Run ID: ERR11465352
Sample name:
Date: 2024-10-05T08:01:04.564193
Number of reads: 2213184
Percentage reads mapped: 82.69
Median coverage: 50.0
Strain: lineage4.3.4.1
Spoligotype:
Drug-resistance: Sensitive
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4.3 | Euro-American (LAM) | None | 1.0 |
lineage4.3.4.1 | Euro-American (LAM) | RD174 | 1.0 |
lineage4 | Euro-American | None | 1.0 |
lineage4.3.4 | Euro-American (LAM) | RD174 | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
dnaA | 1011 | c.1011C>G | synonymous_variant | 0.15 | isoniazid | |
dnaA | 1024 | c.1024T>C | synonymous_variant | 0.15 | isoniazid | |
dnaA | 1035 | c.1035A>G | synonymous_variant | 0.2 | isoniazid | |
dnaA | 1038 | c.1038A>C | synonymous_variant | 0.2 | isoniazid | |
dnaA | 1047 | p.Glu349Asp | missense_variant | 0.21 | isoniazid | |
dnaA | 1055 | p.Ala352Asp | missense_variant | 0.21 | isoniazid | |
dnaA | 1065 | c.1065C>T | synonymous_variant | 0.21 | isoniazid | Not assoc w R - Interim |
dnaA | 1068 | c.1068T>C | synonymous_variant | 0.21 | isoniazid | |
dnaA | 1077 | c.1077A>G | synonymous_variant | 0.21 | isoniazid | |
dnaA | 1098 | c.1098A>G | synonymous_variant | 0.16 | isoniazid | |
dnaA | 1104 | c.1104T>C | synonymous_variant | 0.14 | isoniazid | |
gyrA | 6592 | c.-710C>G | upstream_gene_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6595 | c.1356G>A | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6862 | c.1623C>G | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 6869 | c.-433T>C | upstream_gene_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6872 | c.-430T>C | upstream_gene_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6878 | c.1639T>C | synonymous_variant | 0.17 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6881 | c.1642T>C | synonymous_variant | 0.19 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6896 | p.Arg553Lys | missense_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7120 | c.-182T>C | upstream_gene_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7129 | c.-173T>G | upstream_gene_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7132 | c.-170T>G | upstream_gene_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7136 | c.-166T>C | upstream_gene_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7144 | c.-158A>G | upstream_gene_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7145 | p.Val636Ile | missense_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7153 | c.1914G>C | synonymous_variant | 0.2 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7162 | c.-140C>G | upstream_gene_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7165 | c.-137C>G | upstream_gene_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7177 | c.-125G>A | upstream_gene_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7178 | c.-124T>C | upstream_gene_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7186 | c.1947C>G | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7225 | c.-77T>C | upstream_gene_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7234 | c.1995C>T | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7237 | c.-65C>T | upstream_gene_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7556 | c.255C>T | synonymous_variant | 0.19 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7601 | c.300C>G | synonymous_variant | 0.22 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7607 | c.306C>G | synonymous_variant | 0.25 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7631 | c.330G>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7637 | c.336C>G | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7652 | c.351C>T | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7658 | c.357A>G | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7664 | c.363T>C | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7667 | c.366C>T | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7670 | c.369A>G | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7676 | c.375G>C | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7679 | c.378G>C | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7683 | c.382A>C | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7694 | c.393A>G | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7697 | c.396C>G | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7715 | c.414G>C | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7727 | c.426G>C | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7728 | c.427_429delAGGinsCGT | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7763 | c.462T>G | synonymous_variant | 0.33 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7784 | c.483A>G | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7787 | c.486G>A | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7793 | c.492G>C | synonymous_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7799 | c.498A>G | synonymous_variant | 0.23 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7802 | c.501C>G | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7814 | c.513C>G | synonymous_variant | 0.23 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7823 | c.522G>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7835 | c.534A>C | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9275 | c.1974G>A | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9284 | c.1983T>C | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9299 | c.1998G>C | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9304 | p.Gly668Glu | missense_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9317 | c.2016G>C | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9332 | p.Asn677Lys | missense_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9335 | c.2034G>C | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9341 | c.2040C>G | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9345 | c.2044A>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9353 | c.2052G>C | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
Rv0010c | 13483 | p.Ala26Thr | missense_variant | 1.0 | isoniazid | Uncertain significance |
fgd1 | 491144 | p.Ala121Asp | missense_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491547 | c.765A>C | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491550 | c.768T>C | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491574 | c.792C>T | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
mshA | 575527 | c.180G>C | synonymous_variant | 0.35 | isoniazid | |
ethionamide | ||||||
mshA | 575536 | c.189T>C | synonymous_variant | 0.38 | isoniazid | |
ethionamide | ||||||
mshA | 575539 | c.192C>T | synonymous_variant | 0.39 | isoniazid | Not assoc w R - Interim |
ethionamide | Not assoc w R - Interim | |||||
mshA | 575548 | c.201C>T | synonymous_variant | 0.37 | isoniazid | |
ethionamide | ||||||
mshA | 575561 | p.Met72Val | missense_variant | 0.34 | isoniazid | |
ethionamide | ||||||
mshA | 575569 | c.222A>G | synonymous_variant | 0.38 | isoniazid | |
ethionamide | ||||||
mshA | 575575 | c.228G>A | synonymous_variant | 0.37 | isoniazid | |
ethionamide | ||||||
mshA | 575582 | p.Leu79Met | missense_variant | 0.35 | isoniazid | |
ethionamide | ||||||
mshA | 575587 | c.240C>G | synonymous_variant | 0.35 | isoniazid | |
ethionamide | ||||||
mshA | 575590 | c.243T>C | synonymous_variant | 0.34 | isoniazid | |
ethionamide | ||||||
mshA | 575593 | c.246G>C | synonymous_variant | 0.34 | isoniazid | |
ethionamide | ||||||
mshA | 575597 | p.Ile84Val | missense_variant | 0.34 | isoniazid | |
ethionamide | ||||||
mshA | 575620 | c.273G>C | synonymous_variant | 0.33 | isoniazid | |
ethionamide | ||||||
mshA | 575627 | p.Ala94Thr | missense_variant | 0.33 | isoniazid | |
ethionamide | ||||||
mshA | 575635 | c.288A>C | synonymous_variant | 0.27 | isoniazid | Not assoc w R - Interim |
ethionamide | ||||||
mshA | 575641 | c.294A>G | synonymous_variant | 0.25 | isoniazid | |
ethionamide | ||||||
mshA | 575644 | c.297G>C | synonymous_variant | 0.22 | isoniazid | |
ethionamide | ||||||
mshA | 575647 | c.300G>C | synonymous_variant | 0.22 | isoniazid | |
ethionamide | ||||||
mshA | 575659 | c.312A>G | synonymous_variant | 0.15 | isoniazid | |
ethionamide | ||||||
mshA | 575744 | p.Ala133Thr | missense_variant | 0.2 | isoniazid | Uncertain significance |
ethionamide | ||||||
mshA | 575752 | c.405G>C | synonymous_variant | 0.17 | isoniazid | |
ethionamide | ||||||
mshA | 575761 | c.414C>G | synonymous_variant | 0.16 | isoniazid | |
ethionamide | ||||||
mshA | 575764 | c.417C>G | synonymous_variant | 0.16 | isoniazid | |
ethionamide | ||||||
mshA | 575770 | c.423G>C | synonymous_variant | 0.17 | isoniazid | |
ethionamide | ||||||
mshA | 575771 | p.Val142Thr | missense_variant | 0.17 | isoniazid | |
ethionamide | ||||||
mshA | 575785 | c.438T>C | synonymous_variant | 0.16 | isoniazid | |
ethionamide | ||||||
mshA | 575800 | c.453G>T | synonymous_variant | 0.19 | isoniazid | |
ethionamide | ||||||
mshA | 575803 | c.456C>T | synonymous_variant | 0.19 | isoniazid | Not assoc w R - Interim |
ethionamide | ||||||
ccsA | 620598 | c.708C>G | synonymous_variant | 0.15 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620604 | c.714C>G | synonymous_variant | 0.15 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620605 | p.Val239Ile | missense_variant | 0.15 | kanamycin | Uncertain significance |
capreomycin | ||||||
amikacin | Uncertain significance | |||||
ccsA | 620613 | c.723C>G | synonymous_variant | 0.17 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620619 | c.729G>C | synonymous_variant | 0.18 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620625 | c.735A>C | synonymous_variant | 0.18 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620631 | c.741T>G | synonymous_variant | 0.18 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620649 | c.759A>G | synonymous_variant | 0.24 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620676 | c.786C>T | synonymous_variant | 0.3 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620694 | c.804C>G | synonymous_variant | 0.43 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620698 | p.Val270Ile | missense_variant | 0.43 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620712 | c.822G>C | synonymous_variant | 0.37 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620718 | c.828G>C | synonymous_variant | 0.35 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620721 | c.831G>C | synonymous_variant | 0.34 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620733 | c.843G>C | synonymous_variant | 0.37 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620739 | c.849A>G | synonymous_variant | 0.32 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620742 | c.852G>C | synonymous_variant | 0.33 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620748 | c.858T>C | synonymous_variant | 0.32 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620778 | c.888T>C | synonymous_variant | 0.29 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620783 | p.Ala298Val | missense_variant | 0.27 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620796 | c.906C>G | synonymous_variant | 0.25 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620802 | c.912C>G | synonymous_variant | 0.24 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620808 | c.918T>C | synonymous_variant | 0.2 | kanamycin | Not assoc w R - Interim |
capreomycin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
hadA | 731789 | c.-141A>G | upstream_gene_variant | 0.16 | isoniazid | |
nusG | 734499 | c.246G>C | synonymous_variant | 0.16 | rifampicin | |
nusG | 734508 | c.255C>G | synonymous_variant | 0.17 | rifampicin | |
nusG | 734532 | c.279A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
nusG | 734559 | c.306T>C | synonymous_variant | 0.14 | rifampicin | |
rpoB | 760070 | c.264T>G | synonymous_variant | 0.15 | rifampicin | |
rpoB | 760091 | c.285G>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 760106 | c.300G>C | synonymous_variant | 0.34 | rifampicin | |
rpoB | 760112 | c.306T>C | synonymous_variant | 0.32 | rifampicin | |
rpoB | 760115 | c.309C>T | synonymous_variant | 0.32 | rifampicin | Not assoc w R |
rpoB | 760118 | c.312T>G | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 760121 | c.315T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoB | 760130 | p.Asp108Glu | missense_variant | 0.33 | rifampicin | Uncertain significance |
rpoB | 760139 | c.333A>G | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 760142 | c.336C>G | synonymous_variant | 0.32 | rifampicin | |
rpoB | 760181 | c.375T>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 760184 | c.378A>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoB | 760196 | c.390C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 760235 | c.429T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760244 | c.438G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760283 | c.477G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760298 | c.492G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760310 | c.504G>C | synonymous_variant | 0.28 | rifampicin | |
rpoB | 760316 | c.510C>G | synonymous_variant | 0.31 | rifampicin | |
rpoB | 760328 | c.522G>C | synonymous_variant | 0.2 | rifampicin | |
rpoB | 760331 | c.525G>C | synonymous_variant | 0.2 | rifampicin | |
rpoB | 760337 | c.531C>G | synonymous_variant | 0.22 | rifampicin | |
rpoB | 760340 | c.534G>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 760357 | p.Thr184Asn | missense_variant | 0.25 | rifampicin | |
rpoB | 760361 | c.555T>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 760376 | p.Asp190Glu | missense_variant | 0.27 | rifampicin | Uncertain significance |
rpoB | 760406 | c.600G>C | synonymous_variant | 0.2 | rifampicin | |
rpoB | 760407 | p.Ser201Gly | missense_variant | 0.2 | rifampicin | Uncertain significance |
rpoB | 760415 | c.609C>T | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 760424 | c.618C>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoB | 760430 | c.624T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760454 | c.648C>G | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760460 | c.654G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 760496 | c.690G>C | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760502 | c.696C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 760508 | c.702G>C | synonymous_variant | 0.15 | rifampicin | |
rpoB | 760522 | p.Ser239Asn | missense_variant | 0.24 | rifampicin | Uncertain significance |
rpoB | 760532 | c.726T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760534 | p.Val243Ala | missense_variant | 0.15 | rifampicin | |
rpoB | 760541 | c.735G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760547 | c.741G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 760563 | p.Arg253Met | missense_variant | 0.28 | rifampicin | Uncertain significance |
rpoB | 760568 | c.762G>C | synonymous_variant | 0.27 | rifampicin | |
rpoB | 760574 | c.768G>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 760591 | p.Val262Ala | missense_variant | 0.35 | rifampicin | |
rpoB | 760611 | c.805_807delTTGinsCTC | synonymous_variant | 0.39 | rifampicin | |
rpoB | 760625 | c.819C>G | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoB | 760646 | c.840C>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 760655 | c.849A>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 760661 | c.855A>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 760670 | c.864G>C | synonymous_variant | 0.19 | rifampicin | |
rpoB | 760674 | c.868T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760679 | c.873A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760683 | c.877T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760724 | c.918T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760730 | c.924T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760796 | c.990A>G | synonymous_variant | 0.19 | rifampicin | |
rpoB | 760805 | c.999G>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 760808 | c.1002C>G | synonymous_variant | 0.16 | rifampicin | |
rpoB | 760916 | c.1110C>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760919 | c.1113C>T | synonymous_variant | 0.15 | rifampicin | |
rpoB | 760922 | c.1116G>T | synonymous_variant | 0.15 | rifampicin | |
rpoB | 760931 | c.1125C>G | synonymous_variant | 0.14 | rifampicin | |
rpoB | 760946 | c.1140A>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 760985 | c.1179G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760988 | c.1182C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760997 | c.1191G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 761261 | c.1455G>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 761264 | c.1458C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 761273 | c.1467T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 761282 | c.1476C>T | synonymous_variant | 0.17 | rifampicin | |
rpoB | 761318 | c.1512G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761327 | c.1521A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761765 | c.1959T>C | synonymous_variant | 0.24 | rifampicin | |
rpoB | 761772 | p.His656Ala | missense_variant | 0.23 | rifampicin | |
rpoB | 761778 | p.Asn658Asp | missense_variant | 0.18 | rifampicin | |
rpoB | 761792 | c.1986T>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 761813 | c.2007T>C | synonymous_variant | 0.32 | rifampicin | |
rpoB | 761834 | c.2028T>C | synonymous_variant | 0.2 | rifampicin | |
rpoB | 761847 | p.Cys681Arg | missense_variant | 0.21 | rifampicin | Uncertain significance |
rpoB | 761852 | c.2046C>G | synonymous_variant | 0.22 | rifampicin | |
rpoB | 761864 | c.2058G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 761868 | p.Asp688Gln | missense_variant | 0.22 | rifampicin | |
rpoB | 761873 | c.2067A>T | synonymous_variant | 0.22 | rifampicin | |
rpoB | 761882 | c.2076C>G | synonymous_variant | 0.21 | rifampicin | |
rpoB | 761891 | c.2085G>C | synonymous_variant | 0.17 | rifampicin | |
rpoB | 761892 | p.Ile696Val | missense_variant | 0.17 | rifampicin | |
rpoB | 761903 | c.2097T>C | synonymous_variant | 0.22 | rifampicin | |
rpoB | 761909 | c.2103T>C | synonymous_variant | 0.2 | rifampicin | |
rpoB | 761912 | c.2106T>C | synonymous_variant | 0.21 | rifampicin | |
rpoB | 761913 | p.Asp703Gln | missense_variant | 0.21 | rifampicin | |
rpoB | 761916 | p.Asp704Asn | missense_variant | 0.21 | rifampicin | |
rpoB | 761921 | c.2115C>T | synonymous_variant | 0.21 | rifampicin | |
rpoB | 761930 | c.2124G>C | synonymous_variant | 0.28 | rifampicin | |
rpoB | 761948 | c.2142G>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 761954 | c.2148C>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoB | 761999 | c.2193G>C | synonymous_variant | 0.19 | rifampicin | |
