050T>C | non_coding_transcript_exon_variant | 0.62 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475713 | n.2056C>T | non_coding_transcript_exon_variant | 0.65 | capreomycin | |
linezolid | ||||||
rrl | 1475753 | n.2096C>G | non_coding_transcript_exon_variant | 0.46 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475775 | n.2118G>T | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475883 | n.2226A>G | non_coding_transcript_exon_variant | 0.84 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475900 | n.2243A>G | non_coding_transcript_exon_variant | 0.8 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475952 | n.2295A>G | non_coding_transcript_exon_variant | 0.72 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475970 | n.2313C>T | non_coding_transcript_exon_variant | 0.71 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475975 | n.2318C>T | non_coding_transcript_exon_variant | 0.7 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475977 | n.2320A>G | non_coding_transcript_exon_variant | 0.67 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475988 | n.2331A>G | non_coding_transcript_exon_variant | 0.64 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1475997 | n.2340A>T | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476000 | n.2343G>A | non_coding_transcript_exon_variant | 0.53 | capreomycin | |
linezolid | ||||||
rrl | 1476001 | n.2344T>C | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476164 | n.2507A>G | non_coding_transcript_exon_variant | 0.72 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476165 | n.2508T>A | non_coding_transcript_exon_variant | 0.75 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476179 | n.2522C>T | non_coding_transcript_exon_variant | 0.69 | capreomycin | |
linezolid | ||||||
rrl | 1476194 | n.2537A>G | non_coding_transcript_exon_variant | 0.6 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476200 | n.2543A>T | non_coding_transcript_exon_variant | 0.61 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476201 | n.2544C>T | non_coding_transcript_exon_variant | 0.64 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476213 | n.2556G>T | non_coding_transcript_exon_variant | 0.62 | capreomycin | |
linezolid | ||||||
rrl | 1476214 | n.2557G>T | non_coding_transcript_exon_variant | 0.57 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.57 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476229 | n.2572C>A | non_coding_transcript_exon_variant | 0.57 | capreomycin | |
linezolid | ||||||
rrl | 1476279 | n.2622G>A | non_coding_transcript_exon_variant | 0.62 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 0.62 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476297 | n.2640C>A | non_coding_transcript_exon_variant | 0.74 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476300 | n.2643G>T | non_coding_transcript_exon_variant | 0.78 | capreomycin | |
linezolid | ||||||
rrl | 1476301 | n.2644A>T | non_coding_transcript_exon_variant | 0.78 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476359 | n.2702C>G | non_coding_transcript_exon_variant | 0.84 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476381 | n.2724G>C | non_coding_transcript_exon_variant | 0.86 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476423 | n.2766T>C | non_coding_transcript_exon_variant | 0.9 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476428 | n.2771C>T | non_coding_transcript_exon_variant | 0.89 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476506 | n.2849T>C | non_coding_transcript_exon_variant | 0.77 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476523 | n.2866T>C | non_coding_transcript_exon_variant | 0.6 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476524 | n.2867C>A | non_coding_transcript_exon_variant | 0.6 