TB-Profiler result

Run: ERR9787336
Summary

Run ID: ERR9787336

Sample name:

Date: 2024-04-15T07:21:11.389677

Number of reads: 2566844

Percentage reads mapped: 74.81

Median coverage: 114.0

Strain: lineage6.1.3

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage6.1.3 West-Africa 2 RD702 0.71
lineage6 West-Africa 2 RD702 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser428Cys Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Ser450Asn Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol embC p.Ala307Thr Uncertain significance Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761088 p.Ser428Cys missense_variant 0.12 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761154 p.Ser450Asn missense_variant 0.13 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
embC 4240781 p.Ala307Thr missense_variant 1.0 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6446 p.Ala403Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8493 p.Leu398Phe missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 1.0 isoniazid Not assoc w R
fgd1 491668 p.Lys296Glu missense_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 656054 p.Arg473* stop_gained 1.0 ethionamide Uncertain significance
Rv0565c 656432 p.Gly347Ser missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657686 c.-216C>G upstream_gene_variant 1.0 ethionamide
rpoB 760490 c.684C>G synonymous_variant 0.13 rifampicin
rpoB 760855 p.Thr350Ile missense_variant 0.98 rifampicin Uncertain significance
rpoB 760969 p.Ser388Leu missense_variant 0.95 rifampicin Not assoc w R
rpoB 761132 c.1326G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.14 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>G synonymous_variant 0.16 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761201 c.1395G>A synonymous_variant 0.15 rifampicin
rpoB 761204 c.1398C>A synonymous_variant 0.16 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.15 rifampicin
rpoB 761723 p.Glu639Asp missense_variant 1.0 rifampicin Not assoc w R
rpoB 762167 c.2361T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762170 c.2364C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762179 c.2373C>T synonymous_variant 0.13 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.12 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.13 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.13 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.16 rifampicin Uncertain significance
rpoB 762899 c.3093G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.21 rifampicin
rpoB 762989 c.3183G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762998 c.-372G>A upstream_gene_variant 0.2 rifampicin
rpoB 763004 c.3198G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763053 c.3247T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.17 rifampicin
rpoC 763079 c.-291C>G upstream_gene_variant 0.17 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.17 rifampicin
rpoC 763124 c.-246C>T upstream_gene_variant 0.16 rifampicin
rpoC 763139 c.-231C>T upstream_gene_variant 0.12 rifampicin
rpoC 763142 c.-228C>G upstream_gene_variant 0.12 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763558 c.189C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.13 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.14 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.14 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.14 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.14 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.16 rifampicin
rpoC 764510 c.1141C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.14 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764572 c.1203G>C synonymous_variant 0.13 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764577 p.Ser403Cys missense_variant 0.12 rifampicin Uncertain significance
rpoC 764593 c.1224C>T synonymous_variant 0.13 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.15 rifampicin
rpoC 764605 c.1236G>T synonymous_variant 0.15 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764641 c.1272C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.14 rifampicin
rpoC 764662 c.1293G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764677 c.1308C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764680 c.1311G>A synonymous_variant 0.14 rifampicin
rpoC 764731 c.1362G>C synonymous_variant 0.16 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.17 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>G synonymous_variant 0.15 rifampicin
rpoC 764809 c.1440C>G synonymous_variant 0.15 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.15 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765820 c.2451G>C synonymous_variant 0.13 rifampicin
rpoC 765835 c.2466C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.17 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.16 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765904 c.2535C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765907 c.2538G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766231 c.2862T>C synonymous_variant 0.99 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777761 c.720G>A synonymous_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781754 c.195G>C synonymous_variant 0.14 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.13 streptomycin
rplC 800232 c.-577G>T upstream_gene_variant 0.99 linezolid
Rv1129c 1254221 p.Gln105Pro missense_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 0.99 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
Rv1258c 1406685 p.Val219Ala missense_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
embR 1416633 p.Leu239Val missense_variant 1.0 ethambutol Uncertain significance
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
atpE 1461251 c.207G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471978 n.133C>T non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471979 n.134T>C non_coding_transcript_exon_variant 0.13 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.13 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472023 n.178G>C non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>C non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472032 n.187G>A non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472043 n.198T>G non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472057 n.212C>A non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472062 n.217G>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472068 n.223T>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472070 n.225G>A non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472225 n.380C>G non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472285 n.440A>G non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472286 n.441C>A non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472288 n.443A>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>C non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsAA non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472326 n.481T>A non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472330 n.485G>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472416 n.571C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472425 n.580T>C non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472435 n.590T>C non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472437 n.592T>A non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472451 n.606C>G non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472467 n.622G>T non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472486 n.641A>G non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472497 n.652G>T non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472580 n.735C>A non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472844 n.999C>A non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472845 n.1000G>A non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472855 n.1011_1012insGT non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472861 n.1016_1018delGTTinsC non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.3 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.44 streptomycin Not assoc w R
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473822 n.165A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230delTinsCA non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474288 n.631_634delCCTTinsGTGCCAC non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474294 n.638_646delCTCTCCGGA non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474306 n.649A>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474310 n.655dupG non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474414 n.757C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474415 n.758C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474416 n.761_784delCACGCGCATACGCGCGTGTGAATA non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474444 n.787G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474664 n.1007G>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474666 n.1009T>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474670 n.1013C>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474679 n.1022G>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474684 n.1027T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474687 n.1030C>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474710 n.1053T>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474711 n.1054G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474716 n.1059_1060delAAinsGAG non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474825 n.1168G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474837 n.1180A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475555 n.1898T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475627 n.1970G>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475735 n.2078T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475760 n.2103C>G non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475762 n.2105G>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475765 n.2108A>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475769 n.2113_2114insCG non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475791 n.2134A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475892 n.2235A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476058 n.2401T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.35 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.34 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.35 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.36 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.39 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.17 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
inhA 1674434 p.Val78Ala missense_variant 1.0 ethionamide Uncertain significance
isoniazid Not assoc w R
rpsA 1833799 c.258C>G synonymous_variant 0.13 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.13 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833859 c.318C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833871 c.330G>A synonymous_variant 0.14 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.13 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833919 c.378C>T synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
rpsA 1833920 p.Lys127Arg missense_variant 0.14 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.15 pyrazinamide
rpsA 1833931 c.390C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.18 pyrazinamide
rpsA 1833964 c.423C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1833970 c.429G>T synonymous_variant 0.16 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.18 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834151 c.610_612delAATinsCC frameshift_variant&missense_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834154 c.613_615delAACinsCG frameshift_variant&missense_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834157 c.616T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.14 pyrazinamide
rpsA 1834167 c.628_629delAC frameshift_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834172 c.631_632insGG frameshift_variant 0.14 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834298 p.Gln253Glu missense_variant 0.17 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.17 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834307 p.Asp256Asn missense_variant 0.17 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.19 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.19 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834369 c.828C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834375 c.834G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.22 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.2 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.21 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834528 c.987T>G synonymous_variant 0.16 pyrazinamide
rpsA 1834540 c.999G>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
rpsA 1834543 c.1002C>G synonymous_variant 0.13 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.13 pyrazinamide
rpsA 1834557 p.Ala339Val missense_variant 0.14 pyrazinamide
rpsA 1834561 c.1020C>G synonymous_variant 0.13 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2063121 c.1608A>T synonymous_variant 1.0 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
Rv2477c 2783554 c.489C>G synonymous_variant 0.12 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.12 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.12 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3236c 3612143 p.Arg325His missense_variant 1.0 pyrazinamide Uncertain significance
lpqB 3624350 c.561G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
fbiB 3642647 c.1113C>G synonymous_variant 0.99 clofazimine
pretomanid
delamanid
alr 3840780 p.Arg214Gln missense_variant 1.0 cycloserine
rpoA 3877743 c.765T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3877749 c.759C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877752 p.Asp252Glu missense_variant 0.15 rifampicin
rpoA 3877764 p.Ala248Gly missense_variant 0.14 rifampicin
rpoA 3877770 c.738A>C synonymous_variant 0.14 rifampicin
rpoA 3877773 c.735G>C synonymous_variant 0.14 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877797 c.711G>C synonymous_variant 0.15 rifampicin
rpoA 3877800 c.708G>C synonymous_variant 0.15 rifampicin
rpoA 3877803 c.705G>C synonymous_variant 0.15 rifampicin
rpoA 3877824 c.684G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877833 c.675C>G synonymous_variant 0.16 rifampicin
rpoA 3877836 c.672A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>T synonymous_variant 0.16 rifampicin
rpoA 3877842 c.666A>C synonymous_variant 0.16 rifampicin
rpoA 3877856 c.652T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877866 c.642G>C synonymous_variant 0.14 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.14 rifampicin
rpoA 3877881 c.627G>C synonymous_variant 0.14 rifampicin
rpoA 3877884 c.624G>C synonymous_variant 0.13 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.13 rifampicin
rpoA 3877898 p.Pro204Ala missense_variant 0.14 rifampicin
rpoA 3877905 c.603A>C synonymous_variant 0.13 rifampicin
rpoA 3877908 c.600T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.12 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.13 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038896 c.1809C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038899 c.1806C>G synonymous_variant 0.15 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.14 pyrazinamide
clpC1 4038911 c.1794G>C synonymous_variant 0.13 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.14 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.14 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.14 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039004 c.1701C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039046 c.1659C>T synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4039079 c.1626C>G synonymous_variant 0.12 pyrazinamide Not assoc w R - Interim
clpC1 4039103 c.1602T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.13 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.13 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.13 pyrazinamide Uncertain significance
clpC1 4039448 c.1257A>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>C synonymous_variant 0.13 pyrazinamide
clpC1 4039463 c.1242C>G synonymous_variant 0.12 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.23 pyrazinamide Uncertain significance
clpC1 4039571 c.1134G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.24 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039628 c.1077C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039634 c.1069_1071delGAGinsAC frameshift_variant&missense_variant 0.23 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039694 c.1011G>T synonymous_variant 0.15 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039913 c.792C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039919 c.786C>T synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039925 c.780C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.13 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4139183 c.572dupG frameshift_variant 0.8 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4241843 p.Leu661Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244379 p.Pro383Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269522 c.312C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4326465 p.Ile337Val missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4408034 p.Glu57Lys missense_variant 1.0 streptomycin Uncertain significance