TB-Profiler result

Run: ERR550636
Summary

Run ID: ERR550636

Sample name:

Date: 2024-03-25T18:39:27.449156

Number of reads: 1232060

Percentage reads mapped: 79.17

Median coverage: 43.0

Strain: lineage4.1.1.3

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.97
lineage4.1.1.3 Euro-American (X-type) RD193 0.98
lineage4 Euro-American None 1.0
lineage4.1.1 Euro-American (X-type) None 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embA c.-16C>G Uncertain significance Mutation from literature
embB p.Met306Ile Assoc w R
p.His312Arg Mutation from literature
pyrazinamide pncA p.Arg154Gly Assoc w R
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
n.878G>A Assoc w R - Interim
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine ald c.464delG Mutation from literature
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
ethA c.1192_1194dupGTG Mutation from literature
c.869dupA Assoc w R
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 0.89 rifampicin Assoc w R
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance Mutation from literature
rrs 1472723 n.878G>A non_coding_transcript_exon_variant 0.8 streptomycin Assoc w R - Interim
inhA 1673425 c.-777C>T upstream_gene_variant 1.0 ethionamide Assoc w R Alias fabG1_c.-15C>T
isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
pncA 2288782 p.Arg154Gly missense_variant 1.0 pyrazinamide Assoc w R
ald 3087278 c.464delG frameshift_variant 1.0 cycloserine Mutation from literature
embA 4243217 c.-16C>G upstream_gene_variant 1.0 ethambutol Uncertain significance Mutation from literature
embB 4247431 p.Met306Ile missense_variant 0.78 ethambutol Assoc w R
embB 4247448 p.His312Arg missense_variant 0.24 ethambutol Mutation from literature
ethA 4326279 c.1192_1194dupGTG conservative_inframe_insertion 0.96 ethionamide Mutation from literature
ethA 4326604 c.869dupA frameshift_variant 1.0 ethionamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6178 c.939C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6215 p.Ser326Thr missense_variant 0.33 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6235 c.996C>A synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.37 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.36 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6334 c.-968G>A upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6346 c.-956C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6406 c.1167C>T synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6413 c.-889C>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6766 c.-536G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6778 c.-524C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6794 p.Ile519Leu missense_variant 0.2 levofloxacin
moxifloxacin
gyrB 6797 p.Gly520Thr missense_variant 0.2 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.19 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7442 c.141G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8267 c.966G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8690 c.1389C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9128 c.1827C>A synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9134 c.1833C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.17 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9147 p.Gly616Ser missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9153 p.Thr618Glu missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9179 c.1878C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9268 p.Asn656Ser missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 9315 c.2014C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
ccsA 620288 p.Arg133Gln missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620352 c.462C>T synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>A synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
Rv0565c 656328 c.1143G>A synonymous_variant 0.17 ethionamide
Rv0565c 656349 c.1122G>A synonymous_variant 0.16 ethionamide
Rv0565c 656358 c.1113T>C synonymous_variant 0.17 ethionamide Not assoc w R - Interim
Rv0565c 656364 c.1107T>C synonymous_variant 0.17 ethionamide
Rv0565c 656367 c.1101_1104delTCGGinsGC frameshift_variant&synonymous_variant 0.19 ethionamide Uncertain significance
Rv0565c 656371 p.Pro367His missense_variant 0.19 ethionamide
Rv0565c 656375 c.1095_1096insAA frameshift_variant 0.19 ethionamide Uncertain significance
Rv0565c 656383 p.Val363Thr missense_variant 0.17 ethionamide
Rv0565c 656391 c.1080C>G synonymous_variant 0.17 ethionamide
Rv0565c 656400 c.1071G>T synonymous_variant 0.21 ethionamide
Rv0565c 656406 c.1065G>T synonymous_variant 0.18 ethionamide
Rv0565c 656412 c.1059T>G synonymous_variant 0.19 ethionamide
Rv0565c 656418 c.1053A>G synonymous_variant 0.2 ethionamide
Rv0565c 656423 c.1048T>C synonymous_variant 0.18 ethionamide
Rv0565c 656424 c.1047G>A synonymous_variant 0.18 ethionamide
Rv0565c 656430 c.1041C>G synonymous_variant 0.19 ethionamide
Rv0565c 656448 c.1023T>C synonymous_variant 0.19 ethionamide
Rv0565c 657269 p.Ser68Pro missense_variant 0.89 ethionamide Uncertain significance
hadA 732308 p.Val127Ile missense_variant 0.14 isoniazid
hadA 732319 c.390G>A synonymous_variant 0.15 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.14 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.16 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.16 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.21 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.23 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.24 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.25 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.24 isoniazid
nusG 734532 c.279A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.19 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.19 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>T synonymous_variant 0.21 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.2 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.2 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.18 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.2 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.18 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.17 rifampicin
rpoB 760085 c.279C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760091 c.285G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760100 c.294G>A synonymous_variant 0.18 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.18 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760139 c.333A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.18 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.25 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.22 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.2 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.19 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.19 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.2 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.2 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.2 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>G synonymous_variant 0.27 rifampicin
rpoB 760463 c.657C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.26 rifampicin
rpoB 760514 c.708C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760520 c.714C>G synonymous_variant 0.23 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.23 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.2 rifampicin
rpoB 760547 c.741G>T synonymous_variant 0.2 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.18 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760805 c.999G>C synonymous_variant 0.19 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.18 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.18 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.24 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.24 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ser missense_variant 0.26 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.28 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.29 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.29 rifampicin
rpoB 760928 c.1122G>T synonymous_variant 0.27 rifampicin