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476525 | n.2868A>G | non_coding_transcript_exon_variant | 0.6 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476528 | n.2871A>G | non_coding_transcript_exon_variant | 0.6 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476529 | n.2872A>T | non_coding_transcript_exon_variant | 0.6 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476536 | n.2879G>A | non_coding_transcript_exon_variant | 0.6 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476539 | n.2882A>G | non_coding_transcript_exon_variant | 0.6 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476540 | n.2883C>G | non_coding_transcript_exon_variant | 0.6 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476584 | n.2927C>T | non_coding_transcript_exon_variant | 0.68 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476585 | n.2928A>G | non_coding_transcript_exon_variant | 0.68 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476594 | n.2937C>T | non_coding_transcript_exon_variant | 0.56 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.54 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476603 | n.2946G>A | non_coding_transcript_exon_variant | 0.54 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476608 | n.2951C>G | non_coding_transcript_exon_variant | 0.54 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476614 | n.2957A>T | non_coding_transcript_exon_variant | 0.52 | capreomycin | |
linezolid | ||||||
rrl | 1476619 | n.2962C>T | non_coding_transcript_exon_variant | 0.52 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.5 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476629 | n.2972C>A | non_coding_transcript_exon_variant | 0.5 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476630 | n.2973A>G | non_coding_transcript_exon_variant | 0.5 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rpsA | 1833646 | c.105T>C | synonymous_variant | 0.61 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1833666 | p.Thr42Ser | missense_variant | 0.7 | pyrazinamide | |
rpsA | 1833676 | c.135A>G | synonymous_variant | 0.68 | pyrazinamide | |
rpsA | 1833677 | p.Val46Ile | missense_variant | 0.68 | pyrazinamide | |
rpsA | 1833685 | c.144G>C | synonymous_variant | 0.72 | pyrazinamide | |
rpsA | 1833697 | c.156C>G | synonymous_variant | 0.66 | pyrazinamide | |
rpsA | 1833709 | c.168C>T | synonymous_variant | 0.57 | pyrazinamide | |
rpsA | 1833727 | c.186G>C | synonymous_variant | 0.59 | pyrazinamide | |
rpsA | 1833734 | p.Ala65Ser | missense_variant | 0.55 | pyrazinamide | |
rpsA | 1833949 | c.408T>C | synonymous_variant | 0.53 | pyrazinamide | |
rpsA | 1833970 | c.429G>T | synonymous_variant | 0.6 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.55 | pyrazinamide | |
rpsA | 1833991 | c.450C>G | synonymous_variant | 0.62 | pyrazinamide | |
rpsA | 1834000 | c.459G>C | synonymous_variant | 0.65 | pyrazinamide | |
rpsA | 1834012 | c.471G>T | synonymous_variant | 0.63 | pyrazinamide | |
rpsA | 1834015 | c.474G>C | synonymous_variant | 0.66 | pyrazinamide | |
rpsA | 1834030 | c.489C>G | synonymous_variant | 0.56 | pyrazinamide | |
rpsA | 1834034 | p.Ile165Val | missense_variant | 0.52 | pyrazinamide | |
rpsA | 1834040 | p.Lys167Arg | missense_variant | 0.5 | pyrazinamide | |
rpsA | 1834043 | p.Glu168Gln | missense_variant | 0.48 | pyrazinamide | |
rpsA | 1834046 | p.Ile169Leu | missense_variant | 0.48 | pyrazinamide | |
rpsA | 1834051 | p.Glu170Asp | missense_variant | 0.56 | pyrazinamide | |
rpsA | 1834069 | c.528G>C | synonymous_variant | 0.67 | pyrazinamide | |
rpsA | 1834177 | c.636A>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834213 | c.672G>C | synonymous_variant | 0.48 | pyrazinamide | |
rpsA | 1834231 | c.690T>G | synonymous_variant | 0.52 | pyrazinamide | |
