TB-Profiler result

Run: ERR9786986

Summary

Run ID: ERR9786986

Sample name:

Date: 2024-03-24T19:26:30.991771

Number of reads: 895210

Percentage reads mapped: 77.16

Median coverage: 41.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: HR-TB


Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.94
lineage4.1.2 Euro-American None 0.99
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.98
lineage4 Euro-American None 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol
pyrazinamide
streptomycin gid c.102delG Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid folC p.Glu153Ala Mutation from literature
delamanid fbiC c.916_918delTTCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.925_927delGCCinsAG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303846 c.916_918delTTCinsGG frameshift_variant&missense_variant 0.19 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303855 c.925_927delGCCinsAG frameshift_variant&missense_variant 0.19 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
folC 2747141 p.Glu153Ala missense_variant 0.98 para-aminosalicylic_acid Mutation from literature
gid 4408100 c.102delG frameshift_variant 1.0 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 633 c.633T>G synonymous_variant 0.18 isoniazid
dnaA 636 c.636C>G synonymous_variant 0.17 isoniazid
dnaA 645 c.645A>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 657 c.657C>T synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 660 c.660G>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.19 isoniazid
dnaA 672 c.672T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 675 c.675C>G synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 678 c.678A>G synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 681 c.681G>A synonymous_variant 0.18 isoniazid
dnaA 682 c.682T>C synonymous_variant 0.18 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.21 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.19 isoniazid
dnaA 711 c.711C>G synonymous_variant 0.2 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>A synonymous_variant 0.25 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.26 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.25 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.24 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 802 c.802C>T synonymous_variant 0.26 isoniazid
dnaA 819 c.819C>T synonymous_variant 0.27 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.27 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.27 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.26 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.27 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.23 isoniazid
dnaA 864 c.864C>T synonymous_variant 0.23 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.19 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.21 isoniazid
dnaA 927 c.927G>A synonymous_variant 0.2 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.17 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.17 isoniazid
gyrB 6190 c.951A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.19 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6280 c.1041T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6299 c.1060C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8382 p.Leu361Met missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8510 c.1209G>A synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8591 c.1290C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8619 c.1318T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8720 c.1419G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8732 c.1431G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8751 p.Ala484Thr missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8894 c.1593C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8900 c.1599G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9038 c.1737C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9051 c.1750T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9062 c.1761C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9066 c.1765C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9074 c.1773G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9080 c.1779G>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9083 c.1782G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9089 c.1788G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9095 c.1794C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9099 c.1798_1800delTTAinsCG frameshift_variant&missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9661 p.Ala787Asp missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9674 c.2373T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
Rv0010c 13462 p.Asp33Tyr missense_variant 1.0 isoniazid Uncertain significance
fgd1 491022 c.240C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491496 c.714C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 491591 p.Lys270Met missense_variant 0.93 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575649 p.Val101Ala missense_variant 0.31 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.36 ethionamide
isoniazid
mshA 575665 c.318G>C synonymous_variant 0.39 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575679 p.Asn111Ser missense_variant 0.61 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575695 c.348C>G synonymous_variant 0.37 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.36 ethionamide
isoniazid
mshA 575728 c.381C>T synonymous_variant 0.28 ethionamide
isoniazid
mshA 575734 c.387T>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.26 ethionamide
isoniazid
mshA 575764 c.417C>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.24 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575786 p.Tyr147His missense_variant 0.21 ethionamide
isoniazid
mshA 575864 c.517T>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575878 c.531A>G synonymous_variant 0.24 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575902 c.555C>T synonymous_variant 0.2 ethionamide
isoniazid Not assoc w R - Interim
mshA 575908 c.561A>G synonymous_variant 0.19 ethionamide
isoniazid
mshA 575914 c.567C>G synonymous_variant 0.19 ethionamide
isoniazid
mshA 575916 p.Asp190Ala missense_variant 0.2 ethionamide
isoniazid
mshA 575925 p.Gly193Ala missense_variant 0.19 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.23 ethionamide
isoniazid
mshA 575953 c.606G>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575959 c.612G>A synonymous_variant 0.2 ethionamide
isoniazid
mshA 575980 c.633T>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575984 c.637T>C synonymous_variant 0.18 ethionamide
isoniazid
Rv0565c 657144 c.327T>C synonymous_variant 0.23 ethionamide
Rv0565c 657160 p.Glu104Arg missense_variant 0.24 ethionamide
Rv0565c 657187 p.His95Arg missense_variant 0.24 ethionamide
Rv0565c 657189 c.282C>G synonymous_variant 0.24 ethionamide
Rv0565c 657193 p.Met93Thr missense_variant 0.27 ethionamide
Rv0565c 657196 p.Asp92Ala missense_variant 0.26 ethionamide
