TB-Profiler result

Run: SRR25827687
Summary

Run ID: SRR25827687

Sample name:

Date: 2024-04-14T20:34:20.950987

Number of reads: 1904060

Percentage reads mapped: 39.52

Median coverage: 58.0

Strain: lineage1.1.2

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.1.2 Indo-Oceanic RD239 0.94
lineage1.1 Indo-Oceanic RD239 0.99
La1.2.BCG M.bovis None 0.12
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
p.Ile21Thr Uncertain significance Mutation from literature
ethambutol embB p.Tyr334His Uncertain significance Mutation from literature
pyrazinamide
streptomycin rpsL p.Lys88Arg Assoc w R
rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
p.Ile21Thr Uncertain significance Mutation from literature
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.604_606delTCGinsGC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin Assoc w R
rpsL 781822 p.Lys88Arg missense_variant 0.69 streptomycin Assoc w R
fbiC 1303534 c.604_606delTCGinsGC frameshift_variant&missense_variant 0.17 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.32 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.19 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance Mutation from literature
inhA 1673425 c.-777C>T upstream_gene_variant 1.0 ethionamide Assoc w R Alias fabG1_c.-15C>T
isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
inhA 1674263 p.Ile21Thr missense_variant 1.0 ethionamide Uncertain significance Mutation from literature
isoniazid Uncertain significance Mutation from literature
embB 4247513 p.Tyr334His missense_variant 0.69 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 795 c.795A>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.19 isoniazid Uncertain significance
dnaA 813 c.813C>T synonymous_variant 0.21 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.21 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.2 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.21 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.21 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.22 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.22 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.21 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.22 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.22 isoniazid
dnaA 882 c.882C>T synonymous_variant 0.21 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.21 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.21 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.22 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.2 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1041 c.1041G>A synonymous_variant 0.17 isoniazid
dnaA 1047 c.1047A>G synonymous_variant 0.19 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.24 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.25 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.25 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.25 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.25 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.25 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.25 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.26 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.26 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.25 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.25 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.24 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.21 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.19 isoniazid
gyrB 6112 p.Met291Ile missense_variant 0.91 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6124 c.885C>T synonymous_variant 0.91 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 6751 c.-551G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.15 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.15 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8111 c.810G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8189 c.888G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8198 c.897T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8452 p.Ala384Val missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13298 p.Ile87Met missense_variant 1.0 isoniazid Not assoc w R
fgd1 491283 p.Asp167Glu missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491661 c.879C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491673 c.891A>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491676 c.894T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491679 c.897A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491687 p.Thr302Lys missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491697 c.915G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491709 c.927A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491712 c.930T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
ccsA 619507 c.-384A>G upstream_gene_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620385 c.495G>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620388 c.498A>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620389 c.499C>T synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.19 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620424 c.534G>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620433 c.543C>G synonymous_variant 0.2 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620631 c.741T>G synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620649 c.759A>G synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620659 c.769_771delCGCinsAG frameshift_variant&missense_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620664 c.774C>T synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.31 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAA frameshift_variant&missense_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620745 c.855G>C synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620763 c.873G>A synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620769 c.879C>G synonymous_variant 0.28 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620778 c.888T>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620790 c.900C>T synonymous_variant 0.16 capreomycin
amikacin
kanamycin
Rv0565c 656243 p.Leu410Met missense_variant 0.16 ethionamide
Rv0565c 656244 c.1227A>C synonymous_variant 0.16 ethionamide
Rv0565c 656289 c.1182C>G synonymous_variant 0.21 ethionamide
Rv0565c 656298 c.1173G>C synonymous_variant 0.22 ethionamide
Rv0565c 656304 c.1167T>C synonymous_variant 0.2 ethionamide
Rv0565c 656924 p.Ile183Val missense_variant 0.3 ethionamide
Rv0565c 656936 p.Thr179Ala missense_variant 0.3 ethionamide
Rv0565c 656940 c.531C>T synonymous_variant 0.31 ethionamide Not assoc w R - Interim
Rv0565c 656946 c.525T>C synonymous_variant 0.31 ethionamide
Rv0565c 656952 c.519A>C synonymous_variant 0.31 ethionamide Not assoc w R - Interim
Rv0565c 656967 c.504T>C synonymous_variant 0.3 ethionamide
Rv0565c 656973 c.498A>G synonymous_variant 0.3 ethionamide
Rv0565c 656978 p.Ala165Thr missense_variant 0.3 ethionamide
Rv0565c 656982 p.Gly163Gln missense_variant 0.29 ethionamide
Rv0565c 656985 c.486T>C synonymous_variant 0.29 ethionamide
Rv0565c 656990 p.Lys161Glu missense_variant 0.28 ethionamide
Rv0565c 657000 p.Gly157Pro missense_variant 0.28 ethionamide
Rv0565c 657027 c.444T>C synonymous_variant 0.28 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
Rv0565c 657592 c.-122A>C upstream_gene_variant 0.17 ethionamide
Rv0565c 657600 c.-132_-131delCA upstream_gene_variant 0.17 ethionamide
Rv0565c 657606 c.-136T>G upstream_gene_variant 0.17 ethionamide
Rv0565c 657607 c.-138_-137insCA upstream_gene_variant 0.17 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.18 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.18 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.18 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.2 ethionamide
hadA 731693 c.-237C>A upstream_gene_variant 0.17 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.18 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.22 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.21 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.21 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.25 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.29 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.27 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.24 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.21 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.21 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.2 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.2 isoniazid
