TB-Profiler result

Run: SRR10315556
Summary

Run ID: SRR10315556

Sample name:

Date: 2024-10-05T12:55:34.236592

Number of reads: 3217375

Percentage reads mapped: 52.68

Median coverage: 98.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575907 p.Ala187Val missense_variant 1.0 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
rpoB 762065 c.2259T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762071 p.Asp755Glu missense_variant 0.17 rifampicin
rpoB 762080 c.2274G>C synonymous_variant 0.25 rifampicin
rpoB 762085 p.Ala760Glu missense_variant 0.29 rifampicin
rpoB 762089 c.2283G>A synonymous_variant 0.29 rifampicin
rpoB 762110 c.2304G>C synonymous_variant 0.3 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.27 rifampicin Uncertain significance
rpoB 762122 p.Asp772Glu missense_variant 0.28 rifampicin
rpoB 762125 c.2319G>A synonymous_variant 0.28 rifampicin
rpoB 762126 p.Val774Ser missense_variant 0.28 rifampicin
rpoB 762134 c.2328C>T synonymous_variant 0.32 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.37 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762156 p.Val784Ile missense_variant 0.39 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762177 p.Arg791Thr missense_variant 0.38 rifampicin
rpoB 762181 p.Asp792Ala missense_variant 0.37 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762200 c.2394C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.35 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762234 p.Pro810Ser missense_variant 0.2 rifampicin
rpoB 762239 c.2433G>A synonymous_variant 0.19 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.18 rifampicin
rpoB 762855 p.Val1017Ile missense_variant 0.17 rifampicin
rpoB 762858 p.Thr1018Ser missense_variant 0.17 rifampicin
rpoC 762863 c.-507T>G upstream_gene_variant 0.17 rifampicin
rpoB 762871 p.Met1022Thr missense_variant 0.17 rifampicin
rpoB 762878 p.Ile1024Met missense_variant 0.17 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.17 rifampicin Uncertain significance
rpoB 762887 c.3081G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762926 c.-444C>G upstream_gene_variant 0.31 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.4 rifampicin
rpoC 762971 c.-399G>C upstream_gene_variant 0.43 rifampicin
rpoC 762980 c.-390T>C upstream_gene_variant 0.45 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.42 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763005 p.Cys1067Val missense_variant 0.39 rifampicin
rpoB 763014 p.Met1070Leu missense_variant 0.39 rifampicin
rpoB 763017 p.Gln1071Glu missense_variant 0.39 rifampicin
rpoC 763022 c.-348C>T upstream_gene_variant 0.4 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763038 p.Thr1078Ala missense_variant 0.42 rifampicin
rpoC 763043 c.-327G>C upstream_gene_variant 0.43 rifampicin
rpoB 763053 c.3247T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763067 c.-303C>G upstream_gene_variant 0.4 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763077 p.Val1091Thr missense_variant 0.38 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 0.22 rifampicin
rpoC 763109 c.-261C>T upstream_gene_variant 0.18 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763589 p.Ile74Val missense_variant 0.13 rifampicin
rpoC 763598 p.Arg77Lys missense_variant 0.14 rifampicin
rpoC 763606 c.237C>T synonymous_variant 0.13 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763630 c.261G>T synonymous_variant 0.13 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763648 c.279C>T synonymous_variant 0.2 rifampicin
rpoC 763657 p.Glu96Asp missense_variant 0.21 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763663 c.294C>G synonymous_variant 0.21 rifampicin
rpoC 763666 c.297G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.22 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.14 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 763718 p.Leu117Val missense_variant 0.12 rifampicin
rpoC 763723 c.354G>C synonymous_variant 0.12 rifampicin
rpoC 763724 p.Asp119Asn missense_variant 0.12 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.12 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.12 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.13 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.13 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.13 rifampicin
rpoC 763772 p.Val135Met missense_variant 0.12 rifampicin
rpoC 764485 c.1116G>C synonymous_variant 0.2 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.18 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>T synonymous_variant 0.2 rifampicin
rpoC 764509 c.1140G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764512 c.1143G>C synonymous_variant 0.19 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.21 rifampicin
rpoC 764543 p.Thr392Ala missense_variant 0.29 rifampicin
rpoC 764548 c.1179G>C synonymous_variant 0.3 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764573 p.Leu402Ile missense_variant 0.3 rifampicin
rpoC 764578 c.1209C>G synonymous_variant 0.29 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.3 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.3 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.31 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.3 rifampicin
rpoC 764605 c.1236G>T synonymous_variant 0.31 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472068 n.223T>G non_coding_transcript_exon_variant 0.15 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.42 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.76 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.76 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.75 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.77 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472412 n.567A>G non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472416 n.571C>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472427 n.582T>G non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.24 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472436 n.591G>T non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472437 n.592T>G non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472438 n.593T>C non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472448 n.603T>C non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472449 n.604C>T non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472450 n.605A>C non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472451 n.606C>T non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472462 n.617T>G non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472474 n.629C>G non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472476 n.631A>G non_coding_transcript_exon_variant 0.27 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472484 n.639A>T non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472513 n.668T>C non_coding_transcript_exon_variant 0.53 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472647 n.802C>T non_coding_transcript_exon_variant 0.76 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472673 n.828_837delTTTCCTTCCTinsGGCCACCCG non_coding_transcript_exon_variant 0.64 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472686 n.841G>T non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472690 n.845C>T non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472707 n.862A>T non_coding_transcript_exon_variant 0.62 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.61 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.67 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.67 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.73 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.63 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.68 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.66 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.66 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.69 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.61 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.6 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473288 n.1443C>G non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473289 n.1444_1445insTTTTG non_coding_transcript_exon_variant 0.55 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473293 n.1449delA non_coding_transcript_exon_variant 0.54 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.55 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.55 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.54 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474271 n.614A>G non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474272 n.615C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474275 n.618T>G non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474288 n.631_647delCCTTTTCCTCTCCGGAGinsT non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474363 n.706A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474365 n.708G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474383 n.726G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474384 n.727C>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474467 n.810A>G non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474483 n.826C>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474528 n.871T>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474529 n.872A>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474540 n.883T>C non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474541 n.884G>T non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474551 n.894G>A non_coding_transcript_exon_variant 0.66 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474634 n.977T>C non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474636 n.979A>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid
rrl 1474674 n.1018delC non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1052G>A non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1474711 n.1054_1060delGGTGTAAinsTAGGTGT non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.84 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474801 n.1144G>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474802 n.1145T>C non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.77 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474901 n.1244A>G non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474933 n.1276A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474934 n.1277C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475673 n.2016T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475686 n.2029C>G non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1475696 n.2039T>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475703 n.2046A>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475715 n.2058G>C non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475751 n.2094C>A non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475760 n.2103C>A non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475762 n.2105_2106delGCinsTCCTTGT non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1475764 n.2107A>G non_coding_transcript_exon_variant 0.68 capreomycin
linezolid Uncertain significance
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1475767 n.2110G>T non_coding_transcript_exon_variant 0.67 capreomycin
linezolid Uncertain significance
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475945 n.2288C>A non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.53 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475995 n.2338G>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475998 n.2341C>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476000 n.2343G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.18 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.17 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.18 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.69 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.72 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.69 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.59 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476513 n.2856G>T non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476542 n.2885T>C non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476603 n.2946G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.15 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833949 c.408T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.35 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.35 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.35 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834025 p.Gln162Ala missense_variant 0.33 pyrazinamide
rpsA 1834039 c.498C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834040 p.Lys167Arg missense_variant 0.34 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.37 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834195 c.654G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834228 c.687C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834246 c.705G>T synonymous_variant 0.29 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.35 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834307 p.Asp256Gln missense_variant 0.36 pyrazinamide
rpsA 1834312 c.771G>A synonymous_variant 0.36 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.34 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834360 c.819G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834395 p.ArgHis285GlnAla missense_variant 0.2 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.11 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 0.99 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
clpC1 4039966 p.Leu247Ile missense_variant 0.13 pyrazinamide
clpC1 4039981 p.Leu242Ile missense_variant 0.2 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.23 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040042 c.663C>T synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040057 c.648C>T synonymous_variant 0.22 pyrazinamide
clpC1 4040066 c.639G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040081 c.624C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040090 c.615T>G synonymous_variant 0.19 pyrazinamide
clpC1 4040096 c.609G>C synonymous_variant 0.17 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407620 p.Tyr195His missense_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R