Run ID: SRR1184298
Sample name:
Date: 2024-10-05T00:51:17.828878
Number of reads: 1109668
Percentage reads mapped: 65.34
Median coverage: 25.0
Strain: lineage4.3.3
Spoligotype:
Drug-resistance: Pre-XDR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4.3 | Euro-American (LAM) | None | 0.98 |
lineage4 | Euro-American | None | 0.99 |
lineage4.3.3 | Euro-American (LAM) | RD115 | 0.98 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | rpoB | p.Asp435Gly | Assoc w R - Interim | Expert rule: Non-silent variants in RRDR of rpoB |
p.Leu452Pro | Assoc w R | |||
isoniazid | inhA | c.-770T>A | Assoc w R - Interim | Alias fabG1_c.-8T>A. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) |
katG | p.Ser315Thr | Assoc w R | High-level resistance | |
ethambutol | embB | p.Met306Val | Assoc w R | |
pyrazinamide | pncA | c.456dupC | Assoc w R | |
streptomycin | rrs | n.462C>T | Uncertain significance | Mutation from literature |
gid | c.160_290del | Assoc w R | ||
fluoroquinolones | ||||
moxifloxacin | gyrA | p.Ala90Val | Assoc w R | Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) |
ofloxacin | ||||
levofloxacin | gyrA | p.Ala90Val | Assoc w R | |
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | rrs | n.1401A>G | Assoc w R | |
capreomycin | rrs | n.1401A>G | Assoc w R | |
kanamycin | rrs | n.1401A>G | Assoc w R | |
cycloserine | ||||
ethionamide | inhA | c.-770T>A | Assoc w R - Interim | Alias fabG1_c.-8T>A |
ethA | c.-11A>G | Uncertain significance | Mutation from literature | |
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
gyrA | 7570 | p.Ala90Val | missense_variant | 0.73 | levofloxacin | Assoc w R | |
moxifloxacin | Assoc w R | Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) | |||||
rpoB | 761110 | p.Asp435Gly | missense_variant | 0.69 | rifampicin | Assoc w R - Interim | Expert rule: Non-silent variants in RRDR of rpoB |
rpoB | 761161 | p.Leu452Pro | missense_variant | 0.65 | rifampicin | Assoc w R | |
rrs | 1472307 | n.462C>T | non_coding_transcript_exon_variant | 0.51 | streptomycin | Uncertain significance | Mutation from literature |
rrs | 1473246 | n.1401A>G | non_coding_transcript_exon_variant | 0.59 | amikacin | Assoc w R | |
capreomycin | Assoc w R | ||||||
kanamycin | Assoc w R | ||||||
inhA | 1673432 | c.-770T>A | upstream_gene_variant | 1.0 | ethionamide | Assoc w R - Interim | Alias fabG1_c.-8T>A |
isoniazid | Assoc w R - Interim | Alias fabG1_c.-8T>A. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) | |||||
katG | 2155168 | p.Ser315Thr | missense_variant | 1.0 | isoniazid | Assoc w R | High-level resistance |
pncA | 2288785 | c.456dupC | frameshift_variant | 0.92 | pyrazinamide | Assoc w R | |
embB | 4247429 | p.Met306Val | missense_variant | 0.89 | ethambutol | Assoc w R | |
ethA | 4327484 | c.-11A>G | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance | Mutation from literature |
gid | 4407912 | c.160_290del | frameshift_variant | 1.0 | streptomycin | Assoc w R |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
dnaA | 510 | c.510T>C | synonymous_variant | 0.17 | isoniazid | |
dnaA | 519 | c.519C>G | synonymous_variant | 0.18 | isoniazid | Not assoc w R |
dnaA | 558 | c.558G>C | synonymous_variant | 0.29 | isoniazid | |
dnaA | 561 | c.561C>T | synonymous_variant | 0.28 | isoniazid | |
dnaA | 567 | c.567C>G | synonymous_variant | 0.31 | isoniazid | |
dnaA | 571 | c.571T>C | synonymous_variant | 0.28 | isoniazid | |
dnaA | 582 | c.582A>C | synonymous_variant | 0.28 | isoniazid | Not assoc w R - Interim |
dnaA | 585 | c.585A>G | synonymous_variant | 0.26 | isoniazid | |
dnaA | 588 | c.588A>C | synonymous_variant | 0.27 | isoniazid | |
dnaA | 591 | c.591C>G | synonymous_variant | 0.28 | isoniazid | |
dnaA | 600 | c.600T>G | synonymous_variant | 0.3 | isoniazid | |
dnaA | 627 | c.627G>A | synonymous_variant | 0.26 | isoniazid | |
dnaA | 693 | c.693A>G | synonymous_variant | 0.24 | isoniazid | Not assoc w R - Interim |
dnaA | 705 | c.705A>G | synonymous_variant | 0.23 | isoniazid | |
dnaA | 708 | c.708T>C | synonymous_variant | 0.22 | isoniazid | |
dnaA | 741 | c.741T>C | synonymous_variant | 0.19 | isoniazid | Not assoc w R - Interim |
dnaA | 750 | c.750C>G | synonymous_variant | 0.2 | isoniazid | |
dnaA | 756 | c.756T>C | synonymous_variant | 0.2 | isoniazid | |
dnaA | 768 | c.768C>G | synonymous_variant | 0.18 | isoniazid | |
dnaA | 777 | c.777A>G | synonymous_variant | 0.19 | isoniazid | |
dnaA | 786 | c.786C>T | synonymous_variant | 0.15 | isoniazid | |
dnaA | 1220 | p.Asn407Ser | missense_variant | 0.37 | isoniazid | |
dnaA | 1230 | c.1230A>G | synonymous_variant | 0.36 | isoniazid | |
dnaA | 1236 | c.1236C>T | synonymous_variant | 0.36 | isoniazid | |
dnaA | 1242 | c.1242G>C | synonymous_variant | 0.38 | isoniazid | |
dnaA | 1245 | c.1245G>C | synonymous_variant | 0.41 | isoniazid | Not assoc w R - Interim |
dnaA | 1254 | c.1254T>C | synonymous_variant | 0.48 | isoniazid | |
dnaA | 1278 | c.1278T>C | synonymous_variant | 0.5 | isoniazid | |
dnaA | 1284 | c.1284C>G | synonymous_variant | 0.51 | isoniazid | |
dnaA | 1290 | c.1290G>A | synonymous_variant | 0.51 | isoniazid | |
dnaA | 1293 | c.1293T>C | synonymous_variant | 0.47 | isoniazid | |
dnaA | 1299 | c.1299G>C | synonymous_variant | 0.38 | isoniazid | Not assoc w R - Interim |
dnaA | 1302 | c.1302C>G | synonymous_variant | 0.37 | isoniazid | |
dnaA | 1311 | c.1311C>G | synonymous_variant | 0.32 | isoniazid | |
dnaA | 1314 | c.1314A>G | synonymous_variant | 0.31 | isoniazid | |
dnaA | 1317 | c.1317A>G | synonymous_variant | 0.29 | isoniazid | |
dnaA | 1320 | c.1320G>C | synonymous_variant | 0.29 | isoniazid | |
dnaA | 1332 | c.1332A>C | synonymous_variant | 0.32 | isoniazid | Not assoc w R - Interim |
dnaA | 1338 | c.1338T>C | synonymous_variant | 0.33 | isoniazid | |
dnaA | 1353 | c.1353T>C | synonymous_variant | 0.25 | isoniazid | |
dnaA | 1404 | c.1404T>C | synonymous_variant | 0.3 | isoniazid | |
dnaA | 1407 | c.1407T>C | synonymous_variant | 0.3 | isoniazid | |
dnaA | 1413 | c.1413A>C | synonymous_variant | 0.3 | isoniazid | |
dnaA | 1416 | c.1416C>G | synonymous_variant | 0.32 | isoniazid | |
dnaA | 1428 | c.1428C>G | synonymous_variant | 0.33 | isoniazid | |
dnaA | 1449 | c.1449G>A | synonymous_variant | 0.32 | isoniazid | |
gyrB | 6115 | c.876A>G | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6123 | p.Ala295Gly | missense_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6127 | c.888G>C | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6130 | c.891T>C | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6136 | c.897G>A | synonymous_variant | 0.19 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrB | 6139 | c.900G>C | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6196 | c.957C>T | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6238 | c.999G>A | synonymous_variant | 0.23 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6256 | c.1017G>A | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6268 | c.1029C>G | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6280 | c.1041T>C | synonymous_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6286 | c.1047T>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6289 | c.1050C>T | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6292 | c.1053G>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6307 | c.1068T>G | synonymous_variant | 0.27 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6319 | c.1080G>C | synonymous_variant | 0.27 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrB | 6346 | c.1107C>T | synonymous_variant | 0.36 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6362 | c.-940T>C | upstream_gene_variant | 0.31 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6376 | c.-926G>A | upstream_gene_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6379 | c.-923C>G | upstream_gene_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6382 | c.-920A>G | upstream_gene_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6388 | c.-914T>C | upstream_gene_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6403 | c.-899T>C | upstream_gene_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6518 | p.Val427Met | missense_variant | 0.95 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 6649 | c.-653T>C | upstream_gene_variant | 0.34 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6655 | c.-647T>C | upstream_gene_variant | 0.39 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6670 | c.-632G>C | upstream_gene_variant | 0.44 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6673 | c.-629A>C | upstream_gene_variant | 0.46 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6676 | c.-626T>G | upstream_gene_variant | 0.46 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6700 | c.-602T>C | upstream_gene_variant | 0.47 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6703 | c.-599G>C | upstream_gene_variant | 0.44 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6709 | c.-593A>G | upstream_gene_variant | 0.4 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6712 | c.-590G>C | upstream_gene_variant | 0.41 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6728 | c.-574_-572delCTAinsTTG | upstream_gene_variant | 0.41 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6742 | c.-560A>G | upstream_gene_variant | 0.35 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6745 | c.1506T>G | synonymous_variant | 0.34 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6751 | c.-551G>C | upstream_gene_variant | 0.31 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6841 | c.1602T>C | synonymous_variant | 0.25 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6844 | c.-458T>C | upstream_gene_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6853 | c.-449A>G | upstream_gene_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6856 | c.1617T>C | synonymous_variant | 0.27 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6859 | c.1620T>C | synonymous_variant | 0.28 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6862 | c.1623C>G | synonymous_variant | 0.28 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6868 | c.-434G>C | upstream_gene_variant | 0.3 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6877 | c.-425G>T | upstream_gene_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6878 | c.1639T>C | synonymous_variant | 0.25 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6881 | c.-421_-419delTTGinsCTC | upstream_gene_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6889 | c.-413G>T | upstream_gene_variant | 0.3 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6901 | c.-401G>C | upstream_gene_variant | 0.33 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6904 | c.-398C>G | upstream_gene_variant | 0.37 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6910 | c.-392G>A | upstream_gene_variant | 0.38 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6949 | c.-353A>G | upstream_gene_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6952 | c.1713C>G | synonymous_variant | 0.24 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6967 | c.-335T>C | upstream_gene_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6973 | c.-329G>C | upstream_gene_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6982 | c.-320A>C | upstream_gene_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7066 | c.-236G>C | upstream_gene_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7141 | c.-161T>C | upstream_gene_variant | 0.31 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7147 | c.-155G>C | upstream_gene_variant | 0.32 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7165 | c.-137C>G | upstream_gene_variant | 0.31 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7178 | c.-124T>C | upstream_gene_variant | 0.33 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7186 | c.1947C>G | synonymous_variant | 0.36 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 7216 | c.1977G>C | synonymous_variant | 0.29 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7412 | c.111C>G | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7427 | c.126G>C | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7532 | c.231T>G | synonymous_variant | 0.22 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7541 | c.240C>G | synonymous_variant | 0.2 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7547 | c.246C>T | synonymous_variant | 0.21 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 8040 | p.Gly247Ser | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 8111 | c.810G>C | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8121 | c.820T>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8129 | c.828T>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8135 | c.834C>G | synonymous_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8156 | c.855T>C | synonymous_variant | 0.35 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8168 | c.867A>G | synonymous_variant | 0.35 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8177 | c.876A>C | synonymous_variant | 0.34 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8198 | c.897T>C | synonymous_variant | 0.35 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8207 | c.906T>C | synonymous_variant | 0.34 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8219 | c.918T>C | synonymous_variant | 0.36 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8225 | c.924T>C | synonymous_variant | 0.37 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8234 | c.933T>C | synonymous_variant | 0.4 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8237 | c.936A>G | synonymous_variant | 0.38 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8247 | p.Ile316Val | missense_variant | 0.34 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8270 | c.969G>C | synonymous_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8276 | c.975G>A | synonymous_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8283 | p.Ile328Leu | missense_variant | 0.29 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 8288 | c.987T>C | synonymous_variant | 0.3 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8294 | c.993T>C | synonymous_variant | 0.31 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8324 | c.1023T>C | synonymous_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8597 | c.1296C>G | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8603 | c.1302A>G | synonymous_variant | 0.24 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8619 | c.1318_1320delTTGinsCTA | synonymous_variant | 0.3 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8624 | c.1323G>C | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8636 | c.1335A>C | synonymous_variant | 0.3 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8642 | c.1341A>G | synonymous_variant | 0.32 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8672 | c.1371A>G | synonymous_variant | 0.34 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8678 | c.1377G>A | synonymous_variant | 0.35 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8693 | c.1392T>C | synonymous_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8696 | c.1395G>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8699 | c.1398A>G | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8711 | c.1410A>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8714 | c.1413A>G | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8729 | c.1428T>C | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8730 | p.Gly477Arg | missense_variant | 0.18 | levofloxacin | Uncertain significance |
moxifloxacin | ||||||
gyrA | 9161 | c.1860C>G | synonymous_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9182 | c.1881T>C | synonymous_variant | 0.26 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9191 | c.1890G>C | synonymous_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9200 | c.1899A>G | synonymous_variant | 0.29 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9204 | p.Ser635Thr | missense_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9224 | c.1923C>T | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9230 | c.1929T>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9252 | p.Val651Ile | missense_variant | 0.31 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9674 | c.2373T>C | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
fgd1 | 490848 | c.66A>G | synonymous_variant | 0.38 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R - Interim | |||||
fgd1 | 490851 | c.69A>T | synonymous_variant | 0.38 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 490868 | p.Ala29Gly | missense_variant | 0.38 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 490887 | c.105G>A | synonymous_variant | 0.35 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 490890 | c.108C>G | synonymous_variant | 0.32 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 490905 | c.123T>C | synonymous_variant | 0.33 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491601 | c.819T>C | synonymous_variant | 0.27 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491610 | c.828A>G | synonymous_variant | 0.29 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491616 | c.834A>G | synonymous_variant | 0.23 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491620 | p.Ile280Val | missense_variant | 0.24 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491643 | c.861G>A | synonymous_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491646 | c.864G>C | synonymous_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491649 | c.867C>T | synonymous_variant | 0.24 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491658 | c.876A>G | synonymous_variant | 0.22 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
mshA | 575809 | c.462C>T | synonymous_variant | 0.27 | isoniazid | |
ethionamide | ||||||
mshA | 575812 | c.465C>T | synonymous_variant | 0.26 | isoniazid | |
ethionamide | ||||||
ccsA | 620340 | c.450C>G | synonymous_variant | 0.22 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620346 | c.456C>G | synonymous_variant | 0.27 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620362 | p.Ala158Thr | missense_variant | 0.32 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620367 | c.477T>C | synonymous_variant | 0.23 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620373 | c.483C>T | synonymous_variant | 0.23 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620376 | c.486G>C | synonymous_variant | 0.23 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
Rv0565c | 657632 | c.-162G>A | upstream_gene_variant | 0.25 | ethionamide | |
Rv0565c | 657649 | c.-179G>A | upstream_gene_variant | 0.27 | ethionamide | |
Rv0565c | 657671 | c.-201A>G | upstream_gene_variant | 0.26 | ethionamide | |
hadA | 731774 | c.-156T>C | upstream_gene_variant | 0.46 | isoniazid | |
hadA | 731789 | c.-141A>G | upstream_gene_variant | 0.46 | isoniazid | |
hadA | 731792 | c.-138G>A | upstream_gene_variant | 0.46 | isoniazid | |
hadA | 731801 | c.-129C>G | upstream_gene_variant | 0.32 | isoniazid | |
hadA | 731816 | c.-114G>A | upstream_gene_variant | 0.24 | isoniazid | |
hadA | 731840 | c.-90G>C | upstream_gene_variant | 0.18 | isoniazid | |
hadA | 731843 | c.-87T>C | upstream_gene_variant | 0.18 | isoniazid | |
hadA | 732295 | c.366G>C | synonymous_variant | 0.26 | isoniazid | |
hadA | 732305 | p.Ile126Val | missense_variant | 0.26 | isoniazid | |
hadA | 732308 | p.Val127Ile | missense_variant | 0.27 | isoniazid | |
hadA | 732378 | c.450_452dupAGA | disruptive_inframe_insertion | 0.29 | isoniazid | |
hadA | 732396 | p.Gly156Ala | missense_variant | 0.28 | isoniazid | |
hadA | 732398 | p.Ala157Thr | missense_variant | 0.27 | isoniazid | |
nusG | 734407 | p.Val52Ile | missense_variant | 0.27 | rifampicin | |
nusG | 734421 | c.168A>G | synonymous_variant | 0.32 | rifampicin | |
nusG | 734424 | c.171G>A | synonymous_variant | 0.32 | rifampicin | |
nusG | 734442 | c.189G>A | synonymous_variant | 0.39 | rifampicin | |
nusG | 734451 | c.198G>C | synonymous_variant | 0.38 | rifampicin | |
nusG | 734457 | c.204C>G | synonymous_variant | 0.38 | rifampicin | |
nusG | 734472 | c.219T>C | synonymous_variant | 0.35 | rifampicin | |
nusG | 734475 | c.222T>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
nusG | 734499 | c.246G>C | synonymous_variant | 0.41 | rifampicin | |
nusG | 734532 | c.279A>G | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
nusG | 734541 | c.288A>G | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
nusG | 734826 | c.573A>C | synonymous_variant | 0.32 | rifampicin | |
nusG | 734829 | c.576C>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
nusG | 734841 | c.588G>C | synonymous_variant | 0.29 | rifampicin | |
nusG | 734847 | c.594T>C | synonymous_variant | 0.26 | rifampicin | |
nusG | 734850 | c.597C>G | synonymous_variant | 0.26 | rifampicin | |
nusG | 734853 | c.600A>G | synonymous_variant | 0.26 | rifampicin | |
nusG | 734854 | c.601T>C | synonymous_variant | 0.26 | rifampicin | |
nusG | 734882 | p.Ala210Gly | missense_variant | 0.23 | rifampicin | |
nusG | 734886 | c.633A>G | synonymous_variant | 0.24 | rifampicin | |
rpoB | 760060 | p.Tyr85Leu | missense_variant | 0.25 | rifampicin | |
rpoB | 760067 | c.261G>C | synonymous_variant | 0.27 | rifampicin | |
rpoB | 760070 | c.264T>G | synonymous_variant | 0.26 | rifampicin | |
rpoB | 760091 | c.285G>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 760101 | c.295T>C | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 760112 | c.306T>C | synonymous_variant | 0.4 | rifampicin | |
rpoB | 760118 | c.312T>G | synonymous_variant | 0.44 | rifampicin | Not assoc w R - Interim |
rpoB | 760121 | c.315T>C | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoB | 760130 | p.Asp108Glu | missense_variant | 0.52 | rifampicin | Uncertain significance |
rpoB | 760139 | c.333A>G | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoB | 760142 | c.336C>G | synonymous_variant | 0.52 | rifampicin | |
rpoB | 760181 | c.375T>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 760184 | c.378A>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 760196 | c.390C>G | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoB | 760223 | c.417T>C | synonymous_variant | 0.4 | rifampicin | |
rpoB | 760235 | c.429T>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoB | 760283 | c.477G>C | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoB | 760298 | c.492G>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoB | 760307 | c.501T>C | synonymous_variant | 0.4 | rifampicin | |
rpoB | 760310 | c.504G>C | synonymous_variant | 0.4 | rifampicin | |
rpoB | 760328 | c.522G>C | synonymous_variant | 0.36 | rifampicin | |
rpoB | 760361 | c.555T>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoB | 760370 | c.564C>G | synonymous_variant | 0.36 | rifampicin | |
rpoB | 760376 | p.Asp190Glu | missense_variant | 0.36 | rifampicin | Uncertain significance |
rpoB | 760380 | p.Thr192Leu | missense_variant | 0.38 | rifampicin | |
rpoB | 760406 | c.600G>C | synonymous_variant | 0.43 | rifampicin | |
rpoB | 760412 | c.606C>G | synonymous_variant | 0.42 | rifampicin | |
rpoB | 760424 | c.618C>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoB | 760430 | c.624T>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoB | 760472 | c.666C>T | synonymous_variant | 0.35 | rifampicin | |
rpoB | 760475 | c.669A>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 760591 | p.Val262Ala | missense_variant | 0.32 | rifampicin | |
rpoB | 760611 | c.805T>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 760646 | c.840C>G | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoB | 760655 | c.849A>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 760661 | c.855A>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 760670 | c.864G>C | synonymous_variant | 0.27 | rifampicin | |
rpoB | 760674 | c.868T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 760679 | c.873A>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 760683 | c.877T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 760715 | c.909C>G | synonymous_variant | 0.22 | rifampicin | |
rpoB | 760718 | c.912C>T | synonymous_variant | 0.23 | rifampicin | |
rpoB | 760886 | c.1080A>G | synonymous_variant | 0.23 | rifampicin | |
rpoB | 760925 | c.1119T>C | synonymous_variant | 0.28 | rifampicin | |
rpoB | 760928 | c.1122G>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 760931 | c.1125C>G | synonymous_variant | 0.25 | rifampicin | |
rpoB | 760934 | c.1128C>T | synonymous_variant | 0.27 | rifampicin | |
rpoB | 760946 | c.1140A>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 760982 | c.1176G>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoB | 760985 | c.1179G>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoB | 760991 | c.1185G>C | synonymous_variant | 0.4 | rifampicin | |
rpoB | 761006 | c.1200C>G | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoB | 761015 | c.1209G>C | synonymous_variant | 0.46 | rifampicin | Not assoc w R - Interim |
rpoB | 761021 | c.1215G>C | synonymous_variant | 0.46 | rifampicin | |
rpoB | 761027 | c.1221A>G | synonymous_variant | 0.46 | rifampicin | Not assoc w R - Interim |
rpoB | 761036 | c.1230G>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoB | 761037 | c.1231T>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoB | 761057 | c.1251G>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 761102 | c.1296A>G | synonymous_variant | 0.29 | rifampicin | |
rpoB | 761129 | c.1323G>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 761132 | c.1326G>T | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 761133 | c.1327T>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 761150 | c.1344A>C | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoB | 761153 | c.1347G>C | synonymous_variant | 0.33 | rifampicin | |
rpoB | 761165 | c.1359G>C | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoB | 761180 | c.1374A>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 761189 | c.1383T>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 761195 | c.1389G>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoB | 761207 | c.1401C>T | synonymous_variant | 0.36 | rifampicin | |
rpoB | 761213 | c.1407G>C | synonymous_variant | 0.38 | rifampicin | |
rpoB | 761219 | c.1413G>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 761249 | c.1443A>G | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoB | 761255 | c.1449T>G | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoB | 761261 | c.1455G>T | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoB | 761306 | c.1500C>G | synonymous_variant | 0.38 | rifampicin | |
rpoB | 761327 | c.1521A>G | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoB | 761330 | c.1524G>C | synonymous_variant | 0.42 | rifampicin | |
rpoB | 761354 | c.1548C>T | synonymous_variant | 0.33 | rifampicin | |
rpoB | 761477 | c.1671C>G | synonymous_variant | 0.32 | rifampicin | |
rpoB | 761765 | c.1959T>C | synonymous_variant | 0.38 | rifampicin | |
rpoB | 761772 | p.His656Ala | missense_variant | 0.37 | rifampicin | |
rpoB | 761778 | p.Asn658Asp | missense_variant | 0.35 | rifampicin | |
rpoB | 761791 | p.Arg662His | missense_variant | 0.31 | rifampicin | |
rpoB | 761813 | c.2007T>C | synonymous_variant | 0.41 | rifampicin | |
rpoB | 761815 | p.Ala670Glu | missense_variant | 0.37 | rifampicin | |
rpoB | 761834 | c.2028T>C | synonymous_variant | 0.33 | rifampicin | |
rpoB | 761852 | c.2046C>G | synonymous_variant | 0.21 | rifampicin | |
rpoB | 761858 | c.2052G>C | synonymous_variant | 0.22 | rifampicin | |
rpoB | 761873 | c.2067A>C | synonymous_variant | 0.26 | rifampicin | |
rpoB | 761954 | c.2148C>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 762008 | c.2202C>T | synonymous_variant | 0.49 | rifampicin | Not assoc w R - Interim |
rpoB | 762014 | c.2208C>T | synonymous_variant | 0.44 | rifampicin | |
rpoB | 762017 | c.2211A>G | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoB | 762053 | c.2247T>C | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoB | 762062 | c.2256T>C | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 762065 | c.2259T>C | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 762083 | c.2277T>C | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 762086 | c.2280G>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoB | 762101 | c.2295C>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 762114 | p.Ile770Val | missense_variant | 0.34 | rifampicin | Uncertain significance |
rpoB | 762149 | c.2343G>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 762167 | c.2361T>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 762176 | c.2370T>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 762185 | c.2379G>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 762206 | c.2400C>G | synonymous_variant | 0.34 | rifampicin | |
rpoB | 762233 | c.2427G>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 762266 | c.2460T>C | synonymous_variant | 0.26 | rifampicin | |
rpoB | 762284 | c.2478G>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 762293 | c.2487T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoB | 762314 | c.2508C>T | synonymous_variant | 0.24 | rifampicin | |
rpoB | 762317 | c.2511A>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 762329 | c.2523G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 762338 | c.2532T>C | synonymous_variant | 0.26 | rifampicin | |
rpoC | 762434 | c.-936T>C | upstream_gene_variant | 0.34 | rifampicin | |
rpoB | 762449 | c.2643C>A | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoC | 762467 | c.-903C>T | upstream_gene_variant | 0.38 | rifampicin | |
rpoB | 762827 | c.3021G>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoB | 762857 | c.3051C>G | synonymous_variant | 0.52 | rifampicin | Not assoc w R - Interim |
rpoB | 762860 | c.3054G>C | synonymous_variant | 0.52 | rifampicin | Not assoc w R - Interim |
rpoB | 762863 | c.3057T>C | synonymous_variant | 0.52 | rifampicin | Not assoc w R - Interim |
rpoB | 762929 | c.3123G>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 762989 | c.-381G>C | upstream_gene_variant | 0.33 | rifampicin | |
rpoB | 762995 | c.3189G>T | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoC | 763013 | c.-357C>G | upstream_gene_variant | 0.44 | rifampicin | |
rpoB | 763028 | c.3222T>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 763034 | c.3228C>G | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoB | 763040 | c.3234C>G | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 763067 | c.-303C>G | upstream_gene_variant | 0.35 | rifampicin | |
rpoB | 763070 | c.3264T>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoB | 763085 | c.3279C>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoB | 763115 | c.3309T>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoB | 763123 | p.Ile1106Thr | missense_variant | 0.68 | rifampicin | Uncertain significance |
rpoB | 763136 | c.3330C>T | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 763158 | c.-212C>T | upstream_gene_variant | 0.28 | rifampicin | |