rpoB 760931 c.1125C>G synonymous_variant 0.28 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.27 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.19 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.22 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761657 c.1851C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761669 c.1863C>T synonymous_variant 0.2 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.23 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.23 rifampicin
rpoB 761717 c.1911C>G synonymous_variant 0.23 rifampicin
rpoB 761723 c.1917_1919delAGAinsT frameshift_variant&missense_variant 0.23 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.23 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.25 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.25 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.22 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.22 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.21 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.19 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.16 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.16 rifampicin
rpoB 761969 c.2163G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.22 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.21 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.23 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.23 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.23 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.21 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.19 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.22 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762285 p.Arg827Cys missense_variant 0.8 rifampicin Uncertain significance
rpoB 762293 c.2487T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762347 c.2541T>C synonymous_variant 0.2 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.2 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.22 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.19 rifampicin
rpoC 762407 c.-963G>A upstream_gene_variant 0.22 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.22 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.24 rifampicin
rpoB 762836 c.3030C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.24 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.24 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.16 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.16 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763205 c.-165G>C upstream_gene_variant 0.16 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.17 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.17 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.25 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763624 c.255C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.25 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763741 c.372C>T synonymous_variant 0.17 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.17 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.16 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>T synonymous_variant 0.15 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764213 p.Arg282Lys missense_variant 0.15 rifampicin Uncertain significance
rpoC 764257 c.888G>C synonymous_variant 0.2 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.19 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.19 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.19 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.2 rifampicin
rpoC 764338 c.969G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.3 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.3 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.32 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.26 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.21 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.3 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.26 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.26 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.18 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765370 c.2001G>T synonymous_variant 0.16 rifampicin
rpoC 765371 c.2002C>T synonymous_variant 0.16 rifampicin
rpoC 765379 c.2010G>T synonymous_variant 0.17 rifampicin
rpoC 765383 c.2014_2016delATGinsCT frameshift_variant&missense_variant 0.18 rifampicin
rpoC 765394 c.2025G>A synonymous_variant 0.2 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.2 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.19 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.2 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765466 c.2097C>T synonymous_variant 0.18 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.23 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.23 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.28 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.29 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.28 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.25 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.3 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.3 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765688 c.2319G>A synonymous_variant 0.28 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.27 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.3 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.29 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.25 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.27 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.27 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.28 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.28 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.25 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.18 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766312 c.2943T>G synonymous_variant 0.19 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.21 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.16 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.16 rifampicin
rpoC 766366 c.2997C>G synonymous_variant 0.16 rifampicin
rpoC 766369 c.3000C>G synonymous_variant 0.16 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.17 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.17 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766390 c.3021C>T synonymous_variant 0.16 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.16 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.16 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.16 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.16 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.19 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.22 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.17 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.21 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.21 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.23 rifampicin
rpoC 766693 c.3324C>T synonymous_variant 0.21 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.25 rifampicin
rpoC 766801 c.3432C>A synonymous_variant 0.24 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.29 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.36 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.34 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.33 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>A synonymous_variant 0.3 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.29 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.26 rifampicin
rpoC 767065 c.3696G>T synonymous_variant 0.28 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.19 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.17 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781435 c.-125G>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781679 c.120C>T synonymous_variant 0.19 streptomycin Not assoc w R - Interim
rpsL 781682 c.123T>C synonymous_variant 0.19 streptomycin
rpsL 781712 c.153G>A synonymous_variant 0.19 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.19 streptomycin