Rv0565c 657199 p.Thr91Val missense_variant 0.27 ethionamide
Rv0565c 657201 c.270C>G synonymous_variant 0.27 ethionamide
Rv0565c 657220 p.Ala84Val missense_variant 0.28 ethionamide
Rv0565c 657233 p.Ile80Val missense_variant 0.29 ethionamide
Rv0565c 657240 c.229_231delGAAinsAG frameshift_variant&synonymous_variant 0.29 ethionamide Uncertain significance
Rv0565c 657243 c.228C>A synonymous_variant 0.31 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.34 ethionamide
Rv0565c 657261 c.210C>A synonymous_variant 0.33 ethionamide Not assoc w R - Interim
Rv0565c 657264 c.207T>C synonymous_variant 0.32 ethionamide
Rv0565c 657267 c.202_204delTCGinsCC frameshift_variant&synonymous_variant 0.35 ethionamide Uncertain significance
Rv0565c 657291 c.180C>G synonymous_variant 0.42 ethionamide
Rv0565c 657294 c.177C>T synonymous_variant 0.41 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.28 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.27 ethionamide
hadA 732370 c.441C>T synonymous_variant 0.18 isoniazid
hadA 732373 p.Glu148Asp missense_variant 0.2 isoniazid
hadA 732376 c.447T>C synonymous_variant 0.2 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.21 isoniazid
hadA 732391 c.462T>C synonymous_variant 0.19 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.19 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.18 isoniazid
nusG 734451 c.198G>C synonymous_variant 0.2 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.2 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.21 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.21 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734490 c.237C>T synonymous_variant 0.2 rifampicin Not assoc w R
nusG 734499 c.246G>C synonymous_variant 0.19 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.19 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.93 rifampicin Not assoc w R
rpoB 760223 c.417T>C synonymous_variant 0.17 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.3 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243His missense_variant 0.31 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 0.28 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 0.28 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.28 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.29 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.24 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.21 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.2 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.19 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.19 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.19 rifampicin
rpoB 760781 c.975G>C synonymous_variant 0.18 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.17 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.24 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.24 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.23 rifampicin
rpoB 761373 p.Val523His missense_variant 0.24 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.26 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.28 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.23 rifampicin
rpoB 761439 p.Asp545Ser missense_variant 0.23 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.23 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.23 rifampicin
rpoB 761452 p.Val549Glu missense_variant 0.23 rifampicin
rpoB 761457 p.Pro551Ser missense_variant 0.23 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.22 rifampicin
rpoB 761483 c.1677G>C synonymous_variant 0.24 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.27 rifampicin
rpoB 761504 c.1698C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.25 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.2 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.24 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.24 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.22 rifampicin
rpoB 761682 c.1876C>T synonymous_variant 0.21 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.23 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 0.24 rifampicin
rpoB 761720 c.1914C>G synonymous_variant 0.2 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.2 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.19 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.22 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.21 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.23 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.21 rifampicin
rpoB 761815 p.Ala670Asp missense_variant 0.17 rifampicin
rpoB 761819 c.2013G>C synonymous_variant 0.19 rifampicin
rpoB 761834 c.2028T>G synonymous_variant 0.2 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.2 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.2 rifampicin
rpoB 761873 c.2067A>G synonymous_variant 0.21 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.21 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.21 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.19 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.19 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.18 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.29 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.31 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.34 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.3 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.31 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.29 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762248 c.2442G>C synonymous_variant 0.3 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.32 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.33 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.35 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.31 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.3 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.29 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.29 rifampicin
rpoC 762389 c.-981G>A upstream_gene_variant 0.24 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.2 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.2 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.19 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.21 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.23 rifampicin
rpoC 762446 c.-924C>G upstream_gene_variant 0.23 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.29 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.35 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763142 c.-228C>G upstream_gene_variant 0.28 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.28 rifampicin
