TB-Profiler result

Run: ERR4816904
Summary

Run ID: ERR4816904

Sample name:

Date: 2024-04-15T16:25:50.996511

Number of reads: 1283023

Percentage reads mapped: 57.68

Median coverage: 30.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 1.0
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 1.0
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 6649 c.-653T>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.35 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.41 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>T upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.46 levofloxacin
moxifloxacin
gyrB 6715 c.1476C>T synonymous_variant 0.49 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrA 6727 c.-575G>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.37 levofloxacin Uncertain significance
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrA 6764 c.-538C>T upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6772 c.1533C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6775 c.-527G>T upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 6798 p.Gly520Ala missense_variant 0.45 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6808 c.1569C>G synonymous_variant 0.41 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6811 c.1572C>T synonymous_variant 0.34 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6856 c.1617T>C synonymous_variant 0.42 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6862 c.-440C>A upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrA 6866 c.-436C>T upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrA 6869 c.-433T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6872 c.-430T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6949 c.-353A>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6967 c.-335T>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrB 6968 c.1729_1731delGACinsCG frameshift_variant&missense_variant 0.42 levofloxacin Uncertain significance
moxifloxacin
gyrA 6976 c.-326A>G upstream_gene_variant 0.55 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>G upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 7006 c.-296T>G upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrB 7010 p.Leu591Met missense_variant 0.53 levofloxacin
moxifloxacin
gyrA 7018 c.-284G>C upstream_gene_variant 0.54 levofloxacin
moxifloxacin
gyrA 7024 c.-278G>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.5 levofloxacin
moxifloxacin
gyrB 7051 p.Glu604Asp missense_variant 0.42 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.44 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>T upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>T upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.31 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 7100 c.1861T>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7120 c.-182T>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 0.36 levofloxacin
moxifloxacin
gyrB 7126 c.1887G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7129 c.-173T>G upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>A upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 7153 c.-149G>T upstream_gene_variant 0.38 levofloxacin
moxifloxacin
gyrB 7159 c.1920C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7162 c.-140C>G upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrA 7168 c.-134C>G upstream_gene_variant 0.39 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.37 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7189 c.-113C>T upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrB 7210 p.Asp657Glu missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7480 p.Phe60Tyr missense_variant 0.33 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7496 c.195C>G synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7499 c.198G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>A synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7574 c.273G>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7831 c.531_532delGT frameshift_variant 0.25 levofloxacin
moxifloxacin
gyrA 7837 c.536_540delGCGGCinsCGGCGGT frameshift_variant&missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7847 c.546G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7853 c.552C>T synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>C synonymous_variant 0.39 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7868 p.Ile189Met missense_variant 0.29 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8294 c.993T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8354 c.1053G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8924 c.1623C>T synonymous_variant 0.38 levofloxacin
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491591 p.Lys270Met missense_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575679 p.Asn111Ser missense_variant 1.0 ethionamide Not assoc w R
isoniazid Not assoc w R
nusG 734445 c.192C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734452 c.199_201delGAAinsCG frameshift_variant&missense_variant 0.29 rifampicin
nusG 734460 c.207G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
nusG 734497 c.244_246delGTGinsAC frameshift_variant&missense_variant 0.31 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
nusG 734544 c.291C>T synonymous_variant 0.28 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.17 rifampicin
rpoB 759422 c.-385G>A upstream_gene_variant 1.0 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.97 rifampicin Not assoc w R
rpoB 760184 c.378A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.4 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.29 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.28 rifampicin Uncertain significance
rpoB 760382 c.576G>C synonymous_variant 0.29 rifampicin
rpoB 760400 c.594G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.34 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.36 rifampicin Uncertain significance
rpoB 760412 c.606C>T synonymous_variant 0.39 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>A synonymous_variant 0.39 rifampicin
rpoB 760430 c.624T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760433 c.627C>T synonymous_variant 0.46 rifampicin
rpoB 760454 c.648C>G synonymous_variant 0.39 rifampicin
rpoB 760457 c.651C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760469 c.663C>T synonymous_variant 0.33 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760588 p.Thr261Ile missense_variant 0.26 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.27 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.27 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.26 rifampicin
rpoB 760607 c.801G>C synonymous_variant 0.31 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760668 p.Thr288Ala missense_variant 0.26 rifampicin Uncertain significance
rpoB 760674 c.868T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760703 c.897C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.26 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.26 rifampicin
rpoB 761147 c.1341C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761178 c.1372_1374delTCAinsAC frameshift_variant&missense_variant 0.35 rifampicin
rpoB 761186 p.Glu460Asp missense_variant 0.34 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.18 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761639 c.1833G>C synonymous_variant 0.38 rifampicin
rpoB 761645 c.1839C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.35 rifampicin
rpoB 761666 c.1860G>C synonymous_variant 0.3 rifampicin
rpoB 761669 c.1863C>T synonymous_variant 0.31 rifampicin
rpoB 761675 c.1869G>T synonymous_variant 0.4 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.15 rifampicin
rpoB 761924 c.2118G>A synonymous_variant 0.18 rifampicin
rpoB 761930 c.2124G>C synonymous_variant 0.18 rifampicin
rpoB 761933 c.2127G>C synonymous_variant 0.18 rifampicin
rpoB 761936 c.2130C>T synonymous_variant 0.17 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>T synonymous_variant 0.29 rifampicin
rpoB 761955 p.Ile717Val missense_variant 0.31 rifampicin Uncertain significance
rpoB 761969 c.2163G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761990 c.2184G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762038 c.2232C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>T synonymous_variant 0.37 rifampicin
rpoB 762101 c.2295C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.19 rifampicin Uncertain significance
rpoB 762149 c.2343G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762179 c.2373C>T synonymous_variant 0.19 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>T synonymous_variant 0.43 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762299 c.2493G>C synonymous_variant 0.42 rifampicin
rpoB 762314 c.2508C>T synonymous_variant 0.26 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.25 rifampicin Uncertain significance
rpoB 762894 c.3088C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 762911 c.-459C>T upstream_gene_variant 0.32 rifampicin
rpoB 762917 c.3111C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.41 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763034 c.-336C>A upstream_gene_variant 0.52 rifampicin
rpoB 763040 c.3234C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.47 rifampicin
rpoC 763633 c.264T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.35 rifampicin
rpoC 764320 c.951C>A synonymous_variant 0.38 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.39 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>T synonymous_variant 0.42 rifampicin
rpoC 764377 c.1008C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCC frameshift_variant&missense_variant 0.35 rifampicin
rpoC 764611 c.1242G>C synonymous_variant 0.37 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>T synonymous_variant 0.46 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 764719 c.1350G>A synonymous_variant 0.52 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764810 c.1441_1443delCCCinsGT frameshift_variant&missense_variant 0.3 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.38 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.35 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.34 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.28 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764962 c.1593G>A synonymous_variant 0.29 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765007 c.1638T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765008 c.1639T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765011 c.1642_1644delAGCinsTCG synonymous_variant 0.23 rifampicin
rpoC 765016 c.1647C>G synonymous_variant 0.22 rifampicin
rpoC 765019 c.1650A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.24 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765085 c.1716T>C synonymous_variant 0.26 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>T synonymous_variant 0.24 rifampicin
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765394 c.2025G>A synonymous_variant 0.19 rifampicin
rpoC 765403 c.2034G>C synonymous_variant 0.21 rifampicin
rpoC 765405 p.Leu679His missense_variant 0.21 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765412 c.2043T>C synonymous_variant 0.24 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765449 c.2080_2082delGCCinsTG frameshift_variant&missense_variant 0.26 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>G synonymous_variant 0.22 rifampicin
rpoC 765480 p.Tyr704Phe missense_variant 0.24 rifampicin Uncertain significance
rpoC 765496 c.2127C>T synonymous_variant 0.24 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765871 c.2502T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765875 p.Val836Ile missense_variant 0.31 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.35 rifampicin
rpoC 765907 c.2538G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765946 c.2577C>T synonymous_variant 0.27 rifampicin
rpoC 765947 c.2578T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765962 c.2593_2595delTTGinsCT frameshift_variant&synonymous_variant 0.21 rifampicin
rpoC 765973 c.2604C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767221 c.3852C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781817 c.258G>T synonymous_variant 0.29 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.4 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.38 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.4 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.4 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.39 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.38 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.3 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.3 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.29 streptomycin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.52 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.5 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.93 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 1.0 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472846 n.1001C>T non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>A non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>C non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.83 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>A non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.74 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.56 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.69 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid
rrl 1473814 n.157A>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1473815 n.158T>G non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1473839 n.182G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524_525insT non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474184 n.527C>A non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474185 n.529delA non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474292 n.636_649delTCCTCTCCGGAGGA non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>A non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756A>C non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474415 n.759_781delCACACGCGCATACGCGCGTGTGA non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474496 n.839C>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1052_1057delGTGGTGinsAATAAGT non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1474717 n.1060A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474743 n.1086T>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1406delA non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475076 n.1419C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475202 n.1545G>C non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475443 n.1786G>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2105_2106delGC non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.71 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>T non_coding_transcript_exon_variant 0.71 capreomycin
linezolid
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>A non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.69 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.59 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.62 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674054 c.-148T>C upstream_gene_variant 0.33 ethionamide
isoniazid
inhA 1674060 c.-142A>G upstream_gene_variant 0.36 ethionamide
isoniazid
inhA 1674069 c.-133G>A upstream_gene_variant 0.36 ethionamide
isoniazid
inhA 1674072 c.-130C>G upstream_gene_variant 0.38 ethionamide
isoniazid
inhA 1674078 c.-124C>T upstream_gene_variant 0.36 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.36 ethionamide
isoniazid
inhA 1674084 c.-118C>T upstream_gene_variant 0.4 ethionamide
isoniazid
inhA 1674600 c.399G>T synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674601 p.Leu134Val missense_variant 0.38 ethionamide
isoniazid
inhA 1674609 c.408G>C synonymous_variant 0.4 ethionamide
isoniazid
inhA 1674621 c.420C>G synonymous_variant 0.38 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.37 ethionamide
isoniazid
inhA 1674627 c.426T>C synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674628 c.427_428delTCinsAG synonymous_variant 0.33 ethionamide
isoniazid
inhA 1674636 c.435C>A synonymous_variant 0.34 ethionamide
isoniazid
inhA 1674656 p.Ser152Thr missense_variant 0.34 ethionamide
isoniazid
rpsA 1833254 c.-288G>T upstream_gene_variant 1.0 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.13 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.14 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.14 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.15 pyrazinamide
rpsA 1833616 c.75A>T synonymous_variant 0.16 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.2 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.17 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.21 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.2 pyrazinamide
rpsA 1833697 c.156C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833700 c.159C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.21 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833751 c.210C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1833760 c.219C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.23 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.22 pyrazinamide
rpsA 1833838 c.297G>T synonymous_variant 0.22 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.33 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.31 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.28 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.28 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.23 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.37 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.36 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.33 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.41 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.42 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834073 p.Lys178Arg missense_variant 0.46 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.33 pyrazinamide
rpsA 1834228 c.687C>A synonymous_variant 0.24 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.24 pyrazinamide
rpsA 1834234 c.693G>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834240 c.699T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834246 c.705G>T synonymous_variant 0.22 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.29 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.41 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.39 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834339 c.798C>T synonymous_variant 0.39 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.38 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>T synonymous_variant 0.3 pyrazinamide
rpsA 1834405 c.864C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834408 c.867C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.3 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834480 c.939C>G synonymous_variant 0.24 pyrazinamide
rpsA 1834483 c.942G>A synonymous_variant 0.24 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.33 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>C upstream_gene_variant 0.41 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.36 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
Rv2680 2996085 c.-20G>A upstream_gene_variant 0.27 capreomycin Uncertain significance
Rv2680 2996136 p.Ser11Asn missense_variant 0.17 capreomycin
thyA 3073950 c.522G>T synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073971 c.501C>T synonymous_variant 0.25 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626717 c.-104C>T upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3626741 c.609C>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626750 c.-137T>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626756 c.594C>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626762 c.588G>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626765 c.585C>T synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626776 c.-163A>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626798 c.-185T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626846 c.504G>A synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626852 c.-239G>A upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3626857 c.-244T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626858 c.-245A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627756 c.-407A>T upstream_gene_variant 1.0 bedaquiline
rifampicin
rpoA 3877569 c.937_939delCCGinsAC frameshift_variant&missense_variant 0.33 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877596 c.912G>C synonymous_variant 0.27 rifampicin
rpoA 3877602 c.906C>T synonymous_variant 0.3 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877662 c.846C>T synonymous_variant 0.29 rifampicin
rpoA 3877665 c.843C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.26 rifampicin
rpoA 3877677 c.831G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>T synonymous_variant 0.3 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877728 c.780C>G synonymous_variant 0.27 rifampicin
rpoA 3877734 c.774G>C synonymous_variant 0.27 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.31 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877752 p.Asp252Glu missense_variant 0.37 rifampicin
rpoA 3877758 c.750G>C synonymous_variant 0.37 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877773 c.735G>C synonymous_variant 0.33 rifampicin
rpoA 3877776 c.732T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877785 c.723C>A synonymous_variant 0.36 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>T synonymous_variant 0.38 rifampicin
rpoA 3877848 c.660C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877860 c.648C>T synonymous_variant 0.31 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877881 c.627G>C synonymous_variant 0.39 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.29 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877900 p.Ser203Thr missense_variant 0.36 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.28 rifampicin
rpoA 3877962 c.546G>C synonymous_variant 0.23 rifampicin
rpoA 3877974 c.534G>C synonymous_variant 0.23 rifampicin
rpoA 3877977 p.Lys177Asn missense_variant 0.22 rifampicin Uncertain significance
rpoA 3877983 c.525C>G synonymous_variant 0.17 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.18 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.26 rifampicin
rpoA 3878050 p.Arg153Lys missense_variant 0.27 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.34 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.43 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.44 rifampicin
rpoA 3878079 c.429C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>C synonymous_variant 0.43 rifampicin
rpoA 3878102 p.Val136Ile missense_variant 0.5 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.48 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.41 rifampicin
rpoA 3878127 c.381G>C synonymous_variant 0.44 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.44 rifampicin
rpoA 3878143 p.Gly122Asp missense_variant 0.45 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878175 c.333G>T synonymous_variant 0.36 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878274 c.234G>C synonymous_variant 0.37 rifampicin
rpoA 3878283 p.Glu75Asp missense_variant 0.37 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.38 rifampicin
rpoA 3878364 c.144A>C synonymous_variant 0.39 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.39 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.37 rifampicin
rpoA 3878373 c.135G>C synonymous_variant 0.39 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878400 c.108T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
clpC1 4038749 c.1956C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>A synonymous_variant 0.18 pyrazinamide
clpC1 4038767 c.1938G>T synonymous_variant 0.2 pyrazinamide
clpC1 4038770 c.1935C>A synonymous_variant 0.21 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.29 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.35 pyrazinamide
clpC1 4038842 c.1863G>T synonymous_variant 0.32 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.36 pyrazinamide
clpC1 4038860 c.1845G>T synonymous_variant 0.35 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4038881 c.1824C>A synonymous_variant 0.32 pyrazinamide
clpC1 4038884 c.1821C>T synonymous_variant 0.34 pyrazinamide
clpC1 4038890 c.1815G>A synonymous_variant 0.33 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4038980 c.1725C>T synonymous_variant 0.34 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039031 c.1674T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039166 c.1539G>A synonymous_variant 0.43 pyrazinamide
clpC1 4039169 c.1536A>G synonymous_variant 0.43 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.42 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.47 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.49 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.49 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.49 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.51 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039238 c.1467C>T synonymous_variant 0.4 pyrazinamide
clpC1 4039265 c.1440C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039277 c.1428C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039280 c.1425G>T synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039283 c.1422C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039286 c.1419T>G synonymous_variant 0.23 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039316 p.Glu463Asp missense_variant 0.23 pyrazinamide
clpC1 4039319 c.1386T>A synonymous_variant 0.2 pyrazinamide
clpC1 4039322 c.1383T>G synonymous_variant 0.21 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039589 c.1116G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.35 pyrazinamide
clpC1 4039649 c.1056G>T synonymous_variant 0.37 pyrazinamide
clpC1 4039652 c.1053G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039787 c.918G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039805 c.900C>T synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4039814 c.891C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.37 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.39 pyrazinamide
clpC1 4039844 c.861C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039850 c.855T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039931 c.774T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.31 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4040000 c.705C>T synonymous_variant 0.33 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040057 c.648C>T synonymous_variant 0.26 pyrazinamide
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.97 capreomycin
amikacin
kanamycin