TB-Profiler

Lineage	Family	RDs	Frequency
La1.2.BCG	M.bovis	None	0.07
lineage1	Indo-Oceanic	RD239	0.89
lineage1.2.1.2.1	Indo-Oceanic	RD239	0.99
lineage1.2.1	Indo-Oceanic	RD239	0.92

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
fgd1	490984	c.202_204delCTGinsAC	frameshift_variant&missense_variant	0.28	pretomanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
delamanid	Assoc w R - Interim	Confers DLM-PMD cross-resistance
rrs	1472307	n.462C>T	non_coding_transcript_exon_variant	0.56	streptomycin	Uncertain significance	Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	30	c.30C>G	synonymous_variant	0.55	isoniazid
dnaA	424	p.Asp142Asn	missense_variant	1.0	isoniazid	Uncertain significance
dnaA	939	c.939C>A	synonymous_variant	0.76	isoniazid	Not assoc w R - Interim
dnaA	942	c.942C>G	synonymous_variant	0.24	isoniazid
dnaA	945	c.945G>A	synonymous_variant	0.24	isoniazid
dnaA	955	c.955A>C	synonymous_variant	0.25	isoniazid
dnaA	984	c.984T>C	synonymous_variant	0.23	isoniazid	Not assoc w R - Interim
dnaA	993	c.993A>G	synonymous_variant	0.2	isoniazid
dnaA	996	c.996A>G	synonymous_variant	0.21	isoniazid
dnaA	999	c.999C>G	synonymous_variant	0.21	isoniazid
dnaA	1003	c.1003C>T	synonymous_variant	0.21	isoniazid
dnaA	1008	c.1008G>A	synonymous_variant	0.22	isoniazid	Not assoc w R - Interim
dnaA	1014	c.1014C>G	synonymous_variant	0.23	isoniazid
dnaA	1024	c.1024T>C	synonymous_variant	0.27	isoniazid
dnaA	1038	c.1038A>T	synonymous_variant	0.3	isoniazid
dnaA	1041	c.1041G>A	synonymous_variant	0.27	isoniazid
dnaA	1047	c.1047A>G	synonymous_variant	0.27	isoniazid
dnaA	1068	c.1068T>C	synonymous_variant	0.32	isoniazid
dnaA	1092	c.1092T>C	synonymous_variant	0.35	isoniazid	Not assoc w R - Interim
dnaA	1098	c.1098A>G	synonymous_variant	0.45	isoniazid
dnaA	1104	c.1104T>C	synonymous_variant	0.48	isoniazid
dnaA	1110	c.1110T>C	synonymous_variant	0.5	isoniazid
dnaA	1113	c.1113A>G	synonymous_variant	0.41	isoniazid
dnaA	1125	c.1125G>C	synonymous_variant	0.4	isoniazid
dnaA	1137	c.1137C>G	synonymous_variant	0.38	isoniazid
dnaA	1143	c.1143G>C	synonymous_variant	0.38	isoniazid
dnaA	1152	c.1152A>G	synonymous_variant	0.38	isoniazid
dnaA	1153	c.1153T>C	synonymous_variant	0.38	isoniazid
dnaA	1188	c.1188G>A	synonymous_variant	0.32	isoniazid
dnaA	1191	c.1191T>C	synonymous_variant	0.32	isoniazid
dnaA	1197	c.1197T>C	synonymous_variant	0.34	isoniazid	Not assoc w R - Interim
dnaA	1204	c.1204C>T	synonymous_variant	0.35	isoniazid
dnaA	1218	c.1218C>G	synonymous_variant	0.35	isoniazid
dnaA	1220	p.Asn407Ser	missense_variant	0.35	isoniazid
dnaA	1230	c.1230A>G	synonymous_variant	0.5	isoniazid
dnaA	1236	c.1236C>T	synonymous_variant	0.48	isoniazid
dnaA	1242	c.1242G>C	synonymous_variant	0.52	isoniazid
dnaA	1245	c.1245G>C	synonymous_variant	0.52	isoniazid	Not assoc w R - Interim
dnaA	1254	c.1254T>C	synonymous_variant	0.48	isoniazid
dnaA	1278	c.1278T>C	synonymous_variant	0.5	isoniazid
dnaA	1284	c.1284C>G	synonymous_variant	0.48	isoniazid
dnaA	1287	c.1287A>G	synonymous_variant	0.44	isoniazid
dnaA	1290	c.1290G>A	synonymous_variant	0.44	isoniazid
dnaA	1293	c.1293T>C	synonymous_variant	0.44	isoniazid
dnaA	1299	c.1299G>C	synonymous_variant	0.4	isoniazid	Not assoc w R - Interim
dnaA	1302	c.1302C>A	synonymous_variant	0.6	isoniazid	Not assoc w R
dnaA	1311	c.1311C>G	synonymous_variant	0.38	isoniazid
dnaA	1314	c.1314A>G	synonymous_variant	0.38	isoniazid
dnaA	1317	c.1317A>G	synonymous_variant	0.33	isoniazid
dnaA	1320	c.1320G>C	synonymous_variant	0.33	isoniazid
dnaA	1323	c.1323C>T	synonymous_variant	0.33	isoniazid	Not assoc w R - Interim
dnaA	1332	c.1332A>C	synonymous_variant	0.4	isoniazid	Not assoc w R - Interim
dnaA	1338	c.1338T>C	synonymous_variant	0.4	isoniazid
dnaA	1353	c.1353T>C	synonymous_variant	0.44	isoniazid
dnaA	1371	c.1371T>G	synonymous_variant	0.54	isoniazid
dnaA	1375	c.1375T>C	synonymous_variant	0.54	isoniazid
dnaA	1395	c.1395G>C	synonymous_variant	0.57	isoniazid
dnaA	1404	c.1404T>C	synonymous_variant	0.57	isoniazid
dnaA	1407	c.1407T>C	synonymous_variant	0.57	isoniazid
dnaA	1413	c.1413A>C	synonymous_variant	0.57	isoniazid
dnaA	1416	c.1416C>G	synonymous_variant	0.5	isoniazid
dnaA	1428	c.1428C>G	synonymous_variant	0.62	isoniazid
dnaA	1449	c.1449G>A	synonymous_variant	0.47	isoniazid
dnaA	1461	c.1461C>G	synonymous_variant	0.32	isoniazid
dnaA	1470	c.1470C>T	synonymous_variant	0.32	isoniazid
gyrB	6112	p.Met291Ile	missense_variant	1.0	levofloxacin	Not assoc w R
gyrB	6112	p.Met291Ile	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	6742	c.-560A>G	upstream_gene_variant	0.3	levofloxacin
gyrA	6742	c.-560A>G	upstream_gene_variant	0.3	moxifloxacin
gyrB	6745	c.1506T>G	synonymous_variant	0.29	levofloxacin	Not assoc w R - Interim
gyrB	6745	c.1506T>G	synonymous_variant	0.29	moxifloxacin	Not assoc w R - Interim
gyrA	6751	c.-551G>C	upstream_gene_variant	0.29	levofloxacin
gyrA	6751	c.-551G>C	upstream_gene_variant	0.29	moxifloxacin
gyrA	7427	c.126G>C	synonymous_variant	0.27	levofloxacin
gyrA	7427	c.126G>C	synonymous_variant	0.27	moxifloxacin
gyrA	7442	c.141G>C	synonymous_variant	0.27	levofloxacin
gyrA	7442	c.141G>C	synonymous_variant	0.27	moxifloxacin
gyrA	7451	c.150C>G	synonymous_variant	0.27	levofloxacin
gyrA	7451	c.150C>G	synonymous_variant	0.27	moxifloxacin
gyrA	7457	c.156T>C	synonymous_variant	0.32	levofloxacin
gyrA	7457	c.156T>C	synonymous_variant	0.32	moxifloxacin
gyrA	7475	c.174A>G	synonymous_variant	0.42	levofloxacin	Not assoc w R - Interim
gyrA	7475	c.174A>G	synonymous_variant	0.42	moxifloxacin	Not assoc w R - Interim
gyrA	7480	p.Phe60Tyr	missense_variant	0.39	levofloxacin
gyrA	7480	p.Phe60Tyr	missense_variant	0.39	moxifloxacin
gyrA	7484	c.183T>C	synonymous_variant	0.39	levofloxacin
gyrA	7484	c.183T>C	synonymous_variant	0.39	moxifloxacin
gyrA	7514	c.213C>G	synonymous_variant	0.43	levofloxacin
gyrA	7514	c.213C>G	synonymous_variant	0.43	moxifloxacin
gyrA	7523	c.222C>A	synonymous_variant	0.55	levofloxacin
gyrA	7523	c.222C>A	synonymous_variant	0.55	moxifloxacin
gyrA	7532	c.231T>C	synonymous_variant	0.55	levofloxacin	Not assoc w R - Interim
gyrA	7532	c.231T>C	synonymous_variant	0.55	moxifloxacin	Not assoc w R - Interim
gyrA	7541	c.240C>G	synonymous_variant	0.57	levofloxacin	Not assoc w R - Interim
gyrA	7541	c.240C>G	synonymous_variant	0.57	moxifloxacin	Not assoc w R - Interim
gyrA	7547	c.246C>T	synonymous_variant	0.57	levofloxacin	Not assoc w R - Interim
gyrA	7547	c.246C>T	synonymous_variant	0.57	moxifloxacin	Not assoc w R - Interim
gyrA	7585	p.Ser95Thr	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7595	c.294C>G	synonymous_variant	0.67	levofloxacin
gyrA	7595	c.294C>G	synonymous_variant	0.67	moxifloxacin
gyrA	7601	c.300C>G	synonymous_variant	0.62	levofloxacin	Not assoc w R - Interim
gyrA	7601	c.300C>G	synonymous_variant	0.62	moxifloxacin	Not assoc w R - Interim
gyrA	7607	c.306C>G	synonymous_variant	0.62	levofloxacin	Not assoc w R - Interim
gyrA	7607	c.306C>G	synonymous_variant	0.62	moxifloxacin	Not assoc w R - Interim
gyrA	7622	c.321C>T	synonymous_variant	0.64	levofloxacin
gyrA	7622	c.321C>T	synonymous_variant	0.64	moxifloxacin
gyrA	7625	c.324G>C	synonymous_variant	0.69	levofloxacin
gyrA	7625	c.324G>C	synonymous_variant	0.69	moxifloxacin
gyrA	7631	c.330G>C	synonymous_variant	0.69	levofloxacin
gyrA	7631	c.330G>C	synonymous_variant	0.69	moxifloxacin
gyrA	7637	c.336C>G	synonymous_variant	0.69	levofloxacin
gyrA	7637	c.336C>G	synonymous_variant	0.69	moxifloxacin
gyrA	7658	c.357A>G	synonymous_variant	0.71	levofloxacin
gyrA	7658	c.357A>G	synonymous_variant	0.71	moxifloxacin
gyrA	7664	c.363T>C	synonymous_variant	0.82	levofloxacin
gyrA	7664	c.363T>C	synonymous_variant	0.82	moxifloxacin
gyrA	7670	c.369A>G	synonymous_variant	0.69	levofloxacin
gyrA	7670	c.369A>G	synonymous_variant	0.69	moxifloxacin
gyrA	7676	c.375G>C	synonymous_variant	0.69	levofloxacin
gyrA	7676	c.375G>C	synonymous_variant	0.69	moxifloxacin
gyrA	7683	c.382_384delAGGinsCC	frameshift_variant&missense_variant	0.6	levofloxacin
gyrA	7683	c.382_384delAGGinsCC	frameshift_variant&missense_variant	0.6	moxifloxacin
gyrA	7694	c.393A>G	synonymous_variant	0.6	levofloxacin
gyrA	7694	c.393A>G	synonymous_variant	0.6	moxifloxacin
gyrA	7697	c.396C>A	synonymous_variant	0.6	levofloxacin
gyrA	7697	c.396C>A	synonymous_variant	0.6	moxifloxacin
gyrA	7710	c.409_411delTTGinsCC	frameshift_variant&missense_variant	0.53	levofloxacin
gyrA	7710	c.409_411delTTGinsCC	frameshift_variant&missense_variant	0.53	moxifloxacin
gyrA	7715	c.414G>C	synonymous_variant	0.5	levofloxacin
gyrA	7715	c.414G>C	synonymous_variant	0.5	moxifloxacin
gyrA	7721	c.420G>A	synonymous_variant	0.5	levofloxacin	Not assoc w R - Interim
gyrA	7721	c.420G>A	synonymous_variant	0.5	moxifloxacin	Not assoc w R - Interim
gyrA	7725	c.424C>T	synonymous_variant	0.5	levofloxacin	Not assoc w R - Interim
gyrA	7725	c.424C>T	synonymous_variant	0.5	moxifloxacin
gyrA	7728	c.427_429delAGGinsCT	frameshift_variant&missense_variant	0.5	levofloxacin
gyrA	7728	c.427_429delAGGinsCT	frameshift_variant&missense_variant	0.5	moxifloxacin
gyrA	8135	c.834C>G	synonymous_variant	0.43	levofloxacin
gyrA	8135	c.834C>G	synonymous_variant	0.43	moxifloxacin
gyrA	8156	c.855T>C	synonymous_variant	0.43	levofloxacin
gyrA	8156	c.855T>C	synonymous_variant	0.43	moxifloxacin
gyrA	8168	c.867A>G	synonymous_variant	0.5	levofloxacin
gyrA	8168	c.867A>G	synonymous_variant	0.5	moxifloxacin
gyrA	8177	c.876A>C	synonymous_variant	0.57	levofloxacin
gyrA	8177	c.876A>C	synonymous_variant	0.57	moxifloxacin
gyrA	8189	c.888G>C	synonymous_variant	0.57	levofloxacin	Not assoc w R - Interim
gyrA	8189	c.888G>C	synonymous_variant	0.57	moxifloxacin	Not assoc w R - Interim
gyrA	8198	c.897T>C	synonymous_variant	0.6	levofloxacin	Not assoc w R - Interim
gyrA	8198	c.897T>C	synonymous_variant	0.6	moxifloxacin	Not assoc w R - Interim
gyrA	8207	c.906T>C	synonymous_variant	0.69	levofloxacin
gyrA	8207	c.906T>C	synonymous_variant	0.69	moxifloxacin
gyrA	8219	c.918T>C	synonymous_variant	0.75	levofloxacin	Not assoc w R - Interim
gyrA	8219	c.918T>C	synonymous_variant	0.75	moxifloxacin	Not assoc w R - Interim
gyrA	8225	c.924T>C	synonymous_variant	0.82	levofloxacin
gyrA	8225	c.924T>C	synonymous_variant	0.82	moxifloxacin
gyrA	8234	c.933T>C	synonymous_variant	0.82	levofloxacin
gyrA	8234	c.933T>C	synonymous_variant	0.82	moxifloxacin
gyrA	8237	c.936A>G	synonymous_variant	0.82	levofloxacin
gyrA	8237	c.936A>G	synonymous_variant	0.82	moxifloxacin
gyrA	8247	c.946_948delATCinsGG	frameshift_variant&missense_variant	0.82	levofloxacin
gyrA	8247	c.946_948delATCinsGG	frameshift_variant&missense_variant	0.82	moxifloxacin
gyrA	8264	c.963T>C	synonymous_variant	0.58	levofloxacin
gyrA	8264	c.963T>C	synonymous_variant	0.58	moxifloxacin
gyrA	8267	c.966G>C	synonymous_variant	0.58	levofloxacin	Not assoc w R - Interim
gyrA	8267	c.966G>C	synonymous_variant	0.58	moxifloxacin	Not assoc w R - Interim
gyrA	8270	c.969G>C	synonymous_variant	0.5	levofloxacin
gyrA	8270	c.969G>C	synonymous_variant	0.5	moxifloxacin
gyrA	8276	c.975G>A	synonymous_variant	0.5	levofloxacin
gyrA	8276	c.975G>A	synonymous_variant	0.5	moxifloxacin
gyrA	8283	c.982_984delATCinsCG	frameshift_variant&missense_variant	0.47	levofloxacin
gyrA	8283	c.982_984delATCinsCG	frameshift_variant&missense_variant	0.47	moxifloxacin
gyrA	8288	c.987T>C	synonymous_variant	0.54	levofloxacin	Not assoc w R - Interim
gyrA	8288	c.987T>C	synonymous_variant	0.54	moxifloxacin	Not assoc w R - Interim
gyrA	8294	c.993T>C	synonymous_variant	0.54	levofloxacin	Not assoc w R - Interim
gyrA	8294	c.993T>C	synonymous_variant	0.54	moxifloxacin	Not assoc w R - Interim
gyrA	8452	p.Ala384Val	missense_variant	0.72	levofloxacin	Not assoc w R
gyrA	8452	p.Ala384Val	missense_variant	0.72	moxifloxacin	Not assoc w R
gyrA	8603	c.1302A>G	synonymous_variant	0.33	levofloxacin	Not assoc w R - Interim
gyrA	8603	c.1302A>G	synonymous_variant	0.33	moxifloxacin	Not assoc w R - Interim
gyrA	8619	c.1318T>C	synonymous_variant	0.54	levofloxacin	Not assoc w R - Interim
gyrA	8619	c.1318T>C	synonymous_variant	0.54	moxifloxacin	Not assoc w R - Interim
gyrA	8636	c.1335A>C	synonymous_variant	0.44	levofloxacin	Not assoc w R - Interim
gyrA	8636	c.1335A>C	synonymous_variant	0.44	moxifloxacin	Not assoc w R - Interim
gyrA	8642	c.1341A>G	synonymous_variant	0.44	levofloxacin
gyrA	8642	c.1341A>G	synonymous_variant	0.44	moxifloxacin
gyrA	8672	c.1371A>G	synonymous_variant	0.41	levofloxacin	Not assoc w R - Interim
gyrA	8672	c.1371A>G	synonymous_variant	0.41	moxifloxacin	Not assoc w R - Interim
gyrA	8678	c.1377G>A	synonymous_variant	0.41	levofloxacin
gyrA	8678	c.1377G>A	synonymous_variant	0.41	moxifloxacin
gyrA	8693	c.1392T>C	synonymous_variant	0.44	levofloxacin
gyrA	8693	c.1392T>C	synonymous_variant	0.44	moxifloxacin
gyrA	8696	c.1395G>C	synonymous_variant	0.44	levofloxacin
gyrA	8696	c.1395G>C	synonymous_variant	0.44	moxifloxacin
gyrA	8699	c.1398A>G	synonymous_variant	0.44	levofloxacin
gyrA	8699	c.1398A>G	synonymous_variant	0.44	moxifloxacin
gyrA	8708	c.1407G>C	synonymous_variant	0.41	levofloxacin
gyrA	8708	c.1407G>C	synonymous_variant	0.41	moxifloxacin
gyrA	8711	c.1410A>C	synonymous_variant	0.41	levofloxacin
gyrA	8711	c.1410A>C	synonymous_variant	0.41	moxifloxacin
gyrA	8714	c.1413A>G	synonymous_variant	0.41	levofloxacin
gyrA	8714	c.1413A>G	synonymous_variant	0.41	moxifloxacin
gyrA	8729	c.1428T>C	synonymous_variant	0.35	levofloxacin
gyrA	8729	c.1428T>C	synonymous_variant	0.35	moxifloxacin
gyrA	8731	p.Gly477Ala	missense_variant	0.35	levofloxacin
gyrA	8731	p.Gly477Ala	missense_variant	0.35	moxifloxacin
gyrA	8740	p.Arg480His	missense_variant	0.42	levofloxacin
gyrA	8740	p.Arg480His	missense_variant	0.42	moxifloxacin
gyrA	8751	p.Ala484Ser	missense_variant	0.42	levofloxacin
gyrA	8751	p.Ala484Ser	missense_variant	0.42	moxifloxacin
gyrA	8762	c.1461G>C	synonymous_variant	0.4	levofloxacin	Not assoc w R - Interim
gyrA	8762	c.1461G>C	synonymous_variant	0.4	moxifloxacin	Not assoc w R - Interim
gyrA	8767	p.Arg489Lys	missense_variant	0.42	levofloxacin	Uncertain significance
gyrA	8767	p.Arg489Lys	missense_variant	0.42	moxifloxacin	Uncertain significance
gyrA	8801	c.1500G>C	synonymous_variant	0.4	levofloxacin
gyrA	8801	c.1500G>C	synonymous_variant	0.4	moxifloxacin
gyrA	8807	c.1506C>T	synonymous_variant	0.41	levofloxacin
gyrA	8807	c.1506C>T	synonymous_variant	0.41	moxifloxacin
gyrA	8810	c.1509A>G	synonymous_variant	0.41	levofloxacin
gyrA	8810	c.1509A>G	synonymous_variant	0.41	moxifloxacin
gyrA	8816	c.1515C>G	synonymous_variant	0.41	levofloxacin
gyrA	8816	c.1515C>G	synonymous_variant	0.41	moxifloxacin
gyrA	8818	p.Ser506Asn	missense_variant	0.41	levofloxacin	Uncertain significance
gyrA	8818	p.Ser506Asn	missense_variant	0.41	moxifloxacin	Uncertain significance
gyrA	8828	c.1527T>C	synonymous_variant	0.41	levofloxacin
gyrA	8828	c.1527T>C	synonymous_variant	0.41	moxifloxacin
gyrA	8829	c.1528T>C	synonymous_variant	0.41	levofloxacin	Not assoc w R - Interim
gyrA	8829	c.1528T>C	synonymous_variant	0.41	moxifloxacin	Not assoc w R - Interim
gyrA	8852	c.1551T>C	synonymous_variant	0.5	levofloxacin
gyrA	8852	c.1551T>C	synonymous_variant	0.5	moxifloxacin
gyrA	8867	c.1566A>G	synonymous_variant	0.5	levofloxacin	Not assoc w R - Interim
gyrA	8867	c.1566A>G	synonymous_variant	0.5	moxifloxacin	Not assoc w R - Interim
gyrA	8870	c.1569G>C	synonymous_variant	0.45	levofloxacin	Not assoc w R - Interim
gyrA	8870	c.1569G>C	synonymous_variant	0.45	moxifloxacin	Not assoc w R - Interim
gyrA	8873	c.1572A>C	synonymous_variant	0.45	levofloxacin	Not assoc w R - Interim