rpsL 781718 c.159C>A synonymous_variant 0.19 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.21 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.22 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.23 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.25 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.25 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.25 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.25 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.25 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.26 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.27 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.28 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.24 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.23 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.23 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.17 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.15 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.14 streptomycin Uncertain significance
rplC 800219 c.-590T>C upstream_gene_variant 0.97 linezolid
rplC 800594 c.-215C>T upstream_gene_variant 0.13 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.15 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.15 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.14 linezolid
fbiC 1304817 c.1887T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304869 c.1939C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304880 c.1950C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.18 clofazimine
pretomanid
delamanid
sigE 1364949 c.537C>T synonymous_variant 0.16 pyrazinamide
sigE 1364950 p.Ala180Ser missense_variant 0.15 pyrazinamide
sigE 1364961 c.549A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
sigE 1364964 c.552T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
sigE 1364982 p.Leu190Phe missense_variant 0.15 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.15 pyrazinamide
sigE 1365006 c.594T>C synonymous_variant 0.16 pyrazinamide
atpE 1461119 c.75T>C synonymous_variant 0.26 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.28 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.26 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.26 bedaquiline
atpE 1461155 c.111C>G synonymous_variant 0.26 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.26 bedaquiline Uncertain significance
atpE 1461182 c.138A>G synonymous_variant 0.23 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.23 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.21 bedaquiline
atpE 1461212 c.168C>G synonymous_variant 0.2 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.2 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.18 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.18 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1473831 n.174G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473966 n.309T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474036 n.379G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475201 n.1544G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475446 n.1789G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.18 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.19 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833667 c.126C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1833793 c.252C>T synonymous_variant 0.15 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.21 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.18 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834345 c.804C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.24 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.19 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.18 pyrazinamide
rpsA 1834775 p.Ala412Asn missense_variant 0.16 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.16 pyrazinamide
tsnR 1853360 c.-246G>A upstream_gene_variant 0.24 linezolid
tsnR 1853361 c.-245T>C upstream_gene_variant 0.25 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.23 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.23 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.21 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.2 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>T upstream_gene_variant 0.16 isoniazid
kasA 2518483 c.369C>T synonymous_variant 0.15 isoniazid
kasA 2518488 p.Ser125Thr missense_variant 0.17 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.17 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.17 isoniazid
kasA 2518510 c.396C>T synonymous_variant 0.17 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.17 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.19 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.2 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.16 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.18 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.17 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.18 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.18 isoniazid
kasA 2518606 c.492G>C synonymous_variant 0.2 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.21 isoniazid
kasA 2518618 c.504G>T synonymous_variant 0.19 isoniazid
kasA 2518621 c.507G>C synonymous_variant 0.2 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.21 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.21 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.18 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.28 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.28 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.27 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.24 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.23 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.21 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.19 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.17 isoniazid
kasA 2518837 c.723G>A synonymous_variant 0.17 isoniazid
kasA 2518846 c.732G>C synonymous_variant 0.17 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.16 isoniazid
Rv2477c 2782966 c.1077C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782975 c.1068C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782984 c.1059T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783015 p.Ser343Thr missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783554 c.489C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783695 c.348C>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783770 c.273G>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3065457 c.735A>T synonymous_variant 0.14 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065979 c.213T>C synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065985 c.207C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065993 p.Val67Ile missense_variant 0.14 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066003 c.189C>T synonymous_variant 0.15 ethambutol
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin
isoniazid
thyA 3073860 c.612C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073866 c.606C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073872 p.Ile200Met missense_variant 0.15 para-aminosalicylic_acid
thyA 3073889 p.Ser195Ala missense_variant 0.16 para-aminosalicylic_acid