rpoC 763187 c.-183C>G upstream_gene_variant 0.26 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.19 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763253 c.-117G>C upstream_gene_variant 0.2 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.28 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.32 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.31 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.33 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.35 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.35 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.34 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.32 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.33 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763768 c.399C>G synonymous_variant 0.36 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.36 rifampicin
rpoC 763792 p.Glu141Asp missense_variant 0.38 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.35 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763813 c.444C>G synonymous_variant 0.34 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.33 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.37 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.37 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.42 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.39 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.4 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.39 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.4 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.38 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>G synonymous_variant 0.35 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.37 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.37 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.35 rifampicin
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.3 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.35 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.38 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.38 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.3 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.3 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764194 p.Glu275Asp missense_variant 0.36 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.37 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.36 rifampicin
rpoC 764245 c.876C>A synonymous_variant 0.39 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.39 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.39 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.38 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764344 c.975C>G synonymous_variant 0.33 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.28 rifampicin
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.25 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.33 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.29 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.29 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.29 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.31 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.24 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.28 rifampicin
rpoC 764585 c.1216_1218delCTCinsTG frameshift_variant&missense_variant 0.26 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.27 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>G synonymous_variant 0.27 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764815 c.1446A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.23 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.26 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.26 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765478 c.2109T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.27 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.35 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.35 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.38 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.38 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.43 rifampicin
rpoC 765752 p.Asp795Ser missense_variant 0.43 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.4 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.38 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.37 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.24 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.23 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766027 c.2658G>C synonymous_variant 0.23 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.22 rifampicin
rpoC 766054 c.2685C>T synonymous_variant 0.23 rifampicin
rpoC 766061 c.2692_2694delGTCinsCG frameshift_variant&missense_variant 0.23 rifampicin
rpoC 766081 c.2712T>C synonymous_variant 0.21 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.21 rifampicin
rpoC 766141 c.2772C>T synonymous_variant 0.16 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766456 c.3087C>G synonymous_variant 0.25 rifampicin
rpoC 766471 c.3102G>C synonymous_variant 0.24 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.25 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.24 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.24 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.2 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.2 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.2 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.17 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.17 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.17 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.22 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.24 rifampicin
rpoC 766633 c.3264G>C synonymous_variant 0.24 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.25 rifampicin
rpoC 766651 c.3282T>G synonymous_variant 0.25 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.23 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.23 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.23 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.22 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.23 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.23 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.27 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.25 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781655 c.96T>C synonymous_variant 0.18 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.18 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.22 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.23 streptomycin
rpsL 781706 c.147T>G synonymous_variant 0.28 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.28 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.28 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.29 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.3 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.32 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.33 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.33 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.33 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.29 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.29 streptomycin
rpsL 781820 c.261G>C synonymous_variant 0.3 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.29 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.3 streptomycin Not assoc w R - Interim