rpsA | 1834240 | c.699T>C | synonymous_variant | 0.6 | pyrazinamide | |
rpsA | 1834249 | c.708T>C | synonymous_variant | 0.62 | pyrazinamide | |
rpsA | 1834261 | c.720A>G | synonymous_variant | 0.68 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834264 | c.723G>C | synonymous_variant | 0.7 | pyrazinamide | |
rpsA | 1834298 | p.Gln253Glu | missense_variant | 0.75 | pyrazinamide | |
rpsA | 1834303 | c.762T>C | synonymous_variant | 0.67 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 0.62 | pyrazinamide | |
rpsA | 1834307 | p.Asp256Gln | missense_variant | 0.62 | pyrazinamide | |
rpsA | 1834312 | c.771G>A | synonymous_variant | 0.66 | pyrazinamide | |
rpsA | 1834330 | c.789C>T | synonymous_variant | 0.62 | pyrazinamide | |
rpsA | 1834333 | c.792C>T | synonymous_variant | 0.63 | pyrazinamide | |
rpsA | 1834348 | c.807T>C | synonymous_variant | 0.66 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834357 | c.816T>C | synonymous_variant | 0.64 | pyrazinamide | |
rpsA | 1834361 | c.820T>C | synonymous_variant | 0.66 | pyrazinamide | |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.6 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834375 | c.834G>C | synonymous_variant | 0.62 | pyrazinamide | |
rpsA | 1834378 | c.837T>C | synonymous_variant | 0.59 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834387 | c.846C>T | synonymous_variant | 0.67 | pyrazinamide | |
rpsA | 1834390 | c.849G>C | synonymous_variant | 0.68 | pyrazinamide | |
rpsA | 1834411 | c.870T>C | synonymous_variant | 0.71 | pyrazinamide | |
rpsA | 1834423 | c.882G>C | synonymous_variant | 0.73 | pyrazinamide | |
rpsA | 1834438 | c.897C>T | synonymous_variant | 0.63 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834439 | p.Lys300Arg | missense_variant | 0.63 | pyrazinamide | |
rpsA | 1834451 | c.910T>C | synonymous_variant | 0.67 | pyrazinamide | |
rpsA | 1834456 | c.915T>G | synonymous_variant | 0.7 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 0.6 | pyrazinamide | |
rpsA | 1834477 | c.936C>G | synonymous_variant | 0.47 | pyrazinamide | |
rpsA | 1834480 | c.939C>G | synonymous_variant | 0.47 | pyrazinamide | |
rpsA | 1834481 | p.Glu314Tyr | missense_variant | 0.47 | pyrazinamide | |
rpsA | 1834486 | p.Glu315Asp | missense_variant | 0.5 | pyrazinamide | |
rpsA | 1834489 | c.948T>C | synonymous_variant | 0.5 | pyrazinamide | |
rpsA | 1834498 | c.957C>T | synonymous_variant | 0.47 | pyrazinamide | |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
kasA | 2517917 | c.-198G>A | upstream_gene_variant | 0.3 | isoniazid | |
kasA | 2517921 | c.-194A>G | upstream_gene_variant | 0.3 | isoniazid | |
Rv2477c | 2782903 | c.1140C>G | synonymous_variant | 0.47 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782913 | p.Ser377Asn | missense_variant | 0.64 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782927 | p.Thr372Gln | missense_variant | 0.63 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782936 | c.1107G>C | synonymous_variant | 0.7 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782957 | c.1086A>G | synonymous_variant | 0.7 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2782969 | c.1074A>C | synonymous_variant | 0.66 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782972 | c.1071G>C | synonymous_variant | 0.65 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782981 | c.1062G>C | synonymous_variant | 0.62 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782984 | c.1059T>C | synonymous_variant | 0.58 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782990 | c.1053C>T | synonymous_variant | 0.58 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783143 | p.Lys300Arg | missense_variant | 0.45 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783149 | c.894G>C | synonymous_variant | 0.5 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | ||||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783157 | p.Ala296Thr | missense_variant | 0.5 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783158 | c.885A>C | synonymous_variant | 0.5 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
