TB-Profiler result

Run: ERR5917710
Summary

Run ID: ERR5917710

Sample name:

Date: 2024-03-26T20:55:26.653010

Number of reads: 2564303

Percentage reads mapped: 82.17

Median coverage: 81.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.98
lineage4.1.2 Euro-American None 0.99
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.97
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB c.1327_1329delTTGinsCC Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761133 c.1327_1329delTTGinsCC frameshift_variant&missense_variant 0.3 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.33 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.35 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.22 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 636 c.636C>G synonymous_variant 0.16 isoniazid
dnaA 645 c.645A>G synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 654 c.654A>G synonymous_variant 0.15 isoniazid
dnaA 771 c.771A>C synonymous_variant 0.17 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.17 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.15 isoniazid
dnaA 805 c.805T>C synonymous_variant 0.19 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.19 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.2 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.2 isoniazid
dnaA 837 c.837A>G synonymous_variant 0.21 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.21 isoniazid
dnaA 843 c.843T>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.22 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.22 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.17 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.17 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.18 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.18 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.17 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.17 isoniazid
dnaA 1164 c.1164A>T synonymous_variant 0.18 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.16 isoniazid
dnaA 1177 p.Ala393Ser missense_variant 0.16 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.15 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.17 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.18 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.21 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.21 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.2 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.15 isoniazid
gyrB 6209 c.970C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6299 c.1060C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.17 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6878 c.1639T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6937 c.1698G>A synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7442 c.141G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7472 c.171T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7480 p.Phe60Tyr missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 7490 c.189C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7799 c.498A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7923 p.His208Tyr missense_variant 0.13 levofloxacin
moxifloxacin
gyrA 8039 c.738T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8054 c.753T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8057 c.756A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8093 c.792C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8348 c.1047C>A synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8363 c.1062C>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8498 c.1197C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8537 c.1236G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8556 p.Ala419His missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8562 c.1261C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8693 c.1392T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8717 c.1416C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8720 c.1419G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8729 c.1428T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8732 c.1431G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8747 c.1446A>G synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8765 p.Asp488Glu missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8767 p.Arg489Lys missense_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8779 p.Asp493Ala missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8796 c.1495_1497delATCinsGG frameshift_variant&missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8948 p.Leu549Phe missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8951 c.1650G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13481 c.78G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
fgd1 491031 c.249C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491038 p.Ile86Val missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491043 c.261T>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491049 c.267T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491063 p.Gly94Ala missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491137 p.Glu119Gln missense_variant 0.3 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Glu missense_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491181 c.399T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.34 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.39 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491331 c.549G>A synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491512 p.Asn244Asp missense_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491532 c.750G>T synonymous_variant 0.16 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491591 p.Lys270Met missense_variant 0.89 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575679 p.Asn111Ser missense_variant 0.88 ethionamide Not assoc w R
isoniazid Not assoc w R
mshA 575734 c.387T>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575767 c.420G>A synonymous_variant 0.2 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.19 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.21 ethionamide
isoniazid
ccsA 619570 c.-321G>C upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 619627 c.-264C>G upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620322 c.432G>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620367 c.477T>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620661 c.771C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAC frameshift_variant&missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620730 c.840C>T synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.15 capreomycin
amikacin
kanamycin
Rv0565c 657219 p.Ala84Val missense_variant 0.2 ethionamide
Rv0565c 657222 c.249C>G synonymous_variant 0.22 ethionamide
Rv0565c 657231 c.238_240delATCinsGG frameshift_variant&missense_variant 0.22 ethionamide Uncertain significance
Rv0565c 657237 c.234A>G synonymous_variant 0.22 ethionamide
Rv0565c 657242 p.Glu77Lys missense_variant 0.22 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.25 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.26 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.26 ethionamide
Rv0565c 657267 c.202_204delTCGinsCC frameshift_variant&synonymous_variant 0.25 ethionamide Uncertain significance
Rv0565c 657291 c.180C>G synonymous_variant 0.26 ethionamide
Rv0565c 657300 c.171C>T synonymous_variant 0.25 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.25 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.25 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.22 ethionamide
Rv0565c 657342 c.129T>C synonymous_variant 0.19 ethionamide
Rv0565c 657347 c.124A>C synonymous_variant 0.17 ethionamide
Rv0565c 657719 c.-249C>G upstream_gene_variant 0.16 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.16 ethionamide
