TB-Profiler result

Run: ERR4814734
Summary

Run ID: ERR4814734

Sample name:

Date: 2024-10-03T23:58:45.118037

Number of reads: 1093431

Percentage reads mapped: 53.96

Median coverage: 29.5

Strain: lineage1.2.1.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.2.1.1 Indo-Oceanic RD239 0.94
lineage1 Indo-Oceanic RD239 0.96
lineage1.2.1 Indo-Oceanic RD239 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin gid c.518dupA Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gid 4407684 c.518dupA frameshift_variant 1.0 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1254 c.1254T>G synonymous_variant 0.3 isoniazid
dnaA 1266 c.1266A>G synonymous_variant 0.36 isoniazid
dnaA 1275 p.Asp425Glu missense_variant 0.33 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.32 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.29 isoniazid
dnaA 1293 c.1293T>G synonymous_variant 0.3 isoniazid
gyrB 6112 p.Met291Ile missense_variant 0.93 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6142 c.903G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6148 c.909C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6175 c.936G>A synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 6187 c.948C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6196 c.957C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrB 6203 c.964_966delAGCinsTCG synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 6215 p.Ser326Thr missense_variant 0.29 levofloxacin
moxifloxacin
gyrB 6242 p.Arg335Lys missense_variant 0.28 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrB 6253 c.1014G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.37 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>T synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.37 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6324 c.1085_1086insGGCC frameshift_variant 0.34 levofloxacin Uncertain significance
moxifloxacin
gyrB 6327 c.1090_1093delGAAC frameshift_variant 0.36 levofloxacin Uncertain significance
moxifloxacin
gyrA 6362 c.-940_-938delTTGinsCTC upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6367 c.-935C>T upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrB 6398 p.Val387Ile missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6409 c.-893A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6715 c.1476C>T synonymous_variant 0.15 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6745 c.1506T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6769 c.-533C>T upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6775 c.1536G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6778 c.-524C>T upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Ser missense_variant 0.25 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.19 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 7123 c.-179C>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7135 c.-167G>A upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 7138 c.-164G>A upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7156 c.1917C>T synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>G upstream_gene_variant 0.53 levofloxacin
moxifloxacin
gyrA 7177 c.-125G>A upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 7189 c.-113C>T upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrB 7198 c.1959C>T synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7433 c.132G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7436 c.135C>T synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7442 c.141G>C synonymous_variant 0.46 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7460 c.159C>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7463 c.162G>C synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.5 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.49 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.45 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.43 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.45 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>A synonymous_variant 0.47 levofloxacin
moxifloxacin
gyrA 7523 c.222C>A synonymous_variant 0.42 levofloxacin
moxifloxacin
gyrA 7526 c.225G>T synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.43 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7799 c.498A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7841 c.540C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7847 c.546G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7886 c.585T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7889 c.588G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7890 c.589C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8321 c.1020C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8375 c.1074G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8401 p.Asp367Ala missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8452 p.Ala384Val missense_variant 0.8 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8456 c.1155C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8477 c.1176C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8952 p.Gln551Ala missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8967 p.Ala556Asn missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9017 c.1716C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9224 c.1923C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9236 c.1935G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9260 c.1959G>C synonymous_variant 0.76 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9341 c.2040C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9353 c.2052G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9356 c.2055G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
Rv0010c 13189 p.Val124Met missense_variant 1.0 isoniazid Uncertain significance
Rv0010c 13298 p.Ile87Met missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575695 c.348C>G synonymous_variant 0.27 isoniazid Not assoc w R - Interim
ethionamide
mshA 575704 c.357T>C synonymous_variant 0.3 isoniazid
ethionamide
mshA 575705 c.358T>C synonymous_variant 0.29 isoniazid
ethionamide
mshA 575728 c.381C>A synonymous_variant 0.39 isoniazid
ethionamide
mshA 575734 c.387T>G synonymous_variant 0.38 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.35 isoniazid
ethionamide
mshA 575744 p.Ala133Thr missense_variant 0.38 isoniazid Uncertain significance
ethionamide
mshA 575749 c.402C>G synonymous_variant 0.36 isoniazid
ethionamide
mshA 575756 c.409C>T synonymous_variant 0.36 isoniazid
ethionamide
mshA 575771 p.Val142Thr missense_variant 0.28 isoniazid
ethionamide
mshA 575779 c.432A>G synonymous_variant 0.28 isoniazid
ethionamide
mshA 575782 c.435G>C synonymous_variant 0.26 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.27 isoniazid
ethionamide
mshA 575788 c.441C>T synonymous_variant 0.29 isoniazid
ethionamide
mshA 575795 p.Ile150Val missense_variant 0.35 isoniazid
ethionamide
mshA 575800 c.453G>C synonymous_variant 0.34 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.29 isoniazid
ethionamide
ccsA 620385 c.495G>C synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.18 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620427 c.537C>G synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620436 c.546T>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620439 c.549T>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620721 c.831G>C synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620724 c.834C>T synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620730 c.840C>T synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620736 c.846G>C synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620742 c.852G>A synonymous_variant 0.21 kanamycin
capreomycin
amikacin
Rv0565c 657530 c.-60G>A upstream_gene_variant 1.0 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
nusG 734116 c.-138T>C upstream_gene_variant 1.0 rifampicin Not assoc w R
nusG 734451 c.198G>C synonymous_variant 0.2 rifampicin
nusG 734454 c.201A>G synonymous_variant 0.2 rifampicin
nusG 734460 c.207G>C synonymous_variant 0.19 rifampicin
nusG 734472 c.219T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.18 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.19 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.21 rifampicin
rpoB 760151 c.345G>A synonymous_variant 0.22 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.39 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.4 rifampicin
rpoB 760325 c.519G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760331 c.525G>C synonymous_variant 0.38 rifampicin
rpoB 760334 c.528G>T synonymous_variant 0.37 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Ser missense_variant 0.28 rifampicin Uncertain significance
rpoB 760361 c.555T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.28 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.29 rifampicin Uncertain significance
rpoB 760407 p.Ser201Gly missense_variant 0.29 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.21 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760532 c.726T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.19 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760585 p.Asn260Ser missense_variant 0.16 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.17 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.2 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760748 c.942C>G synonymous_variant 0.34 rifampicin
rpoB 760751 c.945G>C synonymous_variant 0.34 rifampicin
rpoB 760755 p.His317Asn missense_variant 0.35 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.36 rifampicin
rpoB 760764 p.Glu320Gln missense_variant 0.38 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.32 rifampicin
rpoB 760784 c.978G>C synonymous_variant 0.32 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.32 rifampicin
rpoB 760916 c.1110C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.19 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.21 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>T synonymous_variant 0.2 rifampicin
rpoB 760985 c.1179G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.26 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.26 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761333 c.1527G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>T synonymous_variant 0.2 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.21 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761367 p.Glu521Gln missense_variant 0.23 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.26 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.28 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761537 c.1731C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761552 c.1746G>T synonymous_variant 0.24 rifampicin
rpoB 761555 c.1749G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.26 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761633 c.1827G>A synonymous_variant 0.26 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761666 c.1860G>C synonymous_variant 0.2 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.22 rifampicin
rpoB 761705 c.1899C>T synonymous_variant 0.19 rifampicin
rpoB 761712 p.Val636Ile missense_variant 0.19 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.2 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.21 rifampicin
rpoB 761892 p.Ile696Val missense_variant 0.21 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.25 rifampicin
rpoB 762002 c.2196C>G synonymous_variant 0.26 rifampicin
rpoB 762038 c.2232C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.37 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.4 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.45 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.38 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.38 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762239 c.2433G>A synonymous_variant 0.35 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.26 rifampicin
rpoB 762293 c.2487T>G synonymous_variant 0.28 rifampicin
rpoC 762839 c.-531G>A upstream_gene_variant 0.25 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.33 rifampicin Uncertain significance
rpoC 762911 c.-459C>T upstream_gene_variant 0.37 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.39 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 763004 c.3198G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763007 c.3201C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763022 c.-348C>G upstream_gene_variant 0.44 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.56 rifampicin Not assoc w R
rpoB 763053 c.3247T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.4 rifampicin
rpoB 763088 c.3282C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.43 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763133 c.-237G>C upstream_gene_variant 0.38 rifampicin
rpoB 763136 c.3330C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763160 c.-210G>T upstream_gene_variant 0.33 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.28 rifampicin
rpoC 763193 c.-177C>T upstream_gene_variant 0.2 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.17 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.17 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>C synonymous_variant 0.16 rifampicin
rpoC 763414 c.45T>C synonymous_variant 0.16 rifampicin
rpoC 763423 p.Glu18Asp missense_variant 0.17 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCGT synonymous_variant 0.17 rifampicin
rpoC 763433 p.Gln22Asn missense_variant 0.17 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.16 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763465 c.96G>A synonymous_variant 0.19 rifampicin
rpoC 763486 c.117T>G synonymous_variant 0.15 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763621 c.252C>G synonymous_variant 0.25 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>A synonymous_variant 0.21 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763858 c.489A>G synonymous_variant 0.24 rifampicin
rpoC 763861 c.492C>T synonymous_variant 0.24 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.25 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.27 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.26 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.7 rifampicin Not assoc w R
rpoC 763886 c.517C>A synonymous_variant 0.7 rifampicin Not assoc w R
rpoC 763891 c.522G>C synonymous_variant 0.28 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.28 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763921 c.552G>C synonymous_variant 0.25 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763940 p.Ala191Ser missense_variant 0.25 rifampicin Uncertain significance
rpoC 763945 c.576T>C synonymous_variant 0.24 rifampicin
rpoC 763947 p.Ala193Val missense_variant 0.26 rifampicin Uncertain significance
rpoC 763951 c.582G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.25 rifampicin
rpoC 764153 p.Gln262Lys missense_variant 0.15 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764293 c.924G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764297 p.Met310Leu missense_variant 0.34 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.29 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764374 c.1005C>T synonymous_variant 0.21 rifampicin
rpoC 764380 c.1011G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.33 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.32 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.33 rifampicin
rpoC 764455 c.1086G>T synonymous_variant 0.33 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764485 c.1116G>C synonymous_variant 0.33 rifampicin
rpoC 764491 c.1122G>T synonymous_variant 0.33 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.3 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764692 c.1323C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764701 c.1332C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764719 c.1350G>A synonymous_variant 0.33 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.42 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764851 c.1482C>T synonymous_variant 0.38 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.16 rifampicin Uncertain significance
rpoC 765403 c.2034G>C synonymous_variant 0.18 rifampicin
rpoC 765404 p.Leu679Lys missense_variant 0.18 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.18 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.17 rifampicin
rpoC 765425 p.Lys686Glu missense_variant 0.2 rifampicin
rpoC 765445 c.2076G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765452 p.Ala695Arg missense_variant 0.25 rifampicin
rpoC 765466 c.2097C>T synonymous_variant 0.29 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 0.31 rifampicin Uncertain significance
rpoC 765496 c.2127C>G synonymous_variant 0.29 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765772 c.2403C>G synonymous_variant 0.24 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.23 rifampicin
rpoC 765779 p.Asp804Lys missense_variant 0.23 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.25 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.25 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.27 rifampicin
rpoC 765800 p.Phe811Leu missense_variant 0.3 rifampicin
rpoC 765814 c.2445A>C synonymous_variant 0.3 rifampicin
rpoC 765817 c.2448G>C synonymous_variant 0.3 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765868 c.2499G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>C synonymous_variant 0.3 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.29 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.26 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765895 c.2526G>A synonymous_variant 0.23 rifampicin
rpoC 765899 c.2530C>T synonymous_variant 0.22 rifampicin
rpoC 765904 c.2535C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765908 c.2539C>T synonymous_variant 0.23 rifampicin
rpoC 765934 c.2565C>T synonymous_variant 0.16 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.16 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765952 c.2583G>C synonymous_variant 0.18 rifampicin
rpoC 765961 c.2592G>T synonymous_variant 0.18 rifampicin
rpoC 765962 c.2593T>C synonymous_variant 0.18 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766618 c.3249G>T synonymous_variant 0.29 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.27 rifampicin
rpoC 766634 p.Phe1089Leu missense_variant 0.26 rifampicin
rpoC 766638 p.Lys1090Thr missense_variant 0.26 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.26 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.27 rifampicin
rpoC 766658 p.Arg1097Gly missense_variant 0.27 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.23 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.24 rifampicin
rpoC 766675 c.3306C>T synonymous_variant 0.26 rifampicin
rpoC 766690 c.3321G>C synonymous_variant 0.25 rifampicin
rpoC 766694 p.Gln1109Asp missense_variant 0.25 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.31 rifampicin
rpoC 766717 c.3348C>G synonymous_variant 0.31 rifampicin
rpoC 766720 c.3351C>T synonymous_variant 0.33 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.33 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.28 rifampicin
rpoC 766741 c.3372G>C synonymous_variant 0.29 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766771 c.3402G>C synonymous_variant 0.27 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.27 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.28 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766801 c.3432C>T synonymous_variant 0.34 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767068 c.3699G>T synonymous_variant 0.3 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767105 p.Asn1246Gln missense_variant 0.3 rifampicin Uncertain significance
rpoC 767119 c.3750A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767162 p.Asn1265Ala missense_variant 0.31 rifampicin
rpoC 767167 c.3798C>T synonymous_variant 0.29 rifampicin
rpoC 767174 p.Asn1269Asp missense_variant 0.25 rifampicin
rpoC 767180 p.Ala1271Gln missense_variant 0.25 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775746 p.Met912Thr missense_variant 1.0 bedaquiline Uncertain significance
clofazimine
mmpL5 775856 c.2625T>C synonymous_variant 0.23 bedaquiline
clofazimine
mmpL5 775862 c.2619G>C synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 775904 c.2577G>A synonymous_variant 0.26 bedaquiline
clofazimine
mmpL5 775915 p.Ala856Ser missense_variant 0.24 bedaquiline
clofazimine
mmpL5 775951 c.2530C>T synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 776018 c.2463G>C synonymous_variant 0.31 bedaquiline
clofazimine
mmpL5 776030 c.2451G>T synonymous_variant 0.33 bedaquiline
clofazimine
mmpL5 776039 c.2442C>A synonymous_variant 0.3 bedaquiline
clofazimine
mmpL5 776053 c.2428T>C synonymous_variant 0.37 bedaquiline
clofazimine
mmpL5 776075 c.2406C>G synonymous_variant 0.35 bedaquiline
clofazimine
mmpL5 776078 c.2403C>A synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 776084 c.2397C>G synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 776087 c.2394C>G synonymous_variant 0.3 bedaquiline
clofazimine
mmpL5 776090 c.2391C>T synonymous_variant 0.2 bedaquiline
clofazimine
mmpL5 776096 c.2385C>G synonymous_variant 0.34 bedaquiline
clofazimine
mmpL5 776100 p.Thr794Leu missense_variant 1.0 bedaquiline
clofazimine
mmpL5 776107 c.2374C>T synonymous_variant 0.17 bedaquiline
clofazimine
mmpL5 776129 c.2352C>G synonymous_variant 0.33 bedaquiline
clofazimine
mmpL5 776155 c.2326T>C synonymous_variant 0.25 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781655 c.96T>C synonymous_variant 0.17 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.18 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.22 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.2 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.18 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.17 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.15 streptomycin
rpsL 781737 p.Gln60Gly missense_variant 0.16 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.16 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.17 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.18 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.18 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.19 streptomycin Not assoc w R - Interim
rpsL 781769 c.210G>A synonymous_variant 0.18 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.25 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.23 streptomycin
rpsL 781829 c.270G>T synonymous_variant 0.3 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.28 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.28 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.26 streptomycin
rpsL 781859 c.300T>G synonymous_variant 0.3 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.34 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.36 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.39 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.38 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.36 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.32 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.3 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.31 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.25 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 1.0 linezolid Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1304511 c.1581C>G synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1304520 c.1590A>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304523 c.1593G>A synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304526 c.1596T>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304533 c.1603T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304538 c.1608C>T synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304562 c.1632G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304567 p.Phe546Tyr missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304571 c.1641G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304595 c.1665C>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
sigE 1364697 c.285G>A synonymous_variant 0.16 pyrazinamide
sigE 1364709 c.297T>C synonymous_variant 0.21 pyrazinamide
sigE 1364715 c.303G>C synonymous_variant 0.21 pyrazinamide
sigE 1364718 c.306C>G synonymous_variant 0.22 pyrazinamide
sigE 1364721 c.309C>G synonymous_variant 0.22 pyrazinamide
sigE 1364724 c.312C>T synonymous_variant 0.23 pyrazinamide
sigE 1364742 c.330A>G synonymous_variant 0.26 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.28 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.28 pyrazinamide
sigE 1364778 c.366G>A synonymous_variant 0.3 pyrazinamide
sigE 1364781 c.369G>C synonymous_variant 0.31 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.31 pyrazinamide
sigE 1364790 c.378T>C synonymous_variant 0.33 pyrazinamide
embR 1417019 p.Cys110Tyr missense_variant 1.0 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 1.0 ethambutol
atpE 1460853 c.-192T>G upstream_gene_variant 1.0 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.18 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.18 bedaquiline
atpE 1461224 c.180T>G synonymous_variant 0.17 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.46 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTC non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.48 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.46 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
inhA 1673784 c.-418G>A upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673787 c.-415G>A upstream_gene_variant 0.16 isoniazid Uncertain significance
ethionamide
inhA 1673799 c.-403T>G upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673802 c.-400A>G upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673808 c.-394A>C upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673811 c.-391G>A upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673829 c.-373C>G upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673830 c.-372_-370delAAAinsCGT upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673838 c.-364T>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673841 c.-361A>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673844 c.-358G>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673847 c.-355A>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1673853 c.-349A>C upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673870 c.-332_-331delGCinsTG upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673901 c.-301A>G upstream_gene_variant 0.2 isoniazid
ethionamide
inhA 1673905 c.-297T>G upstream_gene_variant 0.19 isoniazid
ethionamide
rpsA 1833685 c.144G>T synonymous_variant 0.15 pyrazinamide
rpsA 1833694 c.153G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.15 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833793 c.252C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833808 c.267G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.26 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.33 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.33 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.27 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.42 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.42 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.38 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.35 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.35 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834067 c.526C>T synonymous_variant 0.32 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.28 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
rpsA 1834297 c.756C>T synonymous_variant 0.33 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.32 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1834361 c.820T>C synonymous_variant 0.41 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.45 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.45 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.44 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.29 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834606 c.1065C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.22 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.29 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834756 c.1215G>A synonymous_variant 0.24 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.23 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.24 pyrazinamide
tsnR 1853974 c.369C>T synonymous_variant 1.0 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
bacA 2063487 c.1242G>A synonymous_variant 1.0 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168533 p.Val694Leu missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2290129 c.-888C>A upstream_gene_variant 1.0 pyrazinamide
kasA 2517941 c.-174C>G upstream_gene_variant 0.21 isoniazid
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2519035 c.921C>T synonymous_variant 1.0 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 1.0 isoniazid
ahpC 2726639 c.447C>G synonymous_variant 0.15 isoniazid
ahpC 2726669 c.477T>C synonymous_variant 0.16 isoniazid
ahpC 2726675 c.483A>G synonymous_variant 0.15 isoniazid
ahpC 2726681 c.489A>G synonymous_variant 0.18 isoniazid
ahpC 2726684 c.492G>T synonymous_variant 0.18 isoniazid
ahpC 2726693 c.501C>G synonymous_variant 0.18 isoniazid
ahpC 2726696 c.504C>G synonymous_variant 0.17 isoniazid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782501 c.1542T>C synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2782534 c.1509C>T synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
fbiD 3339417 c.300A>G synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
Rv3083 3448714 p.Asp71His missense_variant 1.0 ethionamide Uncertain significance
Rv3083 3448835 p.Ser111Ile missense_variant 1.0 ethionamide Uncertain significance
lpqB 3624486 p.Asp142Gly missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
fbiA 3640557 c.15T>C synonymous_variant 0.95 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
rpoA 3877647 c.861C>T synonymous_variant 0.15 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.15 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.22 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.2 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877878 c.630G>A synonymous_variant 0.2 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.21 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.29 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877965 c.543C>G synonymous_variant 0.25 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.24 rifampicin Uncertain significance
rpoA 3878103 c.405A>G synonymous_variant 0.21 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.32 rifampicin Uncertain significance
rpoA 3878145 c.363C>G synonymous_variant 0.31 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.34 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.35 rifampicin
rpoA 3878184 c.324C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.24 rifampicin
rpoA 3878250 c.258C>G synonymous_variant 0.25 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.26 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.25 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>C synonymous_variant 0.18 rifampicin
clpC1 4038551 c.2154C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038563 c.2142C>T synonymous_variant 0.24 pyrazinamide
clpC1 4038587 c.2118C>G synonymous_variant 0.29 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.32 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.34 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.3 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.32 pyrazinamide
clpC1 4038660 c.2044_2045delTCinsAG synonymous_variant 0.3 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038671 c.2034T>A synonymous_variant 0.29 pyrazinamide
clpC1 4038674 c.2031C>T synonymous_variant 0.3 pyrazinamide
clpC1 4038679 p.Pro676Ala missense_variant 0.3 pyrazinamide
clpC1 4038683 c.2022T>G synonymous_variant 0.3 pyrazinamide
clpC1 4038695 c.2010C>G synonymous_variant 0.35 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038721 c.1984C>T synonymous_variant 0.33 pyrazinamide
clpC1 4038725 c.1980C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.24 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.29 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.45 pyrazinamide Not assoc w R - Interim
clpC1 4038884 c.1821C>T synonymous_variant 0.39 pyrazinamide
clpC1 4038890 c.1815G>A synonymous_variant 0.38 pyrazinamide
clpC1 4038905 c.1800A>C synonymous_variant 0.39 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.45 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.45 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.47 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.49 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.47 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.47 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.5 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.45 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.31 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.31 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039241 c.1464G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039280 c.1425G>T synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4039283 c.1422C>T synonymous_variant 0.35 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039310 c.1395A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039313 c.1392C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039320 p.Ala462Gly missense_variant 0.28 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.26 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Gly missense_variant 0.2 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039673 c.1032G>A synonymous_variant 0.39 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.39 pyrazinamide
clpC1 4039694 c.1011G>T synonymous_variant 0.47 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.4 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039766 c.939T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039934 c.771G>T synonymous_variant 0.27 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.38 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.41 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.4 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.41 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.39 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.21 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040486 c.219G>A synonymous_variant 0.19 pyrazinamide
clpC1 4040495 c.210C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040517 p.Val63Ala missense_variant 0.78 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
embC 4240167 c.307_309delACG conservative_inframe_deletion 1.0 ethambutol
embC 4240759 c.897C>G synonymous_variant 0.23 ethambutol
embC 4240777 c.915G>A synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.24 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.24 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.22 ethambutol
embC 4241042 p.Asn394Asp missense_variant 0.94 ethambutol Not assoc w R
embA 4244420 c.1188G>C synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245969 p.Pro913Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4248515 p.Val668Ile missense_variant 1.0 ethambutol Not assoc w R - Interim
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
ethA 4327360 c.114G>C synonymous_variant 1.0 ethionamide Not assoc w R - Interim
whiB6 4338361 p.Arg54Gln missense_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 1.0 streptomycin Not assoc w R