thyA 3073890 p.Leu194Phe missense_variant 0.16 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.16 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073968 c.504C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.15 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624063 p.Asn283Ser missense_variant 0.19 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625656 c.958T>C synonymous_variant 0.19 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3625852 c.762A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625855 c.759G>A synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625858 c.-948C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625864 c.-954T>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625909 c.-999T>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627263 c.-650C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3627269 c.81G>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627277 c.73C>T synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.21 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.16 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.25 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.25 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.26 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.25 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.24 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.23 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.22 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.19 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.19 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.19 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.19 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.2 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.2 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.21 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.18 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.2 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.22 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.21 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.2 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.19 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.21 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.19 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>G synonymous_variant 0.18 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.18 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.32 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>T synonymous_variant 0.41 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.27 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.27 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.26 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.23 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.23 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.22 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.19 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.19 rifampicin
rpoA 3878769 c.-262C>A upstream_gene_variant 0.21 rifampicin
rpoA 3878782 c.-275G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878809 c.-302T>C upstream_gene_variant 0.35 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.28 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.31 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.29 rifampicin
rpoA 3879050 c.-543A>C upstream_gene_variant 0.23 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.23 rifampicin
clpC1 4038308 c.2397G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.3 pyrazinamide
clpC1 4038338 c.2367C>T synonymous_variant 0.3 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.22 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.19 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.19 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038677 c.2028G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038683 c.2022T>G synonymous_variant 0.19 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.19 pyrazinamide
clpC1 4038929 c.1776G>A synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039034 c.1671C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.19 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039610 c.1095G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039634 c.1071G>A synonymous_variant 0.23 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.17 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.14 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040444 c.261C>T synonymous_variant 0.13 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
panD 4044150 c.132A>C synonymous_variant 0.14 pyrazinamide
panD 4044159 c.123C>G synonymous_variant 0.17 pyrazinamide
panD 4044162 c.120A>G synonymous_variant 0.16 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.17 pyrazinamide
panD 4044174 c.108C>G synonymous_variant 0.15 pyrazinamide
panD 4044177 c.105C>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
panD 4044188 c.94T>C synonymous_variant 0.16 pyrazinamide
panD 4044189 c.93C>T synonymous_variant 0.16 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.17 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.17 pyrazinamide
panD 4044746 c.-467_-465delGTGinsAC upstream_gene_variant 0.15 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.15 pyrazinamide
panD 4044848 c.-567T>G upstream_gene_variant 0.14 pyrazinamide
glpK 4138547 c.1209C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138580 c.1176C>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240178 c.316T>C synonymous_variant 0.22 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.19 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.19 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.18 ethambutol
embC 4240798 c.936C>T synonymous_variant 0.19 ethambutol
embC 4240813 p.Phe317Leu missense_variant 0.16 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.17 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.16 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
embA 4245056 c.1824C>G synonymous_variant 0.19 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.18 ethambutol
embA 4245065 c.1833G>A synonymous_variant 0.18 ethambutol
embA 4245093 p.Ile621Val missense_variant 0.21 ethambutol Uncertain significance
embA 4245101 c.1869G>C synonymous_variant 0.24 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.3 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.29 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.26 ethambutol
embA 4245186 p.Thr652Ala missense_variant 0.25 ethambutol
embA 4245198 p.Leu656Ala missense_variant 0.26 ethambutol
embA 4245206 c.1974A>C synonymous_variant 0.24 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.24 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.24 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
embA 4245245 c.2013C>A synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247428 c.915C>T synonymous_variant 0.2 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.22 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4247446 c.933C>T synonymous_variant 0.24 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.21 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.2 ethambutol
embB 4247485 c.972C>T synonymous_variant 0.22 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.2 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.22 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.22 ethambutol
embB 4247544 p.Ser344Thr missense_variant 0.2 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.18 ethambutol
embB 4248001 c.1488C>T synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248007 c.1494C>G synonymous_variant 0.2 ethambutol
embB 4248008 c.1495C>T synonymous_variant 0.2 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.17 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.17 ethambutol Uncertain significance
embB 4248044 p.Lys511Ser missense_variant 0.18 ethambutol
embB 4248052 c.1539G>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4248055 c.1542G>C synonymous_variant 0.18 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.18 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.17 ethambutol
embB 4248118 c.1605T>A synonymous_variant 0.21 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.22 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.23 ethambutol
embB 4248149 c.1636_1638delACCinsGG frameshift_variant&missense_variant 0.21 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248160 c.1647C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248169 c.1656C>A synonymous_variant 0.18 ethambutol
embB 4248172 c.1659G>C synonymous_variant 0.16 ethambutol
embB 4248175 c.1662G>C synonymous_variant 0.16 ethambutol
embB 4248178 c.1665C>T synonymous_variant 0.15 ethambutol
embB 4248181 c.1668C>T synonymous_variant 0.15 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.16 ethambutol
embB 4248214 c.1701C>A synonymous_variant 0.17 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4248226 c.1713G>C synonymous_variant 0.18 ethambutol
embB 4249408 c.2895G>A synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407798 c.405G>T synonymous_variant 1.0 streptomycin Not assoc w R