TB-Profiler result

Run: 118c36c3-b937-42fe-9a55-781a1e944e1a
Summary

Run ID: 118c36c3-b937-42fe-9a55-781a1e944e1a

Sample name:

Date: 30-08-2023 09:28:14

Number of reads: 621568

Percentage reads mapped: 63.07

Median coverage: 23

Strain: lineage3.1.1

Spoligotype:

Drug-resistance: Pre-XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.94
lineage3.1 East-African-Indian RD750 1.0
lineage3.1.1 East-African-Indian RD750 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R
ethambutol embB p.Met306Ile Assoc w R
p.Gln497Arg Assoc w R
pyrazinamide pncA p.Ser59Phe Uncertain significance
moxifloxacin gyrA p.Asp94Gly Assoc w R
levofloxacin gyrA p.Asp94Gly Assoc w R
bedaquiline
delamanid
pretomanid
linezolid
streptomycin rpsL p.Lys43Arg Assoc w R
rrs n.799C>T Uncertain significance
amikacin
kanamycin
capreomycin
clofazimine
ethionamide
para-aminosalicylic_acid
cycloserine
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7582 p.Asp94Gly missense_variant 0.78 ofloxacin Uncertain significance
moxifloxacin Assoc w R
levofloxacin Assoc w R
fluoroquinolones Uncertain significance
ciprofloxacin Uncertain significance
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin Assoc w R
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R
pncA 2289066 p.Ser59Phe missense_variant 0.96 pyrazinamide Uncertain significance
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol Assoc w R
embB 4248003 p.Gln497Arg missense_variant 1.0 ethambutol Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 5384 p.Val49Met missense_variant 0.1 fluoroquinolones
moxifloxacin
levofloxacin
ciprofloxacin
ofloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 fluoroquinolones
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
ciprofloxacin
ofloxacin
fgd1 491236 p.Gly152Ser missense_variant 0.13 delamanid
fgd1 491343 c.561C>T synonymous_variant 0.12 delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 delamanid
mshA 576521 p.Gly392Trp missense_variant 0.1 ethionamide
isoniazid
rpoB 759746 c.-61C>T upstream_gene_variant 1.0 rifampicin Uncertain significance
rpoB 759776 c.-31T>G upstream_gene_variant 0.23 rifampicin
rpoB 761990 c.2184G>C synonymous_variant 0.15 rifampicin
rpoB 762003 p.Asn733Gln missense_variant 0.15 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.15 rifampicin
rpoB 762016 p.Glu737Ala missense_variant 0.12 rifampicin
rpoB 762020 p.Glu738Asp missense_variant 0.13 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.17 rifampicin
rpoB 762057 p.Ile751Val missense_variant 0.17 rifampicin Uncertain significance
rpoB 762062 c.2256T>C synonymous_variant 0.14 rifampicin
rpoB 762065 c.2259T>G synonymous_variant 0.14 rifampicin
rpoB 762071 p.Asp755Glu missense_variant 0.16 rifampicin
rpoB 762083 c.2277T>C synonymous_variant 0.15 rifampicin
rpoB 762086 c.2280G>C synonymous_variant 0.16 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.17 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.17 rifampicin
rpoB 762122 p.Asp772Glu missense_variant 0.17 rifampicin
rpoB 762128 c.2322G>C synonymous_variant 0.19 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.19 rifampicin
rpoB 762134 c.2328C>G synonymous_variant 0.21 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.24 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.2 rifampicin
rpoB 762158 c.2352G>C synonymous_variant 0.2 rifampicin
rpoB 762167 c.2361T>C synonymous_variant 0.2 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.17 rifampicin
rpoB 762194 c.2388G>C synonymous_variant 0.2 rifampicin
rpoB 762234 p.Pro810Ser missense_variant 0.13 rifampicin
rpoB 762245 c.2439G>C synonymous_variant 0.13 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.13 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.13 rifampicin
rpoB 762266 c.2460T>G synonymous_variant 0.12 rifampicin
rpoC 762434 c.-936T>G upstream_gene_variant 1.0 rifampicin
rpoC 762827 c.-543G>C upstream_gene_variant 0.11 rifampicin
rpoC 762831 c.-539_-538delAGinsTC upstream_gene_variant 0.11 rifampicin
rpoB 762849 p.Tyr1015Glu missense_variant 0.11 rifampicin
rpoC 762854 c.-516G>C upstream_gene_variant 0.11 rifampicin
rpoB 762855 p.Val1017Ile missense_variant 0.12 rifampicin
rpoB 762858 p.Thr1018Ser missense_variant 0.12 rifampicin
rpoC 762863 c.-507T>C upstream_gene_variant 0.12 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.13 rifampicin
rpoC 762929 c.-441G>T upstream_gene_variant 0.19 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.24 rifampicin
rpoC 762995 c.-375G>C upstream_gene_variant 0.23 rifampicin
rpoB 763005 p.Cys1067Val missense_variant 0.2 rifampicin
rpoB 763014 p.Met1070Leu missense_variant 0.18 rifampicin
rpoB 763017 p.Gln1071Glu missense_variant 0.19 rifampicin
rpoC 763028 c.-342T>C upstream_gene_variant 0.22 rifampicin
rpoC 763031 c.-339T>C upstream_gene_variant 0.97 rifampicin
rpoB 763038 p.Thr1078Ala missense_variant 0.18 rifampicin
rpoC 763043 c.-327G>C upstream_gene_variant 0.19 rifampicin
rpoC 763052 c.-318G>C upstream_gene_variant 0.19 rifampicin
rpoC 763053 c.-317T>C upstream_gene_variant 0.22 rifampicin
rpoC 763058 c.-312C>G upstream_gene_variant 0.18 rifampicin
rpoC 763070 c.-300T>C upstream_gene_variant 0.21 rifampicin
rpoB 763074 p.Thr1090Val missense_variant 0.21 rifampicin
rpoB 763077 p.Val1091Thr missense_variant 0.22 rifampicin
rpoC 763088 c.-282C>G upstream_gene_variant 0.21 rifampicin
rpoC 763094 c.-276G>C upstream_gene_variant 0.2 rifampicin
rpoC 763103 c.-267G>C upstream_gene_variant 0.15 rifampicin
rpoC 763115 c.-255T>C upstream_gene_variant 0.16 rifampicin
rpoC 763511 p.Cys48Gly missense_variant 0.11 rifampicin
rpoC 763517 p.Lys50Gln missense_variant 0.1 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.19 rifampicin
rpoC 763578 p.Phe70Tyr missense_variant 0.24 rifampicin
rpoC 763609 c.240C>G synonymous_variant 0.25 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.23 rifampicin
rpoC 763622 p.Ala85Ser missense_variant 0.3 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.29 rifampicin
rpoC 763636 c.267T>C synonymous_variant 0.29 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.28 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.28 rifampicin
rpoC 763696 c.327T>C synonymous_variant 0.28 rifampicin
rpoC 763699 c.330G>C synonymous_variant 0.3 rifampicin
rpoC 763708 c.339G>C synonymous_variant 0.27 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.26 rifampicin
rpoC 763723 c.354G>C synonymous_variant 0.25 rifampicin
rpoC 763724 p.Asp119Asn missense_variant 0.25 rifampicin
rpoC 763729 c.360G>C synonymous_variant 0.25 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.25 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.2 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.19 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.15 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.15 rifampicin
rpoC 763772 p.Val135Met missense_variant 0.15 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.12 rifampicin
rpoC 764644 c.1275G>C synonymous_variant 0.12 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.14 rifampicin
rpoC 764672 p.Gln435Thr missense_variant 0.17 rifampicin
rpoC 764677 c.1308C>G synonymous_variant 0.17 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.16 rifampicin
rpoC 764706 p.Leu446Gln missense_variant 0.16 rifampicin
rpoC 764746 c.1377G>C synonymous_variant 0.18 rifampicin
rpoC 764749 c.1380G>C synonymous_variant 0.18 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.18 rifampicin
rpoC 764780 p.Ser471Ala missense_variant 0.19 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.18 rifampicin
rpoC 764804 p.Gln479Ser missense_variant 0.11 rifampicin
rpoC 764812 c.1443C>G synonymous_variant 0.11 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.11 rifampicin
rpoC 764817 p.Val483Gly missense_variant 0.89 rifampicin
rpoC 764824 c.1455T>C synonymous_variant 0.11 rifampicin
rpoC 764843 p.Ala492Arg missense_variant 0.12 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.14 rifampicin
rpoC 764863 c.1494G>C synonymous_variant 0.14 rifampicin
rpoC 764872 c.1503A>G synonymous_variant 0.17 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.17 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.15 rifampicin
rpoC 764888 c.1519T>C synonymous_variant 0.15 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.15 rifampicin
rpoC 764902 c.1533C>G synonymous_variant 0.15 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.15 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.16 rifampicin
rpoC 764920 c.1551G>C synonymous_variant 0.16 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.19 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.19 rifampicin
rpoC 764941 c.1572G>C synonymous_variant 0.18 rifampicin
rpoC 764948 c.1579_1581delTTGinsCTC synonymous_variant 0.18 rifampicin
rpoC 764953 c.1584G>C synonymous_variant 0.18 rifampicin
rpoC 764956 c.1587T>C synonymous_variant 0.18 rifampicin
rpoC 764958 p.Glu530Gly missense_variant 0.18 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.17 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
mmpL5 776984 p.Phe499Leu missense_variant 0.12 clofazimine
bedaquiline
mmpL5 777083 c.1398C>T synonymous_variant 0.11 clofazimine
bedaquiline
mmpR5 779127 c.139dupG frameshift_variant 0.5 clofazimine Uncertain significance
bedaquiline Uncertain significance
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.12 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.1 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.3 linezolid
kanamycin Uncertain significance
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472123 n.278A>G non_coding_transcript_exon_variant 0.1 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.29 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.28 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.41 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.36 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472287 n.442C>T non_coding_transcript_exon_variant 0.39 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.39 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.39 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472293 n.448C>A non_coding_transcript_exon_variant 0.37 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472314 n.469A>G non_coding_transcript_exon_variant 0.35 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.37 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.35 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.34 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.34 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.32 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.38 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin Uncertain significance
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.31 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.26 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.23 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.13 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472426 n.581T>C non_coding_transcript_exon_variant 0.13 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472435 n.589_590insC non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472437 n.592T>C non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472438 n.594delC non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472448 n.603T>G non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472450 n.605A>G non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472451 n.606C>G non_coding_transcript_exon_variant 0.16 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472456 n.611T>C non_coding_transcript_exon_variant 0.1 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.1 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.15 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472462 n.617T>C non_coding_transcript_exon_variant 0.17 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472464 n.619A>C non_coding_transcript_exon_variant 0.12 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472467 n.622G>C non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472471 n.626G>A non_coding_transcript_exon_variant 0.18 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472474 n.629C>G non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472476 n.631A>G non_coding_transcript_exon_variant 0.11 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.2 linezolid
kanamycin Uncertain significance
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.2 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.26 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin Uncertain significance
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.56 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.6 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.62 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.62 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.62 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472673 n.828T>A non_coding_transcript_exon_variant 0.59 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472674 n.829T>C non_coding_transcript_exon_variant 0.57 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.59 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.59 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.59 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.59 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.58 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.58 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.56 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.38 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.26 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.26 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.26 linezolid
kanamycin Uncertain significance
capreomycin
amikacin
aminoglycosides
streptomycin Uncertain significance
rrs 1472836 n.991G>A non_coding_transcript_exon_variant 0.23 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472840 n.995A>C non_coding_transcript_exon_variant 0.22 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472844 n.999C>A non_coding_transcript_exon_variant 0.22 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472845 n.1000G>A non_coding_transcript_exon_variant 0.19 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.22 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.2 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472867 n.1022T>G non_coding_transcript_exon_variant 0.23 linezolid
kanamycin Uncertain significance
capreomycin
amikacin
aminoglycosides
streptomycin Uncertain significance
rrs 1472868 n.1023T>C non_coding_transcript_exon_variant 0.2 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472869 n.1024G>A non_coding_transcript_exon_variant 0.2 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472870 n.1025T>A non_coding_transcript_exon_variant 0.21 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472873 n.1028C>T non_coding_transcript_exon_variant 0.2 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472875 n.1030T>G non_coding_transcript_exon_variant 0.2 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.26 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.35 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.41 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.4 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin Uncertain significance
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.41 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.41 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.41 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.41 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.4 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.42 linezolid
kanamycin
capreomycin
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.52 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.55 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.65 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.69 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.7 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.76 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.72 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.71 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.73 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.73 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.74 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.73 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.73 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.73 linezolid
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
aminoglycosides
streptomycin
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.68 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.61 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.55 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.53 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.51 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.48 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.43 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.42 linezolid
kanamycin
capreomycin
amikacin
aminoglycosides
streptomycin
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.13 linezolid
rrl 1473746 n.89T>G non_coding_transcript_exon_variant 0.13 linezolid
rrl 1473750 n.93C>A non_coding_transcript_exon_variant 0.13 linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.15 linezolid
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.16 linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.16 linezolid
rrl 1473768 n.111A>G non_coding_transcript_exon_variant 0.17 linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.2 linezolid
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.2 linezolid
rrl 1473791 n.134A>C non_coding_transcript_exon_variant 0.19 linezolid
rrl 1473792 n.135C>A non_coding_transcript_exon_variant 0.2 linezolid
rrl 1473797 n.140G>C non_coding_transcript_exon_variant 0.21 linezolid
rrl 1473803 n.146G>T non_coding_transcript_exon_variant 0.21 linezolid
rrl 1473804 n.147T>G non_coding_transcript_exon_variant 0.21 linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.22 linezolid
rrl 1473814 n.157A>G non_coding_transcript_exon_variant 0.22 linezolid
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.23 linezolid
rrl 1473828 n.172_173insCG non_coding_transcript_exon_variant 0.22 linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.22 linezolid
rrl 1473835 n.179delA non_coding_transcript_exon_variant 0.23 linezolid
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.21 linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.21 linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.19 linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.18 linezolid
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.19 linezolid
rrl 1473922 n.265A>T non_coding_transcript_exon_variant 0.19 linezolid
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.19 linezolid
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 0.11 linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.24 linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.29 linezolid
rrl 1474264 n.607T>G non_coding_transcript_exon_variant 0.26 linezolid
rrl 1474265 n.608G>A non_coding_transcript_exon_variant 0.26 linezolid
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.25 linezolid Uncertain significance
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.23 linezolid
rrl 1474290 n.633T>A non_coding_transcript_exon_variant 0.23 linezolid
rrl 1474293 n.636T>G non_coding_transcript_exon_variant 0.22 linezolid
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.28 linezolid
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.28 linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.33 linezolid
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.33 linezolid
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.34 linezolid
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.35 linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.35 linezolid
rrl 1474381 n.724T>A non_coding_transcript_exon_variant 0.4 linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.4 linezolid
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.3 linezolid
rrl 1474406 n.749T>C non_coding_transcript_exon_variant 0.3 linezolid
rrl 1474412 n.756_779delACCCACACGCGCATACGCGCGTGT non_coding_transcript_exon_variant 0.23 linezolid
rrl 1474438 n.781A>T non_coding_transcript_exon_variant 0.19 linezolid
rrl 1474440 n.783T>C non_coding_transcript_exon_variant 0.18 linezolid
rrl 1474444 n.787G>C non_coding_transcript_exon_variant 0.18 linezolid
rrl 1474450 n.793T>C non_coding_transcript_exon_variant 0.18 linezolid
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.18 linezolid
rrl 1474483 n.826C>G non_coding_transcript_exon_variant 0.36 linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.43 linezolid
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.41 linezolid
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.42 linezolid
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.43 linezolid
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.43 linezolid
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.45 linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.41 linezolid
rrl 1474551 n.894G>C non_coding_transcript_exon_variant 0.43 linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.4 linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.4 linezolid
rrl 1474628 n.971C>T non_coding_transcript_exon_variant 0.4 linezolid
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.4 linezolid
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.4 linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.4 linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.4 linezolid
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.4 linezolid
rrl 1474676 n.1019T>A non_coding_transcript_exon_variant 0.55 linezolid
rrl 1474692 n.1035G>A non_coding_transcript_exon_variant 0.52 linezolid
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.46 linezolid
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.45 linezolid
rrl 1474721 n.1064G>A non_coding_transcript_exon_variant 0.46 linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.46 linezolid
rrl 1474740 n.1083G>C non_coding_transcript_exon_variant 0.45 linezolid
rrl 1474747 n.1090C>G non_coding_transcript_exon_variant 0.49 linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.51 linezolid
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.49 linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.53 linezolid
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.51 linezolid
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.53 linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.55 linezolid
rrl 1474800 n.1143T>C non_coding_transcript_exon_variant 0.17 linezolid
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.53 linezolid
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.49 linezolid
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.49 linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.29 linezolid
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.13 linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.14 linezolid
rrl 1475655 n.1998T>G non_coding_transcript_exon_variant 0.17 linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.2 linezolid
rrl 1475757 n.2100A>C non_coding_transcript_exon_variant 0.39 linezolid
rrl 1475759 n.2102C>G non_coding_transcript_exon_variant 0.4 linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.42 linezolid
rrl 1475776 n.2119G>C non_coding_transcript_exon_variant 0.42 linezolid
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.47 linezolid
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.49 linezolid
rrl 1475892 n.2235A>G non_coding_transcript_exon_variant 0.48 linezolid
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.48 linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.5 linezolid
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.48 linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.48 linezolid
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.53 linezolid
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.53 linezolid
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.52 linezolid
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.55 linezolid
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.56 linezolid
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.54 linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.56 linezolid Uncertain significance
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.5 linezolid
rrl 1476024 n.2367T>C non_coding_transcript_exon_variant 0.24 linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.26 linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.23 linezolid
rrl 1476034 n.2377C>T non_coding_transcript_exon_variant 0.26 linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.26 linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.26 linezolid
rrl 1476045 n.2388G>A non_coding_transcript_exon_variant 0.23 linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.23 linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.27 linezolid
rrl 1476057 n.2400T>C non_coding_transcript_exon_variant 0.24 linezolid
rrl 1476058 n.2401T>C non_coding_transcript_exon_variant 0.24 linezolid
rrl 1476076 n.2419A>G non_coding_transcript_exon_variant 0.23 linezolid
rrl 1476082 n.2425T>C non_coding_transcript_exon_variant 0.23 linezolid
rrl 1476085 n.2428G>C non_coding_transcript_exon_variant 0.23 linezolid
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.23 linezolid
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.21 linezolid
rrl 1476100 n.2443A>T non_coding_transcript_exon_variant 0.2 linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.2 linezolid
rrl 1476105 n.2450delA non_coding_transcript_exon_variant 0.2 linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.19 linezolid
rrl 1476113 n.2456T>A non_coding_transcript_exon_variant 0.19 linezolid
rrl 1476114 n.2457T>C non_coding_transcript_exon_variant 0.17 linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.19 linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.24 linezolid
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.22 linezolid
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.34 linezolid
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.32 linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.36 linezolid
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.36 linezolid
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.43 linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.49 linezolid
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.54 linezolid
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.54 linezolid
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.54 linezolid
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.55 linezolid Uncertain significance
rrl 1476279 n.2622G>A non_coding_transcript_exon_variant 0.5 linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.55 linezolid
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.5 linezolid
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.49 linezolid
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.49 linezolid
rrl 1476297 n.2640C>G non_coding_transcript_exon_variant 0.51 linezolid
rrl 1476298 n.2641C>G non_coding_transcript_exon_variant 0.51 linezolid
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.54 linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.54 linezolid
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.54 linezolid
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.51 linezolid
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.5 linezolid
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.58 linezolid
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.55 linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.5 linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.45 linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.45 linezolid
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.41 linezolid
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.38 linezolid
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.38 linezolid
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.38 linezolid
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.36 linezolid
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.35 linezolid
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.35 linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.37 linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.29 linezolid
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.29 linezolid
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.28 linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.28 linezolid
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.3 linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.28 linezolid
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.29 linezolid
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.3 linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.3 linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.29 linezolid
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.29 linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.29 linezolid
rrl 1476661 n.3004A>G non_coding_transcript_exon_variant 0.21 linezolid
rrl 1476665 n.3008T>G non_coding_transcript_exon_variant 0.13 linezolid
rrl 1476668 n.3011C>T non_coding_transcript_exon_variant 0.12 linezolid
rrl 1476675 n.3018C>G non_coding_transcript_exon_variant 0.13 linezolid
rpsA 1833803 p.Ala88Thr missense_variant 0.12 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.13 pyrazinamide
rpsA 1833842 p.Ile101Leu missense_variant 0.13 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.13 pyrazinamide
rpsA 1833850 c.309C>G synonymous_variant 0.13 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.13 pyrazinamide
rpsA 1833862 c.321G>C synonymous_variant 0.13 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.19 pyrazinamide
rpsA 1833881 p.Gly114Ser missense_variant 0.19 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833893 p.Ala118Lys missense_variant 0.18 pyrazinamide
rpsA 1833896 p.Leu119Ile missense_variant 0.19 pyrazinamide
rpsA 1833905 p.Lys122Glu missense_variant 0.16 pyrazinamide
rpsA 1833912 p.Glu124Gly missense_variant 0.16 pyrazinamide
rpsA 1833915 p.Ala125Val missense_variant 0.14 pyrazinamide
rpsA 1833921 p.Lys127Thr missense_variant 0.13 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.21 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.14 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.11 pyrazinamide
rpsA 1834046 p.Ile169Leu missense_variant 0.11 pyrazinamide
rpsA 1834054 c.513C>G synonymous_variant 0.1 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.13 pyrazinamide
rpsA 1834451 c.910_912delTTGinsCTC synonymous_variant 0.19 pyrazinamide
rpsA 1834456 c.915T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834486 p.Glu315Asp missense_variant 0.19 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834501 c.960G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834523 p.Glu328Gln missense_variant 0.17 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834543 c.1002C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834546 p.Asp335Glu missense_variant 0.15 pyrazinamide
rpsA 1834552 c.1013_1015delTTG disruptive_inframe_deletion 0.15 pyrazinamide
rpsA 1834558 c.1017_1018insAAG conservative_inframe_insertion 0.15 pyrazinamide
rpsA 1834570 p.Asp343Glu missense_variant 0.12 pyrazinamide
rpsA 1834572 p.Ala344Val missense_variant 0.12 pyrazinamide
rpsA 1834574 p.Met345Phe missense_variant 0.12 pyrazinamide
rpsA 1834603 p.Glu354Asp missense_variant 0.14 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834612 c.1071G>C synonymous_variant 0.11 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Uncertain significance
katG 2155570 p.Phe181Tyr missense_variant 0.1 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170461 p.Gly51Glu missense_variant 1.0 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
pncA 2289047 c.195C>T synonymous_variant 1.0 pyrazinamide
pncA 2289365 c.-125delC upstream_gene_variant 1.0 pyrazinamide
eis 2714978 p.His119Tyr missense_variant 0.11 kanamycin
amikacin
ahpC 2726105 c.-88G>A upstream_gene_variant 1.0 isoniazid Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448533 c.30C>A synonymous_variant 0.14 ethionamide
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0 capreomycin
amikacin
Rv3236c 3613131 c.-15A>G upstream_gene_variant 0.1 pyrazinamide
rpoA 3878597 c.-90G>A upstream_gene_variant 0.12 rifampicin
clpC1 4039383 p.Ala441Asp missense_variant 0.18 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039397 c.1308A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039406 c.1299G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039412 p.Ala431Val missense_variant 0.14 pyrazinamide
clpC1 4039424 p.Lys427Arg missense_variant 0.14 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039435 p.Phe424Leu missense_variant 0.13 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.12 pyrazinamide
clpC1 4039445 p.Asp420Glu missense_variant 0.11 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.11 pyrazinamide
clpC1 4039454 c.1251A>C synonymous_variant 0.1 pyrazinamide
clpC1 4039457 c.1248C>G synonymous_variant 0.1 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039477 p.Met410Leu missense_variant 0.13 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.13 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039499 c.1206G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039508 c.1197G>C synonymous_variant 0.13 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.12 pyrazinamide
clpC1 4039533 p.Asn391Ser missense_variant 0.11 pyrazinamide
clpC1 4039537 p.Ile390Val missense_variant 0.11 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039556 c.1149G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039568 p.Met379Leu missense_variant 0.12 pyrazinamide
clpC1 4039571 c.1134G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039575 p.Ala377Glu missense_variant 0.12 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.12 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039619 c.1086G>T synonymous_variant 0.12 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.12 pyrazinamide
clpC1 4039647 p.Glu353Ala missense_variant 0.11 pyrazinamide
clpC1 4039649 p.Val352Leu missense_variant 0.11 pyrazinamide
clpC1 4039661 p.Gly348Ala missense_variant 0.12 pyrazinamide
clpC1 4039670 p.Val345Ile missense_variant 0.11 pyrazinamide
clpC1 4039691 c.1014G>C synonymous_variant 0.11 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.1 pyrazinamide
clpC1 4039697 c.1008C>A synonymous_variant 0.1 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.1 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.1 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.1 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.15 pyrazinamide
clpC1 4040001 p.His235Arg missense_variant 0.15 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040010 p.Ala232Asp missense_variant 0.15 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.15 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.14 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.12 pyrazinamide
clpC1 4040645 c.60C>G synonymous_variant 0.12 pyrazinamide
clpC1 4040657 c.48T>C synonymous_variant 0.13 pyrazinamide
clpC1 4040660 c.45G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040669 c.36C>G synonymous_variant 0.14 pyrazinamide
clpC1 4040672 c.31_33delAGGinsCGT synonymous_variant 0.15 pyrazinamide
clpC1 4040675 c.30C>T synonymous_variant 0.15 pyrazinamide
clpC1 4040699 c.6C>T synonymous_variant 0.15 pyrazinamide
embC 4241562 p.Arg567His missense_variant 1.0 ethambutol Uncertain significance
embC 4242075 p.Arg738Gln missense_variant 1.0 ethambutol Uncertain significance
embA 4242643 c.-590C>T upstream_gene_variant 1.0 ethambutol
embB 4246869 p.Ser119Asn missense_variant 1.0 ethambutol Uncertain significance
ethA 4327968 c.-495C>T upstream_gene_variant 0.12 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 streptomycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin
gid 4408302 c.-100A>G upstream_gene_variant 0.11 streptomycin