hadA 732398 p.Ala157Thr missense_variant 0.14 isoniazid
nusG 734442 c.189G>A synonymous_variant 0.16 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.21 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.2 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.22 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.24 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.19 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.89 rifampicin Not assoc w R
rpoB 760181 c.375T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760340 c.534G>C synonymous_variant 0.17 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.18 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.26 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.28 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.26 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.27 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.23 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.18 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.17 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.18 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.21 rifampicin
rpoB 760763 c.957C>T synonymous_variant 0.16 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.21 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.21 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.22 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.25 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.21 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.24 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.24 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.3 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.32 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.36 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.29 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.31 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>A synonymous_variant 0.24 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.23 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.23 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.37 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.44 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.41 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.41 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761297 c.1491C>T synonymous_variant 0.27 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761360 c.1554T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.21 rifampicin
rpoB 761373 p.Val523His missense_variant 0.19 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.15 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.16 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.14 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.16 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.16 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.16 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.18 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.18 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.18 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.18 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.24 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>T upstream_gene_variant 0.26 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.21 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.2 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.2 rifampicin
rpoC 762521 c.-849C>G upstream_gene_variant 0.21 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.17 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.16 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.17 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.32 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.29 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.18 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.17 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.17 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.23 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.21 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.18 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTG frameshift_variant&missense_variant 0.2 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.23 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.26 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.26 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.3 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.28 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.27 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.27 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.28 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.29 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.28 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.29 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.28 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.28 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.26 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.25 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.24 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.23 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.21 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.21 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.21 rifampicin
rpoC 763919 c.550C>T synonymous_variant 0.2 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.19 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.19 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.17 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.17 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.2 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.22 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.25 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.25 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.25 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.27 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.31 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.31 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.26 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.28 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.31 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.29 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.27 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.2 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.22 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764381 p.Ser338Thr missense_variant 0.15 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.16 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.16 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.18 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTG frameshift_variant&missense_variant 0.19 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.19 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.2 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764714 c.1345C>T synonymous_variant 0.22 rifampicin
rpoC 764720 c.1351C>T synonymous_variant 0.24 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.22 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.24 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765404 p.Leu679Val missense_variant 0.18 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.16 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.16 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.22 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.22 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.25 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.19 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.17 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.17 rifampicin