gyrA	8873	c.1572A>C	synonymous_variant	0.45	moxifloxacin	Not assoc w R - Interim
gyrA	8891	c.1590G>A	synonymous_variant	0.48	levofloxacin
gyrA	8891	c.1590G>A	synonymous_variant	0.48	moxifloxacin
gyrA	8897	c.1596T>C	synonymous_variant	0.5	levofloxacin	Not assoc w R - Interim
gyrA	8897	c.1596T>C	synonymous_variant	0.5	moxifloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	0.5	levofloxacin	Not assoc w R - Interim
gyrA	8903	c.1602T>C	synonymous_variant	0.5	moxifloxacin	Not assoc w R - Interim
gyrA	8933	c.1632G>C	synonymous_variant	0.55	levofloxacin
gyrA	8933	c.1632G>C	synonymous_variant	0.55	moxifloxacin
gyrA	8946	c.1645_1647delTTGinsCC	frameshift_variant&missense_variant	0.52	levofloxacin
gyrA	8946	c.1645_1647delTTGinsCC	frameshift_variant&missense_variant	0.52	moxifloxacin
gyrA	8987	c.1686C>A	synonymous_variant	0.5	levofloxacin
gyrA	8987	c.1686C>A	synonymous_variant	0.5	moxifloxacin
gyrA	8990	c.1689C>G	synonymous_variant	0.5	levofloxacin
gyrA	8990	c.1689C>G	synonymous_variant	0.5	moxifloxacin
gyrA	8996	c.1695T>C	synonymous_variant	0.47	levofloxacin
gyrA	8996	c.1695T>C	synonymous_variant	0.47	moxifloxacin
gyrA	8998	p.Leu566Trp	missense_variant	0.47	levofloxacin	Uncertain significance
gyrA	8998	p.Leu566Trp	missense_variant	0.47	moxifloxacin	Uncertain significance
gyrA	9050	p.Asp583Glu	missense_variant	0.37	levofloxacin	Uncertain significance
gyrA	9050	p.Asp583Glu	missense_variant	0.37	moxifloxacin	Uncertain significance
gyrA	9051	c.1750T>C	synonymous_variant	0.4	levofloxacin
gyrA	9051	c.1750T>C	synonymous_variant	0.4	moxifloxacin
gyrA	9056	c.1755C>G	synonymous_variant	0.46	levofloxacin	Not assoc w R - Interim
gyrA	9056	c.1755C>G	synonymous_variant	0.46	moxifloxacin	Not assoc w R - Interim
gyrA	9062	c.1761C>G	synonymous_variant	0.46	levofloxacin
gyrA	9062	c.1761C>G	synonymous_variant	0.46	moxifloxacin
gyrA	9065	c.1764C>G	synonymous_variant	0.4	levofloxacin
gyrA	9065	c.1764C>G	synonymous_variant	0.4	moxifloxacin
gyrA	9068	c.1767G>C	synonymous_variant	0.4	levofloxacin
gyrA	9068	c.1767G>C	synonymous_variant	0.4	moxifloxacin
gyrA	9071	c.1770G>C	synonymous_variant	0.4	levofloxacin
gyrA	9071	c.1770G>C	synonymous_variant	0.4	moxifloxacin
gyrA	9080	c.1779G>T	synonymous_variant	0.4	levofloxacin
gyrA	9080	c.1779G>T	synonymous_variant	0.4	moxifloxacin
gyrA	9089	c.1788G>C	synonymous_variant	0.4	levofloxacin
gyrA	9089	c.1788G>C	synonymous_variant	0.4	moxifloxacin
gyrA	9143	c.1842T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R
gyrA	9200	c.1899A>G	synonymous_variant	0.33	levofloxacin	Not assoc w R - Interim
gyrA	9200	c.1899A>G	synonymous_variant	0.33	moxifloxacin	Not assoc w R - Interim
gyrA	9204	p.Ser635Thr	missense_variant	0.35	levofloxacin
gyrA	9204	p.Ser635Thr	missense_variant	0.35	moxifloxacin
gyrA	9218	c.1917C>T	synonymous_variant	0.35	levofloxacin	Not assoc w R - Interim
gyrA	9218	c.1917C>T	synonymous_variant	0.35	moxifloxacin	Not assoc w R - Interim
gyrA	9227	c.1926C>G	synonymous_variant	0.32	levofloxacin	Not assoc w R - Interim
gyrA	9227	c.1926C>G	synonymous_variant	0.32	moxifloxacin	Not assoc w R - Interim
gyrA	9230	c.1929T>C	synonymous_variant	0.32	levofloxacin
gyrA	9230	c.1929T>C	synonymous_variant	0.32	moxifloxacin
gyrA	9233	c.1932C>G	synonymous_variant	0.35	levofloxacin
gyrA	9233	c.1932C>G	synonymous_variant	0.35	moxifloxacin
gyrA	9260	c.1959G>C	synonymous_variant	0.7	levofloxacin	Not assoc w R
gyrA	9260	c.1959G>C	synonymous_variant	0.7	moxifloxacin	Not assoc w R
gyrA	9267	p.Asn656Gly	missense_variant	0.32	levofloxacin
gyrA	9267	p.Asn656Gly	missense_variant	0.32	moxifloxacin
gyrA	9304	p.Gly668Asp	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	9304	p.Gly668Asp	missense_variant	1.0	moxifloxacin	Not assoc w R
Rv0010c	13175	c.384T>C	synonymous_variant	1.0	isoniazid	Not assoc w R
Rv0010c	13298	p.Ile87Met	missense_variant	1.0	isoniazid	Not assoc w R
Rv0010c	13460	c.99T>C	synonymous_variant	1.0	isoniazid	Not assoc w R
fgd1	490962	c.180T>G	synonymous_variant	0.28	clofazimine
					pretomanid
					delamanid
fgd1	490974	c.192T>C	synonymous_variant	0.28	clofazimine
					pretomanid
					delamanid
fgd1	490977	c.195C>G	synonymous_variant	0.28	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid
fgd1	490980	p.Asn66Lys	missense_variant	0.28	clofazimine
					pretomanid
					delamanid
fgd1	490987	p.Leu69Thr	missense_variant	0.28	clofazimine
					pretomanid
					delamanid
fgd1	490998	c.216T>C	synonymous_variant	0.31	clofazimine
					pretomanid
					delamanid
fgd1	491001	c.219G>C	synonymous_variant	0.31	clofazimine
					pretomanid
					delamanid
fgd1	491007	c.225G>C	synonymous_variant	0.33	clofazimine
					pretomanid
					delamanid
fgd1	491013	c.231C>G	synonymous_variant	0.4	clofazimine
					pretomanid
					delamanid
fgd1	491043	c.261T>G	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fgd1	491049	c.267T>C	synonymous_variant	0.41	clofazimine
					pretomanid
					delamanid
fgd1	491742	c.960T>C	synonymous_variant	1.0	clofazimine	Not assoc w R
					pretomanid
					delamanid	Not assoc w R - Interim
mshA	575368	c.21T>C	synonymous_variant	1.0	ethionamide	Not assoc w R - Interim
mshA	575368	c.21T>C	synonymous_variant	1.0	isoniazid	Not assoc w R
mshA	575779	c.432A>G	synonymous_variant	0.44	ethionamide
mshA	575779	c.432A>G	synonymous_variant	0.44	isoniazid
mshA	575782	c.435G>C	synonymous_variant	0.44	ethionamide
mshA	575782	c.435G>C	synonymous_variant	0.44	isoniazid
mshA	575809	c.462C>T	synonymous_variant	0.56	ethionamide
mshA	575809	c.462C>T	synonymous_variant	0.56	isoniazid
mshA	575812	c.465C>T	synonymous_variant	0.53	ethionamide
mshA	575812	c.465C>T	synonymous_variant	0.53	isoniazid
mshA	575821	c.474G>C	synonymous_variant	0.53	ethionamide
mshA	575821	c.474G>C	synonymous_variant	0.53	isoniazid
mshA	575824	c.477T>G	synonymous_variant	0.53	ethionamide
mshA	575824	c.477T>G	synonymous_variant	0.53	isoniazid
mshA	575830	c.483C>G	synonymous_variant	0.53	ethionamide
mshA	575830	c.483C>G	synonymous_variant	0.53	isoniazid
mshA	575833	c.486C>G	synonymous_variant	0.53	ethionamide
mshA	575833	c.486C>G	synonymous_variant	0.53	isoniazid
mshA	575845	c.498C>T	synonymous_variant	0.53	ethionamide
mshA	575845	c.498C>T	synonymous_variant	0.53	isoniazid	Not assoc w R - Interim
mshA	575896	c.549G>C	synonymous_variant	0.5	ethionamide
mshA	575896	c.549G>C	synonymous_variant	0.5	isoniazid
mshA	575908	c.561A>G	synonymous_variant	0.5	ethionamide
mshA	575908	c.561A>G	synonymous_variant	0.5	isoniazid
ccsA	620682	c.792G>A	synonymous_variant	0.35	capreomycin
					amikacin
					kanamycin
ccsA	620688	c.798G>C	synonymous_variant	0.36	capreomycin
					amikacin
					kanamycin
ccsA	620710	c.820_822delGTGinsAA	frameshift_variant&missense_variant	0.35	capreomycin
					amikacin
					kanamycin
Rv0565c	657578	c.-108T>C	upstream_gene_variant	1.0	ethionamide
Rv0565c	657649	c.-179G>A	upstream_gene_variant	0.56	ethionamide
Rv0565c	657689	c.-220_-219delCAinsAC	upstream_gene_variant	0.5	ethionamide
Rv0565c	657701	c.-231C>G	upstream_gene_variant	0.44	ethionamide
hadA	732295	c.366G>C	synonymous_variant	0.44	isoniazid
hadA	732305	p.Ile126Val	missense_variant	0.41	isoniazid
hadA	732308	p.Val127Ile	missense_variant	0.44	isoniazid
hadA	732321	p.Glu131Ala	missense_variant	0.48	isoniazid
hadA	732329	p.Leu134Val	missense_variant	0.48	isoniazid	Uncertain significance
hadA	732337	c.408G>A	synonymous_variant	0.48	isoniazid
hadA	732378	c.450_452dupAGA	disruptive_inframe_insertion	0.48	isoniazid
hadA	732396	p.Gly156Ala	missense_variant	0.43	isoniazid
hadA	732398	p.Ala157Thr	missense_variant	0.48	isoniazid
nusG	734116	c.-138T>C	upstream_gene_variant	0.88	rifampicin	Not assoc w R
rpoB	760223	c.417T>C	synonymous_variant	0.29	rifampicin
rpoB	760235	c.429T>C	synonymous_variant	0.38	rifampicin	Not assoc w R - Interim
rpoB	760283	c.477G>C	synonymous_variant	0.36	rifampicin	Not assoc w R - Interim
rpoB	760298	c.492G>C	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoB	760307	c.501T>C	synonymous_variant	0.33	rifampicin
rpoB	760310	c.504G>C	synonymous_variant	0.33	rifampicin
rpoB	760328	c.522G>C	synonymous_variant	0.33	rifampicin
rpoB	760331	c.525G>C	synonymous_variant	0.33	rifampicin
rpoB	760340	c.534G>T	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoB	760361	c.555T>C	synonymous_variant	0.4	rifampicin	Not assoc w R - Interim
rpoB	760370	c.564C>G	synonymous_variant	0.47	rifampicin
rpoB	760376	p.Asp190Glu	missense_variant	0.45	rifampicin	Uncertain significance
rpoB	760380	p.Thr192Leu	missense_variant	0.45	rifampicin
rpoB	760406	c.600G>C	synonymous_variant	0.58	rifampicin
rpoB	760412	c.606C>G	synonymous_variant	0.62	rifampicin
rpoB	760424	c.618C>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoB	760430	c.624T>C	synonymous_variant	0.61	rifampicin	Not assoc w R - Interim
rpoB	760475	c.669A>G	synonymous_variant	0.63	rifampicin	Not assoc w R - Interim
rpoB	760481	c.675G>C	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoB	760484	c.678A>G	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoB	760522	p.Ser239Asn	missense_variant	0.39	rifampicin	Uncertain significance
rpoB	760532	c.726T>C	synonymous_variant	0.36	rifampicin	Not assoc w R - Interim
rpoB	760533	p.Val243Thr	missense_variant	0.36	rifampicin
rpoB	760541	c.735G>C	synonymous_variant	0.36	rifampicin	Not assoc w R - Interim
rpoB	760547	c.741G>C	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoB	760925	c.1119T>C	synonymous_variant	0.36	rifampicin
rpoB	760946	c.1140A>G	synonymous_variant	0.37	rifampicin	Not assoc w R - Interim
rpoB	761036	c.1230G>C	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoB	761037	c.1231T>C	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoB	761057	c.1251G>C	synonymous_variant	0.28	rifampicin	Not assoc w R - Interim
rpoB	761102	c.1296A>G	synonymous_variant	0.43	rifampicin
rpoB	761129	c.1323G>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoB	761132	c.1326G>T	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoB	761133	c.1327T>C	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoB	761150	c.1344A>C	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoB	761153	c.1347G>C	synonymous_variant	0.43	rifampicin
rpoB	761165	c.1359G>C	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoB	761180	c.1374A>C	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoB	761189	c.1383T>C	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoB	761195	c.1389G>C	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoB	761207	c.1401C>T	synonymous_variant	0.4	rifampicin
rpoB	761213	c.1407G>C	synonymous_variant	0.4	rifampicin
rpoB	761219	c.1413G>C	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoB	761249	c.1443A>G	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoB	761255	c.1449T>G	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoB	761261	c.1455G>T	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoB	761306	c.1500C>G	synonymous_variant	0.28	rifampicin
rpoB	761312	c.1506G>C	synonymous_variant	0.29	rifampicin
rpoB	761327	c.1521A>G	synonymous_variant	0.29	rifampicin	Not assoc w R - Interim
rpoB	761330	c.1524G>C	synonymous_variant	0.29	rifampicin
rpoB	761354	c.1548C>T	synonymous_variant	0.32	rifampicin
rpoB	761573	c.1767C>G	synonymous_variant	0.21	rifampicin	Not assoc w R - Interim
rpoB	761579	c.1773G>C	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoB	761588	c.1782C>T	synonymous_variant	0.3	rifampicin
rpoB	761606	c.1800C>G	synonymous_variant	0.39	rifampicin
rpoB	761612	c.1806G>C	synonymous_variant	0.39	rifampicin	Not assoc w R - Interim
rpoB	761615	c.1809A>C	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoB	761636	c.1830G>T	synonymous_variant	0.39	rifampicin	Not assoc w R - Interim
rpoB	761645	c.1839C>G	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoB	761648	c.1842T>C	synonymous_variant	0.35	rifampicin
rpoB	761657	c.1851C>G	synonymous_variant	0.37	rifampicin	Not assoc w R - Interim
rpoB	761675	c.1869G>C	synonymous_variant	0.44	rifampicin
rpoB	761791	p.Arg662His	missense_variant	0.47	rifampicin
rpoB	761813	c.2007T>C	synonymous_variant	0.44	rifampicin
rpoB	761815	p.Ala670Glu	missense_variant	0.44	rifampicin
rpoB	761852	c.2046C>G	synonymous_variant	0.44	rifampicin
rpoB	761858	c.2052G>C	synonymous_variant	0.35	rifampicin
rpoB	761873	c.2067A>C	synonymous_variant	0.44	rifampicin
rpoB	761885	c.2079T>C	synonymous_variant	0.42	rifampicin
rpoB	761906	c.2100C>G	synonymous_variant	0.45	rifampicin
rpoB	761909	c.2103T>C	synonymous_variant	0.45	rifampicin
rpoB	761912	c.2106T>C	synonymous_variant	0.47	rifampicin
rpoB	761915	p.Asp703Glu	missense_variant	0.47	rifampicin
rpoB	761916	p.Asp704Asn	missense_variant	0.47	rifampicin
rpoB	761948	c.2142G>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoB	761954	c.2148C>G	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoB	762008	c.2202C>T	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoB	762014	c.2208C>T	synonymous_variant	0.35	rifampicin
rpoB	762017	c.2211A>G	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoB	762083	c.2277T>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoB	762086	c.2280G>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoB	762101	c.2295C>G	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoB	762799	p.Ala998Gly	missense_variant	0.55	rifampicin	Uncertain significance
rpoB	762810	c.3004_3006delGCCinsTG	frameshift_variant&missense_variant	0.55	rifampicin
rpoB	762813	p.Met1003Val	missense_variant	0.55	rifampicin
rpoB	762818	c.3012C>G	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoB	762827	c.3021G>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	762857	c.3051C>G	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoB	762860	c.3054G>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoB	762863	c.3057T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	762926	c.3120C>T	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoB	762929	c.3123G>C	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
rpoC	762989	c.-381G>C	upstream_gene_variant	0.42	rifampicin
rpoB	762995	c.3189G>T	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoC	763013	c.-357C>G	upstream_gene_variant	0.47	rifampicin
rpoC	763025	c.-345C>T	upstream_gene_variant	0.53	rifampicin
rpoB	763028	c.3222T>C	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoB	763034	c.3228C>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoB	763040	c.3234C>G	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoB	763070	c.3264T>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoB	763085	c.3279C>G	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	763115	c.3309T>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoB	763136	c.3330C>T	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	763148	c.-222G>C	upstream_gene_variant	0.75	rifampicin
rpoC	763158	c.-212C>T	upstream_gene_variant	0.81	rifampicin
rpoB	763166	c.3360A>G	synonymous_variant	0.81	rifampicin	Not assoc w R - Interim
rpoC	763190	c.-180C>T	upstream_gene_variant	0.69	rifampicin
rpoC	763202	c.-168A>G	upstream_gene_variant	0.56	rifampicin
rpoC	763205	c.-165G>C	upstream_gene_variant	0.53	rifampicin
rpoC	763206	c.-164_-162delAGTinsTCG	upstream_gene_variant	0.6	rifampicin
rpoB	763214	c.3408T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoC	763226	c.-144A>G	upstream_gene_variant	0.56	rifampicin
rpoB	763227	c.3421C>T	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoB	763238	c.3432T>C	synonymous_variant	0.45	rifampicin	Not assoc w R - Interim
rpoC	763253	c.-117G>C	upstream_gene_variant	0.35	rifampicin
rpoC	763256	c.-114G>A	upstream_gene_variant	0.35	rifampicin
rpoB	763268	c.3462C>G	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoB	763283	c.3477T>C	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoC	763284	c.-86C>T	upstream_gene_variant	0.32	rifampicin
rpoC	763486	c.117T>G	synonymous_variant	0.33	rifampicin
rpoC	763531	c.162G>C	synonymous_variant	0.83	rifampicin	Not assoc w R
rpoC	763594	c.225C>T	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
rpoC	763603	c.234C>T	synonymous_variant	0.4	rifampicin	Not assoc w R - Interim
rpoC	763636	c.267T>C	synonymous_variant	0.54	rifampicin
rpoC	763660	c.291T>G	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoC	763675	c.306C>G	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoC	763696	c.327T>C	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoC	763702	c.333C>G	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoC	763717	c.348T>C	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoC	763723	c.354G>C	synonymous_variant	0.56	rifampicin
rpoC	763732	c.363C>G	synonymous_variant	0.53	rifampicin
rpoC	763741	c.372C>T	synonymous_variant	0.6	rifampicin
rpoC	763744	c.375G>C	synonymous_variant	0.54	rifampicin
rpoC	763765	c.396T>C	synonymous_variant	0.61	rifampicin
rpoC	763774	c.405G>C	synonymous_variant	0.56	rifampicin
rpoC	763807	c.438T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	763816	c.447C>G	synonymous_variant	0.6	rifampicin
rpoC	763835	p.Ala156Met	missense_variant	0.62	rifampicin
rpoC	763853	p.Val162Ile	missense_variant	0.44	rifampicin
rpoC	763858	c.489A>G	synonymous_variant	0.47	rifampicin
rpoC	763872	p.Gly168Ala	missense_variant	0.53	rifampicin
rpoC	763876	p.Glu169Asp	missense_variant	0.53	rifampicin
rpoC	763879	c.510A>G	synonymous_variant	0.57	rifampicin
rpoC	763884	p.Ala172Val	missense_variant	0.5	rifampicin	Not assoc w R
rpoC	763886	c.517_519delCGGinsAC	frameshift_variant&missense_variant	0.5	rifampicin
rpoC	763987	c.618C>T	synonymous_variant	0.41	rifampicin
rpoC	763991	c.622_624delATCinsCG	frameshift_variant&missense_variant	0.41	rifampicin
rpoC	763996	c.627T>C	synonymous_variant	0.41	rifampicin
rpoC	764002	c.633C>G	synonymous_variant	0.41	rifampicin
rpoC	764005	c.636G>C	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoC	764024	c.655_657delTTGinsCC	frameshift_variant&missense_variant	0.43	rifampicin
rpoC	764032	p.Asp221Glu	missense_variant	0.43	rifampicin
rpoC	764040	p.Ser224Thr	missense_variant	0.43	rifampicin
rpoC	764044	c.675T>C	synonymous_variant	0.45	rifampicin
rpoC	764059	c.690G>T	synonymous_variant	0.42	rifampicin
rpoC	764083	c.714A>G	synonymous_variant	0.43	rifampicin
rpoC	764098	c.729A>G	synonymous_variant	0.4	rifampicin	Not assoc w R - Interim
rpoC	764101	c.732C>G	synonymous_variant	0.4	rifampicin	Not assoc w R - Interim
rpoC	764102	p.Val245Ile	missense_variant	0.4	rifampicin
rpoC	764112	p.Tyr248Phe	missense_variant	0.38	rifampicin
rpoC	764116	c.747C>T	synonymous_variant	0.38	rifampicin	Not assoc w R - Interim
rpoC	764131	c.762T>C	synonymous_variant	0.42	rifampicin
rpoC	764203	c.834G>C	synonymous_variant	0.57	rifampicin
rpoC	764206	c.837T>C	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoC	764215	c.846A>G	synonymous_variant	0.62	rifampicin
rpoC	764236	c.867G>A	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	764248	c.879C>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoC	764257	c.888G>C	synonymous_variant	0.62	rifampicin
rpoC	764266	c.897T>C	synonymous_variant	0.73	rifampicin
rpoC	764269	c.900G>C	synonymous_variant	0.73	rifampicin
rpoC	764272	c.903G>C	synonymous_variant	0.73	rifampicin
rpoC	764278	c.909A>G	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	764338	c.969G>A	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoC	764353	c.984G>C	synonymous_variant	0.44	rifampicin
rpoC	764365	c.996C>T	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoC	764380	c.1011G>C	synonymous_variant	0.38	rifampicin	Not assoc w R - Interim
rpoC	764381	c.1012_1013delTCinsAG	synonymous_variant	0.38	rifampicin
rpoC	764387	c.1018_1020delTTGinsCC	frameshift_variant&missense_variant	0.38	rifampicin
rpoC	764405	c.1036A>C	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoC	764419	c.1050C>G	synonymous_variant	0.43	rifampicin
rpoC	764428	c.1059G>C	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
rpoC	764431	c.1062G>C	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
rpoC	764434	c.1065A>G	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
rpoC	764446	c.1077T>C	synonymous_variant	0.43	rifampicin
rpoC	764449	c.1080G>C	synonymous_variant	0.43	rifampicin
rpoC	764452	c.1083T>C	synonymous_variant	0.43	rifampicin
rpoC	764458	c.1089G>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	764593	c.1224C>T	synonymous_variant	0.5	rifampicin
rpoC	764611	c.1242G>T	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	764650	c.1281G>C	synonymous_variant	0.53	rifampicin
rpoC	764651	c.1282_1284delTCGinsAGC	synonymous_variant	0.53	rifampicin
rpoC	764752	c.1383G>C	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoC	764764	c.1395T>C	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoC	764809	c.1440C>T	synonymous_variant	1.0	rifampicin	Not assoc w R
rpoC	764815	c.1446A>G	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
rpoC	764827	c.1458G>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	764858	c.1489T>C	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoC	764872	c.1503A>G	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoC	764888	c.1519T>C	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
rpoC	764911	c.1542A>G	synonymous_variant	0.45	rifampicin
rpoC	764932	c.1563C>A	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
rpoC	764935	c.1566T>C	synonymous_variant	0.43	rifampicin
rpoC	764948	c.1579T>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	764968	c.1599T>C	synonymous_variant	0.36	rifampicin	Not assoc w R - Interim
rpoC	764995	c.1626C>G	synonymous_variant	0.31	rifampicin	Not assoc w R
rpoC	765019	c.1650A>G	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoC	765034	c.1665T>C	synonymous_variant	0.26	rifampicin
rpoC	765040	c.1671T>C	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoC	765041	c.1672T>C	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoC	765047	c.1678T>C	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoC	765053	c.1684_1685delTCinsAG	synonymous_variant	0.26	rifampicin
rpoC	765089	c.1720T>C	synonymous_variant	0.32	rifampicin	Not assoc w R - Interim
rpoC	765292	c.1923G>C	synonymous_variant	0.42	rifampicin
rpoC	765298	c.1929G>C	synonymous_variant	0.33	rifampicin
rpoC	765300	p.Val644Ala	missense_variant	0.33	rifampicin	Uncertain significance
rpoC	765319	c.1950A>G	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoC	765326	p.His653Ala	missense_variant	0.42	rifampicin	Uncertain significance
rpoC	765329	p.Ser654Gly	missense_variant	0.42	rifampicin
rpoC	765346	c.1977C>G	synonymous_variant	0.42	rifampicin
rpoC	765349	c.1980T>C	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
rpoC	765352	c.1983G>C	synonymous_variant	0.48	rifampicin	Not assoc w R - Interim
rpoC	765383	p.Met672Leu	missense_variant	0.54	rifampicin	Uncertain significance
rpoC	765404	p.Leu679Val	missense_variant	0.63	rifampicin
rpoC	765409	c.2040T>C	synonymous_variant	0.63	rifampicin
rpoC	765421	c.2052C>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoC	765478	c.2109T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	765499	c.2130C>G	synonymous_variant	0.68	rifampicin	Not assoc w R - Interim
rpoC	765529	c.2160C>T	synonymous_variant	0.66	rifampicin
rpoC	765541	c.2172C>G	synonymous_variant	0.57	rifampicin
rpoC	765553	c.2184C>T	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoC	765556	c.2187G>C	synonymous_variant	0.56	rifampicin
rpoC	765559	c.2190G>C	synonymous_variant	0.56	rifampicin
rpoC	765580	c.2211G>C	synonymous_variant	0.62	rifampicin
rpoC	765613	p.His748Gln	missense_variant	0.48	rifampicin
rpoC	765625	c.2256C>G	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	765631	p.Asp754Glu	missense_variant	0.52	rifampicin
rpoC	765700	c.2331T>C	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoC	765734	c.2365T>C	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoC	765739	c.2370G>T	synonymous_variant	0.58	rifampicin
rpoC	765751	c.2382C>G	synonymous_variant	0.56	rifampicin
rpoC	765753	p.Asp795Ala	missense_variant	0.52	rifampicin	Uncertain significance
rpoC	765772	c.2403C>G	synonymous_variant	0.59	rifampicin
rpoC	765784	c.2415C>G	synonymous_variant	0.56	rifampicin
rpoC	765787	c.2418C>T	synonymous_variant	0.54	rifampicin
rpoC	765793	c.2424C>G	synonymous_variant	0.54	rifampicin
rpoC	765796	c.2427C>T	synonymous_variant	0.54	rifampicin
rpoC	765811	c.2442T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	765814	c.2445A>G	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	765826	c.2457T>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoC	765883	c.2514C>G	synonymous_variant	0.59	rifampicin
rpoC	765886	c.2517C>G	synonymous_variant	0.59	rifampicin
rpoC	765892	c.2523T>C	synonymous_variant	0.59	rifampicin	Not assoc w R - Interim
rpoC	765937	c.2568T>C	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoC	765967	c.2598C>T	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoC	765982	c.2613C>G	synonymous_variant	0.48	rifampicin
rpoC	765994	c.2625A>T	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoC	766010	c.2641_2642delTCinsAG	synonymous_variant	0.4	rifampicin
rpoC	766021	c.2652G>C	synonymous_variant	0.41	rifampicin
rpoC	766027	c.2658G>C	synonymous_variant	0.46	rifampicin
rpoC	766030	c.2661C>G	synonymous_variant	0.46	rifampicin
rpoC	766043	p.Gln892Glu	missense_variant	0.48	rifampicin
rpoC	766054	c.2685C>G	synonymous_variant	0.43	rifampicin
rpoC	766082	p.Ala905Gln	missense_variant	0.41	rifampicin
rpoC	766096	c.2727G>C	synonymous_variant	0.45	rifampicin
rpoC	766129	c.2760C>G	synonymous_variant	0.44	rifampicin
rpoC	766135	c.2766G>A	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoC	766141	c.2772C>T	synonymous_variant	0.44	rifampicin
rpoC	766142	c.2773C>T	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoC	766174	p.Asn935Lys	missense_variant	0.45	rifampicin
rpoC	766178	p.Ile937Val	missense_variant	0.45	rifampicin
rpoC	766185	p.Glu939Ala	missense_variant	0.44	rifampicin
rpoC	766258	c.2889T>C	synonymous_variant	0.42	rifampicin
rpoC	766273	c.2904T>C	synonymous_variant	0.4	rifampicin
rpoC	766274	p.Ala969Thr	missense_variant	0.4	rifampicin
rpoC	766280	p.Ser971Gly	missense_variant	0.4	rifampicin
rpoC	766390	c.3021C>T	synonymous_variant	0.41	rifampicin
rpoC	766426	c.3057C>T	synonymous_variant	0.38	rifampicin
rpoC	766447	c.3078T>C	synonymous_variant	0.38	rifampicin
rpoC	766462	c.3093G>C	synonymous_variant	0.36	rifampicin
rpoC	766726	c.3357T>C	synonymous_variant	0.5	rifampicin
rpoC	766738	c.3369G>C	synonymous_variant	0.53	rifampicin
rpoC	766765	c.3396A>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	766774	c.3405T>C	synonymous_variant	0.7	rifampicin
rpoC	766801	c.3432C>G	synonymous_variant	0.6	rifampicin
rpoC	766804	c.3435A>G	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoC	766861	c.3492G>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	766864	c.3495G>C	synonymous_variant	0.6	rifampicin
rpoC	766876	c.3507C>T	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	766882	c.3513C>T	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	766894	c.3525T>C	synonymous_variant	0.55	rifampicin
rpoC	766895	c.3526T>C	synonymous_variant	0.5	rifampicin
rpoC	766900	c.3531T>C	synonymous_variant	0.5	rifampicin
rpoC	766933	c.3564A>G	synonymous_variant	0.52	rifampicin
rpoC	766945	c.3576A>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	766963	c.3594T>C	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoC	766972	c.3603G>C	synonymous_variant	0.85	rifampicin
rpoC	766996	c.3627C>T	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoC	767009	c.3640_3642delTCGinsAGC	synonymous_variant	0.85	rifampicin
rpoC	767014	c.3645G>C	synonymous_variant	0.85	rifampicin
rpoC	767033	c.3664_3666delTCGinsAGT	synonymous_variant	0.85	rifampicin
rpoC	767059	c.3690T>G	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoC	767062	c.3693C>A	synonymous_variant	0.8	rifampicin
rpoC	767098	c.3729T>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	767119	c.3750A>G	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoC	767134	c.3765C>A	synonymous_variant	0.67	rifampicin
rpoC	767158	c.3789T>C	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
rpoC	767180	p.Ala1271Gln	missense_variant	0.5	rifampicin
rpoC	767191	c.3822C>G	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
rpsL	781700	c.141G>C	synonymous_variant	0.29	streptomycin
rpsL	781703	c.144G>T	synonymous_variant	0.29	streptomycin
rpsL	781715	c.156T>C	synonymous_variant	0.27	streptomycin
rpsL	781728	c.169T>C	synonymous_variant	0.31	streptomycin
rpsL	781736	c.177T>C	synonymous_variant	0.31	streptomycin
rpsL	781742	c.183C>T	synonymous_variant	0.32	streptomycin
rpsL	781748	c.189C>G	synonymous_variant	0.29	streptomycin
rpsL	781754	c.195G>C	synonymous_variant	0.27	streptomycin
rpsL	781760	c.201T>C	synonymous_variant	0.29	streptomycin
rpsL	781772	c.213C>A	synonymous_variant	0.25	streptomycin
rpsL	781808	c.249C>T	synonymous_variant	0.25	streptomycin
rpsL	781811	c.252C>T	synonymous_variant	0.22	streptomycin
rpsL	781832	c.273T>C	synonymous_variant	0.21	streptomycin
rpsL	781838	c.279G>C	synonymous_variant	0.27	streptomycin
rpsL	781841	c.282C>G	synonymous_variant	0.26	streptomycin
rpsL	781865	c.306G>C	synonymous_variant	0.22	streptomycin
rpsL	781868	c.309T>C	synonymous_variant	0.23	streptomycin
rpsL	781871	c.312G>C	synonymous_variant	0.23	streptomycin
rpsL	781877	c.318T>C	synonymous_variant	0.25	streptomycin
rpsL	781892	c.333A>G	synonymous_variant	0.27	streptomycin
rpsL	781898	c.339A>T	synonymous_variant	0.22	streptomycin
rpsL	781916	c.357T>C	synonymous_variant	0.26	streptomycin
rpsL	781929	p.Gly124Ser	missense_variant	0.35	streptomycin	Uncertain significance
rplC	800357	c.-452C>A	upstream_gene_variant	1.0	linezolid	Not assoc w R
rplC	800516	c.-293G>T	upstream_gene_variant	0.4	linezolid
rplC	800537	c.-272C>T	upstream_gene_variant	0.47	linezolid
rplC	800540	c.-269T>C	upstream_gene_variant	0.47	linezolid
rplC	800546	c.-263T>G	upstream_gene_variant	0.45	linezolid
rplC	800567	c.-242A>G	upstream_gene_variant	0.47	linezolid
rplC	800582	c.-227C>G	upstream_gene_variant	0.5	linezolid
rplC	800612	c.-197A>G	upstream_gene_variant	0.31	linezolid
rplC	800618	c.-191T>C	upstream_gene_variant	0.31	linezolid
rplC	800627	c.-182C>T	upstream_gene_variant	0.28	linezolid
rplC	800648	c.-161A>T	upstream_gene_variant	0.35	linezolid
rplC	800654	c.-155T>C	upstream_gene_variant	0.35	linezolid
rplC	800693	c.-116A>G	upstream_gene_variant	0.39	linezolid
rplC	800703	c.-106T>C	upstream_gene_variant	0.31	linezolid
rplC	800715	c.-94A>C	upstream_gene_variant	0.36	linezolid
rplC	800720	c.-89T>C	upstream_gene_variant	0.36	linezolid
rplC	800723	c.-86C>G	upstream_gene_variant	0.36	linezolid
rplC	800747	c.-62C>G	upstream_gene_variant	0.4	linezolid
rplC	800771	c.-38C>T	upstream_gene_variant	0.44	linezolid
rplC	800814	c.6A>G	synonymous_variant	0.4	linezolid
rplC	800817	c.9A>T	synonymous_variant	0.42	linezolid
rplC	800907	c.99C>G	synonymous_variant	0.27	linezolid
rplC	800916	c.108A>G	synonymous_variant	0.31	linezolid
rplC	800934	c.126C>G	synonymous_variant	0.31	linezolid
rplC	800937	c.129A>G	synonymous_variant	0.31	linezolid
rplC	800939	p.Arg44Gln	missense_variant	0.31	linezolid
rplC	800946	c.138T>C	synonymous_variant	0.29	linezolid
rplC	800949	c.141T>C	synonymous_variant	0.29	linezolid
rplC	800967	c.159C>G	synonymous_variant	0.31	linezolid
rplC	800970	c.162T>C	synonymous_variant	0.31	linezolid	Not assoc w R - Interim
rplC	801339	c.531T>C	synonymous_variant	0.45	linezolid
rplC	801341	p.Leu178Gln	missense_variant	0.45	linezolid
rplC	801348	c.540T>G	synonymous_variant	0.45	linezolid
rplC	801357	c.549T>C	synonymous_variant	0.45	linezolid
rplC	801367	p.Ala187Thr	missense_variant	0.5	linezolid
rplC	801402	c.594T>C	synonymous_variant	0.43	linezolid
rplC	801405	c.597T>C	synonymous_variant	0.42	linezolid
rplC	801423	c.615G>C	synonymous_variant	0.38	linezolid
rplC	801426	c.618C>G	synonymous_variant	0.39	linezolid
rplC	801427	p.Met207Val	missense_variant	0.39	linezolid
rplC	801438	c.630T>C	synonymous_variant	0.36	linezolid
rplC	801442	p.Ile212Val	missense_variant	0.39	linezolid
Rv1129c	1254562	c.-28T>C	upstream_gene_variant	1.0	moxifloxacin	Not assoc w R
					levofloxacin	Not assoc w R
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
fbiC	1302821	c.-110G>A	upstream_gene_variant	1.0	clofazimine	Uncertain significance
					pretomanid
					delamanid	Uncertain significance
fbiC	1303632	c.702T>G	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1303641	c.711C>T	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1303650	c.720G>C	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1303654	c.724C>T	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1303659	c.729T>C	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1303661	p.Val244Ala	missense_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1303663	c.733C>T	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1303671	c.741C>T	synonymous_variant	0.33	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid
fbiC	1303674	c.744C>G	synonymous_variant	0.33	clofazimine
					pretomanid
					delamanid
fbiC	1303681	c.751T>C	synonymous_variant	0.35	clofazimine
					pretomanid
					delamanid
fbiC	1303686	c.756C>G	synonymous_variant	0.35	clofazimine
					pretomanid
					delamanid
fbiC	1303695	c.765T>C	synonymous_variant	0.37	clofazimine
					pretomanid
					delamanid
fbiC	1303905	c.975G>C	synonymous_variant	0.58	clofazimine
					pretomanid
					delamanid
fbiC	1303914	c.984C>G	synonymous_variant	0.58	clofazimine
					pretomanid
					delamanid
fbiC	1304559	p.Glu543Asp	missense_variant	0.35	clofazimine
					pretomanid
					delamanid
fbiC	1304565	c.1635C>G	synonymous_variant	0.32	clofazimine
					pretomanid
					delamanid
fbiC	1304568	c.1638T>C	synonymous_variant	0.33	clofazimine
					pretomanid
					delamanid
fbiC	1304580	c.1650T>C	synonymous_variant	0.35	clofazimine
					pretomanid
					delamanid
fbiC	1304613	c.1683T>C	synonymous_variant	0.62	clofazimine
					pretomanid
					delamanid
fbiC	1304634	c.1704C>G	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304640	c.1710A>C	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304646	c.1716T>C	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304658	c.1728C>G	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304661	c.1731C>T	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304670	c.1740G>C	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304671	p.Val581Thr	missense_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304675	p.Gly582Asp	missense_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304691	c.1761G>C	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304694	c.1764A>C	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304703	c.1773C>G	synonymous_variant	0.71	clofazimine
					pretomanid
					delamanid
fbiC	1304711	p.Ala594Glu	missense_variant	0.8	clofazimine
					pretomanid
					delamanid
fbiC	1304715	c.1785G>C	synonymous_variant	0.8	clofazimine
					pretomanid
					delamanid
fbiC	1304724	c.1794A>G	synonymous_variant	0.62	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1304727	c.1797A>G	synonymous_variant	0.5	clofazimine
					pretomanid
					delamanid
fbiC	1304739	c.1809C>T	synonymous_variant	0.42	clofazimine
					pretomanid
					delamanid
fbiC	1304742	c.1812T>C	synonymous_variant	0.43	clofazimine
					pretomanid
					delamanid
fbiC	1304757	c.1827A>G	synonymous_variant	0.33	clofazimine
					pretomanid
					delamanid
fbiC	1304778	c.1848T>C	synonymous_variant	0.41	clofazimine
					pretomanid
					delamanid
fbiC	1304784	c.1854T>C	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1304787	c.1857T>G	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1304808	c.1878C>G	synonymous_variant	0.37	clofazimine
					pretomanid
					delamanid
fbiC	1304811	c.1881C>G	synonymous_variant	0.37	clofazimine
					pretomanid
					delamanid
fbiC	1304817	c.1887T>C	synonymous_variant	0.36	clofazimine
					pretomanid
					delamanid
fbiC	1304832	c.1902C>T	synonymous_variant	0.35	clofazimine	Not assoc w R - Interim
					pretomanid
					delamanid	Not assoc w R - Interim
fbiC	1304856	c.1926C>G	synonymous_variant	0.37	clofazimine
					pretomanid
					delamanid
fbiC	1304862	c.1932G>A	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1304869	c.1939C>T	synonymous_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1304875	p.Ile649Val	missense_variant	0.35	clofazimine
					pretomanid
					delamanid
fbiC	1304883	p.Glu651Asp	missense_variant	0.42	clofazimine
					pretomanid
					delamanid
fbiC	1304891	p.Ile654Thr	missense_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1304893	p.Gly655Ser	missense_variant	0.38	clofazimine
					pretomanid
					delamanid
fbiC	1304907	c.1977C>G	synonymous_variant	0.45	clofazimine
					pretomanid
					delamanid
fbiC	1304910	c.1980G>C	synonymous_variant	0.48	clofazimine
					pretomanid
					delamanid
fbiC	1304916	c.1986T>C	synonymous_variant	0.5	clofazimine
					pretomanid
					delamanid
fbiC	1304928	c.1998T>C	synonymous_variant	0.6	clofazimine
					pretomanid
					delamanid
fbiC	1304937	c.2007G>C	synonymous_variant	0.6	clofazimine
					pretomanid
					delamanid
fbiC	1304958	c.2028T>G	synonymous_variant	0.55	clofazimine
					pretomanid
					delamanid
fbiC	1304983	c.2053C>T	synonymous_variant	0.53	clofazimine
					pretomanid
					delamanid
fbiC	1304994	c.2064A>G	synonymous_variant	0.45	clofazimine
					pretomanid
					delamanid
fbiC	1304995	p.Leu689Met	missense_variant	0.45	clofazimine
					pretomanid
					delamanid
fbiC	1305006	c.2076A>G	synonymous_variant	0.45	clofazimine
					pretomanid
					delamanid
Rv1258c	1406312	c.1029T>C	synonymous_variant	1.0	streptomycin	Not assoc w R
					isoniazid	Not assoc w R
					pyrazinamide	Not assoc w R
embR	1417554	c.-207C>G	upstream_gene_variant	1.0	ethambutol
embR	1417793	c.-446C>T	upstream_gene_variant	1.0	ethambutol
rrs	1471923	n.78T>C	non_coding_transcript_exon_variant	0.34	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471925	n.80T>C	non_coding_transcript_exon_variant	0.34	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471932	n.87A>G	non_coding_transcript_exon_variant	0.36	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1471934	n.89A>G	non_coding_transcript_exon_variant	0.36	streptomycin	Uncertain significance
					kanamycin
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471969	n.124T>C	non_coding_transcript_exon_variant	0.33	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471970	n.125G>A	non_coding_transcript_exon_variant	0.33	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472028	n.183A>T	non_coding_transcript_exon_variant	0.32	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472029	n.184C>T	non_coding_transcript_exon_variant	0.32	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472030	n.185G>T	non_coding_transcript_exon_variant	0.3	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472031	n.186G>A	non_coding_transcript_exon_variant	0.3	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472033	n.188A>G	non_coding_transcript_exon_variant	0.27	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472034	n.189T>C	non_coding_transcript_exon_variant	0.27	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472044	n.199G>T	non_coding_transcript_exon_variant	0.32	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472045	n.200T>A	non_coding_transcript_exon_variant	0.32	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472053	n.211_212delGC	non_coding_transcript_exon_variant	0.32	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472061	n.216A>T	non_coding_transcript_exon_variant	0.32	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472075	n.230A>G	non_coding_transcript_exon_variant	0.41	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472108	n.263C>T	non_coding_transcript_exon_variant	0.33	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472300	n.455C>T	non_coding_transcript_exon_variant	0.53	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473290	n.1445C>T	non_coding_transcript_exon_variant	0.8	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1473756	n.99G>A	non_coding_transcript_exon_variant	0.6	capreomycin
rrl	1473756	n.99G>A	non_coding_transcript_exon_variant	0.6	linezolid
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	0.6	capreomycin	Uncertain significance
rrl	1473758	n.101G>T	non_coding_transcript_exon_variant	0.6	linezolid
rrl	1473877	n.220G>A	non_coding_transcript_exon_variant	0.5	capreomycin
rrl	1473877	n.220G>A	non_coding_transcript_exon_variant	0.5	linezolid
rrl	1473898	n.241C>T	non_coding_transcript_exon_variant	0.53	capreomycin	Uncertain significance
rrl	1473898	n.241C>T	non_coding_transcript_exon_variant	0.53	linezolid	Uncertain significance
rrl	1473899	n.242A>C	non_coding_transcript_exon_variant	0.53	capreomycin	Uncertain significance
rrl	1473899	n.242A>C	non_coding_transcript_exon_variant	0.53	linezolid	Uncertain significance
rrl	1473943	n.286G>T	non_coding_transcript_exon_variant	0.58	capreomycin	Uncertain significance
rrl	1473943	n.286G>T	non_coding_transcript_exon_variant	0.58	linezolid
rrl	1473986	n.329T>C	non_coding_transcript_exon_variant	0.65	capreomycin
rrl	1473986	n.329T>C	non_coding_transcript_exon_variant	0.65	linezolid
rrl	1473987	n.330G>A	non_coding_transcript_exon_variant	0.65	capreomycin
rrl	1473987	n.330G>A	non_coding_transcript_exon_variant	0.65	linezolid
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	0.65	capreomycin
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	0.65	linezolid
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	0.53	capreomycin	Not assoc w R
rrl	1474001	n.344C>T	non_coding_transcript_exon_variant	0.53	linezolid	Not assoc w R
rrl	1474009	n.352A>G	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1474009	n.352A>G	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1474012	n.355C>T	non_coding_transcript_exon_variant	0.62	capreomycin
rrl	1474012	n.355C>T	non_coding_transcript_exon_variant	0.62	linezolid
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1474181	n.524C>T	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1474181	n.524C>T	non_coding_transcript_exon_variant	0.75	linezolid
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1474291	n.635_649delTTCCTCTCCGGAGGA	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1474291	n.635_649delTTCCTCTCCGGAGGA	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1474308	n.651G>T	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1474308	n.651G>T	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1474310	n.653T>G	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1474310	n.653T>G	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1475313	n.1656G>A	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1475313	n.1656G>A	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1475315	n.1658A>T	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1475315	n.1658A>T	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	0.86	capreomycin
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	0.86	linezolid
rrl	1475402	n.1745C>T	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1475402	n.1745C>T	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.7	linezolid
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	0.65	capreomycin	Uncertain significance
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	0.65	linezolid	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.64	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.64	linezolid	Uncertain significance
rrl	1476031	n.2374C>T	non_coding_transcript_exon_variant	0.59	capreomycin
rrl	1476031	n.2374C>T	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1476032	n.2375C>A	non_coding_transcript_exon_variant	0.59	capreomycin
rrl	1476032	n.2375C>A	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1476034	n.2377C>A	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1476034	n.2377C>A	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	0.56	capreomycin	Uncertain significance
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	0.56	linezolid
rrl	1476047	n.2390G>T	non_coding_transcript_exon_variant	0.56	capreomycin
rrl	1476047	n.2390G>T	non_coding_transcript_exon_variant	0.56	linezolid
rrl	1476048	n.2391G>A	non_coding_transcript_exon_variant	0.56	capreomycin
rrl	1476048	n.2391G>A	non_coding_transcript_exon_variant	0.56	linezolid
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.56	capreomycin	Uncertain significance
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	0.56	linezolid	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	0.52	capreomycin	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	0.52	linezolid	Uncertain significance
rrl	1476089	n.2432T>C	non_coding_transcript_exon_variant	0.5	capreomycin
rrl	1476089	n.2432T>C	non_coding_transcript_exon_variant	0.5	linezolid
rrl	1476095	n.2438C>G	non_coding_transcript_exon_variant	0.5	capreomycin
rrl	1476095	n.2438C>G	non_coding_transcript_exon_variant	0.5	linezolid
rrl	1476105	n.2448_2449delGAinsT	non_coding_transcript_exon_variant	0.47	capreomycin
rrl	1476105	n.2448_2449delGAinsT	non_coding_transcript_exon_variant	0.47	linezolid
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.42	capreomycin	Uncertain significance
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.42	linezolid	Uncertain significance
rrl	1476117	n.2460G>C	non_coding_transcript_exon_variant	0.42	capreomycin
rrl	1476117	n.2460G>C	non_coding_transcript_exon_variant	0.42	linezolid
rrl	1476214	n.2557G>A	non_coding_transcript_exon_variant	0.36	capreomycin
rrl	1476214	n.2557G>A	non_coding_transcript_exon_variant	0.36	linezolid
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.38	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.38	linezolid	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.39	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.39	linezolid	Uncertain significance
fabG1	1673758	p.Lys107Glu	missense_variant	0.38	ethionamide
fabG1	1673758	p.Lys107Glu	missense_variant	0.38	isoniazid
inhA	1673901	c.-301A>G	upstream_gene_variant	0.32	ethionamide
inhA	1673901	c.-301A>G	upstream_gene_variant	0.32	isoniazid
fabG1	1673905	p.Ser156Ala	missense_variant	0.32	ethionamide
fabG1	1673905	p.Ser156Ala	missense_variant	0.32	isoniazid
inhA	1673916	c.-286A>C	upstream_gene_variant	0.27	ethionamide
inhA	1673916	c.-286A>C	upstream_gene_variant	0.27	isoniazid
fabG1	1673917	p.Val160Leu	missense_variant	0.27	ethionamide
fabG1	1673917	p.Val160Leu	missense_variant	0.27	isoniazid
inhA	1673922	c.-280T>C	upstream_gene_variant	0.27	ethionamide
inhA	1673922	c.-280T>C	upstream_gene_variant	0.27	isoniazid
inhA	1674162	c.-40C>T	upstream_gene_variant	0.8	ethionamide	Uncertain significance
inhA	1674162	c.-40C>T	upstream_gene_variant	0.8	isoniazid	Not assoc w R
rpsA	1833721	c.180A>G	synonymous_variant	0.29	pyrazinamide
rpsA	1833724	c.183C>G	synonymous_variant	0.29	pyrazinamide
rpsA	1833727	c.186G>C	synonymous_variant	0.29	pyrazinamide
rpsA	1833742	c.201A>G	synonymous_variant	0.31	pyrazinamide
rpsA	1833745	c.204G>C	synonymous_variant	0.33	pyrazinamide
rpsA	1833748	c.207C>G	synonymous_variant	0.32	pyrazinamide
rpsA	1833787	c.246C>G	synonymous_variant	0.37	pyrazinamide
rpsA	1833790	c.249T>C	synonymous_variant	0.38	pyrazinamide
rpsA	1833802	c.261A>G	synonymous_variant	0.48	pyrazinamide
rpsA	1833811	c.270G>T	synonymous_variant	0.45	pyrazinamide
rpsA	1833838	c.297G>C	synonymous_variant	0.52	pyrazinamide
rpsA	1833841	c.300C>G	synonymous_variant	0.55	pyrazinamide
rpsA	1833847	c.306C>G	synonymous_variant	0.58	pyrazinamide
rpsA	1833856	c.315A>G	synonymous_variant	0.58	pyrazinamide
rpsA	1833874	c.333T>C	synonymous_variant	0.56	pyrazinamide
rpsA	1833886	c.345C>G	synonymous_variant	0.57	pyrazinamide
rpsA	1833928	c.387G>C	synonymous_variant	0.58	pyrazinamide
rpsA	1833940	c.399C>G	synonymous_variant	0.68	pyrazinamide
rpsA	1833971	c.430C>T	synonymous_variant	0.65	pyrazinamide
rpsA	1833979	c.438T>C	synonymous_variant	0.65	pyrazinamide
rpsA	1834000	c.459G>C	synonymous_variant	0.52	pyrazinamide
rpsA	1834021	c.480C>T	synonymous_variant	0.48	pyrazinamide
rpsA	1834030	c.489C>G	synonymous_variant	0.44	pyrazinamide
rpsA	1834096	c.555G>C	synonymous_variant	0.33	pyrazinamide
rpsA	1834099	c.558C>G	synonymous_variant	0.33	pyrazinamide
rpsA	1834102	c.561T>C	synonymous_variant	0.33	pyrazinamide
rpsA	1834105	c.564C>G	synonymous_variant	0.33	pyrazinamide
rpsA	1834108	c.567C>G	synonymous_variant	0.33	pyrazinamide
rpsA	1834123	c.582C>G	synonymous_variant	0.33	pyrazinamide
rpsA	1834150	c.609G>C	synonymous_variant	0.32	pyrazinamide
rpsA	1834153	c.612T>C	synonymous_variant	0.32	pyrazinamide
rpsA	1834154	c.613_615delAACinsCG	frameshift_variant&missense_variant	0.35	pyrazinamide	Uncertain significance
rpsA	1834157	c.616T>C	synonymous_variant	0.35	pyrazinamide
rpsA	1834162	c.621A>G	synonymous_variant	0.35	pyrazinamide	Not assoc w R - Interim
rpsA	1834165	c.624A>G	synonymous_variant	0.36	pyrazinamide
rpsA	1834169	p.Thr210Ala	missense_variant	0.36	pyrazinamide	Uncertain significance
rpsA	1834177	c.636A>C	synonymous_variant	0.36	pyrazinamide	Not assoc w R - Interim
rpsA	1834189	c.648G>C	synonymous_variant	0.35	pyrazinamide
rpsA	1834195	c.654G>C	synonymous_variant	0.38	pyrazinamide
rpsA	1834210	c.669C>T	synonymous_variant	0.29	pyrazinamide
rpsA	1834222	c.681T>C	synonymous_variant	0.29	pyrazinamide
rpsA	1834231	c.690T>C	synonymous_variant	0.31	pyrazinamide
rpsA	1834234	c.693G>C	synonymous_variant	0.25	pyrazinamide
rpsA	1834249	c.708T>C	synonymous_variant	0.24	pyrazinamide
rpsA	1834264	c.723G>C	synonymous_variant	0.22	pyrazinamide
rpsA	1834303	c.762T>C	synonymous_variant	0.39	pyrazinamide
rpsA	1834306	c.765T>C	synonymous_variant	0.39	pyrazinamide
rpsA	1834348	c.807T>C	synonymous_variant	0.44	pyrazinamide	Not assoc w R - Interim
rpsA	1834366	c.825A>G	synonymous_variant	0.48	pyrazinamide	Not assoc w R - Interim
rpsA	1834396	c.855G>C	synonymous_variant	0.48	pyrazinamide
rpsA	1834411	c.870T>C	synonymous_variant	0.5	pyrazinamide
rpsA	1834417	c.876G>C	synonymous_variant	0.46	pyrazinamide
rpsA	1834423	c.882G>C	synonymous_variant	0.52	pyrazinamide
rpsA	1834435	c.894G>C	synonymous_variant	0.47	pyrazinamide
rpsA	1834451	c.910T>C	synonymous_variant	0.47	pyrazinamide
rpsA	1834465	c.924T>C	synonymous_variant	0.5	pyrazinamide
rpsA	1834468	c.927A>G	synonymous_variant	0.56	pyrazinamide
rpsA	1834489	c.948T>C	synonymous_variant	0.5	pyrazinamide
rpsA	1834513	c.972C>G	synonymous_variant	0.36	pyrazinamide
rpsA	1834528	c.987T>C	synonymous_variant	0.42	pyrazinamide
rpsA	1834540	c.999G>C	synonymous_variant	0.4	pyrazinamide
rpsA	1834546	c.1005T>C	synonymous_variant	0.4	pyrazinamide
rpsA	1834555	c.1014T>G	synonymous_variant	0.32	pyrazinamide
rpsA	1834633	c.1092A>G	synonymous_variant	0.3	pyrazinamide
rpsA	1834654	p.Glu371Asp	missense_variant	0.29	pyrazinamide
rpsA	1834690	c.1149T>C	synonymous_variant	0.26	pyrazinamide
tsnR	1854300	p.Leu232Pro	missense_variant	1.0	linezolid	Not assoc w R
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
bacA	2064912	c.-184A>G	upstream_gene_variant	0.41	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064915	c.-187G>C	upstream_gene_variant	0.32	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064933	c.-205A>G	upstream_gene_variant	0.42	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064936	c.-208C>G	upstream_gene_variant	0.42	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064942	c.-214G>A	upstream_gene_variant	0.42	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064948	c.-220G>C	upstream_gene_variant	0.42	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064972	c.-244T>C	upstream_gene_variant	0.42	streptomycin
					kanamycin
					capreomycin
					amikacin
bacA	2064984	c.-256A>G	upstream_gene_variant	0.44	streptomycin
					kanamycin
					capreomycin
					amikacin
ndh	2101804	c.1239T>G	synonymous_variant	0.35	ethionamide
					delamanid
					isoniazid
ndh	2101808	p.Thr412Ser	missense_variant	0.35	ethionamide
					delamanid
					isoniazid
ndh	2101830	p.Ile405Val	missense_variant	0.45	ethionamide
					delamanid
					isoniazid
ndh	2101837	p.Ala402Val	missense_variant	0.45	ethionamide	Uncertain significance
					delamanid
					isoniazid	Uncertain significance
ndh	2101872	p.Ile391Phe	missense_variant	0.46	ethionamide
					delamanid
					isoniazid
ndh	2101873	c.1168_1170delTTTinsCA	frameshift_variant&missense_variant	0.46	ethionamide	Uncertain significance
					delamanid	Uncertain significance
					isoniazid	Uncertain significance
ndh	2101885	c.1158G>A	synonymous_variant	0.46	ethionamide
					delamanid
					isoniazid
ndh	2101888	c.1155T>C	synonymous_variant	0.52	ethionamide
					delamanid
					isoniazid
ndh	2101894	c.1149T>G	synonymous_variant	0.52	ethionamide
					delamanid
					isoniazid
ndh	2101912	c.1131G>C	synonymous_variant	0.57	ethionamide
					delamanid
					isoniazid
ndh	2101920	c.1123A>C	synonymous_variant	0.57	ethionamide
					delamanid
					isoniazid
ndh	2101924	c.1119T>G	synonymous_variant	0.57	ethionamide
					delamanid
					isoniazid
ndh	2101939	c.1104A>G	synonymous_variant	0.68	ethionamide
					delamanid
					isoniazid
ndh	2101960	c.1083A>G	synonymous_variant	0.44	ethionamide
					delamanid
					isoniazid
ndh	2101963	c.1080G>A	synonymous_variant	0.4	ethionamide	Not assoc w R - Interim
					delamanid	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
ndh	2101966	c.1077T>G	synonymous_variant	0.4	ethionamide
					delamanid
					isoniazid
kasA	2517950	c.-165C>G	upstream_gene_variant	0.48	isoniazid
kasA	2517989	c.-126T>C	upstream_gene_variant	0.5	isoniazid
kasA	2517993	c.-122G>T	upstream_gene_variant	0.46	isoniazid
kasA	2518019	c.-96A>G	upstream_gene_variant	0.45	isoniazid
kasA	2518025	c.-90G>C	upstream_gene_variant	0.44	isoniazid
kasA	2518031	c.-84G>C	upstream_gene_variant	0.41	isoniazid
kasA	2518034	c.-81T>C	upstream_gene_variant	0.39	isoniazid
kasA	2518035	c.-80C>G	upstream_gene_variant	0.39	isoniazid
kasA	2518041	c.-74T>C	upstream_gene_variant	0.44	isoniazid
kasA	2518049	c.-66G>C	upstream_gene_variant	0.47	isoniazid
kasA	2518053	c.-62_-60delATTinsCG	upstream_gene_variant	0.41	isoniazid
kasA	2518059	c.-56_-54delTCGinsAC	upstream_gene_variant	0.41	isoniazid
kasA	2518073	c.-42T>C	upstream_gene_variant	0.44	isoniazid
kasA	2518076	c.-39C>G	upstream_gene_variant	0.44	isoniazid
kasA	2518079	c.-36T>C	upstream_gene_variant	0.44	isoniazid
kasA	2518088	c.-27T>C	upstream_gene_variant	0.44	isoniazid
kasA	2518089	c.-26C>A	upstream_gene_variant	0.44	isoniazid
kasA	2518094	c.-21G>A	upstream_gene_variant	0.44	isoniazid
kasA	2518100	c.-15T>G	upstream_gene_variant	0.44	isoniazid
kasA	2518103	c.-12G>A	upstream_gene_variant	0.44	isoniazid
kasA	2518106	c.-9C>G	upstream_gene_variant	0.44	isoniazid
kasA	2518109	c.-6G>C	upstream_gene_variant	0.44	isoniazid
kasA	2518110	c.-5T>A	upstream_gene_variant	0.44	isoniazid
kasA	2518121	p.Gln3Lys	missense_variant	0.44	isoniazid
kasA	2518132	c.18C>T	synonymous_variant	1.0	isoniazid
kasA	2519062	c.948T>G	synonymous_variant	0.58	isoniazid
kasA	2519068	c.954C>T	synonymous_variant	0.62	isoniazid
kasA	2519072	p.Ala320Thr	missense_variant	0.62	isoniazid
kasA	2519107	c.993T>C	synonymous_variant	0.7	isoniazid
kasA	2519108	c.994_996delGATinsCG	frameshift_variant&missense_variant	0.7	isoniazid
kasA	2519116	c.1002C>G	synonymous_variant	0.7	isoniazid
kasA	2519122	c.1008G>C	synonymous_variant	0.7	isoniazid
kasA	2519167	c.1053T>G	synonymous_variant	0.7	isoniazid
ahpC	2726051	c.-142G>A	upstream_gene_variant	1.0	isoniazid
ahpC	2726528	c.336C>G	synonymous_variant	0.32	isoniazid
folC	2747335	c.264G>C	synonymous_variant	0.5	para-aminosalicylic_acid
folC	2747430	c.169C>T	synonymous_variant	0.43	para-aminosalicylic_acid
folC	2747442	c.157T>C	synonymous_variant	0.38	para-aminosalicylic_acid
folC	2747467	p.Asp44Glu	missense_variant	0.38	para-aminosalicylic_acid
folC	2747473	p.Arg42Lys	missense_variant	0.35	para-aminosalicylic_acid
folC	2747479	c.120G>A	synonymous_variant	0.35	para-aminosalicylic_acid
folC	2747482	c.117G>C	synonymous_variant	0.35	para-aminosalicylic_acid
folC	2747491	c.108A>G	synonymous_variant	0.32	para-aminosalicylic_acid
folC	2747497	c.102C>G	synonymous_variant	0.32	para-aminosalicylic_acid
folC	2747503	c.96T>C	synonymous_variant	0.32	para-aminosalicylic_acid
folC	2747509	c.90T>C	synonymous_variant	0.33	para-aminosalicylic_acid
folC	2747517	c.82C>T	synonymous_variant	0.35	para-aminosalicylic_acid
Rv2477c	2782981	c.1062G>C	synonymous_variant	0.4	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782984	c.1059T>C	synonymous_variant	0.4	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2782990	c.1053C>G	synonymous_variant	0.5	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783002	c.1041T>C	synonymous_variant	0.45	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783008	c.1035C>G	synonymous_variant	0.45	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783013	c.1030T>C	synonymous_variant	0.47	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783015	p.Ser343Thr	missense_variant	0.47	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783035	c.1008G>C	synonymous_variant	0.5	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783040	p.Ala335Thr	missense_variant	0.5	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					kanamycin	Uncertain significance
					rifampicin	Uncertain significance
					amikacin	Uncertain significance
Rv2477c	2783044	c.999G>C	synonymous_variant	0.5	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783048	p.Asp332Gly	missense_variant	0.45	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783059	c.984T>C	synonymous_variant	0.43	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783068	p.Asp325Glu	missense_variant	0.4	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783077	c.966T>C	synonymous_variant	0.4	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783092	c.951A>G	synonymous_variant	0.42	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin	Not assoc w R - Interim
					amikacin
Rv2477c	2783095	c.948C>G	synonymous_variant	0.42	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R
					amikacin	Not assoc w R - Interim
Rv2477c	2783098	c.945C>G	synonymous_variant	0.42	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783101	c.942G>T	synonymous_variant	0.38	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783116	c.927T>C	synonymous_variant	0.56	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783140	c.903C>G	synonymous_variant	0.67	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783146	c.897G>A	synonymous_variant	0.59	ethambutol
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin
					amikacin	Not assoc w R - Interim
Rv2477c	2783149	c.894G>C	synonymous_variant	0.59	ethambutol
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783158	c.885A>C	synonymous_variant	0.53	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					amikacin	Not assoc w R - Interim
Rv2477c	2783179	c.864G>C	synonymous_variant	0.41	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783182	c.861C>G	synonymous_variant	0.41	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783185	c.858G>A	synonymous_variant	0.41	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783194	c.849A>G	synonymous_variant	0.44	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783209	c.834G>A	synonymous_variant	0.5	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783221	c.822G>C	synonymous_variant	0.56	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783224	c.819C>G	synonymous_variant	0.64	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783230	c.813T>G	synonymous_variant	0.64	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					kanamycin
					rifampicin	Not assoc w R - Interim
					amikacin
Rv2477c	2783235	c.808T>C	synonymous_variant	0.56	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783254	c.789A>G	synonymous_variant	0.5	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783263	c.780G>C	synonymous_variant	0.47	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783275	c.768C>G	synonymous_variant	0.44	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783278	c.765A>G	synonymous_variant	0.44	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783620	c.423C>G	synonymous_variant	0.47	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783628	p.Ala139Ser	missense_variant	0.47	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783656	c.387G>C	synonymous_variant	0.5	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783665	c.378A>G	synonymous_variant	0.5	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783674	c.369T>C	synonymous_variant	0.5	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783683	c.360A>G	synonymous_variant	0.44	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783700	p.Thr115Ser	missense_variant	0.47	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2752c	3065979	c.213T>C	synonymous_variant	0.43	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3065993	p.Val67Ile	missense_variant	0.5	ethambutol	Uncertain significance
					moxifloxacin
					levofloxacin
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
Rv2752c	3065994	c.198T>C	synonymous_variant	0.6	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066002	p.Met64Leu	missense_variant	0.55	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066009	c.183G>C	synonymous_variant	0.55	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066018	c.174T>C	synonymous_variant	0.63	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066024	c.168T>G	synonymous_variant	0.63	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066040	p.Gly51Thr	missense_variant	0.53	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066042	c.150T>C	synonymous_variant	0.53	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066045	c.147T>C	synonymous_variant	0.53	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066050	p.Leu48Met	missense_variant	0.56	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066054	c.138T>G	synonymous_variant	0.56	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066066	c.126T>C	synonymous_variant	0.56	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066074	c.118C>T	synonymous_variant	0.53	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066075	c.117A>G	synonymous_variant	0.53	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066078	c.114C>T	synonymous_variant	0.53	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066102	c.90C>T	synonymous_variant	0.53	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066118	p.Asn25Ser	missense_variant	0.58	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066330	c.-139G>C	upstream_gene_variant	0.38	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066335	c.-144T>C	upstream_gene_variant	0.35	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066339	c.-148G>C	upstream_gene_variant	0.32	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066360	c.-169T>C	upstream_gene_variant	0.36	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066369	c.-180_-178delAGCinsGCG	upstream_gene_variant	0.36	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066380	c.-189A>G	upstream_gene_variant	0.36	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066432	c.-241T>C	upstream_gene_variant	0.3	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066435	c.-246_-244delGGTinsAAC	upstream_gene_variant	0.33	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066452	c.-261T>A	upstream_gene_variant	0.33	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066453	c.-262G>A	upstream_gene_variant	0.33	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066456	c.-265A>G	upstream_gene_variant	0.33	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066462	c.-271G>A	upstream_gene_variant	0.37	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066465	c.-276_-274delGGGinsAAT	upstream_gene_variant	0.37	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066471	c.-280A>G	upstream_gene_variant	0.37	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066476	c.-285C>G	upstream_gene_variant	0.37	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066482	c.-291G>T	upstream_gene_variant	0.41	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066483	c.-292T>C	upstream_gene_variant	0.41	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066501	c.-310G>C	upstream_gene_variant	0.47	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066522	c.-331C>G	upstream_gene_variant	0.53	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066531	c.-340C>G	upstream_gene_variant	0.5	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
Rv2752c	3066549	c.-358T>C	upstream_gene_variant	0.53	ethambutol
					moxifloxacin
					levofloxacin
					rifampicin
					isoniazid
thyX	3067490	c.456C>G	synonymous_variant	0.4	para-aminosalicylic_acid
thyX	3067493	c.453A>G	synonymous_variant	0.4	para-aminosalicylic_acid
thyX	3067515	p.Ser144Thr	missense_variant	0.32	para-aminosalicylic_acid
thyX	3067530	p.Ala139Ser	missense_variant	0.32	para-aminosalicylic_acid
thyX	3067545	p.Glu134Ala	missense_variant	0.44	para-aminosalicylic_acid
thyX	3067549	p.Thr133Ala	missense_variant	0.41	para-aminosalicylic_acid
thyX	3067556	p.His130Gln	missense_variant	0.41	para-aminosalicylic_acid
thyX	3067559	c.387C>G	synonymous_variant	0.39	para-aminosalicylic_acid
thyX	3067565	p.Asp127Glu	missense_variant	0.39	para-aminosalicylic_acid
thyX	3067570	p.Ala126Pro	missense_variant	0.39	para-aminosalicylic_acid
thyX	3067577	c.369G>A	synonymous_variant	0.37	para-aminosalicylic_acid
thyX	3067583	c.363C>G	synonymous_variant	0.35	para-aminosalicylic_acid
thyA	3073836	c.636C>T	synonymous_variant	0.31	para-aminosalicylic_acid
thyA	3073839	c.633T>C	synonymous_variant	0.31	para-aminosalicylic_acid
thyA	3073860	c.612C>G	synonymous_variant	0.31	para-aminosalicylic_acid
thyA	3073863	c.609T>C	synonymous_variant	0.31	para-aminosalicylic_acid
thyA	3073866	c.606C>G	synonymous_variant	0.31	para-aminosalicylic_acid
thyA	3073872	c.598_600delATCinsGG	frameshift_variant&missense_variant	0.31	para-aminosalicylic_acid
thyA	3073892	c.580T>C	synonymous_variant	0.29	para-aminosalicylic_acid
thyA	3073898	p.Ala192Ser	missense_variant	0.28	para-aminosalicylic_acid
thyA	3074205	p.Glu89Asp	missense_variant	0.3	para-aminosalicylic_acid
thyA	3074214	c.258T>C	synonymous_variant	0.29	para-aminosalicylic_acid
ald	3086788	c.-32T>C	upstream_gene_variant	1.0	cycloserine
Rv3083	3448714	p.Asp71His	missense_variant	1.0	ethionamide	Uncertain significance
whiB7	3568488	c.191delG	frameshift_variant	1.0	streptomycin	Uncertain significance
					amikacin	Uncertain significance
					kanamycin	Uncertain significance
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624704	c.207G>C	synonymous_variant	0.39	bedaquiline
lpqB	3624704	c.207G>C	synonymous_variant	0.39	rifampicin
lpqB	3624707	c.204G>C	synonymous_variant	0.39	bedaquiline
lpqB	3624707	c.204G>C	synonymous_variant	0.39	rifampicin
lpqB	3624722	c.189C>G	synonymous_variant	0.45	bedaquiline	Not assoc w R - Interim
lpqB	3624722	c.189C>G	synonymous_variant	0.45	rifampicin	Not assoc w R - Interim
lpqB	3624728	c.183C>T	synonymous_variant	0.45	bedaquiline
lpqB	3624728	c.183C>T	synonymous_variant	0.45	rifampicin
lpqB	3624749	c.162G>A	synonymous_variant	0.33	bedaquiline
lpqB	3624749	c.162G>A	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
lpqB	3624755	c.154_156delTTAinsCG	frameshift_variant&missense_variant	0.4	bedaquiline
lpqB	3624755	c.154_156delTTAinsCG	frameshift_variant&missense_variant	0.4	rifampicin	Uncertain significance
lpqB	3624770	c.141T>C	synonymous_variant	0.4	bedaquiline
lpqB	3624770	c.141T>C	synonymous_variant	0.4	rifampicin
lpqB	3624776	c.135T>C	synonymous_variant	0.4	bedaquiline
lpqB	3624776	c.135T>C	synonymous_variant	0.4	rifampicin
lpqB	3624783	p.Ser43Thr	missense_variant	0.4	bedaquiline
lpqB	3624783	p.Ser43Thr	missense_variant	0.4	rifampicin
lpqB	3624788	c.123A>G	synonymous_variant	0.43	bedaquiline	Not assoc w R - Interim
lpqB	3624788	c.123A>G	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
lpqB	3624797	c.114T>C	synonymous_variant	0.5	bedaquiline
lpqB	3624797	c.114T>C	synonymous_variant	0.5	rifampicin
lpqB	3624807	p.Val35Ala	missense_variant	0.43	bedaquiline
lpqB	3624807	p.Val35Ala	missense_variant	0.43	rifampicin
lpqB	3624812	c.99T>G	synonymous_variant	0.43	bedaquiline
lpqB	3624812	c.99T>G	synonymous_variant	0.43	rifampicin
lpqB	3624815	c.96A>G	synonymous_variant	0.43	bedaquiline
lpqB	3624815	c.96A>G	synonymous_variant	0.43	rifampicin
mtrB	3625497	c.1117T>C	synonymous_variant	0.47	bedaquiline
mtrB	3625497	c.1117T>C	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
lpqB	3625510	c.-600T>C	upstream_gene_variant	0.47	bedaquiline
lpqB	3625510	c.-600T>C	upstream_gene_variant	0.47	rifampicin
lpqB	3625513	c.-603G>C	upstream_gene_variant	0.47	bedaquiline
lpqB	3625513	c.-603G>C	upstream_gene_variant	0.47	rifampicin
lpqB	3625518	c.-608T>C	upstream_gene_variant	0.47	bedaquiline
lpqB	3625518	c.-608T>C	upstream_gene_variant	0.47	rifampicin
lpqB	3625525	c.-615G>C	upstream_gene_variant	0.54	bedaquiline
lpqB	3625525	c.-615G>C	upstream_gene_variant	0.54	rifampicin
lpqB	3625528	c.-618G>T	upstream_gene_variant	0.54	bedaquiline
lpqB	3625528	c.-618G>T	upstream_gene_variant	0.54	rifampicin
lpqB	3625537	c.-627T>C	upstream_gene_variant	0.54	bedaquiline
lpqB	3625537	c.-627T>C	upstream_gene_variant	0.54	rifampicin
lpqB	3625543	c.-633G>C	upstream_gene_variant	0.54	bedaquiline
lpqB	3625543	c.-633G>C	upstream_gene_variant	0.54	rifampicin
lpqB	3625549	c.-639G>A	upstream_gene_variant	0.47	bedaquiline
lpqB	3625549	c.-639G>A	upstream_gene_variant	0.47	rifampicin
mtrB	3625569	c.1045T>C	synonymous_variant	0.5	bedaquiline
mtrB	3625569	c.1045T>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
mtrB	3625572	p.Thr348Ser	missense_variant	0.5	bedaquiline
mtrB	3625572	p.Thr348Ser	missense_variant	0.5	rifampicin
lpqB	3625579	c.-669A>G	upstream_gene_variant	0.53	bedaquiline
lpqB	3625579	c.-669A>G	upstream_gene_variant	0.53	rifampicin
lpqB	3625594	c.-684T>C	upstream_gene_variant	0.64	bedaquiline
lpqB	3625594	c.-684T>C	upstream_gene_variant	0.64	rifampicin
lpqB	3625602	c.-692T>C	upstream_gene_variant	0.64	bedaquiline
lpqB	3625602	c.-692T>C	upstream_gene_variant	0.64	rifampicin
lpqB	3625612	c.-702G>C	upstream_gene_variant	0.56	bedaquiline
lpqB	3625612	c.-702G>C	upstream_gene_variant	0.56	rifampicin
mtrB	3625616	p.Arg333Ala	missense_variant	0.56	bedaquiline
mtrB	3625616	p.Arg333Ala	missense_variant	0.56	rifampicin
lpqB	3625624	c.-714C>G	upstream_gene_variant	0.56	bedaquiline
lpqB	3625624	c.-714C>G	upstream_gene_variant	0.56	rifampicin
mtrB	3625636	c.978C>G	synonymous_variant	0.56	bedaquiline
mtrB	3625636	c.978C>G	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
mtrB	3625656	c.958T>C	synonymous_variant	0.53	bedaquiline	Not assoc w R - Interim
mtrB	3625656	c.958T>C	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
lpqB	3625663	c.-753G>C	upstream_gene_variant	0.53	bedaquiline
lpqB	3625663	c.-753G>C	upstream_gene_variant	0.53	rifampicin
lpqB	3625669	c.-759G>C	upstream_gene_variant	0.56	bedaquiline
lpqB	3625669	c.-759G>C	upstream_gene_variant	0.56	rifampicin
lpqB	3625687	c.-777G>C	upstream_gene_variant	0.44	bedaquiline
lpqB	3625687	c.-777G>C	upstream_gene_variant	0.44	rifampicin
lpqB	3625690	c.-780T>C	upstream_gene_variant	0.44	bedaquiline
lpqB	3625690	c.-780T>C	upstream_gene_variant	0.44	rifampicin
lpqB	3625696	c.-786A>G	upstream_gene_variant	0.45	bedaquiline
lpqB	3625696	c.-786A>G	upstream_gene_variant	0.45	rifampicin
mtrB	3625705	c.909C>G	synonymous_variant	0.44	bedaquiline
mtrB	3625705	c.909C>G	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
lpqB	3625714	c.-804C>T	upstream_gene_variant	0.44	bedaquiline
lpqB	3625714	c.-804C>T	upstream_gene_variant	0.44	rifampicin
mtrB	3625720	c.894G>C	synonymous_variant	0.44	bedaquiline
mtrB	3625720	c.894G>C	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
mtrB	3625729	c.885A>G	synonymous_variant	0.41	bedaquiline
mtrB	3625729	c.885A>G	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
lpqB	3625735	c.-825C>T	upstream_gene_variant	0.41	bedaquiline
lpqB	3625735	c.-825C>T	upstream_gene_variant	0.41	rifampicin
lpqB	3625749	c.-839C>T	upstream_gene_variant	0.41	bedaquiline
lpqB	3625749	c.-839C>T	upstream_gene_variant	0.41	rifampicin
mtrB	3625750	c.864G>A	synonymous_variant	0.41	bedaquiline
mtrB	3625750	c.864G>A	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
mtrB	3625755	p.Ala287Thr	missense_variant	0.41	bedaquiline
mtrB	3625755	p.Ala287Thr	missense_variant	0.41	rifampicin	Uncertain significance
mtrB	3625765	c.849C>G	synonymous_variant	0.5	bedaquiline
mtrB	3625765	c.849C>G	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
mtrB	3625774	c.840G>A	synonymous_variant	0.5	bedaquiline
mtrB	3625774	c.840G>A	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
mtrB	3625797	p.Val273Met	missense_variant	0.57	bedaquiline	Uncertain significance
mtrB	3625797	p.Val273Met	missense_variant	0.57	rifampicin	Uncertain significance
mtrB	3625806	c.808A>C	synonymous_variant	0.63	bedaquiline
mtrB	3625806	c.808A>C	synonymous_variant	0.63	rifampicin	Not assoc w R - Interim
mtrB	3625807	c.807C>G	synonymous_variant	0.57	bedaquiline
mtrB	3625807	c.807C>G	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
mtrB	3625837	c.777C>G	synonymous_variant	0.53	bedaquiline
mtrB	3625837	c.777C>G	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
lpqB	3625849	c.-939T>C	upstream_gene_variant	0.42	bedaquiline
lpqB	3625849	c.-939T>C	upstream_gene_variant	0.42	rifampicin
mtrB	3625852	c.762A>G	synonymous_variant	0.42	bedaquiline
mtrB	3625852	c.762A>G	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
lpqB	3625864	c.-954T>G	upstream_gene_variant	0.37	bedaquiline
lpqB	3625864	c.-954T>G	upstream_gene_variant	0.37	rifampicin
mtrB	3626101	p.Gln171His	missense_variant	0.24	bedaquiline
mtrB	3626101	p.Gln171His	missense_variant	0.24	rifampicin
mtrB	3626110	c.504C>G	synonymous_variant	0.29	bedaquiline
mtrB	3626110	c.504C>G	synonymous_variant	0.29	rifampicin
mtrB	3626124	p.Ala164Ser	missense_variant	0.35	bedaquiline
mtrB	3626124	p.Ala164Ser	missense_variant	0.35	rifampicin
mtrB	3626125	c.489C>G	synonymous_variant	0.35	bedaquiline
mtrB	3626125	c.489C>G	synonymous_variant	0.35	rifampicin
mtrB	3626155	c.457_459delGCGinsTC	frameshift_variant&missense_variant	0.37	bedaquiline	Uncertain significance
mtrB	3626155	c.457_459delGCGinsTC	frameshift_variant&missense_variant	0.37	rifampicin	Uncertain significance
mtrB	3626158	c.456C>T	synonymous_variant	0.35	bedaquiline
mtrB	3626158	c.456C>T	synonymous_variant	0.35	rifampicin
mtrB	3626161	c.453C>A	synonymous_variant	0.35	bedaquiline
mtrB	3626161	c.453C>A	synonymous_variant	0.35	rifampicin
mtrB	3626170	c.444T>C	synonymous_variant	0.35	bedaquiline
mtrB	3626170	c.444T>C	synonymous_variant	0.35	rifampicin
mtrB	3626179	c.435A>T	synonymous_variant	0.39	bedaquiline
mtrB	3626179	c.435A>T	synonymous_variant	0.39	rifampicin
mtrB	3626185	c.429T>G	synonymous_variant	0.39	bedaquiline
mtrB	3626185	c.429T>G	synonymous_variant	0.39	rifampicin	Not assoc w R - Interim
mtrB	3626188	c.424_426delTCTinsAC	frameshift_variant&missense_variant	0.39	bedaquiline	Uncertain significance
mtrB	3626188	c.424_426delTCTinsAC	frameshift_variant&missense_variant	0.39	rifampicin	Uncertain significance
mtrB	3626191	c.423C>G	synonymous_variant	0.39	bedaquiline
mtrB	3626191	c.423C>G	synonymous_variant	0.39	rifampicin
mtrB	3626194	c.420T>C	synonymous_variant	0.44	bedaquiline
mtrB	3626194	c.420T>C	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
mtrB	3626203	c.411G>A	synonymous_variant	0.44	bedaquiline
mtrB	3626203	c.411G>A	synonymous_variant	0.44	rifampicin
mtrB	3626206	c.408T>C	synonymous_variant	0.44	bedaquiline	Not assoc w R - Interim
mtrB	3626206	c.408T>C	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
mtrB	3626209	c.405T>C	synonymous_variant	0.44	bedaquiline	Not assoc w R - Interim
mtrB	3626209	c.405T>C	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
mtrA	3626759	c.591T>C	synonymous_variant	0.53	bedaquiline
mtrA	3626759	c.591T>C	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
mtrA	3626774	c.574_576delAGGinsCC	frameshift_variant&missense_variant	0.57	bedaquiline
mtrA	3626774	c.574_576delAGGinsCC	frameshift_variant&missense_variant	0.57	rifampicin
mtrB	3626783	c.-170C>G	upstream_gene_variant	0.54	bedaquiline
mtrB	3626783	c.-170C>G	upstream_gene_variant	0.54	rifampicin
mtrA	3626786	c.564A>G	synonymous_variant	0.57	bedaquiline
mtrA	3626786	c.564A>G	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
mtrA	3626792	c.558G>T	synonymous_variant	0.57	bedaquiline
mtrA	3626792	c.558G>T	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
mtrB	3626795	c.-182C>T	upstream_gene_variant	0.57	bedaquiline
mtrB	3626795	c.-182C>T	upstream_gene_variant	0.57	rifampicin
mtrB	3626798	c.-185T>C	upstream_gene_variant	0.6	bedaquiline
mtrB	3626798	c.-185T>C	upstream_gene_variant	0.6	rifampicin
mtrA	3626804	c.546A>G	synonymous_variant	0.58	bedaquiline
mtrA	3626804	c.546A>G	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
mtrB	3626840	c.-227C>G	upstream_gene_variant	0.65	bedaquiline
mtrB	3626840	c.-227C>G	upstream_gene_variant	0.65	rifampicin
mtrA	3626846	c.504G>A	synonymous_variant	0.65	bedaquiline
mtrA	3626846	c.504G>A	synonymous_variant	0.65	rifampicin	Not assoc w R - Interim
mtrB	3626858	c.-245A>G	upstream_gene_variant	0.62	bedaquiline
mtrB	3626858	c.-245A>G	upstream_gene_variant	0.62	rifampicin
mtrB	3626861	c.-248C>G	upstream_gene_variant	0.62	bedaquiline
mtrB	3626861	c.-248C>G	upstream_gene_variant	0.62	rifampicin
mtrB	3626866	c.-253T>C	upstream_gene_variant	0.62	bedaquiline
mtrB	3626866	c.-253T>C	upstream_gene_variant	0.62	rifampicin
mtrB	3626876	c.-263A>G	upstream_gene_variant	0.58	bedaquiline
mtrB	3626876	c.-263A>G	upstream_gene_variant	0.58	rifampicin
mtrB	3626885	c.-272A>C	upstream_gene_variant	0.45	bedaquiline
mtrB	3626885	c.-272A>C	upstream_gene_variant	0.45	rifampicin
mtrB	3626890	c.-277T>C	upstream_gene_variant	0.45	bedaquiline
mtrB	3626890	c.-277T>C	upstream_gene_variant	0.45	rifampicin
mtrB	3626903	c.-290T>C	upstream_gene_variant	0.42	bedaquiline
mtrB	3626903	c.-290T>C	upstream_gene_variant	0.42	rifampicin
mtrB	3626912	c.-299T>G	upstream_gene_variant	0.5	bedaquiline
mtrB	3626912	c.-299T>G	upstream_gene_variant	0.5	rifampicin
mtrB	3626927	c.-314G>C	upstream_gene_variant	0.46	bedaquiline
mtrB	3626927	c.-314G>C	upstream_gene_variant	0.46	rifampicin
mtrB	3626930	c.-317A>G	upstream_gene_variant	0.46	bedaquiline
mtrB	3626930	c.-317A>G	upstream_gene_variant	0.46	rifampicin
mtrA	3626939	c.411A>G	synonymous_variant	0.46	bedaquiline
mtrA	3626939	c.411A>G	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
mtrB	3626942	c.-329A>C	upstream_gene_variant	0.46	bedaquiline
mtrB	3626942	c.-329A>C	upstream_gene_variant	0.46	rifampicin
mtrB	3626957	c.-344G>C	upstream_gene_variant	0.46	bedaquiline
mtrB	3626957	c.-344G>C	upstream_gene_variant	0.46	rifampicin
mtrB	3626972	c.-359A>G	upstream_gene_variant	0.52	bedaquiline
mtrB	3626972	c.-359A>G	upstream_gene_variant	0.52	rifampicin
mtrB	3626987	c.-374C>G	upstream_gene_variant	0.5	bedaquiline
mtrB	3626987	c.-374C>G	upstream_gene_variant	0.5	rifampicin
mtrB	3627008	c.-395G>C	upstream_gene_variant	0.56	bedaquiline
mtrB	3627008	c.-395G>C	upstream_gene_variant	0.56	rifampicin
mtrB	3627011	c.-398T>G	upstream_gene_variant	0.53	bedaquiline
mtrB	3627011	c.-398T>G	upstream_gene_variant	0.53	rifampicin
mtrB	3627065	c.-452G>C	upstream_gene_variant	0.47	bedaquiline
mtrB	3627065	c.-452G>C	upstream_gene_variant	0.47	rifampicin
mtrA	3627068	c.282T>C	synonymous_variant	0.41	bedaquiline
mtrA	3627068	c.282T>C	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
mtrA	3627071	c.279G>T	synonymous_variant	0.47	bedaquiline
mtrA	3627071	c.279G>T	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
mtrB	3627074	c.-461G>C	upstream_gene_variant	0.47	bedaquiline
mtrB	3627074	c.-461G>C	upstream_gene_variant	0.47	rifampicin
mtrA	3627080	c.270T>C	synonymous_variant	0.41	bedaquiline
mtrA	3627080	c.270T>C	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
mtrB	3627083	c.-470G>C	upstream_gene_variant	0.41	bedaquiline
mtrB	3627083	c.-470G>C	upstream_gene_variant	0.41	rifampicin
mtrA	3627098	c.252A>C	synonymous_variant	0.35	bedaquiline
mtrA	3627098	c.252A>C	synonymous_variant	0.35	rifampicin	Not assoc w R - Interim
mtrB	3627104	c.-491C>G	upstream_gene_variant	0.35	bedaquiline
mtrB	3627104	c.-491C>G	upstream_gene_variant	0.35	rifampicin
mtrA	3627119	c.231T>G	synonymous_variant	0.41	bedaquiline
mtrA	3627119	c.231T>G	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
mtrB	3627122	c.-509T>C	upstream_gene_variant	0.41	bedaquiline
mtrB	3627122	c.-509T>C	upstream_gene_variant	0.41	rifampicin
mtrB	3627167	c.-554T>C	upstream_gene_variant	0.39	bedaquiline
mtrB	3627167	c.-554T>C	upstream_gene_variant	0.39	rifampicin
mtrB	3627181	c.-568T>C	upstream_gene_variant	0.38	bedaquiline
mtrB	3627181	c.-568T>C	upstream_gene_variant	0.38	rifampicin
mtrB	3627182	c.-569T>C	upstream_gene_variant	0.38	bedaquiline
mtrB	3627182	c.-569T>C	upstream_gene_variant	0.38	rifampicin
mtrA	3627188	c.162A>G	synonymous_variant	0.38	bedaquiline
mtrA	3627188	c.162A>G	synonymous_variant	0.38	rifampicin	Not assoc w R - Interim
mtrB	3627209	c.-596G>A	upstream_gene_variant	0.44	bedaquiline
mtrB	3627209	c.-596G>A	upstream_gene_variant	0.44	rifampicin
mtrA	3627221	c.129C>T	synonymous_variant	0.47	bedaquiline
mtrA	3627221	c.129C>T	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
mtrA	3627227	c.123T>C	synonymous_variant	0.44	bedaquiline
mtrA	3627227	c.123T>C	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
fbiA	3640230	c.-313T>G	upstream_gene_variant	1.0	clofazimine
					pretomanid
					delamanid
rpoA	3877553	p.Glu319Gln	missense_variant	0.26	rifampicin
rpoA	3877571	p.Pro313Ala	missense_variant	0.28	rifampicin
rpoA	3877587	c.921A>G	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoA	3877613	p.Ile299Val	missense_variant	0.39	rifampicin
rpoA	3877656	c.852T>G	synonymous_variant	0.56	rifampicin	Not assoc w R - Interim
rpoA	3877668	c.840A>G	synonymous_variant	0.52	rifampicin
rpoA	3877679	p.Ala277Ser	missense_variant	0.48	rifampicin
rpoA	3877686	c.822A>G	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
rpoA	3877692	c.816G>C	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
rpoA	3877704	c.804G>C	synonymous_variant	0.43	rifampicin
rpoA	3877743	c.765T>C	synonymous_variant	0.52	rifampicin	Not assoc w R - Interim
rpoA	3877764	c.744C>G	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoA	3877770	c.738A>G	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
rpoA	3877776	c.732T>C	synonymous_variant	0.36	rifampicin	Not assoc w R - Interim
rpoA	3877782	c.726T>C	synonymous_variant	0.39	rifampicin	Not assoc w R - Interim
rpoA	3877791	c.717C>G	synonymous_variant	0.39	rifampicin
rpoA	3877818	c.690A>G	synonymous_variant	0.38	rifampicin	Not assoc w R - Interim
rpoA	3877839	c.669G>C	synonymous_variant	0.42	rifampicin	Not assoc w R - Interim
rpoA	3877848	c.660C>T	synonymous_variant	0.44	rifampicin	Not assoc w R - Interim
rpoA	3877857	c.651G>A	synonymous_variant	0.57	rifampicin
rpoA	3877866	c.642G>C	synonymous_variant	0.57	rifampicin
rpoA	3877875	c.633T>G	synonymous_variant	0.57	rifampicin
rpoA	3877878	c.630G>C	synonymous_variant	0.57	rifampicin
rpoA	3877890	c.618C>T	synonymous_variant	0.57	rifampicin
rpoA	3877896	c.612G>C	synonymous_variant	0.57	rifampicin
rpoA	3877900	p.Ser203Asn	missense_variant	0.57	rifampicin
rpoA	3877905	c.603A>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoA	3877909	p.Asn200Ser	missense_variant	0.62	rifampicin
rpoA	3877920	c.588G>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoA	3877923	c.585C>T	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoA	3877926	c.582G>C	synonymous_variant	0.62	rifampicin
rpoA	3877962	c.546G>T	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoA	3878157	c.351C>G	synonymous_variant	0.33	rifampicin
rpoA	3878163	c.345C>T	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoA	3878169	c.339G>C	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoA	3878172	c.336G>C	synonymous_variant	0.33	rifampicin
rpoA	3878181	c.327C>T	synonymous_variant	0.33	rifampicin
rpoA	3878187	c.321C>G	synonymous_variant	0.33	rifampicin
rpoA	3878193	c.315T>C	synonymous_variant	0.41	rifampicin	Not assoc w R - Interim
rpoA	3878199	c.309T>C	synonymous_variant	0.38	rifampicin
rpoA	3878217	c.291A>G	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoA	3878226	c.282C>G	synonymous_variant	0.38	rifampicin
rpoA	3878232	c.276G>C	synonymous_variant	0.38	rifampicin
rpoA	3878247	c.261G>C	synonymous_variant	0.35	rifampicin
rpoA	3878271	c.237T>C	synonymous_variant	0.38	rifampicin	Not assoc w R - Interim
rpoA	3878284	p.Glu75Ala	missense_variant	0.33	rifampicin
rpoA	3878292	c.216T>C	synonymous_variant	0.31	rifampicin	Not assoc w R - Interim
rpoA	3878298	c.210A>G	synonymous_variant	0.3	rifampicin	Not assoc w R - Interim
rpoA	3878304	c.204G>C	synonymous_variant	0.26	rifampicin
rpoA	3878313	c.195G>C	synonymous_variant	0.26	rifampicin	Not assoc w R - Interim
rpoA	3878322	c.186A>G	synonymous_variant	0.33	rifampicin	Not assoc w R - Interim
rpoA	3878331	c.177A>G	synonymous_variant	0.27	rifampicin	Not assoc w R - Interim
rpoA	3878334	c.174T>C	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoA	3878337	c.171T>C	synonymous_variant	0.23	rifampicin	Not assoc w R - Interim
rpoA	3878340	c.168C>T	synonymous_variant	0.23	rifampicin
rpoA	3878346	c.162T>C	synonymous_variant	0.23	rifampicin
rpoA	3878364	c.144A>T	synonymous_variant	0.25	rifampicin
rpoA	3878367	c.141C>G	synonymous_variant	0.25	rifampicin
rpoA	3878376	c.132G>C	synonymous_variant	0.25	rifampicin
rpoA	3878385	c.123C>G	synonymous_variant	0.23	rifampicin
rpoA	3878388	c.120C>G	synonymous_variant	0.23	rifampicin
rpoA	3878391	c.117T>C	synonymous_variant	0.23	rifampicin
rpoA	3878415	c.93C>T	synonymous_variant	0.29	rifampicin
rpoA	3878424	c.84G>C	synonymous_variant	0.3	rifampicin
rpoA	3878947	c.-440G>C	upstream_gene_variant	0.58	rifampicin	Uncertain significance
rpoA	3878962	c.-455G>A	upstream_gene_variant	0.58	rifampicin	Uncertain significance
rpoA	3878968	c.-461T>C	upstream_gene_variant	0.5	rifampicin	Uncertain significance
rpoA	3878976	c.-469A>G	upstream_gene_variant	0.5	rifampicin	Uncertain significance
rpoA	3878986	c.-479G>C	upstream_gene_variant	0.58	rifampicin
rpoA	3878998	c.-491C>G	upstream_gene_variant	0.58	rifampicin	Uncertain significance
ddn	3986681	c.-163C>G	upstream_gene_variant	0.54	delamanid
ddn	3986681	c.-163C>G	upstream_gene_variant	0.54	pretomanid
ddn	3986690	c.-154C>G	upstream_gene_variant	0.54	delamanid
ddn	3986690	c.-154C>G	upstream_gene_variant	0.54	pretomanid
ddn	3986696	c.-148G>C	upstream_gene_variant	0.5	delamanid
ddn	3986696	c.-148G>C	upstream_gene_variant	0.5	pretomanid
clpC1	4038388	c.2317T>C	synonymous_variant	0.5	pyrazinamide
clpC1	4038392	c.2313C>T	synonymous_variant	0.5	pyrazinamide
clpC1	4038398	c.2307G>T	synonymous_variant	0.5	pyrazinamide
clpC1	4038403	c.2302T>C	synonymous_variant	0.5	pyrazinamide	Not assoc w R - Interim
clpC1	4038530	p.Glu725Asp	missense_variant	0.47	pyrazinamide
clpC1	4038596	c.2109A>G	synonymous_variant	0.67	pyrazinamide
clpC1	4038623	c.2082A>G	synonymous_variant	0.6	pyrazinamide
clpC1	4038640	p.Asp689Asn	missense_variant	0.53	pyrazinamide
clpC1	4038653	c.2052C>T	synonymous_variant	0.53	pyrazinamide
clpC1	4038658	p.Lys683Gln	missense_variant	0.53	pyrazinamide
clpC1	4038661	p.Ser682Thr	missense_variant	0.53	pyrazinamide
clpC1	4038662	c.2043T>C	synonymous_variant	0.53	pyrazinamide
clpC1	4038671	c.2034T>C	synonymous_variant	0.58	pyrazinamide
clpC1	4038683	c.2022T>C	synonymous_variant	0.57	pyrazinamide	Not assoc w R - Interim
clpC1	4038695	c.2010C>G	synonymous_variant	0.55	pyrazinamide
clpC1	4038701	c.2004G>C	synonymous_variant	0.55	pyrazinamide
clpC1	4038704	c.2001T>C	synonymous_variant	0.55	pyrazinamide
clpC1	4038707	c.1998C>G	synonymous_variant	0.57	pyrazinamide
clpC1	4038710	c.1995G>C	synonymous_variant	0.57	pyrazinamide
clpC1	4038713	c.1992T>C	synonymous_variant	0.61	pyrazinamide
clpC1	4038749	c.1956C>G	synonymous_variant	0.59	pyrazinamide
clpC1	4038755	c.1950G>T	synonymous_variant	0.6	pyrazinamide
clpC1	4038770	c.1935C>T	synonymous_variant	0.55	pyrazinamide
clpC1	4038773	c.1932T>C	synonymous_variant	0.55	pyrazinamide
clpC1	4038782	c.1923G>C	synonymous_variant	0.52	pyrazinamide
clpC1	4038812	c.1893T>C	synonymous_variant	0.53	pyrazinamide
clpC1	4038821	c.1884G>A	synonymous_variant	0.59	pyrazinamide
clpC1	4038845	c.1860G>C	synonymous_variant	0.54	pyrazinamide
clpC1	4038860	c.1845G>C	synonymous_variant	0.52	pyrazinamide	Not assoc w R - Interim
clpC1	4038878	c.1827A>G	synonymous_variant	0.5	pyrazinamide	Not assoc w R - Interim
clpC1	4038908	c.1797C>G	synonymous_variant	0.5	pyrazinamide
clpC1	4038914	c.1791G>C	synonymous_variant	0.5	pyrazinamide
clpC1	4038923	c.1780_1782delCTAinsTG	frameshift_variant&synonymous_variant	0.5	pyrazinamide
clpC1	4038953	c.1752A>G	synonymous_variant	0.56	pyrazinamide
clpC1	4038956	c.1749T>C	synonymous_variant	0.56	pyrazinamide
clpC1	4038965	c.1740T>C	synonymous_variant	0.56	pyrazinamide
clpC1	4038971	c.1734T>C	synonymous_variant	0.5	pyrazinamide
clpC1	4038974	c.1731T>C	synonymous_variant	0.5	pyrazinamide	Not assoc w R - Interim
clpC1	4038989	c.1716T>C	synonymous_variant	0.59	pyrazinamide
clpC1	4038997	c.1708T>C	synonymous_variant	0.55	pyrazinamide	Not assoc w R - Interim
clpC1	4039004	c.1701C>G	synonymous_variant	0.56	pyrazinamide
clpC1	4039022	c.1683A>G	synonymous_variant	0.55	pyrazinamide
clpC1	4039064	c.1641C>T	synonymous_variant	0.52	pyrazinamide
clpC1	4039097	c.1608G>C	synonymous_variant	0.56	pyrazinamide
clpC1	4039103	c.1602T>C	synonymous_variant	0.56	pyrazinamide
clpC1	4039106	c.1599G>C	synonymous_variant	0.61	pyrazinamide
clpC1	4039112	c.1593C>G	synonymous_variant	0.61	pyrazinamide
clpC1	4039121	c.1584T>C	synonymous_variant	0.67	pyrazinamide
clpC1	4039142	c.1563A>G	synonymous_variant	0.65	pyrazinamide
clpC1	4039145	c.1560G>C	synonymous_variant	0.65	pyrazinamide
clpC1	4039169	p.Glu512Asp	missense_variant	0.65	pyrazinamide
clpC1	4039172	c.1533A>G	synonymous_variant	0.65	pyrazinamide
clpC1	4039178	c.1527G>C	synonymous_variant	0.62	pyrazinamide
clpC1	4039183	c.1522T>C	synonymous_variant	0.65	pyrazinamide
clpC1	4039186	c.1519C>T	synonymous_variant	0.76	pyrazinamide
clpC1	4039226	c.1479T>C	synonymous_variant	0.47	pyrazinamide	Not assoc w R - Interim
clpC1	4039229	c.1476C>G	synonymous_variant	0.53	pyrazinamide
clpC1	4039286	c.1419T>C	synonymous_variant	0.38	pyrazinamide
clpC1	4039295	c.1410A>C	synonymous_variant	0.47	pyrazinamide
clpC1	4039298	c.1407T>C	synonymous_variant	0.47	pyrazinamide
clpC1	4039661	c.1044T>G	synonymous_variant	0.54	pyrazinamide
clpC1	4039664	c.1041G>C	synonymous_variant	0.47	pyrazinamide
clpC1	4039694	c.1011G>C	synonymous_variant	0.45	pyrazinamide
clpC1	4039724	c.981A>G	synonymous_variant	0.44	pyrazinamide
clpC1	4039751	c.954A>G	synonymous_variant	0.42	pyrazinamide
clpC1	4039757	c.948A>G	synonymous_variant	0.42	pyrazinamide
clpC1	4039760	c.945T>C	synonymous_variant	0.42	pyrazinamide
clpC1	4039766	c.939T>C	synonymous_variant	0.44	pyrazinamide
clpC1	4039769	c.936C>G	synonymous_variant	0.44	pyrazinamide
clpC1	4039775	c.930G>C	synonymous_variant	0.48	pyrazinamide
clpC1	4039778	c.927A>G	synonymous_variant	0.48	pyrazinamide
clpC1	4039781	c.924G>C	synonymous_variant	0.5	pyrazinamide
clpC1	4039790	c.915C>G	synonymous_variant	0.52	pyrazinamide
clpC1	4039817	c.888A>C	synonymous_variant	0.5	pyrazinamide	Not assoc w R - Interim
clpC1	4039820	c.885T>G	synonymous_variant	0.5	pyrazinamide
clpC1	4039826	c.879C>G	synonymous_variant	0.56	pyrazinamide
clpC1	4039831	c.874T>C	synonymous_variant	0.56	pyrazinamide
clpC1	4039850	c.855T>C	synonymous_variant	0.59	pyrazinamide
clpC1	4039865	c.840T>C	synonymous_variant	0.54	pyrazinamide
clpC1	4039898	c.807C>G	synonymous_variant	0.58	pyrazinamide
clpC1	4039928	c.775_777delAGCinsTCG	synonymous_variant	0.37	pyrazinamide
clpC1	4039931	c.774T>C	synonymous_variant	0.37	pyrazinamide
clpC1	4039937	c.768G>C	synonymous_variant	0.37	pyrazinamide
clpC1	4039946	c.759A>C	synonymous_variant	0.4	pyrazinamide
clpC1	4039952	c.753T>C	synonymous_variant	0.43	pyrazinamide
clpC1	4039979	c.726C>G	synonymous_variant	0.33	pyrazinamide
clpC1	4039988	c.717C>G	synonymous_variant	0.35	pyrazinamide
clpC1	4039991	c.714G>C	synonymous_variant	0.35	pyrazinamide
clpC1	4040021	c.684A>C	synonymous_variant	0.38	pyrazinamide	Not assoc w R - Interim
clpC1	4040024	c.681A>G	synonymous_variant	0.38	pyrazinamide
clpC1	4040090	c.613_615delTCTinsAGC	synonymous_variant	0.4	pyrazinamide
clpC1	4040093	c.612C>G	synonymous_variant	0.4	pyrazinamide	Not assoc w R - Interim
clpC1	4040105	c.600C>G	synonymous_variant	0.47	pyrazinamide
clpC1	4040147	c.558A>G	synonymous_variant	0.47	pyrazinamide	Not assoc w R - Interim
clpC1	4040162	c.543G>C	synonymous_variant	0.43	pyrazinamide	Not assoc w R - Interim
clpC1	4040171	c.534C>G	synonymous_variant	0.47	pyrazinamide
clpC1	4040201	c.504C>G	synonymous_variant	0.5	pyrazinamide
clpC1	4040204	c.501G>C	synonymous_variant	0.44	pyrazinamide
clpC1	4040207	c.498T>G	synonymous_variant	0.44	pyrazinamide
clpC1	4040210	c.495G>C	synonymous_variant	0.44	pyrazinamide
clpC1	4040213	c.490_492delTCTinsAGC	synonymous_variant	0.44	pyrazinamide
clpC1	4040225	c.480A>C	synonymous_variant	0.48	pyrazinamide
clpC1	4040228	c.477G>T	synonymous_variant	0.48	pyrazinamide
clpC1	4040231	c.474C>T	synonymous_variant	0.48	pyrazinamide
clpC1	4040237	c.468C>T	synonymous_variant	0.48	pyrazinamide
clpC1	4040246	c.459C>G	synonymous_variant	0.48	pyrazinamide
clpC1	4040249	c.456A>G	synonymous_variant	0.48	pyrazinamide
clpC1	4040267	c.438A>G	synonymous_variant	0.53	pyrazinamide	Not assoc w R - Interim
clpC1	4040273	c.432T>C	synonymous_variant	0.5	pyrazinamide	Not assoc w R - Interim
clpC1	4040277	c.427_428delTCinsAG	synonymous_variant	0.44	pyrazinamide
clpC1	4040279	c.426C>G	synonymous_variant	0.44	pyrazinamide	Not assoc w R - Interim
clpC1	4040291	c.414G>C	synonymous_variant	0.44	pyrazinamide
clpC1	4040318	c.387C>G	synonymous_variant	0.52	pyrazinamide
clpC1	4040330	c.375C>G	synonymous_variant	0.69	pyrazinamide
clpC1	4040342	c.363C>G	synonymous_variant	0.69	pyrazinamide
clpC1	4040354	c.351A>G	synonymous_variant	0.71	pyrazinamide
clpC1	4040363	c.342A>T	synonymous_variant	0.77	pyrazinamide
clpC1	4040369	c.336C>G	synonymous_variant	0.77	pyrazinamide
clpC1	4040380	c.325T>C	synonymous_variant	0.75	pyrazinamide
clpC1	4040381	c.324T>C	synonymous_variant	0.75	pyrazinamide
clpC1	4040387	c.318A>G	synonymous_variant	0.75	pyrazinamide
clpC1	4040393	c.312G>C	synonymous_variant	0.56	pyrazinamide	Not assoc w R - Interim
clpC1	4040411	c.294T>C	synonymous_variant	0.64	pyrazinamide	Not assoc w R - Interim
clpC1	4040423	c.282A>G	synonymous_variant	0.64	pyrazinamide	Not assoc w R - Interim
clpC1	4040426	c.279T>C	synonymous_variant	0.64	pyrazinamide
clpC1	4040431	c.274T>C	synonymous_variant	0.67	pyrazinamide
clpC1	4040444	c.261C>T	synonymous_variant	0.69	pyrazinamide
clpC1	4040450	c.255A>G	synonymous_variant	0.64	pyrazinamide	Not assoc w R - Interim
clpC1	4040459	c.246C>G	synonymous_variant	0.64	pyrazinamide
clpC1	4040465	c.240T>C	synonymous_variant	0.64	pyrazinamide
clpC1	4040471	c.234T>C	synonymous_variant	0.56	pyrazinamide	Not assoc w R - Interim
clpC1	4040477	c.228G>C	synonymous_variant	0.56	pyrazinamide
clpC1	4040480	c.225T>G	synonymous_variant	0.56	pyrazinamide
clpC1	4040501	c.204C>T	synonymous_variant	0.5	pyrazinamide	Not assoc w R - Interim
clpC1	4040517	p.Val63Ala	missense_variant	0.53	pyrazinamide	Not assoc w R - Interim
glpK	4138643	c.1113A>C	synonymous_variant	0.24	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138646	c.1110G>C	synonymous_variant	0.23	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138654	c.1102C>T	synonymous_variant	0.29	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
glpK	4138670	c.1086G>C	synonymous_variant	0.28	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138679	c.1075_1077delATGinsGC	frameshift_variant&missense_variant	0.32	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
glpK	4138695	p.Pro354Asp	missense_variant	0.35	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138718	c.1038T>C	synonymous_variant	0.33	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138721	c.1035G>A	synonymous_variant	0.33	ethambutol	Not assoc w R - Interim
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					levofloxacin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
glpK	4138724	c.1032A>G	synonymous_variant	0.38	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138730	c.1026C>G	synonymous_variant	0.35	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138757	c.999A>G	synonymous_variant	0.37	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138763	c.993G>A	synonymous_variant	0.35	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138769	c.987G>C	synonymous_variant	0.38	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138774	p.Ser328Ala	missense_variant	0.38	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138778	c.978C>G	synonymous_variant	0.38	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138796	c.960A>G	synonymous_variant	0.38	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138802	c.954G>A	synonymous_variant	0.31	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138808	c.948G>T	synonymous_variant	0.32	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138817	c.939T>C	synonymous_variant	0.3	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138822	p.Asn312Asp	missense_variant	0.3	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138829	c.927A>G	synonymous_variant	0.31	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138838	c.918G>C	synonymous_variant	0.26	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139432	c.324C>T	synonymous_variant	0.47	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139447	c.307_309delCACinsAG	frameshift_variant&missense_variant	0.41	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
glpK	4139450	c.306G>C	synonymous_variant	0.37	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139453	c.303T>C	synonymous_variant	0.37	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139459	c.297A>C	synonymous_variant	0.35	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139474	c.282T>C	synonymous_variant	0.42	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139477	c.279A>G	synonymous_variant	0.42	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139483	c.273C>G	synonymous_variant	0.42	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139486	c.270T>C	synonymous_variant	0.42	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139489	c.267G>T	synonymous_variant	0.47	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin	Not assoc w R - Interim
					levofloxacin	Not assoc w R - Interim
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
glpK	4139494	c.262T>C	synonymous_variant	0.53	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139504	c.250_252delGATinsAC	frameshift_variant&synonymous_variant	0.53	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
glpK	4139515	p.Ser81Ala	missense_variant	0.62	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139516	c.240A>G	synonymous_variant	0.62	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139524	p.Thr78Ala	missense_variant	0.62	ethambutol
					moxifloxacin	Uncertain significance
					streptomycin
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
glpK	4139526	p.Ala77Arg	missense_variant	0.62	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139537	c.219G>C	synonymous_variant	0.62	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139541	p.Ile72Thr	missense_variant	0.62	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139545	c.211T>C	synonymous_variant	0.62	ethambutol
					moxifloxacin	Not assoc w R - Interim
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139552	c.202_204delGCGinsTC	frameshift_variant&missense_variant	0.62	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
glpK	4139561	c.195G>A	synonymous_variant	0.73	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139581	p.Asn59Asp	missense_variant	0.67	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
glpK	4139588	c.168G>C	synonymous_variant	0.67	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4139651	c.103_105delCACinsGG	frameshift_variant&missense_variant	0.55	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
embC	4239623	c.-240C>T	upstream_gene_variant	1.0	ethambutol
embC	4240671	p.Thr270Ile	missense_variant	1.0	ethambutol	Not assoc w R
embC	4240780	c.918T>C	synonymous_variant	0.27	ethambutol
embC	4240783	c.921G>C	synonymous_variant	0.26	ethambutol
embC	4240789	c.927T>C	synonymous_variant	0.26	ethambutol
embC	4241042	p.Asn394Asp	missense_variant	0.69	ethambutol	Not assoc w R
embC	4241140	c.1278A>G	synonymous_variant	0.29	ethambutol	Not assoc w R - Interim
embC	4241146	c.1284C>G	synonymous_variant	0.29	ethambutol
embC	4241173	c.1311C>T	synonymous_variant	0.27	ethambutol
embC	4241203	c.1341T>C	synonymous_variant	0.3	ethambutol
embC	4241206	c.1344G>C	synonymous_variant	0.3	ethambutol	Not assoc w R - Interim
embC	4241218	c.1356G>C	synonymous_variant	0.3	ethambutol
embC	4241449	c.1587C>G	synonymous_variant	0.28	ethambutol
embC	4241453	p.Ile531Val	missense_variant	0.28	ethambutol
embC	4241479	c.1617C>G	synonymous_variant	0.32	ethambutol
embC	4241480	c.1618T>C	synonymous_variant	0.34	ethambutol
embC	4241488	c.1626G>C	synonymous_variant	0.4	ethambutol
embC	4241496	p.Ala545Gly	missense_variant	0.4	ethambutol
embC	4241500	c.1638A>C	synonymous_variant	0.38	ethambutol
embC	4241501	p.Ser547Thr	missense_variant	0.38	ethambutol
embC	4241506	c.1644G>C	synonymous_variant	0.38	ethambutol
embC	4241518	c.1656A>G	synonymous_variant	0.36	ethambutol
embC	4241521	c.1659T>C	synonymous_variant	0.36	ethambutol	Not assoc w R - Interim
embC	4241530	c.1668C>A	synonymous_variant	0.39	ethambutol
embC	4241536	c.1674A>G	synonymous_variant	0.39	ethambutol
embC	4241539	c.1677T>C	synonymous_variant	0.43	ethambutol	Not assoc w R - Interim
embC	4241545	c.1683T>C	synonymous_variant	0.44	ethambutol
embC	4241548	c.1686T>C	synonymous_variant	0.44	ethambutol
embC	4241551	c.1689A>G	synonymous_variant	0.44	ethambutol
embC	4241567	p.Ile569Val	missense_variant	0.55	ethambutol
embC	4241572	c.1710C>G	synonymous_variant	0.55	ethambutol
embC	4241578	c.1716G>C	synonymous_variant	0.48	ethambutol
embC	4241584	c.1722T>C	synonymous_variant	0.48	ethambutol
embC	4241587	c.1725C>G	synonymous_variant	0.48	ethambutol
embC	4241591	p.Leu577Val	missense_variant	0.48	ethambutol
embC	4241611	c.1749G>C	synonymous_variant	0.39	ethambutol
embC	4241614	c.1752A>C	synonymous_variant	0.35	ethambutol
embC	4241626	c.1764T>C	synonymous_variant	0.41	ethambutol
embA	4243580	c.348G>A	synonymous_variant	1.0	ethambutol	Not assoc w R
embA	4244420	c.1188G>C	synonymous_variant	1.0	ethambutol	Not assoc w R
embA	4245182	c.1950T>C	synonymous_variant	0.5	ethambutol
embA	4245189	c.1957C>T	synonymous_variant	0.5	ethambutol
embA	4245198	p.Leu656Ile	missense_variant	0.5	ethambutol
embA	4245207	c.1975T>C	synonymous_variant	0.45	ethambutol
embA	4245215	c.1983A>C	synonymous_variant	0.45	ethambutol
embA	4245222	c.1990_1992delTATinsCG	frameshift_variant&missense_variant	0.48	ethambutol	Uncertain significance
embA	4245248	c.2016G>C	synonymous_variant	0.41	ethambutol
embA	4245257	c.2025A>G	synonymous_variant	0.35	ethambutol
embA	4245263	c.2031A>G	synonymous_variant	0.29	ethambutol	Not assoc w R - Interim
embA	4245282	p.Ile684Val	missense_variant	0.29	ethambutol
embA	4245285	c.2053T>C	synonymous_variant	0.29	ethambutol
embA	4245290	c.2058C>G	synonymous_variant	0.27	ethambutol
embA	4245293	c.2061T>G	synonymous_variant	0.27	ethambutol
embA	4245296	c.2064G>C	synonymous_variant	0.27	ethambutol
embA	4245299	c.2067A>G	synonymous_variant	0.27	ethambutol
embB	4247646	p.Glu378Ala	missense_variant	1.0	ethambutol	Not assoc w R
embB	4247761	c.1248T>C	synonymous_variant	0.26	ethambutol
embB	4247773	c.1260G>A	synonymous_variant	0.35	ethambutol
embB	4247776	c.1263G>T	synonymous_variant	0.4	ethambutol
embB	4247797	c.1284C>G	synonymous_variant	0.48	ethambutol
embB	4247800	c.1287A>T	synonymous_variant	0.42	ethambutol
embB	4247803	c.1290G>C	synonymous_variant	0.48	ethambutol
embB	4247815	c.1302C>G	synonymous_variant	0.48	ethambutol
embB	4247819	c.1306_1308delGTTinsAC	frameshift_variant&missense_variant	0.48	ethambutol
embB	4247830	c.1317A>G	synonymous_variant	0.48	ethambutol	Not assoc w R - Interim
embB	4247836	c.1323A>G	synonymous_variant	0.43	ethambutol	Not assoc w R - Interim
embB	4247866	c.1353G>C	synonymous_variant	0.42	ethambutol
embB	4247875	c.1362G>C	synonymous_variant	0.43	ethambutol
embB	4247876	c.1363C>T	synonymous_variant	0.43	ethambutol
embB	4247881	c.1368G>C	synonymous_variant	0.4	ethambutol
embB	4247887	c.1374C>T	synonymous_variant	0.4	ethambutol	Not assoc w R - Interim
embB	4247893	c.1380C>T	synonymous_variant	0.4	ethambutol
embB	4247899	p.Met462Ile	missense_variant	0.48	ethambutol
embB	4247905	c.1392G>C	synonymous_variant	0.48	ethambutol	Not assoc w R - Interim
embB	4247909	c.1396T>C	synonymous_variant	0.54	ethambutol
embB	4247932	c.1419C>G	synonymous_variant	0.45	ethambutol
embB	4247940	p.Leu476Trp	missense_variant	0.57	ethambutol
embB	4247945	c.1432T>C	synonymous_variant	0.57	ethambutol
embB	4247951	p.Ser480Ala	missense_variant	0.6	ethambutol
embB	4247956	c.1443G>C	synonymous_variant	0.6	ethambutol	Not assoc w R - Interim
embB	4247974	c.1461C>G	synonymous_variant	0.61	ethambutol
embB	4248007	c.1494C>G	synonymous_variant	0.58	ethambutol
embB	4248011	p.Ser500Arg	missense_variant	0.58	ethambutol
embB	4248014	p.Thr501Ala	missense_variant	0.58	ethambutol	Uncertain significance
embB	4248035	p.Val508Ile	missense_variant	0.67	ethambutol
embB	4248040	c.1527C>G	synonymous_variant	0.67	ethambutol
embB	4248041	p.Ala510Thr	missense_variant	0.67	ethambutol	Uncertain significance
embB	4248044	p.Lys511Ala	missense_variant	0.67	ethambutol
embB	4248070	c.1557T>C	synonymous_variant	0.58	ethambutol
embB	4248085	c.1572T>C	synonymous_variant	0.46	ethambutol
embB	4248097	c.1584C>G	synonymous_variant	0.56	ethambutol
embB	4248130	c.1617G>C	synonymous_variant	0.5	ethambutol
embB	4248133	c.1620C>G	synonymous_variant	0.5	ethambutol
embB	4248139	c.1626C>G	synonymous_variant	0.5	ethambutol
embB	4248142	c.1629T>C	synonymous_variant	0.5	ethambutol
embB	4248143	c.1630T>C	synonymous_variant	0.5	ethambutol
embB	4248157	c.1644A>G	synonymous_variant	0.43	ethambutol	Not assoc w R - Interim
embB	4248199	c.1686A>G	synonymous_variant	0.35	ethambutol
embB	4248200	p.Ile563Val	missense_variant	0.35	ethambutol
embB	4248205	c.1692C>G	synonymous_variant	0.35	ethambutol
embB	4248206	c.1693_1695delAGCinsGT	frameshift_variant&missense_variant	0.35	ethambutol
embB	4248220	c.1707A>C	synonymous_variant	0.4	ethambutol
embB	4248304	c.1791G>C	synonymous_variant	0.5	ethambutol
embB	4248319	c.1806A>G	synonymous_variant	0.52	ethambutol
embB	4248343	c.1830G>C	synonymous_variant	0.5	ethambutol
embB	4248350	c.1837T>C	synonymous_variant	0.48	ethambutol
embB	4248355	c.1842A>G	synonymous_variant	0.5	ethambutol
embB	4248407	p.Leu632Val	missense_variant	0.35	ethambutol
embB	4248410	c.1897_1899delTTCinsCG	frameshift_variant&missense_variant	0.35	ethambutol
embB	4248419	p.Leu636Met	missense_variant	0.35	ethambutol
embB	4248425	c.1912T>C	synonymous_variant	0.35	ethambutol	Not assoc w R - Interim
embB	4248430	c.1917T>C	synonymous_variant	0.37	ethambutol
embB	4248432	p.Trp640Phe	missense_variant	0.37	ethambutol
ubiA	4269387	p.Glu149Asp	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269606	c.228T>C	synonymous_variant	1.0	ethambutol	Not assoc w R
aftB	4269687	c.-851C>T	upstream_gene_variant	1.0	ethambutol
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	capreomycin	Not assoc w R
					amikacin	Not assoc w R
					kanamycin	Not assoc w R
whiB6	4338603	c.-82C>T	upstream_gene_variant	1.0	capreomycin	Not assoc w R
					amikacin	Not assoc w R
					kanamycin	Not assoc w R
whiB6	4338732	c.-211C>T	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
gid	4407588	c.615A>G	synonymous_variant	1.0	streptomycin	Not assoc w R
gid	4407873	c.330G>T	synonymous_variant	1.0	streptomycin	Not assoc w R

TB-Profiler result