TB-Profiler result

Run: ERR9119733
Summary

Run ID: ERR9119733

Sample name:

Date: 2024-10-03T22:22:32.616722

Number of reads: 2651480

Percentage reads mapped: 57.38

Median coverage: 60.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
p.Ile21Val Uncertain significance Mutation from literature
katG p.Ser140Asn Uncertain significance Mutation from literature
ethambutol embA c.-12C>T Uncertain significance Mutation from literature
pyrazinamide
streptomycin rrs n.799C>T Uncertain significance Mutation from literature
gid c.102delG Assoc w R
c.87delC Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
ethR p.Ala95Thr Uncertain significance Mutation from literature
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 0.99 rifampicin Assoc w R
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.66 amikacin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.62 amikacin Assoc w R
capreomycin Assoc w R
kanamycin Assoc w R
inhA 1673425 c.-777C>T upstream_gene_variant 1.0 ethionamide Assoc w R Alias fabG1_c.-15C>T
isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
inhA 1674262 p.Ile21Val missense_variant 0.59 isoniazid Uncertain significance Mutation from literature
katG 2155693 p.Ser140Asn missense_variant 0.16 isoniazid Uncertain significance Mutation from literature
embA 4243221 c.-12C>T upstream_gene_variant 0.96 ethambutol Uncertain significance Mutation from literature
ethR 4327831 p.Ala95Thr missense_variant 1.0 ethionamide Uncertain significance Mutation from literature
gid 4408100 c.102delG frameshift_variant 0.39 streptomycin Assoc w R
gid 4408115 c.87delC frameshift_variant 0.62 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7419 p.Ala40Thr missense_variant 0.29 levofloxacin Uncertain significance
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 0.98 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575907 p.Ala187Val missense_variant 1.0 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
rpoB 761006 c.1200C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761064 p.Ala420Ser missense_variant 0.24 rifampicin Uncertain significance
rpoB 761088 c.1282_1283delAGinsTC synonymous_variant 0.19 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.16 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.15 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762002 c.2196C>G synonymous_variant 0.14 rifampicin
rpoB 762003 p.Asn733Gln missense_variant 0.14 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762015 p.Glu737Gln missense_variant 0.13 rifampicin
rpoB 762020 p.Glu738Asp missense_variant 0.14 rifampicin
rpoB 762026 c.2220G>C synonymous_variant 0.16 rifampicin
rpoB 762030 p.Thr742Ser missense_variant 0.16 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762057 p.Ile751Val missense_variant 0.14 rifampicin Uncertain significance
rpoB 762062 c.2256T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.13 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762156 p.Val784Ile missense_variant 0.16 rifampicin
rpoB 762162 p.Ile786Val missense_variant 0.19 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762189 p.Ile795Leu missense_variant 0.23 rifampicin
rpoB 762194 c.2388G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762212 c.2406G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.28 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.22 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.21 rifampicin Uncertain significance
rpoC 762896 c.-474G>C upstream_gene_variant 0.27 rifampicin
rpoB 762899 c.3093G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762917 c.-453C>T upstream_gene_variant 0.32 rifampicin
rpoB 762923 c.3117C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762926 c.-444C>G upstream_gene_variant 0.32 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 762971 c.-399G>C upstream_gene_variant 0.22 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.12 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763040 c.3234C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763043 c.-327G>C upstream_gene_variant 0.15 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.14 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.14 rifampicin
rpoB 763077 p.Val1091Pro missense_variant 0.14 rifampicin
rpoC 763082 c.-288C>A upstream_gene_variant 0.13 rifampicin
rpoB 763094 c.3288G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763501 p.Asp44Glu missense_variant 0.19 rifampicin Uncertain significance
rpoC 763517 p.Lys50Arg missense_variant 0.22 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.32 rifampicin
rpoC 763534 c.165T>C synonymous_variant 0.35 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763550 p.Tyr61Asn missense_variant 0.36 rifampicin
rpoC 763555 c.186C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763615 c.246G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>G synonymous_variant 0.36 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.26 rifampicin
rpoC 763660 c.291T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.19 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.16 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.15 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.14 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.14 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.22 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.22 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>C synonymous_variant 0.34 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.39 rifampicin
rpoC 764706 p.Leu446Gln missense_variant 0.39 rifampicin Uncertain significance
rpoC 764716 c.1347G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764722 c.1353G>C synonymous_variant 0.34 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764759 p.Asn464Asp missense_variant 0.26 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.13 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 778979 c.-74G>T upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Uncertain significance
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781796 p.Met79Ile missense_variant 0.13 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.16 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.19 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.2 streptomycin
rpsL 781829 c.270G>T synonymous_variant 0.21 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.21 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.21 streptomycin Not assoc w R - Interim
rpsL 781838 c.279G>C synonymous_variant 0.22 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.24 streptomycin Not assoc w R - Interim