rpsL 781841 c.282C>G synonymous_variant 0.3 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.23 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.23 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.23 streptomycin
rpsL 781877 c.318T>G synonymous_variant 0.24 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.21 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.21 streptomycin Uncertain significance
rplC 800582 c.-227C>G upstream_gene_variant 0.21 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.19 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.19 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.2 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.22 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.22 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.21 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.24 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.24 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.24 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.24 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.25 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.23 linezolid
rplC 800793 c.-15_-11delAGATT upstream_gene_variant 0.24 linezolid
rplC 800803 c.-6A>C upstream_gene_variant 0.25 linezolid
rplC 800804 c.-4delA upstream_gene_variant 0.23 linezolid
rplC 800808 c.-1delAinsGAACTC upstream_gene_variant 0.23 linezolid
rplC 800815 c.7C>A synonymous_variant 0.23 linezolid
rplC 800820 c.12G>A synonymous_variant 0.23 linezolid
rplC 800829 c.21C>G synonymous_variant 0.23 linezolid
rplC 800844 c.36T>C synonymous_variant 0.22 linezolid
rplC 800856 c.48A>G synonymous_variant 0.23 linezolid
rplC 800865 c.57A>G synonymous_variant 0.21 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.21 linezolid
rplC 800872 c.64_66delAGAinsCG frameshift_variant&synonymous_variant 0.2 linezolid
rplC 800875 c.67_69delGTAinsAC frameshift_variant&missense_variant 0.19 linezolid
rplC 800880 c.72A>C synonymous_variant 0.19 linezolid
rplC 800889 c.81C>G synonymous_variant 0.2 linezolid
rplC 800901 c.93C>G synonymous_variant 0.22 linezolid
rplC 800916 c.108A>C synonymous_variant 0.2 linezolid
fbiC 1303812 c.882C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303842 c.912C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303851 c.921C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303869 c.939T>C synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303881 c.951G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303887 c.957G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303897 c.967C>T synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303905 c.975G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303908 c.978C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472094 n.249T>A non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474427 n.770A>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475387 n.1730C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475504 n.1847C>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid Uncertain significance
rrl 1475603 n.1946G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.25 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674331 c.130C>T synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674342 c.141T>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674352 p.Thr51Ala missense_variant 0.29 ethionamide Uncertain significance
isoniazid
inhA 1674368 p.Ala56Glu missense_variant 0.3 ethionamide
isoniazid
inhA 1674382 p.Leu61Ile missense_variant 0.35 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674729 c.528G>C synonymous_variant 0.36 ethionamide
isoniazid
inhA 1674750 c.549T>G synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674759 c.558G>C synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674771 c.570C>G synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674774 c.573A>G synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674780 c.579T>C synonymous_variant 0.38 ethionamide
isoniazid
rpsA 1833661 c.120A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833754 c.213G>A synonymous_variant 0.23 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.26 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833805 c.264C>T synonymous_variant 0.27 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.27 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.35 pyrazinamide
rpsA 1833871 c.330G>A synonymous_variant 0.29 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833895 c.354G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833949 c.408T>G synonymous_variant 0.23 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834102 c.561T>G synonymous_variant 0.18 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834222 c.681T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.39 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
rpsA 1834351 c.810G>A synonymous_variant 0.45 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.47 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.48 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834411 c.870T>G synonymous_variant 0.53 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.49 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.46 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.44 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.43 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.43 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.3 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.24 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.27 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.26 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.25 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.24 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.22 linezolid
tsnR 1853429 c.-177G>T upstream_gene_variant 0.23 linezolid
tsnR 1853444 c.-162C>G upstream_gene_variant 0.21 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.21 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.17 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517974 c.-141T>C upstream_gene_variant 0.17 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 0.85 isoniazid
kasA 2518444 c.330T>C synonymous_variant 0.18 isoniazid
kasA 2518447 c.333T>G synonymous_variant 0.18 isoniazid
kasA 2518459 c.345T>G synonymous_variant 0.22 isoniazid
kasA 2518462 c.348A>C synonymous_variant 0.24 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.26 isoniazid
kasA 2518475 c.361A>C synonymous_variant 0.29 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.29 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.35 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.36 isoniazid
kasA 2518513 c.399C>G synonymous_variant 0.38 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.38 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.42 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.41 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.4 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.41 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.42 isoniazid
