TB-Profiler result

Run: ERR9992879
Summary

Run ID: ERR9992879

Sample name:

Date: 2024-04-16T07:45:52.835911

Number of reads: 828403

Percentage reads mapped: 21.21

Median coverage: 24.0

Strain: lineage4.3.3

Spoligotype:

Drug-resistance: XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 1.0
lineage4 Euro-American None 1.0
lineage4.3.3 Euro-American (LAM) RD115 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Asp435Val Assoc w R
p.Ser441Ala Assoc w R - Interim
c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid inhA c.-770T>A Assoc w R - Interim Alias fabG1_c.-8T>A. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Val Assoc w R
pyrazinamide pncA p.Gly132Ala Assoc w R
streptomycin gid c.160_290del Assoc w R
fluoroquinolones
moxifloxacin gyrA p.Asp94Asn Assoc w R High-level resistance
ofloxacin
levofloxacin gyrA p.Asp94Asn Assoc w R
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide inhA c.-770T>A Assoc w R - Interim Alias fabG1_c.-8T>A
ethA c.-11A>G Uncertain significance Mutation from literature
clofazimine mmpR5 c.198dupG Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
para-aminosalicylic_acid
delamanid
bedaquiline mmpR5 c.198dupG Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7581 p.Asp94Asn missense_variant 1.0 levofloxacin Assoc w R
moxifloxacin Assoc w R High-level resistance
rpoB 761110 p.Asp435Val missense_variant 0.33 rifampicin Assoc w R
rpoB 761127 p.Ser441Ala missense_variant 0.6 rifampicin Assoc w R - Interim
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.62 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
mmpR5 779181 c.198dupG frameshift_variant 0.96 clofazimine Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
bedaquiline Assoc w R Can only confer resistance if genetically linked to a functional MmpL5
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.84 kanamycin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
amikacin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.72 capreomycin Assoc w R
kanamycin Assoc w R
amikacin Assoc w R
inhA 1673432 c.-770T>A upstream_gene_variant 1.0 ethionamide Assoc w R - Interim Alias fabG1_c.-8T>A
isoniazid Assoc w R - Interim Alias fabG1_c.-8T>A. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
pncA 2288847 p.Gly132Ala missense_variant 1.0 pyrazinamide Assoc w R
embB 4247429 p.Met306Val missense_variant 1.0 ethambutol Assoc w R
ethA 4327484 c.-11A>G upstream_gene_variant 1.0 ethionamide Uncertain significance Mutation from literature
gid 4407912 c.160_290del frameshift_variant 1.0 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8040 p.Gly247Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rpoB 760982 c.1176G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.32 rifampicin
rpoB 760997 c.1191G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761013 c.1207_1209delGTGinsAC frameshift_variant&missense_variant 0.56 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761046 c.1240_1242delATCinsGG frameshift_variant&missense_variant 0.62 rifampicin
rpoB 761051 c.1245G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761087 c.1281C>G synonymous_variant 0.68 rifampicin
rpoB 761088 c.1282_1284delAGCinsTCG synonymous_variant 0.68 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.65 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.68 rifampicin
rpoB 761126 c.1320G>C synonymous_variant 0.6 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>G synonymous_variant 0.4 rifampicin
rpoB 761189 c.1383T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761192 c.1386C>G synonymous_variant 0.41 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761196 c.1390_1392delCTGinsGC frameshift_variant&missense_variant 0.42 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.4 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761243 c.1437G>C synonymous_variant 0.33 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762831 c.3025_3026delAGinsTC synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762849 p.Tyr1015Ala missense_variant 0.38 rifampicin
rpoC 762854 c.-516G>C upstream_gene_variant 0.42 rifampicin
rpoB 762858 p.Thr1018Ser missense_variant 0.52 rifampicin
rpoB 762863 c.3057T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.53 rifampicin Uncertain significance
rpoB 762899 c.3093G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 762980 c.-390T>C upstream_gene_variant 0.58 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.56 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763005 p.Cys1067Val missense_variant 0.46 rifampicin
rpoB 763014 c.3208_3210delATGinsCT frameshift_variant&missense_variant 0.41 rifampicin
rpoB 763017 p.Gln1071Glu missense_variant 0.43 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.38 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763038 c.3232_3234delACCinsGG frameshift_variant&missense_variant 0.34 rifampicin
rpoC 763052 c.-318G>C upstream_gene_variant 0.34 rifampicin
rpoB 763053 c.3247_3249delTTGinsCC frameshift_variant&missense_variant 0.33 rifampicin
rpoC 763058 c.-312C>G upstream_gene_variant 0.35 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763075 p.Thr1090Ile missense_variant 0.4 rifampicin
rpoC 763082 c.-288C>A upstream_gene_variant 0.43 rifampicin
rpoB 763094 c.3288G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763511 p.Cys48Gly missense_variant 0.41 rifampicin
rpoC 763517 p.Lys50Gln missense_variant 0.41 rifampicin
rpoC 763528 c.159G>T synonymous_variant 0.47 rifampicin
rpoC 763532 c.163_165delACTinsTC frameshift_variant&missense_variant 0.47 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763550 p.Tyr61Ala missense_variant 0.58 rifampicin
rpoC 763570 c.201G>T synonymous_variant 0.63 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 763589 p.Ile74Val missense_variant 0.73 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 763619 p.Arg84Lys missense_variant 0.74 rifampicin
rpoC 763622 p.Ala85Ser missense_variant 0.75 rifampicin Uncertain significance
rpoC 763625 p.Lys86Ser missense_variant 0.76 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.77 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.68 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.68 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.64 rifampicin
rpoC 763727 p.Leu120Met missense_variant 0.62 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.54 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.46 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.44 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.43 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764377 c.1008C>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.57 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764398 c.1029G>A synonymous_variant 0.62 rifampicin
