TB-Profiler result

Run: SRR6045795
Summary

Run ID: SRR6045795

Sample name:

Date: 2024-10-04T09:56:09.933194

Number of reads: 478449

Percentage reads mapped: 35.79

Median coverage: 13.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.96
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 609 c.609C>G synonymous_variant 0.42 isoniazid
dnaA 627 c.627G>A synonymous_variant 0.52 isoniazid
dnaA 633 c.633T>C synonymous_variant 0.52 isoniazid
dnaA 648 c.648C>T synonymous_variant 0.53 isoniazid
dnaA 651 c.651G>A synonymous_variant 0.5 isoniazid
dnaA 654 c.654A>G synonymous_variant 0.5 isoniazid
dnaA 660 c.660G>A synonymous_variant 0.5 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.44 isoniazid
dnaA 682 c.682_684delTTGinsCTC synonymous_variant 0.39 isoniazid
dnaA 687 c.687C>T synonymous_variant 0.39 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.39 isoniazid Not assoc w R - Interim
dnaA 699 c.699G>T synonymous_variant 0.44 isoniazid
dnaA 702 c.702C>G synonymous_variant 0.44 isoniazid
dnaA 705 c.705A>G synonymous_variant 0.41 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.41 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.35 isoniazid Not assoc w R - Interim
dnaA 897 c.897A>G synonymous_variant 0.43 isoniazid
dnaA 909 c.909A>C synonymous_variant 0.5 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>G synonymous_variant 0.5 isoniazid
dnaA 919 p.Pro307Ser missense_variant 0.53 isoniazid Uncertain significance
dnaA 927 c.927G>A synonymous_variant 0.47 isoniazid
dnaA 933 c.933C>G synonymous_variant 0.47 isoniazid
dnaA 955 c.955_957delAGAinsCGG synonymous_variant 0.47 isoniazid
dnaA 963 c.963C>T synonymous_variant 0.47 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.47 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.47 isoniazid
dnaA 975 c.975G>C synonymous_variant 0.5 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.53 isoniazid Not assoc w R - Interim
dnaA 987 c.987C>T synonymous_variant 0.5 isoniazid
dnaA 990 c.990A>G synonymous_variant 0.5 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.53 isoniazid
dnaA 996 c.996A>T synonymous_variant 0.58 isoniazid
dnaA 1003 c.1003C>T synonymous_variant 0.57 isoniazid
dnaA 1023 c.1023C>T synonymous_variant 0.4 isoniazid
gyrB 6100 c.861G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrB 6103 c.864G>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrB 6109 c.870G>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrB 6130 c.891T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6133 c.894G>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6154 c.915C>G synonymous_variant 0.47 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6175 c.936G>A synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrB 6178 c.939C>T synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrB 6196 c.957C>T synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7715 c.414G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7742 c.441G>A synonymous_variant 0.44 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 7775 c.474C>T synonymous_variant 0.57 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7778 c.477G>C synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.57 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.52 levofloxacin
moxifloxacin
gyrA 7799 c.498A>T synonymous_variant 0.5 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.48 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7853 c.552C>T synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>C synonymous_variant 0.45 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>G synonymous_variant 0.33 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9386 c.2085T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9419 c.2118T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9420 p.Ile707Glu missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 9425 p.Asp708Glu missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 9430 p.Arg710Gln missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 9452 c.2151G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9455 c.2154T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9464 c.2163C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9468 c.2167C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9476 c.2175G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9485 c.2184A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
fgd1 490896 c.114C>T synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 490899 c.117C>T synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fgd1 490911 c.129T>G synonymous_variant 0.42 pretomanid
delamanid
clofazimine
fgd1 490921 p.Gln47Glu missense_variant 0.5 pretomanid
delamanid
clofazimine
fgd1 490948 p.Ser56Ala missense_variant 0.52 pretomanid
delamanid
clofazimine
fgd1 490962 c.180T>C synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fgd1 490971 c.189A>G synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fgd1 490974 c.192T>C synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fgd1 490978 p.Asn66Glu missense_variant 0.48 pretomanid
delamanid
clofazimine
fgd1 490983 c.201G>A synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fgd1 490987 p.Leu69Ile missense_variant 0.53 pretomanid
delamanid
clofazimine
fgd1 490998 c.216T>C synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fgd1 491013 c.231C>G synonymous_variant 0.57 pretomanid
delamanid
clofazimine
fgd1 491016 c.234C>G synonymous_variant 0.52 pretomanid
delamanid
clofazimine
fgd1 491031 c.249C>G synonymous_variant 0.48 pretomanid
delamanid
clofazimine
fgd1 491037 c.255C>G synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fgd1 491043 c.261T>G synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fgd1 491049 c.267T>G synonymous_variant 0.44 pretomanid
delamanid
clofazimine
fgd1 491094 c.312C>T synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491115 c.333G>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fgd1 491121 c.339A>G synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fgd1 491133 c.351A>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fgd1 491142 c.360C>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 491144 p.Ala121Glu missense_variant 0.36 pretomanid
delamanid
clofazimine
mshA 575907 p.Ala187Val missense_variant 1.0 isoniazid Not assoc w R
ethionamide Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
