TB-Profiler result

Run: ERR11465352
Summary

Run ID: ERR11465352

Sample name:

Date: 2024-04-14T13:42:06.556796

Number of reads: 2213184

Percentage reads mapped: 82.69

Median coverage: 50.0

Strain: lineage4.3.4.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 1.0
lineage4.3.4.1 Euro-American (LAM) RD174 1.0
lineage4 Euro-American None 1.0
lineage4.3.4 Euro-American (LAM) RD174 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1011 c.1011C>G synonymous_variant 0.15 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.15 isoniazid
dnaA 1035 c.1035A>G synonymous_variant 0.2 isoniazid
dnaA 1038 c.1038A>C synonymous_variant 0.2 isoniazid
dnaA 1047 p.Glu349Asp missense_variant 0.21 isoniazid
dnaA 1055 p.Ala352Asp missense_variant 0.21 isoniazid
dnaA 1065 c.1065C>T synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1068 c.1068T>C synonymous_variant 0.21 isoniazid
dnaA 1077 c.1077A>G synonymous_variant 0.21 isoniazid
dnaA 1098 c.1098A>G synonymous_variant 0.16 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.14 isoniazid
gyrA 6592 c.-710C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6595 c.1356G>A synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6869 c.-433T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6896 p.Arg553Lys missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 7120 c.-182T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 7145 c.1906_1908delGTGinsAC frameshift_variant&missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7162 c.-140C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7177 c.-125G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7225 c.-77T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7234 c.1995C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7237 c.-65C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7556 c.255C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7601 c.300C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7631 c.330G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7667 c.366C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7679 c.378G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7727 c.426G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 7763 c.462T>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7802 c.501C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7814 c.513C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7823 c.522G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7835 c.534A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9299 c.1998G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9317 c.2016G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9332 p.Asn677Lys missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9335 c.2034G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9341 c.2040C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9353 c.2052G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
Rv0010c 13483 p.Ala26Thr missense_variant 1.0 isoniazid Uncertain significance
fgd1 491144 p.Ala121Asp missense_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491547 c.765A>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491550 c.768T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491574 c.792C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
mshA 575527 c.180G>C synonymous_variant 0.35 ethionamide
isoniazid
mshA 575536 c.189T>C synonymous_variant 0.38 ethionamide
isoniazid
mshA 575539 c.192C>T synonymous_variant 0.39 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575548 c.201C>T synonymous_variant 0.37 ethionamide
isoniazid
mshA 575561 c.214_216delATGinsGC frameshift_variant&missense_variant 0.34 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575569 c.222A>G synonymous_variant 0.38 ethionamide
isoniazid
mshA 575575 c.228G>A synonymous_variant 0.37 ethionamide
isoniazid
mshA 575582 p.Leu79Met missense_variant 0.35 ethionamide
isoniazid
mshA 575587 c.240C>G synonymous_variant 0.35 ethionamide
isoniazid
mshA 575590 c.243T>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575593 c.246G>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575597 p.Ile84Val missense_variant 0.34 ethionamide
isoniazid
mshA 575620 c.273G>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575627 c.280_282delGCAinsAG frameshift_variant&missense_variant 0.33 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575635 c.288A>C synonymous_variant 0.27 ethionamide
isoniazid Not assoc w R - Interim
mshA 575641 c.294A>G synonymous_variant 0.25 ethionamide
isoniazid
mshA 575644 c.297G>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575647 c.300G>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.15 ethionamide
isoniazid
mshA 575744 p.Ala133Thr missense_variant 0.2 ethionamide
isoniazid Uncertain significance
mshA 575752 c.405G>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575761 c.414C>G synonymous_variant 0.16 ethionamide
isoniazid
mshA 575764 c.417C>G synonymous_variant 0.16 ethionamide
isoniazid
mshA 575770 c.423G>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575771 p.Val142Thr missense_variant 0.17 ethionamide
isoniazid
mshA 575785 c.438T>C synonymous_variant 0.16 ethionamide
isoniazid
mshA 575800 c.453G>T synonymous_variant 0.19 ethionamide
isoniazid
mshA 575803 c.456C>T synonymous_variant 0.19 ethionamide
isoniazid Not assoc w R - Interim
ccsA 620598 c.708C>G synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620604 c.714C>G synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620605 p.Val239Ile missense_variant 0.15 capreomycin
amikacin Uncertain significance
kanamycin Uncertain significance
ccsA 620613 c.723C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620619 c.729G>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620625 c.735A>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620631 c.741T>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620649 c.759A>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620676 c.786C>T synonymous_variant 0.3 capreomycin
amikacin
kanamycin
ccsA 620694 c.804C>G synonymous_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620698 p.Val270Ile missense_variant 0.43 capreomycin
amikacin
kanamycin
ccsA 620712 c.822G>C synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.35 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.34 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.37 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620742 c.852G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620783 p.Ala298Val missense_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620796 c.906C>G synonymous_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 620802 c.912C>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620808 c.918T>C synonymous_variant 0.2 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
hadA 731789 c.-141A>G upstream_gene_variant 0.16 isoniazid
nusG 734499 c.246G>C synonymous_variant 0.16 rifampicin
nusG 734508 c.255C>G synonymous_variant 0.17 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.14 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.15 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760106 c.300G>C synonymous_variant 0.34 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.32 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.32 rifampicin Not assoc w R
rpoB 760118 c.312T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.33 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.32 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.28 rifampicin
rpoB 760316 c.510C>G synonymous_variant 0.31 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.2 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.2 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.22 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760357 p.Thr184Asn missense_variant 0.25 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.27 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.2 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.2 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760454 c.648C>G synonymous_variant 0.17 rifampicin
rpoB 760460 c.654G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760496 c.690G>C synonymous_variant 0.17 rifampicin
rpoB 760502 c.696C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760508 c.702G>C synonymous_variant 0.15 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.24 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760534 p.Val243Ala missense_variant 0.15 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.28 rifampicin Uncertain significance
rpoB 760568 c.762G>C synonymous_variant 0.27 rifampicin
rpoB 760574 c.768G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760591 p.Val262Ala missense_variant 0.35 rifampicin
rpoB 760611 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.39 rifampicin
rpoB 760625 c.819C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.19 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760796 c.990A>G synonymous_variant 0.19 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.18 rifampicin
rpoB 760808 c.1002C>G synonymous_variant 0.16 rifampicin
rpoB 760916 c.1110C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>T synonymous_variant 0.15 rifampicin
rpoB 760922 c.1116G>T synonymous_variant 0.15 rifampicin
rpoB 760931 c.1125C>G synonymous_variant 0.14 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.17 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761765 c.1959T>C synonymous_variant 0.24 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.23 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.18 rifampicin
rpoB 761792 c.1986T>C synonymous_variant 0.16 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.32 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.2 rifampicin
rpoB 761847 c.2041_2043delTGCinsCT frameshift_variant&missense_variant 0.21 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.22 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761868 c.2062_2064delGACinsCG frameshift_variant&missense_variant 0.22 rifampicin
rpoB 761873 c.2067A>T synonymous_variant 0.22 rifampicin
rpoB 761882 c.2076C>G synonymous_variant 0.21 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.17 rifampicin
rpoB 761892 p.Ile696Val missense_variant 0.17 rifampicin
rpoB 761903 c.2097T>C synonymous_variant 0.22 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.2 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.21 rifampicin
rpoB 761913 c.2107_2109delGACinsCG frameshift_variant&missense_variant 0.21 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.21 rifampicin
rpoB 761921 c.2115C>T synonymous_variant 0.21 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.28 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.19 rifampicin
rpoB 762008 c.2202C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.18 rifampicin
rpoB 762026 c.2220G>A synonymous_variant 0.14 rifampicin
rpoB 762038 c.2232C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.25 rifampicin Not assoc w R
rpoB 763040 c.3234C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763058 c.-312C>G upstream_gene_variant 0.35 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.37 rifampicin
rpoB 763082 c.3276C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.29 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763130 c.3324G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763160 c.-210G>T upstream_gene_variant 0.22 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.2 rifampicin
rpoC 763181 c.-189G>C upstream_gene_variant 0.19 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763447 c.78C>T synonymous_variant 0.17 rifampicin
rpoC 763456 c.87A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763495 c.126G>A synonymous_variant 0.14 rifampicin
rpoC 763576 c.207C>G synonymous_variant 0.16 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763621 c.252C>T synonymous_variant 0.21 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763741 c.372C>T synonymous_variant 0.14 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.15 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.25 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.26 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763903 c.534G>A synonymous_variant 0.25 rifampicin
rpoC 763921 c.552G>C synonymous_variant 0.22 rifampicin
rpoC 763930 c.561G>A synonymous_variant 0.22 rifampicin
rpoC 763940 p.Ala191Thr missense_variant 0.15 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763978 c.609C>T synonymous_variant 0.18 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.17 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.16 rifampicin
rpoC 764263 c.894G>C synonymous_variant 0.2 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.21 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764797 c.1428G>C synonymous_variant 0.2 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.2 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764843 p.Ala492Ser missense_variant 0.17 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 0.91 rifampicin Not assoc w R
rpoC 765454 c.2085C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765466 c.2097C>T synonymous_variant 0.21 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765480 p.Tyr704Phe missense_variant 0.22 rifampicin Uncertain significance
rpoC 765493 c.2124G>C synonymous_variant 0.23 rifampicin
rpoC 765496 c.2127C>G synonymous_variant 0.23 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.22 rifampicin
rpoC 765533 p.Tyr722His missense_variant 0.23 rifampicin Uncertain significance
rpoC 765796 c.2427C>T synonymous_variant 0.17 rifampicin
rpoC 765800 p.Phe811Leu missense_variant 0.17 rifampicin
rpoC 765805 c.2436C>G synonymous_variant 0.17 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765812 c.2443C>A synonymous_variant 0.16 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.29 rifampicin Uncertain significance
rpoC 765892 c.2523T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765904 c.2535C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.36 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765961 c.2592G>T synonymous_variant 0.3 rifampicin
rpoC 765962 c.2593_2595delTTGinsCT frameshift_variant&synonymous_variant 0.3 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766003 c.2634G>C synonymous_variant 0.37 rifampicin
rpoC 766009 c.2640G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.36 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.38 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.37 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.4 rifampicin
rpoC 766054 c.2685C>T synonymous_variant 0.25 rifampicin
rpoC 766061 p.Val898Asn missense_variant 0.21 rifampicin
rpoC 766067 p.Glu900Thr missense_variant 0.21 rifampicin
rpoC 766081 c.2712T>G synonymous_variant 0.21 rifampicin
rpoC 766084 c.2715A>T synonymous_variant 0.21 rifampicin
rpoC 766085 p.Pro906Ala missense_variant 0.21 rifampicin Not assoc w R
rpoC 766112 p.Tyr915His missense_variant 0.17 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.18 rifampicin
rpoC 766131 p.Tyr921Phe missense_variant 0.2 rifampicin
rpoC 766146 p.Gly926Ala missense_variant 0.24 rifampicin
rpoC 766164 p.Glu932Ala missense_variant 0.21 rifampicin
rpoC 766167 p.Ala933Asp missense_variant 0.19 rifampicin
rpoC 766270 c.2901G>C synonymous_variant 0.19 rifampicin
rpoC 766297 c.2928G>C synonymous_variant 0.19 rifampicin
rpoC 766299 p.Thr977Met missense_variant 0.19 rifampicin
rpoC 766309 c.2940G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766315 c.2946C>G synonymous_variant 0.21 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.35 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766369 c.3000C>G synonymous_variant 0.39 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.43 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.44 rifampicin
rpoC 766393 c.3024C>G synonymous_variant 0.44 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.46 rifampicin
rpoC 766429 c.3060C>G synonymous_variant 0.45 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.47 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 0.47 rifampicin
rpoC 766471 c.3102G>C synonymous_variant 0.51 rifampicin
rpoC 766480 c.3111C>T synonymous_variant 0.5 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.47 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.48 rifampicin
rpoC 766492 c.3123T>G synonymous_variant 0.49 rifampicin
rpoC 766493 p.Gly1042Asn missense_variant 0.49 rifampicin
rpoC 766516 c.3147C>G synonymous_variant 0.51 rifampicin
rpoC 766517 p.Thr1050Ser missense_variant 0.5 rifampicin
rpoC 766525 c.3156G>T synonymous_variant 0.46 rifampicin
rpoC 766528 c.3159T>G synonymous_variant 0.45 rifampicin
rpoC 766530 p.Arg1054Gln missense_variant 0.45 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.43 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.42 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.39 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.45 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766582 c.3213C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.39 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.44 rifampicin
rpoC 766618 c.3249G>C synonymous_variant 0.4 rifampicin
rpoC 766624 c.3255G>C synonymous_variant 0.38 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.38 rifampicin
rpoC 766634 p.Phe1089Ile missense_variant 0.38 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.35 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.24 rifampicin
rpoC 766652 c.3283_3284delTCinsAG synonymous_variant 0.24 rifampicin
rpoC 766658 c.3289_3291delCGGinsGC frameshift_variant&missense_variant 0.26 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.29 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.29 rifampicin
rpoC 766678 c.3309C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766690 c.3321G>C synonymous_variant 0.37 rifampicin
rpoC 766694 c.3325_3327delCAGinsGC frameshift_variant&missense_variant 0.38 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.41 rifampicin
rpoC 766711 c.3342C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766720 c.3351C>T synonymous_variant 0.42 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.44 rifampicin
rpoC 766732 c.3363G>C synonymous_variant 0.43 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.37 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.38 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.38 rifampicin
rpoC 766753 c.3384C>T synonymous_variant 0.38 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.35 rifampicin
rpoC 766776 p.Arg1136His missense_variant 0.4 rifampicin
rpoC 766798 c.3429C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766801 c.3432C>T synonymous_variant 0.23 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766807 c.3438T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766846 c.3477C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.17 rifampicin
rpoC 766867 c.3498C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766876 c.3507C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766883 p.Ser1172Ala missense_variant 0.21 rifampicin Uncertain significance
rpoC 766894 c.3525T>C synonymous_variant 0.19 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.19 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.2 rifampicin
rpoC 766911 p.Ile1181Thr missense_variant 0.21 rifampicin
rpoC 766915 p.Asp1182Glu missense_variant 0.22 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766921 c.3552G>C synonymous_variant 0.22 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775916 c.2565T>G synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 775940 c.2541C>T synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 775946 c.2535C>G synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 775951 c.2530C>T synonymous_variant 0.18 clofazimine
bedaquiline
mmpL5 775966 p.Ala839Ser missense_variant 0.19 clofazimine
bedaquiline
mmpL5 775975 p.Leu836Met missense_variant 0.2 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.2 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.17 streptomycin
rpsL 781598 c.39G>C synonymous_variant 0.17 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.17 streptomycin
rpsL 781628 c.69T>G synonymous_variant 0.23 streptomycin
rpsL 781652 c.93T>C synonymous_variant 0.29 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.31 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.31 streptomycin
rpsL 781676 c.117C>G synonymous_variant 0.38 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.41 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.37 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.38 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.38 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.36 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.37 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.38 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.37 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.35 streptomycin
rpsL 781754 c.195G>A synonymous_variant 0.35 streptomycin Not assoc w R - Interim
rpsL 781760 c.201T>C synonymous_variant 0.41 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.41 streptomycin Not assoc w R - Interim
rpsL 781808 c.249C>T synonymous_variant 0.28 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.27 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.27 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.3 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.23 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.21 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.22 streptomycin Not assoc w R - Interim
rpsL 781841 c.282C>T synonymous_variant 0.24 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.4 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.4 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.42 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.41 streptomycin
rpsL 781889 c.330C>T synonymous_variant 0.35 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.38 streptomycin
rpsL 781895 c.336G>A synonymous_variant 0.36 streptomycin
rpsL 781898 c.339A>G synonymous_variant 0.38 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.39 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.37 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.4 streptomycin Uncertain significance
rplC 800498 c.-311G>A upstream_gene_variant 0.15 linezolid
rplC 800516 c.-293G>C upstream_gene_variant 0.25 linezolid
rplC 800531 c.-278T>C upstream_gene_variant 0.22 linezolid
rplC 800537 c.-272C>G upstream_gene_variant 0.21 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.21 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.24 linezolid
rplC 800564 c.-245C>G upstream_gene_variant 0.23 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.23 linezolid
rplC 800570 c.-239C>G upstream_gene_variant 0.23 linezolid
rplC 800574 c.-235_-234delGTinsAC upstream_gene_variant 0.23 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.22 linezolid
rplC 800594 c.-215C>G upstream_gene_variant 0.24 linezolid
rplC 800597 c.-212A>G upstream_gene_variant 0.24 linezolid
rplC 800600 c.-209G>C upstream_gene_variant 0.25 linezolid
rplC 800603 c.-206G>A upstream_gene_variant 0.27 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.26 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.28 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.31 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.28 linezolid
rplC 800693 c.-116A>T upstream_gene_variant 0.21 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.19 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.19 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.2 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.19 linezolid
rplC 800753 c.-56C>T upstream_gene_variant 0.19 linezolid
rplC 800780 c.-29C>G upstream_gene_variant 0.2 linezolid
rplC 800844 c.36T>C synonymous_variant 0.16 linezolid
rplC 800856 c.48A>G synonymous_variant 0.2 linezolid
rplC 800865 c.57A>G synonymous_variant 0.22 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.21 linezolid
rplC 800873 p.Arg22Lys missense_variant 0.18 linezolid
rplC 800877 c.69A>C synonymous_variant 0.18 linezolid
rplC 800880 c.72A>G synonymous_variant 0.17 linezolid
rplC 800889 c.81C>G synonymous_variant 0.19 linezolid
rplC 800892 c.84G>C synonymous_variant 0.19 linezolid
rplC 800904 c.96G>C synonymous_variant 0.17 linezolid
rplC 800913 c.105G>C synonymous_variant 0.16 linezolid
rplC 800916 c.108A>G synonymous_variant 0.15 linezolid
fbiC 1304580 c.1650T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304625 c.1695C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304661 c.1731C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Asp missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
sigE 1364434 p.Arg8Trp missense_variant 1.0 pyrazinamide Not assoc w R
sigE 1364790 c.378T>C synonymous_variant 0.31 pyrazinamide
atpE 1461050 c.6C>T synonymous_variant 0.15 bedaquiline
atpE 1461056 c.12T>A synonymous_variant 0.22 bedaquiline
atpE 1461065 c.21C>T synonymous_variant 0.25 bedaquiline
atpE 1461071 c.27C>A synonymous_variant 0.23 bedaquiline
atpE 1461086 c.42A>C synonymous_variant 0.31 bedaquiline
atpE 1461089 c.45G>C synonymous_variant 0.34 bedaquiline
atpE 1461101 c.57T>C synonymous_variant 0.31 bedaquiline
atpE 1461104 c.60C>T synonymous_variant 0.34 bedaquiline
atpE 1461107 c.63C>G synonymous_variant 0.35 bedaquiline
atpE 1461132 p.Val30Ile missense_variant 0.3 bedaquiline
atpE 1461147 c.103_105delCTTinsTG frameshift_variant&missense_variant 0.33 bedaquiline
atpE 1461153 p.Ser37Ala missense_variant 0.32 bedaquiline Uncertain significance
atpE 1461159 p.Val39Ile missense_variant 0.34 bedaquiline Uncertain significance
atpE 1461167 c.123G>C synonymous_variant 0.35 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.35 bedaquiline
atpE 1461179 c.135G>C synonymous_variant 0.32 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.32 bedaquiline
atpE 1461185 c.141G>T synonymous_variant 0.31 bedaquiline
atpE 1461188 c.144G>C synonymous_variant 0.31 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.26 bedaquiline
atpE 1461212 c.168C>G synonymous_variant 0.25 bedaquiline
atpE 1461215 c.171C>G synonymous_variant 0.23 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.23 bedaquiline
atpE 1461224 c.180T>G synonymous_variant 0.21 bedaquiline
atpE 1461230 c.186G>C synonymous_variant 0.2 bedaquiline
atpE 1461233 c.189A>G synonymous_variant 0.19 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472445 n.601_604delTCTC non_coding_transcript_exon_variant 0.51 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472451 n.606_607insCGGG non_coding_transcript_exon_variant 0.55 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472460 n.615T>C non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472461 n.616G>C non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472463 n.618G>C non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.36 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475202 n.1545G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475232 n.1575A>G non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475242 n.1585_1586insCGCCTACT non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475286 n.1629T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475297 n.1640C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>G non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.52 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475989 n.2332T>A non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>T non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476095 n.2438C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.24 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674471 c.270G>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674474 c.273G>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674480 c.279T>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674486 c.285T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674489 c.288G>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674507 c.306G>T synonymous_variant 0.29 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.19 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674550 p.Ser117Ala missense_variant 0.17 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.25 ethionamide
isoniazid
inhA 1674604 c.403C>T synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674624 c.423A>T synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674628 p.Ser143Gly missense_variant 0.23 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.26 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674669 c.468G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674672 c.471C>G synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674687 c.486G>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674690 c.489C>A synonymous_variant 0.16 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674693 c.492C>G synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674702 c.501G>A synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674703 c.502_504delTTGinsCC frameshift_variant&missense_variant 0.18 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674714 c.513C>G synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674726 c.525G>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674729 c.528G>T synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674742 p.Lys181Gln missense_variant 0.19 ethionamide
isoniazid
inhA 1674746 p.Tyr182Phe missense_variant 0.19 ethionamide
isoniazid
rpsA 1833700 c.159C>A synonymous_variant 0.15 pyrazinamide
rpsA 1833772 c.231C>T synonymous_variant 0.3 pyrazinamide
rpsA 1833778 c.237C>T synonymous_variant 0.3 pyrazinamide
rpsA 1833781 c.240T>G synonymous_variant 0.3 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.25 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.25 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.24 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833862 c.321G>A synonymous_variant 0.19 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.21 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.21 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.2 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.21 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.18 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.16 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.16 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.22 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.22 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.24 linezolid
tsnR 1853387 c.-219T>C upstream_gene_variant 0.25 linezolid
tsnR 1853390 c.-216G>C upstream_gene_variant 0.27 linezolid
tsnR 1853394 c.-212_-210delCTCinsGCG upstream_gene_variant 0.25 linezolid
tsnR 1853401 c.-205A>G upstream_gene_variant 0.25 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.36 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.26 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.26 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2102269 c.774C>G synonymous_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102302 c.741G>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102305 p.Gly246Asn missense_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102308 c.735G>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102317 c.726A>G synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102320 c.723G>C synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102328 p.Leu239Met missense_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102334 p.Gln237Glu missense_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102338 c.705G>A synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2102344 c.699T>C synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102351 p.Arg231Lys missense_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102355 p.Gln230Lys missense_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2102356 c.687T>C synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2102359 c.684C>G synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2102366 p.Ala226Glu missense_variant 0.15 ethionamide
delamanid
isoniazid Uncertain significance
ndh 2102392 c.651C>A synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2102401 c.642T>C synonymous_variant 0.19 ethionamide
delamanid
isoniazid Not assoc w R - Interim
Rv1979c 2222854 p.Ile104Thr missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289061 p.Thr61Ala missense_variant 1.0 pyrazinamide
kasA 2517941 c.-174C>G upstream_gene_variant 0.22 isoniazid
kasA 2517965 c.-150C>G upstream_gene_variant 0.19 isoniazid
kasA 2517968 c.-147T>C upstream_gene_variant 0.18 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.17 isoniazid
kasA 2517989 c.-126T>G upstream_gene_variant 0.15 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.24 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.23 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.29 isoniazid
kasA 2518780 p.Glu222Asp missense_variant 0.23 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.21 isoniazid
kasA 2518785 p.Glu224Ala missense_variant 0.21 isoniazid
kasA 2518787 p.Arg225Gly missense_variant 0.22 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.2 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.2 isoniazid
kasA 2518811 p.Asp233Asn missense_variant 0.2 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.2 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.21 isoniazid
kasA 2518843 c.729T>C synonymous_variant 0.24 isoniazid
kasA 2518847 p.Leu245Met missense_variant 0.22 isoniazid
kasA 2518853 p.Leu247Ile missense_variant 0.23 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.26 isoniazid
kasA 2518873 c.759C>T synonymous_variant 0.14 isoniazid
kasA 2519194 c.1080G>C synonymous_variant 0.19 isoniazid
kasA 2519195 p.Thr361Ala missense_variant 0.19 isoniazid
kasA 2519203 c.1089C>T synonymous_variant 0.23 isoniazid
kasA 2519224 c.1110C>A synonymous_variant 0.29 isoniazid
kasA 2519227 c.1113G>C synonymous_variant 0.27 isoniazid
Rv2477c 2782453 c.1590C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782495 c.1548C>T synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782501 c.1542T>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782537 c.1506T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782546 c.1497C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782555 c.1488G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782576 c.1467C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783875 p.Lys56Thr missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783947 c.96C>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783957 p.Tyr29Leu missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783962 p.Ser27Asn missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783967 c.76T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783968 p.Thr25Asn missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2752c 3065046 c.1146G>C synonymous_variant 0.19 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067661 c.285C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067784 c.162C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067788 p.Lys53Arg missense_variant 0.21 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073868 p.Thr202Ala missense_variant 0.96 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.17 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0 pyrazinamide Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625276 c.-366C>G upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625279 c.-369C>G upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625285 c.-375G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625291 c.-381A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
lpqB 3625306 c.-396G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625327 c.-417A>G upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625345 c.-435T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3625351 c.1263T>C synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625357 c.-447T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625375 c.-465A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625690 c.922_924delCGTinsAG frameshift_variant&missense_variant 0.23 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3625693 c.-783G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625703 c.-794_-793delAGinsTC upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625720 c.894G>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625747 c.867G>C synonymous_variant 0.38 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.39 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625765 p.Ser283Gln missense_variant 0.27 bedaquiline
rifampicin
mtrB 3625806 c.808A>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625822 c.-912C>T upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627209 c.-596G>A upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627218 c.-605G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627224 c.-611G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627227 c.-614T>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627233 c.-620T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627251 c.-638G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627263 c.-650C>G upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3627314 c.-704T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627325 c.-712T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
rpoA 3877704 c.804G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877710 c.798C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.24 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.45 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.48 rifampicin
rpoA 3877881 c.627G>C synonymous_variant 0.47 rifampicin
rpoA 3877884 c.624G>C synonymous_variant 0.47 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.44 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.37 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.3 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>C synonymous_variant 0.19 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.19 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.2 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.25 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.33 rifampicin
rpoA 3878142 p.Gly122Glu missense_variant 0.33 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.45 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.32 rifampicin
rpoA 3878256 c.252G>C synonymous_variant 0.31 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.27 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878307 c.201C>G synonymous_variant 0.23 rifampicin
rpoA 3878310 c.198G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.15 rifampicin
rpoA 3879049 c.-542A>C upstream_gene_variant 0.19 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.19 rifampicin
rpoA 3879073 c.-566A>G upstream_gene_variant 0.24 rifampicin
rpoA 3879078 c.-571A>C upstream_gene_variant 0.24 rifampicin
rpoA 3879079 c.-572A>C upstream_gene_variant 0.24 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.21 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.21 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.21 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
clpC1 4038623 c.2082A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.2 pyrazinamide
clpC1 4038647 c.2058T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039589 c.1116G>T synonymous_variant 0.23 pyrazinamide
clpC1 4039592 c.1113G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039598 c.1107C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039604 c.1101G>A synonymous_variant 0.26 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039647 p.Glu353Ala missense_variant 0.38 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.34 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039730 c.975C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039991 c.714G>A synonymous_variant 0.73 pyrazinamide Not assoc w R
clpC1 4039994 p.Glu237Asp missense_variant 0.27 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.16 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040228 c.477G>C synonymous_variant 0.17 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.47 pyrazinamide
clpC1 4040252 c.453C>G synonymous_variant 0.48 pyrazinamide
clpC1 4040257 p.Ala150Ser missense_variant 0.45 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040277 c.427_428delTCinsAG synonymous_variant 0.35 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4040444 c.261C>G synonymous_variant 0.14 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040486 c.219G>A synonymous_variant 0.17 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040531 c.174T>C synonymous_variant 0.15 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.18 pyrazinamide
clpC1 4040648 c.57G>A synonymous_variant 0.17 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.21 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040693 c.12A>T synonymous_variant 0.22 pyrazinamide
panD 4044147 c.135C>G synonymous_variant 0.16 pyrazinamide
panD 4044150 c.132A>C synonymous_variant 0.16 pyrazinamide
panD 4044162 c.120A>G synonymous_variant 0.22 pyrazinamide
panD 4044189 c.93C>T synonymous_variant 0.15 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.17 pyrazinamide
glpK 4139672 c.84C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240736 p.Ser292Ala missense_variant 0.16 ethambutol
embC 4240765 c.903C>G synonymous_variant 0.24 ethambutol
embC 4240780 c.918T>C synonymous_variant 0.23 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.21 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.19 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269144 c.690C>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
ubiA 4269164 p.Leu224Met missense_variant 0.24 ethambutol
aftB 4269171 c.-335C>G upstream_gene_variant 0.25 ethambutol
aftB 4269183 c.-347T>C upstream_gene_variant 0.23 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R