rpoC 765577 c.2208G>C synonymous_variant 0.17 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.17 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.18 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.2 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.24 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.24 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.28 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.28 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.27 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765892 c.2523T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.16 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.19 rifampicin
rpoC 766015 c.2646G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.22 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.2 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.2 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.19 rifampicin
rpoC 766083 p.Ala905Glu missense_variant 0.15 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.15 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.14 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.16 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.24 rifampicin
rpoC 766444 c.3075C>G synonymous_variant 0.26 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.27 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.23 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.23 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.24 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766528 c.3159T>G synonymous_variant 0.27 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.24 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.21 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.29 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.31 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.32 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.3 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.2 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.19 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.28 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.29 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.3 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.26 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.27 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.2 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.23 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.25 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.2 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.21 rifampicin
rpoC 767275 c.3906T>C synonymous_variant 0.18 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.18 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775912 c.2569C>A synonymous_variant 0.14 clofazimine
bedaquiline
rpsL 781276 c.-284A>C upstream_gene_variant 1.0 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.19 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.2 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.21 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.19 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.2 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.19 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.22 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.22 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.21 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.24 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.25 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.23 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.23 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.25 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.25 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.26 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.28 streptomycin Uncertain significance
rplC 800612 c.-197A>G upstream_gene_variant 0.15 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.17 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.22 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.2 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.22 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.21 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.18 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.18 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.18 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.16 linezolid
rplC 800814 c.6A>G synonymous_variant 0.17 linezolid
rplC 800817 c.9A>T synonymous_variant 0.16 linezolid
rplC 800844 c.36T>C synonymous_variant 0.17 linezolid
rplC 800865 c.57A>G synonymous_variant 0.2 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.19 linezolid
rplC 800874 c.66A>G synonymous_variant 0.19 linezolid
rplC 800877 c.69A>C synonymous_variant 0.19 linezolid
rplC 800880 c.72A>G synonymous_variant 0.19 linezolid
rplC 800889 c.81C>G synonymous_variant 0.22 linezolid
rplC 800907 c.99C>G synonymous_variant 0.16 linezolid
rplC 801255 c.447C>T synonymous_variant 0.15 linezolid
rplC 801301 c.493C>A synonymous_variant 0.19 linezolid
rplC 801312 c.504G>C synonymous_variant 0.21 linezolid
rplC 801324 c.516T>C synonymous_variant 0.24 linezolid
rplC 801336 c.528C>G synonymous_variant 0.23 linezolid
rplC 801339 c.531T>C synonymous_variant 0.22 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.22 linezolid
rplC 801348 c.540T>G synonymous_variant 0.24 linezolid
rplC 801357 c.549T>C synonymous_variant 0.23 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.22 linezolid
rplC 801396 c.588T>C synonymous_variant 0.21 linezolid
rplC 801402 c.594T>C synonymous_variant 0.19 linezolid
rplC 801405 c.597T>C synonymous_variant 0.19 linezolid
fbiC 1303575 c.645G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303659 c.729T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303660 p.Val244Thr missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303701 c.771C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303716 c.786C>T synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.36 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.35 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1303881 c.951G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1303981 p.Val351Ile missense_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.35 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304058 c.1128G>A synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304080 p.Ala384Ser missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304091 p.Asp387Glu missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304092 p.Met388Leu missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304115 c.1185A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Ile missense_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304628 c.1698G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304671 p.Val581Thr missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304675 p.Gly582Glu missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.24 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.17 clofazimine
pretomanid
delamanid
sigE 1364748 c.336G>C synonymous_variant 0.16 pyrazinamide
sigE 1364763 c.351T>C synonymous_variant 0.17 pyrazinamide
sigE 1364767 c.355A>C synonymous_variant 0.17 pyrazinamide
sigE 1364784 c.372C>G synonymous_variant 0.2 pyrazinamide
sigE 1364802 c.390C>A synonymous_variant 0.22 pyrazinamide
sigE 1364811 c.399A>G synonymous_variant 0.23 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.24 pyrazinamide
sigE 1364835 c.423C>G synonymous_variant 0.24 pyrazinamide
sigE 1364839 c.427T>C synonymous_variant 0.25 pyrazinamide
sigE 1364862 c.450C>G synonymous_variant 0.21 pyrazinamide
sigE 1364865 c.453G>C synonymous_variant 0.21 pyrazinamide