fbiD | 3339564 | c.447G>A | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
Rv3236c | 3612813 | p.Thr102Ala | missense_variant | 0.9 | pyrazinamide | Not assoc w R - Interim |
mtrB | 3625065 | p.Met517Leu | missense_variant | 0.91 | rifampicin | Not assoc w R |
bedaquiline | Uncertain significance | |||||
rpoA | 3877623 | c.885C>T | synonymous_variant | 0.35 | rifampicin | |
rpoA | 3877629 | c.879C>G | synonymous_variant | 0.34 | rifampicin | |
rpoA | 3877656 | c.852T>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoA | 3878053 | p.Asn152Ser | missense_variant | 1.0 | rifampicin | |
clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.46 | pyrazinamide | |
clpC1 | 4038779 | c.1926C>G | synonymous_variant | 0.44 | pyrazinamide | |
clpC1 | 4038794 | p.Ser637Thr | missense_variant | 0.56 | pyrazinamide | |
clpC1 | 4038810 | p.Gln632Pro | missense_variant | 0.55 | pyrazinamide | |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.57 | pyrazinamide | |
clpC1 | 4038860 | c.1845G>C | synonymous_variant | 0.77 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038868 | p.Lys613Gln | missense_variant | 0.15 | pyrazinamide | |
clpC1 | 4038869 | c.1836G>A | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.48 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038881 | c.1824C>G | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4038905 | c.1800A>G | synonymous_variant | 0.43 | pyrazinamide | |
clpC1 | 4039018 | p.Ser563Thr | missense_variant | 0.45 | pyrazinamide | |
clpC1 | 4039022 | c.1683A>G | synonymous_variant | 0.45 | pyrazinamide | |
clpC1 | 4039028 | c.1677G>A | synonymous_variant | 0.46 | pyrazinamide | |
clpC1 | 4039046 | c.1659C>G | synonymous_variant | 0.45 | pyrazinamide | |
clpC1 | 4039067 | c.1638G>C | synonymous_variant | 0.52 | pyrazinamide | |
clpC1 | 4039070 | c.1635G>C | synonymous_variant | 0.44 | pyrazinamide | |
clpC1 | 4039073 | c.1632C>A | synonymous_variant | 0.48 | pyrazinamide | |
clpC1 | 4039079 | c.1626C>G | synonymous_variant | 0.46 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039082 | c.1623C>T | synonymous_variant | 0.46 | pyrazinamide | |
clpC1 | 4039085 | c.1620A>G | synonymous_variant | 0.43 | pyrazinamide | |
clpC1 | 4039090 | c.1615C>T | synonymous_variant | 0.41 | pyrazinamide | |
clpC1 | 4039091 | c.1614G>C | synonymous_variant | 0.42 | pyrazinamide | |
clpC1 | 4039106 | c.1599G>C | synonymous_variant | 0.39 | pyrazinamide | |
clpC1 | 4039217 | c.1488G>C | synonymous_variant | 0.29 | pyrazinamide | |
clpC1 | 4039226 | c.1479T>C | synonymous_variant | 0.32 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039229 | c.1476C>G | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039239 | p.Gly489Ala | missense_variant | 0.32 | pyrazinamide | |
clpC1 | 4039622 | c.1083C>G | synonymous_variant | 0.4 | pyrazinamide | |
clpC1 | 4039646 | p.Glu353Ala | missense_variant | 0.32 | pyrazinamide | |
clpC1 | 4039682 | c.1023C>T | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4039685 | c.1020C>G | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4039694 | c.1011G>C | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039697 | p.Ala336Pro | missense_variant | 0.56 | pyrazinamide | |
clpC1 | 4039711 | p.Ile332Val | missense_variant | 0.37 | pyrazinamide | |
clpC1 | 4039724 | c.981A>G | synonymous_variant | 0.62 | pyrazinamide | |
clpC1 | 4039733 | c.972G>C | synonymous_variant | 0.56 | pyrazinamide | |
clpC1 | 4039742 | c.963C>T | synonymous_variant | 0.42 | pyrazinamide | |
clpC1 | 4039748 | c.957G>C | synonymous_variant | 0.52 | pyrazinamide | |