kasA 2518579 c.465T>C synonymous_variant 0.41 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.43 isoniazid
kasA 2518594 c.480C>G synonymous_variant 0.42 isoniazid
kasA 2518597 c.483C>G synonymous_variant 0.41 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.45 isoniazid
kasA 2518639 c.525G>C synonymous_variant 0.43 isoniazid
kasA 2518657 c.543G>C synonymous_variant 0.38 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.38 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.42 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.45 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.42 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.38 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.42 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.41 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.41 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.38 isoniazid
Rv2477c 2783542 c.501G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2680 2996034 c.-71G>A upstream_gene_variant 0.23 capreomycin Uncertain significance
Rv2752c 3066075 c.117A>G synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066081 c.111G>C synonymous_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066087 c.105A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3066114 c.78A>G synonymous_variant 0.26 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066118 p.Asn25Ser missense_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066150 c.42C>T synonymous_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066228 c.-37T>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066237 c.-46C>G upstream_gene_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066260 c.-69T>C upstream_gene_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066264 c.-73C>T upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066276 c.-85G>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyA 3073977 c.495A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073980 c.492C>T synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073983 c.489C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.19 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.19 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074064 c.408C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074100 c.370_372delGATinsAC frameshift_variant&synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074103 c.369C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074121 p.Asp117Glu missense_variant 0.2 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074147 p.Ile109Val missense_variant 0.19 para-aminosalicylic_acid
thyA 3074154 c.318T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074165 p.Ala103Thr missense_variant 0.16 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624166 p.Met249Leu missense_variant 0.21 bedaquiline
rifampicin
lpqB 3624172 p.Val247Ile missense_variant 0.2 bedaquiline
rifampicin
lpqB 3624173 c.738A>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624200 c.711A>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624204 p.Ser236Asn missense_variant 0.19 bedaquiline
rifampicin
lpqB 3624209 c.702A>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624224 c.687T>C synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624233 c.678G>A synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624242 c.669A>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624245 c.666A>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624254 c.657T>C synonymous_variant 0.26 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624263 c.648T>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624266 c.645T>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624269 c.642G>C synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624276 p.Arg212His missense_variant 0.26 bedaquiline
rifampicin
lpqB 3624278 c.633G>C synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624290 c.621C>G synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624293 c.618A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624299 c.612G>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624304 p.Leu203Met missense_variant 0.18 bedaquiline
rifampicin
lpqB 3624319 p.Leu198Phe missense_variant 0.17 bedaquiline
rifampicin
lpqB 3624331 c.580C>T synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624335 c.576C>T synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624339 p.Arg191His missense_variant 0.19 bedaquiline
rifampicin
lpqB 3624341 c.570C>T synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624545 c.366T>C synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624556 p.Val119Met missense_variant 0.22 bedaquiline
rifampicin Uncertain significance
lpqB 3624557 c.354T>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624563 c.348C>A synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624569 c.342C>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624572 c.339C>G synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624575 c.336T>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624581 c.330A>C synonymous_variant 0.24 bedaquiline
rifampicin
lpqB 3624594 p.Val106Ala missense_variant 0.23 bedaquiline
rifampicin
lpqB 3624603 p.Lys103Arg missense_variant 0.23 bedaquiline
rifampicin
lpqB 3624605 c.306G>A synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624612 p.Ser100Ala missense_variant 0.23 bedaquiline
rifampicin
lpqB 3624614 c.297A>T synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624623 c.288C>G synonymous_variant 0.26 bedaquiline
rifampicin
lpqB 3624646 c.265T>C synonymous_variant 0.29 bedaquiline
rifampicin
lpqB 3624649 c.262T>C synonymous_variant 0.28 bedaquiline
rifampicin
lpqB 3624656 c.255C>T synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624659 c.252C>G synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624680 c.231T>G synonymous_variant 0.35 bedaquiline
rifampicin
lpqB 3624686 c.223_225delGAAinsCG frameshift_variant&missense_variant 0.35 bedaquiline
rifampicin Uncertain significance
lpqB 3624701 c.210T>G synonymous_variant 0.34 bedaquiline
rifampicin
lpqB 3624704 c.207G>C synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624707 c.204G>C synonymous_variant 0.32 bedaquiline
rifampicin
lpqB 3624710 c.201G>C synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624722 c.189C>G synonymous_variant 0.31 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624725 c.186G>C synonymous_variant 0.31 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.31 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625141 c.-231T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625147 c.-237C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.21 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625180 c.-270C>G upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625189 c.1425A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625195 c.-285A>G upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625198 c.-288C>G upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625204 c.1408_1410delTCGinsGC frameshift_variant&missense_variant 0.23 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625207 c.-297C>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625240 c.-330T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625243 c.-333T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625255 c.-345T>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625262 p.Tyr451Phe missense_variant 0.23 bedaquiline
rifampicin
mtrB 3625267 c.1347T>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625270 c.-360G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625285 c.-375G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625291 c.-381A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625297 c.-387C>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625301 p.Ala438Gly missense_variant 0.25 bedaquiline
rifampicin
mtrB 3625313 p.Arg434Gln missense_variant 0.22 bedaquiline
rifampicin
mtrB 3625321 c.1293A>G synonymous_variant 0.22 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625336 c.-426C>T upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625345 c.-435T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625351 c.1263T>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625354 c.-444G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625357 c.-447T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625381 c.-471T>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625384 c.1228_1230delGCGinsAC frameshift_variant&missense_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625387 c.-477T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625396 c.-486G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625407 p.Gln403Glu missense_variant 0.25 bedaquiline
rifampicin
mtrB 3625413 p.Ala401Thr missense_variant 0.27 bedaquiline
rifampicin
lpqB 3625420 c.-510T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625423 c.-513G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625431 c.-521T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625438 c.-528T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625444 p.Glu390Asp missense_variant 0.3 bedaquiline
rifampicin
lpqB 3625465 c.-555T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625471 c.-561C>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625478 p.Asn379Ser missense_variant 0.33 bedaquiline
rifampicin
mtrB 3625480 c.1132_1134delAACinsCA frameshift_variant&missense_variant 0.32 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625483 c.-573C>G upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625486 c.-576G>C upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625489 c.-579A>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3625497 c.1117T>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625501 c.-591C>G upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625510 c.-600T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625518 c.-608T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625531 c.-621C>G upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625540 c.-630G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.28 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625585 c.-675G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625588 c.-678G>A upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.27 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.28 bedaquiline
rifampicin
lpqB 3625621 c.-711G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625654 c.958_960delTTGinsCC frameshift_variant&missense_variant 0.24 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625663 c.-753G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625675 c.-765G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625729 c.885A>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.19 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.17 bedaquiline
rifampicin
lpqB 3625792 c.-882G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625864 c.-954T>G upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625909 c.-999T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3625912 c.702G>C synonymous_variant 0.2 bedaquiline
rifampicin
mtrB 3625915 c.699G>C synonymous_variant 0.21 bedaquiline
rifampicin
mtrB 3626048 p.Arg189Gln missense_variant 0.17 bedaquiline
rifampicin
mtrB 3626124 p.Ala164Ser missense_variant 0.18 bedaquiline
rifampicin
mtrB 3626125 c.489C>G synonymous_variant 0.19 bedaquiline
rifampicin
mtrB 3626146 c.468C>G synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3626157 p.Ala153Ser missense_variant 0.18 bedaquiline
rifampicin
mtrB 3626170 c.444T>C synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3626176 c.438C>G synonymous_variant 0.18 bedaquiline
rifampicin
mtrB 3626179 c.435A>T synonymous_variant 0.19 bedaquiline
rifampicin
mtrB 3626185 c.429T>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626188 c.424_426delTCTinsAG frameshift_variant&stop_gained 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626191 c.423C>G synonymous_variant 0.2 bedaquiline
rifampicin
mtrB 3626194 c.420T>G synonymous_variant 0.21 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626206 c.408T>C synonymous_variant 0.22 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626209 c.405T>C synonymous_variant 0.21 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626212 c.402G>C synonymous_variant 0.22 bedaquiline
rifampicin
mtrB 3626218 p.Met132Ile missense_variant 0.23 bedaquiline
rifampicin
mtrB 3626230 c.384T>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626239 c.375T>C synonymous_variant 0.25 bedaquiline
rifampicin
mtrB 3626840 c.-227C>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627191 c.-578G>A upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627196 c.-583C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627197 c.-584T>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627209 c.-596G>A upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627242 c.108C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627263 c.-650C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.16 bedaquiline
rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.23 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.25 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877803 c.705G>C synonymous_variant 0.28 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>G synonymous_variant 0.27 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.23 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877934 c.574C>T synonymous_variant 0.22 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877968 c.540C>G synonymous_variant 0.21 rifampicin
rpoA 3877974 c.534G>C synonymous_variant 0.2 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>G synonymous_variant 0.26 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.27 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.27 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>C synonymous_variant 0.26 rifampicin