hadA 731840 c.-90G>C upstream_gene_variant 0.18 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.18 isoniazid
hadA 731849 c.-81C>T upstream_gene_variant 0.2 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.19 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.23 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.24 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.29 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.32 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.35 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.43 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.42 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.42 isoniazid
nusG 734078 c.-176C>G upstream_gene_variant 0.18 rifampicin Uncertain significance
nusG 734093 c.-161A>C upstream_gene_variant 0.18 rifampicin
nusG 734102 c.-152G>C upstream_gene_variant 0.17 rifampicin
nusG 734111 c.-143A>G upstream_gene_variant 0.19 rifampicin
nusG 734114 c.-140A>G upstream_gene_variant 0.18 rifampicin
nusG 734116 c.-138T>C upstream_gene_variant 0.82 rifampicin Not assoc w R
nusG 734120 c.-134T>C upstream_gene_variant 0.19 rifampicin Uncertain significance
nusG 734123 c.-131C>G upstream_gene_variant 0.19 rifampicin
nusG 734129 c.-125G>C upstream_gene_variant 0.19 rifampicin
nusG 734132 c.-122G>C upstream_gene_variant 0.19 rifampicin
nusG 734135 c.-119G>C upstream_gene_variant 0.18 rifampicin
nusG 734144 c.-110G>C upstream_gene_variant 0.19 rifampicin
nusG 734147 c.-107T>C upstream_gene_variant 0.2 rifampicin
nusG 734173 c.-81C>G upstream_gene_variant 0.24 rifampicin
nusG 734175 c.-79_-77delGGTinsCTG upstream_gene_variant 0.25 rifampicin
nusG 734180 c.-74T>G upstream_gene_variant 0.23 rifampicin Uncertain significance
nusG 734183 c.-71C>T upstream_gene_variant 0.26 rifampicin
nusG 734186 c.-68G>C upstream_gene_variant 0.26 rifampicin Uncertain significance
nusG 734205 c.-49A>C upstream_gene_variant 0.2 rifampicin
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.23 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.26 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.27 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.33 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.36 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.37 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.37 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
nusG 734532 c.279A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.31 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.3 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.28 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.26 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.26 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.25 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.24 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.23 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.22 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.21 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.21 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.19 rifampicin
nusG 734658 c.405A>G synonymous_variant 0.17 rifampicin Not assoc w R
nusG 734661 c.408A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734703 c.450T>C synonymous_variant 0.21 rifampicin
rpoB 759546 c.-261A>G upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoB 760283 c.477G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.39 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.38 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.45 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.46 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.52 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.48 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.48 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.43 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.4 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760490 c.684C>T synonymous_variant 0.85 rifampicin Not assoc w R
rpoB 760925 c.1119T>C synonymous_variant 0.22 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.23 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.23 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.32 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.31 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.25 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.26 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.43 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.43 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.41 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.39 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.36 rifampicin
rpoB 761373 p.Val523His missense_variant 0.36 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.36 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.33 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.29 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.28 rifampicin
rpoB 761439 c.1633_1635delGACinsAG frameshift_variant&missense_variant 0.28 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.29 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.3 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.29 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.28 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.31 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.29 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.3 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.3 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.3 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.19 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.21 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.33 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.36 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.35 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.34 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.34 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.38 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.35 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.33 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.33 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.33 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.33 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.36 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.37 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.39 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.36 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.32 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.26 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.26 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.27 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.3 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.26 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.27 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.28 rifampicin
rpoC 762581 c.-789T>C upstream_gene_variant 0.16 rifampicin
rpoC 762758 c.-612G>C upstream_gene_variant 0.17 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.26 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.26 rifampicin Uncertain significance
rpoC 762794 c.-576C>G upstream_gene_variant 0.28 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.29 rifampicin Uncertain significance
rpoB 762810 c.3004_3006delGCCinsTG frameshift_variant&missense_variant 0.3 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.3 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762926 c.3120C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.38 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.38 rifampicin
rpoC 763025 c.-345C>T upstream_gene_variant 0.37 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.62 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.3 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.33 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.32 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.33 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.32 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCG upstream_gene_variant 0.33 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.31 rifampicin
rpoB 763227 c.3421C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763238 c.3432T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.29 rifampicin
rpoC 763256 c.-114G>A upstream_gene_variant 0.28 rifampicin
rpoB 763268 c.3462C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.25 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.3 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.31 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.33 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.35 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.35 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.34 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.35 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.39 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.36 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.33 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.3 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.24 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.2 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.17 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.17 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.17 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.82 rifampicin Not assoc w R
rpoC 763886 c.517_519delCGGinsAC frameshift_variant&missense_variant 0.82 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.21 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.21 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.22 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.23 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.27 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.31 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764102 p.Val245Ile missense_variant 0.31 rifampicin
rpoC 764112 p.Tyr248Phe missense_variant 0.32 rifampicin
rpoC 764116 c.747C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.36 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Ile missense_variant 0.41 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.4 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.44 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.43 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.41 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.39 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.39 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764353 c.984G>C synonymous_variant 0.23 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.42 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.43 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.48 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.49 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.44 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.43 rifampicin
rpoC 764827 c.1458G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.35 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.4 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.37 rifampicin Not assoc w R
rpoC 765019 c.1650A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.36 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765053 c.1684_1685delTCinsAG synonymous_variant 0.35 rifampicin
rpoC 765073 c.1704G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.3 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.26 rifampicin
rpoC 765171 p.Pro601Leu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765292 c.1923G>C synonymous_variant 0.16 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.18 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.19 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.24 rifampicin Uncertain significance
rpoC 765329 p.Ser654Gly missense_variant 0.24 rifampicin
rpoC 765346 c.1977C>G synonymous_variant 0.28 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.35 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.43 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.44 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765463 p.Asn698Lys missense_variant 0.62 rifampicin Uncertain significance
rpoC 765478 c.2109T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.47 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.46 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.41 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.4 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.42 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.43 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.4 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.4 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.4 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.4 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.42 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.41 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.39 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.4 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.39 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.41 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.42 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.25 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.17 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.21 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.24 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.26 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.34 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.32 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.34 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.36 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.36 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.31 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.31 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.29 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.21 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.16 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.17 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.23 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.32 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.32 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.3 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.31 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.48 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.47 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.41 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.32 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.22 rifampicin
rpoC 766972 c.3603G>C synonymous_variant 0.33 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.42 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.4 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.42 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.4 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.22 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.17 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776395 p.Phe696Leu missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Uncertain significance
mmpL5 777158 c.1323C>G synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 777164 c.1317C>G synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 777170 c.1311T>C synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.17 clofazimine
bedaquiline
mmpL5 777191 c.1290C>G synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 777206 c.1275A>G synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 777212 c.1267_1269delGCCinsAG frameshift_variant&missense_variant 0.16 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 777215 c.1266C>G synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 777218 c.1263G>A synonymous_variant 0.16 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.19 streptomycin
rpsL 781595 c.36T>C synonymous_variant 0.23 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.23 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.23 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.28 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.32 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.38 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.39 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.49 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.46 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.46 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.46 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.47 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.47 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.48 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.48 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.48 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.46 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.37 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.37 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.3 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.26 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.27 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.28 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.25 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.26 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.28 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.25 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.27 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.29 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.29 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 1.0 linezolid Not assoc w R
rplC 800516 c.-293G>T upstream_gene_variant 0.21 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.28 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.28 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.33 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.4 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.41 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.51 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.51 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.51 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.51 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.53 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.52 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.51 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.49 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.49 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.49 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.39 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.37 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.39 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.38 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.38 linezolid
rplC 800814 c.6A>G synonymous_variant 0.34 linezolid
rplC 800817 c.9A>T synonymous_variant 0.34 linezolid
rplC 800844 c.36T>C synonymous_variant 0.35 linezolid
rplC 800865 c.57A>G synonymous_variant 0.31 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.31 linezolid
rplC 800874 c.66A>G synonymous_variant 0.29 linezolid
rplC 800875 c.67_69delGTAinsAT frameshift_variant&missense_variant 0.29 linezolid
rplC 800880 c.72A>G synonymous_variant 0.3 linezolid
rplC 800889 c.81C>G synonymous_variant 0.29 linezolid
rplC 800892 c.84G>C synonymous_variant 0.29 linezolid
rplC 800907 c.99C>G synonymous_variant 0.29 linezolid
rplC 800916 c.108A>G synonymous_variant 0.25 linezolid
rplC 800934 c.126C>G synonymous_variant 0.16 linezolid
rplC 800939 p.Arg44His missense_variant 0.15 linezolid
rplC 801195 c.387G>C synonymous_variant 0.2 linezolid
rplC 801207 c.399C>T synonymous_variant 0.19 linezolid
rplC 801246 c.438C>T synonymous_variant 0.24 linezolid
rplC 801249 c.441T>C synonymous_variant 0.24 linezolid
rplC 801255 c.447C>T synonymous_variant 0.25 linezolid
rplC 801264 c.456C>T synonymous_variant 0.21 linezolid
rplC 801267 c.459A>T synonymous_variant 0.2 linezolid
rplC 801270 c.462T>C synonymous_variant 0.21 linezolid
rplC 801276 c.468G>C synonymous_variant 0.2 linezolid
rplC 801279 c.471G>C synonymous_variant 0.2 linezolid
rplC 801282 c.474G>C synonymous_variant 0.2 linezolid
rplC 801285 c.477G>C synonymous_variant 0.22 linezolid
rplC 801300 c.492C>G synonymous_variant 0.26 linezolid
rplC 801309 c.501C>G synonymous_variant 0.28 linezolid
rplC 801312 c.504G>C synonymous_variant 0.27 linezolid
rplC 801321 c.513C>T synonymous_variant 0.24 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.24 linezolid
rplC 801339 c.531T>C synonymous_variant 0.23 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.22 linezolid
rplC 801348 c.540T>G synonymous_variant 0.22 linezolid
rplC 801357 c.549T>C synonymous_variant 0.23 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.21 linezolid
rplC 801402 c.594T>C synonymous_variant 0.31 linezolid
rplC 801405 c.597T>C synonymous_variant 0.3 linezolid
rplC 801423 c.615G>C synonymous_variant 0.28 linezolid
rplC 801426 c.618C>G synonymous_variant 0.29 linezolid
rplC 801427 p.Met207Val missense_variant 0.32 linezolid
rplC 801438 c.630T>C synonymous_variant 0.26 linezolid
rplC 801442 p.Ile212Val missense_variant 0.29 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303501 c.571C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303509 c.579G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303521 c.591C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303530 c.600G>A synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303602 c.672A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303641 c.711C>T synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303650 c.720G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303654 c.724C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303661 p.Val244Ala missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303663 c.733C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303671 c.741C>T synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303681 c.751T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303704 c.774T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303998 c.1068T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305276 c.2346G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305279 p.His783Gln missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305282 c.2352T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305310 p.Arg794Gly missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305318 c.2388C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
embR 1417019 p.Cys110Tyr missense_variant 1.0 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 1.0 ethambutol
atpE 1460882 c.-163T>C upstream_gene_variant 0.15 bedaquiline
atpE 1461113 c.69C>T synonymous_variant 0.19 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.2 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.22 bedaquiline
atpE 1461150 c.106_108delATCinsGT frameshift_variant&missense_variant 0.22 bedaquiline
atpE 1461158 c.114T>G synonymous_variant 0.22 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.22 bedaquiline Uncertain significance
atpE 1461170 c.126A>G synonymous_variant 0.22 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.22 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.2 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.19 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.31 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.37 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.53 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.36 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.35 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673955 c.-247G>C upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1673985 c.-217C>G upstream_gene_variant 0.25 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.26 ethionamide
isoniazid
inhA 1674015 c.-187C>T upstream_gene_variant 0.23 ethionamide
isoniazid Uncertain significance
inhA 1674018 c.-184G>C upstream_gene_variant 0.23 ethionamide
isoniazid
inhA 1674021 c.-181G>C upstream_gene_variant 0.23 ethionamide
isoniazid
inhA 1674024 c.-178T>C upstream_gene_variant 0.23 ethionamide
isoniazid
inhA 1674033 c.-169T>C upstream_gene_variant 0.23 ethionamide
isoniazid
fabG1 1674037 p.Gln200Ala missense_variant 0.23 ethionamide
isoniazid
inhA 1674042 c.-160G>T upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1674049 c.610_612delCAAinsGC frameshift_variant&missense_variant 0.23 ethionamide
isoniazid
inhA 1674054 c.-148T>C upstream_gene_variant 0.23 ethionamide
isoniazid
inhA 1674060 c.-142A>G upstream_gene_variant 0.23 ethionamide
isoniazid
inhA 1674063 c.-139G>C upstream_gene_variant 0.23 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.22 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.19 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.3 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.41 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.42 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.46 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.46 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.44 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.43 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.42 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.43 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.41 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.41 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.46 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.43 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.32 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.4 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.37 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834169 p.Thr210Ala missense_variant 0.2 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.3 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.34 pyrazinamide
rpsA 1834288 c.747C>T synonymous_variant 0.66 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.26 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.28 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.29 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.28 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.26 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.42 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.43 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.43 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.42 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.33 linezolid
tsnR 1853423 c.-183C>T upstream_gene_variant 0.34 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.33 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.32 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.25 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.21 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.19 linezolid
tsnR 1853468 c.-138C>G upstream_gene_variant 0.18 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.17 linezolid
tsnR 1853481 c.-125A>G upstream_gene_variant 0.16 linezolid
tsnR 1853484 c.-122_-120delAGCinsGCG upstream_gene_variant 0.16 linezolid
tsnR 1853495 c.-111G>C upstream_gene_variant 0.16 linezolid
tsnR 1853974 c.369C>T synonymous_variant 1.0 linezolid Not assoc w R
tsnR 1854045 p.Tyr147Cys missense_variant 1.0 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2064912 c.-184A>G upstream_gene_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064933 c.-205A>G upstream_gene_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064936 c.-208C>G upstream_gene_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064942 c.-214G>A upstream_gene_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.29 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.31 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.35 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101804 c.1239T>G synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2101808 p.Thr412Ser missense_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101830 p.Ile405Val missense_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101837 p.Ala402Val missense_variant 0.25 ethionamide Uncertain significance
delamanid
isoniazid Uncertain significance
ndh 2101885 c.1158G>A synonymous_variant 0.2 ethionamide
delamanid
isoniazid
ndh 2101888 c.1155T>C synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2101894 c.1149T>G synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2101912 c.1131G>C synonymous_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2101920 c.1123A>C synonymous_variant 0.29 ethionamide
delamanid
isoniazid
ndh 2101924 c.1119T>G synonymous_variant 0.28 ethionamide
delamanid
isoniazid
ndh 2101939 c.1104A>G synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2101960 c.1083A>G synonymous_variant 0.16 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155637 p.Leu159Ile missense_variant 0.17 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.17 isoniazid Uncertain significance
katG 2155661 p.Val151Ile missense_variant 0.21 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.2 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.21 isoniazid
katG 2155695 c.417C>G synonymous_variant 0.21 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.22 isoniazid
katG 2155716 c.396T>G synonymous_variant 0.21 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.2 isoniazid
katG 2155728 c.384G>C synonymous_variant 0.21 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.21 isoniazid
katG 2155743 c.369G>C synonymous_variant 0.21 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2167983 p.Gly877Asp missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517950 c.-165C>G upstream_gene_variant 0.28 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.17 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.16 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.18 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.22 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.31 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.32 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.33 isoniazid
kasA 2518693 c.579C>G synonymous_variant 0.33 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.34 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.33 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.34 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.33 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.34 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.36 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.36 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.38 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.42 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.41 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.38 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.36 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.36 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.36 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.28 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.25 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.19 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.17 isoniazid
kasA 2519196 p.Thr361Ser missense_variant 0.25 isoniazid
kasA 2519215 c.1101C>T synonymous_variant 0.22 isoniazid
kasA 2519218 c.1104G>A synonymous_variant 0.23 isoniazid
kasA 2519221 c.1107G>C synonymous_variant 0.22 isoniazid
kasA 2519227 c.1113G>C synonymous_variant 0.2 isoniazid
kasA 2519230 c.1116C>T synonymous_variant 0.2 isoniazid
kasA 2519236 c.1122G>A synonymous_variant 0.2 isoniazid
kasA 2519239 c.1125A>C synonymous_variant 0.2 isoniazid
kasA 2519245 c.1131T>C synonymous_variant 0.19 isoniazid
kasA 2519260 c.1146T>G synonymous_variant 0.19 isoniazid
kasA 2519263 c.1149C>T synonymous_variant 0.19 isoniazid
kasA 2519266 c.1152C>T synonymous_variant 0.19 isoniazid
kasA 2519269 c.1155C>T synonymous_variant 0.19 isoniazid
kasA 2519272 c.1158C>G synonymous_variant 0.18 isoniazid
kasA 2519281 c.1167G>T synonymous_variant 0.16 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0 isoniazid
folC 2746420 c.1179A>C synonymous_variant 1.0 para-aminosalicylic_acid