rpoB | 762008 | c.2202C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoB | 762014 | c.2208C>T | synonymous_variant | 0.18 | rifampicin | |
rpoB | 762026 | c.2220G>A | synonymous_variant | 0.14 | rifampicin | |
rpoB | 762038 | c.2232C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 762083 | c.2277T>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 762086 | c.2280G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 762962 | c.3156C>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 762995 | c.3189G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 763028 | c.3222T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R |
rpoB | 763040 | c.3234C>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 763058 | c.-312C>G | upstream_gene_variant | 0.35 | rifampicin | |
rpoB | 763070 | c.3264T>C | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoC | 763076 | c.-294C>G | upstream_gene_variant | 0.37 | rifampicin | |
rpoB | 763082 | c.3276C>T | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoC | 763103 | c.-267G>C | upstream_gene_variant | 0.29 | rifampicin | |
rpoB | 763115 | c.3309T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 763127 | c.3321G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoB | 763130 | c.3324G>A | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 763160 | c.-210G>T | upstream_gene_variant | 0.22 | rifampicin | |
rpoB | 763166 | c.3360A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 763169 | c.-201A>G | upstream_gene_variant | 0.2 | rifampicin | |
rpoC | 763181 | c.-189G>C | upstream_gene_variant | 0.19 | rifampicin | |
rpoC | 763444 | c.75T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 763447 | c.78C>T | synonymous_variant | 0.17 | rifampicin | |
rpoC | 763456 | c.87A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 763495 | c.126G>A | synonymous_variant | 0.14 | rifampicin | |
rpoC | 763576 | c.207C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 763594 | c.225C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 763621 | c.252C>T | synonymous_variant | 0.21 | rifampicin | |
rpoC | 763660 | c.291T>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 763741 | c.372C>T | synonymous_variant | 0.14 | rifampicin | |
rpoC | 763744 | c.375G>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 763891 | c.522G>C | synonymous_variant | 0.25 | rifampicin | |
rpoC | 763894 | c.525A>G | synonymous_variant | 0.26 | rifampicin | |
rpoC | 763900 | c.531G>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 763903 | c.534G>A | synonymous_variant | 0.25 | rifampicin | |
rpoC | 763921 | c.552G>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 763930 | c.561G>A | synonymous_variant | 0.22 | rifampicin | |
rpoC | 763940 | p.Ala191Thr | missense_variant | 0.15 | rifampicin | |
rpoC | 763951 | c.582G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 763960 | c.591T>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 763978 | c.609C>T | synonymous_variant | 0.18 | rifampicin | |
rpoC | 763987 | c.618C>T | synonymous_variant | 0.17 | rifampicin | |
rpoC | 763991 | p.Ile208Leu | missense_variant | 0.16 | rifampicin | |
rpoC | 764263 | c.894G>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 764266 | c.897T>C | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764764 | c.1395T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764797 | c.1428G>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 764803 | c.1434C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 764809 | c.1440C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R |
rpoC | 764815 | c.1446A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764827 | c.1458G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 764843 | p.Ala492Ser | missense_variant | 0.17 | rifampicin | |
rpoC | 764995 | c.1626C>G | synonymous_variant | 0.91 | rifampicin | Not assoc w R |
rpoC | 765454 | c.2085C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765466 | c.2097C>T | synonymous_variant | 0.21 | rifampicin | |
rpoC | 765478 | c.2109T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 765480 | p.Tyr704Phe | missense_variant | 0.22 | rifampicin | Uncertain significance |
rpoC | 765493 | c.2124G>C | synonymous_variant | 0.23 | rifampicin | |
rpoC | 765496 | c.2127C>G | synonymous_variant | 0.23 | rifampicin | |
rpoC | 765499 | c.2130C>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 765529 | c.2160C>T | synonymous_variant | 0.22 | rifampicin | |
rpoC | 765533 | p.Tyr722His | missense_variant | 0.23 | rifampicin | Uncertain significance |
rpoC | 765796 | c.2427C>T | synonymous_variant | 0.17 | rifampicin | |
rpoC | 765800 | p.Phe811Leu | missense_variant | 0.17 | rifampicin | |
rpoC | 765805 | c.2436C>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 765811 | c.2442T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765812 | c.2443C>A | synonymous_variant | 0.16 | rifampicin | |
rpoC | 765826 | c.2457T>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 765835 | c.2466C>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 765871 | c.2502T>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 765875 | p.Val836Ile | missense_variant | 0.29 | rifampicin | Uncertain significance |
rpoC | 765892 | c.2523T>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoC | 765904 | c.2535C>G | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 765937 | c.2568T>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 765946 | c.2577C>T | synonymous_variant | 0.36 | rifampicin | |
rpoC | 765947 | c.2578T>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 765961 | c.2592G>T | synonymous_variant | 0.3 | rifampicin | |
rpoC | 765962 | c.2593_2595delTTGinsCTT | synonymous_variant | 0.3 | rifampicin | |
rpoC | 765967 | c.2598C>T | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 765982 | c.2613C>T | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoC | 765994 | c.2625A>T | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoC | 766003 | c.2634G>C | synonymous_variant | 0.37 | rifampicin | |
rpoC | 766009 | c.2640G>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoC | 766010 | c.2641_2642delTCinsAG | synonymous_variant | 0.36 | rifampicin | |
rpoC | 766021 | c.2652G>C | synonymous_variant | 0.38 | rifampicin | |
rpoC | 766027 | c.2658G>C | synonymous_variant | 0.37 | rifampicin | |
rpoC | 766043 | p.Gln892Glu | missense_variant | 0.4 | rifampicin | |
rpoC | 766054 | c.2685C>T | synonymous_variant | 0.25 | rifampicin | |
rpoC | 766061 | p.Val898Asn | missense_variant | 0.21 | rifampicin | |
rpoC | 766067 | p.Glu900Thr | missense_variant | 0.21 | rifampicin | |
rpoC | 766081 | c.2712T>G | synonymous_variant | 0.21 | rifampicin | |
rpoC | 766084 | c.2715A>T | synonymous_variant | 0.21 | rifampicin | |
rpoC | 766085 | p.Pro906Ala | missense_variant | 0.21 | rifampicin | Not assoc w R |
rpoC | 766112 | p.Tyr915His | missense_variant | 0.17 | rifampicin | |
rpoC | 766129 | c.2760C>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766131 | p.Tyr921Phe | missense_variant | 0.2 | rifampicin | |
rpoC | 766146 | p.Gly926Ala | missense_variant | 0.24 | rifampicin | |
rpoC | 766164 | p.Glu932Ala | missense_variant | 0.21 | rifampicin | |
rpoC | 766167 | p.Ala933Asp | missense_variant | 0.19 | rifampicin | |
rpoC | 766270 | c.2901G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766297 | c.2928G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766299 | p.Thr977Met | missense_variant | 0.19 | rifampicin | |
rpoC | 766309 | c.2940G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 766315 | c.2946C>G | synonymous_variant | 0.21 | rifampicin | |
rpoC | 766345 | c.2976T>C | synonymous_variant | 0.35 | rifampicin | |
rpoC | 766348 | c.2979A>G | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoC | 766369 | c.3000C>G | synonymous_variant | 0.39 | rifampicin | |
rpoC | 766381 | c.3012C>T | synonymous_variant | 0.43 | rifampicin | |
rpoC | 766384 | c.3015A>G | synonymous_variant | 0.44 | rifampicin | |
rpoC | 766393 | c.3024C>G | synonymous_variant | 0.44 | rifampicin | |
rpoC | 766426 | c.3057C>T | synonymous_variant | 0.46 | rifampicin | |
rpoC | 766429 | c.3060C>G | synonymous_variant | 0.45 | rifampicin | |
rpoC | 766447 | c.3078T>C | synonymous_variant | 0.47 | rifampicin | |
rpoC | 766459 | c.3090G>C | synonymous_variant | 0.47 | rifampicin | |
rpoC | 766471 | c.3102G>C | synonymous_variant | 0.51 | rifampicin | |
rpoC | 766480 | c.3111C>T | synonymous_variant | 0.5 | rifampicin | |
rpoC | 766483 | c.3114G>C | synonymous_variant | 0.47 | rifampicin | |
rpoC | 766486 | c.3117A>G | synonymous_variant | 0.48 | rifampicin | |
rpoC | 766492 | c.3123T>G | synonymous_variant | 0.49 | rifampicin | |
rpoC | 766493 | p.Gly1042Asn | missense_variant | 0.49 | rifampicin | |
rpoC | 766516 | c.3147C>G | synonymous_variant | 0.51 | rifampicin | |
rpoC | 766517 | p.Thr1050Ser | missense_variant | 0.5 | rifampicin | |
rpoC | 766525 | c.3156G>T | synonymous_variant | 0.46 | rifampicin | |
rpoC | 766528 | c.3159T>G | synonymous_variant | 0.45 | rifampicin | |
rpoC | 766530 | p.Arg1054Gln | missense_variant | 0.45 | rifampicin | |
rpoC | 766540 | p.Asp1057Glu | missense_variant | 0.43 | rifampicin | |
rpoC | 766543 | c.3174C>T | synonymous_variant | 0.42 | rifampicin | |
rpoC | 766549 | c.3180G>C | synonymous_variant | 0.39 | rifampicin | |
rpoC | 766570 | c.3201T>C | synonymous_variant | 0.45 | rifampicin | |
rpoC | 766573 | c.3204T>G | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoC | 766582 | c.3213C>T | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoC | 766585 | c.3216T>C | synonymous_variant | 0.39 | rifampicin | |
rpoC | 766607 | p.Ile1080Leu | missense_variant | 0.44 | rifampicin | |
rpoC | 766618 | c.3249G>C | synonymous_variant | 0.4 | rifampicin | |
rpoC | 766624 | c.3255G>C | synonymous_variant | 0.38 | rifampicin | |
rpoC | 766630 | c.3261G>C | synonymous_variant | 0.38 | rifampicin | |
rpoC | 766634 | p.Phe1089Ile | missense_variant | 0.38 | rifampicin | |
rpoC | 766645 | c.3276A>G | synonymous_variant | 0.35 | rifampicin | |
rpoC | 766651 | c.3282T>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766652 | c.3283_3284delTCinsAG | synonymous_variant | 0.24 | rifampicin | |
rpoC | 766658 | p.Arg1097Gly | missense_variant | 0.26 | rifampicin | |
rpoC | 766666 | c.3297C>G | synonymous_variant | 0.29 | rifampicin | |
rpoC | 766672 | c.3303T>C | synonymous_variant | 0.29 | rifampicin | |
rpoC | 766678 | c.3309C>T | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 766690 | c.3321G>C | synonymous_variant | 0.37 | rifampicin | |
rpoC | 766694 | p.Gln1109Asp | missense_variant | 0.38 | rifampicin | |
rpoC | 766708 | c.3339A>G | synonymous_variant | 0.41 | rifampicin | |
rpoC | 766711 | c.3342C>T | synonymous_variant | 0.39 | rifampicin | Not assoc w R - Interim |
rpoC | 766720 | c.3351C>T | synonymous_variant | 0.42 | rifampicin | |
rpoC | 766726 | c.3357T>C | synonymous_variant | 0.44 | rifampicin | |
rpoC | 766732 | c.3363G>C | synonymous_variant | 0.43 | rifampicin | |
rpoC | 766738 | c.3369G>T | synonymous_variant | 0.37 | rifampicin | |
rpoC | 766747 | c.3378C>T | synonymous_variant | 0.38 | rifampicin | |
rpoC | 766750 | c.3381C>G | synonymous_variant | 0.38 | rifampicin | |
rpoC | 766753 | c.3384C>T | synonymous_variant | 0.38 | rifampicin | |
rpoC | 766765 | c.3396A>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoC | 766774 | c.3405T>C | synonymous_variant | 0.35 | rifampicin | |
rpoC | 766776 | p.Arg1136His | missense_variant | 0.4 | rifampicin | |
rpoC | 766798 | c.3429C>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 766801 | c.3432C>T | synonymous_variant | 0.23 | rifampicin | |
rpoC | 766804 | c.3435A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 766807 | c.3438T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 766837 | c.3468G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 766843 | c.3474T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 766846 | c.3477C>G | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 766858 | c.3489C>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 766861 | c.3492G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 766864 | c.3495G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766867 | c.3498C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 766876 | c.3507C>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 766882 | c.3513C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 766883 | p.Ser1172Ala | missense_variant | 0.21 | rifampicin | Uncertain significance |
rpoC | 766894 | c.3525T>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766895 | c.3526T>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 766900 | c.3531T>C | synonymous_variant | 0.2 | rifampicin | |
rpoC | 766911 | p.Ile1181Thr | missense_variant | 0.21 | rifampicin | |
rpoC | 766915 | p.Asp1182Glu | missense_variant | 0.22 | rifampicin | |
rpoC | 766918 | c.3549C>T | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 766921 | c.3552G>C | synonymous_variant | 0.22 | rifampicin | |
rpoC | 766996 | c.3627C>T | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
rpoC | 767008 | c.3639G>A | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoC | 767023 | c.3654C>T | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
mmpL5 | 775916 | c.2565T>G | synonymous_variant | 0.16 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 775940 | c.2541C>T | synonymous_variant | 0.21 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 775946 | c.2535C>G | synonymous_variant | 0.19 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 775951 | c.2530C>T | synonymous_variant | 0.18 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 775966 | p.Ala839Ser | missense_variant | 0.19 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 775975 | p.Leu836Met | missense_variant | 0.2 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 775981 | p.Leu834Met | missense_variant | 0.2 | bedaquiline | |
clofazimine | ||||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781595 | c.36T>C | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781598 | c.39G>C | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781608 | p.Ser17Ala | missense_variant | 0.17 | streptomycin | |
rpsL | 781628 | c.69T>G | synonymous_variant | 0.23 | streptomycin | |
rpsL | 781652 | c.93T>C | synonymous_variant | 0.29 | streptomycin | |
rpsL | 781655 | c.96T>C | synonymous_variant | 0.31 | streptomycin | |
rpsL | 781658 | c.99A>G | synonymous_variant | 0.31 | streptomycin | |
rpsL | 781676 | c.117C>G | synonymous_variant | 0.38 | streptomycin | |
rpsL | 781682 | c.123T>C | synonymous_variant | 0.41 | streptomycin | |
rpsL | 781709 | c.150G>C | synonymous_variant | 0.37 | streptomycin | Not assoc w R - Interim |
rpsL | 781715 | c.156T>C | synonymous_variant | 0.38 | streptomycin | |
rpsL | 781718 | c.159C>G | synonymous_variant | 0.38 | streptomycin | |
rpsL | 781728 | c.169T>C | synonymous_variant | 0.36 | streptomycin | |
rpsL | 781733 | c.174G>C | synonymous_variant | 0.37 | streptomycin | |
rpsL | 781736 | c.177T>C | synonymous_variant | 0.38 | streptomycin | |
rpsL | 781748 | c.189C>G | synonymous_variant | 0.37 | streptomycin | |
rpsL | 781751 | c.192G>C | synonymous_variant | 0.35 | streptomycin | |
rpsL | 781754 | c.195G>A | synonymous_variant | 0.35 | streptomycin | Not assoc w R - Interim |
rpsL | 781760 | c.201T>C | synonymous_variant | 0.41 | streptomycin | |
rpsL | 781766 | c.207C>T | synonymous_variant | 0.41 | streptomycin | Not assoc w R - Interim |
rpsL | 781808 | c.249C>T | synonymous_variant | 0.28 | streptomycin | |
rpsL | 781811 | c.252C>T | synonymous_variant | 0.27 | streptomycin | |
rpsL | 781814 | c.255C>T | synonymous_variant | 0.27 | streptomycin | |
rpsL | 781817 | c.258G>T | synonymous_variant | 0.3 | streptomycin | |
rpsL | 781829 | c.270G>C | synonymous_variant | 0.23 | streptomycin | |
rpsL | 781832 | c.273T>C | synonymous_variant | 0.21 | streptomycin | |
rpsL | 781835 | c.276T>C | synonymous_variant | 0.22 | streptomycin | Not assoc w R - Interim |
rpsL | 781841 | c.282C>T | synonymous_variant | 0.24 | streptomycin | |
rpsL | 781865 | c.306G>C | synonymous_variant | 0.4 | streptomycin | |
rpsL | 781868 | c.309T>C | synonymous_variant | 0.4 | streptomycin | |
rpsL | 781871 | c.312G>C | synonymous_variant | 0.42 | streptomycin | |
rpsL | 781877 | c.318T>C | synonymous_variant | 0.41 | streptomycin | |
rpsL | 781889 | c.330C>T | synonymous_variant | 0.35 | streptomycin | |
rpsL | 781892 | c.333A>G | synonymous_variant | 0.38 | streptomycin | |
rpsL | 781895 | c.336G>A | synonymous_variant | 0.36 | streptomycin | |
rpsL | 781898 | c.339A>G | synonymous_variant | 0.38 | streptomycin | |
rpsL | 781907 | c.348T>C | synonymous_variant | 0.39 | streptomycin | |
rpsL | 781916 | c.357T>C | synonymous_variant | 0.37 | streptomycin | |
rpsL | 781929 | p.Gly124Ser | missense_variant | 0.4 | streptomycin | Uncertain significance |
rplC | 800498 | c.-311G>A | upstream_gene_variant | 0.15 | linezolid | |
rplC | 800516 | c.-293G>C | upstream_gene_variant | 0.25 | linezolid | |
rplC | 800531 | c.-278T>C | upstream_gene_variant | 0.22 | linezolid | |
rplC | 800537 | c.-272C>G | upstream_gene_variant | 0.21 | linezolid | |
rplC | 800540 | c.-269T>C | upstream_gene_variant | 0.21 | linezolid | |
rplC | 800546 | c.-263T>C | upstream_gene_variant | 0.24 | linezolid | |
rplC | 800564 | c.-245C>G | upstream_gene_variant | 0.23 | linezolid | |
rplC | 800567 | c.-242A>G | upstream_gene_variant | 0.23 | linezolid | |
rplC | 800570 | c.-239C>G | upstream_gene_variant | 0.23 | linezolid | |
rplC | 800574 | c.-235_-234delGTinsAC | upstream_gene_variant | 0.23 | linezolid | |
rplC | 800579 | c.-230C>T | upstream_gene_variant | 0.22 | linezolid | |
rplC | 800594 | c.-215C>G | upstream_gene_variant | 0.24 | linezolid | |
rplC | 800597 | c.-212A>G | upstream_gene_variant | 0.24 | linezolid | |
rplC | 800600 | c.-209G>C | upstream_gene_variant | 0.25 | linezolid | |
rplC | 800603 | c.-206G>A | upstream_gene_variant | 0.27 | linezolid | |
rplC | 800612 | c.-197A>G | upstream_gene_variant | 0.26 | linezolid | |
rplC | 800618 | c.-191T>C | upstream_gene_variant | 0.28 | linezolid | |
rplC | 800633 | c.-176T>C | upstream_gene_variant | 0.31 | linezolid | |
rplC | 800654 | c.-155T>C | upstream_gene_variant | 0.28 | linezolid | |
rplC | 800693 | c.-116A>T | upstream_gene_variant | 0.21 | linezolid | |
rplC | 800715 | c.-94A>C | upstream_gene_variant | 0.19 | linezolid | |
rplC | 800720 | c.-89T>C | upstream_gene_variant | 0.19 | linezolid | |
rplC | 800723 | c.-86C>G | upstream_gene_variant | 0.2 | linezolid | |
rplC | 800738 | c.-71T>C | upstream_gene_variant | 0.19 | linezolid | |
rplC | 800753 | c.-56C>T | upstream_gene_variant | 0.19 | linezolid | |
rplC | 800780 | c.-29C>G | upstream_gene_variant | 0.2 | linezolid | |
rplC | 800844 | c.36T>C | synonymous_variant | 0.16 | linezolid | |
rplC | 800856 | c.48A>G | synonymous_variant | 0.2 | linezolid | |
rplC | 800865 | c.57A>G | synonymous_variant | 0.22 | linezolid | |
rplC | 800867 | p.Ser20Asn | missense_variant | 0.21 | linezolid | |
rplC | 800873 | p.Arg22Lys | missense_variant | 0.18 | linezolid | |
rplC | 800877 | c.69A>C | synonymous_variant | 0.18 | linezolid | |
rplC | 800880 | c.72A>G | synonymous_variant | 0.17 | linezolid | |
rplC | 800889 | c.81C>G | synonymous_variant | 0.19 | linezolid | |
rplC | 800892 | c.84G>C | synonymous_variant | 0.19 | linezolid | |
rplC | 800904 | c.96G>C | synonymous_variant | 0.17 | linezolid | |
rplC | 800913 | c.105G>C | synonymous_variant | 0.16 | linezolid | |
rplC | 800916 | c.108A>G | synonymous_variant | 0.15 | linezolid | |
fbiC | 1304580 | c.1650T>C | synonymous_variant | 0.15 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304613 | c.1683T>C | synonymous_variant | 0.21 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304625 | c.1695C>T | synonymous_variant | 0.24 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304634 | c.1704C>G | synonymous_variant | 0.22 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304640 | c.1710A>C | synonymous_variant | 0.21 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304646 | c.1716T>C | synonymous_variant | 0.23 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304661 | c.1731C>T | synonymous_variant | 0.29 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304671 | p.Val581Thr | missense_variant | 0.25 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304675 | p.Gly582Asp | missense_variant | 0.23 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304691 | c.1761G>C | synonymous_variant | 0.31 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304694 | c.1764A>C | synonymous_variant | 0.31 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304703 | c.1773C>G | synonymous_variant | 0.32 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304715 | c.1785G>T | synonymous_variant | 0.31 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304724 | c.1794A>G | synonymous_variant | 0.24 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R - Interim | |||||
fbiC | 1304727 | c.1797A>G | synonymous_variant | 0.22 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304742 | c.1812T>G | synonymous_variant | 0.19 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304748 | c.1818T>C | synonymous_variant | 0.15 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
sigE | 1364434 | p.Arg8Trp | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
sigE | 1364790 | c.378T>C | synonymous_variant | 0.31 | pyrazinamide | |
atpE | 1461050 | c.6C>T | synonymous_variant | 0.15 | bedaquiline | |
atpE | 1461056 | c.12T>A | synonymous_variant | 0.22 | bedaquiline | |
atpE | 1461065 | c.21C>T | synonymous_variant | 0.25 | bedaquiline | |
atpE | 1461071 | c.27C>A | synonymous_variant | 0.23 | bedaquiline | |
atpE | 1461086 | c.42A>C | synonymous_variant | 0.31 | bedaquiline | |
atpE | 1461089 | c.45G>C | synonymous_variant | 0.34 | bedaquiline | |
atpE | 1461101 | c.57T>C | synonymous_variant | 0.31 | bedaquiline | |
atpE | 1461104 | c.60C>T | synonymous_variant | 0.34 | bedaquiline | |
atpE | 1461107 | c.63C>G | synonymous_variant | 0.35 | bedaquiline | |
atpE | 1461132 | p.Val30Ile | missense_variant | 0.3 | bedaquiline | |
atpE | 1461147 | c.103_105delCTTinsTTG | synonymous_variant | 0.33 | bedaquiline | |
atpE | 1461153 | p.Ser37Ala | missense_variant | 0.32 | bedaquiline | Uncertain significance |
atpE | 1461159 | p.Val39Ile | missense_variant | 0.34 | bedaquiline | Uncertain significance |
atpE | 1461167 | c.123G>C | synonymous_variant | 0.35 | bedaquiline | |
atpE | 1461170 | c.126A>G | synonymous_variant | 0.35 | bedaquiline | |
atpE | 1461179 | c.135G>C | synonymous_variant | 0.32 | bedaquiline | |
atpE | 1461182 | c.138A>G | synonymous_variant | 0.32 | bedaquiline | |
atpE | 1461185 | c.141G>T | synonymous_variant | 0.31 | bedaquiline | |
atpE | 1461188 | c.144G>C | synonymous_variant | 0.31 | bedaquiline | |
atpE | 1461197 | c.153A>G | synonymous_variant | 0.26 | bedaquiline | |
atpE | 1461212 | c.168C>G | synonymous_variant | 0.25 | bedaquiline | |
atpE | 1461215 | c.171C>G | synonymous_variant | 0.23 | bedaquiline | |
atpE | 1461219 | c.175T>C | synonymous_variant | 0.23 | bedaquiline | |
atpE | 1461224 | c.180T>G | synonymous_variant | 0.21 | bedaquiline | |
atpE | 1461230 | c.186G>C | synonymous_variant | 0.2 | bedaquiline | |
atpE | 1461233 | c.189A>G | synonymous_variant | 0.19 | bedaquiline | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471986 | n.141C>T | non_coding_transcript_exon_variant | 0.26 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472445 | n.601_604delTCTC | non_coding_transcript_exon_variant | 0.51 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472451 | n.606_607insCGGG | non_coding_transcript_exon_variant | 0.55 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472460 | n.615T>C | non_coding_transcript_exon_variant | 0.49 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472461 | n.616G>C | non_coding_transcript_exon_variant | 0.49 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472463 | n.618G>C | non_coding_transcript_exon_variant | 0.5 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472464 | n.619A>G | non_coding_transcript_exon_variant | 0.52 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472973 | n.1128A>T | non_coding_transcript_exon_variant | 0.36 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrl | 1474496 | n.839C>A | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474497 | n.840G>C | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474506 | n.849C>G | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474507 | n.850G>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474753 | n.1096A>G | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474760 | n.1103A>G | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474830 | n.1173A>G | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475061 | n.1404C>T | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475202 | n.1545G>A | non_coding_transcript_exon_variant | 0.32 | capreomycin | |
linezolid | ||||||
rrl | 1475206 | n.1549C>T | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475209 | n.1552G>C | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475213 | n.1556C>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475232 | n.1575A>G | non_coding_transcript_exon_variant | 0.28 | capreomycin | |
linezolid | ||||||
rrl | 1475242 | n.1585_1586insCGCCTACT | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1475286 | n.1629T>C | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1475291 | n.1634A>C | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475297 | n.1640C>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | |
linezolid | ||||||
rrl | 1475315 | n.1658A>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475363 | n.1706C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475419 | n.1762C>T | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475429 | n.1772G>A | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475452 | n.1795C>A | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475479 | n.1822C>T | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475480 | n.1823A>G | non_coding_transcript_exon_variant | 0.42 | capreomycin | |
linezolid | ||||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.43 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475544 | n.1887A>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475545 | n.1888T>G | non_coding_transcript_exon_variant | 0.28 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475753 | n.2096C>G | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475762 | n.2105G>T | non_coding_transcript_exon_variant | 0.45 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475763 | n.2106C>T | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475764 | n.2107A>C | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475765 | n.2108A>G | non_coding_transcript_exon_variant | 0.45 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475775 | n.2118G>T | non_coding_transcript_exon_variant | 0.51 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475916 | n.2259C>T | non_coding_transcript_exon_variant | 0.56 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475988 | n.2331A>G | non_coding_transcript_exon_variant | 0.52 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1475989 | n.2332T>A | non_coding_transcript_exon_variant | 0.52 | capreomycin | |
linezolid | ||||||
rrl | 1475997 | n.2340A>T | non_coding_transcript_exon_variant | 0.5 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476030 | n.2373A>G | non_coding_transcript_exon_variant | 0.34 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476032 | n.2375C>G | non_coding_transcript_exon_variant | 0.32 | capreomycin | |
linezolid | ||||||
rrl | 1476033 | n.2376T>G | non_coding_transcript_exon_variant | 0.32 | capreomycin | |
linezolid | ||||||
rrl | 1476035 | n.2378G>C | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476044 | n.2387T>G | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476046 | n.2389G>T | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1476047 | n.2390G>T | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1476049 | n.2392C>T | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476088 | n.2431A>T | non_coding_transcript_exon_variant | 0.48 | capreomycin | |
linezolid | ||||||
rrl | 1476095 | n.2438C>T | non_coding_transcript_exon_variant | 0.47 | capreomycin | |
linezolid | ||||||
rrl | 1476103 | n.2446C>G | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476105 | n.2448G>A | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476106 | n.2449A>T | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476110 | n.2453G>C | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476115 | n.2458T>C | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476214 | n.2557G>T | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476215 | n.2558C>T | non_coding_transcript_exon_variant | 0.31 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.33 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476251 | n.2594T>G | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476256 | n.2599A>T | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476260 | n.2603A>G | non_coding_transcript_exon_variant | 0.24 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 0.19 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476297 | n.2640C>T | non_coding_transcript_exon_variant | 0.25 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476299 | n.2642C>T | non_coding_transcript_exon_variant | 0.25 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476529 | n.2872A>G | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476540 | n.2883C>T | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476583 | n.2926G>A | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.37 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
inhA | 1674471 | c.270G>C | synonymous_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1674474 | c.273G>C | synonymous_variant | 0.18 | isoniazid | |
ethionamide | ||||||
inhA | 1674480 | c.279T>C | synonymous_variant | 0.19 | isoniazid | |
ethionamide | ||||||
inhA | 1674486 | c.285T>C | synonymous_variant | 0.22 | isoniazid | |
ethionamide | ||||||
inhA | 1674489 | c.288G>C | synonymous_variant | 0.23 | isoniazid | |
ethionamide | ||||||
inhA | 1674507 | c.306G>T | synonymous_variant | 0.29 | isoniazid | |
ethionamide | ||||||
inhA | 1674542 | p.Ala114Glu | missense_variant | 0.19 | isoniazid | |
ethionamide | ||||||
inhA | 1674546 | c.345T>C | synonymous_variant | 0.19 | isoniazid | |
ethionamide | ||||||
inhA | 1674549 | c.348G>C | synonymous_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1674550 | p.Ser117Ala | missense_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1674585 | c.384T>C | synonymous_variant | 0.25 | isoniazid | |
ethionamide | ||||||
inhA | 1674589 | p.Met130Leu | missense_variant | 0.25 | isoniazid | |
ethionamide | ||||||
inhA | 1674604 | c.403C>T | synonymous_variant | 0.26 | isoniazid | |
ethionamide | ||||||
inhA | 1674624 | c.423A>T | synonymous_variant | 0.24 | isoniazid | |
ethionamide | ||||||
inhA | 1674627 | c.426T>C | synonymous_variant | 0.23 | isoniazid | |
ethionamide | ||||||
inhA | 1674628 | p.Ser143Gly | missense_variant | 0.23 | isoniazid | |
ethionamide | ||||||
inhA | 1674656 | p.Ser152Thr | missense_variant | 0.26 | isoniazid | |
ethionamide | ||||||
inhA | 1674660 | c.459G>C | synonymous_variant | 0.25 | isoniazid | |
ethionamide | ||||||
inhA | 1674669 | c.468G>C | synonymous_variant | 0.24 | isoniazid | |
ethionamide | ||||||
inhA | 1674672 | c.471C>G | synonymous_variant | 0.26 | isoniazid | |
ethionamide | ||||||
inhA | 1674687 | c.486G>C | synonymous_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1674690 | c.489C>A | synonymous_variant | 0.16 | isoniazid | Not assoc w R - Interim |
ethionamide | ||||||
inhA | 1674693 | c.492C>G | synonymous_variant | 0.16 | isoniazid | |
ethionamide | ||||||
inhA | 1674702 | c.501G>A | synonymous_variant | 0.18 | isoniazid | |
ethionamide | ||||||
inhA | 1674703 | c.502_504delTTGinsCTC | synonymous_variant | 0.18 | isoniazid | |
ethionamide | ||||||
inhA | 1674708 | c.507G>A | synonymous_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1674714 | c.513C>G | synonymous_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1674718 | c.517A>C | synonymous_variant | 0.17 | isoniazid | |
ethionamide | ||||||
inhA | 1674726 | c.525G>C | synonymous_variant | 0.22 | isoniazid | |
ethionamide | ||||||
inhA | 1674729 | c.528G>T | synonymous_variant | 0.24 | isoniazid | |
ethionamide | ||||||
inhA | 1674742 | p.Lys181Gln | missense_variant | 0.19 | isoniazid | |
ethionamide | ||||||
inhA | 1674746 | p.Tyr182Phe | missense_variant | 0.19 | isoniazid | |
ethionamide | ||||||
rpsA | 1833700 | c.159C>A | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1833772 | c.231C>T | synonymous_variant | 0.3 | pyrazinamide | |
rpsA | 1833778 | c.237C>T | synonymous_variant | 0.3 | pyrazinamide | |
rpsA | 1833781 | c.240T>G | synonymous_variant | 0.3 | pyrazinamide | |
rpsA | 1833790 | c.249T>C | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1833799 | c.258C>G | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1833811 | c.270G>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1833829 | c.288A>G | synonymous_variant | 0.27 | pyrazinamide | |
rpsA | 1833832 | c.291G>A | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1833838 | c.297G>C | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1833841 | c.300C>G | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1833847 | c.306C>G | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1833856 | c.315A>G | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1833862 | c.321G>A | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1833874 | c.333T>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1833892 | c.351G>A | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1833894 | p.Ala118Glu | missense_variant | 0.2 | pyrazinamide | |
rpsA | 1833904 | c.363G>A | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1833970 | c.429G>C | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833994 | c.453G>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834000 | c.459G>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1834021 | c.480C>T | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834069 | c.528G>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834189 | c.648G>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834483 | c.942G>A | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834609 | c.1068T>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834619 | c.1078T>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834633 | c.1092A>G | synonymous_variant | 0.25 | pyrazinamide | |
rpsA | 1834639 | c.1098T>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1834666 | c.1125G>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834667 | p.Ala376Ser | missense_variant | 0.16 | pyrazinamide | |
tsnR | 1853361 | c.-245T>C | upstream_gene_variant | 0.22 | linezolid | |
tsnR | 1853370 | c.-236_-234delGCAinsTCG | upstream_gene_variant | 0.22 | linezolid | |
tsnR | 1853384 | c.-222G>C | upstream_gene_variant | 0.24 | linezolid | |
tsnR | 1853387 | c.-219T>C | upstream_gene_variant | 0.25 | linezolid | |
tsnR | 1853390 | c.-216G>C | upstream_gene_variant | 0.27 | linezolid | |
tsnR | 1853394 | c.-212_-210delCTCinsGCG | upstream_gene_variant | 0.25 | linezolid | |
tsnR | 1853401 | c.-205A>G | upstream_gene_variant | 0.25 | linezolid | |
tsnR | 1853420 | c.-186T>G | upstream_gene_variant | 0.36 | linezolid | |
tsnR | 1853429 | c.-177G>C | upstream_gene_variant | 0.26 | linezolid | |
tsnR | 1853432 | c.-174G>C | upstream_gene_variant | 0.26 | linezolid | |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
ndh | 2102269 | c.774C>G | synonymous_variant | 0.27 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102302 | c.741G>C | synonymous_variant | 0.21 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102305 | p.Gly246Asn | missense_variant | 0.21 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102308 | c.735G>C | synonymous_variant | 0.21 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102317 | c.726A>G | synonymous_variant | 0.18 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102320 | c.723G>C | synonymous_variant | 0.18 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102328 | p.Leu239Met | missense_variant | 0.17 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102334 | p.Gln237Glu | missense_variant | 0.21 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102338 | c.705G>A | synonymous_variant | 0.21 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102344 | c.699T>C | synonymous_variant | 0.18 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102351 | p.Arg231Lys | missense_variant | 0.17 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102355 | p.Gln230Lys | missense_variant | 0.16 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102356 | c.687T>C | synonymous_variant | 0.16 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102359 | c.684C>G | synonymous_variant | 0.16 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102366 | p.Ala226Glu | missense_variant | 0.15 | isoniazid | Uncertain significance |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102392 | c.651C>A | synonymous_variant | 0.16 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2102401 | c.642T>C | synonymous_variant | 0.19 | isoniazid | Not assoc w R - Interim |
delamanid | ||||||
ethionamide | ||||||
Rv1979c | 2222854 | p.Ile104Thr | missense_variant | 1.0 | bedaquiline | Uncertain significance |
clofazimine | Uncertain significance | |||||
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
pncA | 2289061 | p.Thr61Ala | missense_variant | 1.0 | pyrazinamide | |
kasA | 2517941 | c.-174C>G | upstream_gene_variant | 0.22 | isoniazid | |
kasA | 2517965 | c.-150C>G | upstream_gene_variant | 0.19 | isoniazid | |
kasA | 2517968 | c.-147T>C | upstream_gene_variant | 0.18 | isoniazid | |
kasA | 2517974 | c.-141T>C | upstream_gene_variant | 0.17 | isoniazid | |
kasA | 2517989 | c.-126T>G | upstream_gene_variant | 0.15 | isoniazid | |
kasA | 2518732 | c.618C>G | synonymous_variant | 0.24 | isoniazid | |
kasA | 2518747 | c.633C>G | synonymous_variant | 0.23 | isoniazid | |
kasA | 2518756 | c.642G>C | synonymous_variant | 0.29 | isoniazid | |
kasA | 2518780 | p.Glu222Asp | missense_variant | 0.23 | isoniazid | |
kasA | 2518783 | c.669T>C | synonymous_variant | 0.21 | isoniazid | |
kasA | 2518785 | p.Glu224Ala | missense_variant | 0.21 | isoniazid | |
kasA | 2518787 | p.Arg225Gly | missense_variant | 0.22 | isoniazid | |
kasA | 2518792 | c.678C>G | synonymous_variant | 0.2 | isoniazid | |
kasA | 2518795 | c.681C>G | synonymous_variant | 0.2 | isoniazid | |
kasA | 2518811 | p.Asp233Asn | missense_variant | 0.2 | isoniazid | |
kasA | 2518816 | c.702C>T | synonymous_variant | 0.2 | isoniazid | |
kasA | 2518825 | c.711T>C | synonymous_variant | 0.21 | isoniazid | |
kasA | 2518843 | c.729T>C | synonymous_variant | 0.24 | isoniazid | |
kasA | 2518847 | p.Leu245Met | missense_variant | 0.22 | isoniazid | |
kasA | 2518853 | p.Leu247Ile | missense_variant | 0.23 | isoniazid | |
kasA | 2518864 | c.750G>C | synonymous_variant | 0.26 | isoniazid | |
kasA | 2518873 | c.759C>T | synonymous_variant | 0.14 | isoniazid | |
kasA | 2519194 | c.1080G>C | synonymous_variant | 0.19 | isoniazid | |
kasA | 2519195 | p.Thr361Ala | missense_variant | 0.19 | isoniazid | |
kasA | 2519203 | c.1089C>T | synonymous_variant | 0.23 | isoniazid | |
kasA | 2519224 | c.1110C>A | synonymous_variant | 0.29 | isoniazid | |
kasA | 2519227 | c.1113G>C | synonymous_variant | 0.27 | isoniazid | |
Rv2477c | 2782453 | c.1590C>T | synonymous_variant | 0.21 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782495 | c.1548C>T | synonymous_variant | 0.23 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782501 | c.1542T>G | synonymous_variant | 0.24 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782528 | c.1515G>C | synonymous_variant | 0.28 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782537 | c.1506T>C | synonymous_variant | 0.21 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782540 | c.1503T>C | synonymous_variant | 0.21 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782546 | c.1497C>G | synonymous_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782549 | c.1494T>C | synonymous_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2782555 | c.1488G>C | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782558 | c.1485T>C | synonymous_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782561 | c.1482G>C | synonymous_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782567 | c.1476C>G | synonymous_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2782576 | c.1467C>G | synonymous_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783593 | c.450T>C | synonymous_variant | 0.16 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783875 | p.Lys56Thr | missense_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783883 | c.160T>C | synonymous_variant | 0.2 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783884 | c.159T>C | synonymous_variant | 0.22 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783920 | c.123G>C | synonymous_variant | 0.33 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783938 | c.105T>C | synonymous_variant | 0.19 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783947 | c.96C>A | synonymous_variant | 0.18 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2783957 | p.Tyr29Leu | missense_variant | 0.15 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783962 | p.Ser27Asn | missense_variant | 0.15 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783967 | c.76T>C | synonymous_variant | 0.16 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783968 | p.Thr25Asn | missense_variant | 0.16 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783971 | c.72G>C | synonymous_variant | 0.16 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783992 | c.51T>C | synonymous_variant | 0.16 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | ||||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2752c | 3065046 | c.1146G>C | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
thyX | 3067661 | c.285C>G | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
thyX | 3067685 | c.261A>G | synonymous_variant | 0.25 | para-aminosalicylic_acid | |
thyX | 3067688 | c.258G>C | synonymous_variant | 0.25 | para-aminosalicylic_acid | |
thyX | 3067694 | c.252G>C | synonymous_variant | 0.19 | para-aminosalicylic_acid | |
thyX | 3067784 | c.162C>G | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
thyX | 3067788 | p.Lys53Arg | missense_variant | 0.21 | para-aminosalicylic_acid | |
thyX | 3067793 | c.153T>C | synonymous_variant | 0.21 | para-aminosalicylic_acid | |
thyA | 3073868 | p.Thr202Ala | missense_variant | 0.96 | para-aminosalicylic_acid | |
thyA | 3073977 | c.495A>G | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
Rv3236c | 3612009 | p.Ala370Thr | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | rifampicin | Not assoc w R |
bedaquiline | Uncertain significance | |||||
lpqB | 3625276 | c.-366C>G | upstream_gene_variant | 0.22 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625279 | c.-369C>G | upstream_gene_variant | 0.22 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625285 | c.-375G>C | upstream_gene_variant | 0.23 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625291 | c.-381A>G | upstream_gene_variant | 0.22 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625306 | c.-396G>C | upstream_gene_variant | 0.2 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625327 | c.-417A>G | upstream_gene_variant | 0.25 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625345 | c.-435T>C | upstream_gene_variant | 0.32 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625351 | c.1263T>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625357 | c.-447T>C | upstream_gene_variant | 0.31 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625375 | c.-465A>G | upstream_gene_variant | 0.24 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625669 | c.-759G>C | upstream_gene_variant | 0.24 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625690 | c.-782_-780delCGTinsAGG | upstream_gene_variant | 0.23 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625693 | c.-783G>C | upstream_gene_variant | 0.23 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625696 | c.-786A>G | upstream_gene_variant | 0.23 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625703 | c.-794_-793delAGinsTC | upstream_gene_variant | 0.24 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625705 | c.909C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625720 | c.894G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625729 | c.885A>G | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625735 | c.879C>A | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625747 | c.867G>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625755 | p.Ala287Thr | missense_variant | 0.39 | rifampicin | Uncertain significance |
bedaquiline | ||||||
lpqB | 3625762 | c.-852A>C | upstream_gene_variant | 0.27 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625765 | p.Ser283Gln | missense_variant | 0.27 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625806 | c.808A>C | synonymous_variant | 0.36 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625822 | c.-912C>T | upstream_gene_variant | 0.26 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627181 | c.-568T>C | upstream_gene_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627209 | c.-596G>A | upstream_gene_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627218 | c.-605G>C | upstream_gene_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627224 | c.-611G>C | upstream_gene_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627227 | c.-614T>G | upstream_gene_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627233 | c.-620T>C | upstream_gene_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627236 | c.-623T>C | upstream_gene_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627242 | c.108C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3627251 | c.-638G>C | upstream_gene_variant | 0.15 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627263 | c.-650C>G | upstream_gene_variant | 0.14 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627314 | c.-704T>C | upstream_gene_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
mtrB | 3627325 | c.-712T>C | upstream_gene_variant | 0.24 | rifampicin | |
bedaquiline | ||||||
rpoA | 3877704 | c.804G>T | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoA | 3877710 | c.798C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoA | 3877728 | c.780C>G | synonymous_variant | 0.24 | rifampicin | |
rpoA | 3877776 | c.732T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoA | 3877782 | c.726T>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoA | 3877818 | c.690A>G | synonymous_variant | 0.37 | rifampicin | Not assoc w R - Interim |
rpoA | 3877848 | c.660C>T | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoA | 3877857 | c.651G>A | synonymous_variant | 0.45 | rifampicin | |
rpoA | 3877875 | c.633T>G | synonymous_variant | 0.48 | rifampicin | |
rpoA | 3877881 | c.627G>C | synonymous_variant | 0.47 | rifampicin | |
rpoA | 3877884 | c.624G>C | synonymous_variant | 0.47 | rifampicin | |
rpoA | 3877893 | c.615C>T | synonymous_variant | 0.46 | rifampicin | Not assoc w R - Interim |
rpoA | 3877900 | p.Ser203Thr | missense_variant | 0.44 | rifampicin | |
rpoA | 3877905 | c.603A>G | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoA | 3877908 | c.600T>C | synonymous_variant | 0.45 | rifampicin | Not assoc w R - Interim |
rpoA | 3877920 | c.588G>C | synonymous_variant | 0.4 | rifampicin | Not assoc w R - Interim |
rpoA | 3877926 | c.582G>C | synonymous_variant | 0.37 | rifampicin | |
rpoA | 3877962 | c.546G>T | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoA | 3877971 | p.Asp179Glu | missense_variant | 0.3 | rifampicin | Uncertain significance |
rpoA | 3877989 | c.519A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoA | 3878001 | c.507A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoA | 3878082 | c.426T>C | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878103 | c.405A>G | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878106 | c.402G>C | synonymous_variant | 0.2 | rifampicin | |
rpoA | 3878118 | c.390T>C | synonymous_variant | 0.25 | rifampicin | |
rpoA | 3878130 | c.378C>G | synonymous_variant | 0.33 | rifampicin | |
rpoA | 3878142 | p.Gly122Glu | missense_variant | 0.33 | rifampicin | |
rpoA | 3878163 | c.345C>T | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoA | 3878187 | c.321C>G | synonymous_variant | 0.45 | rifampicin | |
rpoA | 3878193 | c.315T>C | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoA | 3878217 | c.291A>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoA | 3878247 | c.261G>C | synonymous_variant | 0.32 | rifampicin | |
rpoA | 3878256 | c.252G>C | synonymous_variant | 0.31 | rifampicin | |
rpoA | 3878271 | c.237T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoA | 3878283 | p.Glu75Asp | missense_variant | 0.27 | rifampicin | Uncertain significance |
rpoA | 3878292 | c.216T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoA | 3878298 | c.210A>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoA | 3878301 | c.207C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoA | 3878307 | c.201C>G | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3878310 | c.198G>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoA | 3878313 | c.195G>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoA | 3878322 | c.186A>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoA | 3878331 | c.177A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878346 | c.162T>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3879049 | c.-542A>C | upstream_gene_variant | 0.19 | rifampicin | |
rpoA | 3879061 | c.-554C>T | upstream_gene_variant | 0.19 | rifampicin | |
rpoA | 3879073 | c.-566A>G | upstream_gene_variant | 0.24 | rifampicin | |
rpoA | 3879078 | c.-571A>C | upstream_gene_variant | 0.24 | rifampicin | |
rpoA | 3879079 | c.-572A>C | upstream_gene_variant | 0.24 | rifampicin | |
rpoA | 3879088 | c.-581A>C | upstream_gene_variant | 0.21 | rifampicin | |
rpoA | 3879094 | c.-587T>C | upstream_gene_variant | 0.21 | rifampicin | |
rpoA | 3879136 | c.-629A>G | upstream_gene_variant | 0.21 | rifampicin | |
clpC1 | 4038287 | c.2418C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R |
clpC1 | 4038623 | c.2082A>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038640 | p.Asp689Asn | missense_variant | 0.2 | pyrazinamide | |
clpC1 | 4038647 | c.2058T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038740 | c.1965G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039589 | c.1116G>T | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039592 | c.1113G>C | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039598 | c.1107C>T | synonymous_variant | 0.27 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039604 | c.1101G>A | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039616 | c.1089G>C | synonymous_variant | 0.32 | pyrazinamide | |
clpC1 | 4039647 | p.Glu353Ala | missense_variant | 0.38 | pyrazinamide | |
clpC1 | 4039652 | c.1053G>C | synonymous_variant | 0.4 | pyrazinamide | |
clpC1 | 4039670 | c.1035G>C | synonymous_variant | 0.34 | pyrazinamide | |
clpC1 | 4039724 | c.981A>G | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4039730 | c.975C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039733 | c.972G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039739 | c.966C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039742 | c.963C>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039898 | c.807C>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039904 | c.801A>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039931 | c.774T>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039937 | c.768G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039946 | c.759A>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039949 | c.756G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039952 | c.753T>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039955 | c.750G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039958 | c.747G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039991 | c.714G>A | synonymous_variant | 0.73 | pyrazinamide | Not assoc w R |
clpC1 | 4039994 | p.Glu237Asp | missense_variant | 0.27 | pyrazinamide | |
clpC1 | 4040009 | c.696C>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4040015 | c.690G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040018 | c.687G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040021 | c.684A>C | synonymous_variant | 0.16 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040024 | c.681A>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4040033 | c.672G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4040228 | c.477G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040249 | c.456A>G | synonymous_variant | 0.47 | pyrazinamide | |
clpC1 | 4040252 | c.453C>G | synonymous_variant | 0.48 | pyrazinamide | |
clpC1 | 4040257 | p.Ala150Ser | missense_variant | 0.45 | pyrazinamide | |
clpC1 | 4040267 | c.438A>G | synonymous_variant | 0.41 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040277 | c.427_428delTCinsAG | synonymous_variant | 0.35 | pyrazinamide | |
clpC1 | 4040279 | c.426C>G | synonymous_variant | 0.36 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040444 | c.261C>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4040450 | c.255A>G | synonymous_variant | 0.16 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040459 | c.246C>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040465 | c.240T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4040480 | c.225T>C | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040486 | c.219G>A | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040522 | c.183T>C | synonymous_variant | 0.15 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040531 | c.174T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4040644 | c.61A>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4040648 | c.57G>A | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4040654 | c.51G>A | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4040657 | c.48T>G | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040693 | c.12A>T | synonymous_variant | 0.22 | pyrazinamide | |
panD | 4044147 | c.135C>G | synonymous_variant | 0.16 | pyrazinamide | |
panD | 4044150 | c.132A>C | synonymous_variant | 0.16 | pyrazinamide | |
panD | 4044162 | c.120A>G | synonymous_variant | 0.22 | pyrazinamide | |
panD | 4044189 | c.93C>T | synonymous_variant | 0.15 | pyrazinamide | |
panD | 4044195 | c.87T>C | synonymous_variant | 0.17 | pyrazinamide | |
glpK | 4139672 | c.84C>G | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
embC | 4240736 | p.Ser292Ala | missense_variant | 0.16 | ethambutol | |
embC | 4240765 | c.903C>G | synonymous_variant | 0.24 | ethambutol | |
embC | 4240780 | c.918T>C | synonymous_variant | 0.23 | ethambutol | |
embC | 4240783 | c.921G>C | synonymous_variant | 0.21 | ethambutol | |
embC | 4240789 | c.927T>C | synonymous_variant | 0.19 | ethambutol | |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
ubiA | 4269144 | c.690C>G | synonymous_variant | 0.23 | ethambutol | Not assoc w R - Interim |
ubiA | 4269164 | p.Leu224Met | missense_variant | 0.24 | ethambutol | |
aftB | 4269171 | c.-335C>G | upstream_gene_variant | 0.25 | ethambutol | |
aftB | 4269183 | c.-347T>C | upstream_gene_variant | 0.23 | ethambutol | |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
gid | 4408156 | p.Leu16Arg | missense_variant | 1.0 | streptomycin | Not assoc w R |