rpoA 3878046 c.462T>A synonymous_variant 0.26 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.26 rifampicin
rpoA 3878067 c.441C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878070 c.438T>C synonymous_variant 0.23 rifampicin
rpoA 3878073 c.435C>T synonymous_variant 0.24 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878103 c.405A>G synonymous_variant 0.27 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.28 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.33 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.36 rifampicin
rpoA 3878142 p.Gly122Glu missense_variant 0.36 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.36 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878197 p.Glu104Ala missense_variant 0.37 rifampicin Uncertain significance
rpoA 3878199 c.309T>C synonymous_variant 0.38 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878264 p.Ser82Gly missense_variant 0.45 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.4 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878309 p.Pro67Ala missense_variant 0.39 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.39 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.44 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.38 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.38 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.38 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.42 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.42 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.42 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.41 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.43 rifampicin
rpoA 3878430 c.78G>C synonymous_variant 0.41 rifampicin
rpoA 3878433 c.75G>C synonymous_variant 0.41 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.41 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.41 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.42 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.39 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.39 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.24 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.26 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.31 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.36 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.39 rifampicin
rpoA 3878950 c.-443C>G upstream_gene_variant 0.42 rifampicin
rpoA 3878956 c.-449G>C upstream_gene_variant 0.44 rifampicin
rpoA 3878959 c.-452G>C upstream_gene_variant 0.44 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.44 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3878989 c.-482G>C upstream_gene_variant 0.37 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3879004 c.-499_-497delAAGinsCGC upstream_gene_variant 0.36 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.38 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.37 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.33 rifampicin
rpoA 3879079 c.-572A>C upstream_gene_variant 0.28 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.3 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.29 rifampicin
rpoA 3879115 c.-608G>A upstream_gene_variant 0.26 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.26 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.25 rifampicin
ddn 3986633 c.-211C>G upstream_gene_variant 0.2 delamanid
pretomanid
ddn 3986636 c.-208C>G upstream_gene_variant 0.19 delamanid
pretomanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.18 delamanid
pretomanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.16 delamanid
pretomanid
clpC1 4038347 c.2358G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.24 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.33 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.35 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.33 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.31 pyrazinamide
clpC1 4038461 c.2244G>T synonymous_variant 0.31 pyrazinamide
clpC1 4038474 p.Ser744Ala missense_variant 0.27 pyrazinamide
clpC1 4038486 p.Gly740Asn missense_variant 0.27 pyrazinamide
clpC1 4038489 p.Ala739Gly missense_variant 0.26 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.29 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.35 pyrazinamide
clpC1 4038533 p.Arg724Lys missense_variant 0.35 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.27 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.26 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.27 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038860 c.1845G>A synonymous_variant 0.17 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039043 c.1662G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039409 c.1296T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.41 pyrazinamide Uncertain significance
clpC1 4039582 p.Thr375Ser missense_variant 0.4 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.41 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.34 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.22 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.2 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040108 c.597G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040129 c.576C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040180 c.525C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040207 c.498T>C synonymous_variant 0.23 pyrazinamide
clpC1 4040213 c.492T>G synonymous_variant 0.22 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040231 c.474C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040234 c.471C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040240 c.465C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.25 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040393 c.312G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040431 c.274T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040462 c.243C>G synonymous_variant 0.22 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.21 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040480 c.225T>G synonymous_variant 0.23 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040534 c.171A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040537 c.168G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040567 c.138C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040570 c.135C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040594 c.111G>T synonymous_variant 0.18 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.18 pyrazinamide
clpC1 4040600 c.105A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.2 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.2 pyrazinamide
panD 4044725 c.-444C>T upstream_gene_variant 0.22 pyrazinamide
panD 4044737 c.-456T>G upstream_gene_variant 0.23 pyrazinamide
panD 4044755 c.-474G>C upstream_gene_variant 0.24 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.22 pyrazinamide
panD 4044785 c.-504C>G upstream_gene_variant 0.21 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.21 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.21 pyrazinamide
panD 4044806 c.-525T>C upstream_gene_variant 0.24 pyrazinamide
panD 4044812 c.-531A>G upstream_gene_variant 0.25 pyrazinamide
panD 4044815 c.-534G>A upstream_gene_variant 0.25 pyrazinamide
panD 4044821 c.-540C>T upstream_gene_variant 0.28 pyrazinamide
panD 4044833 c.-552A>C upstream_gene_variant 0.28 pyrazinamide
panD 4044839 c.-558C>G upstream_gene_variant 0.3 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.31 pyrazinamide
panD 4044854 c.-573A>G upstream_gene_variant 0.29 pyrazinamide
panD 4044872 c.-591C>T upstream_gene_variant 0.3 pyrazinamide
panD 4044881 c.-600T>C upstream_gene_variant 0.26 pyrazinamide
panD 4044893 c.-614_-612delACCinsGG upstream_gene_variant 0.23 pyrazinamide
panD 4044896 c.-615T>G upstream_gene_variant 0.23 pyrazinamide
panD 4044904 c.-623A>G upstream_gene_variant 0.24 pyrazinamide
panD 4044908 c.-628_-627delCTinsTG upstream_gene_variant 0.24 pyrazinamide
panD 4044917 c.-636G>C upstream_gene_variant 0.23 pyrazinamide
panD 4044929 c.-648G>C upstream_gene_variant 0.23 pyrazinamide
panD 4044935 c.-655_-654delAAinsTG upstream_gene_variant 0.21 pyrazinamide
panD 4044943 c.-662C>G upstream_gene_variant 0.18 pyrazinamide
panD 4044954 c.-673C>T upstream_gene_variant 0.21 pyrazinamide
panD 4044959 c.-678C>G upstream_gene_variant 0.19 pyrazinamide
panD 4044965 c.-684T>C upstream_gene_variant 0.18 pyrazinamide
glpK 4138606 c.1150T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138610 c.1146C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138634 c.1122G>A synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138670 c.1086G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138681 p.Met359Val missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138696 p.Pro354Ala missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239076 c.-787C>T upstream_gene_variant 0.21 ethambutol
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4240495 c.633T>C synonymous_variant 0.17 ethambutol
embC 4240514 p.Val218Met missense_variant 0.17 ethambutol
embC 4240543 c.681G>C synonymous_variant 0.19 ethambutol
embC 4240545 p.Pro228Gln missense_variant 0.19 ethambutol
embC 4240558 c.696C>G synonymous_variant 0.21 ethambutol
embC 4240561 c.699C>G synonymous_variant 0.21 ethambutol
embC 4240576 c.714A>G synonymous_variant 0.23 ethambutol
embC 4240578 p.Ala239Val missense_variant 0.22 ethambutol
embC 4240587 p.Gly242Ala missense_variant 0.22 ethambutol
embC 4240598 c.736_738delGTGinsAC frameshift_variant&missense_variant 0.22 ethambutol
embC 4240610 c.748_750delATCinsCG frameshift_variant&missense_variant 0.26 ethambutol
embC 4240615 c.753G>C synonymous_variant 0.26 ethambutol
embC 4240632 p.Met257Thr missense_variant 0.21 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.21 ethambutol
embC 4240654 c.792C>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4240655 p.Ala265Ser missense_variant 0.21 ethambutol
embC 4240670 p.Thr270Leu missense_variant 0.2 ethambutol
embC 4240673 p.Gly271Ser missense_variant 0.2 ethambutol
embC 4240678 c.816T>G synonymous_variant 0.2 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.21 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.19 ethambutol
embC 4240694 p.Ile278Val missense_variant 0.19 ethambutol
embC 4240729 c.867C>G synonymous_variant 0.18 ethambutol
embC 4240735 c.873C>G synonymous_variant 0.2 ethambutol
embC 4240822 c.960C>G synonymous_variant 0.19 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.2 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.29 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.33 ethambutol
embC 4240885 c.1023T>C synonymous_variant 0.33 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.35 ethambutol Not assoc w R
embC 4240898 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.35 ethambutol
embC 4240911 p.Ala350Val missense_variant 0.31 ethambutol
embC 4240924 c.1062C>G synonymous_variant 0.33 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.33 ethambutol
embC 4240945 c.1083T>C synonymous_variant 0.33 ethambutol
embC 4240951 c.1089C>G synonymous_variant 0.29 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.29 ethambutol
embC 4240957 c.1095C>G synonymous_variant 0.28 ethambutol
embC 4240960 c.1098G>C synonymous_variant 0.3 ethambutol
embC 4240978 c.1116G>A synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4240979 p.Thr373Gln missense_variant 0.24 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.24 ethambutol
embC 4240987 c.1125G>C synonymous_variant 0.24 ethambutol
embC 4240989 p.Ala376Gly missense_variant 0.23 ethambutol
embC 4241005 c.1143G>C synonymous_variant 0.26 ethambutol
embC 4241008 c.1146G>C synonymous_variant 0.26 ethambutol
embC 4241011 c.1149C>A synonymous_variant 0.27 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.26 ethambutol
embC 4241023 c.1161T>C synonymous_variant 0.27 ethambutol
embC 4241026 c.1164C>G synonymous_variant 0.29 ethambutol
embC 4241038 c.1176G>C synonymous_variant 0.28 ethambutol
embC 4241039 p.Asp393Asn missense_variant 0.28 ethambutol
embC 4241047 c.1185C>G synonymous_variant 0.28 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.29 ethambutol
embC 4241071 c.1209C>G synonymous_variant 0.26 ethambutol
embC 4241074 c.1212G>C synonymous_variant 0.24 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.24 ethambutol
embC 4241116 c.1254C>G synonymous_variant 0.24 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Ala missense_variant 0.24 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.21 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.2 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.9 ethambutol Not assoc w R
embA 4245674 c.2442A>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4249339 c.2826T>C synonymous_variant 0.27 ethambutol
embB 4249351 c.2838C>G synonymous_variant 0.29 ethambutol
embB 4249360 c.2847G>C synonymous_variant 0.32 ethambutol
embB 4249369 c.2856T>C synonymous_variant 0.33 ethambutol
embB 4249375 c.2862G>C synonymous_variant 0.32 ethambutol
embB 4249381 c.2868A>G synonymous_variant 0.32 ethambutol
embB 4249387 p.Glu958Asp missense_variant 0.32 ethambutol
embB 4249394 p.Ile961Val missense_variant 0.32 ethambutol
embB 4249399 c.2886G>C synonymous_variant 0.3 ethambutol
embB 4249400 p.Val963Leu missense_variant 0.3 ethambutol
embB 4249411 c.2898G>C synonymous_variant 0.26 ethambutol
embB 4249414 c.2901G>C synonymous_variant 0.25 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.25 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.27 ethambutol Uncertain significance
embB 4249432 c.2919A>G synonymous_variant 0.27 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4249465 c.2952G>C synonymous_variant 0.19 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.18 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.19 ethambutol
embB 4249487 c.2974T>C synonymous_variant 0.19 ethambutol
embB 4249492 c.2979C>A synonymous_variant 0.19 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin