TB-Profiler result

Run: SRR28351554
Summary

Run ID: SRR28351554

Sample name:

Date: 2024-05-22T17:42:44.740190

Number of reads: 1155374

Percentage reads mapped: 84.2

Median coverage: 20.0

Strain: La1.6;lineage4

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
La1.7.1 M.bovis None 0.14
La1.6 M.bovis None 0.06
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fgd1 c.730_732delAACinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.838_840delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC c.601_603delATGinsCC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.799_801delCTAinsTG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.820_822delTTAinsAG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.859_861delATCinsGT Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fgd1 491512 c.730_732delAACinsGG frameshift_variant&missense_variant 0.91 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fgd1 491620 c.838_840delATCinsGG frameshift_variant&missense_variant 0.91 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303531 c.601_603delATGinsCC frameshift_variant&missense_variant 0.66 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303729 c.799_801delCTAinsTG frameshift_variant&stop_gained 0.52 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303750 c.820_822delTTAinsAG frameshift_variant&missense_variant 0.42 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGT frameshift_variant&missense_variant 0.38 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 822 c.822A>G synonymous_variant 0.89 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.89 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.87 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.87 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.91 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.92 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.92 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.92 isoniazid Not assoc w R - Interim
dnaA 877 c.877T>C synonymous_variant 0.89 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.89 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.9 isoniazid
dnaA 909 c.909A>G synonymous_variant 0.88 isoniazid
dnaA 912 c.912T>G synonymous_variant 0.88 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.88 isoniazid Not assoc w R - Interim
dnaA 933 c.933C>G synonymous_variant 0.86 isoniazid
dnaA 936 c.936C>G synonymous_variant 0.86 isoniazid
dnaA 939 c.939C>G synonymous_variant 0.85 isoniazid
dnaA 951 c.951G>C synonymous_variant 0.84 isoniazid
dnaA 955 c.955_957delAGAinsCT frameshift_variant&missense_variant 0.82 isoniazid Uncertain significance
dnaA 966 c.966T>C synonymous_variant 0.8 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.84 isoniazid Not assoc w R - Interim
dnaA 990 c.990A>C synonymous_variant 0.82 isoniazid
gyrB 6130 c.891T>C synonymous_variant 0.71 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.75 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6139 c.900G>C synonymous_variant 0.82 levofloxacin
moxifloxacin
gyrB 6148 c.909C>G synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrB 6160 c.921C>G synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrB 6184 c.945C>G synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrB 6196 c.957C>T synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrB 6202 c.963C>G synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrB 6204 p.Ser322Thr missense_variant 0.94 levofloxacin
moxifloxacin
gyrB 6209 c.970C>T synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrB 6215 c.976_978delTCGinsAGC synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.95 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>C synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrB 6253 c.1014G>C synonymous_variant 0.95 levofloxacin
moxifloxacin
gyrB 6262 c.1023G>A synonymous_variant 0.94 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.93 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 6307 c.-995T>C upstream_gene_variant 0.92 levofloxacin
moxifloxacin
gyrB 6326 p.Ser363Ala missense_variant 0.8 levofloxacin
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrB 6346 c.1107C>T synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6352 c.1113C>G synonymous_variant 0.78 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6358 c.1119C>G synonymous_variant 0.82 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6362 c.1123_1125delTTGinsCC frameshift_variant&missense_variant 0.8 levofloxacin Uncertain significance
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 6460 c.-842G>C upstream_gene_variant 0.65 levofloxacin
moxifloxacin
gyrA 6466 c.-836G>A upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrA 6472 c.-830G>T upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6475 c.-827C>G upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6484 c.-818A>G upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6496 c.-806G>C upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6499 c.-803A>G upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6502 c.-800T>C upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6526 c.-776T>C upstream_gene_variant 0.85 levofloxacin
moxifloxacin
gyrA 6535 c.-767C>A upstream_gene_variant 0.88 levofloxacin
moxifloxacin
gyrA 6547 c.-755T>C upstream_gene_variant 0.89 levofloxacin
moxifloxacin
gyrA 6550 c.-752A>C upstream_gene_variant 0.89 levofloxacin
moxifloxacin
gyrB 6551 c.1312T>C synonymous_variant 0.89 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6565 c.-737G>C upstream_gene_variant 0.91 levofloxacin
moxifloxacin
gyrA 6571 c.-731T>C upstream_gene_variant 0.91 levofloxacin
moxifloxacin
gyrB 6577 c.1338T>C synonymous_variant 0.91 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6580 c.-722C>G upstream_gene_variant 0.91 levofloxacin
moxifloxacin
gyrB 6590 p.Arg451Ser missense_variant 0.92 levofloxacin
moxifloxacin
gyrA 6610 c.-692C>G upstream_gene_variant 0.88 levofloxacin
moxifloxacin
gyrA 6613 c.-689A>G upstream_gene_variant 0.86 levofloxacin
moxifloxacin
gyrA 6616 c.-686A>G upstream_gene_variant 0.85 levofloxacin
moxifloxacin
gyrA 6619 c.-683T>C upstream_gene_variant 0.85 levofloxacin
moxifloxacin
gyrA 6622 c.-680C>T upstream_gene_variant 0.87 levofloxacin
moxifloxacin
gyrA 6628 c.-674C>A upstream_gene_variant 0.85 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.87 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.87 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>C upstream_gene_variant 0.86 levofloxacin
moxifloxacin
gyrA 6643 c.-659A>G upstream_gene_variant 0.85 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.86 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.86 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.84 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.83 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.79 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.77 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.76 levofloxacin
moxifloxacin
gyrA 6724 c.-578G>C upstream_gene_variant 0.73 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.72 levofloxacin Uncertain significance
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6749 c.1510_1512delGCGinsTC frameshift_variant&missense_variant 0.74 levofloxacin Uncertain significance
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.74 levofloxacin
moxifloxacin
gyrA 6775 c.-527G>T upstream_gene_variant 0.75 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Asp missense_variant 0.75 levofloxacin
moxifloxacin
gyrA 6823 c.-479G>C upstream_gene_variant 0.64 levofloxacin
moxifloxacin
gyrA 6838 c.-464C>G upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 7442 c.141G>T synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 7445 c.144C>G synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.76 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.86 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 7529 c.228G>C synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.87 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.87 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.77 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.8 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9200 c.1899A>G synonymous_variant 0.58 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9212 c.1911G>C synonymous_variant 0.62 levofloxacin
moxifloxacin
gyrA 9213 p.Thr638Val missense_variant 0.63 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.75 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.83 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.87 levofloxacin
moxifloxacin
gyrA 9257 c.1956C>T synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 9263 c.1962C>G synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9267 p.Asn656Gly missense_variant 0.86 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.91 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.89 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 0.94 levofloxacin
moxifloxacin
gyrA 9311 c.2010C>T synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.9 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9332 p.Asn677Lys missense_variant 0.9 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.89 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>T synonymous_variant 0.88 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>A synonymous_variant 0.85 levofloxacin
moxifloxacin
gyrA 9392 c.2091C>G synonymous_variant 0.78 levofloxacin
moxifloxacin
gyrA 9395 c.2094G>C synonymous_variant 0.74 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.73 levofloxacin
moxifloxacin
fgd1 491453 p.Gly224Asp missense_variant 0.73 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fgd1 491461 p.Lys227Arg missense_variant 0.79 clofazimine
pretomanid
delamanid
fgd1 491472 c.690A>G synonymous_variant 0.88 clofazimine
pretomanid
delamanid
fgd1 491493 c.711C>G synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fgd1 491496 c.714C>T synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491499 c.717G>C synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491503 p.Leu241Lys missense_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491509 c.727T>C synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491520 c.738C>G synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fgd1 491526 c.744T>C synonymous_variant 0.96 clofazimine
pretomanid
delamanid
fgd1 491542 c.760T>C synonymous_variant 0.95 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>G synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.93 clofazimine
pretomanid
delamanid
fgd1 491604 c.822G>A synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>C synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fgd1 491640 c.858G>C synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>C synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.9 clofazimine
pretomanid
delamanid
fgd1 491667 c.885A>G synonymous_variant 0.88 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>C synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fgd1 491676 c.894T>C synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 491679 c.897A>G synonymous_variant 0.83 clofazimine
pretomanid
delamanid
fgd1 491685 c.903G>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fgd1 491688 c.906A>G synonymous_variant 0.81 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491697 c.915G>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fgd1 491709 c.927A>G synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fgd1 491712 c.930T>C synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fgd1 491721 c.939A>C synonymous_variant 0.66 clofazimine
pretomanid
delamanid
mshA 575761 c.414C>T synonymous_variant 0.33 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575771 p.Val142Thr missense_variant 0.37 ethionamide
isoniazid
mshA 575776 c.429C>T synonymous_variant 0.4 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.4 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.4 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.4 ethionamide
isoniazid
mshA 575800 c.453G>C synonymous_variant 0.45 ethionamide
isoniazid
ccsA 620664 c.774C>T synonymous_variant 0.59 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>G synonymous_variant 0.71 capreomycin
amikacin
kanamycin
ccsA 620698 p.Val270Ile missense_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620712 c.822G>C synonymous_variant 0.73 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.72 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.7 capreomycin
amikacin
kanamycin
ccsA 620724 c.834C>T synonymous_variant 0.7 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620736 c.846G>C synonymous_variant 0.68 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.68 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.68 capreomycin
amikacin
kanamycin
ccsA 620745 c.855G>A synonymous_variant 0.68 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>C synonymous_variant 0.68 capreomycin
amikacin
kanamycin
ccsA 620754 c.864G>T synonymous_variant 0.7 capreomycin
amikacin
kanamycin
ccsA 620757 c.867C>T synonymous_variant 0.7 capreomycin
amikacin
kanamycin
ccsA 620760 c.870C>T synonymous_variant 0.72 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.73 capreomycin
amikacin
kanamycin
ccsA 620783 p.Ala298Val missense_variant 0.71 capreomycin
amikacin
kanamycin
ccsA 620793 c.903G>C synonymous_variant 0.69 capreomycin
amikacin
kanamycin
ccsA 620796 c.906C>G synonymous_variant 0.68 capreomycin
amikacin
kanamycin
Rv0565c 657081 c.390G>A synonymous_variant 0.38 ethionamide Not assoc w R - Interim
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.61 rifampicin
nusG 734415 c.162C>T synonymous_variant 0.76 rifampicin
nusG 734421 c.168A>C synonymous_variant 0.78 rifampicin
nusG 734424 c.171G>T synonymous_variant 0.77 rifampicin
nusG 734439 c.186C>G synonymous_variant 0.85 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.86 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.85 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.84 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.84 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.85 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.86 rifampicin
nusG 734508 c.255C>G synonymous_variant 0.87 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.87 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.85 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.83 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.88 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760683 c.877_879delTTGinsCC frameshift_variant&missense_variant 0.89 rifampicin
rpoB 760715 c.909C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760727 c.921C>T synonymous_variant 0.78 rifampicin
rpoB 760730 c.924T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.75 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.71 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.74 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.74 rifampicin
rpoB 760764 p.Glu320Gln missense_variant 0.72 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.7 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.65 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.67 rifampicin
rpoC 763789 c.420C>T synonymous_variant 0.72 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.73 rifampicin
rpoC 763801 c.432C>T synonymous_variant 0.76 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.8 rifampicin
rpoC 763816 c.447C>G synonymous_variant 0.79 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.82 rifampicin
rpoC 763837 c.468G>C synonymous_variant 0.85 rifampicin
rpoC 763840 c.471G>C synonymous_variant 0.86 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.87 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.87 rifampicin
rpoC 763867 c.498C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 763871 p.Gly168Ser missense_variant 0.87 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.87 rifampicin
rpoC 763877 c.508_510delCTAinsTG frameshift_variant&stop_gained 0.86 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.85 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.85 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.85 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.87 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.8 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.74 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.73 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 766672 c.3303T>C synonymous_variant 0.48 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.72 rifampicin
rpoC 766694 c.3325_3327delCAGinsGC frameshift_variant&missense_variant 0.73 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.84 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.83 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.82 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.85 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.85 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.84 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.84 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.84 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
mmpL5 775844 c.2637G>C synonymous_variant 0.38 clofazimine
bedaquiline
mmpL5 775851 p.Ser877Thr missense_variant 0.39 clofazimine
bedaquiline
mmpL5 775853 c.2628C>G synonymous_variant 0.39 clofazimine
bedaquiline
mmpL5 775856 c.2625T>C synonymous_variant 0.54 clofazimine
bedaquiline
mmpL5 775865 c.2616T>C synonymous_variant 0.58 clofazimine
bedaquiline
mmpL5 775885 p.Ile866Leu missense_variant 0.54 clofazimine
bedaquiline
mmpL5 775886 c.2595A>C synonymous_variant 0.65 clofazimine
bedaquiline
mmpL5 775892 c.2589C>T synonymous_variant 0.44 clofazimine
bedaquiline
mmpL5 775895 c.2586C>A synonymous_variant 0.56 clofazimine
bedaquiline
mmpL5 775901 c.2580G>A synonymous_variant 0.41 clofazimine
bedaquiline
mmpL5 775904 c.2577G>A synonymous_variant 0.52 clofazimine
bedaquiline
mmpL5 775909 p.Leu858Phe missense_variant 0.42 clofazimine
bedaquiline
mmpL5 775915 p.Ala856Ser missense_variant 0.54 clofazimine
bedaquiline
mmpL5 775916 c.2565T>A synonymous_variant 0.61 clofazimine
bedaquiline
mmpL5 775922 c.2559G>A synonymous_variant 0.54 clofazimine
bedaquiline
mmpL5 775937 c.2544G>C synonymous_variant 0.61 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.63 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.5 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.59 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 0.4 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781608 p.Ser17Ala missense_variant 0.86 streptomycin
rpsL 781616 c.57C>G synonymous_variant 0.87 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.9 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.92 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.96 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.96 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.96 streptomycin
rpsL 781682 c.123T>G synonymous_variant 0.97 streptomycin
rpsL 781703 c.144G>A synonymous_variant 0.97 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.98 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.97 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.97 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.97 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.97 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.97 streptomycin
rpsL 781742 c.183C>G synonymous_variant 0.97 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.97 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.97 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.97 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.97 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.97 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.97 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.94 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.94 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.93 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.92 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.92 streptomycin
rpsL 781853 c.294C>T synonymous_variant 0.89 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.89 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.89 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.9 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.9 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.91 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.93 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.93 streptomycin
rpsL 781910 c.351C>T synonymous_variant 0.93 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.95 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.95 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.95 streptomycin
rplC 800516 c.-293G>C upstream_gene_variant 0.55 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.68 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.67 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.68 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.68 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.66 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.64 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.63 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.64 linezolid
rplC 800603 c.-206G>T upstream_gene_variant 0.66 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.79 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.83 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.77 linezolid
rplC 800639 c.-170C>T upstream_gene_variant 0.76 linezolid
rplC 800645 c.-164C>G upstream_gene_variant 0.75 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.78 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.74 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.73 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.72 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.71 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.71 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.69 linezolid
rplC 800729 c.-80G>C upstream_gene_variant 0.66 linezolid
rplC 800744 c.-65G>T upstream_gene_variant 0.65 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.54 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.5 linezolid
rplC 800844 c.36T>C synonymous_variant 0.78 linezolid
rplC 800856 c.48A>G synonymous_variant 0.83 linezolid
rplC 800865 c.57A>G synonymous_variant 0.82 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.83 linezolid
rplC 800873 p.Arg22Lys missense_variant 0.83 linezolid
rplC 800877 c.69A>C synonymous_variant 0.86 linezolid
rplC 800880 c.72A>C synonymous_variant 0.86 linezolid
rplC 800889 c.81C>G synonymous_variant 0.88 linezolid
rplC 800892 c.84G>C synonymous_variant 0.88 linezolid
rplC 800895 c.87C>G synonymous_variant 0.9 linezolid
rplC 800904 c.96G>C synonymous_variant 0.9 linezolid
rplC 800916 c.108A>G synonymous_variant 0.87 linezolid
rplC 800922 c.114C>T synonymous_variant 0.88 linezolid
rplC 800928 c.120C>T synonymous_variant 0.9 linezolid
rplC 800931 c.123G>C synonymous_variant 0.9 linezolid
rplC 800932 p.Pro42Thr missense_variant 0.88 linezolid
rplC 800937 c.129A>G synonymous_variant 0.88 linezolid
rplC 800946 c.138T>C synonymous_variant 0.87 linezolid
rplC 800949 c.141T>C synonymous_variant 0.87 linezolid
rplC 800964 c.156G>C synonymous_variant 0.84 linezolid
rplC 800985 c.177A>G synonymous_variant 0.77 linezolid
fbiC 1303492 c.562T>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1303500 c.570C>T synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303503 c.573G>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303506 c.576C>T synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>G synonymous_variant 0.51 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1303548 c.618G>C synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1303551 c.621G>C synonymous_variant 0.76 clofazimine
pretomanid
delamanid
fbiC 1303554 c.624G>C synonymous_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.82 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.84 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fbiC 1303620 c.690C>T synonymous_variant 0.87 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303632 c.702T>G synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.86 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.79 clofazimine
pretomanid
delamanid
fbiC 1303660 p.Val244Thr missense_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1303665 c.735G>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1303666 p.Thr246Asp missense_variant 0.78 clofazimine
pretomanid
delamanid
fbiC 1303689 c.759T>C synonymous_variant 0.77 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.8 clofazimine
pretomanid
delamanid
fbiC 1303713 c.783C>G synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1303716 c.786C>T synonymous_variant 0.68 clofazimine
pretomanid
delamanid
fbiC 1303722 c.792C>T synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Thr missense_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.52 clofazimine
pretomanid
delamanid
fbiC 1303740 c.810C>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1303746 p.Asp272Glu missense_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303764 c.834C>G synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1303788 c.858T>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303794 c.864A>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.42 clofazimine
pretomanid
delamanid
fbiC 1303827 p.Glu299Asp missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.87 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.89 clofazimine
pretomanid
delamanid
fbiC 1304709 c.1779C>G synonymous_variant 0.91 clofazimine
pretomanid
delamanid
fbiC 1304718 c.1788C>G synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.94 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.92 clofazimine
pretomanid
delamanid
fbiC 1304751 c.1821C>G synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fbiC 1304769 c.1839C>G synonymous_variant 0.95 clofazimine
pretomanid
delamanid
fbiC 1304772 c.1842C>T synonymous_variant 0.95 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304784 c.1854T>G synonymous_variant 0.94 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.95 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.95 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.97 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.95 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.95 clofazimine
pretomanid
delamanid
fbiC 1304823 c.1893C>T synonymous_variant 0.96 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.95 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.95 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.87 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrl 1474439 n.782A>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475395 n.1738T>G non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475398 n.1741C>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475404 n.1747A>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475430 n.1773T>G non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
inhA 1673493 c.-709C>G upstream_gene_variant 0.32 ethionamide
isoniazid
inhA 1673499 c.-703T>C upstream_gene_variant 0.52 ethionamide
isoniazid Uncertain significance
inhA 1673505 c.-697A>T upstream_gene_variant 0.62 ethionamide
isoniazid
inhA 1673517 c.-685G>T upstream_gene_variant 0.64 ethionamide
isoniazid
inhA 1673523 c.-679G>C upstream_gene_variant 0.66 ethionamide
isoniazid
inhA 1673535 c.-667A>G upstream_gene_variant 0.73 ethionamide
isoniazid
inhA 1673547 c.-655T>C upstream_gene_variant 0.77 ethionamide
isoniazid
inhA 1673571 c.-631C>G upstream_gene_variant 0.76 ethionamide
isoniazid
inhA 1673574 c.-628C>G upstream_gene_variant 0.77 ethionamide
isoniazid
inhA 1673580 c.-622T>C upstream_gene_variant 0.8 ethionamide
isoniazid Uncertain significance
inhA 1673589 c.-613A>G upstream_gene_variant 0.82 ethionamide
isoniazid
inhA 1673595 c.-607A>C upstream_gene_variant 0.83 ethionamide
isoniazid
fabG1 1673596 p.Lys53Glu missense_variant 0.83 ethionamide
isoniazid
inhA 1673602 c.-600C>T upstream_gene_variant 0.86 ethionamide
isoniazid
inhA 1673607 c.-595T>C upstream_gene_variant 0.88 ethionamide
isoniazid
fabG1 1673615 p.Glu59Val missense_variant 0.87 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.86 ethionamide
isoniazid
fabG1 1673637 p.Asp66Glu missense_variant 0.86 ethionamide
isoniazid
inhA 1673646 c.-556T>C upstream_gene_variant 0.83 ethionamide
isoniazid
inhA 1673652 c.-550C>G upstream_gene_variant 0.79 ethionamide
isoniazid
fabG1 1673657 p.Thr73Lys missense_variant 0.76 ethionamide
isoniazid
fabG1 1673660 p.Ala74Glu missense_variant 0.76 ethionamide
isoniazid
inhA 1673664 c.-538A>C upstream_gene_variant 0.76 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.87 ethionamide
isoniazid
inhA 1674514 p.Ile105Val missense_variant 0.88 ethionamide
isoniazid
inhA 1674540 c.339C>T synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.91 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.91 ethionamide
isoniazid
inhA 1674576 c.375T>C synonymous_variant 0.93 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.93 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.94 ethionamide
isoniazid
inhA 1674600 c.399G>C synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674601 p.Leu134Val missense_variant 0.94 ethionamide
isoniazid
inhA 1674621 c.420C>G synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.94 ethionamide
isoniazid
inhA 1674628 p.Ser143Gly missense_variant 0.94 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.9 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.89 ethionamide
isoniazid
inhA 1674669 c.468G>T synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674702 c.501G>C synonymous_variant 0.87 ethionamide
isoniazid
inhA 1674703 c.502_504delTTGinsCC frameshift_variant&missense_variant 0.87 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.85 ethionamide
isoniazid
inhA 1674729 c.528G>A synonymous_variant 0.86 ethionamide
isoniazid
inhA 1674732 c.531C>T synonymous_variant 0.85 ethionamide
isoniazid
inhA 1674738 c.537C>G synonymous_variant 0.84 ethionamide
isoniazid
inhA 1674745 p.Tyr182Val missense_variant 0.84 ethionamide
isoniazid
inhA 1674750 c.549T>C synonymous_variant 0.84 ethionamide
isoniazid
inhA 1674753 c.552G>C synonymous_variant 0.85 ethionamide
isoniazid
inhA 1674756 c.555T>G synonymous_variant 0.86 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674774 c.573A>C synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674777 c.576C>G synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.9 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674810 c.609C>G synonymous_variant 0.93 ethionamide
isoniazid
inhA 1674825 c.624C>T synonymous_variant 0.92 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674828 p.Glu209Asp missense_variant 0.91 ethionamide
isoniazid
inhA 1674837 c.636C>G synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674840 c.639C>G synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.92 ethionamide
isoniazid
inhA 1674876 c.675C>T synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.91 ethionamide
isoniazid
inhA 1674883 p.Ile228Leu missense_variant 0.91 ethionamide
isoniazid
inhA 1674888 c.687C>A synonymous_variant 0.92 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.89 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.89 ethionamide
isoniazid
inhA 1674909 c.708G>T synonymous_variant 0.88 ethionamide
isoniazid
inhA 1674924 c.723G>C synonymous_variant 0.86 ethionamide
isoniazid
inhA 1674933 c.732G>C synonymous_variant 0.82 ethionamide
isoniazid
inhA 1674942 c.741T>C synonymous_variant 0.78 ethionamide
isoniazid
inhA 1674954 c.753G>C synonymous_variant 0.56 ethionamide
isoniazid
rpsA 1833970 c.429G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1834468 c.927A>G synonymous_variant 0.33 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.37 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.5 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.77 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.77 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.77 linezolid
tsnR 1853387 c.-219T>C upstream_gene_variant 0.77 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.77 linezolid
tsnR 1853394 c.-212_-210delCTCinsGCG upstream_gene_variant 0.77 linezolid
tsnR 1853417 c.-189G>C upstream_gene_variant 0.74 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.7 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.53 linezolid
tlyA 1917972 c.33A>G synonymous_variant 0.92 capreomycin Not assoc w R
kasA 2517917 c.-198G>T upstream_gene_variant 0.98 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.98 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.96 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.95 isoniazid
kasA 2517968 c.-147T>G upstream_gene_variant 0.94 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.93 isoniazid
kasA 2517980 c.-135C>G upstream_gene_variant 0.9 isoniazid
kasA 2517983 c.-132T>C upstream_gene_variant 0.87 isoniazid
kasA 2517989 c.-126T>G upstream_gene_variant 0.82 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.5 isoniazid
kasA 2518135 c.21T>C synonymous_variant 0.53 isoniazid
kasA 2518138 c.24T>C synonymous_variant 0.53 isoniazid
kasA 2518146 p.Phe11Tyr missense_variant 0.5 isoniazid
kasA 2518152 p.Ser13Asn missense_variant 0.53 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.48 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.5 isoniazid
kasA 2518183 c.69G>C synonymous_variant 0.5 isoniazid
kasA 2518184 p.Ser24Ala missense_variant 0.5 isoniazid
kasA 2518187 p.Ile25Leu missense_variant 0.5 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.5 isoniazid
kasA 2518223 c.109T>C synonymous_variant 0.45 isoniazid
kasA 2518228 c.114C>A synonymous_variant 0.45 isoniazid
kasA 2518240 c.126C>T synonymous_variant 0.43 isoniazid
kasA 2518245 p.His44Arg missense_variant 0.43 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.43 isoniazid
kasA 2518255 c.141A>G synonymous_variant 0.4 isoniazid
kasA 2518564 c.450C>T synonymous_variant 0.79 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.79 isoniazid
kasA 2518573 c.459G>T synonymous_variant 0.79 isoniazid
kasA 2518574 p.Ile154Ala missense_variant 0.79 isoniazid
kasA 2518579 c.465T>G synonymous_variant 0.81 isoniazid
kasA 2518582 c.468G>T synonymous_variant 0.82 isoniazid
kasA 2518583 p.Gln157Glu missense_variant 0.82 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.82 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.82 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.83 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.81 isoniazid
kasA 2518612 c.498C>G synonymous_variant 0.81 isoniazid
kasA 2518627 c.513T>C synonymous_variant 0.82 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.82 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.85 isoniazid
kasA 2518645 c.531G>C synonymous_variant 0.84 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.79 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.78 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.7 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.69 isoniazid
kasA 2518688 p.Val192Phe missense_variant 0.5 isoniazid
kasA 2518699 c.585C>T synonymous_variant 0.44 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.44 isoniazid
kasA 2518708 c.594C>A synonymous_variant 0.44 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.44 isoniazid
kasA 2518715 p.Pro201Gly missense_variant 0.44 isoniazid
kasA 2518723 c.609G>A synonymous_variant 0.44 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.44 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.39 isoniazid
kasA 2519257 c.1143C>T synonymous_variant 0.41 isoniazid
folC 2746728 c.871T>C synonymous_variant 0.61 para-aminosalicylic_acid
folC 2746730 p.Tyr290Phe missense_variant 0.65 para-aminosalicylic_acid
folC 2746744 c.855T>G synonymous_variant 0.74 para-aminosalicylic_acid
folC 2746747 c.852G>A synonymous_variant 0.74 para-aminosalicylic_acid
folC 2746767 p.Gln278Glu missense_variant 0.77 para-aminosalicylic_acid
folC 2746773 p.Val276Leu missense_variant 0.79 para-aminosalicylic_acid
folC 2746785 p.Val272Ile missense_variant 0.77 para-aminosalicylic_acid
folC 2746786 c.813G>C synonymous_variant 0.77 para-aminosalicylic_acid
folC 2746789 c.808_810delATCinsGG frameshift_variant&missense_variant 0.74 para-aminosalicylic_acid
folC 2746795 c.804A>C synonymous_variant 0.74 para-aminosalicylic_acid
folC 2746798 c.799_801delCGGinsGA frameshift_variant&synonymous_variant 0.73 para-aminosalicylic_acid
folC 2746801 c.798A>G synonymous_variant 0.72 para-aminosalicylic_acid
folC 2746804 c.795G>T synonymous_variant 0.72 para-aminosalicylic_acid
folC 2746827 c.772C>A synonymous_variant 0.77 para-aminosalicylic_acid
folC 2746831 c.768G>C synonymous_variant 0.77 para-aminosalicylic_acid
folC 2746836 p.Ser255Ala missense_variant 0.77 para-aminosalicylic_acid
folC 2746837 c.762G>C synonymous_variant 0.77 para-aminosalicylic_acid
folC 2746849 c.750G>C synonymous_variant 0.73 para-aminosalicylic_acid
Rv2477c 2782501 c.1542T>C synonymous_variant 0.77 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782528 c.1515G>C synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>C synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782546 c.1497C>G synonymous_variant 0.86 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.86 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.86 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782564 c.1479G>C synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782586 p.Leu486Glu missense_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782591 c.1452T>G synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782594 c.1449T>C synonymous_variant 0.81 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782606 p.Gly479Ser missense_variant 0.78 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782611 c.1432C>T synonymous_variant 0.77 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782612 c.1431T>G synonymous_variant 0.76 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782621 c.1422T>C synonymous_variant 0.75 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782624 c.1419G>C synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782633 c.1410G>C synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782639 c.1404A>G synonymous_variant 0.75 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782651 c.1392T>C synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782657 c.1386C>T synonymous_variant 0.62 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyX 3067619 c.327A>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067625 c.321C>G synonymous_variant 0.62 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.73 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.78 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.79 para-aminosalicylic_acid
thyX 3067669 c.277C>T synonymous_variant 0.79 para-aminosalicylic_acid
thyX 3067680 p.Cys89Ala missense_variant 0.79 para-aminosalicylic_acid
thyX 3067682 c.264G>T synonymous_variant 0.79 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.79 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.78 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.8 para-aminosalicylic_acid
thyX 3067697 c.249C>G synonymous_variant 0.79 para-aminosalicylic_acid
thyX 3067715 c.229_231delAGCinsTCG synonymous_variant 0.79 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.79 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.78 para-aminosalicylic_acid
thyX 3067727 c.219A>T synonymous_variant 0.8 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.79 para-aminosalicylic_acid
thyX 3067742 c.204A>G synonymous_variant 0.79 para-aminosalicylic_acid
thyX 3067748 c.198C>T synonymous_variant 0.8 para-aminosalicylic_acid
thyX 3067760 c.186G>C synonymous_variant 0.76 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.77 para-aminosalicylic_acid
thyX 3067773 p.Ala58Asp missense_variant 0.69 para-aminosalicylic_acid
thyX 3067775 c.171C>T synonymous_variant 0.67 para-aminosalicylic_acid
lpqB 3624614 c.297A>G synonymous_variant 0.48 bedaquiline
rifampicin
lpqB 3624636 p.His92Arg missense_variant 0.71 bedaquiline
rifampicin Uncertain significance
lpqB 3624659 c.252C>G synonymous_variant 0.76 bedaquiline
rifampicin
lpqB 3624671 c.238_240delGCCinsAG frameshift_variant&missense_variant 0.77 bedaquiline
rifampicin Uncertain significance
lpqB 3624675 p.Asn79Ser missense_variant 0.77 bedaquiline
rifampicin
lpqB 3624677 c.234C>G synonymous_variant 0.79 bedaquiline
rifampicin
lpqB 3624680 c.231T>C synonymous_variant 0.76 bedaquiline
rifampicin
lpqB 3624695 c.216C>T synonymous_variant 0.73 bedaquiline
rifampicin
lpqB 3624701 c.210T>C synonymous_variant 0.73 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.76 bedaquiline
rifampicin
lpqB 3624713 c.198C>T synonymous_variant 0.72 bedaquiline
rifampicin
lpqB 3624725 c.186G>C synonymous_variant 0.75 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.73 bedaquiline
rifampicin
lpqB 3624734 c.177A>C synonymous_variant 0.68 bedaquiline
rifampicin
lpqB 3624740 c.171G>A synonymous_variant 0.69 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624749 c.162G>A synonymous_variant 0.7 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.69 bedaquiline
rifampicin Uncertain significance
lpqB 3624770 c.141T>C synonymous_variant 0.48 bedaquiline
rifampicin
mtrB 3625177 c.1437C>T synonymous_variant 0.71 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625183 c.-273G>T upstream_gene_variant 0.72 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.75 bedaquiline
rifampicin
lpqB 3625195 c.-285A>G upstream_gene_variant 0.73 bedaquiline
rifampicin
lpqB 3625198 c.-288C>G upstream_gene_variant 0.73 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.76 bedaquiline
rifampicin
lpqB 3625204 c.-294G>C upstream_gene_variant 0.75 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.84 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625237 c.-327G>A upstream_gene_variant 0.91 bedaquiline
rifampicin
lpqB 3625240 c.-330T>C upstream_gene_variant 0.9 bedaquiline
rifampicin
lpqB 3625243 c.-333T>C upstream_gene_variant 0.9 bedaquiline
rifampicin
lpqB 3625246 c.-336G>C upstream_gene_variant 0.91 bedaquiline
rifampicin
lpqB 3625251 c.-341C>T upstream_gene_variant 0.93 bedaquiline
rifampicin
lpqB 3625258 c.-348G>C upstream_gene_variant 0.95 bedaquiline
rifampicin
mtrB 3625262 p.Tyr451Phe missense_variant 0.95 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.95 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.93 bedaquiline
rifampicin
lpqB 3625279 c.-369C>G upstream_gene_variant 0.95 bedaquiline
rifampicin
lpqB 3625285 c.-375G>C upstream_gene_variant 0.95 bedaquiline
rifampicin
lpqB 3625291 c.-381A>G upstream_gene_variant 0.95 bedaquiline
rifampicin
mtrB 3625325 p.His430Arg missense_variant 0.88 bedaquiline
rifampicin
lpqB 3625327 c.-417A>G upstream_gene_variant 0.88 bedaquiline
rifampicin
lpqB 3625333 c.-423C>T upstream_gene_variant 0.88 bedaquiline
rifampicin
mtrB 3625342 c.1272C>G synonymous_variant 0.87 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625345 c.-435T>C upstream_gene_variant 0.85 bedaquiline
rifampicin
mtrB 3625351 c.1263T>C synonymous_variant 0.85 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625354 c.-444G>C upstream_gene_variant 0.83 bedaquiline
rifampicin
lpqB 3625366 c.-456C>T upstream_gene_variant 0.78 bedaquiline
rifampicin
lpqB 3625375 c.-465A>G upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.53 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.57 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625744 c.870G>A synonymous_variant 0.68 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625753 p.Ala287Gln missense_variant 0.76 bedaquiline
rifampicin
lpqB 3625762 c.-852A>C upstream_gene_variant 0.74 bedaquiline
rifampicin
lpqB 3625765 c.-855C>A upstream_gene_variant 0.74 bedaquiline
rifampicin
mtrB 3625774 c.840G>A synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625801 c.-891G>T upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3625804 c.808_810delAGGinsCC frameshift_variant&missense_variant 0.61 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625807 c.807C>G synonymous_variant 0.61 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625819 c.795G>A synonymous_variant 0.63 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625822 c.-912C>T upstream_gene_variant 0.63 bedaquiline
rifampicin
lpqB 3625828 c.-918G>C upstream_gene_variant 0.63 bedaquiline
rifampicin
mtrB 3625845 p.Ser257Thr missense_variant 0.65 bedaquiline
rifampicin
mtrA 3626749 c.601C>T synonymous_variant 0.6 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626750 c.-137T>G upstream_gene_variant 0.61 bedaquiline
rifampicin
mtrB 3626773 c.-160C>T upstream_gene_variant 0.8 bedaquiline
rifampicin
mtrA 3626774 c.574_576delAGGinsCT frameshift_variant&missense_variant 0.79 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.81 bedaquiline
rifampicin
mtrB 3626786 c.-173A>C upstream_gene_variant 0.79 bedaquiline
rifampicin
mtrB 3626792 c.-179G>C upstream_gene_variant 0.79 bedaquiline
rifampicin
mtrB 3626795 c.-182C>T upstream_gene_variant 0.79 bedaquiline
rifampicin
mtrB 3626798 c.-185T>A upstream_gene_variant 0.8 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.79 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.75 bedaquiline
rifampicin
mtrB 3626843 c.-230G>C upstream_gene_variant 0.76 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.74 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.75 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.76 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.76 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.77 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.78 bedaquiline
rifampicin
mtrB 3626879 c.-266G>C upstream_gene_variant 0.79 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.71 bedaquiline
rifampicin
mtrB 3626894 c.-281C>T upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrA 3626906 c.442_444delAACinsCG frameshift_variant&missense_variant 0.35 bedaquiline
rifampicin
fbiB 3642668 c.1134A>C synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiB 3642674 c.1140C>G synonymous_variant 0.81 clofazimine
pretomanid
delamanid
fbiB 3642683 c.1149C>G synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fbiB 3642684 c.1150T>C synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fbiB 3642695 c.1161G>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiB 3642701 c.1167C>G synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiB 3642707 c.1173C>G synonymous_variant 0.74 clofazimine
pretomanid
delamanid
fbiB 3642709 p.Gly392Asp missense_variant 0.74 clofazimine
pretomanid
delamanid
fbiB 3642711 p.Leu393Val missense_variant 0.74 clofazimine
pretomanid
delamanid
fbiB 3642719 c.1185T>C synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiB 3642740 c.1206C>A synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiB 3642743 c.1209T>C synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiB 3642748 p.Ala405Gly missense_variant 0.7 clofazimine
pretomanid
delamanid
fbiB 3642752 c.1218C>T synonymous_variant 0.72 clofazimine
pretomanid
delamanid
fbiB 3642761 c.1227C>T synonymous_variant 0.7 clofazimine
pretomanid
delamanid
fbiB 3642763 p.Asp410Ala missense_variant 0.7 clofazimine
pretomanid
delamanid
fbiB 3642768 c.1234C>T synonymous_variant 0.67 clofazimine
pretomanid
delamanid
fbiB 3642779 c.1245A>C synonymous_variant 0.62 clofazimine
pretomanid
delamanid
fbiB 3642781 p.Val416Asp missense_variant 0.6 clofazimine
pretomanid
delamanid
rpoA 3878055 c.453A>G synonymous_variant 0.5 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.68 rifampicin
rpoA 3878064 c.444G>C synonymous_variant 0.75 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.83 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.87 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.9 rifampicin
rpoA 3878106 c.402G>T synonymous_variant 0.91 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.93 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.94 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.96 rifampicin Uncertain significance
rpoA 3878157 c.351C>G synonymous_variant 0.96 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.96 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.98 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3878256 c.252G>C synonymous_variant 0.96 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.96 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.92 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3878761 c.-254G>C upstream_gene_variant 0.55 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.57 rifampicin
rpoA 3878774 c.-268_-267delAGinsTC upstream_gene_variant 0.59 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.64 rifampicin
rpoA 3878791 c.-284C>T upstream_gene_variant 0.63 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.65 rifampicin
rpoA 3878802 c.-295G>C upstream_gene_variant 0.65 rifampicin
rpoA 3878811 c.-304A>G upstream_gene_variant 0.64 rifampicin
rpoA 3878814 c.-307C>G upstream_gene_variant 0.65 rifampicin
rpoA 3878823 c.-316G>C upstream_gene_variant 0.64 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.64 rifampicin
rpoA 3878830 c.-323G>C upstream_gene_variant 0.68 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.7 rifampicin
rpoA 3878843 c.-337_-336delCGinsAA upstream_gene_variant 0.7 rifampicin
rpoA 3878845 c.-340_-338delGTGinsAC upstream_gene_variant 0.7 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.67 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.53 rifampicin Uncertain significance
rpoA 3878886 c.-379G>A upstream_gene_variant 0.46 rifampicin Uncertain significance
clpC1 4038255 p.Val817Lys missense_variant 0.61 pyrazinamide
clpC1 4038272 c.2433T>C synonymous_variant 0.81 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.8 pyrazinamide
clpC1 4038288 p.Asn806Gly missense_variant 0.8 pyrazinamide
clpC1 4038290 p.Asp805Glu missense_variant 0.79 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.82 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.83 pyrazinamide
clpC1 4038305 c.2400C>G synonymous_variant 0.84 pyrazinamide
clpC1 4038310 p.Val799Leu missense_variant 0.85 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.85 pyrazinamide
clpC1 4038320 c.2385G>A synonymous_variant 0.88 pyrazinamide
clpC1 4038350 c.2355C>G synonymous_variant 0.9 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.91 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.93 pyrazinamide
clpC1 4038380 c.2325C>G synonymous_variant 0.94 pyrazinamide
clpC1 4038383 c.2322G>C synonymous_variant 0.94 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.94 pyrazinamide
clpC1 4038392 c.2313C>G synonymous_variant 0.94 pyrazinamide
clpC1 4038398 c.2307G>C synonymous_variant 0.94 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.94 pyrazinamide Not assoc w R - Interim
clpC1 4038410 c.2295C>T synonymous_variant 0.95 pyrazinamide
clpC1 4038416 c.2289C>G synonymous_variant 0.96 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.95 pyrazinamide
clpC1 4038440 c.2265C>G synonymous_variant 0.95 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.95 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.95 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.95 pyrazinamide
clpC1 4038461 c.2244G>C synonymous_variant 0.95 pyrazinamide
clpC1 4038474 p.Ser744Thr missense_variant 0.95 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.94 pyrazinamide
clpC1 4038488 p.Ala739Gly missense_variant 0.94 pyrazinamide
clpC1 4038499 p.Ser736Gly missense_variant 0.95 pyrazinamide
clpC1 4038519 p.Arg729Lys missense_variant 0.94 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.94 pyrazinamide
clpC1 4038533 p.Arg724Gln missense_variant 0.94 pyrazinamide
clpC1 4038536 c.2169C>G synonymous_variant 0.94 pyrazinamide
clpC1 4038569 c.2136C>T synonymous_variant 0.92 pyrazinamide
clpC1 4038575 c.2130C>G synonymous_variant 0.91 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.91 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.72 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.77 pyrazinamide Not assoc w R - Interim
clpC1 4039265 c.1440C>T synonymous_variant 0.87 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>C synonymous_variant 0.9 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.9 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.9 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.88 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.88 pyrazinamide
clpC1 4039313 c.1392C>G synonymous_variant 0.85 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.84 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.85 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.8 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.91 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.98 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.98 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.97 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.98 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.98 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.99 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.98 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.98 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.98 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.98 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.98 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.98 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.98 pyrazinamide Not assoc w R - Interim
clpC1 4040066 c.639G>C synonymous_variant 0.97 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.95 pyrazinamide
clpC1 4040090 c.615T>G synonymous_variant 0.95 pyrazinamide
clpC1 4040126 c.579C>T synonymous_variant 0.93 pyrazinamide Not assoc w R - Interim
clpC1 4040141 c.564C>T synonymous_variant 0.94 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.92 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4040159 c.546G>T synonymous_variant 0.88 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
clpC1 4040168 c.537G>C synonymous_variant 0.85 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.84 pyrazinamide
clpC1 4040192 c.513C>G synonymous_variant 0.68 pyrazinamide
clpC1 4040219 c.486C>G synonymous_variant 0.5 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.73 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.82 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.88 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.88 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.88 pyrazinamide
clpC1 4040252 c.453C>T synonymous_variant 0.89 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.89 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.429C>G synonymous_variant 0.88 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.87 pyrazinamide
clpC1 4040300 c.405C>T synonymous_variant 0.88 pyrazinamide
clpC1 4040306 c.399G>C synonymous_variant 0.89 pyrazinamide
clpC1 4040336 c.369G>T synonymous_variant 0.89 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.88 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.89 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.9 pyrazinamide
clpC1 4040360 c.345G>A synonymous_variant 0.92 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.92 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.93 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.93 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.93 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.93 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.94 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.95 pyrazinamide Not assoc w R - Interim
clpC1 4040419 c.286C>T synonymous_variant 0.95 pyrazinamide
clpC1 4040423 c.282A>G synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.96 pyrazinamide
clpC1 4040435 c.270G>C synonymous_variant 0.96 pyrazinamide
clpC1 4040441 c.264C>T synonymous_variant 0.96 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.96 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4040465 c.240T>C synonymous_variant 0.96 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.96 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.96 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.96 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.94 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.93 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.88 pyrazinamide
clpC1 4040549 c.154_156delTTGinsCC frameshift_variant&missense_variant 0.89 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.84 pyrazinamide
clpC1 4040570 c.135C>G synonymous_variant 0.59 pyrazinamide
panD 4044114 c.168C>G synonymous_variant 0.52 pyrazinamide
panD 4044120 c.162A>G synonymous_variant 0.53 pyrazinamide
panD 4044123 c.159T>C synonymous_variant 0.54 pyrazinamide
panD 4044126 c.156T>C synonymous_variant 0.56 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
panD 4044147 c.135C>G synonymous_variant 0.63 pyrazinamide
panD 4044150 c.132A>G synonymous_variant 0.62 pyrazinamide
panD 4044156 c.126A>G synonymous_variant 0.63 pyrazinamide Not assoc w R - Interim
panD 4044159 c.123C>T synonymous_variant 0.63 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.59 pyrazinamide
panD 4044171 c.111C>T synonymous_variant 0.58 pyrazinamide
panD 4044180 p.Asp34Glu missense_variant 0.57 pyrazinamide
panD 4044186 c.94_96delTTGinsCC frameshift_variant&missense_variant 0.55 pyrazinamide Uncertain significance
panD 4044195 c.87T>C synonymous_variant 0.53 pyrazinamide
panD 4044240 c.42G>C synonymous_variant 0.45 pyrazinamide
glpK 4138424 c.1332T>C synonymous_variant 0.61 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138427 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.59 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138442 c.1314C>T synonymous_variant 0.79 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138457 p.Asp433Ser missense_variant 0.81 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138464 p.Gly431Ala missense_variant 0.79 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138466 c.1290C>G synonymous_variant 0.82 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138478 c.1278T>C synonymous_variant 0.88 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138481 c.1275G>C synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138490 c.1266G>T synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138495 p.Gln421Glu missense_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138496 c.1260G>T synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138500 p.Arg419His missense_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138502 c.1254T>G synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138511 c.1245C>T synonymous_variant 0.88 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138514 c.1242A>C synonymous_variant 0.88 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138529 c.1227G>C synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138532 c.1224G>C synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138535 c.1221T>C synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138544 c.1212G>A synonymous_variant 0.89 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138568 c.1188A>G synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138574 c.1182G>C synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138596 p.Phe387Tyr missense_variant 0.91 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138606 c.1150T>C synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.88 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.88 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.9 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138655 c.1101G>C synonymous_variant 0.89 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138661 c.1095T>C synonymous_variant 0.9 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138667 c.1089G>C synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138676 c.1080T>C synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138681 p.Met359Val missense_variant 0.86 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138682 c.1074C>G synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138696 p.Pro354Ser missense_variant 0.87 ethambutol Uncertain significance
moxifloxacin
streptomycin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138703 c.1053C>T synonymous_variant 0.87 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138712 c.1044G>A synonymous_variant 0.84 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.81 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embA 4245128 c.1896G>A synonymous_variant 1.0 ethambutol
ethR 4327559 p.Ser4Phe missense_variant 1.0 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
gid 4407836 p.Trp123Arg missense_variant 0.75 streptomycin