rpoB | 763166 | c.3360A>G | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 763402 | c.33C>G | synonymous_variant | 0.22 | rifampicin | |
rpoC | 763411 | c.42T>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 763414 | c.45T>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 763441 | c.72C>T | synonymous_variant | 0.27 | rifampicin | |
rpoC | 763444 | c.75T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 763456 | c.87A>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 763486 | c.117T>G | synonymous_variant | 0.43 | rifampicin | |
rpoC | 763492 | c.123G>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 763528 | c.159G>A | synonymous_variant | 0.49 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.49 | rifampicin | Not assoc w R - Interim |
rpoC | 763570 | c.201G>C | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoC | 763573 | c.204G>C | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoC | 763594 | c.225C>T | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoC | 763603 | c.234C>T | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoC | 763606 | c.237C>T | synonymous_variant | 0.39 | rifampicin | |
rpoC | 763636 | c.267T>C | synonymous_variant | 0.36 | rifampicin | |
rpoC | 763657 | c.288G>A | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoC | 763660 | c.291T>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoC | 763675 | c.306C>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoC | 763696 | c.327T>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoC | 763702 | c.333C>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoC | 763717 | c.348T>C | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 763723 | c.354G>C | synonymous_variant | 0.39 | rifampicin | |
rpoC | 763732 | c.363C>G | synonymous_variant | 0.41 | rifampicin | |
rpoC | 763741 | c.372C>T | synonymous_variant | 0.39 | rifampicin | |
rpoC | 763744 | c.375G>C | synonymous_variant | 0.39 | rifampicin | |
rpoC | 763765 | c.396T>C | synonymous_variant | 0.36 | rifampicin | |
rpoC | 763774 | c.405G>C | synonymous_variant | 0.38 | rifampicin | |
rpoC | 763807 | c.438T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 763816 | c.447C>G | synonymous_variant | 0.34 | rifampicin | |
rpoC | 763835 | p.Ala156Met | missense_variant | 0.39 | rifampicin | |
rpoC | 763853 | p.Val162Ile | missense_variant | 0.46 | rifampicin | |
rpoC | 763858 | c.489A>G | synonymous_variant | 0.48 | rifampicin | |
rpoC | 763872 | p.Gly168Ala | missense_variant | 0.4 | rifampicin | |
rpoC | 763876 | p.Glu169Asp | missense_variant | 0.42 | rifampicin | |
rpoC | 763879 | c.510A>G | synonymous_variant | 0.42 | rifampicin | |
rpoC | 763915 | c.546C>T | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 764059 | c.690G>T | synonymous_variant | 0.29 | rifampicin | |
rpoC | 764236 | c.867G>A | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 764248 | c.879C>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 764257 | c.888G>C | synonymous_variant | 0.38 | rifampicin | |
rpoC | 764266 | c.897T>C | synonymous_variant | 0.33 | rifampicin | |
rpoC | 764269 | c.900G>C | synonymous_variant | 0.33 | rifampicin | |
rpoC | 764272 | c.903G>C | synonymous_variant | 0.38 | rifampicin | |
rpoC | 764278 | c.909A>G | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 764338 | c.969G>A | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 764446 | c.1077T>C | synonymous_variant | 0.23 | rifampicin | |
rpoC | 764449 | c.1080G>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764452 | c.1083T>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764458 | c.1089G>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 764461 | c.1092A>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 764489 | c.1120C>T | synonymous_variant | 0.23 | rifampicin | |
rpoC | 764497 | c.1128A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 764752 | c.1383G>C | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoC | 764764 | c.1395T>C | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoC | 764809 | c.1440C>T | synonymous_variant | 0.37 | rifampicin | Not assoc w R |
rpoC | 764815 | c.1446A>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 764827 | c.1458G>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 764858 | c.1489T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 764872 | c.1503A>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 764888 | c.1519T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 764911 | c.1542A>G | synonymous_variant | 0.36 | rifampicin | |
rpoC | 764932 | c.1563C>A | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 764948 | c.1579T>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 764968 | c.1599T>C | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoC | 764995 | c.1626C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
rpoC | 765055 | c.1686C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 765292 | c.1923G>C | synonymous_variant | 0.29 | rifampicin | |
rpoC | 765298 | c.1929G>C | synonymous_variant | 0.3 | rifampicin | |
rpoC | 765300 | p.Val644Ala | missense_variant | 0.3 | rifampicin | Uncertain significance |
rpoC | 765319 | c.1950A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 765326 | p.His653Ala | missense_variant | 0.21 | rifampicin | Uncertain significance |
rpoC | 765330 | p.Ser654Asn | missense_variant | 0.21 | rifampicin | Uncertain significance |
rpoC | 765346 | c.1977C>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 765349 | c.1980T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765352 | c.1983G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 765364 | c.1995G>A | synonymous_variant | 0.17 | rifampicin | |
rpoC | 765383 | p.Met672Leu | missense_variant | 0.22 | rifampicin | Uncertain significance |
rpoC | 765404 | p.Leu679Val | missense_variant | 0.24 | rifampicin | |
rpoC | 765409 | c.2040T>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 765421 | c.2052C>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 765478 | c.2109T>C | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoC | 765499 | c.2130C>G | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 765529 | c.2160C>T | synonymous_variant | 0.44 | rifampicin | |
rpoC | 765541 | c.2172C>G | synonymous_variant | 0.41 | rifampicin | |
rpoC | 765553 | c.2184C>T | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoC | 765556 | c.2187G>C | synonymous_variant | 0.41 | rifampicin | |
rpoC | 765559 | c.2190G>C | synonymous_variant | 0.44 | rifampicin | |
rpoC | 765580 | c.2211G>C | synonymous_variant | 0.51 | rifampicin | |
rpoC | 765613 | p.His748Gln | missense_variant | 0.41 | rifampicin | |
rpoC | 765625 | c.2256C>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 765628 | c.2259G>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 765631 | p.Asp754Glu | missense_variant | 0.29 | rifampicin | |
rpoC | 765700 | c.2331T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 765734 | c.2365T>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 765739 | c.2370G>T | synonymous_variant | 0.39 | rifampicin | |
rpoC | 765751 | c.2382C>G | synonymous_variant | 0.33 | rifampicin | |
rpoC | 765753 | p.Asp795Ala | missense_variant | 0.33 | rifampicin | Uncertain significance |
rpoC | 765772 | c.2403C>G | synonymous_variant | 0.47 | rifampicin | |
rpoC | 765784 | c.2415C>G | synonymous_variant | 0.44 | rifampicin | |
rpoC | 765787 | c.2418C>T | synonymous_variant | 0.44 | rifampicin | |
rpoC | 765793 | c.2424C>G | synonymous_variant | 0.44 | rifampicin | |
rpoC | 765796 | c.2427C>T | synonymous_variant | 0.46 | rifampicin | |
rpoC | 765811 | c.2442T>C | synonymous_variant | 0.52 | rifampicin | Not assoc w R - Interim |
rpoC | 765814 | c.2445A>G | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoC | 765826 | c.2457T>C | synonymous_variant | 0.52 | rifampicin | Not assoc w R - Interim |
rpoC | 765835 | c.2466C>T | synonymous_variant | 0.52 | rifampicin | Not assoc w R - Interim |
rpoC | 765850 | c.2481G>C | synonymous_variant | 0.54 | rifampicin | Not assoc w R - Interim |
rpoC | 765883 | c.2514C>G | synonymous_variant | 0.53 | rifampicin | |
rpoC | 765886 | c.2517C>G | synonymous_variant | 0.53 | rifampicin | |
rpoC | 765892 | c.2523T>C | synonymous_variant | 0.55 | rifampicin | Not assoc w R - Interim |
rpoC | 765937 | c.2568T>C | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoC | 765967 | c.2598C>T | synonymous_variant | 0.53 | rifampicin | Not assoc w R - Interim |
rpoC | 765982 | c.2613C>G | synonymous_variant | 0.47 | rifampicin | |
rpoC | 765994 | c.2625A>T | synonymous_variant | 0.46 | rifampicin | Not assoc w R - Interim |
rpoC | 766010 | c.2641_2642delTCinsAG | synonymous_variant | 0.5 | rifampicin | |
rpoC | 766021 | c.2652G>C | synonymous_variant | 0.67 | rifampicin | |
rpoC | 766027 | c.2658G>C | synonymous_variant | 0.64 | rifampicin | |
rpoC | 766043 | p.Gln892Glu | missense_variant | 0.64 | rifampicin | |
rpoC | 766054 | c.2685C>G | synonymous_variant | 0.59 | rifampicin | |
rpoC | 766082 | p.Ala905Gln | missense_variant | 0.58 | rifampicin | |
rpoC | 766096 | c.2727G>C | synonymous_variant | 0.56 | rifampicin | |
rpoC | 766381 | c.3012C>T | synonymous_variant | 0.32 | rifampicin | |
rpoC | 766384 | c.3015A>G | synonymous_variant | 0.32 | rifampicin | |
rpoC | 766390 | c.3021C>T | synonymous_variant | 0.39 | rifampicin | |
rpoC | 766393 | c.3024C>G | synonymous_variant | 0.39 | rifampicin | |
rpoC | 766408 | c.3039C>G | synonymous_variant | 0.43 | rifampicin | |
rpoC | 766411 | c.3042C>G | synonymous_variant | 0.43 | rifampicin | |
rpoC | 766426 | c.3057C>T | synonymous_variant | 0.45 | rifampicin | |
rpoC | 766447 | c.3078T>C | synonymous_variant | 0.45 | rifampicin | |
rpoC | 766462 | c.3093G>C | synonymous_variant | 0.37 | rifampicin | |
rpoC | 766607 | p.Ile1080Leu | missense_variant | 0.22 | rifampicin | |
rpoC | 766630 | c.3261G>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 766657 | c.3288A>G | synonymous_variant | 0.26 | rifampicin | |
rpoC | 766672 | c.3303T>C | synonymous_variant | 0.29 | rifampicin | |
rpoC | 766673 | p.Gly1102Asn | missense_variant | 0.29 | rifampicin | |
rpoC | 766726 | c.3357T>C | synonymous_variant | 0.41 | rifampicin | |
rpoC | 766738 | c.3369G>C | synonymous_variant | 0.38 | rifampicin | |
rpoC | 766765 | c.3396A>C | synonymous_variant | 0.52 | rifampicin | Not assoc w R - Interim |
rpoC | 766774 | c.3405T>C | synonymous_variant | 0.49 | rifampicin | |
rpoC | 766795 | c.3426C>T | synonymous_variant | 0.39 | rifampicin | |
rpoC | 766801 | c.3432C>G | synonymous_variant | 0.38 | rifampicin | |
rpoC | 766804 | c.3435A>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 766861 | c.3492G>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 766864 | c.3495G>C | synonymous_variant | 0.27 | rifampicin | |
rpoC | 766900 | c.3531T>C | synonymous_variant | 0.44 | rifampicin | |
rpoC | 766933 | c.3564A>G | synonymous_variant | 0.38 | rifampicin | |
rpoC | 766945 | c.3576A>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 766963 | c.3594T>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 766972 | c.3603G>C | synonymous_variant | 0.38 | rifampicin | |
rpoC | 767059 | c.3690T>G | synonymous_variant | 0.48 | rifampicin | Not assoc w R - Interim |
rpoC | 767062 | c.3693C>A | synonymous_variant | 0.52 | rifampicin | |
rpoC | 767098 | c.3729T>C | synonymous_variant | 0.7 | rifampicin | Not assoc w R - Interim |
rpoC | 767119 | c.3750A>G | synonymous_variant | 0.66 | rifampicin | Not assoc w R - Interim |
rpoC | 767134 | c.3765C>A | synonymous_variant | 0.67 | rifampicin | |
rpoC | 767158 | c.3789T>C | synonymous_variant | 0.65 | rifampicin | Not assoc w R - Interim |
rpoC | 767180 | p.Ala1271Gln | missense_variant | 0.48 | rifampicin | |
rpoC | 767191 | c.3822C>G | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoC | 767206 | c.3837C>G | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoC | 767209 | c.3840T>C | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
rpoC | 767212 | c.3843G>C | synonymous_variant | 0.46 | rifampicin | |
rpoC | 767221 | c.3852C>G | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoC | 767230 | c.3861G>C | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoC | 767233 | c.3864T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
mmpL5 | 775975 | c.2506T>C | synonymous_variant | 0.28 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 775981 | p.Leu834Met | missense_variant | 0.3 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777191 | c.1290C>G | synonymous_variant | 0.19 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 777194 | c.1287A>G | synonymous_variant | 0.19 | bedaquiline | |
clofazimine | ||||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781628 | c.69T>C | synonymous_variant | 0.41 | streptomycin | Not assoc w R - Interim |
rpsL | 781631 | c.72G>C | synonymous_variant | 0.42 | streptomycin | |
rpsL | 781649 | c.90T>C | synonymous_variant | 0.48 | streptomycin | |
rpsL | 781655 | c.96T>C | synonymous_variant | 0.5 | streptomycin | |
rpsL | 781700 | c.141G>C | synonymous_variant | 0.45 | streptomycin | |
rpsL | 781703 | c.144G>T | synonymous_variant | 0.45 | streptomycin | |
rpsL | 781715 | c.156T>C | synonymous_variant | 0.42 | streptomycin | |
rpsL | 781728 | c.169T>C | synonymous_variant | 0.34 | streptomycin | |
rpsL | 781736 | c.177T>C | synonymous_variant | 0.39 | streptomycin | |
rpsL | 781742 | c.183C>T | synonymous_variant | 0.4 | streptomycin | |
rpsL | 781748 | c.189C>G | synonymous_variant | 0.43 | streptomycin | |
rpsL | 781754 | c.195G>C | synonymous_variant | 0.41 | streptomycin | |
rpsL | 781760 | c.201T>C | synonymous_variant | 0.39 | streptomycin | |
rpsL | 781772 | c.213C>A | synonymous_variant | 0.38 | streptomycin | |
rpsL | 781808 | c.249C>T | synonymous_variant | 0.35 | streptomycin | |
rpsL | 781811 | c.252C>T | synonymous_variant | 0.4 | streptomycin | |
rpsL | 781832 | c.273T>C | synonymous_variant | 0.47 | streptomycin | |
rpsL | 781838 | c.279G>C | synonymous_variant | 0.4 | streptomycin | |
rpsL | 781841 | c.282C>G | synonymous_variant | 0.39 | streptomycin | |
rpsL | 781865 | c.306G>C | synonymous_variant | 0.35 | streptomycin | |
rpsL | 781868 | c.309T>C | synonymous_variant | 0.36 | streptomycin | |
rpsL | 781871 | c.312G>C | synonymous_variant | 0.39 | streptomycin | |
rpsL | 781877 | c.318T>C | synonymous_variant | 0.4 | streptomycin | |
rpsL | 781892 | c.333A>G | synonymous_variant | 0.39 | streptomycin | |
rpsL | 781898 | c.339A>T | synonymous_variant | 0.41 | streptomycin | |
rpsL | 781916 | c.357T>C | synonymous_variant | 0.48 | streptomycin | |
rpsL | 781929 | p.Gly124Ser | missense_variant | 0.55 | streptomycin | Uncertain significance |
rplC | 800516 | c.-293G>T | upstream_gene_variant | 0.23 | linezolid | |
rplC | 800537 | c.-272C>T | upstream_gene_variant | 0.29 | linezolid | |
rplC | 800540 | c.-269T>C | upstream_gene_variant | 0.29 | linezolid | |
rplC | 800546 | c.-263T>G | upstream_gene_variant | 0.27 | linezolid | |
rplC | 800567 | c.-242A>G | upstream_gene_variant | 0.26 | linezolid | |
rplC | 800618 | c.-191T>C | upstream_gene_variant | 0.26 | linezolid | |
rplC | 800627 | c.-182C>T | upstream_gene_variant | 0.26 | linezolid | |
rplC | 800648 | c.-161A>T | upstream_gene_variant | 0.38 | linezolid | |
rplC | 800654 | c.-155T>C | upstream_gene_variant | 0.34 | linezolid | |
rplC | 800693 | c.-116A>G | upstream_gene_variant | 0.41 | linezolid | |
rplC | 800703 | c.-106T>C | upstream_gene_variant | 0.38 | linezolid | |
rplC | 800715 | c.-94A>C | upstream_gene_variant | 0.39 | linezolid | |
rplC | 800720 | c.-89T>C | upstream_gene_variant | 0.33 | linezolid | |
rplC | 800723 | c.-86C>G | upstream_gene_variant | 0.32 | linezolid | |
rplC | 800747 | c.-62C>G | upstream_gene_variant | 0.27 | linezolid | |
rplC | 800771 | c.-38C>T | upstream_gene_variant | 0.32 | linezolid | |
rplC | 800794 | c.-15A>G | upstream_gene_variant | 0.24 | linezolid | |
rplC | 800796 | c.-13A>G | upstream_gene_variant | 0.23 | linezolid | |
rplC | 800798 | c.-10_-9delGG | upstream_gene_variant | 0.24 | linezolid | |
rplC | 800814 | c.6A>G | synonymous_variant | 0.33 | linezolid | |
rplC | 800817 | c.9A>T | synonymous_variant | 0.31 | linezolid | |
rplC | 800844 | c.36T>C | synonymous_variant | 0.27 | linezolid | |
rplC | 800889 | c.81C>G | synonymous_variant | 0.18 | linezolid | |
rplC | 800892 | c.84G>C | synonymous_variant | 0.18 | linezolid | |
rplC | 801147 | c.339T>C | synonymous_variant | 0.2 | linezolid | |
rplC | 801150 | c.342G>C | synonymous_variant | 0.22 | linezolid | |
rplC | 801153 | c.345G>C | synonymous_variant | 0.24 | linezolid | |
rplC | 801156 | c.348T>A | synonymous_variant | 0.29 | linezolid | |
rplC | 801168 | c.360C>G | synonymous_variant | 0.37 | linezolid | |
rplC | 801171 | c.363A>G | synonymous_variant | 0.37 | linezolid | |
rplC | 801174 | c.366T>C | synonymous_variant | 0.37 | linezolid | |
rplC | 801180 | c.372C>G | synonymous_variant | 0.43 | linezolid | |
rplC | 801195 | c.387G>C | synonymous_variant | 0.45 | linezolid | |
rplC | 801207 | c.399C>T | synonymous_variant | 0.5 | linezolid | |
rplC | 801300 | c.492C>G | synonymous_variant | 0.38 | linezolid | |
rplC | 801357 | c.549T>C | synonymous_variant | 0.34 | linezolid | |
rplC | 801367 | p.Ala187Thr | missense_variant | 0.4 | linezolid | |
fbiC | 1303530 | c.600G>A | synonymous_variant | 0.31 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303534 | p.Ser202Ala | missense_variant | 0.32 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303539 | c.609G>C | synonymous_variant | 0.34 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303545 | c.615A>G | synonymous_variant | 0.4 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303575 | c.645G>C | synonymous_variant | 0.39 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303590 | c.660A>G | synonymous_variant | 0.35 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303836 | c.906G>C | synonymous_variant | 0.29 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303845 | c.915C>G | synonymous_variant | 0.32 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303846 | p.Phe306Val | missense_variant | 0.32 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303854 | c.924T>C | synonymous_variant | 0.32 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303860 | c.930A>C | synonymous_variant | 0.32 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303884 | c.954T>G | synonymous_variant | 0.35 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303905 | c.975G>C | synonymous_variant | 0.35 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303909 | p.Pro327Ser | missense_variant | 0.36 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303914 | c.984C>G | synonymous_variant | 0.34 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303920 | c.990C>T | synonymous_variant | 0.38 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303944 | c.1014G>C | synonymous_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303947 | c.1017T>G | synonymous_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303948 | p.Gly340Arg | missense_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303953 | p.Asp341Glu | missense_variant | 0.27 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303954 | p.Glu342Gln | missense_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303961 | p.Arg344Leu | missense_variant | 0.27 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303971 | c.1041T>C | synonymous_variant | 0.26 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303980 | c.1050G>A | synonymous_variant | 0.27 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304553 | c.1623C>T | synonymous_variant | 0.34 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304559 | p.Glu543Asp | missense_variant | 0.34 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304565 | c.1635C>G | synonymous_variant | 0.3 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304568 | c.1638T>C | synonymous_variant | 0.3 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304580 | c.1650T>C | synonymous_variant | 0.33 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304613 | c.1683T>C | synonymous_variant | 0.31 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304634 | c.1704C>G | synonymous_variant | 0.24 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304640 | c.1710A>C | synonymous_variant | 0.23 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304646 | c.1716T>C | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304742 | c.1812T>C | synonymous_variant | 0.3 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304748 | c.1818T>C | synonymous_variant | 0.31 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304757 | c.1827A>G | synonymous_variant | 0.35 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304778 | c.1848T>C | synonymous_variant | 0.31 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304784 | c.1854T>C | synonymous_variant | 0.31 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304787 | c.1857T>G | synonymous_variant | 0.31 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304808 | c.1878C>G | synonymous_variant | 0.33 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304811 | c.1881C>G | synonymous_variant | 0.35 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304817 | c.1887T>C | synonymous_variant | 0.41 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304829 | c.1899T>C | synonymous_variant | 0.45 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304832 | c.1902C>T | synonymous_variant | 0.45 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R - Interim | |||||
fbiC | 1304853 | c.1923C>T | synonymous_variant | 0.35 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304856 | c.1926C>G | synonymous_variant | 0.32 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304869 | c.1939C>T | synonymous_variant | 0.41 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304875 | p.Ile649Val | missense_variant | 0.46 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304883 | p.Glu651Asp | missense_variant | 0.48 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304891 | p.Ile654Thr | missense_variant | 0.41 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304893 | p.Gly655Ser | missense_variant | 0.41 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304907 | c.1977C>G | synonymous_variant | 0.38 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304910 | c.1980G>C | synonymous_variant | 0.36 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304916 | c.1986T>C | synonymous_variant | 0.34 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304928 | c.1998T>C | synonymous_variant | 0.35 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304937 | c.2007G>C | synonymous_variant | 0.44 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304958 | c.2028T>G | synonymous_variant | 0.5 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304983 | c.2053C>T | synonymous_variant | 0.46 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304994 | c.2064A>G | synonymous_variant | 0.46 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304995 | p.Leu689Met | missense_variant | 0.46 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305006 | c.2076A>G | synonymous_variant | 0.45 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305012 | c.2082G>C | synonymous_variant | 0.39 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305015 | c.2085G>C | synonymous_variant | 0.39 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1305021 | c.2091C>G | synonymous_variant | 0.4 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
sigE | 1364898 | c.486C>T | synonymous_variant | 0.47 | pyrazinamide | |
sigE | 1364904 | p.Asp164Glu | missense_variant | 0.47 | pyrazinamide | |
sigE | 1364919 | c.507T>C | synonymous_variant | 0.23 | pyrazinamide | |
atpE | 1460882 | c.-163T>C | upstream_gene_variant | 0.27 | bedaquiline | |
atpE | 1460894 | c.-151A>G | upstream_gene_variant | 0.25 | bedaquiline | |
atpE | 1460897 | c.-148A>C | upstream_gene_variant | 0.25 | bedaquiline | |
atpE | 1460900 | c.-145T>C | upstream_gene_variant | 0.26 | bedaquiline | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471923 | n.78T>C | non_coding_transcript_exon_variant | 0.44 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471925 | n.80T>C | non_coding_transcript_exon_variant | 0.44 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1471932 | n.87A>G | non_coding_transcript_exon_variant | 0.45 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471934 | n.89A>G | non_coding_transcript_exon_variant | 0.44 | kanamycin | |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471969 | n.124T>C | non_coding_transcript_exon_variant | 0.36 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1471970 | n.125G>A | non_coding_transcript_exon_variant | 0.36 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472044 | n.199G>T | non_coding_transcript_exon_variant | 0.21 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472045 | n.200T>A | non_coding_transcript_exon_variant | 0.2 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472053 | n.211_212delGC | non_coding_transcript_exon_variant | 0.24 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472061 | n.216A>T | non_coding_transcript_exon_variant | 0.27 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472075 | n.230A>G | non_coding_transcript_exon_variant | 0.4 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472108 | n.263C>T | non_coding_transcript_exon_variant | 0.51 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472969 | n.1124A>G | non_coding_transcript_exon_variant | 0.42 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472970 | n.1125C>G | non_coding_transcript_exon_variant | 0.43 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472977 | n.1132G>C | non_coding_transcript_exon_variant | 0.44 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472978 | n.1133T>C | non_coding_transcript_exon_variant | 0.44 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473105 | n.1260G>A | non_coding_transcript_exon_variant | 0.39 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473123 | n.1278delAinsTT | non_coding_transcript_exon_variant | 0.33 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473145 | n.1300C>T | non_coding_transcript_exon_variant | 0.33 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473166 | n.1321G>A | non_coding_transcript_exon_variant | 0.34 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473290 | n.1445C>T | non_coding_transcript_exon_variant | 0.4 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrl | 1473668 | n.11C>T | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473677 | n.20C>G | non_coding_transcript_exon_variant | 0.3 | capreomycin | |
linezolid | ||||||
rrl | 1473756 | n.99G>A | non_coding_transcript_exon_variant | 0.56 | capreomycin | |
linezolid | ||||||
rrl | 1473758 | n.101G>T | non_coding_transcript_exon_variant | 0.54 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473877 | n.220G>A | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1473898 | n.241C>T | non_coding_transcript_exon_variant | 0.35 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473943 | n.286G>T | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473945 | n.288T>A | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473946 | n.289A>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473986 | n.329T>C | non_coding_transcript_exon_variant | 0.35 | capreomycin | |
linezolid | ||||||
rrl | 1473987 | n.330G>A | non_coding_transcript_exon_variant | 0.35 | capreomycin | |
linezolid | ||||||
rrl | 1473995 | n.338G>T | non_coding_transcript_exon_variant | 0.39 | capreomycin | |
linezolid | ||||||
rrl | 1474001 | n.344C>T | non_coding_transcript_exon_variant | 0.41 | capreomycin | Not assoc w R |
linezolid | Not assoc w R | |||||
rrl | 1474009 | n.352A>G | non_coding_transcript_exon_variant | 0.44 | capreomycin | |
linezolid | ||||||
rrl | 1474012 | n.355C>T | non_coding_transcript_exon_variant | 0.43 | capreomycin | |
linezolid | ||||||
rrl | 1474093 | n.436G>T | non_coding_transcript_exon_variant | 0.37 | capreomycin | |
linezolid | ||||||
rrl | 1474099 | n.442G>A | non_coding_transcript_exon_variant | 0.36 | capreomycin | |
linezolid | ||||||
rrl | 1474103 | n.446A>T | non_coding_transcript_exon_variant | 0.35 | capreomycin | |
linezolid | ||||||
rrl | 1474140 | n.483C>T | non_coding_transcript_exon_variant | 0.46 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474151 | n.494C>T | non_coding_transcript_exon_variant | 0.5 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474181 | n.524C>T | non_coding_transcript_exon_variant | 0.54 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474249 | n.592G>T | non_coding_transcript_exon_variant | 0.49 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474291 | n.635_649delTTCCTCTCCGGAGGA | non_coding_transcript_exon_variant | 0.45 | capreomycin | |
linezolid | ||||||
rrl | 1474308 | n.651G>T | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474310 | n.653T>G | non_coding_transcript_exon_variant | 0.38 | capreomycin | |
linezolid | ||||||
rrl | 1474356 | n.699T>C | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474362 | n.705A>G | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474376 | n.719T>C | non_coding_transcript_exon_variant | 0.24 | capreomycin | |
linezolid | ||||||
rrl | 1474639 | n.982G>A | non_coding_transcript_exon_variant | 0.44 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.45 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474823 | n.1166C>T | non_coding_transcript_exon_variant | 0.41 | capreomycin | |
linezolid | ||||||
rrl | 1474831 | n.1174A>G | non_coding_transcript_exon_variant | 0.4 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474904 | n.1247G>A | non_coding_transcript_exon_variant | 0.37 | capreomycin | |
linezolid | ||||||
rrl | 1475006 | n.1349A>T | non_coding_transcript_exon_variant | 0.35 | capreomycin | |
linezolid | ||||||
rrl | 1475088 | n.1431A>T | non_coding_transcript_exon_variant | 0.5 | capreomycin | |
linezolid | ||||||
rrl | 1475199 | n.1542G>A | non_coding_transcript_exon_variant | 0.38 | capreomycin | |
linezolid | ||||||
rrl | 1475206 | n.1549C>T | non_coding_transcript_exon_variant | 0.38 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475209 | n.1552G>C | non_coding_transcript_exon_variant | 0.4 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475213 | n.1556C>T | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475249 | n.1592T>C | non_coding_transcript_exon_variant | 0.45 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475252 | n.1595C>T | non_coding_transcript_exon_variant | 0.49 | capreomycin | |
linezolid | ||||||
rrl | 1475266 | n.1609T>C | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475267 | n.1610G>A | non_coding_transcript_exon_variant | 0.49 | capreomycin | |
linezolid | ||||||
rrl | 1475275 | n.1618C>T | non_coding_transcript_exon_variant | 0.51 | capreomycin | |
linezolid | ||||||
rrl | 1475276 | n.1619T>C | non_coding_transcript_exon_variant | 0.51 | capreomycin | |
linezolid | ||||||
rrl | 1475291 | n.1634A>C | non_coding_transcript_exon_variant | 0.51 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475313 | n.1656G>A | non_coding_transcript_exon_variant | 0.53 | capreomycin | |
linezolid | ||||||
rrl | 1475315 | n.1658A>T | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475355 | n.1698C>T | non_coding_transcript_exon_variant | 0.44 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475369 | n.1712G>T | non_coding_transcript_exon_variant | 0.42 | capreomycin | |
linezolid | ||||||
rrl | 1475402 | n.1745C>T | non_coding_transcript_exon_variant | 0.39 | capreomycin | |
linezolid | ||||||
rrl | 1475419 | n.1762C>T | non_coding_transcript_exon_variant | 0.38 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475429 | n.1772G>A | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475436 | n.1779C>T | non_coding_transcript_exon_variant | 0.43 | capreomycin | |
linezolid | ||||||
rrl | 1475483 | n.1826C>T | non_coding_transcript_exon_variant | 0.4 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475505 | n.1848G>A | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.31 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475599 | n.1942A>G | non_coding_transcript_exon_variant | 0.44 | capreomycin | |
linezolid | Uncertain significance | |||||
rrl | 1475608 | n.1951T>C | non_coding_transcript_exon_variant | 0.48 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475642 | n.1985T>C | non_coding_transcript_exon_variant | 0.5 | capreomycin | |
linezolid | ||||||
rrl | 1475657 | n.2000A>G | non_coding_transcript_exon_variant | 0.5 | capreomycin | |
linezolid | ||||||
rrl | 1475659 | n.2002G>T | non_coding_transcript_exon_variant | 0.5 | capreomycin | |
linezolid | ||||||
rrl | 1475761 | n.2104_2106delCGCinsGT | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1475765 | n.2111delG | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1475881 | n.2224T>C | non_coding_transcript_exon_variant | 0.4 | capreomycin | |
linezolid | ||||||
rrl | 1475988 | n.2331A>G | non_coding_transcript_exon_variant | 0.34 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476031 | n.2374C>T | non_coding_transcript_exon_variant | 0.38 | capreomycin | |
linezolid | ||||||
rrl | 1476033 | n.2376T>C | non_coding_transcript_exon_variant | 0.35 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476034 | n.2377C>A | non_coding_transcript_exon_variant | 0.35 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476045 | n.2388G>T | non_coding_transcript_exon_variant | 0.34 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476047 | n.2390G>T | non_coding_transcript_exon_variant | 0.36 | capreomycin | |
linezolid | ||||||
rrl | 1476048 | n.2391G>A | non_coding_transcript_exon_variant | 0.36 | capreomycin | |
linezolid | ||||||
rrl | 1476049 | n.2392C>T | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476056 | n.2399G>A | non_coding_transcript_exon_variant | 0.61 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476086 | n.2429G>A | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476089 | n.2432T>C | non_coding_transcript_exon_variant | 0.32 | capreomycin | |
linezolid | ||||||
rrl | 1476095 | n.2438C>G | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1476115 | n.2458T>C | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476117 | n.2460G>C | non_coding_transcript_exon_variant | 0.27 | capreomycin | |
linezolid | ||||||
rrl | 1476214 | n.2557G>A | non_coding_transcript_exon_variant | 0.35 | capreomycin | |
linezolid | ||||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.31 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476583 | n.2926G>A | non_coding_transcript_exon_variant | 0.34 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476584 | n.2927C>T | non_coding_transcript_exon_variant | 0.35 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476594 | n.2937C>T | non_coding_transcript_exon_variant | 0.36 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.36 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476603 | n.2946G>A | non_coding_transcript_exon_variant | 0.35 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476608 | n.2951C>G | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.36 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476689 | n.3032A>T | non_coding_transcript_exon_variant | 0.34 | capreomycin | |
linezolid | ||||||
rrl | 1476690 | n.3033C>T | non_coding_transcript_exon_variant | 0.34 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476693 | n.3036G>A | non_coding_transcript_exon_variant | 0.34 | capreomycin | |
linezolid | ||||||
rrl | 1476695 | n.3038T>A | non_coding_transcript_exon_variant | 0.34 | capreomycin | |
linezolid | ||||||
rrl | 1476716 | n.3059A>C | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476726 | n.3069A>G | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
inhA | 1673710 | c.-492C>A | upstream_gene_variant | 0.2 | isoniazid | |
ethionamide | ||||||
inhA | 1673716 | c.-486_-485delGCinsAA | upstream_gene_variant | 0.2 | isoniazid | |
ethionamide | ||||||
inhA | 1673905 | c.-297T>G | upstream_gene_variant | 0.18 | isoniazid | |
ethionamide | ||||||
inhA | 1673916 | c.-286A>C | upstream_gene_variant | 0.27 | isoniazid | |
ethionamide | ||||||
inhA | 1673917 | c.-285G>C | upstream_gene_variant | 0.27 | isoniazid | |
ethionamide | ||||||
inhA | 1673922 | c.-280T>C | upstream_gene_variant | 0.29 | isoniazid | |
ethionamide | ||||||
inhA | 1673941 | c.-261G>T | upstream_gene_variant | 0.29 | isoniazid | |
ethionamide | ||||||
inhA | 1673946 | c.-256C>G | upstream_gene_variant | 0.31 | isoniazid | |
ethionamide | ||||||
inhA | 1673955 | c.-247G>C | upstream_gene_variant | 0.26 | isoniazid | |
ethionamide | ||||||
inhA | 1673961 | c.-241A>C | upstream_gene_variant | 0.28 | isoniazid | |
ethionamide | ||||||
inhA | 1673985 | c.-217C>G | upstream_gene_variant | 0.28 | isoniazid | |
ethionamide | ||||||
inhA | 1674537 | c.336C>G | synonymous_variant | 0.32 | isoniazid | |
ethionamide | ||||||
inhA | 1674542 | p.Ala114Glu | missense_variant | 0.31 | isoniazid | |
ethionamide | ||||||
inhA | 1674546 | c.345T>C | synonymous_variant | 0.29 | isoniazid | |
ethionamide | ||||||
inhA | 1674549 | c.348G>C | synonymous_variant | 0.29 | isoniazid | |
ethionamide | ||||||
inhA | 1674552 | c.351C>G | synonymous_variant | 0.29 | isoniazid | |
ethionamide | ||||||
inhA | 1674555 | c.354G>A | synonymous_variant | 0.31 | isoniazid | Not assoc w R - Interim |
ethionamide | Not assoc w R - Interim | |||||
inhA | 1674561 | c.360C>T | synonymous_variant | 0.38 | isoniazid | |
ethionamide | ||||||
inhA | 1674582 | c.381T>C | synonymous_variant | 0.4 | isoniazid | |
ethionamide | ||||||
inhA | 1674585 | c.384T>C | synonymous_variant | 0.4 | isoniazid | |
ethionamide | ||||||
inhA | 1674589 | p.Met130Leu | missense_variant | 0.4 | isoniazid | |
ethionamide | ||||||
inhA | 1674597 | c.396G>A | synonymous_variant | 0.4 | isoniazid | |
ethionamide | ||||||
inhA | 1674601 | p.Leu134Thr | missense_variant | 0.39 | isoniazid | |
ethionamide | ||||||
inhA | 1674624 | c.423A>C | synonymous_variant | 0.49 | isoniazid | |
ethionamide | ||||||
inhA | 1674630 | c.429C>G | synonymous_variant | 0.39 | isoniazid | |
ethionamide | ||||||
inhA | 1674660 | c.459G>C | synonymous_variant | 0.47 | isoniazid | |
ethionamide | ||||||
inhA | 1674672 | c.471C>G | synonymous_variant | 0.37 | isoniazid | |
ethionamide | ||||||
inhA | 1674703 | c.502T>C | synonymous_variant | 0.37 | isoniazid | |
ethionamide | ||||||
inhA | 1674708 | c.507G>A | synonymous_variant | 0.29 | isoniazid | |
ethionamide | ||||||
inhA | 1674718 | c.517A>C | synonymous_variant | 0.28 | isoniazid | |
ethionamide | ||||||
inhA | 1674726 | c.525G>A | synonymous_variant | 0.28 | isoniazid | |
ethionamide | ||||||
inhA | 1674822 | c.621C>G | synonymous_variant | 0.31 | isoniazid | |
ethionamide | ||||||
inhA | 1674828 | c.627G>A | synonymous_variant | 0.35 | isoniazid | |
ethionamide | ||||||
inhA | 1674846 | p.Ile215Met | missense_variant | 0.43 | isoniazid | |
ethionamide | ||||||
rpsA | 1833589 | c.48A>T | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1833595 | c.54T>C | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1833661 | c.120A>G | synonymous_variant | 0.36 | pyrazinamide | |
rpsA | 1833667 | c.126C>G | synonymous_variant | 0.37 | pyrazinamide | |
rpsA | 1833721 | c.180A>G | synonymous_variant | 0.52 | pyrazinamide | |
rpsA | 1833724 | c.183C>G | synonymous_variant | 0.5 | pyrazinamide | |
rpsA | 1833727 | c.186G>C | synonymous_variant | 0.52 | pyrazinamide | |
rpsA | 1833742 | c.201A>G | synonymous_variant | 0.52 | pyrazinamide | |
rpsA | 1833745 | c.204G>C | synonymous_variant | 0.52 | pyrazinamide | |
rpsA | 1833748 | c.207C>G | synonymous_variant | 0.5 | pyrazinamide | |
rpsA | 1833787 | c.246C>G | synonymous_variant | 0.45 | pyrazinamide | |
rpsA | 1833790 | c.249T>C | synonymous_variant | 0.48 | pyrazinamide | |
rpsA | 1833802 | c.261A>G | synonymous_variant | 0.48 | pyrazinamide | |
rpsA | 1833811 | c.270G>T | synonymous_variant | 0.49 | pyrazinamide | |
rpsA | 1833838 | c.297G>C | synonymous_variant | 0.52 | pyrazinamide | |
rpsA | 1833841 | c.300C>G | synonymous_variant | 0.52 | pyrazinamide | |
rpsA | 1833847 | c.306C>G | synonymous_variant | 0.54 | pyrazinamide | |
rpsA | 1833856 | c.315A>G | synonymous_variant | 0.51 | pyrazinamide | |
rpsA | 1833874 | c.333T>C | synonymous_variant | 0.52 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.55 | pyrazinamide | |
rpsA | 1833940 | c.399C>G | synonymous_variant | 0.53 | pyrazinamide | |
rpsA | 1833971 | c.430C>T | synonymous_variant | 0.59 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.62 | pyrazinamide | |
rpsA | 1834000 | c.459G>C | synonymous_variant | 0.53 | pyrazinamide | |
rpsA | 1834021 | c.480C>T | synonymous_variant | 0.48 | pyrazinamide | |
rpsA | 1834030 | c.489C>G | synonymous_variant | 0.43 | pyrazinamide | |
rpsA | 1834210 | c.669C>T | synonymous_variant | 0.32 | pyrazinamide | |
rpsA | 1834249 | c.708T>C | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1834261 | c.720A>G | synonymous_variant | 0.38 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834264 | c.723G>C | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1834303 | c.762T>C | synonymous_variant | 0.36 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 0.35 | pyrazinamide | |
rpsA | 1834348 | c.807T>C | synonymous_variant | 0.37 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.35 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834378 | c.837T>C | synonymous_variant | 0.37 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834396 | c.855G>C | synonymous_variant | 0.4 | pyrazinamide | |
rpsA | 1834411 | c.870T>C | synonymous_variant | 0.36 | pyrazinamide | |
rpsA | 1834417 | c.876G>C | synonymous_variant | 0.35 | pyrazinamide | |
rpsA | 1834435 | c.894G>C | synonymous_variant | 0.42 | pyrazinamide | |
rpsA | 1834451 | c.910T>C | synonymous_variant | 0.41 | pyrazinamide | |
rpsA | 1834465 | c.924T>C | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1834489 | c.948T>C | synonymous_variant | 0.46 | pyrazinamide | |
rpsA | 1834510 | c.969C>T | synonymous_variant | 0.45 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834513 | c.972C>G | synonymous_variant | 0.44 | pyrazinamide | |
rpsA | 1834528 | c.987T>C | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1834540 | c.999G>C | synonymous_variant | 0.44 | pyrazinamide | |
rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.44 | pyrazinamide | |
rpsA | 1834609 | c.1068T>C | synonymous_variant | 0.42 | pyrazinamide | |
rpsA | 1834633 | c.1092A>G | synonymous_variant | 0.44 | pyrazinamide | |
rpsA | 1834639 | c.1098T>C | synonymous_variant | 0.4 | pyrazinamide | |
rpsA | 1834654 | p.Glu371Asp | missense_variant | 0.38 | pyrazinamide | |
rpsA | 1834684 | c.1143C>T | synonymous_variant | 0.53 | pyrazinamide | |
rpsA | 1834690 | c.1149T>C | synonymous_variant | 0.53 | pyrazinamide | |
rpsA | 1834732 | c.1191T>C | synonymous_variant | 0.34 | pyrazinamide | |
rpsA | 1834733 | p.Ala398Ser | missense_variant | 0.34 | pyrazinamide | |
rpsA | 1834738 | c.1197A>G | synonymous_variant | 0.35 | pyrazinamide | |
rpsA | 1834753 | c.1212T>C | synonymous_variant | 0.39 | pyrazinamide | |
rpsA | 1834765 | p.Glu408Asp | missense_variant | 0.35 | pyrazinamide | |
rpsA | 1834775 | p.Ala412Thr | missense_variant | 0.31 | pyrazinamide | |
rpsA | 1834780 | c.1239A>G | synonymous_variant | 0.3 | pyrazinamide | |
tlyA | 1917951 | c.12T>C | synonymous_variant | 0.3 | capreomycin | |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
tlyA | 1917975 | c.36C>G | synonymous_variant | 0.35 | capreomycin | |
tlyA | 1917981 | c.42G>C | synonymous_variant | 0.35 | capreomycin | |
tlyA | 1917990 | c.51G>C | synonymous_variant | 0.39 | capreomycin | |
tlyA | 1917993 | c.54A>G | synonymous_variant | 0.39 | capreomycin | Not assoc w R - Interim |
tlyA | 1917996 | c.57A>G | synonymous_variant | 0.37 | capreomycin | |
tlyA | 1918002 | c.63A>G | synonymous_variant | 0.39 | capreomycin | |
bacA | 2064972 | c.-244T>C | upstream_gene_variant | 0.64 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
bacA | 2064978 | c.-250G>C | upstream_gene_variant | 0.55 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
bacA | 2064979 | c.-251C>T | upstream_gene_variant | 0.55 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
bacA | 2064984 | c.-256A>G | upstream_gene_variant | 0.58 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
bacA | 2064993 | c.-265T>C | upstream_gene_variant | 0.5 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
ndh | 2102671 | c.372T>G | synonymous_variant | 0.24 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102680 | c.363T>C | synonymous_variant | 0.27 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102686 | c.357G>C | synonymous_variant | 0.26 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102695 | c.348C>T | synonymous_variant | 0.23 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102700 | c.343C>T | synonymous_variant | 0.23 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102710 | c.333C>T | synonymous_variant | 0.26 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
Rv1979c | 2223051 | p.Glu38Asp | missense_variant | 1.0 | bedaquiline | Uncertain significance |
clofazimine | Uncertain significance | |||||
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
kasA | 2518190 | p.Ser26Ala | missense_variant | 0.26 | isoniazid | |
kasA | 2518199 | p.Ile29Val | missense_variant | 0.25 | isoniazid | |
kasA | 2518220 | c.106C>T | synonymous_variant | 0.25 | isoniazid | |
kasA | 2518459 | c.345T>C | synonymous_variant | 0.26 | isoniazid | |
kasA | 2518462 | c.348A>C | synonymous_variant | 0.3 | isoniazid | |
kasA | 2518468 | c.354A>C | synonymous_variant | 0.31 | isoniazid | |
kasA | 2518474 | c.360G>A | synonymous_variant | 0.32 | isoniazid | |
kasA | 2518480 | c.366T>C | synonymous_variant | 0.32 | isoniazid | |
kasA | 2518483 | c.369C>G | synonymous_variant | 0.32 | isoniazid | |
kasA | 2518504 | c.390T>C | synonymous_variant | 0.38 | isoniazid | |
kasA | 2518506 | p.Ala131Glu | missense_variant | 0.38 | isoniazid | |
kasA | 2518519 | c.405G>C | synonymous_variant | 0.36 | isoniazid | |
kasA | 2518528 | c.414C>G | synonymous_variant | 0.34 | isoniazid | |
kasA | 2518540 | c.426T>C | synonymous_variant | 0.42 | isoniazid | |
kasA | 2518561 | c.447T>C | synonymous_variant | 0.31 | isoniazid | |
kasA | 2518567 | c.453G>C | synonymous_variant | 0.29 | isoniazid | |
kasA | 2518684 | c.570C>G | synonymous_variant | 0.32 | isoniazid | |
kasA | 2518696 | c.582C>G | synonymous_variant | 0.33 | isoniazid | |
kasA | 2518702 | c.588C>T | synonymous_variant | 0.33 | isoniazid | |
kasA | 2518705 | c.591T>C | synonymous_variant | 0.35 | isoniazid | |
kasA | 2518711 | c.597A>G | synonymous_variant | 0.45 | isoniazid | |
kasA | 2518714 | c.600A>C | synonymous_variant | 0.45 | isoniazid | |
kasA | 2518732 | c.618C>G | synonymous_variant | 0.41 | isoniazid | |
kasA | 2518744 | c.630C>T | synonymous_variant | 0.32 | isoniazid | |
kasA | 2518747 | c.633C>G | synonymous_variant | 0.32 | isoniazid | |
kasA | 2518768 | c.654C>T | synonymous_variant | 0.3 | isoniazid | |
kasA | 2518777 | c.663C>T | synonymous_variant | 0.29 | isoniazid | |
kasA | 2518825 | c.711T>C | synonymous_variant | 0.42 | isoniazid | |
kasA | 2518864 | c.750G>C | synonymous_variant | 0.42 | isoniazid | |
kasA | 2518879 | c.765A>G | synonymous_variant | 0.36 | isoniazid | |
kasA | 2518885 | c.771T>C | synonymous_variant | 0.38 | isoniazid | |
kasA | 2518898 | c.784T>C | synonymous_variant | 0.35 | isoniazid | |
kasA | 2518906 | c.792A>G | synonymous_variant | 0.33 | isoniazid | |
kasA | 2518910 | p.Leu266Met | missense_variant | 0.29 | isoniazid | |
kasA | 2518919 | p.Gly269Ser | missense_variant | 0.7 | isoniazid | |
kasA | 2519107 | c.993T>C | synonymous_variant | 0.26 | isoniazid | |
kasA | 2519108 | p.Asp332Gln | missense_variant | 0.27 | isoniazid | |
kasA | 2519122 | c.1008G>C | synonymous_variant | 0.33 | isoniazid | |
kasA | 2519137 | c.1023T>G | synonymous_variant | 0.38 | isoniazid | |
kasA | 2519158 | c.1044C>T | synonymous_variant | 0.32 | isoniazid | |
ahpC | 2726528 | c.336C>G | synonymous_variant | 0.47 | isoniazid | |
ahpC | 2726540 | c.348C>G | synonymous_variant | 0.39 | isoniazid | |
ahpC | 2726543 | c.351A>G | synonymous_variant | 0.39 | isoniazid | |
ahpC | 2726546 | c.354C>G | synonymous_variant | 0.39 | isoniazid | |
ahpC | 2726551 | p.Gln120Leu | missense_variant | 0.37 | isoniazid | |
ahpC | 2726556 | p.Ala122Thr | missense_variant | 0.35 | isoniazid | Uncertain significance |
ahpC | 2726564 | c.372C>G | synonymous_variant | 0.35 | isoniazid | Not assoc w R - Interim |
ahpC | 2726591 | c.399C>G | synonymous_variant | 0.35 | isoniazid | |
ahpC | 2726593 | p.Val134Ala | missense_variant | 0.4 | isoniazid | |
ahpC | 2726600 | c.408T>C | synonymous_variant | 0.4 | isoniazid | |
ahpC | 2726601 | p.Ile137Leu | missense_variant | 0.4 | isoniazid | |
ahpC | 2726638 | p.Ala149Val | missense_variant | 0.31 | isoniazid | |
ahpC | 2726645 | c.453C>G | synonymous_variant | 0.31 | isoniazid | |
ahpC | 2726657 | c.465A>C | synonymous_variant | 0.34 | isoniazid | Not assoc w R - Interim |
ahpC | 2726669 | p.Asp159Glu | missense_variant | 0.28 | isoniazid | |
ahpC | 2726672 | c.480G>A | synonymous_variant | 0.26 | isoniazid | Not assoc w R - Interim |
ahpC | 2726675 | c.483A>G | synonymous_variant | 0.26 | isoniazid | |
ahpC | 2726681 | c.489A>C | synonymous_variant | 0.26 | isoniazid | Not assoc w R - Interim |
ahpC | 2726687 | c.495C>G | synonymous_variant | 0.28 | isoniazid | |
ahpC | 2726693 | c.501C>G | synonymous_variant | 0.28 | isoniazid | |
ahpC | 2726696 | c.504C>G | synonymous_variant | 0.26 | isoniazid | |
ahpC | 2726717 | c.525A>G | synonymous_variant | 0.2 | isoniazid | |
folC | 2747289 | p.Pro104Ala | missense_variant | 0.32 | para-aminosalicylic_acid | |
folC | 2747290 | c.309A>G | synonymous_variant | 0.33 | para-aminosalicylic_acid | |
folC | 2747293 | c.306G>A | synonymous_variant | 0.35 | para-aminosalicylic_acid | |
folC | 2747302 | c.297A>G | synonymous_variant | 0.43 | para-aminosalicylic_acid | |
folC | 2747314 | c.285A>C | synonymous_variant | 0.43 | para-aminosalicylic_acid | |
folC | 2747317 | c.282C>G | synonymous_variant | 0.43 | para-aminosalicylic_acid | |
folC | 2747343 | p.Val86Ile | missense_variant | 0.48 | para-aminosalicylic_acid | |
folC | 2747355 | p.Val82Ile | missense_variant | 0.44 | para-aminosalicylic_acid | |
folC | 2747359 | c.240C>G | synonymous_variant | 0.44 | para-aminosalicylic_acid | |
folC | 2747362 | c.237G>C | synonymous_variant | 0.44 | para-aminosalicylic_acid | |
folC | 2747394 | p.Ile69Val | missense_variant | 0.4 | para-aminosalicylic_acid | |
folC | 2747395 | c.204T>C | synonymous_variant | 0.4 | para-aminosalicylic_acid | |
Rv2477c | 2783098 | c.945C>G | synonymous_variant | 0.26 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783101 | c.942G>T | synonymous_variant | 0.26 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783107 | c.936G>A | synonymous_variant | 0.29 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783116 | c.927T>C | synonymous_variant | 0.29 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783140 | c.903C>G | synonymous_variant | 0.37 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783149 | c.894G>C | synonymous_variant | 0.41 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | ||||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783158 | c.885A>C | synonymous_variant | 0.43 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783182 | c.861C>G | synonymous_variant | 0.28 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783185 | c.858G>A | synonymous_variant | 0.27 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783194 | c.849A>G | synonymous_variant | 0.25 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783656 | c.387G>C | synonymous_variant | 0.25 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783665 | c.378A>G | synonymous_variant | 0.24 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783674 | c.369T>C | synonymous_variant | 0.25 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783700 | p.Thr115Ser | missense_variant | 0.35 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783718 | c.325T>C | synonymous_variant | 0.31 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783719 | c.324A>G | synonymous_variant | 0.3 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783751 | p.Ile98Val | missense_variant | 0.33 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783758 | p.Asp95Glu | missense_variant | 0.35 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783761 | c.282G>C | synonymous_variant | 0.39 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783766 | p.Met93Leu | missense_variant | 0.33 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783776 | c.267G>C | synonymous_variant | 0.29 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783779 | c.264T>C | synonymous_variant | 0.26 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783920 | c.123G>C | synonymous_variant | 0.36 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783929 | c.114C>G | synonymous_variant | 0.45 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783932 | c.111C>T | synonymous_variant | 0.43 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783938 | c.105T>C | synonymous_variant | 0.46 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783953 | c.90G>A | synonymous_variant | 0.44 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783962 | c.81T>C | synonymous_variant | 0.41 | kanamycin | Not assoc w R - Interim |
levofloxacin | ||||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783971 | c.72G>C | synonymous_variant | 0.35 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783980 | c.63C>G | synonymous_variant | 0.33 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783992 | c.51T>C | synonymous_variant | 0.31 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | ||||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2752c | 3064973 | p.Ala407Ser | missense_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3064974 | c.1218T>C | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3065040 | c.1152C>G | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
Rv2752c | 3065824 | p.Pro123Leu | missense_variant | 0.96 | levofloxacin | Not assoc w R |
moxifloxacin | Uncertain significance | |||||
isoniazid | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R | |||||
ethambutol | Not assoc w R | |||||
Rv2752c | 3066024 | c.168T>G | synonymous_variant | 0.3 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066040 | p.Gly51Thr | missense_variant | 0.29 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066042 | c.150T>C | synonymous_variant | 0.29 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066045 | c.147T>C | synonymous_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066050 | p.Leu48Met | missense_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066054 | c.138T>G | synonymous_variant | 0.31 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066066 | c.126T>C | synonymous_variant | 0.31 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066075 | c.117A>G | synonymous_variant | 0.29 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066330 | c.-139G>C | upstream_gene_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066335 | c.-144T>C | upstream_gene_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
Rv2752c | 3066339 | c.-148G>C | upstream_gene_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
thyX | 3067457 | c.489C>G | synonymous_variant | 0.27 | para-aminosalicylic_acid | |
thyX | 3067462 | c.484C>T | synonymous_variant | 0.29 | para-aminosalicylic_acid | |
thyX | 3067465 | p.Ile161Val | missense_variant | 0.32 | para-aminosalicylic_acid | |
thyX | 3067466 | c.480G>C | synonymous_variant | 0.32 | para-aminosalicylic_acid | |
thyX | 3067475 | c.471A>G | synonymous_variant | 0.35 | para-aminosalicylic_acid | |
thyX | 3067490 | c.456C>G | synonymous_variant | 0.4 | para-aminosalicylic_acid | |
thyX | 3067493 | c.453A>G | synonymous_variant | 0.37 | para-aminosalicylic_acid | |
thyX | 3067515 | p.Ser144Thr | missense_variant | 0.28 | para-aminosalicylic_acid | |
thyX | 3067530 | p.Ala139Ser | missense_variant | 0.33 | para-aminosalicylic_acid | |
thyX | 3067545 | p.Glu134Ala | missense_variant | 0.41 | para-aminosalicylic_acid | |
thyX | 3067549 | p.Thr133Ala | missense_variant | 0.43 | para-aminosalicylic_acid | |
thyX | 3067556 | p.His130Gln | missense_variant | 0.45 | para-aminosalicylic_acid | |
thyX | 3067559 | c.387C>G | synonymous_variant | 0.46 | para-aminosalicylic_acid | |
thyX | 3067565 | p.Asp127Glu | missense_variant | 0.45 | para-aminosalicylic_acid | |
thyX | 3067570 | p.Ala126Pro | missense_variant | 0.45 | para-aminosalicylic_acid | |
thyX | 3067577 | c.369G>A | synonymous_variant | 0.41 | para-aminosalicylic_acid | |
thyX | 3067601 | p.Arg115His | missense_variant | 0.44 | para-aminosalicylic_acid | |
thyX | 3067611 | p.Lys112Thr | missense_variant | 0.47 | para-aminosalicylic_acid | |
thyX | 3067619 | c.327A>C | synonymous_variant | 0.47 | para-aminosalicylic_acid | |
thyX | 3067631 | c.315C>G | synonymous_variant | 0.41 | para-aminosalicylic_acid | |
thyX | 3067634 | c.312C>G | synonymous_variant | 0.38 | para-aminosalicylic_acid | |
thyX | 3067637 | c.309G>A | synonymous_variant | 0.37 | para-aminosalicylic_acid | |
thyX | 3067652 | c.294T>C | synonymous_variant | 0.36 | para-aminosalicylic_acid | |
thyX | 3067661 | c.285C>G | synonymous_variant | 0.36 | para-aminosalicylic_acid | |
thyX | 3067685 | c.261A>C | synonymous_variant | 0.32 | para-aminosalicylic_acid | |
thyX | 3067691 | p.Ile85Leu | missense_variant | 0.26 | para-aminosalicylic_acid | |
thyX | 3067694 | c.252G>C | synonymous_variant | 0.26 | para-aminosalicylic_acid | |
thyX | 3067718 | c.228C>G | synonymous_variant | 0.28 | para-aminosalicylic_acid | |
thyX | 3067721 | c.225T>C | synonymous_variant | 0.32 | para-aminosalicylic_acid | |
thyX | 3067727 | c.219A>C | synonymous_variant | 0.33 | para-aminosalicylic_acid | |
thyX | 3067736 | c.210C>T | synonymous_variant | 0.33 | para-aminosalicylic_acid | |
thyX | 3067761 | p.Arg62Lys | missense_variant | 0.32 | para-aminosalicylic_acid | |
thyX | 3067765 | p.Leu61Ile | missense_variant | 0.32 | para-aminosalicylic_acid | |
thyX | 3067772 | c.174C>G | synonymous_variant | 0.36 | para-aminosalicylic_acid | |
thyX | 3067775 | c.171C>T | synonymous_variant | 0.35 | para-aminosalicylic_acid | |
thyX | 3067781 | c.165C>G | synonymous_variant | 0.39 | para-aminosalicylic_acid | |
thyX | 3067793 | c.153T>C | synonymous_variant | 0.41 | para-aminosalicylic_acid | |
thyX | 3067799 | c.147G>A | synonymous_variant | 0.41 | para-aminosalicylic_acid | |
thyX | 3067802 | c.144C>G | synonymous_variant | 0.4 | para-aminosalicylic_acid | |
thyX | 3067814 | c.132T>C | synonymous_variant | 0.43 | para-aminosalicylic_acid | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | rifampicin | Not assoc w R |
bedaquiline | Uncertain significance | |||||
lpqB | 3625161 | c.-251T>C | upstream_gene_variant | 0.27 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625162 | c.1452T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
bedaquiline | Not assoc w R - Interim | |||||
lpqB | 3625165 | c.-255G>C | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625186 | c.-276T>C | upstream_gene_variant | 0.37 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625189 | c.1425A>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625195 | c.-285A>G | upstream_gene_variant | 0.31 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625518 | c.-608T>C | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625525 | c.-615G>C | upstream_gene_variant | 0.28 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625528 | c.-618G>T | upstream_gene_variant | 0.28 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625537 | c.-627T>C | upstream_gene_variant | 0.33 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625543 | c.-633G>C | upstream_gene_variant | 0.36 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625569 | c.1045T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625572 | p.Thr348Ser | missense_variant | 0.33 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625579 | c.-669A>G | upstream_gene_variant | 0.36 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625594 | c.-684T>C | upstream_gene_variant | 0.37 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625602 | c.-692T>C | upstream_gene_variant | 0.37 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625612 | c.-702G>C | upstream_gene_variant | 0.3 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625624 | c.-714C>G | upstream_gene_variant | 0.33 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625636 | c.978C>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625656 | c.958T>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
bedaquiline | Not assoc w R - Interim | |||||
lpqB | 3625663 | c.-753G>C | upstream_gene_variant | 0.3 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625705 | c.909C>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625729 | c.885A>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625735 | c.-825C>T | upstream_gene_variant | 0.37 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625749 | c.-839C>T | upstream_gene_variant | 0.42 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625755 | p.Ala287Thr | missense_variant | 0.38 | rifampicin | Uncertain significance |
bedaquiline | ||||||
mtrB | 3625765 | c.849C>G | synonymous_variant | 0.44 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625774 | c.840G>A | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625797 | p.Val273Met | missense_variant | 0.4 | rifampicin | Uncertain significance |
bedaquiline | Uncertain significance | |||||