Rv2477c 2782441 c.1602G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782450 c.1593C>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782453 c.1590C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782852 c.1191T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782861 c.1182T>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782864 c.1179T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782869 p.Ala392Thr missense_variant 0.23 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782876 c.1167G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782882 c.1161T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782966 c.1077C>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783425 c.616_618delCCCinsGG frameshift_variant&missense_variant 0.24 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783428 c.615C>T synonymous_variant 0.22 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783431 c.610_612delAGCinsTCG synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783437 c.606G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783464 c.579A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783497 c.544_546delTTGinsCC frameshift_variant&missense_variant 0.25 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783502 c.541T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784396 c.-354A>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784411 c.-369G>C upstream_gene_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784429 c.-387A>G upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784432 c.-390A>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784435 c.-393C>G upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784472 c.-430C>A upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784501 c.-459T>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784507 c.-465C>G upstream_gene_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2681 2996912 c.174C>T synonymous_variant 1.0 capreomycin Not assoc w R
Rv2752c 3064632 c.1560C>T synonymous_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067223 c.723G>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067232 c.714C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067249 p.Thr233Ser missense_variant 0.16 para-aminosalicylic_acid
thyX 3067252 p.Val232Met missense_variant 0.16 para-aminosalicylic_acid
thyX 3067284 p.Ala221Gly missense_variant 0.16 para-aminosalicylic_acid
thyX 3067292 c.654G>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067295 c.651C>T synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.18 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 0.32 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067736 c.208_210delTTCinsCT frameshift_variant&missense_variant 0.27 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067762 c.184C>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.17 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067781 c.165C>A synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.21 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.19 para-aminosalicylic_acid
thyA 3073860 c.612C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.17 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073898 p.Ala192Ser missense_variant 0.19 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074079 c.393G>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074100 c.370_372delGATinsAC frameshift_variant&synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074127 c.345G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074163 c.307_309delGCTinsAG frameshift_variant&missense_variant 0.2 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.2 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.19 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087672 p.His285Asp missense_variant 0.22 cycloserine
ald 3087680 c.861G>C synonymous_variant 0.21 cycloserine
ald 3087704 c.885T>C synonymous_variant 0.22 cycloserine
ald 3087716 c.897G>C synonymous_variant 0.18 cycloserine
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
lpqB 3623561 c.1350T>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624077 c.834G>A synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624082 c.829A>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624116 c.795A>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624119 c.792C>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624124 p.Leu263Val missense_variant 0.16 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624143 c.768T>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624166 p.Met249Leu missense_variant 0.16 bedaquiline
rifampicin
lpqB 3624167 c.744C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624173 c.738A>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624185 c.726C>T synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625135 c.1479A>G synonymous_variant 0.16 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625138 c.-228C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625141 c.-231T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 0.16 bedaquiline
rifampicin
lpqB 3625525 c.-615G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.15 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625549 c.-639G>A upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.26 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.36 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.31 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625749 c.-839C>T upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625750 c.864G>A synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.18 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.24 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626467 c.147G>A synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
mtrB 3626687 c.-74G>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.41 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.43 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.4 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.51 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.53 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.51 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.44 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.48 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.5 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.49 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.35 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.29 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
rpoA 3877494 p.Glu338Asp missense_variant 0.2 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.19 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.2 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.23 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.38 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.45 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.48 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.53 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.51 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.46 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.37 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.49 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.49 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.5 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.5 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.48 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.47 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.47 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.46 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.45 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.34 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.27 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.23 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.24 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.22 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.21 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.19 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.19 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.19 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.19 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.19 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.21 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.24 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.29 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.38 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.4 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.44 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.49 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.43 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.43 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.45 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.43 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.42 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.42 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.39 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.33 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.31 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.32 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.3 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.24 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.22 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.23 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.22 rifampicin
rpoA 3878672 c.-165A>T upstream_gene_variant 0.32 rifampicin
rpoA 3878683 c.-176G>C upstream_gene_variant 0.29 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.27 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.28 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.27 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.26 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.26 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.29 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.29 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.3 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.35 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.35 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.35 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.33 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.32 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.31 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.36 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.36 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.37 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.37 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.37 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.39 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.44 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.42 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.4 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.42 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.43 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.41 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.41 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.4 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.4 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.34 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.33 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.32 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.32 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.28 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.28 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.17 delamanid
pretomanid
clpC1 4038392 c.2313C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.15 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.16 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.28 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.29 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.24 pyrazinamide
clpC1 4038695 c.2010C>G synonymous_variant 0.26 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.34 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.35 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.38 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.48 pyrazinamide
clpC1 4038821 c.1884G>A synonymous_variant 0.48 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.48 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.49 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.49 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.48 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.45 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.37 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.28 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.22 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.21 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.36 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.4 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.43 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.46 pyrazinamide
clpC1 4039625 c.1080G>A synonymous_variant 0.43 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.37 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040291 c.414G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.22 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.22 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.23 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040444 c.261C>T synonymous_variant 0.17 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.17 pyrazinamide
clpC1 4040501 c.204C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040517 p.Val63Ala missense_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.22 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040567 c.138C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040570 c.135C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040582 c.123G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040588 c.117T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040596 c.109C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCG frameshift_variant&missense_variant 0.17 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.17 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.17 pyrazinamide
panD 4044740 c.-459C>T upstream_gene_variant 0.98 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4138622 c.1134C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138625 c.1131G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138646 c.1110G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138654 c.1102C>T synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.31 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.34 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138802 c.954G>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138808 c.948G>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138817 c.939T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138822 p.Asn312Asp missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138829 c.927A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138838 c.918G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138841 c.915G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138847 c.909A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138853 c.903C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240178 c.316T>C synonymous_variant 0.25 ethambutol
embC 4240183 c.321A>G synonymous_variant 0.24 ethambutol
embC 4240204 c.342T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4240210 c.348C>G synonymous_variant 0.24 ethambutol
embC 4240216 c.354T>C synonymous_variant 0.2 ethambutol
embC 4240222 c.360G>C synonymous_variant 0.18 ethambutol
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4240726 c.864G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.28 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.28 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.31 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.29 ethambutol
embC 4240828 c.966G>C synonymous_variant 0.27 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.27 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.22 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.17 ethambutol
embC 4240873 c.1011C>G synonymous_variant 0.17 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.17 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.16 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.17 ethambutol
embC 4241042 p.Asn394Asp missense_variant 0.83 ethambutol Not assoc w R
embC 4241047 c.1185C>G synonymous_variant 0.17 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.17 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.18 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.28 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.29 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.29 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.29 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.24 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.24 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.24 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.24 ethambutol
embC 4241351 p.Ile497Val missense_variant 0.16 ethambutol
embC 4241361 p.Asn500Thr missense_variant 0.16 ethambutol
embC 4241363 c.1501_1503delCTCinsAG frameshift_variant&missense_variant 0.16 ethambutol
embC 4241374 c.1512T>C synonymous_variant 0.2 ethambutol
embC 4241380 c.1518A>C synonymous_variant 0.2 ethambutol
embC 4241383 c.1521G>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241392 c.1530G>C synonymous_variant 0.23 ethambutol
embC 4241394 p.Lys511Ser missense_variant 0.22 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.22 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.19 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.18 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.18 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.17 ethambutol
embC 4241500 c.1638A>C synonymous_variant 0.17 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.16 ethambutol
embC 4241506 c.1644G>C synonymous_variant 0.16 ethambutol
embC 4241518 c.1656A>G synonymous_variant 0.15 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242715 c.2853T>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embA 4242742 c.-491C>G upstream_gene_variant 0.25 ethambutol
embA 4242748 c.-485A>G upstream_gene_variant 0.27 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.29 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.29 ethambutol
embC 4242779 p.Asn973Asp missense_variant 0.34 ethambutol
embC 4242791 c.2929_2931delGCAinsTC frameshift_variant&missense_variant 0.34 ethambutol
embA 4242796 c.-437G>C upstream_gene_variant 0.33 ethambutol
embA 4242799 c.-434T>C upstream_gene_variant 0.34 ethambutol
embA 4242820 c.-413G>C upstream_gene_variant 0.35 ethambutol
embA 4242823 c.-410G>C upstream_gene_variant 0.36 ethambutol
embA 4242832 c.-401A>C upstream_gene_variant 0.33 ethambutol
embA 4242838 c.-395C>G upstream_gene_variant 0.35 ethambutol
embC 4242841 c.2979C>T synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embA 4242844 c.-389A>G upstream_gene_variant 0.33 ethambutol
embA 4242847 c.-386C>A upstream_gene_variant 0.33 ethambutol
embA 4242859 c.-374C>T upstream_gene_variant 0.31 ethambutol
embA 4242862 c.-371A>G upstream_gene_variant 0.32 ethambutol
embC 4242863 p.Tyr1001Asn missense_variant 0.32 ethambutol
embC 4242883 c.3021C>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embA 4242892 c.-341G>C upstream_gene_variant 0.24 ethambutol
embA 4242901 c.-332G>C upstream_gene_variant 0.23 ethambutol
embA 4242919 c.-314A>G upstream_gene_variant 0.18 ethambutol
embA 4243848 p.Val206Met missense_variant 1.0 ethambutol Not assoc w R
embA 4245218 c.1986C>T synonymous_variant 0.87 ethambutol Not assoc w R
embA 4245969 p.Pro913Ser missense_variant 1.0 ethambutol Not assoc w R
embA 4246080 c.2848_2850delCCTinsTC frameshift_variant&missense_variant 0.17 ethambutol Uncertain significance
embA 4246088 c.2856A>G synonymous_variant 0.2 ethambutol Not assoc w R
embB 4246097 c.-417C>G upstream_gene_variant 0.2 ethambutol
embA 4246103 c.2871C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4246109 c.-405C>G upstream_gene_variant 0.2 ethambutol
embB 4246115 c.-399T>G upstream_gene_variant 0.21 ethambutol
embA 4246128 c.2896_2898delTCTinsAC frameshift_variant&missense_variant 0.23 ethambutol Uncertain significance
embA 4246138 p.Arg969Gln missense_variant 0.22 ethambutol
embB 4246140 c.-374T>C upstream_gene_variant 0.22 ethambutol
embA 4246143 p.Ile971Val missense_variant 0.22 ethambutol
embA 4246151 c.2919A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embA 4246152 p.Ala974Gln missense_variant 0.22 ethambutol
embB 4246157 c.-357A>G upstream_gene_variant 0.22 ethambutol
embA 4246164 c.2932T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4246184 c.-330A>C upstream_gene_variant 0.21 ethambutol
embB 4246196 c.-318C>G upstream_gene_variant 0.22 ethambutol
embB 4246205 c.-309A>G upstream_gene_variant 0.18 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.16 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.17 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.26 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.28 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.31 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.29 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.3 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.26 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.25 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.21 ethambutol
embB 4247587 c.1074G>A synonymous_variant 0.21 ethambutol
embB 4247588 c.1075_1077delCTAinsAC frameshift_variant&missense_variant 0.21 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.2 ethambutol
embB 4247611 c.1098G>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247614 c.1101T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247773 c.1260G>A synonymous_variant 0.16 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.18 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.25 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.25 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.24 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.22 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.22 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.19 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.17 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.17 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.16 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248130 c.1617G>C synonymous_variant 0.18 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.16 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.16 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248199 c.1686A>G synonymous_variant 0.24 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.24 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.24 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.24 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.24 ethambutol
embB 4249369 c.2856T>C synonymous_variant 0.17 ethambutol
embB 4249375 c.2862G>C synonymous_variant 0.2 ethambutol
embB 4249381 c.2868A>G synonymous_variant 0.19 ethambutol
embB 4249384 c.2871G>T synonymous_variant 0.2 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.22 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.19 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.19 ethambutol
embB 4249429 c.2916C>T synonymous_variant 0.21 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.23 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.25 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.36 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.4 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.41 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.34 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.34 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.33 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.33 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.33 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.33 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.3 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.28 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.28 ethambutol
embB 4249580 p.Leu1023Met missense_variant 0.25 ethambutol
embB 4249594 c.3081G>C synonymous_variant 0.21 ethambutol
aftB 4267268 c.1569T>C synonymous_variant 0.16 ethambutol
aftB 4267325 c.1512G>C synonymous_variant 0.16 ethambutol
aftB 4267334 c.1503T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
aftB 4268123 c.714T>C synonymous_variant 0.16 ethambutol
aftB 4268129 c.708T>G synonymous_variant 0.16 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
aftB 4268164 p.Gln225Glu missense_variant 0.18 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.17 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.17 ethambutol
aftB 4268182 p.Phe219Leu missense_variant 0.17 ethambutol
aftB 4268183 c.654A>T synonymous_variant 0.17 ethambutol
aftB 4268193 p.Leu215Ala missense_variant 0.17 ethambutol
aftB 4268205 p.Val211Ala missense_variant 0.16 ethambutol
ubiA 4269031 p.Gly268Asp missense_variant 0.9 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 1.0 streptomycin Not assoc w R