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.58 rifampicin
rpoC 764410 c.1041G>C synonymous_variant 0.57 rifampicin
rpoC 764428 c.1059G>T synonymous_variant 0.55 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764432 p.Lys355Arg missense_variant 0.54 rifampicin
rpoC 764435 c.1066A>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.52 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.51 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 0.53 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.56 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.57 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.56 rifampicin
rpoC 764533 c.1164C>T synonymous_variant 0.56 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>G synonymous_variant 0.46 rifampicin
rpoC 764545 c.1176C>G synonymous_variant 0.48 rifampicin
rpoC 764548 c.1179G>C synonymous_variant 0.48 rifampicin
rpoC 764549 p.Pro394Thr missense_variant 0.48 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764561 p.Pro398Ala missense_variant 0.49 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764572 c.1203G>C synonymous_variant 0.49 rifampicin
rpoC 764575 c.1206T>C synonymous_variant 0.5 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.5 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.51 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.55 rifampicin
rpoC 764587 c.1218C>G synonymous_variant 0.58 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.71 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>G synonymous_variant 0.56 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764660 c.1291_1293delGTGinsAC frameshift_variant&missense_variant 0.56 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764677 c.1308C>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 764706 p.Leu446Gln missense_variant 0.56 rifampicin Uncertain significance
rpoC 764716 c.1347G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764722 c.1353G>C synonymous_variant 0.56 rifampicin
rpoC 764737 c.1368G>C synonymous_variant 0.46 rifampicin
rpoC 764740 p.Met457Ile missense_variant 0.46 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781794 c.235_237delATGinsCC frameshift_variant&missense_variant 0.19 streptomycin Uncertain significance
rpsL 781802 c.243G>C synonymous_variant 0.19 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.2 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.2 streptomycin
rpsL 781811 c.252C>A synonymous_variant 0.2 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.19 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.19 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.2 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.19 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.19 streptomycin
rpsL 781851 c.292_294delATCinsGT frameshift_variant&missense_variant 0.18 streptomycin Uncertain significance
rpsL 781859 c.300T>C synonymous_variant 0.19 streptomycin Not assoc w R - Interim
rpsL 781860 c.301_303delTCGinsGC frameshift_variant&missense_variant 0.19 streptomycin Uncertain significance
rpsL 781868 c.309T>C synonymous_variant 0.2 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.19 streptomycin
rpsL 781876 p.Gly106Ala missense_variant 0.19 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.2 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.2 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.2 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.19 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.19 streptomycin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472256 n.411T>C non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472507 n.662C>T non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>A non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472606 n.761C>G non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472623 n.778A>C non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472645 n.800G>C non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>A non_coding_transcript_exon_variant 0.79 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472666 n.821G>T non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472694 n.849C>A non_coding_transcript_exon_variant 0.75 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>T non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472991 n.1146G>A non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472993 n.1148G>T non_coding_transcript_exon_variant 0.8 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473097 n.1252G>A non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473134 n.1289T>C non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473147 n.1302G>A non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
rrs 1473164 n.1319C>T non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473269 n.1424C>T non_coding_transcript_exon_variant 0.84 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.82 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.78 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.81 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473320 n.1475G>A non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473324 n.1479G>A non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474601 n.944C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1474723 n.1066G>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474770 n.1113G>A non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.62 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.62 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474790 n.1133C>T non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474800 n.1143T>C non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475065 n.1408G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475068 n.1411A>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475078 n.1421T>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475084 n.1427G>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475108 n.1451C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475111 n.1454G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475119 n.1462C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475692 n.2035G>C non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101_2102delACinsG non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475768 n.2111_2112delGTinsC non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475963 n.2306G>T non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.75 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid Uncertain significance