mtrB | 3625806 | c.808A>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625807 | c.807C>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625837 | c.777C>G | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625849 | c.-939T>C | upstream_gene_variant | 0.33 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625852 | c.762A>G | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625864 | c.-954T>G | upstream_gene_variant | 0.25 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626711 | c.-98T>C | upstream_gene_variant | 0.19 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626759 | c.591T>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626774 | c.-163_-161delAGGinsCGC | upstream_gene_variant | 0.31 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626783 | c.-170C>G | upstream_gene_variant | 0.27 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626786 | c.564A>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrA | 3626792 | c.558G>T | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626795 | c.-182C>T | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626798 | c.-185T>C | upstream_gene_variant | 0.28 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626804 | c.546A>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626840 | c.-227C>G | upstream_gene_variant | 0.41 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626846 | c.504G>A | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626858 | c.-245A>G | upstream_gene_variant | 0.33 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626861 | c.-248C>G | upstream_gene_variant | 0.31 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626866 | c.-253T>C | upstream_gene_variant | 0.28 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626869 | c.481C>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626876 | c.-263A>G | upstream_gene_variant | 0.27 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626885 | c.-272A>C | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626890 | c.-277T>C | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626903 | c.-290T>C | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626912 | c.-299T>G | upstream_gene_variant | 0.28 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626927 | c.-314G>C | upstream_gene_variant | 0.19 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626930 | c.-317A>G | upstream_gene_variant | 0.23 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626939 | c.411A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3626942 | c.-329A>C | upstream_gene_variant | 0.22 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626945 | c.-332C>T | upstream_gene_variant | 0.23 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626957 | c.-344G>C | upstream_gene_variant | 0.29 | rifampicin | |
bedaquiline | ||||||
mtrA | 3626969 | c.381C>T | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
bedaquiline | Not assoc w R - Interim | |||||
mtrB | 3626972 | c.-359A>G | upstream_gene_variant | 0.46 | rifampicin | |
bedaquiline | ||||||
mtrB | 3626987 | c.-374C>G | upstream_gene_variant | 0.46 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627011 | c.-398T>G | upstream_gene_variant | 0.36 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627065 | c.-452G>C | upstream_gene_variant | 0.29 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627068 | c.282T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrA | 3627071 | c.279G>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627074 | c.-461G>C | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627080 | c.270T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627083 | c.-470G>C | upstream_gene_variant | 0.27 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627098 | c.252A>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627104 | c.-491C>G | upstream_gene_variant | 0.31 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627119 | c.231T>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627122 | c.-509T>C | upstream_gene_variant | 0.33 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627146 | c.204C>T | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627167 | c.-554T>C | upstream_gene_variant | 0.34 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627181 | c.-568T>C | upstream_gene_variant | 0.39 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627182 | c.-569T>C | upstream_gene_variant | 0.38 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627188 | c.162A>G | synonymous_variant | 0.41 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627209 | c.-596G>A | upstream_gene_variant | 0.38 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627221 | c.129C>T | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrA | 3627227 | c.123T>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627233 | c.-620T>C | upstream_gene_variant | 0.3 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627236 | c.-623T>C | upstream_gene_variant | 0.33 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627275 | c.-662G>T | upstream_gene_variant | 0.25 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627296 | c.-683T>C | upstream_gene_variant | 0.29 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627299 | c.-688_-686delTTGinsCTA | upstream_gene_variant | 0.29 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627314 | c.-701C>T | upstream_gene_variant | 0.31 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627317 | c.-704T>C | upstream_gene_variant | 0.3 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627917 | c.-568G>C | upstream_gene_variant | 0.42 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627920 | c.-571A>G | upstream_gene_variant | 0.4 | rifampicin | |
bedaquiline | ||||||
fbiB | 3642719 | c.1185T>C | synonymous_variant | 0.3 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
rpoA | 3877587 | c.921A>G | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoA | 3877613 | p.Ile299Val | missense_variant | 0.29 | rifampicin | |
rpoA | 3877656 | c.852T>G | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoA | 3877668 | c.840A>G | synonymous_variant | 0.34 | rifampicin | |
rpoA | 3877679 | p.Ala277Ser | missense_variant | 0.33 | rifampicin | |
rpoA | 3877686 | c.822A>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoA | 3877692 | c.816G>C | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoA | 3877704 | c.804G>C | synonymous_variant | 0.41 | rifampicin | |
rpoA | 3877737 | c.771G>C | synonymous_variant | 0.32 | rifampicin | |
rpoA | 3877743 | c.765T>C | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoA | 3877764 | c.744C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoA | 3877770 | c.738A>G | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoA | 3877776 | c.732T>C | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoA | 3877782 | c.726T>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoA | 3877791 | c.717C>G | synonymous_variant | 0.43 | rifampicin | |
rpoA | 3877818 | c.690A>G | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoA | 3877839 | c.669G>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoA | 3877848 | c.660C>T | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoA | 3877857 | c.651G>A | synonymous_variant | 0.4 | rifampicin | |
rpoA | 3877866 | c.642G>C | synonymous_variant | 0.42 | rifampicin | |
rpoA | 3877875 | c.633T>G | synonymous_variant | 0.34 | rifampicin | |
rpoA | 3877878 | c.630G>C | synonymous_variant | 0.35 | rifampicin | |
rpoA | 3877890 | c.618C>T | synonymous_variant | 0.36 | rifampicin | |
rpoA | 3877896 | c.612G>C | synonymous_variant | 0.33 | rifampicin | |
rpoA | 3877900 | p.Ser203Asn | missense_variant | 0.31 | rifampicin | |
rpoA | 3877905 | c.603A>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoA | 3877909 | p.Asn200Ser | missense_variant | 0.32 | rifampicin | |
rpoA | 3877920 | c.588G>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoA | 3877923 | c.585C>T | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoA | 3877926 | c.582G>C | synonymous_variant | 0.34 | rifampicin | |
rpoA | 3877962 | c.546G>T | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoA | 3877989 | c.519A>G | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoA | 3878001 | c.507A>G | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoA | 3878022 | c.486T>C | synonymous_variant | 0.28 | rifampicin | |
rpoA | 3878028 | c.480G>C | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3878031 | c.477T>C | synonymous_variant | 0.27 | rifampicin | |
rpoA | 3878040 | c.468T>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoA | 3878055 | c.453A>G | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3878058 | c.450G>T | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3878061 | c.447G>C | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3878067 | c.441C>G | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878070 | c.438T>C | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878076 | c.432C>T | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3878193 | c.315T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3878199 | c.309T>C | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3878217 | c.291A>G | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoA | 3878226 | c.282C>G | synonymous_variant | 0.41 | rifampicin | |
rpoA | 3878232 | c.276G>C | synonymous_variant | 0.43 | rifampicin | |
rpoA | 3878247 | c.261G>C | synonymous_variant | 0.5 | rifampicin | |
rpoA | 3878271 | c.237T>C | synonymous_variant | 0.42 | rifampicin | Not assoc w R - Interim |
rpoA | 3878284 | p.Glu75Ala | missense_variant | 0.4 | rifampicin | |
rpoA | 3878292 | c.216T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoA | 3878298 | c.210A>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoA | 3878304 | c.204G>C | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3878313 | c.195G>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoA | 3878322 | c.186A>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoA | 3878331 | c.177A>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoA | 3878334 | c.174T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoA | 3878337 | c.171T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoA | 3878346 | c.162T>C | synonymous_variant | 0.29 | rifampicin | |
rpoA | 3878364 | c.144A>T | synonymous_variant | 0.28 | rifampicin | |
rpoA | 3878367 | c.141C>G | synonymous_variant | 0.3 | rifampicin | |
rpoA | 3878376 | c.132G>C | synonymous_variant | 0.37 | rifampicin | |
rpoA | 3878385 | c.123C>G | synonymous_variant | 0.38 | rifampicin | |
rpoA | 3878388 | c.120C>G | synonymous_variant | 0.39 | rifampicin | |
rpoA | 3878391 | c.117T>C | synonymous_variant | 0.42 | rifampicin | |
rpoA | 3878415 | c.93C>T | synonymous_variant | 0.44 | rifampicin | |
rpoA | 3878424 | c.84G>C | synonymous_variant | 0.48 | rifampicin | |
rpoA | 3878436 | c.72A>G | synonymous_variant | 0.47 | rifampicin | |
rpoA | 3878442 | c.66G>C | synonymous_variant | 0.43 | rifampicin | |
rpoA | 3878454 | c.54A>C | synonymous_variant | 0.38 | rifampicin | |
rpoA | 3878761 | c.-254G>C | upstream_gene_variant | 0.37 | rifampicin | |
rpoA | 3878764 | c.-257A>G | upstream_gene_variant | 0.37 | rifampicin | |
rpoA | 3878785 | c.-278T>G | upstream_gene_variant | 0.38 | rifampicin | |
rpoA | 3878788 | c.-281G>C | upstream_gene_variant | 0.35 | rifampicin | Uncertain significance |
rpoA | 3878806 | c.-299C>G | upstream_gene_variant | 0.38 | rifampicin | |
rpoA | 3878809 | c.-302T>C | upstream_gene_variant | 0.39 | rifampicin | |
rpoA | 3878853 | c.-346G>A | upstream_gene_variant | 0.44 | rifampicin | |
rpoA | 3878878 | c.-371T>C | upstream_gene_variant | 0.41 | rifampicin | Uncertain significance |
rpoA | 3878909 | c.-402A>G | upstream_gene_variant | 0.33 | rifampicin | |
rpoA | 3878914 | c.-407T>C | upstream_gene_variant | 0.27 | rifampicin | Uncertain significance |
rpoA | 3878938 | c.-431T>C | upstream_gene_variant | 0.32 | rifampicin | |
rpoA | 3878947 | c.-440G>C | upstream_gene_variant | 0.36 | rifampicin | Uncertain significance |
rpoA | 3878986 | c.-479G>C | upstream_gene_variant | 0.3 | rifampicin | |
rpoA | 3878998 | c.-491C>G | upstream_gene_variant | 0.25 | rifampicin | Uncertain significance |
rpoA | 3879005 | c.-499_-498delAAinsCG | upstream_gene_variant | 0.25 | rifampicin | |
rpoA | 3879013 | c.-506A>G | upstream_gene_variant | 0.26 | rifampicin | |
rpoA | 3879079 | c.-572A>G | upstream_gene_variant | 0.27 | rifampicin | |
rpoA | 3879088 | c.-581A>C | upstream_gene_variant | 0.3 | rifampicin | |
rpoA | 3879094 | c.-587T>C | upstream_gene_variant | 0.31 | rifampicin | |
rpoA | 3879127 | c.-620T>C | upstream_gene_variant | 0.35 | rifampicin | |
rpoA | 3879154 | c.-647T>C | upstream_gene_variant | 0.48 | rifampicin | |
rpoA | 3879160 | c.-653A>G | upstream_gene_variant | 0.54 | rifampicin | |
rpoA | 3879178 | c.-671T>C | upstream_gene_variant | 0.56 | rifampicin | |
rpoA | 3879190 | c.-683C>G | upstream_gene_variant | 0.53 | rifampicin | |
rpoA | 3879222 | c.-715T>C | upstream_gene_variant | 0.47 | rifampicin | |
rpoA | 3879226 | c.-719G>C | upstream_gene_variant | 0.3 | rifampicin | |
clpC1 | 4038287 | c.2418C>T | synonymous_variant | 0.82 | pyrazinamide | Not assoc w R |
clpC1 | 4038302 | c.2403C>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038308 | c.2397G>T | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4038314 | c.2391T>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038317 | c.2388G>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038320 | c.2385G>T | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4038356 | c.2349T>C | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4038359 | c.2346A>G | synonymous_variant | 0.3 | pyrazinamide | |
clpC1 | 4038368 | c.2337T>C | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4038388 | c.2317T>C | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4038392 | c.2313C>T | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4038398 | c.2307G>T | synonymous_variant | 0.29 | pyrazinamide | |
clpC1 | 4038596 | c.2109A>G | synonymous_variant | 0.3 | pyrazinamide | |
clpC1 | 4038640 | p.Asp689Asn | missense_variant | 0.21 | pyrazinamide | |
clpC1 | 4038653 | c.2052C>T | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038671 | c.2034T>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038695 | c.2010C>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038701 | c.2004G>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038704 | c.2001T>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4038707 | c.1998C>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038710 | c.1995G>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4038713 | c.1992T>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4038749 | c.1956C>G | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4038755 | c.1950G>T | synonymous_variant | 0.33 | pyrazinamide | |
clpC1 | 4038770 | c.1935C>T | synonymous_variant | 0.37 | pyrazinamide | |
clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.37 | pyrazinamide | |
clpC1 | 4038782 | c.1923G>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4038845 | c.1860G>C | synonymous_variant | 0.42 | pyrazinamide | |
clpC1 | 4038860 | c.1845G>C | synonymous_variant | 0.36 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.28 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038974 | c.1731T>C | synonymous_variant | 0.42 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038989 | c.1716T>C | synonymous_variant | 0.42 | pyrazinamide | |
clpC1 | 4038997 | c.1708T>C | synonymous_variant | 0.34 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039004 | c.1701C>G | synonymous_variant | 0.35 | pyrazinamide | |
clpC1 | 4039022 | c.1683A>G | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039097 | c.1608G>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039103 | c.1602T>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039106 | c.1599G>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039112 | c.1593C>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039142 | c.1563A>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039145 | c.1560G>C | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039169 | p.Glu512Asp | missense_variant | 0.26 | pyrazinamide | |
clpC1 | 4039172 | c.1533A>G | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4039178 | c.1527G>C | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4039183 | c.1522T>C | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039186 | c.1519C>T | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039226 | c.1479T>C | synonymous_variant | 0.23 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039349 | c.1356C>T | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4039352 | c.1353C>G | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4039364 | c.1341C>G | synonymous_variant | 0.29 | pyrazinamide | |
clpC1 | 4039391 | c.1314T>G | synonymous_variant | 0.35 | pyrazinamide | |
clpC1 | 4039409 | c.1296T>C | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4039412 | c.1293T>G | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4039415 | p.Glu430Asp | missense_variant | 0.32 | pyrazinamide | Uncertain significance |
clpC1 | 4039430 | c.1275T>C | synonymous_variant | 0.37 | pyrazinamide | |
clpC1 | 4039442 | c.1263A>G | synonymous_variant | 0.46 | pyrazinamide | |
clpC1 | 4039517 | c.1188C>G | synonymous_variant | 0.28 | pyrazinamide | |
clpC1 | 4039661 | c.1044T>G | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039664 | c.1041G>C | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4039694 | c.1011G>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039724 | c.981A>G | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4039751 | c.954A>G | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4039757 | c.948A>G | synonymous_variant | 0.41 | pyrazinamide | |
clpC1 | 4039760 | c.945T>C | synonymous_variant | 0.33 | pyrazinamide | |
clpC1 | 4039766 | c.939T>C | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4039769 | c.936C>G | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039775 | c.930G>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039778 | c.927A>G | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039781 | c.924G>C | synonymous_variant | 0.31 | pyrazinamide | |
clpC1 | 4039790 | c.915C>G | synonymous_variant | 0.4 | pyrazinamide | |
clpC1 | 4039898 | c.807C>G | synonymous_variant | 0.44 | pyrazinamide | |
clpC1 | 4039928 | c.775_777delAGCinsTCG | synonymous_variant | 0.34 | pyrazinamide | |
clpC1 | 4039931 | c.774T>C | synonymous_variant | 0.36 | pyrazinamide | |
clpC1 | 4039937 | c.768G>C | synonymous_variant | 0.38 | pyrazinamide | |
clpC1 | 4039946 | c.759A>C | synonymous_variant | 0.4 | pyrazinamide | |
clpC1 | 4039952 | c.753T>C | synonymous_variant | 0.41 | pyrazinamide | |
clpC1 | 4039979 | c.726C>G | synonymous_variant | 0.44 | pyrazinamide | |
clpC1 | 4039988 | c.717C>G | synonymous_variant | 0.4 | pyrazinamide | |
clpC1 | 4039991 | c.714G>C | synonymous_variant | 0.39 | pyrazinamide | |
clpC1 | 4040021 | c.684A>C | synonymous_variant | 0.37 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040024 | c.681A>G | synonymous_variant | 0.39 | pyrazinamide | |
clpC1 | 4040033 | c.672G>C | synonymous_variant | 0.42 | pyrazinamide | |
clpC1 | 4040036 | c.669C>G | synonymous_variant | 0.45 | pyrazinamide | |
clpC1 | 4040090 | c.613_615delTCTinsAGC | synonymous_variant | 0.36 | pyrazinamide | |
clpC1 | 4040093 | c.612C>G | synonymous_variant | 0.38 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040105 | c.600C>G | synonymous_variant | 0.43 | pyrazinamide | |
clpC1 | 4040147 | c.558A>G | synonymous_variant | 0.4 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040162 | c.543G>C | synonymous_variant | 0.35 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040165 | c.540G>C | synonymous_variant | 0.34 | pyrazinamide | |
clpC1 | 4040171 | c.534C>G | synonymous_variant | 0.37 | pyrazinamide | |
clpC1 | 4040471 | c.234T>C | synonymous_variant | 0.23 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040477 | c.228G>C | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4040480 | c.225T>G | synonymous_variant | 0.24 | pyrazinamide | |
panD | 4045000 | c.-719A>C | upstream_gene_variant | 0.32 | pyrazinamide | |
panD | 4045001 | c.-720G>C | upstream_gene_variant | 0.31 | pyrazinamide | |
panD | 4045019 | c.-738G>C | upstream_gene_variant | 0.33 | pyrazinamide | |
panD | 4045022 | c.-741C>G | upstream_gene_variant | 0.28 | pyrazinamide | |
panD | 4045028 | c.-747C>G | upstream_gene_variant | 0.3 | pyrazinamide | |
panD | 4045034 | c.-753A>C | upstream_gene_variant | 0.33 | pyrazinamide | |
panD | 4045055 | c.-774T>G | upstream_gene_variant | 0.28 | pyrazinamide | |
glpK | 4138670 | c.1086G>C | synonymous_variant | 0.33 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138679 | p.Met359Val | missense_variant | 0.4 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138695 | p.Pro354Asp | missense_variant | 0.64 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139126 | c.630G>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139132 | c.624A>C | synonymous_variant | 0.27 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
isoniazid | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
glpK | 4139135 | p.Asp207Asn | missense_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139143 | c.613T>C | synonymous_variant | 0.29 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139165 | c.591A>G | synonymous_variant | 0.37 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139168 | c.588T>C | synonymous_variant | 0.36 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139177 | c.579T>C | synonymous_variant | 0.36 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139183 | c.573T>C | synonymous_variant | 0.38 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139186 | c.570G>C | synonymous_variant | 0.32 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
glpK | 4139195 | c.561G>T | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | Not assoc w R - Interim | |||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
glpK | 4139198 | c.558C>G | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
glpK | 4139207 | c.549T>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139597 | c.159C>G | synonymous_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139601 | p.Arg52Gln | missense_variant | 0.31 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4139615 | c.141G>A | synonymous_variant | 0.37 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
isoniazid | Not assoc w R - Interim | |||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | ||||||
glpK | 4139651 | p.His35Glu | missense_variant | 0.43 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
embC | 4240677 | p.Gly272Ala | missense_variant | 0.42 | ethambutol | |
embC | 4240685 | p.Thr275Ala | missense_variant | 0.43 | ethambutol | |
embC | 4240693 | c.831T>G | synonymous_variant | 0.48 | ethambutol | |
embC | 4240699 | c.837C>G | synonymous_variant | 0.46 | ethambutol | Not assoc w R - Interim |
embC | 4240726 | c.864G>C | synonymous_variant | 0.48 | ethambutol | Not assoc w R - Interim |
embC | 4240780 | c.918T>C | synonymous_variant | 0.41 | ethambutol | |
embC | 4240783 | c.921G>C | synonymous_variant | 0.37 | ethambutol | |
embC | 4240789 | c.927T>C | synonymous_variant | 0.34 | ethambutol | |
embC | 4240819 | c.957A>G | synonymous_variant | 0.29 | ethambutol | |
embC | 4240828 | c.966G>A | synonymous_variant | 0.33 | ethambutol | |
embC | 4240831 | c.969T>G | synonymous_variant | 0.33 | ethambutol | |
embC | 4241095 | c.1233C>T | synonymous_variant | 0.3 | ethambutol | |
embC | 4241107 | c.1245G>C | synonymous_variant | 0.31 | ethambutol | |
embC | 4241140 | c.1278A>G | synonymous_variant | 0.32 | ethambutol | Not assoc w R - Interim |
embC | 4241146 | c.1284C>G | synonymous_variant | 0.35 | ethambutol | |
embC | 4241158 | c.1296T>C | synonymous_variant | 0.33 | ethambutol | |
embC | 4241161 | c.1299C>G | synonymous_variant | 0.35 | ethambutol | Not assoc w R - Interim |
embC | 4241162 | c.1300T>C | synonymous_variant | 0.35 | ethambutol | |
embC | 4241170 | c.1308G>C | synonymous_variant | 0.35 | ethambutol | |
embC | 4241173 | c.1311C>T | synonymous_variant | 0.35 | ethambutol | |
embC | 4241567 | p.Ile569Val | missense_variant | 0.27 | ethambutol | |
embC | 4241572 | c.1710C>G | synonymous_variant | 0.28 | ethambutol | |
embC | 4241578 | c.1716G>C | synonymous_variant | 0.28 | ethambutol | |
embC | 4241584 | c.1722T>C | synonymous_variant | 0.27 | ethambutol | |
embC | 4241587 | c.1725C>G | synonymous_variant | 0.27 | ethambutol | |
embC | 4241591 | p.Leu577Val | missense_variant | 0.27 | ethambutol | |
embC | 4242643 | c.2781C>T | synonymous_variant | 0.96 | ethambutol | Not assoc w R |
embA | 4244543 | c.1311C>G | synonymous_variant | 0.27 | ethambutol | |
embA | 4244547 | p.Ile439Val | missense_variant | 0.27 | ethambutol | |
embA | 4244557 | p.Arg442Thr | missense_variant | 0.3 | ethambutol | |
embA | 4244582 | c.1350T>C | synonymous_variant | 0.33 | ethambutol | |
embA | 4244585 | c.1353A>G | synonymous_variant | 0.33 | ethambutol | Not assoc w R - Interim |
embA | 4244611 | p.Ala460Gly | missense_variant | 0.37 | ethambutol | |
embA | 4245060 | c.1828T>C | synonymous_variant | 0.22 | ethambutol | |
embA | 4245083 | c.1851A>C | synonymous_variant | 0.32 | ethambutol | |
embA | 4245089 | c.1857G>C | synonymous_variant | 0.33 | ethambutol | |
embA | 4245101 | c.1869G>C | synonymous_variant | 0.33 | ethambutol | |
embA | 4245137 | c.1905T>C | synonymous_variant | 0.38 | ethambutol | |
embA | 4245146 | c.1914G>A | synonymous_variant | 0.31 | ethambutol | |
embA | 4245149 | c.1917C>G | synonymous_variant | 0.31 | ethambutol | |
embA | 4245153 | p.Ile641Val | missense_variant | 0.31 | ethambutol | |
embA | 4245182 | c.1950T>C | synonymous_variant | 0.37 | ethambutol | |
embA | 4245189 | c.1957C>T | synonymous_variant | 0.38 | ethambutol | |
embA | 4245198 | p.Leu656Ile | missense_variant | 0.4 | ethambutol | |
embA | 4245207 | c.1975T>C | synonymous_variant | 0.41 | ethambutol | |
embA | 4245215 | c.1983A>C | synonymous_variant | 0.4 | ethambutol | |
embA | 4245222 | p.Tyr664Gln | missense_variant | 0.41 | ethambutol | |
embA | 4245248 | c.2016G>C | synonymous_variant | 0.41 | ethambutol | |
embA | 4245257 | c.2025A>G | synonymous_variant | 0.39 | ethambutol | |
embA | 4245263 | c.2031A>G | synonymous_variant | 0.42 | ethambutol | Not assoc w R - Interim |
embA | 4245785 | c.2553G>C | synonymous_variant | 0.17 | ethambutol | Not assoc w R - Interim |
embB | 4245833 | c.-681G>C | upstream_gene_variant | 0.18 | ethambutol | |
embB | 4245842 | c.-672G>C | upstream_gene_variant | 0.24 | ethambutol | |
embB | 4245845 | c.-669T>C | upstream_gene_variant | 0.23 | ethambutol | |
embB | 4245851 | c.-663G>C | upstream_gene_variant | 0.22 | ethambutol | |
embB | 4245860 | c.-654C>G | upstream_gene_variant | 0.23 | ethambutol | |
embA | 4246235 | c.3003G>A | synonymous_variant | 0.21 | ethambutol | Not assoc w R - Interim |
embA | 4246242 | p.Gln1004Gly | missense_variant | 0.24 | ethambutol | |
embB | 4246250 | c.-264G>C | upstream_gene_variant | 0.26 | ethambutol | |
embB | 4246256 | c.-258G>T | upstream_gene_variant | 0.26 | ethambutol | |
embB | 4246259 | c.-255G>C | upstream_gene_variant | 0.26 | ethambutol | |
embA | 4246264 | p.His1011Arg | missense_variant | 0.28 | ethambutol | |
embB | 4246292 | c.-222A>G | upstream_gene_variant | 0.34 | ethambutol | |
embB | 4247464 | c.951C>G | synonymous_variant | 0.24 | ethambutol | |
embB | 4247470 | c.957T>C | synonymous_variant | 0.25 | ethambutol | |
embB | 4247491 | c.978G>C | synonymous_variant | 0.42 | ethambutol | |
embB | 4247497 | c.984T>C | synonymous_variant | 0.42 | ethambutol | |
embB | 4247512 | c.999T>C | synonymous_variant | 0.44 | ethambutol | |
embB | 4247539 | c.1026T>C | synonymous_variant | 0.4 | ethambutol | |
embB | 4247554 | c.1041T>C | synonymous_variant | 0.33 | ethambutol | |
embB | 4248070 | c.1557T>C | synonymous_variant | 0.31 | ethambutol | |
embB | 4248085 | c.1572T>C | synonymous_variant | 0.32 | ethambutol | |
embB | 4248142 | c.1629T>C | synonymous_variant | 0.28 | ethambutol | |
embB | 4248143 | c.1630T>C | synonymous_variant | 0.28 | ethambutol | |
embB | 4248157 | c.1644A>G | synonymous_variant | 0.29 | ethambutol | Not assoc w R - Interim |
embB | 4248172 | c.1659G>C | synonymous_variant | 0.29 | ethambutol | |
embB | 4248199 | c.1686A>G | synonymous_variant | 0.24 | ethambutol | |
embB | 4248200 | p.Ile563Val | missense_variant | 0.24 | ethambutol | |
embB | 4248205 | c.1692C>G | synonymous_variant | 0.24 | ethambutol | |
embB | 4248206 | p.Ser565Gly | missense_variant | 0.24 | ethambutol | Uncertain significance |
embB | 4248220 | c.1707A>C | synonymous_variant | 0.34 | ethambutol | |
embB | 4248304 | c.1791G>C | synonymous_variant | 0.26 | ethambutol | |
embB | 4248316 | c.1803C>G | synonymous_variant | 0.27 | ethambutol | |
embB | 4248319 | c.1806A>G | synonymous_variant | 0.31 | ethambutol | |
embB | 4248373 | c.1860C>G | synonymous_variant | 0.29 | ethambutol | |
embB | 4248382 | c.1869C>G | synonymous_variant | 0.25 | ethambutol | |
embB | 4248386 | c.1873C>A | synonymous_variant | 0.23 | ethambutol | |
embB | 4249417 | c.2904A>G | synonymous_variant | 0.43 | ethambutol | |
embB | 4249423 | p.Asp970Glu | missense_variant | 0.42 | ethambutol | Uncertain significance |
embB | 4249424 | p.Leu971Met | missense_variant | 0.42 | ethambutol | |
embB | 4249429 | c.2916C>T | synonymous_variant | 0.39 | ethambutol | |
embB | 4249432 | c.2919A>G | synonymous_variant | 0.41 | ethambutol | |
embB | 4249441 | c.2928A>G | synonymous_variant | 0.38 | ethambutol | Not assoc w R - Interim |
embB | 4249444 | c.2931T>C | synonymous_variant | 0.35 | ethambutol | |
embB | 4249469 | p.Leu986Met | missense_variant | 0.34 | ethambutol | |
embB | 4249486 | c.2973T>G | synonymous_variant | 0.33 | ethambutol | |
embB | 4249498 | c.2985G>C | synonymous_variant | 0.32 | ethambutol | |
aftB | 4268138 | c.699A>C | synonymous_variant | 0.23 | ethambutol | Not assoc w R - Interim |
aftB | 4268144 | c.693T>C | synonymous_variant | 0.22 | ethambutol | |
aftB | 4268164 | p.Gln225Glu | missense_variant | 0.23 | ethambutol | |
aftB | 4268169 | p.Ala223Gly | missense_variant | 0.24 | ethambutol | |
aftB | 4268171 | c.666G>C | synonymous_variant | 0.24 | ethambutol | |
aftB | 4269201 | c.-365A>G | upstream_gene_variant | 0.28 | ethambutol | |
aftB | 4269206 | c.-370C>T | upstream_gene_variant | 0.28 | ethambutol | |
ubiA | 4269220 | p.Ala205Lys | missense_variant | 0.28 | ethambutol | |
ubiA | 4269222 | c.612T>C | synonymous_variant | 0.28 | ethambutol | Not assoc w R - Interim |
aftB | 4269242 | c.-406C>T | upstream_gene_variant | 0.29 | ethambutol | |
ubiA | 4269243 | p.His197Gln | missense_variant | 0.29 | ethambutol | |
aftB | 4269249 | c.-413G>A | upstream_gene_variant | 0.29 | ethambutol | |
aftB | 4269258 | c.-422C>T | upstream_gene_variant | 0.29 | ethambutol | |
ubiA | 4269271 | p.Val188Ala | missense_variant | 0.77 | ethambutol | Uncertain significance |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
gid | 4408156 | p.Leu16Arg | missense_variant | 1.0 | streptomycin | Not assoc w R |