nusG 734460 c.207G>C synonymous_variant 0.47 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.47 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.44 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.5 rifampicin
nusG 734571 c.318C>G synonymous_variant 0.5 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>G synonymous_variant 0.36 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.44 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.48 rifampicin
rpoB 760145 c.339C>G synonymous_variant 0.48 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760415 c.609C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760511 c.705G>C synonymous_variant 0.55 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.57 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.5 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 0.46 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 0.46 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.48 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.65 rifampicin
rpoB 760595 c.789C>A synonymous_variant 0.64 rifampicin
rpoB 760601 c.795C>T synonymous_variant 0.62 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 760625 c.819C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.38 rifampicin
rpoB 761036 c.1230G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.39 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.39 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.41 rifampicin
rpoB 761570 c.1764T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761591 c.1785C>T synonymous_variant 0.5 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.44 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.43 rifampicin
rpoB 761661 c.1855C>T synonymous_variant 0.43 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.45 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.42 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.42 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761951 c.2145G>C synonymous_variant 0.3 rifampicin
rpoB 761955 p.Ile717Val missense_variant 0.3 rifampicin Uncertain significance
rpoB 761972 c.2166C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761984 c.2178G>A synonymous_variant 0.43 rifampicin
rpoB 761999 c.2193G>C synonymous_variant 0.5 rifampicin
rpoB 762004 p.Asn733Ser missense_variant 0.5 rifampicin Uncertain significance
rpoB 762008 c.2202C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.48 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.56 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.67 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.65 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.65 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762156 p.Val784Ile missense_variant 0.75 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762170 c.2364C>A synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.6 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>G synonymous_variant 0.37 rifampicin
rpoB 762299 c.2493G>C synonymous_variant 0.35 rifampicin
rpoB 762308 c.2502G>C synonymous_variant 0.31 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.29 rifampicin
rpoB 762341 c.2535G>C synonymous_variant 0.29 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.29 rifampicin
rpoB 762359 c.2553C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762362 p.Glu852Asp missense_variant 0.3 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.5 rifampicin Uncertain significance
rpoB 762899 c.3093G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.55 rifampicin
rpoB 762995 c.3189G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.44 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763053 c.-317_-315delTTGinsCTC upstream_gene_variant 0.46 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.47 rifampicin
rpoC 763079 c.-291C>G upstream_gene_variant 0.47 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.45 rifampicin
rpoC 763160 c.-210G>T upstream_gene_variant 0.47 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.41 rifampicin
rpoC 763375 c.6C>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>C synonymous_variant 0.43 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763423 p.Glu18Asp missense_variant 0.43 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCGT synonymous_variant 0.43 rifampicin
rpoC 763433 p.Gln22Asn missense_variant 0.48 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.5 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>A synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 763621 c.252C>T synonymous_variant 0.58 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763651 c.282C>T synonymous_variant 0.5 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.46 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764320 c.951C>G synonymous_variant 0.44 rifampicin
rpoC 764341 c.972G>T synonymous_variant 0.44 rifampicin
rpoC 764359 c.990C>G synonymous_variant 0.5 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764800 c.1431G>A synonymous_variant 0.6 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.6 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.38 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCTC synonymous_variant 0.43 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.37 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.37 rifampicin Uncertain significance
rpoC 764920 c.1551G>C synonymous_variant 0.43 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.48 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765861 p.Phe831Tyr missense_variant 0.45 rifampicin Uncertain significance
rpoC 765875 p.Val836Ile missense_variant 0.44 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.36 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.3 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766738 c.3369G>T synonymous_variant 0.5 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.5 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.5 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>T synonymous_variant 0.56 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.56 rifampicin
rpoC 766777 c.3408C>G synonymous_variant 0.56 rifampicin
rpoC 766795 c.3426C>T synonymous_variant 0.63 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.4 rifampicin
rpoC 767267 p.Ala1300Ser missense_variant 0.4 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767296 c.3927C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767302 c.3933C>A synonymous_variant 0.33 rifampicin
mmpL5 775841 c.2640G>C synonymous_variant 0.52 bedaquiline
clofazimine
mmpL5 775847 c.2634G>T synonymous_variant 0.34 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R - Interim
mmpL5 775847 c.2634G>C synonymous_variant 0.45 bedaquiline
clofazimine
mmpL5 775851 p.Ser877Thr missense_variant 0.36 bedaquiline
clofazimine
mmpL5 775856 c.2625T>C synonymous_variant 0.73 bedaquiline
clofazimine
mmpL5 775862 c.2619G>C synonymous_variant 0.73 bedaquiline
clofazimine
mmpL5 775865 c.2616T>C synonymous_variant 0.76 bedaquiline
clofazimine
mmpL5 775883 p.Ile866Leu missense_variant 0.68 bedaquiline
clofazimine
mmpL5 775895 c.2586C>A synonymous_variant 0.68 bedaquiline
clofazimine
mmpL5 775901 c.2580G>A synonymous_variant 0.66 bedaquiline
clofazimine
mmpL5 775907 c.2572_2574delCTCinsTTG synonymous_variant 0.68 bedaquiline
clofazimine
mmpL5 775910 c.2571G>A synonymous_variant 0.54 bedaquiline
clofazimine
mmpL5 775913 c.2568C>G synonymous_variant 0.67 bedaquiline
clofazimine
mmpL5 775916 c.2565T>C synonymous_variant 0.67 bedaquiline
clofazimine
mmpL5 775946 c.2535C>G synonymous_variant 0.39 bedaquiline
clofazimine
mmpL5 775951 c.2530C>T synonymous_variant 0.57 bedaquiline
clofazimine
mmpL5 775955 p.Ile842Val missense_variant 0.31 bedaquiline
clofazimine
mmpL5 775961 c.2520C>G synonymous_variant 0.69 bedaquiline
clofazimine
mmpL5 775972 p.Ala837Pro missense_variant 0.19 bedaquiline
clofazimine
mmpL5 775973 c.2506_2508delTTGinsCTA synonymous_variant 0.19 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.59 bedaquiline
clofazimine
mmpL5 775996 p.Ile829Val missense_variant 0.31 bedaquiline Uncertain significance
clofazimine Uncertain significance
mmpL5 776002 c.2479C>T synonymous_variant 0.3 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.5 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.48 streptomycin
rpsL 781718 c.159C>T synonymous_variant 0.5 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.5 streptomycin
rpsL 781732 c.174_177delGAGT frameshift_variant 0.4 streptomycin Uncertain significance
rpsL 781739 c.180_183delGGTCinsCCGGGGTT frameshift_variant&stop_gained&missense_variant 0.4 streptomycin Uncertain significance
rpsL 781751 c.192G>C synonymous_variant 0.4 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.38 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.42 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.43 streptomycin
rpsL 781769 c.210G>A synonymous_variant 0.54 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.67 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.68 streptomycin
rpsL 781829 c.270G>T synonymous_variant 0.65 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.67 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.77 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.71 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.69 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.72 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.7 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.69 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.69 streptomycin
rplC 800645 c.-164C>G upstream_gene_variant 0.5 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.61 linezolid
rplC 800651 c.-158G>C upstream_gene_variant 0.58 linezolid
rplC 800678 c.-131C>T upstream_gene_variant 0.47 linezolid
rplC 800684 c.-125G>A upstream_gene_variant 0.47 linezolid
rplC 800690 c.-119C>G upstream_gene_variant 0.47 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.5 linezolid
rplC 800702 c.-107G>C upstream_gene_variant 0.5 linezolid
rplC 800703 c.-106_-104delTTGinsCTT upstream_gene_variant 0.5 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.59 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.53 linezolid
rplC 800744 c.-65G>C upstream_gene_variant 0.47 linezolid
rplC 800745 c.-64_-62delCTCinsTTG upstream_gene_variant 0.45 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.41 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.41 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.37 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303515 c.585G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303525 p.Ser199Thr missense_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303531 p.Met201Leu missense_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1303536 c.606G>A synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1303542 c.612C>G synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1303548 c.618G>C synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303551 c.621G>T synonymous_variant 0.5 pretomanid
delamanid
clofazimine
fbiC 1303560 c.630G>C synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1303584 c.654C>A synonymous_variant 0.56 pretomanid
delamanid
clofazimine
fbiC 1303602 c.672A>G synonymous_variant 0.53 pretomanid
delamanid
clofazimine
fbiC 1304607 c.1677C>T synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304724 c.1794A>G synonymous_variant 0.43 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304727 c.1797A>C synonymous_variant 0.45 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>G synonymous_variant 0.43 pretomanid
delamanid
clofazimine
fbiC 1304769 c.1839C>T synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
sigE 1364706 c.294G>A synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
sigE 1364709 c.297T>C synonymous_variant 0.41 pyrazinamide
sigE 1364712 c.300T>C synonymous_variant 0.41 pyrazinamide
sigE 1364715 c.303G>C synonymous_variant 0.41 pyrazinamide
sigE 1364721 c.309C>G synonymous_variant 0.43 pyrazinamide
sigE 1364729 p.Gln106Pro missense_variant 0.45 pyrazinamide
sigE 1364733 p.His107Gln missense_variant 0.43 pyrazinamide
sigE 1364736 c.324T>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
sigE 1364742 c.330A>G synonymous_variant 0.52 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.39 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.42 pyrazinamide
sigE 1364772 c.360G>C synonymous_variant 0.42 pyrazinamide
sigE 1364778 c.366G>C synonymous_variant 0.42 pyrazinamide
sigE 1364781 c.369G>C synonymous_variant 0.42 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.42 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.4 pyrazinamide
sigE 1364799 c.387G>C synonymous_variant 0.44 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.5 pyrazinamide
sigE 1364818 c.406_408delCTAinsTTG synonymous_variant 0.38 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.45 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.47 pyrazinamide
sigE 1364847 c.435G>C synonymous_variant 0.47 pyrazinamide
sigE 1364856 c.444C>G synonymous_variant 0.47 pyrazinamide
sigE 1364859 c.447C>G synonymous_variant 0.56 pyrazinamide
sigE 1364866 p.Ala152Thr missense_variant 0.56 pyrazinamide
sigE 1364871 c.459C>G synonymous_variant 0.5 pyrazinamide
sigE 1364877 c.465G>C synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
atpE 1461170 c.126A>G synonymous_variant 0.54 bedaquiline
atpE 1461179 c.135G>C synonymous_variant 0.5 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.5 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.5 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.44 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.44 bedaquiline
atpE 1461224 c.180T>G synonymous_variant 0.47 bedaquiline
atpE 1461230 c.186G>C synonymous_variant 0.4 bedaquiline
atpE 1461233 c.189A>G synonymous_variant 0.33 bedaquiline
atpE 1461254 c.210T>C synonymous_variant 0.33 bedaquiline
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.4 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.4 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.38 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.56 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.38 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.65 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsGT non_coding_transcript_exon_variant 0.68 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2103C>T non_coding_transcript_exon_variant 0.73 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.73 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.86 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>C non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rpsA 1833619 c.78A>C synonymous_variant 0.3 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833628 c.87G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.23 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1833709 c.168C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.28 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.26 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.35 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.38 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.39 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.43 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.39 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.47 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.5 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.47 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.42 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.41 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.48 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.48 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.43 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.42 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834096 c.555G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834108 c.567C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834249 c.708T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834252 c.711C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834298 p.Gln253Thr missense_variant 0.36 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.62 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.71 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.79 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.59 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.61 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.65 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.67 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.63 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.59 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.56 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.5 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.47 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.5 pyrazinamide Uncertain significance
rpsA 1834633 c.1092A>G synonymous_variant 0.73 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.76 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.76 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.94 pyrazinamide
rpsA 1834700 p.Gln387Ala missense_variant 1.0 pyrazinamide
rpsA 1834705 c.1164C>G synonymous_variant 1.0 pyrazinamide
rpsA 1834720 c.1179C>G synonymous_variant 0.88 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.81 pyrazinamide
rpsA 1834738 p.Glu399Asp missense_variant 0.74 pyrazinamide
rpsA 1834747 c.1206A>G synonymous_variant 0.74 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.65 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.61 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.57 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.52 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.52 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.52 pyrazinamide
rpsA 1834810 c.1269C>T synonymous_variant 0.43 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.65 isoniazid
kasA 2517953 c.-162C>T upstream_gene_variant 0.58 isoniazid
kasA 2517959 c.-156C>T upstream_gene_variant 0.57 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.57 isoniazid
kasA 2517968 c.-147T>C upstream_gene_variant 0.52 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.5 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.47 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.47 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.6 isoniazid
Rv2477c 2782453 c.1590C>T synonymous_variant 0.5 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782480 c.1563G>A synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.41 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
thyA 3073888 p.Ser195Gln missense_variant 0.62 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.62 para-aminosalicylic_acid
thyA 3073902 c.570C>T synonymous_variant 0.62 para-aminosalicylic_acid
thyA 3073905 c.567C>G synonymous_variant 0.62 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.61 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.59 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.47 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.43 para-aminosalicylic_acid
thyA 3073962 c.510G>C synonymous_variant 0.43 para-aminosalicylic_acid
ald 3087704 c.885T>C synonymous_variant 0.35 cycloserine
ald 3087716 c.897G>C synonymous_variant 0.4 cycloserine
ald 3087727 p.Ala303Gly missense_variant 0.38 cycloserine
ald 3087729 p.Ser304Ala missense_variant 0.38 cycloserine
ald 3087738 p.Lys307Arg missense_variant 0.38 cycloserine
ald 3087743 c.924G>A synonymous_variant 0.38 cycloserine
ald 3087752 c.933C>T synonymous_variant 0.38 cycloserine
mtrB 3625708 c.906C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625735 c.879C>A synonymous_variant 0.43 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625744 c.870G>A synonymous_variant 0.48 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625747 c.867G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.5 rifampicin Uncertain significance
bedaquiline
mtrB 3625762 c.852A>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625792 c.-882G>C upstream_gene_variant 0.52 rifampicin
bedaquiline
lpqB 3625795 c.-885G>C upstream_gene_variant 0.52 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625822 c.-912C>T upstream_gene_variant 0.41 rifampicin
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626747 c.-134G>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626750 c.-137T>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3626773 c.-160C>T upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3626776 c.-163A>C upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3626780 c.-167T>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3626783 c.-170C>G upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626786 c.-173A>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrA 3626789 c.561C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626810 c.-197A>G upstream_gene_variant 0.31 rifampicin
bedaquiline
rpoA 3877587 c.921A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877590 c.918G>C synonymous_variant 0.4 rifampicin
rpoA 3877593 c.915C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877602 c.906C>T synonymous_variant 0.63 rifampicin
rpoA 3877617 c.891G>C synonymous_variant 0.67 rifampicin
rpoA 3877647 c.861C>T synonymous_variant 0.64 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.61 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.59 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.57 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.61 rifampicin
rpoA 3877728 c.780C>G synonymous_variant 0.73 rifampicin
rpoA 3877731 c.777G>C synonymous_variant 0.73 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoA 3877746 c.762G>C synonymous_variant 0.68 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoA 3877770 c.735_738delGTCAinsCAGC synonymous_variant 0.72 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877854 c.652_654delTTGinsCTC synonymous_variant 0.68 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.68 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.68 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3877878 c.630G>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3877893 c.615C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.67 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.7 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.53 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.58 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878103 c.405A>G synonymous_variant 0.27 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.29 rifampicin
rpoA 3878244 c.264G>A synonymous_variant 0.35 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.35 rifampicin
clpC1 4038596 c.2109A>G synonymous_variant 0.33 pyrazinamide
clpC1 4038620 p.Gln695Leu missense_variant 0.27 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.41 pyrazinamide
clpC1 4038746 c.1959C>T synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4038749 c.1956C>T synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4038767 c.1938G>C synonymous_variant 0.55 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.5 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.5 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.5 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.57 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.57 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.56 pyrazinamide
clpC1 4038836 c.1869G>C synonymous_variant 0.61 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.62 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.58 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.5 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.39 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038977 c.1728G>C synonymous_variant 0.28 pyrazinamide
clpC1 4038983 c.1722C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039034 c.1671C>G synonymous_variant 0.45 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.51 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.51 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.55 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.55 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039119 c.1585_1586delTCinsAG synonymous_variant 0.55 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.53 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.53 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039154 c.1551G>C synonymous_variant 0.54 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.43 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.32 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039238 c.1467C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039241 c.1464G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039280 c.1425G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039415 p.Glu430Asp missense_variant 0.52 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.54 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.54 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.52 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.48 pyrazinamide
clpC1 4039484 c.1221T>G synonymous_variant 0.46 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.46 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039598 c.1107C>T synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039649 c.1056G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039655 c.1050G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.48 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.47 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.47 pyrazinamide
clpC1 4039823 c.882T>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.41 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.58 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.55 pyrazinamide
clpC1 4039916 c.789T>C synonymous_variant 0.5 pyrazinamide
clpC1 4039919 c.786C>T synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.62 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.57 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.62 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.64 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.59 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.48 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.43 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.45 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.44 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
clpC1 4040057 c.648C>T synonymous_variant 0.47 pyrazinamide
clpC1 4040066 c.639G>C synonymous_variant 0.44 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.5 pyrazinamide
clpC1 4040372 c.333C>G synonymous_variant 0.5 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.5 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.48 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.45 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4040450 c.255A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040462 c.243C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.39 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>T synonymous_variant 0.44 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.46 pyrazinamide
clpC1 4040513 c.192G>A synonymous_variant 0.57 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.52 pyrazinamide
clpC1 4040540 c.165G>C synonymous_variant 0.46 pyrazinamide
clpC1 4040543 c.162C>T synonymous_variant 0.4 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.4 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040558 c.147G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.32 pyrazinamide
clpC1 4040570 c.135C>G synonymous_variant 0.36 pyrazinamide
clpC1 4040573 c.132T>A synonymous_variant 0.36 pyrazinamide
clpC1 4040579 c.126A>G synonymous_variant 0.36 pyrazinamide
clpC1 4040582 c.123G>T synonymous_variant 0.35 pyrazinamide
clpC1 4040585 c.120A>G synonymous_variant 0.36 pyrazinamide
clpC1 4040588 c.117T>C synonymous_variant 0.38 pyrazinamide
clpC1 4040594 c.111G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCTC synonymous_variant 0.4 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.4 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.42 pyrazinamide
panD 4044150 c.132A>C synonymous_variant 0.38 pyrazinamide
panD 4044159 c.123C>T synonymous_variant 0.5 pyrazinamide
panD 4044165 c.117G>C synonymous_variant 0.53 pyrazinamide
panD 4044177 c.105C>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
panD 4044180 c.102C>T synonymous_variant 0.53 pyrazinamide
panD 4044188 c.94T>C synonymous_variant 0.53 pyrazinamide
panD 4044192 c.90C>G synonymous_variant 0.53 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.53 pyrazinamide
panD 4044210 c.72C>T synonymous_variant 0.53 pyrazinamide
panD 4044213 c.69C>G synonymous_variant 0.59 pyrazinamide
panD 4044231 p.Cys17Gln missense_variant 0.67 pyrazinamide
panD 4044252 c.30C>T synonymous_variant 0.67 pyrazinamide
panD 4044261 c.21G>A synonymous_variant 0.67 pyrazinamide Not assoc w R - Interim
panD 4044287 c.-6A>G upstream_gene_variant 0.67 pyrazinamide
glpK 4139537 c.219G>C synonymous_variant 0.82 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139541 p.Ile72Thr missense_variant 0.83 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139545 c.211T>C synonymous_variant 0.83 levofloxacin
moxifloxacin Not assoc w R - Interim
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139552 c.204G>C synonymous_variant 0.81 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139561 c.195G>A synonymous_variant 0.82 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139573 c.183C>G synonymous_variant 0.8 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139599 p.Ala53Pro missense_variant 0.76 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139601 p.Arg52Gln missense_variant 0.76 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139603 c.153C>G synonymous_variant 0.8 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139608 p.Leu50Met missense_variant 0.76 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139615 c.141G>A synonymous_variant 0.84 levofloxacin Not assoc w R - Interim
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
glpK 4139621 c.135G>A synonymous_variant 0.84 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
glpK 4139630 c.126C>T synonymous_variant 0.71 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139633 c.123C>T synonymous_variant 0.71 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139637 p.Ala40Gly missense_variant 0.75 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139652 p.His35Ala missense_variant 0.75 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139654 c.102C>T synonymous_variant 0.75 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
embC 4240768 c.906G>C synonymous_variant 0.35 ethambutol
embC 4240771 c.909G>C synonymous_variant 0.35 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.3 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.3 ethambutol
embC 4240786 c.924C>T synonymous_variant 0.28 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.26 ethambutol
embC 4240819 c.957A>C synonymous_variant 0.27 ethambutol
embC 4240822 c.960C>G synonymous_variant 0.26 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.29 ethambutol
embB 4247462 p.Ser317Ala missense_variant 0.46 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.46 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.5 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.5 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.5 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.4 ethambutol
embB 4247519 p.Leu336Val missense_variant 0.4 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R