clpC1 | 4039751 | c.954A>G | synonymous_variant | 0.43 | pyrazinamide | |
clpC1 | 4039757 | c.948A>G | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4039760 | c.945T>C | synonymous_variant | 0.4 | pyrazinamide | |
clpC1 | 4039766 | c.939T>C | synonymous_variant | 0.54 | pyrazinamide | |
clpC1 | 4039769 | c.936C>G | synonymous_variant | 0.42 | pyrazinamide | |
clpC1 | 4039773 | p.Lys311Met | missense_variant | 0.52 | pyrazinamide | |
clpC1 | 4039778 | c.927A>G | synonymous_variant | 0.46 | pyrazinamide | |
clpC1 | 4039787 | c.916_918delTCGinsAGC | synonymous_variant | 0.48 | pyrazinamide | |
clpC1 | 4039817 | c.888A>C | synonymous_variant | 0.66 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039820 | c.885T>C | synonymous_variant | 0.66 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039829 | c.874_876delTTGinsCTC | synonymous_variant | 0.69 | pyrazinamide | |
clpC1 | 4039838 | p.Leu289Ile | missense_variant | 0.62 | pyrazinamide | |
clpC1 | 4039850 | c.855T>C | synonymous_variant | 0.68 | pyrazinamide | |
clpC1 | 4039855 | p.Leu284Met | missense_variant | 0.67 | pyrazinamide | |
clpC1 | 4039865 | c.840T>C | synonymous_variant | 0.69 | pyrazinamide | |
clpC1 | 4039875 | p.Asn277Arg | missense_variant | 0.65 | pyrazinamide | |
clpC1 | 4039898 | c.807C>G | synonymous_variant | 0.64 | pyrazinamide | |
clpC1 | 4039901 | c.804C>G | synonymous_variant | 0.59 | pyrazinamide | |
clpC1 | 4039904 | c.801A>G | synonymous_variant | 0.57 | pyrazinamide | |
clpC1 | 4039907 | c.798G>A | synonymous_variant | 0.55 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039916 | c.789T>C | synonymous_variant | 0.52 | pyrazinamide | |
clpC1 | 4039929 | c.775_776delAGinsTC | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039934 | c.771G>C | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4040015 | c.690G>C | synonymous_variant | 0.53 | pyrazinamide | |
clpC1 | 4040024 | c.681A>G | synonymous_variant | 0.61 | pyrazinamide | |
clpC1 | 4040033 | c.672G>C | synonymous_variant | 0.65 | pyrazinamide | |
clpC1 | 4040084 | c.621C>G | synonymous_variant | 0.62 | pyrazinamide | |
clpC1 | 4040087 | c.618G>T | synonymous_variant | 0.55 | pyrazinamide | |
clpC1 | 4040090 | c.615T>C | synonymous_variant | 0.5 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040093 | c.612C>G | synonymous_variant | 0.5 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040315 | p.Glu130Asp | missense_variant | 0.62 | pyrazinamide | |
clpC1 | 4040324 | c.381G>C | synonymous_variant | 0.73 | pyrazinamide | |
clpC1 | 4040348 | c.357G>C | synonymous_variant | 0.64 | pyrazinamide | |
clpC1 | 4040351 | c.354C>T | synonymous_variant | 0.6 | pyrazinamide | |
clpC1 | 4040357 | c.348T>C | synonymous_variant | 0.6 | pyrazinamide | |
clpC1 | 4040363 | c.342A>C | synonymous_variant | 0.55 | pyrazinamide | |
clpC1 | 4040375 | c.330G>C | synonymous_variant | 0.52 | pyrazinamide | |
clpC1 | 4040380 | c.325T>C | synonymous_variant | 0.48 | pyrazinamide | |
clpC1 | 4040387 | c.318A>G | synonymous_variant | 0.46 | pyrazinamide | |
clpC1 | 4040393 | c.312G>C | synonymous_variant | 0.43 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040618 | c.87C>T | synonymous_variant | 0.3 | pyrazinamide | |
clpC1 | 4040644 | c.61A>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4040654 | c.51G>A | synonymous_variant | 0.37 | pyrazinamide | |
clpC1 | 4040657 | c.48T>C | synonymous_variant | 0.37 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040669 | c.36C>T | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4040674 | c.31A>C | synonymous_variant | 0.41 | pyrazinamide | |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embA | 4243460 | c.228C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |
gid | 4407927 | p.Glu92Asp | missense_variant | 1.0 | streptomycin | Not assoc w R |