TB-Profiler result

Run: SRR1173453
Summary

Run ID: SRR1173453

Sample name:

Date: 2024-10-04T04:03:19.049261

Number of reads: 1773864

Percentage reads mapped: 74.27

Median coverage: 39.0

Strain: lineage4.4.1.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.4.1 Euro-American (S-type) None 0.9
lineage4 Euro-American None 0.99
lineage4.4.1.1 Euro-American None 0.96
lineage4.4 Euro-American None 0.88
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
gid c.115delC Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.25 ethambutol Mutation from literature
gid 4408087 c.115delC frameshift_variant 0.91 streptomycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 522 c.522T>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 525 c.525T>C synonymous_variant 0.19 isoniazid
dnaA 534 c.534T>G synonymous_variant 0.18 isoniazid
dnaA 540 c.540C>G synonymous_variant 0.21 isoniazid
dnaA 543 c.543C>G synonymous_variant 0.21 isoniazid
dnaA 549 c.549C>T synonymous_variant 0.22 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.23 isoniazid
dnaA 576 c.576G>C synonymous_variant 0.23 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 591 c.591C>G synonymous_variant 0.2 isoniazid
dnaA 600 c.600T>C synonymous_variant 0.16 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.14 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.18 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.22 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 813 c.813C>T synonymous_variant 0.14 isoniazid
dnaA 1059 c.1059C>G synonymous_variant 0.16 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.22 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.24 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.24 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.25 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.27 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.28 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.25 isoniazid
dnaA 1164 c.1164A>T synonymous_variant 0.26 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.26 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.22 isoniazid
dnaA 1177 p.Ala393Ser missense_variant 0.21 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.18 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.17 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.19 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.17 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.15 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.22 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.22 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.21 isoniazid
dnaA 1293 c.1293T>G synonymous_variant 0.21 isoniazid
dnaA 1302 c.1302C>G synonymous_variant 0.18 isoniazid
dnaA 1314 c.1314A>G synonymous_variant 0.17 isoniazid
gyrB 6123 p.Ala295Gly missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6133 c.894G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6148 c.909C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6169 c.930C>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6209 c.970C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6253 c.1014G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6911 p.Asn558His missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7427 c.126G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7475 c.174A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7487 c.186C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7490 c.189C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7517 c.216G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7538 c.237G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7541 c.240C>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7883 c.582G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7892 c.591G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7919 p.Glu206Asp missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 7923 p.His208Tyr missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 8054 c.753T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8057 c.756A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8351 c.1050C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8462 c.1161A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8498 c.1197C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8537 c.1236G>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8556 p.Ala419Gln missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8562 c.1261C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9182 c.1881T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9204 p.Ser635Thr missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.28 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9275 c.1974G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9281 c.1980C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9311 c.2010C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
Rv0010c 13893 c.-335T>G upstream_gene_variant 0.15 isoniazid
Rv0010c 13903 c.-345A>G upstream_gene_variant 0.17 isoniazid
Rv0010c 13906 c.-348C>T upstream_gene_variant 0.17 isoniazid
Rv0010c 13909 c.-351G>C upstream_gene_variant 0.17 isoniazid
fgd1 490887 c.105G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 490902 c.120T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490905 c.123T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 490911 c.129T>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 490917 c.135C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490921 p.Gln47Glu missense_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 490932 c.150T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491106 c.324T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491121 c.339A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491137 p.Glu119Gln missense_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491232 c.450T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491241 p.Asp153Glu missense_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491502 c.720G>A synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491508 c.726A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 491509 c.727T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 491512 p.Asn244Glu missense_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 491526 c.744T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 491542 c.760T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fgd1 491547 c.765A>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491550 c.768T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
mshA 575713 c.366G>A synonymous_variant 0.32 isoniazid
ethionamide
mshA 575719 c.372C>T synonymous_variant 0.32 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.42 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.45 isoniazid
ethionamide
mshA 575746 c.399C>G synonymous_variant 0.5 isoniazid
ethionamide
mshA 575767 c.420G>A synonymous_variant 0.5 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.33 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.33 isoniazid
ethionamide
mshA 575827 c.480G>A synonymous_variant 0.33 isoniazid
ethionamide
ccsA 620241 c.351C>T synonymous_variant 0.72 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv0565c 657592 c.-122A>C upstream_gene_variant 0.21 ethionamide
Rv0565c 657596 c.-126G>C upstream_gene_variant 0.2 ethionamide
Rv0565c 657602 c.-132C>G upstream_gene_variant 0.21 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.28 ethionamide
Rv0565c 657639 c.-169C>G upstream_gene_variant 0.27 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.27 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.32 ethionamide
Rv0565c 657678 c.-209_-208delAAinsGG upstream_gene_variant 0.26 ethionamide
Rv0565c 657686 c.-216C>G upstream_gene_variant 0.23 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAG upstream_gene_variant 0.22 ethionamide
