TB-Profiler result

Run: SRR1184298
Summary

Run ID: SRR1184298

Sample name:

Date: 2024-04-14T03:12:02.877408

Number of reads: 1109668

Percentage reads mapped: 65.34

Median coverage: 25.0

Strain: lineage4.3.3

Spoligotype:

Drug-resistance: Pre-XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.98
lineage4 Euro-American None 0.99
lineage4.3.3 Euro-American (LAM) RD115 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Asp435Gly Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.Leu452Pro Assoc w R
isoniazid inhA c.-770T>A Assoc w R - Interim Alias fabG1_c.-8T>A. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Val Assoc w R
pyrazinamide pncA c.456dupC Assoc w R
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
gid c.160_290del Assoc w R
fluoroquinolones
moxifloxacin gyrA p.Ala90Val Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ofloxacin
levofloxacin gyrA p.Ala90Val Assoc w R
ciprofloxacin
aminoglycosides
amikacin rrs n.1401A>G Assoc w R
capreomycin rrs n.1401A>G Assoc w R
kanamycin rrs n.1401A>G Assoc w R
cycloserine
ethionamide inhA c.-770T>A Assoc w R - Interim Alias fabG1_c.-8T>A
ethA c.-11A>G Uncertain significance Mutation from literature
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1024_1026delGAAinsCG Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7570 p.Ala90Val missense_variant 0.73 moxifloxacin Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
levofloxacin Assoc w R
rpoB 761110 p.Asp435Gly missense_variant 0.69 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761161 p.Leu452Pro missense_variant 0.65 rifampicin Assoc w R
fbiC 1303954 c.1024_1026delGAAinsCG frameshift_variant&missense_variant 0.26 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance Mutation from literature
rrs 1473246 n.1401A>G non_coding_transcript_exon_variant 0.59 kanamycin Assoc w R
capreomycin Assoc w R
amikacin Assoc w R
inhA 1673432 c.-770T>A upstream_gene_variant 1.0 ethionamide Assoc w R - Interim Alias fabG1_c.-8T>A
isoniazid Assoc w R - Interim Alias fabG1_c.-8T>A. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
pncA 2288785 c.456dupC frameshift_variant 0.92 pyrazinamide Assoc w R
embB 4247429 p.Met306Val missense_variant 0.89 ethambutol Assoc w R
ethA 4327484 c.-11A>G upstream_gene_variant 1.0 ethionamide Uncertain significance Mutation from literature
gid 4407912 c.160_290del frameshift_variant 1.0 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 510 c.510T>C synonymous_variant 0.17 isoniazid
dnaA 519 c.519C>G synonymous_variant 0.18 isoniazid Not assoc w R
dnaA 558 c.558G>C synonymous_variant 0.29 isoniazid
dnaA 561 c.561C>T synonymous_variant 0.28 isoniazid
dnaA 567 c.567C>G synonymous_variant 0.31 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.28 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 585 c.585A>G synonymous_variant 0.26 isoniazid
dnaA 588 c.588A>C synonymous_variant 0.27 isoniazid
dnaA 591 c.591C>G synonymous_variant 0.28 isoniazid
dnaA 600 c.600T>G synonymous_variant 0.3 isoniazid
dnaA 627 c.627G>A synonymous_variant 0.26 isoniazid
dnaA 693 c.693A>G synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 705 c.705A>G synonymous_variant 0.23 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.22 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.2 isoniazid
dnaA 756 c.756T>C synonymous_variant 0.2 isoniazid
dnaA 768 c.768C>G synonymous_variant 0.18 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.19 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.15 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.37 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.36 isoniazid
dnaA 1236 c.1236C>T synonymous_variant 0.36 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.38 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.41 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.48 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.5 isoniazid
dnaA 1284 c.1284C>G synonymous_variant 0.51 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.51 isoniazid
dnaA 1293 c.1293T>C synonymous_variant 0.47 isoniazid
dnaA 1299 c.1299G>C synonymous_variant 0.38 isoniazid Not assoc w R - Interim
dnaA 1302 c.1302C>G synonymous_variant 0.37 isoniazid
dnaA 1311 c.1311C>G synonymous_variant 0.32 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.31 isoniazid
dnaA 1317 c.1317A>G synonymous_variant 0.29 isoniazid
dnaA 1320 c.1320G>C synonymous_variant 0.29 isoniazid
dnaA 1332 c.1332A>C synonymous_variant 0.32 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.33 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.25 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.3 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.3 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.3 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.32 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.33 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.32 isoniazid
gyrB 6115 c.876A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6123 p.Ala295Gly missense_variant 0.19 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6130 c.891T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6139 c.900G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6196 c.957C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6346 c.1107C>T synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6362 c.-940T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6518 p.Val427Met missense_variant 0.95 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 6649 c.-653T>C upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.47 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.44 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.41 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 6841 c.1602T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6868 c.-434G>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6877 c.-425G>T upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642_1644delTTGinsCC frameshift_variant&missense_variant 0.26 levofloxacin Uncertain significance
moxifloxacin
gyrA 6889 c.-413G>T upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6901 c.-401G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7066 c.-236G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.32 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7216 c.1977G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7412 c.111C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7532 c.231T>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8040 p.Gly247Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8111 c.810G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.4 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.34 levofloxacin
moxifloxacin
gyrA 8270 c.969G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.29 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8597 c.1296C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318_1320delTTGinsCA frameshift_variant&missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 8624 c.1323G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8730 p.Gly477Arg missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin
gyrA 9161 c.1860C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.31 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9674 c.2373T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
fgd1 490848 c.66A>G synonymous_variant 0.38 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.38 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>A synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fgd1 490890 c.108C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491601 c.819T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491610 c.828A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491616 c.834A>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491620 p.Ile280Val missense_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>A synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491658 c.876A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
mshA 575809 c.462C>T synonymous_variant 0.27 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.26 ethionamide
isoniazid
ccsA 620340 c.450C>G synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620346 c.456C>G synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620373 c.483C>T synonymous_variant 0.23 capreomycin
amikacin
kanamycin
ccsA 620376 c.486G>C synonymous_variant 0.23 capreomycin
amikacin
kanamycin
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.25 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.27 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.26 ethionamide
hadA 731774 c.-156T>C upstream_gene_variant 0.46 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.46 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.46 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.32 isoniazid
hadA 731816 c.-114G>A upstream_gene_variant 0.24 isoniazid
hadA 731840 c.-90G>C upstream_gene_variant 0.18 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.18 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.26 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.26 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.27 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.29 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.28 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.27 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.27 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.32 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.32 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.39 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.38 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.38 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.35 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.41 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
nusG 734826 c.573A>C synonymous_variant 0.32 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
nusG 734841 c.588G>C synonymous_variant 0.29 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.26 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.26 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.26 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.26 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.23 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.24 rifampicin
rpoB 760060 p.Tyr85Leu missense_variant 0.25 rifampicin
rpoB 760067 c.261G>C synonymous_variant 0.27 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.26 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.4 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.52 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.52 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.4 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.4 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.4 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.36 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.36 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.36 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.38 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.43 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.42 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760472 c.666C>T synonymous_variant 0.35 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.32 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.27 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.22 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.23 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.23 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.28 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.25 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.27 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.4 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.46 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.29 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.33 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.36 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.38 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.38 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.42 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.33 rifampicin
rpoB 761477 c.1671C>G synonymous_variant 0.32 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.38 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.37 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.35 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.31 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.41 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.37 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.33 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.21 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.22 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.26 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.44 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.34 rifampicin Uncertain significance
rpoB 762149 c.2343G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.34 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.26 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.24 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.26 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.34 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.38 rifampicin
rpoB 762827 c.3021G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.33 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.44 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763067 c.-303C>G upstream_gene_variant 0.35 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763123 p.Ile1106Thr missense_variant 0.68 rifampicin Uncertain significance
rpoB 763136 c.3330C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.28 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.22 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.2 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.27 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.43 rifampicin
rpoC 763492 c.123G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763606 c.237C>T synonymous_variant 0.39 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.36 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.39 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.41 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.39 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.39 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.36 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.38 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.34 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.39 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.46 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.48 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.4 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.42 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.42 rifampicin
rpoC 763915 c.546C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764059 c.690G>T synonymous_variant 0.29 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.38 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.33 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.33 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.38 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.23 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.21 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.21 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764489 c.1120C>T synonymous_variant 0.23 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.37 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.36 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 765055 c.1686C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765292 c.1923G>C synonymous_variant 0.29 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.3 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.3 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.21 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.21 rifampicin Uncertain significance
rpoC 765346 c.1977C>G synonymous_variant 0.18 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765364 c.1995G>A synonymous_variant 0.17 rifampicin
rpoC 765383 p.Met672Leu missense_variant 0.22 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.24 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.24 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.44 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.41 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.41 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.44 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.51 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.41 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.29 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.39 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.33 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.33 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.47 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.44 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.44 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.44 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.46 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.53 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.53 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.47 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.5 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.67 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.64 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.64 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.59 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.58 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.56 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.32 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.32 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.39 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.39 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.43 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.43 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.45 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.45 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.37 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.22 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.22 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.26 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.29 rifampicin
rpoC 766673 p.Gly1102Asn missense_variant 0.29 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.41 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.38 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.49 rifampicin
rpoC 766795 c.3426C>T synonymous_variant 0.39 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.38 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.27 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.44 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.38 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.38 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.52 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.67 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.48 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.46 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775975 c.2506T>C synonymous_variant 0.28 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.3 clofazimine
bedaquiline
mmpL5 777191 c.1290C>G synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 777194 c.1287A>G synonymous_variant 0.19 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.41 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.42 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.48 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.5 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.45 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.45 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.42 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.34 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.39 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.4 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.43 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.41 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.39 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.38 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.35 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.4 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.47 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.4 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.39 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.35 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.36 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.39 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.4 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.39 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.41 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.48 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.55 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.23 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.29 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.29 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.27 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.26 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.26 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.26 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.38 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.34 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.41 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.38 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.39 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.33 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.32 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.27 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.32 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.24 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.23 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.24 linezolid
rplC 800814 c.6A>G synonymous_variant 0.33 linezolid
rplC 800817 c.9A>T synonymous_variant 0.31 linezolid
rplC 800844 c.36T>C synonymous_variant 0.27 linezolid
rplC 800889 c.81C>G synonymous_variant 0.18 linezolid
rplC 800892 c.84G>C synonymous_variant 0.18 linezolid
rplC 801147 c.339T>C synonymous_variant 0.2 linezolid
rplC 801150 c.342G>C synonymous_variant 0.22 linezolid
rplC 801153 c.345G>C synonymous_variant 0.24 linezolid
rplC 801156 c.348T>A synonymous_variant 0.29 linezolid
rplC 801168 c.360C>G synonymous_variant 0.37 linezolid
rplC 801171 c.363A>G synonymous_variant 0.37 linezolid
rplC 801174 c.366T>C synonymous_variant 0.37 linezolid
rplC 801180 c.372C>G synonymous_variant 0.43 linezolid
rplC 801195 c.387G>C synonymous_variant 0.45 linezolid
rplC 801207 c.399C>T synonymous_variant 0.5 linezolid
rplC 801300 c.492C>G synonymous_variant 0.38 linezolid
rplC 801357 c.549T>C synonymous_variant 0.34 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.4 linezolid
fbiC 1303530 c.600G>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303534 p.Ser202Ala missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303539 c.609G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303545 c.615A>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303909 p.Pro327Ser missense_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.45 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.48 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.41 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.44 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.46 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.45 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.4 clofazimine
pretomanid
delamanid
sigE 1364898 c.486C>T synonymous_variant 0.47 pyrazinamide
sigE 1364904 p.Asp164Glu missense_variant 0.47 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.23 pyrazinamide
atpE 1460882 c.-163T>C upstream_gene_variant 0.27 bedaquiline
atpE 1460894 c.-151A>G upstream_gene_variant 0.25 bedaquiline
atpE 1460897 c.-148A>C upstream_gene_variant 0.25 bedaquiline
atpE 1460900 c.-145T>C upstream_gene_variant 0.26 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.45 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472045 n.200T>A non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.43 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.44 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.39 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473668 n.11C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1473677 n.20C>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.56 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473945 n.288T>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473946 n.289A>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.41 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.41 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.44 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.34 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 0.61 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.35 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.36 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
fabG1 1673710 p.Leu91Ile missense_variant 0.2 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.2 ethionamide
isoniazid
fabG1 1673905 p.Ser156Ala missense_variant 0.18 ethionamide
isoniazid
inhA 1673916 c.-286A>C upstream_gene_variant 0.27 ethionamide
isoniazid
fabG1 1673917 p.Val160Leu missense_variant 0.27 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.29 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.29 ethionamide
isoniazid
inhA 1673946 c.-256C>G upstream_gene_variant 0.31 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1673985 c.-217C>G upstream_gene_variant 0.28 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.32 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.31 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674552 c.351C>G synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.31 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.4 ethionamide
isoniazid
inhA 1674597 c.396G>A synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.39 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.49 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.39 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.47 ethionamide
isoniazid
inhA 1674672 c.471C>G synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674726 c.525G>A synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674822 c.621C>G synonymous_variant 0.31 ethionamide
isoniazid
inhA 1674828 c.627G>A synonymous_variant 0.35 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.43 ethionamide
isoniazid
rpsA 1833589 c.48A>T synonymous_variant 0.28 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.36 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.52 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.52 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.52 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.52 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.5 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.45 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.48 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.48 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.49 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.52 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.52 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.54 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.51 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.52 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.55 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.53 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.59 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.62 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.48 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.43 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.38 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834510 c.969C>T synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
rpsA 1834513 c.972C>G synonymous_variant 0.44 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.44 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.38 pyrazinamide
rpsA 1834684 c.1143C>T synonymous_variant 0.53 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.53 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.34 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.35 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.39 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.35 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.31 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.3 pyrazinamide
tlyA 1917951 c.12T>C synonymous_variant 0.3 capreomycin
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1917975 c.36C>G synonymous_variant 0.35 capreomycin
tlyA 1917981 c.42G>C synonymous_variant 0.35 capreomycin
tlyA 1917990 c.51G>C synonymous_variant 0.39 capreomycin
tlyA 1917993 c.54A>G synonymous_variant 0.39 capreomycin Not assoc w R - Interim
tlyA 1917996 c.57A>G synonymous_variant 0.37 capreomycin
tlyA 1918002 c.63A>G synonymous_variant 0.39 capreomycin
bacA 2064972 c.-244T>C upstream_gene_variant 0.64 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.55 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.55 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
ndh 2102671 c.372T>G synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102680 c.363T>C synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102686 c.357G>C synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2102695 c.348C>T synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2102700 c.343C>T synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2102710 c.333C>T synonymous_variant 0.26 ethionamide
delamanid
isoniazid
Rv1979c 2223051 p.Glu38Asp missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518190 p.Ser26Ala missense_variant 0.26 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.25 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.25 isoniazid
kasA 2518459 c.345T>C synonymous_variant 0.26 isoniazid
kasA 2518462 c.348A>C synonymous_variant 0.3 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.31 isoniazid
kasA 2518474 c.360G>A synonymous_variant 0.32 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.32 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.32 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.38 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.38 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.36 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.34 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.42 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.31 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.29 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.32 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.33 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.33 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.35 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.45 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.45 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.41 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.32 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.32 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.3 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.29 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.42 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.42 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.36 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.38 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.35 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.33 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.29 isoniazid
kasA 2518919 c.805_807delGGTinsAC frameshift_variant&missense_variant 0.7 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.26 isoniazid
kasA 2519108 c.994_996delGATinsCG frameshift_variant&missense_variant 0.27 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.33 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.38 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.32 isoniazid
ahpC 2726528 c.336C>G synonymous_variant 0.47 isoniazid
ahpC 2726540 c.348C>G synonymous_variant 0.39 isoniazid
ahpC 2726543 c.351A>G synonymous_variant 0.39 isoniazid
ahpC 2726546 c.354C>G synonymous_variant 0.39 isoniazid
ahpC 2726551 p.Gln120Leu missense_variant 0.37 isoniazid
ahpC 2726556 c.364_366delGCAinsAC frameshift_variant&missense_variant 0.35 isoniazid Uncertain significance
ahpC 2726564 c.372C>G synonymous_variant 0.35 isoniazid Not assoc w R - Interim
ahpC 2726591 c.399C>G synonymous_variant 0.35 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.4 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.4 isoniazid
ahpC 2726601 p.Ile137Leu missense_variant 0.4 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.31 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.31 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.34 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.28 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.26 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.26 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.26 isoniazid Not assoc w R - Interim
ahpC 2726687 c.495C>G synonymous_variant 0.28 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.28 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.26 isoniazid
ahpC 2726717 c.525A>G synonymous_variant 0.2 isoniazid
folC 2747289 p.Pro104Ala missense_variant 0.32 para-aminosalicylic_acid
folC 2747290 c.309A>G synonymous_variant 0.33 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.35 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.43 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.43 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.43 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.48 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.44 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.44 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.44 para-aminosalicylic_acid
folC 2747394 p.Ile69Val missense_variant 0.4 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.4 para-aminosalicylic_acid
Rv2477c 2783098 c.945C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783107 c.936G>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.41 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.43 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.45 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.44 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.41 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2752c 3064973 p.Ala407Ser missense_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3064974 c.1218T>C synonymous_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065040 c.1152C>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065824 p.Pro123Leu missense_variant 0.96 ethambutol Not assoc w R
moxifloxacin Uncertain significance
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R - Interim
Rv2752c 3066024 c.168T>G synonymous_variant 0.3 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066040 p.Gly51Thr missense_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066042 c.150T>C synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066045 c.147T>C synonymous_variant 0.28 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066054 c.138T>G synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066066 c.126T>C synonymous_variant 0.31 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066075 c.117A>G synonymous_variant 0.29 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066330 c.-139G>C upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066335 c.-144T>C upstream_gene_variant 0.27 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066339 c.-148G>C upstream_gene_variant 0.25 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067457 c.489C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.32 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.28 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.33 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.41 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.43 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.45 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.46 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.45 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.45 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.44 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.47 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.47 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067637 c.309G>A synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 0.26 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.32 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.32 para-aminosalicylic_acid
thyX 3067772 c.174C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067775 c.171C>T synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.39 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.41 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.4 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.43 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625161 c.-251T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.26 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625186 c.-276T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3625189 c.1425A>G synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625195 c.-285A>G upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625518 c.-608T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625525 c.-615G>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.33 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.36 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.27 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.37 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.38 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.44 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.4 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625849 c.-939T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.32 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.31 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.41 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.39 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3626869 c.481C>T synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626876 c.-263A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626945 c.-332C>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3626969 c.381C>T synonymous_variant 0.4 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626972 c.-359A>G upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.36 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrA 3627146 c.204C>T synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627167 c.-554T>C upstream_gene_variant 0.34 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.39 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.41 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.29 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627917 c.-568G>C upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrA 3627920 c.-571A>G upstream_gene_variant 0.4 bedaquiline
rifampicin
fbiB 3642719 c.1185T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
rpoA 3877587 c.921A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.29 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.34 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.33 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.41 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.32 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.43 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.4 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.42 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.34 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.35 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.36 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.33 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.31 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.32 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.34 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877989 c.519A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.28 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.26 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.27 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878055 c.453A>G synonymous_variant 0.23 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.23 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.21 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.19 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.19 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.2 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.21 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.41 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.43 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.5 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.4 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.26 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.29 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.28 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.3 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.37 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.38 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.39 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.42 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.44 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.48 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.47 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.43 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.38 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.37 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.37 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.38 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.38 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.39 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.44 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.41 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.33 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.32 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.36 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.3 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.25 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.27 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.3 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.31 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.35 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.48 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.54 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.56 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.53 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.47 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.3 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 0.82 pyrazinamide Not assoc w R
clpC1 4038302 c.2403C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038308 c.2397G>T synonymous_variant 0.23 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.25 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.32 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.29 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.21 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038695 c.2010C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.24 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.33 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.37 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038974 c.1731T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.26 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039349 c.1356C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.35 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.31 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.32 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.46 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.32 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.38 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.32 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.34 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.4 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.39 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.39 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.45 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.36 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.43 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.34 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.37 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.24 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.32 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.31 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.33 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.28 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.3 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.33 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.28 pyrazinamide
glpK 4138670 c.1086G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.4 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139126 c.630G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139132 c.624A>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139135 c.619_621delGATinsAC frameshift_variant&synonymous_variant 0.27 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4139143 c.613T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139165 c.591A>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139168 c.588T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139177 c.579T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139183 c.573T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139186 c.570G>C synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139195 c.561G>T synonymous_variant 0.21 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139198 c.558C>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139207 c.549T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139601 p.Arg52Gln missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139615 c.141G>A synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139651 c.103_105delCACinsGG frameshift_variant&missense_variant 0.43 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4240677 p.Gly272Ala missense_variant 0.42 ethambutol
embC 4240685 c.823_825delACCinsGT frameshift_variant&missense_variant 0.43 ethambutol
embC 4240693 c.831T>G synonymous_variant 0.48 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.46 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.48 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.41 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.37 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.34 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.29 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.33 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.33 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.3 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.31 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.35 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.33 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.35 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.35 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.35 ethambutol
embC 4241567 p.Ile569Val missense_variant 0.27 ethambutol
embC 4241572 c.1710C>G synonymous_variant 0.28 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.28 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.27 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.27 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.27 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.96 ethambutol Not assoc w R
embA 4244543 c.1311C>G synonymous_variant 0.27 ethambutol
embA 4244547 p.Ile439Val missense_variant 0.27 ethambutol
embA 4244557 p.Arg442Thr missense_variant 0.3 ethambutol
embA 4244582 c.1350T>C synonymous_variant 0.33 ethambutol
embA 4244585 c.1353A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embA 4244611 p.Ala460Gly missense_variant 0.37 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.22 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.32 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.33 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.33 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.38 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.31 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.31 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.31 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.37 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.38 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.4 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.41 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.4 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.41 ethambutol Uncertain significance
embA 4245248 c.2016G>C synonymous_variant 0.41 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.39 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.42 ethambutol Not assoc w R - Interim
embA 4245785 c.2553G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4245833 c.-681G>C upstream_gene_variant 0.18 ethambutol
embB 4245842 c.-672G>C upstream_gene_variant 0.24 ethambutol
embB 4245845 c.-669T>C upstream_gene_variant 0.23 ethambutol
embB 4245851 c.-663G>C upstream_gene_variant 0.22 ethambutol
embB 4245860 c.-654C>G upstream_gene_variant 0.23 ethambutol
embA 4246235 c.3003G>A synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embA 4246242 p.Gln1004Gly missense_variant 0.24 ethambutol
embB 4246250 c.-264G>C upstream_gene_variant 0.26 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.26 ethambutol
embB 4246259 c.-255G>C upstream_gene_variant 0.26 ethambutol
embA 4246264 p.His1011Arg missense_variant 0.28 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.34 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.24 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.25 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.42 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.42 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.44 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.4 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.33 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.31 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.32 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.28 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.28 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.29 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.24 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.24 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.24 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.24 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.34 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.26 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.27 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.31 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.29 ethambutol
embB 4248382 c.1869C>G synonymous_variant 0.25 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.23 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.43 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.42 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.42 ethambutol
embB 4249429 c.2916C>T synonymous_variant 0.39 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.41 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.38 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.35 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.34 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.33 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.32 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 0.22 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 0.23 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.24 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.24 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.28 ethambutol
aftB 4269206 c.-370C>T upstream_gene_variant 0.28 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.28 ethambutol
ubiA 4269222 c.612T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
aftB 4269242 c.-406C>T upstream_gene_variant 0.29 ethambutol
ubiA 4269243 p.His197Gln missense_variant 0.29 ethambutol
aftB 4269249 c.-413G>A upstream_gene_variant 0.29 ethambutol
aftB 4269258 c.-422C>T upstream_gene_variant 0.29 ethambutol
ubiA 4269271 p.Val188Ala missense_variant 0.77 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R