rpsL 781860 p.Ser101Thr missense_variant 0.24 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.24 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.24 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.24 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.23 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.19 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.19 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.18 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.13 streptomycin Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.37 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472107 n.262A>G non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.57 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.14 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472416 n.571C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472582 n.737G>A non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472583 n.738T>C non_coding_transcript_exon_variant 0.39 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472673 n.828T>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472674 n.829T>C non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.43 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.49 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.66 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473127 n.1282G>A non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.69 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473292 n.1447_1449delGGAinsTGGG non_coding_transcript_exon_variant 0.69 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474179 n.522C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474252 n.595T>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474253 n.596A>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474660 n.1003G>A non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474690 n.1033C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474790 n.1133C>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474869 n.1212G>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474938 n.1281G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475508 n.1851A>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475517 n.1860C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475548 n.1891C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475549 n.1892T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475562 n.1905C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid Uncertain significance
rrl 1475616 n.1959A>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475618 n.1961C>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475624 n.1967G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475626 n.1969T>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475634 n.1977G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475637 n.1982delC non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475692 n.2035G>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475740 n.2083G>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475747 n.2090A>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475760 n.2103C>A non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475767 n.2110G>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid Uncertain significance
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475781 n.2124T>C non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid
rrl 1475788 n.2131C>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.45 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.34 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.4 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.66 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.56 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.39 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476586 n.2929C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476613 n.2956G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.2 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476631 n.2974G>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rpsA 1833676 c.135A>G synonymous_variant 0.15 pyrazinamide
rpsA 1833679 c.138G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.14 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.16 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833893 p.Ala118Lys missense_variant 0.14 pyrazinamide
rpsA 1833896 p.Leu119Ile missense_variant 0.14 pyrazinamide
rpsA 1833905 p.Lys122Glu missense_variant 0.14 pyrazinamide
rpsA 1833912 p.Glu124Gly missense_variant 0.13 pyrazinamide
rpsA 1833915 p.Ala125Val missense_variant 0.13 pyrazinamide Uncertain significance
rpsA 1833921 p.Lys127Thr missense_variant 0.14 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.23 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.38 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.38 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.22 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834123 c.582C>G synonymous_variant 0.12 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834195 c.654G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834219 c.678C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834243 c.702G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.16 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834307 p.Asp256Asn missense_variant 0.15 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>T synonymous_variant 0.16 pyrazinamide
rpsA 1834357 c.816T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834360 c.819G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>G synonymous_variant 0.16 pyrazinamide
rpsA 1834384 c.843A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834395 p.Arg285Gln missense_variant 0.16 pyrazinamide
rpsA 1834408 c.867C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834427 p.Ile296Val missense_variant 0.13 pyrazinamide Uncertain significance
rpsA 1834432 c.891G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCTT synonymous_variant 0.16 pyrazinamide
rpsA 1834456 c.915T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834486 p.Glu315Asp missense_variant 0.15 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.16 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155643 p.Lys157Gln missense_variant 0.12 isoniazid
katG 2155655 p.Lys153Gln missense_variant 0.13 isoniazid Uncertain significance
katG 2155671 c.441G>C synonymous_variant 0.14 isoniazid
katG 2155674 c.438G>C synonymous_variant 0.15 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.14 isoniazid
katG 2155689 c.421_423delTTGinsCTC synonymous_variant 0.16 isoniazid Not assoc w R - Interim
katG 2155716 c.396T>C synonymous_variant 0.24 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.2 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.16 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.13 isoniazid
katG 2155766 p.His116Tyr missense_variant 0.16 isoniazid Uncertain significance
katG 2155776 c.336C>G synonymous_variant 0.15 isoniazid
katG 2155785 c.327T>C synonymous_variant 0.16 isoniazid
katG 2156591 c.-480T>G upstream_gene_variant 0.29 isoniazid Uncertain significance
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
ribD 2987172 p.Ser112Gly missense_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
rpoA 3877949 p.Thr187Ala missense_variant 0.9 rifampicin Uncertain significance
clpC1 4038773 c.1932T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038794 c.1909_1911delAGCinsTCG synonymous_variant 0.13 pyrazinamide
clpC1 4038801 p.Tyr635Phe missense_variant 0.13 pyrazinamide
clpC1 4038810 p.Gln632Pro missense_variant 0.13 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.13 pyrazinamide
clpC1 4038826 p.Ile627Val missense_variant 0.12 pyrazinamide
clpC1 4039875 p.Asn277Arg missense_variant 0.14 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039901 c.804C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039925 c.780C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039940 c.765G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040000 p.His235Lys missense_variant 0.24 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040010 p.Ala232Asp missense_variant 0.3 pyrazinamide Uncertain significance
clpC1 4040015 c.690G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.38 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040063 c.642G>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040066 c.639G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040069 c.636G>C synonymous_variant 0.36 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040093 c.612C>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040117 c.588A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040129 c.576C>G synonymous_variant 0.12 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R