hadA 732295 c.366G>C synonymous_variant 0.28 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.27 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.27 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.29 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.29 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.34 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.38 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.37 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.18 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.16 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.17 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.17 isoniazid
nusG 734340 c.87T>G synonymous_variant 0.19 rifampicin
nusG 734349 c.96C>T synonymous_variant 0.26 rifampicin
nusG 734352 c.99T>C synonymous_variant 0.21 rifampicin
nusG 734370 c.117A>G synonymous_variant 0.21 rifampicin
nusG 734373 c.120G>C synonymous_variant 0.23 rifampicin
nusG 734376 c.123G>A synonymous_variant 0.25 rifampicin
nusG 734407 p.Val52Ile missense_variant 0.3 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.26 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.26 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.25 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.27 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.23 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.2 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.24 rifampicin
nusG 734511 c.258C>T synonymous_variant 0.22 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.21 rifampicin
nusG 734778 c.525G>C synonymous_variant 0.24 rifampicin
rpoB 760223 c.417T>C synonymous_variant 0.18 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.22 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.27 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.29 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.26 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.27 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.25 rifampicin Uncertain significance
rpoB 760418 c.612G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.31 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.29 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.26 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.24 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.31 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.2 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.21 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.23 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.23 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.23 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.2 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.18 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>A synonymous_variant 0.32 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.31 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.34 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.34 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.34 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761297 c.1491C>T synonymous_variant 0.27 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761510 c.1704T>C synonymous_variant 0.17 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.24 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.44 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.26 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.19 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.16 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.19 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>G synonymous_variant 0.26 rifampicin
rpoB 761882 c.2076C>G synonymous_variant 0.26 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.24 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.25 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.26 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.25 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.25 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.24 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.24 rifampicin
rpoB 761924 c.2118G>A synonymous_variant 0.29 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.28 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.31 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.28 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.24 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.28 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.26 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.25 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.34 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.32 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.19 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.19 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.21 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.16 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.2 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.18 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.17 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.17 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.18 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.2 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>T upstream_gene_variant 0.23 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762521 c.-849C>G upstream_gene_variant 0.22 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.21 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.21 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.21 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.18 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.27 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.21 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.19 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.18 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.21 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.23 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.35 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.35 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTTG synonymous_variant 0.18 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763765 c.396T>C synonymous_variant 0.15 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.15 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.16 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.23 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.17 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.18 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.18 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.17 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.18 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.18 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.19 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.19 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.22 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.24 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.23 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.21 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.23 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.36 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764110 c.741C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.36 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.35 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.27 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.29 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.3 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.23 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.23 rifampicin