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476034 n.2377C>T non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1476046 n.2389G>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1476047 n.2390G>C non_coding_transcript_exon_variant 0.58 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 0.39 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476079 n.2422G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476080 n.2423T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476081 n.2424A>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476082 n.2425T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476087 n.2430C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476104 n.2448delG non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.63 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.72 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476337 n.2680C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.89 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.88 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.85 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476544 n.2887T>A non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1476566 n.2909A>T non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833636 p.Tyr32Phe missense_variant 0.3 pyrazinamide
rpsA 1833646 c.105T>C synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1833649 c.108C>A synonymous_variant 0.32 pyrazinamide
rpsA 1833653 p.Ile38Leu missense_variant 0.32 pyrazinamide
rpsA 1833656 p.Val39Ile missense_variant 0.37 pyrazinamide
rpsA 1833668 p.Ile43Val missense_variant 0.48 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.49 pyrazinamide
rpsA 1833677 c.136_138delGTGinsAC frameshift_variant&missense_variant 0.48 pyrazinamide Uncertain significance
rpsA 1833685 c.144G>C synonymous_variant 0.51 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.5 pyrazinamide
rpsA 1833704 p.Ile55Val missense_variant 0.53 pyrazinamide Uncertain significance
rpsA 1833709 c.168C>T synonymous_variant 0.57 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.62 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.65 pyrazinamide
rpsA 1833734 c.193_195delGCCinsTG frameshift_variant&missense_variant 0.65 pyrazinamide Uncertain significance
rpsA 1833742 c.201A>G synonymous_variant 0.66 pyrazinamide
rpsA 1833745 c.204G>T synonymous_variant 0.66 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.65 pyrazinamide
rpsA 1833781 c.240T>C synonymous_variant 0.64 pyrazinamide
rpsA 1833782 p.Ser81Lys missense_variant 0.62 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.63 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.63 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.57 pyrazinamide
rpsA 1833814 c.273C>T synonymous_variant 0.53 pyrazinamide
rpsA 1833815 p.Thr92Gln missense_variant 0.53 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.51 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.5 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.53 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.51 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.46 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.42 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.54 pyrazinamide
rpsA 1833959 p.Leu140Val missense_variant 0.54 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.54 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.55 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.57 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.58 pyrazinamide
rpsA 1833998 c.457_459delGTGinsAC frameshift_variant&missense_variant 0.58 pyrazinamide Uncertain significance
rpsA 1834004 p.Met155Leu missense_variant 0.57 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.58 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.57 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.58 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.58 pyrazinamide
rpsA 1834025 p.Gln162Thr missense_variant 0.58 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.56 pyrazinamide
rpsA 1834034 p.Ile165Leu missense_variant 0.56 pyrazinamide Uncertain significance
rpsA 1834040 p.Lys167Gln missense_variant 0.56 pyrazinamide
rpsA 1834061 p.Ile174Leu missense_variant 0.62 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834090 c.549G>C synonymous_variant 0.42 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223051 p.Glu38Asp missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518919 p.Gly269Ser missense_variant 1.0 isoniazid
Rv2752c 3065824 p.Pro123Leu missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Uncertain significance
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R - Interim
thyA 3073868 p.Thr202Ala missense_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
whiB7 3568883 c.-205_-204insA upstream_gene_variant 1.0 streptomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
clpC1 4038287 c.2418C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
clpC1 4039850 c.855T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039853 c.850_852delCTGinsGC frameshift_variant&missense_variant 0.22 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039871 c.834C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039875 p.Asn277Arg missense_variant 0.24 pyrazinamide
clpC1 4039887 p.Leu273Thr missense_variant 0.27 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.48 pyrazinamide
clpC1 4039929 c.775_776delAGinsTC synonymous_variant 0.62 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039937 c.766_768delGTGinsAC frameshift_variant&missense_variant 0.63 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.63 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.6 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.58 pyrazinamide
clpC1 4039960 p.Thr249Ser missense_variant 0.54 pyrazinamide
clpC1 4039966 p.Leu247Val missense_variant 0.55 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.58 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.53 pyrazinamide
clpC1 4039998 p.Gly236Asn missense_variant 0.53 pyrazinamide
clpC1 4040000 c.703_705delCACinsAG frameshift_variant&missense_variant 0.53 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.57 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.58 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.58 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.6 pyrazinamide
clpC1 4040324 c.381G>C synonymous_variant 0.43 pyrazinamide
clpC1 4040333 c.372G>C synonymous_variant 0.44 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.43 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.4 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.39 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.38 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.36 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R