TB-Profiler result

Run: ERR9787153
Summary

Run ID: ERR9787153

Sample name:

Date: 2024-04-16T05:19:09.832054

Number of reads: 2672762

Percentage reads mapped: 82.28

Median coverage: 110.0

Strain: lineage6.1.3

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage6.1.3 West-Africa 2 RD702 0.99
lineage6 West-Africa 2 RD702 0.94
lineage6.1 West-Africa 2 RD702 0.38
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embC p.Ala307Thr Uncertain significance Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine pepQ c.592_594delGCCinsCG Assoc w R - Interim
para-aminosalicylic_acid
delamanid fbiC c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1126_1128delGAGinsCA Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline pepQ c.592_594delGCCinsCG Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.21 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1304056 c.1126_1128delGAGinsCA frameshift_variant&missense_variant 0.2 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pepQ 2859825 c.592_594delGCCinsCG frameshift_variant&synonymous_variant 0.17 bedaquiline Assoc w R - Interim Includes data from one site that only submitted resistant strains, which may have inflated the PPV
clofazimine Assoc w R - Interim
embC 4240781 p.Ala307Thr missense_variant 0.89 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6214 c.975G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Asn missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6362 c.-940T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6446 p.Ala403Ser missense_variant 0.94 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6680 c.1441C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6700 c.-602T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.25 levofloxacin
moxifloxacin
gyrA 6803 c.-499C>T upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6856 c.1617T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6889 c.-413G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6970 c.-332C>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 7012 c.1773G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7033 c.-269G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7162 c.-140C>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 7185 p.Ser649Phe missense_variant 0.85 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7412 c.111C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7436 c.135C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7442 c.141G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7463 c.162G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7532 c.231T>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7587 c.286C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8330 c.1029C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8339 c.1038A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8411 c.1110C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8447 c.1146C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8493 p.Leu398Phe missense_variant 0.84 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8603 c.1302A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8729 c.1428T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8731 p.Gly477Ala missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Asn missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8759 c.1458C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8767 p.Arg489Lys missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8796 c.1495_1497delATCinsGG frameshift_variant&missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8806 p.Asp502Gly missense_variant 0.79 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8813 p.Asp504Glu missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9062 c.1761C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9068 c.1767G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9083 c.1782G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 9113 c.1812C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9128 c.1827C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9147 p.Gly616Ser missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 9153 p.Thr618Glu missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 c.1903_1905delTCCinsAG frameshift_variant&synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9210 c.1909C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9263 c.1962C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9268 p.Asn656Ser missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9323 c.2022C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 1.0 isoniazid Not assoc w R
fgd1 491668 p.Lys296Glu missense_variant 0.95 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
ccsA 620198 p.Gln103Leu missense_variant 0.16 capreomycin
amikacin
kanamycin
Rv0565c 656432 p.Gly347Ser missense_variant 0.96 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
nusG 734614 p.Ala121Ser missense_variant 0.16 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.18 rifampicin
rpoB 760855 p.Thr350Ile missense_variant 0.87 rifampicin Uncertain significance
rpoB 760925 c.1119T>C synonymous_variant 0.16 rifampicin
rpoB 760969 p.Ser388Phe missense_variant 0.76 rifampicin
rpoB 760973 c.1167G>C synonymous_variant 0.23 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.27 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.23 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.18 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.19 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.17 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761231 c.1425C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761288 c.1482G>T synonymous_variant 0.18 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 1.0 rifampicin Not assoc w R
rpoB 761972 c.2166C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.17 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762110 c.2304G>C synonymous_variant 0.22 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.23 rifampicin Uncertain significance
rpoB 762128 c.2322G>C synonymous_variant 0.22 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.22 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.21 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762161 c.2355C>G synonymous_variant 0.25 rifampicin
rpoB 762167 c.2361T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.27 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.27 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.22 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.2 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.21 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.22 rifampicin
rpoC 762380 c.-990T>C upstream_gene_variant 0.2 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.21 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.18 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.17 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.18 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.18 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.18 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.16 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.15 rifampicin
rpoB 762630 p.Ala942Thr missense_variant 0.16 rifampicin Uncertain significance
rpoC 762641 c.-729G>C upstream_gene_variant 0.17 rifampicin
rpoC 762710 c.-660G>A upstream_gene_variant 0.18 rifampicin
rpoC 762728 c.-642C>G upstream_gene_variant 0.19 rifampicin
rpoC 762749 c.-621C>G upstream_gene_variant 0.22 rifampicin
rpoB 762753 c.2947T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762759 p.Cys985Ala missense_variant 0.21 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.22 rifampicin Uncertain significance
rpoB 762795 p.Asp997Asn missense_variant 0.25 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.25 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.24 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762868 p.Tyr1021Phe missense_variant 0.24 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.18 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763537 c.168C>G synonymous_variant 0.19 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.19 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763663 c.294C>G synonymous_variant 0.19 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763672 c.303C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.21 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.21 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.23 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.24 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.23 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.27 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.27 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.28 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.29 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.31 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.3 rifampicin
rpoC 763851 p.Ala161Gly missense_variant 0.32 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.33 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.33 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.31 rifampicin
rpoC 763876 c.507A>G synonymous_variant 0.31 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.29 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.29 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.28 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763906 c.537C>G synonymous_variant 0.3 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.27 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763996 c.627T>C synonymous_variant 0.26 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764024 c.655T>C synonymous_variant 0.23 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.23 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.23 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.2 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764119 c.750G>A synonymous_variant 0.2 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.21 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.25 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.26 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764242 c.873C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764245 c.876C>T synonymous_variant 0.25 rifampicin
rpoC 764246 c.877_879delCTCinsTG frameshift_variant&missense_variant 0.25 rifampicin
rpoC 764257 c.888G>C synonymous_variant 0.26 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.28 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.28 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.29 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.29 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.28 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.17 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.17 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.17 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.15 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.2 rifampicin
rpoC 764749 c.1380G>C synonymous_variant 0.18 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.18 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.18 rifampicin
rpoC 764932 c.1563C>G synonymous_variant 0.17 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.17 rifampicin
rpoC 765079 c.1710T>C synonymous_variant 0.17 rifampicin
rpoC 765082 c.1713G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.18 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765100 c.1731G>C synonymous_variant 0.19 rifampicin
rpoC 765103 c.1734G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765454 c.2085C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765466 c.2097C>T synonymous_variant 0.21 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765517 c.2148C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>G synonymous_variant 0.25 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.23 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.23 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.23 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.2 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765694 c.2325G>C synonymous_variant 0.18 rifampicin
rpoC 765727 c.2358T>C synonymous_variant 0.16 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.16 rifampicin Uncertain significance
rpoC 765784 c.2415C>G synonymous_variant 0.16 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.16 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.17 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.17 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765892 c.2523T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765904 c.2535C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.16 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.16 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.16 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.16 rifampicin
rpoC 766083 p.Ala905Glu missense_variant 0.16 rifampicin
rpoC 766151 p.Asp928Asn missense_variant 0.15 rifampicin
rpoC 766207 c.2838T>C synonymous_variant 0.17 rifampicin
rpoC 766231 c.2862T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 766273 c.2904T>C synonymous_variant 0.17 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.17 rifampicin
rpoC 766312 c.2943T>G synonymous_variant 0.21 rifampicin
rpoC 766321 c.2952C>G synonymous_variant 0.2 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.22 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.2 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.18 rifampicin
rpoC 766390 c.3021C>A synonymous_variant 0.18 rifampicin
rpoC 766402 c.3033C>G synonymous_variant 0.18 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.17 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.21 rifampicin
rpoC 766447 c.3078T>G synonymous_variant 0.17 rifampicin
rpoC 766459 c.3090G>T synonymous_variant 0.18 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.22 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.22 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.24 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.24 rifampicin
rpoC 766525 c.3156G>C synonymous_variant 0.24 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.25 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.29 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.27 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.27 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.27 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.24 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.23 rifampicin
rpoC 766635 p.Phe1089Tyr missense_variant 0.23 rifampicin
rpoC 766645 p.Glu1092Asp missense_variant 0.22 rifampicin Not assoc w R
rpoC 766651 c.3282T>C synonymous_variant 0.21 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.19 rifampicin
rpoC 766658 c.3289_3291delCGGinsGA frameshift_variant&missense_variant 0.19 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.21 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.18 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.24 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.23 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.18 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.23 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.23 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.22 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766924 c.3555G>A synonymous_variant 0.2 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.21 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.21 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.19 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.2 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.23 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.24 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.23 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>T synonymous_variant 0.23 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.2 rifampicin
rpoC 767209 c.3840T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.17 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.18 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.19 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.21 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.21 streptomycin
rpsL 781724 c.165G>C synonymous_variant 0.23 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.24 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.24 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.24 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.23 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.23 streptomycin
rpsL 781820 c.261G>T synonymous_variant 0.24 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.2 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.21 streptomycin Not assoc w R - Interim
rpsL 781838 c.279G>C synonymous_variant 0.21 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.21 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.19 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.18 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.18 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.18 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.18 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.17 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.18 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.18 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.19 streptomycin
rplC 800232 c.-577G>T upstream_gene_variant 1.0 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.15 linezolid
rplC 801156 c.348T>C synonymous_variant 0.16 linezolid
rplC 801174 c.366T>C synonymous_variant 0.18 linezolid
rplC 801210 c.402T>C synonymous_variant 0.18 linezolid
rplC 801222 c.414T>C synonymous_variant 0.18 linezolid
rplC 801228 c.420T>C synonymous_variant 0.18 linezolid
rplC 801249 c.441T>G synonymous_variant 0.19 linezolid
rplC 801255 c.447C>T synonymous_variant 0.19 linezolid
rplC 801264 c.456C>T synonymous_variant 0.18 linezolid
rplC 801276 c.468G>T synonymous_variant 0.17 linezolid
rplC 801279 c.471G>C synonymous_variant 0.17 linezolid
rplC 801282 c.474G>T synonymous_variant 0.17 linezolid
rplC 801385 c.577C>T synonymous_variant 0.17 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1303846 p.Phe306His missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303869 c.939T>C synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303878 c.948G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303908 c.978C>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303935 c.1005G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303965 c.1035G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303972 p.Gly348Arg missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304079 c.1149A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304081 p.Ala384Gly missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304086 p.Tyr386His missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304091 p.Asp387Glu missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304115 c.1185A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>C synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1304133 c.1203G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304154 c.1224G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304169 c.1239T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304172 c.1242G>C synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1304173 p.Val415Leu missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304193 c.1263G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304199 c.1269C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304622 c.1692C>T synonymous_variant 0.16 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304682 c.1752C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Glu missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304751 c.1821C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304760 c.1830G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304763 c.1833C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304766 c.1836C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304769 c.1839C>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304778 p.Asp616Glu missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304799 c.1869G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304802 c.1872G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304853 c.1923C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304905 p.Ala659Ser missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304934 c.2004C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304970 c.2040G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305001 p.Ile691Val missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305014 p.Thr695Ser missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305043 p.Ser705Thr missense_variant 0.15 clofazimine
pretomanid
delamanid
sigE 1364742 c.330A>G synonymous_variant 0.18 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.18 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.19 pyrazinamide
sigE 1364772 c.360G>T synonymous_variant 0.19 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.19 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.18 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.19 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.19 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.2 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.21 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.21 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.22 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.2 pyrazinamide
sigE 1364865 c.453G>T synonymous_variant 0.2 pyrazinamide
sigE 1364868 c.456T>C synonymous_variant 0.2 pyrazinamide
sigE 1364877 c.465G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.2 pyrazinamide Uncertain significance
sigE 1364898 c.486C>T synonymous_variant 0.2 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.22 pyrazinamide
sigE 1364950 c.538_540delGCAinsTG frameshift_variant&stop_gained 0.18 pyrazinamide Uncertain significance
Rv1258c 1406215 p.Leu376Met missense_variant 1.0 streptomycin
isoniazid
pyrazinamide
Rv1258c 1406685 p.Val219Ala missense_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
embR 1416633 p.Leu239Val missense_variant 1.0 ethambutol Uncertain significance
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
atpE 1460804 c.-241T>C upstream_gene_variant 0.19 bedaquiline
atpE 1460807 c.-238C>T upstream_gene_variant 0.18 bedaquiline
atpE 1461251 c.207G>T synonymous_variant 0.97 bedaquiline Not assoc w R - Interim
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472489 n.644A>G non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473943 n.286G>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474007 n.350A>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474029 n.372G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474060 n.403G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474447 n.790G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475637 n.1980T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475883 n.2226A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.18 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.18 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674406 p.Glu69Lys missense_variant 0.16 ethionamide
isoniazid
inhA 1674416 p.Ala72Asp missense_variant 0.16 ethionamide
isoniazid
inhA 1674428 p.Gly76Asp missense_variant 0.15 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674434 p.Val78Ala missense_variant 0.84 ethionamide Uncertain significance
isoniazid Not assoc w R
inhA 1674443 p.Ala81Glu missense_variant 0.17 ethionamide
isoniazid
inhA 1674450 c.249G>T synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674452 p.Ala84Glu missense_variant 0.21 ethionamide
isoniazid
inhA 1674465 c.264C>G synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674471 c.270G>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674504 c.303C>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674534 c.333G>A synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.16 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674639 c.438C>T synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674655 c.454_456delAGCinsTCG synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674690 c.489C>G synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674741 c.540C>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674742 p.Lys181Pro missense_variant 0.22 ethionamide
isoniazid
inhA 1674756 c.555T>G synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674774 c.573A>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674780 c.579T>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674801 c.600T>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674816 c.615T>C synonymous_variant 0.26 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674846 p.Ile215Met missense_variant 0.26 ethionamide
isoniazid
rpsA 1833541 c.-1T>C upstream_gene_variant 0.17 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.18 pyrazinamide Uncertain significance
rpsA 1833595 c.54T>G synonymous_variant 0.21 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.22 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.26 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.23 pyrazinamide
rpsA 1833796 c.255G>A synonymous_variant 0.23 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.24 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.25 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834009 c.468C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834390 c.849G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.25 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834468 c.927A>C synonymous_variant 0.25 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834528 c.987T>G synonymous_variant 0.29 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.27 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834612 c.1071G>A synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834633 c.1092A>G synonymous_variant 0.19 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834657 c.1116G>A synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834690 c.1149T>C synonymous_variant 0.2 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2063121 c.1608A>T synonymous_variant 0.98 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518146 p.Phe11Tyr missense_variant 0.17 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.21 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.18 isoniazid
kasA 2518183 c.69G>A synonymous_variant 0.19 isoniazid
kasA 2518186 c.72G>C synonymous_variant 0.18 isoniazid
kasA 2518189 c.75C>T synonymous_variant 0.18 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.19 isoniazid
kasA 2518223 c.109T>C synonymous_variant 0.18 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.21 isoniazid
kasA 2518255 c.141A>G synonymous_variant 0.21 isoniazid
kasA 2518279 c.165T>C synonymous_variant 0.23 isoniazid
kasA 2518282 c.168A>G synonymous_variant 0.23 isoniazid
kasA 2518283 p.Ala57Pro missense_variant 0.23 isoniazid
kasA 2518297 c.183C>T synonymous_variant 0.25 isoniazid
kasA 2518300 c.186T>G synonymous_variant 0.25 isoniazid
kasA 2518312 p.Asp66Glu missense_variant 0.24 isoniazid
kasA 2518315 c.201G>C synonymous_variant 0.24 isoniazid
kasA 2518321 c.207C>T synonymous_variant 0.23 isoniazid
kasA 2518323 p.Ser70Asn missense_variant 0.23 isoniazid
kasA 2518334 c.220_222delCGAinsAG frameshift_variant&synonymous_variant 0.22 isoniazid
kasA 2518343 p.Met77Leu missense_variant 0.24 isoniazid
kasA 2518348 c.234A>C synonymous_variant 0.23 isoniazid
kasA 2518357 c.243G>C synonymous_variant 0.24 isoniazid
kasA 2518379 c.265T>C synonymous_variant 0.22 isoniazid
kasA 2518385 p.Gly91Ser missense_variant 0.19 isoniazid
kasA 2518390 c.276A>T synonymous_variant 0.19 isoniazid
kasA 2518396 c.282A>C synonymous_variant 0.17 isoniazid
kasA 2518403 p.Ser97Asn missense_variant 0.18 isoniazid
kasA 2518417 c.303G>C synonymous_variant 0.17 isoniazid
kasA 2518420 p.Glu102Asp missense_variant 0.17 isoniazid
kasA 2518426 c.312T>C synonymous_variant 0.17 isoniazid
kasA 2518439 c.325_327delGCCinsTG frameshift_variant&missense_variant 0.17 isoniazid
kasA 2518444 c.330T>C synonymous_variant 0.18 isoniazid
kasA 2518447 c.333T>G synonymous_variant 0.18 isoniazid
kasA 2518459 c.345T>G synonymous_variant 0.18 isoniazid
kasA 2518462 c.348A>G synonymous_variant 0.17 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.18 isoniazid
kasA 2518475 c.361A>C synonymous_variant 0.17 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.18 isoniazid
kasA 2518492 c.378C>T synonymous_variant 0.16 isoniazid
kasA 2518597 c.483C>G synonymous_variant 0.17 isoniazid
kasA 2518618 c.504G>A synonymous_variant 0.15 isoniazid
kasA 2518636 c.522C>T synonymous_variant 0.16 isoniazid
kasA 2518645 c.531G>A synonymous_variant 0.18 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.17 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.18 isoniazid
kasA 2518783 c.669T>G synonymous_variant 0.17 isoniazid
kasA 2518786 c.672G>A synonymous_variant 0.17 isoniazid
kasA 2518789 c.675G>T synonymous_variant 0.17 isoniazid
kasA 2518798 c.684G>T synonymous_variant 0.18 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.18 isoniazid
folC 2746948 c.651G>A synonymous_variant 0.17 para-aminosalicylic_acid
folC 2746966 c.633G>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2746975 c.624T>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2746979 p.Ala207Gly missense_variant 0.17 para-aminosalicylic_acid
folC 2746981 c.618T>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2746987 c.612T>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2746990 p.Asp203Glu missense_variant 0.17 para-aminosalicylic_acid
Rv2477c 2782885 c.1158G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782900 c.1143C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782913 p.Ser377Thr missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Gln missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>A synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783104 c.939C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783185 c.858G>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783209 c.834G>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783284 c.759G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783407 c.636C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783431 c.610_612delAGCinsGA frameshift_variant&missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783440 c.603T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783446 c.597A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783509 c.534C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783557 c.486T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783617 c.426G>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783626 c.415_417delGCGinsTC frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783659 c.384A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783704 c.339C>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 c.222A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859704 c.715T>C synonymous_variant 0.19 clofazimine
bedaquiline
pepQ 2859723 c.696T>C synonymous_variant 0.16 clofazimine Not assoc w R - Interim
bedaquiline
pepQ 2859765 c.654G>C synonymous_variant 0.18 clofazimine
bedaquiline
pepQ 2859778 p.Val214Asp missense_variant 0.17 clofazimine
bedaquiline
pepQ 2859781 p.Gln213Pro missense_variant 0.16 clofazimine
bedaquiline
pepQ 2859801 c.618G>C synonymous_variant 0.17 clofazimine
bedaquiline
pepQ 2859816 c.603G>C synonymous_variant 0.17 clofazimine
bedaquiline
pepQ 2859834 c.585T>C synonymous_variant 0.18 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
pepQ 2859857 p.Val188Met missense_variant 0.17 clofazimine
bedaquiline
pepQ 2859864 c.555T>G synonymous_variant 0.18 clofazimine Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
pepQ 2859870 c.549T>C synonymous_variant 0.18 clofazimine
bedaquiline
pepQ 2859873 c.546T>C synonymous_variant 0.18 clofazimine
bedaquiline
thyX 3067318 c.628C>A synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067322 c.624C>T synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067406 c.540A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067430 c.516C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067463 c.483C>T synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067470 p.Asn159Ser missense_variant 0.19 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067515 p.Ser144Ala missense_variant 0.19 para-aminosalicylic_acid
thyX 3067531 p.Ala139Thr missense_variant 0.16 para-aminosalicylic_acid
thyX 3067560 p.Arg129His missense_variant 0.15 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.17 para-aminosalicylic_acid
thyX 3067577 p.Glu123Asp missense_variant 0.19 para-aminosalicylic_acid
thyX 3067592 c.354G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067610 p.Lys112Ser missense_variant 0.18 para-aminosalicylic_acid
thyX 3067619 c.327A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067622 c.324C>T synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067742 c.204A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067762 p.Arg62Gly missense_variant 0.21 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.21 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067784 c.162C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067839 p.Val36Thr missense_variant 0.18 para-aminosalicylic_acid
thyX 3067841 c.105G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.17 para-aminosalicylic_acid
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3236c 3612143 p.Arg325His missense_variant 1.0 pyrazinamide Uncertain significance
lpqB 3624350 c.561G>T synonymous_variant 0.97 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625117 c.-207T>G upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625123 c.-213T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625138 c.-228C>G upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625693 c.-783G>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625744 c.870G>A synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.17 bedaquiline
rifampicin Uncertain significance
lpqB 3625759 c.-849G>A upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625798 c.-888G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625822 c.-912C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625837 c.777C>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625864 c.-954T>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625867 c.747A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625891 c.-981G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625900 c.-990G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625909 c.-999T>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625912 c.702G>C synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3625915 c.699G>C synonymous_variant 0.17 bedaquiline
rifampicin
mtrB 3625930 c.684C>G synonymous_variant 0.17 bedaquiline
rifampicin
mtrB 3625967 p.Ala216Ile missense_variant 0.17 bedaquiline
rifampicin
mtrB 3625978 c.636T>C synonymous_variant 0.17 bedaquiline
rifampicin
mtrB 3625988 p.Thr209Gln missense_variant 0.17 bedaquiline
rifampicin
mtrB 3625993 c.621G>C synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3625999 c.615A>G synonymous_variant 0.19 bedaquiline
rifampicin
mtrB 3626006 p.Ser203Asn missense_variant 0.18 bedaquiline
rifampicin
mtrB 3626009 p.Ala202Lys missense_variant 0.18 bedaquiline
rifampicin
mtrB 3626029 c.585A>G synonymous_variant 0.16 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626867 c.-254G>T upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626888 p.Leu154Phe missense_variant 0.16 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3626939 p.Glu137Asp missense_variant 0.17 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627059 c.-446G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627080 c.270T>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
rpoA 3877679 p.Ala277Thr missense_variant 0.16 rifampicin
rpoA 3877704 c.804G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877737 c.771G>C synonymous_variant 0.22 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.17 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.18 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877965 c.543C>G synonymous_variant 0.17 rifampicin
rpoA 3877968 c.540C>G synonymous_variant 0.17 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.19 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.22 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.24 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.24 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.25 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>G synonymous_variant 0.25 rifampicin
rpoA 3878052 c.456C>T synonymous_variant 0.28 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.28 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.28 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.28 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.27 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.28 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.28 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.29 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.3 rifampicin
rpoA 3878143 p.Gly122Ala missense_variant 0.3 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.32 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.31 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.3 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.29 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.32 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.32 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.31 rifampicin
rpoA 3878307 c.201C>G synonymous_variant 0.31 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.33 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.33 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.33 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878415 c.93C>T synonymous_variant 0.35 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.33 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.32 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.33 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.33 rifampicin
rpoA 3878458 p.Asn17Thr missense_variant 0.32 rifampicin
rpoA 3878468 p.Leu14Val missense_variant 0.26 rifampicin Uncertain significance
rpoA 3878472 p.Asp12Glu missense_variant 0.25 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.23 rifampicin
rpoA 3878701 c.-194C>G upstream_gene_variant 0.17 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.26 rifampicin
rpoA 3878734 c.-229_-227delATCinsGT upstream_gene_variant 0.25 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.27 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878749 c.-242G>C upstream_gene_variant 0.27 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.26 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.25 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.26 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.22 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.23 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.23 rifampicin
rpoA 3878848 c.-341C>G upstream_gene_variant 0.25 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.24 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878894 c.-387A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878917 c.-410G>C upstream_gene_variant 0.17 rifampicin
rpoA 3878923 c.-417_-416delGCinsCG upstream_gene_variant 0.18 rifampicin
rpoA 3878929 c.-422G>C upstream_gene_variant 0.18 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.2 rifampicin
rpoA 3878947 c.-440G>A upstream_gene_variant 0.21 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878995 c.-488A>G upstream_gene_variant 0.2 rifampicin
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.18 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.21 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.23 rifampicin
rpoA 3879034 c.-527G>A upstream_gene_variant 0.25 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.25 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.28 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.25 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.21 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.18 rifampicin
rpoA 3879130 c.-623A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.19 rifampicin
ddn 3986762 c.-82G>A upstream_gene_variant 1.0 delamanid
pretomanid
clpC1 4038842 c.1863G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.2 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038992 c.1713C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039283 c.1422C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.19 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039328 c.1377A>C synonymous_variant 0.22 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.23 pyrazinamide
clpC1 4039343 c.1362G>A synonymous_variant 0.24 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039370 c.1335G>A synonymous_variant 0.25 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039403 c.1302G>A synonymous_variant 0.21 pyrazinamide
clpC1 4039406 c.1299G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039466 c.1239T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039789 p.Ser306Thr missense_variant 0.16 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.17 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.19 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.18 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.23 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040147 c.558A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.24 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040180 c.525C>T synonymous_variant 0.25 pyrazinamide
clpC1 4040200 c.505T>C synonymous_variant 0.23 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.21 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.21 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040258 c.447G>A synonymous_variant 0.19 pyrazinamide
clpC1 4040324 c.381G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040995 c.-291C>T upstream_gene_variant 1.0 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4139183 c.572dupG frameshift_variant 0.92 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240897 c.1035C>A synonymous_variant 0.15 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.17 ethambutol
embC 4240960 c.1098G>C synonymous_variant 0.18 ethambutol
embC 4240966 c.1104G>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4240975 c.1113C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4240981 c.1119G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4240983 p.Ser374Asn missense_variant 0.18 ethambutol
embC 4240990 c.1128A>G synonymous_variant 0.18 ethambutol
embC 4241005 c.1143G>C synonymous_variant 0.18 ethambutol
embC 4241008 c.1146G>C synonymous_variant 0.18 ethambutol
embC 4241011 c.1149C>A synonymous_variant 0.18 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.18 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.19 ethambutol
embC 4241024 p.Val388Thr missense_variant 0.19 ethambutol
embC 4241030 c.1168C>T synonymous_variant 0.18 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.19 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.19 ethambutol
embC 4241059 c.1197G>A synonymous_variant 0.2 ethambutol
embC 4241086 c.1224G>C synonymous_variant 0.16 ethambutol
embC 4241665 c.1803G>C synonymous_variant 0.2 ethambutol
embC 4241671 c.1809T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241683 c.1821G>C synonymous_variant 0.18 ethambutol
embC 4241843 p.Leu661Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 0.93 ethambutol Not assoc w R
embA 4244379 p.Pro383Ser missense_variant 0.92 ethambutol Not assoc w R
embA 4244802 p.Leu524Met missense_variant 0.2 ethambutol
embA 4244805 p.Leu525Met missense_variant 0.2 ethambutol Uncertain significance
embA 4244808 c.1576_1578delTTCinsCG frameshift_variant&missense_variant 0.2 ethambutol Uncertain significance
embA 4244823 p.Val531Met missense_variant 0.24 ethambutol
embA 4244829 c.1597_1599delTTCinsGG frameshift_variant&missense_variant 0.29 ethambutol Uncertain significance
embA 4244850 p.Arg540Gly missense_variant 0.3 ethambutol
embA 4244856 c.1624_1626delGCGinsCC frameshift_variant&missense_variant 0.29 ethambutol Uncertain significance
embA 4244879 c.1647C>G synonymous_variant 0.27 ethambutol
embA 4244885 c.1653A>G synonymous_variant 0.27 ethambutol
embA 4244886 c.1654C>T synonymous_variant 0.24 ethambutol
embA 4244897 c.1665T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embA 4244900 c.1668G>C synonymous_variant 0.2 ethambutol
embA 4244903 c.1671G>C synonymous_variant 0.2 ethambutol
embA 4244905 p.Val558Gly missense_variant 0.2 ethambutol
embA 4244909 c.1677C>A synonymous_variant 0.18 ethambutol
embA 4244919 c.1687_1689delCTCinsTG frameshift_variant&missense_variant 0.18 ethambutol Uncertain significance
embA 4245509 c.2277A>G synonymous_variant 0.18 ethambutol
embA 4245512 c.2280G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4245518 c.-996A>G upstream_gene_variant 0.17 ethambutol
embB 4245560 c.-954C>G upstream_gene_variant 0.17 ethambutol
embA 4245567 p.Glu779Leu missense_variant 0.17 ethambutol
embA 4245594 p.Ser788Thr missense_variant 0.15 ethambutol
embB 4245626 c.-888G>C upstream_gene_variant 0.17 ethambutol
embB 4245653 c.-861C>T upstream_gene_variant 0.16 ethambutol
embB 4245671 c.-843C>A upstream_gene_variant 0.15 ethambutol
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 0.95 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269522 c.312C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326208 c.1266G>T synonymous_variant 0.15 ethionamide
ethA 4326220 c.1254C>A synonymous_variant 0.15 ethionamide
ethA 4326465 p.Ile337Val missense_variant 0.93 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338602 c.-81A>C upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4408034 p.Glu57Lys missense_variant 1.0 streptomycin Uncertain significance