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.23 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764503 c.1134G>C synonymous_variant 0.33 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.35 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTTG synonymous_variant 0.34 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.32 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.36 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.32 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.19 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.17 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.21 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.21 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.24 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.24 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765319 c.1950A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765325 c.1956C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.22 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.22 rifampicin Uncertain significance
rpoC 765349 c.1980T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.24 rifampicin Uncertain significance
rpoC 765493 c.2124G>C synonymous_variant 0.25 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.27 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.28 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.26 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.2 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.23 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.38 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.4 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.26 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.24 rifampicin
rpoC 766015 c.2646G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.26 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.23 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.21 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.34 rifampicin
rpoC 766444 c.3075C>G synonymous_variant 0.31 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.32 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.41 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766528 c.3159T>G synonymous_variant 0.41 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.5 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.42 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.41 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.44 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.44 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.42 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.41 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.4 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.38 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.35 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.45 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.47 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766769 c.3400C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.45 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.34 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.22 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.27 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.27 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775939 p.Ala848Ser missense_variant 0.15 bedaquiline
clofazimine
mmpL5 775946 c.2535C>G synonymous_variant 0.15 bedaquiline
clofazimine
mmpL5 775966 p.Ala839Ser missense_variant 0.16 bedaquiline
clofazimine
mmpL5 775975 c.2506T>C synonymous_variant 0.31 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.31 bedaquiline
clofazimine
mmpL5 775997 c.2484T>C synonymous_variant 0.24 bedaquiline
clofazimine
mmpL5 776000 c.2481G>C synonymous_variant 0.18 bedaquiline
clofazimine
mmpL5 776009 c.2472A>G synonymous_variant 0.26 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781608 p.Ser17Gly missense_variant 0.24 streptomycin
rpsL 781631 c.72G>C synonymous_variant 0.28 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.3 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.3 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.37 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.29 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.3 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.32 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.31 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.31 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.3 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.39 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.45 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.41 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.38 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.31 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.33 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.24 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.23 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.21 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.2 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.26 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.35 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.34 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.37 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.38 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.35 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.36 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.33 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.2 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.22 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.2 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.25 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.28 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.28 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.27 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.26 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.26 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.26 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.2 linezolid
rplC 800814 c.6A>G synonymous_variant 0.16 linezolid
rplC 800817 c.9A>T synonymous_variant 0.17 linezolid
rplC 800844 c.36T>C synonymous_variant 0.25 linezolid
rplC 800865 c.57A>G synonymous_variant 0.24 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.24 linezolid
rplC 800874 c.66A>G synonymous_variant 0.26 linezolid
rplC 800877 c.69A>C synonymous_variant 0.27 linezolid
rplC 800880 c.72A>G synonymous_variant 0.27 linezolid
rplC 800889 c.81C>G synonymous_variant 0.3 linezolid
rplC 800907 c.99C>G synonymous_variant 0.27 linezolid
rplC 800916 c.108A>G synonymous_variant 0.22 linezolid
rplC 801222 c.414T>C synonymous_variant 0.21 linezolid
rplC 801228 c.420T>C synonymous_variant 0.2 linezolid
rplC 801357 c.549T>C synonymous_variant 0.18 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.18 linezolid
rplC 801396 c.588T>C synonymous_variant 0.19 linezolid
rplC 801402 c.594T>C synonymous_variant 0.21 linezolid
rplC 801405 c.597T>C synonymous_variant 0.21 linezolid
rplC 801417 c.609T>C synonymous_variant 0.17 linezolid
rplC 801423 c.615G>C synonymous_variant 0.17 linezolid
fbiC 1303560 c.630G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.35 pretomanid
delamanid
clofazimine
fbiC 1303584 c.654C>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303590 c.660A>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303617 c.687C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303632 c.702T>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303638 c.708A>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303686 c.756C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1303701 c.771C>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303716 c.786C>T synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303732 p.Ser268Ala missense_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303749 c.819G>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.32 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303923 c.993C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303929 c.999G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303947 c.1017T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303948 p.Gly340Arg missense_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303969 p.Val347Ile missense_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303973 p.Gly348Ala missense_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303981 p.Val351Ile missense_variant 0.33 pretomanid