sigE 1364866 c.454_456delGCTinsTG frameshift_variant&missense_variant 0.22 pyrazinamide Uncertain significance
sigE 1364887 c.475_477delTTAinsCG frameshift_variant&missense_variant 0.2 pyrazinamide Uncertain significance
sigE 1364904 p.Asp164Glu missense_variant 0.18 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.17 pyrazinamide
sigE 1364928 c.516C>T synonymous_variant 0.16 pyrazinamide
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.26 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.27 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1673589 c.-613A>G upstream_gene_variant 0.16 ethionamide
isoniazid
inhA 1673610 c.-592C>T upstream_gene_variant 0.15 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.16 ethionamide
isoniazid
inhA 1674342 c.141T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674352 p.Thr51Val missense_variant 0.21 ethionamide
isoniazid
inhA 1674368 p.Ala56Glu missense_variant 0.19 ethionamide
isoniazid
inhA 1674379 c.178C>T synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674382 p.Leu61Ile missense_variant 0.16 ethionamide
isoniazid
inhA 1674387 c.186A>G synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674399 c.198A>G synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674693 c.492C>G synonymous_variant 0.18 ethionamide
isoniazid
rpsA 1833589 c.48A>T synonymous_variant 0.15 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.15 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.25 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.22 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.23 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.3 pyrazinamide
rpsA 1834097 p.Ser186Thr missense_variant 0.16 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.17 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.23 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.28 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.16 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.18 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.17 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.16 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.16 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.18 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.18 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.18 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.19 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.16 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2155680 c.432G>C synonymous_variant 0.18 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.18 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.19 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.21 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.2 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.18 isoniazid
katG 2155741 p.Gly124Asp missense_variant 0.15 isoniazid Uncertain significance
katG 2155747 p.Ala122Gly missense_variant 0.17 isoniazid
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517947 c.-168C>T upstream_gene_variant 0.24 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.22 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.2 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.19 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.23 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.22 isoniazid
kasA 2518570 c.456G>C synonymous_variant 0.22 isoniazid
kasA 2518574 c.460_462delATCinsGG frameshift_variant&missense_variant 0.23 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.23 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.24 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.26 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.25 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.25 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.22 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.2 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.2 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.18 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.16 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.17 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.22 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.21 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.21 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.21 isoniazid
kasA 2518816 c.702C>A synonymous_variant 0.23 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.23 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.23 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.24 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.21 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.22 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.22 isoniazid
kasA 2518888 c.774C>T synonymous_variant 0.21 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.17 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.14 isoniazid
kasA 2519176 c.1062G>A synonymous_variant 0.16 isoniazid
Rv2477c 2782537 c.1506T>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782576 c.1467C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782582 c.1461C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782587 p.Leu486Val missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782591 c.1452T>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.28 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783243 p.Thr267Ser missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783320 c.723C>T synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783332 c.711T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783365 c.678C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783373 p.Glu224Gln missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783920 c.123G>C synonymous_variant 0.57 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.28 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2680 2996034 c.-71G>A upstream_gene_variant 0.17 capreomycin Uncertain significance
Rv2680 2996136 p.Ser11Asn missense_variant 0.19 capreomycin
Rv2752c 3066002 p.Met64Leu missense_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066024 c.168T>C synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066050 p.Leu48Met missense_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066342 c.-151G>A upstream_gene_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066350 c.-159T>A upstream_gene_variant 0.14 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066360 c.-169T>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067355 c.591A>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.16 para-aminosalicylic_acid
thyX 3067526 c.420C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067640 c.306G>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067643 c.303C>T synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067724 c.222G>A synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.17 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074010 c.462C>A synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074117 c.355C>T synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074120 c.352T>C synonymous_variant 0.18 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624317 c.594C>G synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624323 c.588G>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624335 c.576C>T synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624339 p.Arg191His missense_variant 0.22 bedaquiline
rifampicin
lpqB 3624346 p.Ser189Pro missense_variant 0.21 bedaquiline
rifampicin
lpqB 3624371 c.540T>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624389 c.522C>G synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624401 c.510C>T synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624407 c.504C>G synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624422 c.489G>C synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624425 p.Glu162Ala missense_variant 0.2 bedaquiline
rifampicin
lpqB 3624428 c.483A>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624452 c.459T>C synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624464 c.447A>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624470 c.441T>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624476 c.435C>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624482 c.429T>C synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624485 p.Asp142Gly missense_variant 0.17 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3624491 c.420G>C synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.15 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625543 c.-633G>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.2 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.23 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.32 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.31 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.26 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.26 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626795 c.-182C>T upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3626840 c.-227C>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627170 c.-557C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627188 c.160_162delTTAinsCG frameshift_variant&missense_variant 0.19 bedaquiline
rifampicin
mtrB 3627191 c.-578G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3627197 c.-584T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3627227 c.123T>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.17 bedaquiline
rifampicin
rpoA 3877503 c.1005G>C synonymous_variant 0.19 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.19 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.2 rifampicin
rpoA 3877542 c.966C>T synonymous_variant 0.21 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.18 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.25 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.19 rifampicin
rpoA 3877677 c.829_831delGCGinsAC frameshift_variant&missense_variant 0.17 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.22 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.23 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.23 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.2 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.21 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.27 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.24 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.24 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.24 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.24 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.26 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.27 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.29 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.25 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.24 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.25 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.27 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.29 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.29 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.29 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.29 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.3 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.27 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.27 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.3 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.27 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.29 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.3 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.26 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.28 rifampicin
rpoA 3878364 c.144A>G synonymous_variant 0.25 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.23 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.26 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.28 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.28 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.27 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.26 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.19 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.2 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.19 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.15 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.16 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878781 c.-274A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878782 c.-275G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.21 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.24 rifampicin
rpoA 3878826 c.-319A>T upstream_gene_variant 0.24 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.21 rifampicin
rpoA 3878838 c.-331A>C upstream_gene_variant 0.2 rifampicin
rpoA 3878839 c.-332C>G upstream_gene_variant 0.2 rifampicin
rpoA 3878842 c.-335G>C upstream_gene_variant 0.2 rifampicin
rpoA 3878845 c.-338G>T upstream_gene_variant 0.2 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.22 rifampicin
rpoA 3878875 c.-368C>T upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878924 c.-417G>C upstream_gene_variant 0.19 rifampicin
rpoA 3878938 c.-431T>G upstream_gene_variant 0.21 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878956 c.-449G>C upstream_gene_variant 0.22 rifampicin
rpoA 3878962 c.-455G>C upstream_gene_variant 0.22 rifampicin
rpoA 3878968 c.-461T>G upstream_gene_variant 0.24 rifampicin
rpoA 3878976 c.-469A>G upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878989 c.-482G>C upstream_gene_variant 0.3 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.25 rifampicin
rpoA 3879012 c.-505C>T upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3879013 c.-506A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.26 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.3 rifampicin
rpoA 3879040 c.-533G>C upstream_gene_variant 0.3 rifampicin
rpoA 3879049 c.-542A>G upstream_gene_variant 0.31 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.26 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.22 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879136 c.-629A>G upstream_gene_variant 0.19 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.18 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.16 rifampicin
clpC1 4038271 p.Pro812Ala missense_variant 0.2 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.2 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.24 pyrazinamide
clpC1 4038308 c.2395_2397delGTGinsAC frameshift_variant&missense_variant 0.24 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.27 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.15 pyrazinamide
clpC1 4038462 p.Ala748Glu missense_variant 0.15 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.16 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038713 c.1992T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.22 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.25 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039127 c.1578G>A synonymous_variant 0.2 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039268 c.1437C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.18 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.22 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039787 c.916_918delTCGinsAGC synonymous_variant 0.2 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.19 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.18 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.23 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.22 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.18 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040092 p.Ser205Thr missense_variant 0.14 pyrazinamide
clpC1 4040234 c.471C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.22 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.35 pyrazinamide
clpC1 4040264 c.441C>T synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040267 c.438A>G synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.38 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.38 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.39 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.4 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.39 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.16 pyrazinamide
panD 4044749 c.-468G>A upstream_gene_variant 0.15 pyrazinamide
glpK 4138538 c.1218C>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138541 c.1215C>T synonymous_variant 0.14 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138547 c.1209C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.17 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138695 p.Pro354Asp missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138703 c.1053C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138715 c.1041G>A synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138747 c.1009C>T synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138751 c.1005T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138772 c.982_984delTCGinsGC frameshift_variant&missense_variant 0.16 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138781 c.975G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4240654 c.792C>T synonymous_variant 0.14 ethambutol
embC 4240706 p.Val282Thr missense_variant 0.16 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.24 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.23 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.23 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.3 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.28 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.27 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.25 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.22 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.21 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.2 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.24 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.24 ethambutol
embC 4240919 c.1057_1059delCTCinsTG frameshift_variant&missense_variant 0.22 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.21 ethambutol
embC 4240945 c.1083T>C synonymous_variant 0.19 ethambutol
embC 4240951 c.1089C>G synonymous_variant 0.21 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.19 ethambutol
embC 4240957 c.1095C>G synonymous_variant 0.19 ethambutol
embC 4240966 c.1104G>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4240979 p.Thr373Gln missense_variant 0.18 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.18 ethambutol
embC 4240990 c.1128A>G synonymous_variant 0.18 ethambutol
embC 4240996 c.1134G>C synonymous_variant 0.18 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.19 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.19 ethambutol
embC 4241026 c.1164C>G synonymous_variant 0.18 ethambutol
embC 4241035 c.1173G>A synonymous_variant 0.17 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.19 ethambutol
embC 4241137 c.1275G>C synonymous_variant 0.18 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.18 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 0.16 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 0.99 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.97 ethambutol Not assoc w R
embA 4245137 c.1905T>C synonymous_variant 0.18 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.18 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.15 ethambutol
embB 4245737 c.-777A>C upstream_gene_variant 0.22 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.23 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.22 ethambutol
embA 4245771 p.Asn847Ser missense_variant 0.21 ethambutol Uncertain significance
embA 4245807 c.2575_2577delTTAinsCG frameshift_variant&missense_variant 0.18 ethambutol Uncertain significance
embA 4245820 p.Ser863Thr missense_variant 0.16 ethambutol
embB 4245830 c.-684G>C upstream_gene_variant 0.17 ethambutol
embB 4247365 c.852A>C synonymous_variant 0.15 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.18 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.2 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.21 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.22 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.23 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.21 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.21 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.2 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.18 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.15 ethambutol
embB 4247743 c.1230C>G synonymous_variant 0.16 ethambutol
embB 4247746 c.1233C>A synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247776 c.1263G>T synonymous_variant 0.19 ethambutol
embB 4247779 c.1266C>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247785 c.1272G>C synonymous_variant 0.19 ethambutol
embB 4247800 c.1287A>C synonymous_variant 0.2 ethambutol
embB 4247806 c.1293G>C synonymous_variant 0.2 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.19 ethambutol
embB 4247824 c.1311C>G synonymous_variant 0.17 ethambutol
embB 4247830 c.1317A>C synonymous_variant 0.17 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.16 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4247890 c.1377C>T synonymous_variant 0.15 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4247986 c.1473C>G synonymous_variant 0.16 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.17 ethambutol
embB 4248011 p.Ser500Ala missense_variant 0.18 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.18 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.17 ethambutol Uncertain significance
embB 4248052 c.1539G>A synonymous_variant 0.16 ethambutol
embB 4248055 c.1542G>C synonymous_variant 0.17 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.21 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.26 ethambutol
embB 4248095 c.1582_1584delCTCinsTG frameshift_variant&missense_variant 0.24 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.26 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.28 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.28 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.27 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.27 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.3 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.33 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.34 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.35 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.35 ethambutol
embB 4248298 c.1785C>T synonymous_variant 0.29 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.32 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.3 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.3 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.24 ethambutol
embB 4248346 c.1833G>C synonymous_variant 0.23 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.21 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.21 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.23 ethambutol
embB 4248361 c.1848A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248362 p.Ser617Ala missense_variant 0.22 ethambutol
embB 4248398 c.1885C>T synonymous_variant 0.17 ethambutol
embB 4248409 c.1896A>G synonymous_variant 0.16 ethambutol
embB 4248416 p.Leu635Met missense_variant 0.16 ethambutol
embB 4248419 p.Leu636Met missense_variant 0.17 ethambutol
embB 4248432 p.Trp640Leu missense_variant 0.16 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin