TB-Profiler result

Run: SRR11462861
Summary

Run ID: SRR11462861

Sample name:

Date: 2024-10-04T05:44:06.650929

Number of reads: 730252

Percentage reads mapped: 48.68

Median coverage: 31.0

Strain: La1.8.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.8 M.bovis None 1.0
La1.8.1 M.bovis None 1.0
La1 M.bovis None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide pncA p.His57Asp Assoc w R
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
pncA 2289073 p.His57Asp missense_variant 1.0 pyrazinamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 467 p.His156Arg missense_variant 1.0 isoniazid Not assoc w R
gyrB 5752 c.513G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6406 c.1167C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6446 p.Ala403Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8285 c.984C>T synonymous_variant 0.98 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8990 c.1689C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9018 p.Gln573Lys missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9217 p.Asp639Ala missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13197 p.Thr121Ser missense_variant 1.0 isoniazid Not assoc w R
Rv0010c 13228 c.330delG frameshift_variant 1.0 isoniazid Uncertain significance
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
rpoB 760184 c.378A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.2 rifampicin
rpoB 760233 c.427_429delAGTinsTCG synonymous_variant 0.21 rifampicin
rpoB 760241 c.435G>C synonymous_variant 0.21 rifampicin
rpoB 760244 c.438G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.23 rifampicin
rpoB 760508 c.702G>C synonymous_variant 0.3 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.3 rifampicin
rpoB 760514 c.708C>G synonymous_variant 0.3 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Leu missense_variant 0.33 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760553 c.747C>G synonymous_variant 0.35 rifampicin
rpoB 760565 c.759A>C synonymous_variant 0.31 rifampicin
rpoB 760568 c.762G>C synonymous_variant 0.31 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.31 rifampicin
rpoB 760589 c.783C>G synonymous_variant 0.26 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.26 rifampicin
rpoB 760611 c.805_807delTTGinsCTC synonymous_variant 0.25 rifampicin
rpoB 761126 c.1320G>C synonymous_variant 0.25 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.24 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.24 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.23 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.23 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762156 p.Val784Ile missense_variant 0.23 rifampicin
rpoB 762170 c.2364C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.3 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762251 c.2445G>C synonymous_variant 0.22 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.22 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.23 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762989 c.3183G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.31 rifampicin
rpoC 763022 c.-348C>G upstream_gene_variant 0.29 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763053 c.-317_-315delTTGinsCTC upstream_gene_variant 0.27 rifampicin
rpoC 763067 c.-303C>G upstream_gene_variant 0.21 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763074 p.Thr1090Val missense_variant 0.22 rifampicin
rpoB 763088 c.3282C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>C synonymous_variant 0.29 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>G synonymous_variant 0.3 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764656 c.1287C>G synonymous_variant 0.27 rifampicin
rpoC 764662 c.1293G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764665 c.1296C>G synonymous_variant 0.28 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.22 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764854 c.1485G>C synonymous_variant 0.21 rifampicin
rpoC 764872 c.1503A>T synonymous_variant 0.18 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.17 rifampicin
rpoC 764887 c.1518G>T synonymous_variant 0.19 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.19 rifampicin
rpoC 764902 c.1533C>G synonymous_variant 0.19 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.2 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.2 rifampicin Uncertain significance
rpoC 764917 c.1548G>C synonymous_variant 0.2 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.25 rifampicin
rpoC 764948 c.1579_1581delTTGinsCTC synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764953 c.1584G>C synonymous_variant 0.23 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.17 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.2 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>T synonymous_variant 0.2 rifampicin
rpoC 765085 c.1716T>C synonymous_variant 0.21 rifampicin
rpoC 765089 c.1720_1722delTTGinsCTC synonymous_variant 0.21 rifampicin
rpoC 765100 c.1731G>C synonymous_variant 0.21 rifampicin
rpoC 765103 c.1734G>T synonymous_variant 0.21 rifampicin
rpoC 766981 c.3612T>G synonymous_variant 0.2 rifampicin
rpoC 766990 c.3621G>C synonymous_variant 0.2 rifampicin
rpoC 767002 c.3633G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>C synonymous_variant 0.22 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.22 rifampicin
rpoC 767017 c.3648C>G synonymous_variant 0.22 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781760 c.201T>C synonymous_variant 0.18 streptomycin
rpsL 781769 c.210G>A synonymous_variant 0.21 streptomycin
rpsL 781772 c.213C>T synonymous_variant 0.21 streptomycin Not assoc w R - Interim
rpsL 781781 c.222G>T synonymous_variant 0.23 streptomycin
rpsL 781802 c.243G>C synonymous_variant 0.2 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.2 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.22 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.22 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.22 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.26 streptomycin
rpsL 781832 c.273T>G synonymous_variant 0.26 streptomycin
rpsL 781838 c.279G>T synonymous_variant 0.24 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.22 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.25 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.26 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.2 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.2 streptomycin
rpsL 781901 c.342C>G synonymous_variant 0.21 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.21 streptomycin
rpsL 781916 c.357T>G synonymous_variant 0.22 streptomycin
rplC 800525 c.-284C>T upstream_gene_variant 0.24 linezolid
rplC 800537 c.-272C>G upstream_gene_variant 0.29 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.3 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.32 linezolid
rplC 800549 c.-260G>T upstream_gene_variant 0.32 linezolid
rplC 800552 c.-257G>T upstream_gene_variant 0.32 linezolid
rplC 800555 c.-254C>G upstream_gene_variant 0.32 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.32 linezolid
rplC 800573 c.-236C>G upstream_gene_variant 0.3 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.3 linezolid
rplC 800585 c.-224T>C upstream_gene_variant 0.3 linezolid
rplC 800589 c.-220A>C upstream_gene_variant 0.32 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.29 linezolid
rplC 800597 c.-212A>C upstream_gene_variant 0.28 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.26 linezolid
rplC 800603 c.-206G>C upstream_gene_variant 0.25 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.27 linezolid
rplC 800618 c.-191T>G upstream_gene_variant 0.26 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.28 linezolid
rplC 800645 c.-164C>T upstream_gene_variant 0.27 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.27 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.26 linezolid
rplC 800672 c.-137G>C upstream_gene_variant 0.22 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.22 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.22 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.22 linezolid
rplC 800715 c.-94_-92delATCinsCTG upstream_gene_variant 0.21 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.21 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.22 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.22 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.24 linezolid
rplC 800762 c.-47T>G upstream_gene_variant 0.21 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
Rv1129c 1254582 c.-48A>G upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 pretomanid
delamanid Uncertain significance
clofazimine Uncertain significance
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471972 n.127T>C non_coding_transcript_exon_variant 0.82 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471981 n.136C>T non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472023 n.178G>T non_coding_transcript_exon_variant 0.82 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472028 n.183_188delACGGGAinsTTCCCC non_coding_transcript_exon_variant 0.88 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472040 n.195_199delTCTTGinsGGGGT non_coding_transcript_exon_variant 0.88 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472067 n.222G>A non_coding_transcript_exon_variant 0.88 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472068 n.223T>C non_coding_transcript_exon_variant 0.88 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472069 n.224G>A non_coding_transcript_exon_variant 0.88 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.86 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.86 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.86 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472313 n.468delGinsCA non_coding_transcript_exon_variant 0.86 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.86 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.86 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472327 n.482G>A non_coding_transcript_exon_variant 0.86 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.86 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472396 n.551A>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.72 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472837 n.992C>T non_coding_transcript_exon_variant 0.72 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472839 n.994C>G non_coding_transcript_exon_variant 0.72 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472843 n.998_999insT non_coding_transcript_exon_variant 0.72 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472857 n.1012A>T non_coding_transcript_exon_variant 0.76 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472858 n.1013G>C non_coding_transcript_exon_variant 0.76 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472864 n.1019C>G non_coding_transcript_exon_variant 0.76 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472872 n.1027G>C non_coding_transcript_exon_variant 0.68 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472874 n.1029C>T non_coding_transcript_exon_variant 0.72 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472876 n.1031G>C non_coding_transcript_exon_variant 0.72 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472878 n.1033G>A non_coding_transcript_exon_variant 0.72 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.72 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473081 n.1236C>G non_coding_transcript_exon_variant 0.82 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473082 n.1237G>C non_coding_transcript_exon_variant 0.82 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.84 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.77 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.77 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>G non_coding_transcript_exon_variant 0.77 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473130 n.1285G>C non_coding_transcript_exon_variant 0.77 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.45 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474180 n.523_524insA non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474674 n.1017A>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474675 n.1018C>A non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474718 n.1061_1062delAGinsGTGAGAA non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474822 n.1165G>C non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475536 n.1879C>A non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475550 n.1893A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475601 n.1945_1950delGGAATA non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475609 n.1954_1955insCTGGT non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475614 n.1957A>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475617 n.1960C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475619 n.1962C>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475622 n.1965G>A non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475627 n.1970G>C non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475633 n.1976G>T non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1475636 n.1979A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475638 n.1981C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1475639 n.1982C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475688 n.2031G>A non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475713 n.2056C>T non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101_2102delACinsG non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1475768 n.2111_2112delGTinsC non_coding_transcript_exon_variant 0.97 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.81 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>G non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476047 n.2390G>C non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476087 n.2430C>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1476091 n.2434_2435insC non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1476110 n.2453G>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.89 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.9 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.9 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.9 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.89 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.66 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.68 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.64 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.62 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833829 c.288A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.32 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.37 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.37 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.38 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.41 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.44 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.41 pyrazinamide
rpsA 1833952 c.411C>T synonymous_variant 0.38 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.37 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.38 pyrazinamide
rpsA 1833973 c.432G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833988 c.447C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.33 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.34 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.33 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834099 c.558C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834108 c.567C>A synonymous_variant 0.25 pyrazinamide
rpsA 1834114 c.573G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834135 c.594G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834151 p.Asn204His missense_variant 0.27 pyrazinamide
rpsA 1834154 p.Asn205Gln missense_variant 0.27 pyrazinamide
rpsA 1834157 c.616T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834162 c.621A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834165 c.624A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834167 c.628_629delAC frameshift_variant 0.25 pyrazinamide Uncertain significance
rpsA 1834172 c.631_632insGG frameshift_variant 0.28 pyrazinamide Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834183 c.642T>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
rpsA 1834210 c.669C>T synonymous_variant 0.5 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834219 c.678C>G synonymous_variant 0.48 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.47 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.51 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834243 c.702G>C synonymous_variant 0.53 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.61 pyrazinamide
rpsA 1834255 c.714C>G synonymous_variant 0.61 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.59 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.57 pyrazinamide Not assoc w R - Interim
rpsA 1834298 p.Gln253Thr missense_variant 0.53 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.5 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834327 c.786G>C synonymous_variant 0.46 pyrazinamide
rpsA 1834340 p.Met267Leu missense_variant 0.44 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.44 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>C synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834384 c.843A>G synonymous_variant 0.42 pyrazinamide
rpsA 1834387 c.846C>T synonymous_variant 0.39 pyrazinamide
rpsA 1834396 c.855G>T synonymous_variant 0.33 pyrazinamide
rpsA 1834399 p.His286Gln missense_variant 0.33 pyrazinamide
rpsA 1834408 c.867C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.36 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCTC synonymous_variant 0.36 pyrazinamide
rpsA 1834456 c.915T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.35 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.4 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.39 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.36 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834570 c.1029C>T synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
rpsA 1834600 c.1059G>C synonymous_variant 0.42 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.5 pyrazinamide
rpsA 1834612 c.1071G>T synonymous_variant 0.48 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.5 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.5 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.55 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.55 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.38 pyrazinamide
rpsA 1834859 p.Ala440Thr missense_variant 1.0 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
ndh 2102193 p.Arg284Trp missense_variant 1.0 isoniazid Uncertain significance
delamanid Uncertain significance
ethionamide Uncertain significance
ndh 2103173 c.-132delG upstream_gene_variant 1.0 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
katG 2156025 c.87C>A synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2168011 p.Ser868Arg missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168319 p.Thr765Ile missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2168814 c.1798dupA frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
eis 2715125 p.Thr70Ala missense_variant 1.0 kanamycin Uncertain significance
amikacin Uncertain significance
Rv2477c 2782927 c.1116A>G synonymous_variant 1.0 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
amikacin Not assoc w R - Interim
Rv2681 2997325 p.Ala196Val missense_variant 1.0 capreomycin Uncertain significance
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3083 3448783 p.Val94Ile missense_variant 1.0 ethionamide Uncertain significance
lpqB 3623372 c.1539G>C synonymous_variant 1.0 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
lpqB 3623730 p.Ser394Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3624350 c.561G>T synonymous_variant 1.0 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
lpqB 3624486 p.Asp142Gly missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3624593 c.318G>A synonymous_variant 1.0 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
lpqB 3624710 c.201G>A synonymous_variant 0.95 rifampicin Not assoc w R
bedaquiline Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
rpoA 3877656 c.852T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877659 c.849G>T synonymous_variant 0.2 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.21 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877683 c.825G>C synonymous_variant 0.23 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.31 rifampicin
rpoA 3877731 c.777G>T synonymous_variant 0.32 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877746 c.762G>C synonymous_variant 0.3 rifampicin
rpoA 3877752 p.Asp252Glu missense_variant 0.29 rifampicin
rpoA 3877764 p.Ala248Ser missense_variant 0.3 rifampicin
rpoA 3877770 p.Ser246Ala missense_variant 0.31 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877842 c.666A>G synonymous_variant 0.53 rifampicin
rpoA 3877856 c.652T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877866 c.642G>C synonymous_variant 0.5 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>T synonymous_variant 0.5 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.46 rifampicin
rpoA 3877898 p.Pro204Ala missense_variant 0.49 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.5 rifampicin
rpoA 3877902 p.Ile202Met missense_variant 0.5 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877935 p.Lys191Arg missense_variant 0.5 rifampicin
rpoA 3877938 c.570C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>T synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.53 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoA 3877998 c.510G>C synonymous_variant 0.54 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoA 3878010 c.498C>G synonymous_variant 0.5 rifampicin
rpoA 3878013 c.495T>C synonymous_variant 0.5 rifampicin
rpoA 3878019 c.489A>G synonymous_variant 0.5 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.46 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.45 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.45 rifampicin
rpoA 3878034 c.474A>G synonymous_variant 0.45 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>G synonymous_variant 0.42 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.42 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.44 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.46 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.46 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.48 rifampicin
rpoA 3878082 c.426T>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3878102 p.Val136Ile missense_variant 0.5 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.5 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.52 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.51 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.48 rifampicin
rpoA 3878136 c.372C>T synonymous_variant 0.5 rifampicin
rpoA 3878141 p.GlyMet122AspLeu missense_variant 0.46 rifampicin
rpoA 3878161 c.345_346delCG frameshift_variant 0.48 rifampicin
rpoA 3878166 c.341_342insGT frameshift_variant 0.47 rifampicin
rpoA 3878172 c.336G>C synonymous_variant 0.45 rifampicin
rpoA 3878175 c.333G>T synonymous_variant 0.45 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.41 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.38 rifampicin Uncertain significance
rpoA 3878199 c.309T>C synonymous_variant 0.38 rifampicin
rpoA 3878205 c.303T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878217 p.Leu97Val missense_variant 0.44 rifampicin
rpoA 3878241 p.Glu89Asp missense_variant 0.35 rifampicin
rpoA 3878250 c.258C>G synonymous_variant 0.33 rifampicin
rpoA 3878253 c.255G>C synonymous_variant 0.31 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.33 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.33 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.38 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.36 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.36 rifampicin
rpoA 3878310 c.198G>C synonymous_variant 0.38 rifampicin
rpoA 3878322 c.186A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
clpC1 4038403 c.2302T>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
clpC1 4038740 c.1965G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038743 c.1962G>C synonymous_variant 0.32 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.34 pyrazinamide
clpC1 4038764 c.1941C>G synonymous_variant 0.34 pyrazinamide
clpC1 4038767 c.1938G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.36 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038794 p.Ser637Thr missense_variant 0.39 pyrazinamide
clpC1 4038808 c.1896_1897insC frameshift_variant 0.42 pyrazinamide
clpC1 4038811 c.1893delT frameshift_variant 0.38 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.52 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.53 pyrazinamide Not assoc w R - Interim
clpC1 4038896 c.1809C>G synonymous_variant 0.61 pyrazinamide
clpC1 4038905 c.1800A>G synonymous_variant 0.64 pyrazinamide
clpC1 4038911 c.1794G>T synonymous_variant 0.58 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.56 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.56 pyrazinamide
clpC1 4038926 c.1779G>C synonymous_variant 0.55 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.55 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.58 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.59 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.57 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.56 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4038986 p.Asp573Glu missense_variant 0.56 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.56 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039016 c.1689C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.53 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.46 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.4 pyrazinamide
clpC1 4039100 c.1605C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.4 pyrazinamide
clpC1 4039118 c.1587C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.23 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039181 c.1522_1524delTTGinsCTC synonymous_variant 0.21 pyrazinamide
clpC1 4039187 c.1518G>T synonymous_variant 0.19 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.21 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.25 pyrazinamide Uncertain significance
clpC1 4039574 p.Ala377Ser missense_variant 0.26 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039580 c.1125C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039589 p.Val372Ile missense_variant 0.27 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039642 p.Thr355Ala missense_variant 0.37 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039652 p.Thr351Ser missense_variant 0.35 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.35 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.27 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.28 pyrazinamide
clpC1 4039823 c.882T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.29 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039876 p.Asn277Asp missense_variant 0.33 pyrazinamide
clpC1 4039895 p.Lys270Arg missense_variant 0.31 pyrazinamide Uncertain significance
clpC1 4039898 c.807C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039925 c.780C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.26 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.31 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039982 c.723G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039994 p.Glu237Asn missense_variant 0.24 pyrazinamide
clpC1 4040002 p.His235Asn missense_variant 0.23 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.23 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
glpK 4138977 p.Gly260Ala missense_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Not assoc w R
ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242970 c.3108C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4246551 p.Asn13Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
aftB 4267858 p.Ile327Val missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269351 c.483C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R