delamanid
clofazimine
fbiC 1303995 c.1065C>T synonymous_variant 0.36 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1304008 c.1078T>C synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304034 c.1104A>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304040 c.1110C>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304046 c.1116C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304049 c.1119T>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304058 c.1128G>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304059 c.1129C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304064 c.1134G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304067 c.1137G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304520 c.1590A>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304523 c.1593G>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304526 c.1596T>A synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304544 c.1614T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304545 p.Val539Thr missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiC 1304574 c.1644C>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1304748 c.1818T>C synonymous_variant 0.41 pretomanid
delamanid
clofazimine
fbiC 1304754 c.1824G>A synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>C synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304790 c.1860C>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.34 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>G synonymous_variant 0.3 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
sigE 1364424 c.12C>T synonymous_variant 0.94 pyrazinamide Not assoc w R - Interim
sigE 1364820 c.408A>G synonymous_variant 0.21 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.24 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.25 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.31 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.32 pyrazinamide
sigE 1364866 p.Ala152Ser missense_variant 0.31 pyrazinamide
sigE 1364887 c.475_477delTTAinsCTG synonymous_variant 0.29 pyrazinamide
atpE 1461185 c.141G>C synonymous_variant 0.15 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.16 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.25 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.22 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.22 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
inhA 1674280 p.Arg27Lys missense_variant 0.16 isoniazid
ethionamide
inhA 1674285 c.84A>G synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674301 c.102_103delCC frameshift_variant 0.19 isoniazid
ethionamide
inhA 1674307 c.106C>T synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674315 c.114C>G synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674321 c.120G>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674480 c.279T>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674486 c.285T>C synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674489 c.288G>C synonymous_variant 0.19 isoniazid
ethionamide
inhA 1674507 c.306G>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674537 c.336C>G synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.23 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.27 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.29 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.3 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.39 isoniazid
ethionamide
inhA 1674627 c.426T>G synonymous_variant 0.38 isoniazid
ethionamide
inhA 1674630 c.429C>G synonymous_variant 0.41 isoniazid
ethionamide
inhA 1674636 c.435C>G synonymous_variant 0.44 isoniazid
ethionamide
inhA 1674654 c.453G>C synonymous_variant 0.38 isoniazid
ethionamide
inhA 1674693 c.492C>G synonymous_variant 0.23 isoniazid
ethionamide
rpsA 1833589 c.48A>T synonymous_variant 0.2 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.23 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.22 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.21 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.25 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.27 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.32 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.23 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.25 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834201 c.660C>T synonymous_variant 0.28 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.27 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.23 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.23 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.24 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.23 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.29 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.31 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.34 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.24 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.26 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.26 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.31 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.32 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.3 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.25 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.26 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102990 p.Val18Ala missense_variant 0.95 isoniazid Not assoc w R
delamanid Uncertain significance
ethionamide Uncertain significance
PPE35 2169840 p.Gly258Asp missense_variant 0.96 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517947 c.-168C>T upstream_gene_variant 0.33 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.31 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.27 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.27 isoniazid
kasA 2518019 c.-96A>G upstream_gene_variant 0.21 isoniazid
kasA 2518025 c.-90G>C upstream_gene_variant 0.18 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.19 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.18 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.17 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.2 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.24 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.26 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.27 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.19 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.23 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.23 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.2 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.22 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.19 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.2 isoniazid
kasA 2518717 c.603C>T synonymous_variant 0.2 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.22 isoniazid
kasA 2518741 c.627G>C synonymous_variant 0.2 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.18 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.23 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.26 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.27 isoniazid
kasA 2518816 c.702C>A synonymous_variant 0.3 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.31 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.31 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.33 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.31 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.28 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.26 isoniazid
kasA 2518888 c.774C>T synonymous_variant 0.24 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.23 isoniazid
kasA 2519137 c.1023T>C synonymous_variant 0.22 isoniazid
kasA 2519146 c.1032C>A synonymous_variant 0.19 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.21 isoniazid
ahpC 2726354 c.162G>C synonymous_variant 0.22 isoniazid
ahpC 2726357 c.165A>G synonymous_variant 0.22 isoniazid Not assoc w R - Interim
ahpC 2726366 c.174G>C synonymous_variant 0.19 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.21 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.21 isoniazid Not assoc w R - Interim
Rv2477c 2782483 c.1560G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.21 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.24 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783041 c.1002C>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.26 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783116 c.927T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783320 c.723C>T synonymous_variant 0.16 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783332 c.711T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783365 c.678C>T synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783373 p.Glu224Gln missense_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.21 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783926 c.117C>T synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.34 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.33 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.26 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2784472 c.-430C>A upstream_gene_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
ribD 2987560 p.Ala241Asp missense_variant 0.94 para-aminosalicylic_acid
Rv2752c 3065947 p.Gly82Ala missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065955 c.235_237delTTGinsCTC synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066002 p.Met64Leu missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066024 c.168T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066054 c.138T>G synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066066 c.126T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066075 c.117A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066087 c.105A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3066707 c.-516A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066714 c.-523G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066744 c.-553C>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066747 c.-558_-556delCAAinsATC upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066756 c.-565G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066765 c.-574G>C upstream_gene_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066774 c.-583T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066807 c.-616T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066819 c.-628T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067355 c.591A>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067451 c.495G>A synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067463 p.Ile161Val missense_variant 0.29 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067470 p.Asn159Ser missense_variant 0.28 para-aminosalicylic_acid
thyX 3067682 c.264G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067826 c.120C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074010 c.462C>A synonymous_variant 0.2 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448608 c.105G>A synonymous_variant 0.95 ethionamide Not assoc w R - Interim
Rv3236c 3612665 p.Val151Ala missense_variant 0.88 pyrazinamide Not assoc w R
lpqB 3624107 c.804C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624119 c.792C>G synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624124 p.Leu263Val missense_variant 0.21 rifampicin
bedaquiline
lpqB 3624125 c.786A>G synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624166 p.Met249Leu missense_variant 0.18 rifampicin
bedaquiline
lpqB 3624172 p.Val247Ile missense_variant 0.18 rifampicin
bedaquiline
lpqB 3624173 c.738A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624188 c.723G>C synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624191 c.720C>G synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624194 c.717C>A synonymous_variant 0.16 rifampicin
bedaquiline
lpqB 3624200 c.711A>G synonymous_variant 0.15 rifampicin
bedaquiline
lpqB 3624209 c.702A>C synonymous_variant 0.15 rifampicin
bedaquiline
lpqB 3624749 c.162G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625279 c.-369C>G upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625285 c.-375G>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625291 c.-381A>G upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.26 rifampicin Uncertain significance
bedaquiline
mtrB 3625762 c.852A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.28 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625840 c.-930A>G upstream_gene_variant 0.35 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3625876 c.738G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625882 c.732G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625888 c.-978G>T upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625909 c.-999T>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626684 c.-71G>T upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626704 c.-91C>T upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626774 c.-163_-161delAGGinsCGC upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.15 rifampicin
bedaquiline
rpoA 3877542 c.966C>T synonymous_variant 0.19 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.21 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.26 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.17 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.31 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.33 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.34 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.28 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.28 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.22 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.23 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.24 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.24 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.24 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.24 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.21 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.21 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.25 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.18 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.17 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.17 rifampicin
rpoA 3878199 c.309T>C synonymous_variant 0.18 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.2 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878376 c.132G>C synonymous_variant 0.21 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.23 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.19 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.19 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.24 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.2 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.17 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.17 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.16 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.16 rifampicin
rpoA 3878826 c.-319A>T upstream_gene_variant 0.17 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.17 rifampicin
rpoA 3879040 c.-533G>C upstream_gene_variant 0.18 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.22 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.21 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.17 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.18 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.17 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.15 rifampicin
clpC1 4038212 c.2493T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.24 pyrazinamide
clpC1 4038272 p.Gly811Ser missense_variant 0.24 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038653 c.2052C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.16 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.16 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.24 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039484 c.1221T>G synonymous_variant 0.24 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.21 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.22 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.15 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.25 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040092 p.Ser205Thr missense_variant 0.15 pyrazinamide
clpC1 4040105 c.600C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040264 c.441C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040267 c.438A>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.41 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.35 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.36 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.29 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
panD 4044138 c.144T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
panD 4044150 c.132A>G synonymous_variant 0.24 pyrazinamide
panD 4044188 c.94T>C synonymous_variant 0.23 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.2 pyrazinamide
panD 4044213 c.69C>G synonymous_variant 0.22 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.23 pyrazinamide
panD 4045025 c.-744C>G upstream_gene_variant 0.22 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.25 pyrazinamide
panD 4045034 c.-753A>T upstream_gene_variant 0.23 pyrazinamide
glpK 4138568 c.1188A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138571 c.1185C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138579 c.1177C>T synonymous_variant 0.8 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
glpK 4138583 c.1173G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138586 c.1170C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138606 c.1150T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138631 c.1125C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138634 c.1122G>T synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138643 c.1113A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138664 c.1092G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138667 c.1089G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138670 c.1086G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138679 p.Met359Ile missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin
rifampicin Uncertain significance
ethambutol
glpK 4139630 c.126C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139651 p.His35Gln missense_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139675 c.81C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4238963 c.-900C>T upstream_gene_variant 0.82 ethambutol Not assoc w R
embC 4240033 c.171G>C synonymous_variant 0.16 ethambutol
embC 4240036 c.174A>G synonymous_variant 0.16 ethambutol
embC 4240037 c.175T>C synonymous_variant 0.17 ethambutol
embC 4240059 p.Thr66Ser missense_variant 0.18 ethambutol
embC 4240065 p.Ala68Gly missense_variant 0.17 ethambutol
embC 4240069 c.207T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4240072 c.210C>G synonymous_variant 0.16 ethambutol
embC 4240087 c.225T>C synonymous_variant 0.16 ethambutol
embC 4240090 c.228C>T synonymous_variant 0.16 ethambutol
embC 4240632 p.Met257Thr missense_variant 0.29 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.29 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.28 ethambutol
embC 4240654 c.792C>T synonymous_variant 0.31 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.36 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.4 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.33 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.29 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.29 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.25 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.25 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.25 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.21 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.19 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.2 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.17 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.15 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.16 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.18 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.18 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.43 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.44 ethambutol
embC 4241137 c.1275G>C synonymous_variant 0.44 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.4 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.42 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 0.33 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.3 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.23 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245089 c.1857G>C synonymous_variant 0.15 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.17 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.19 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.27 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.27 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.24 ethambutol
embA 4245194 c.1962G>C synonymous_variant 0.19 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.17 ethambutol
embB 4245807 c.-707_-705delTTAinsCTG upstream_gene_variant 0.26 ethambutol
embA 4245820 p.Ser863Thr missense_variant 0.33 ethambutol
embB 4245830 c.-684G>C upstream_gene_variant 0.43 ethambutol
embB 4245845 c.-669T>G upstream_gene_variant 0.44 ethambutol
embB 4245848 c.-666C>G upstream_gene_variant 0.47 ethambutol
embB 4245860 c.-654C>G upstream_gene_variant 0.54 ethambutol
embB 4246355 c.-159G>C upstream_gene_variant 0.22 ethambutol
embA 4246359 p.Ala1043Pro missense_variant 0.22 ethambutol
embB 4246364 c.-150G>C upstream_gene_variant 0.22 ethambutol
embB 4246367 c.-147C>T upstream_gene_variant 0.21 ethambutol
embB 4246373 c.-141T>C upstream_gene_variant 0.22 ethambutol
embB 4246376 c.-138G>C upstream_gene_variant 0.25 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.28 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.29 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.32 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.21 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.27 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.27 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.23 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.21 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.26 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.28 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.31 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.32 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.3 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.31 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.31 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4248206 p.Ser565Gly missense_variant 0.43 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.36 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.36 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.27 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.26 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.16 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.16 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.18 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.18 ethambutol
embB 4248322 c.1809G>C synonymous_variant 0.19 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.18 ethambutol
aftB 4268384 p.Leu151Phe missense_variant 0.96 ethambutol Uncertain significance
aftB 4269201 c.-365A>G upstream_gene_variant 0.19 ethambutol
ubiA 4269271 p.Val188Ala missense_variant 0.17 ethambutol Uncertain significance
ubiA 4269841 c.-8G>A upstream_gene_variant 1.0 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin