TB-Profiler result

Run: SRR1183145
Summary

Run ID: SRR1183145

Sample name:

Date: 2025-02-11T20:11:15.358867

Number of reads: 3103937

Percentage reads mapped: 68.01

Median coverage: 69.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.97
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.98
lineage2.2 East-Asian (Beijing) RD105;RD207 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
p.Ala356Val Uncertain significance Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
embB 4247448 p.His312Arg missense_variant 0.3 ethambutol Mutation from literature
embB 4247580 p.Ala356Val missense_variant 0.18 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 795 c.795A>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 828 c.828T>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 837 c.837A>G synonymous_variant 0.2 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.19 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.22 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 1104 c.1104T>C synonymous_variant 0.2 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.18 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.16 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.16 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.19 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.18 isoniazid
gyrB 5308 c.69G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 5341 c.102T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 5449 c.210T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 5455 c.216T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6091 c.852G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6097 c.858G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6121 c.882C>T synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6145 c.906C>T synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrB 6178 c.939C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 6181 c.942C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrB 6196 c.957C>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrB 6247 c.1008G>A synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6259 p.Asp340Glu missense_variant 0.33 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6299 c.1060C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6313 c.-989C>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7024 c.-278G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7030 c.-272C>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7081 c.-221T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7787 c.486G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7838 c.537C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7850 c.549C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7859 c.558A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8531 c.1230G>A synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8561 c.1260A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8562 c.1261C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8571 c.1270C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>T synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8655 p.Ile452Val missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8723 c.1422G>A synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8729 c.1428T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8756 c.1455A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8762 c.1461G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8767 p.Arg489Lys missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8828 c.1527T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8855 c.1554C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8858 c.1557T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8876 c.1575C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>A synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8942 c.1641G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9050 p.Asp583Glu missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9065 c.1764C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9071 c.1770G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9185 c.1884C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9452 c.2151G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
fgd1 490803 c.21T>A synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 490818 c.36C>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 490830 c.48A>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 490851 c.69A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490854 c.72C>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 490857 c.75C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 490896 c.114C>T synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491043 c.261T>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491106 c.324T>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491526 c.744T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491542 c.760T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491547 c.765A>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491550 c.768T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491601 c.819T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491616 c.834A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575539 c.192C>T synonymous_variant 0.18 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575561 p.Met72Val missense_variant 0.22 isoniazid
ethionamide
mshA 575590 c.243T>G synonymous_variant 0.23 isoniazid
ethionamide
mshA 575635 c.288A>G synonymous_variant 0.19 isoniazid
ethionamide
mshA 575652 p.Arg102Gln missense_variant 0.19 isoniazid
ethionamide
mshA 575659 c.312A>G synonymous_variant 0.2 isoniazid
ethionamide
mshA 575662 c.315C>A synonymous_variant 0.17 isoniazid
ethionamide
mshA 575665 c.318G>C synonymous_variant 0.18 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575705 c.358T>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.19 isoniazid
ethionamide
mshA 575734 c.387T>G synonymous_variant 0.15 isoniazid
ethionamide
mshA 575746 c.399C>G synonymous_variant 0.26 isoniazid
ethionamide
mshA 575772 p.Val142Ala missense_variant 0.29 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.34 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.35 isoniazid
ethionamide
mshA 575824 c.477T>C synonymous_variant 0.23 isoniazid
ethionamide
mshA 575842 c.495G>C synonymous_variant 0.18 isoniazid
ethionamide
mshA 575848 c.501C>T synonymous_variant 0.18 isoniazid
ethionamide
mshA 575860 c.513G>A synonymous_variant 0.18 isoniazid
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.17 isoniazid
ethionamide
mshA 575872 c.525C>T synonymous_variant 0.17 isoniazid
ethionamide
mshA 575878 c.531A>G synonymous_variant 0.22 isoniazid
ethionamide
mshA 575884 c.537G>C synonymous_variant 0.31 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.28 isoniazid
ethionamide
mshA 575905 c.558G>C synonymous_variant 0.21 isoniazid
ethionamide
mshA 575907 p.Ala187Val missense_variant 0.76 isoniazid Not assoc w R
ethionamide Not assoc w R
mshA 575916 p.Asp190Ala missense_variant 0.17 isoniazid
ethionamide
mshA 575924 p.Gly193Ile missense_variant 0.15 isoniazid
ethionamide
ccsA 619672 c.-219A>G upstream_gene_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620604 c.714C>G synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620607 c.717T>G synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620613 c.723C>T synonymous_variant 0.24 kanamycin
capreomycin
amikacin
ccsA 620619 c.729G>A synonymous_variant 0.22 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620622 c.732G>C synonymous_variant 0.25 kanamycin
capreomycin
amikacin
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
ccsA 620631 c.741T>G synonymous_variant 0.21 kanamycin
capreomycin
amikacin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.18 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.16 ethionamide
hadA 731738 c.-192G>T upstream_gene_variant 0.15 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.31 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.17 isoniazid
hadA 731798 c.-132C>G upstream_gene_variant 0.16 isoniazid
hadA 732329 p.Leu134Ile missense_variant 0.17 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.16 isoniazid
hadA 732361 c.432C>T synonymous_variant 0.21 isoniazid
hadA 732376 c.447T>C synonymous_variant 0.2 isoniazid
hadA 732391 c.462T>A synonymous_variant 0.15 isoniazid
nusG 734407 p.Val52Ile missense_variant 0.26 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.26 rifampicin
nusG 734424 c.171G>T synonymous_variant 0.2 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.17 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>T synonymous_variant 0.2 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.29 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.22 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.2 rifampicin
nusG 734762 p.Ala170Val missense_variant 0.17 rifampicin
nusG 734769 c.516G>A synonymous_variant 0.16 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.25 rifampicin
nusG 734784 c.531G>A synonymous_variant 0.25 rifampicin
nusG 734790 c.537G>C synonymous_variant 0.19 rifampicin
nusG 734793 c.540C>T synonymous_variant 0.18 rifampicin
nusG 734826 c.573A>C synonymous_variant 0.3 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.26 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.2 rifampicin
mmaA3 737555 c.595C>A synonymous_variant 0.16 isoniazid
mmaA3 737562 c.588A>G synonymous_variant 0.18 isoniazid
mmaA3 737595 c.555G>A synonymous_variant 0.24 isoniazid
mmaA3 737598 p.Ile184Met missense_variant 0.23 isoniazid
mmaA3 737610 c.540A>C synonymous_variant 0.18 isoniazid
mmaA3 737613 c.537C>T synonymous_variant 0.18 isoniazid
mmaA3 737619 c.531C>G synonymous_variant 0.16 isoniazid
mmaA3 738347 c.-198C>G upstream_gene_variant 0.16 isoniazid
rpoB 760112 c.306T>C synonymous_variant 0.17 rifampicin
rpoB 760121 c.315T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.18 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.36 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.34 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760343 c.537G>C synonymous_variant 0.19 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.16 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 760508 c.702G>C synonymous_variant 0.2 rifampicin
rpoB 760511 c.705G>C synonymous_variant 0.2 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.18 rifampicin Uncertain significance
rpoB 760528 p.Gln241Arg missense_variant 0.18 rifampicin
rpoB 760532 c.726T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.21 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760556 c.750G>A synonymous_variant 0.19 rifampicin
rpoB 760563 p.Arg253Met missense_variant 0.31 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.35 rifampicin
rpoB 760598 c.792C>T synonymous_variant 0.19 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.25 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760817 c.1011A>G synonymous_variant 0.18 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.2 rifampicin
rpoB 760859 c.1053T>G synonymous_variant 0.18 rifampicin
rpoB 760868 c.1062C>G synonymous_variant 0.19 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.18 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760971 c.1165C>A synonymous_variant 0.18 rifampicin
rpoB 760994 c.1188G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>T synonymous_variant 0.18 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761066 c.1260G>C synonymous_variant 0.18 rifampicin
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.22 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.22 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.24 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.22 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761354 c.1548C>T synonymous_variant 0.25 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761367 p.Glu521Gln missense_variant 0.26 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.26 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.27 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.29 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.31 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.22 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.31 rifampicin
rpoB 761471 c.1665C>G synonymous_variant 0.17 rifampicin
rpoB 761483 c.1677G>C synonymous_variant 0.27 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.29 rifampicin
rpoB 761502 p.Pro566Ala missense_variant 0.18 rifampicin
rpoB 761510 c.1704T>G synonymous_variant 0.2 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.27 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761582 c.1776G>A synonymous_variant 0.2 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.32 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.35 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.15 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762050 c.2244G>A synonymous_variant 0.18 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.3 rifampicin Uncertain significance
rpoB 762119 c.2313C>T synonymous_variant 0.17 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.18 rifampicin
rpoB 762134 c.2328C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.17 rifampicin
rpoB 762224 c.2418C>G synonymous_variant 0.17 rifampicin
rpoB 762236 c.2430G>A synonymous_variant 0.17 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>G synonymous_variant 0.31 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.29 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.17 rifampicin
rpoB 762269 c.2463G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762347 c.2541T>C synonymous_variant 0.21 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.19 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.18 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.21 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.2 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.21 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.23 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762510 p.Ala902Pro missense_variant 0.19 rifampicin Uncertain significance
rpoC 762533 c.-837T>C upstream_gene_variant 0.17 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.17 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.18 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.17 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762920 c.-450C>G upstream_gene_variant 0.15 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>A upstream_gene_variant 0.16 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.22 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>T upstream_gene_variant 0.17 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.22 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.17 rifampicin
rpoC 763206 c.-164_-163delAGinsTC upstream_gene_variant 0.17 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.16 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763505 c.136C>T synonymous_variant 0.17 rifampicin
rpoC 763636 c.267T>G synonymous_variant 0.23 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.19 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.22 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.26 rifampicin
rpoC 763771 c.402C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763781 p.Ser138Ala missense_variant 0.26 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763836 p.Ala156Val missense_variant 0.23 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.2 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.2 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.19 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.19 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.19 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.17 rifampicin
rpoC 763924 c.555G>A synonymous_variant 0.17 rifampicin
rpoC 763936 c.567C>G synonymous_variant 0.16 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.19 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.2 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764024 c.655T>C synonymous_variant 0.3 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.19 rifampicin
rpoC 764044 c.675T>G synonymous_variant 0.2 rifampicin
rpoC 764056 c.687G>T synonymous_variant 0.17 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.21 rifampicin
rpoC 764080 c.711C>T synonymous_variant 0.19 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.34 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.19 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764161 c.792G>C synonymous_variant 0.19 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.17 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.17 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.16 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764284 c.915G>C synonymous_variant 0.18 rifampicin
rpoC 764317 c.948C>G synonymous_variant 0.25 rifampicin
rpoC 764320 c.951C>T synonymous_variant 0.23 rifampicin
rpoC 764339 c.970C>T synonymous_variant 0.16 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.18 rifampicin
rpoC 764347 c.978G>C synonymous_variant 0.18 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>T synonymous_variant 0.16 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.24 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.23 rifampicin
rpoC 764452 c.1083T>G synonymous_variant 0.18 rifampicin
rpoC 764455 c.1086G>T synonymous_variant 0.17 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.21 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.17 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.17 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.2 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.16 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764767 c.1398G>C synonymous_variant 0.16 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764800 c.1431G>A synonymous_variant 0.16 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.2 rifampicin
rpoC 764833 c.1464A>G synonymous_variant 0.26 rifampicin
rpoC 764872 c.1503A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCTC synonymous_variant 0.19 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.16 rifampicin
rpoC 764918 p.Val517Met missense_variant 0.15 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765409 c.2040T>C synonymous_variant 0.21 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.15 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>T synonymous_variant 0.21 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>A synonymous_variant 0.19 rifampicin
rpoC 765529 c.2160C>T synonymous_variant 0.17 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.17 rifampicin
rpoC 765547 c.2178C>A synonymous_variant 0.27 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.24 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.23 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.23 rifampicin
rpoC 765628 c.2259G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765784 c.2415C>G synonymous_variant 0.22 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.21 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.22 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.22 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.25 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.25 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.17 rifampicin
rpoC 765952 c.2583G>C synonymous_variant 0.24 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766105 c.2736C>T synonymous_variant 0.19 rifampicin
rpoC 766274 p.Ala969Thr missense_variant 0.15 rifampicin
rpoC 766280 p.Ser971Gly missense_variant 0.15 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.21 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.18 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.22 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766417 c.3048C>T synonymous_variant 0.18 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.29 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.19 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.32 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.21 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766540 c.3171C>T synonymous_variant 0.18 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.27 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.23 rifampicin
rpoC 766570 c.3201T>C synonymous_variant 0.24 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.29 rifampicin
rpoC 766579 c.3210C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766585 c.3216T>C synonymous_variant 0.28 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.26 rifampicin
rpoC 766607 p.Ile1080Leu missense_variant 0.3 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.28 rifampicin
rpoC 766660 c.3291G>A synonymous_variant 0.15 rifampicin
rpoC 766666 c.3297C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766672 c.3303T>C synonymous_variant 0.25 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.24 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.28 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.21 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.17 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.17 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.2 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.17 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.22 rifampicin
rpoC 766975 c.3606C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.26 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.29 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 0.96 streptomycin Not assoc w R
rpsL 781571 c.12C>T synonymous_variant 0.2 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.34 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.31 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.18 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.35 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.33 streptomycin
rpsL 781658 c.99A>G synonymous_variant 0.22 streptomycin
rpsL 781664 c.105C>T synonymous_variant 0.22 streptomycin
rpsL 781667 c.108C>G synonymous_variant 0.21 streptomycin
rpsL 781709 c.150G>C synonymous_variant 0.18 streptomycin Not assoc w R - Interim
rpsL 781715 c.156T>C synonymous_variant 0.25 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.25 streptomycin
rpsL 781721 c.162C>G synonymous_variant 0.22 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.31 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.22 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.33 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.38 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.38 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.18 streptomycin
rpsL 781847 c.288G>A synonymous_variant 0.17 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.32 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.32 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.15 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.29 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.3 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.25 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.23 streptomycin Uncertain significance
rplC 800567 c.-242A>G upstream_gene_variant 0.24 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.23 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.24 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.24 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.25 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.21 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.26 linezolid
rplC 800714 c.-95C>T upstream_gene_variant 0.22 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.22 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.22 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.16 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.18 linezolid
rplC 800844 c.36T>C synonymous_variant 0.18 linezolid
rplC 801174 c.366T>C synonymous_variant 0.16 linezolid
rplC 801210 c.402T>C synonymous_variant 0.18 linezolid
rplC 801222 c.414T>C synonymous_variant 0.16 linezolid
rplC 801246 c.438C>G synonymous_variant 0.2 linezolid
rplC 801252 c.444G>C synonymous_variant 0.19 linezolid
rplC 801312 c.504G>C synonymous_variant 0.19 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303545 c.615A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304799 c.1869G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.27 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304915 p.Asp662Gly missense_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304940 c.2010A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304946 c.2016G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
sigE 1364727 c.315C>T synonymous_variant 0.17 pyrazinamide
sigE 1364820 c.408A>G synonymous_variant 0.16 pyrazinamide
sigE 1364866 p.Ala152Thr missense_variant 0.21 pyrazinamide
sigE 1364889 c.477A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
sigE 1364898 c.486C>T synonymous_variant 0.19 pyrazinamide
sigE 1364919 c.507T>C synonymous_variant 0.2 pyrazinamide
sigE 1364964 c.552T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
Rv1258c 1406760 c.580_581insC frameshift_variant 0.98 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
atpE 1461161 c.117C>T synonymous_variant 0.19 bedaquiline
atpE 1461167 c.123G>T synonymous_variant 0.18 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.19 bedaquiline
atpE 1461185 c.141G>A synonymous_variant 0.24 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.24 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.28 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.22 bedaquiline
atpE 1461230 c.186G>T synonymous_variant 0.21 bedaquiline
atpE 1461233 c.189A>C synonymous_variant 0.23 bedaquiline
atpE 1461254 c.210T>C synonymous_variant 0.2 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.15 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472031 n.186G>T non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472033 n.188A>G non_coding_transcript_exon_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.25 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472686 n.841G>A non_coding_transcript_exon_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.17 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473797 n.140G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475273 n.1616T>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475289 n.1632G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475290 n.1633A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.41 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475999 n.2342G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476595 n.2938C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476602 n.2945G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.3 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
inhA 1673547 c.-655T>C upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673955 c.-247G>C upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1674018 c.-184G>C upstream_gene_variant 0.15 isoniazid
ethionamide
inhA 1674033 c.-169T>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1674840 c.639C>T synonymous_variant 0.18 isoniazid Not assoc w R - Interim
ethionamide
inhA 1674846 p.Ile215Met missense_variant 0.16 isoniazid
ethionamide
inhA 1674870 c.669T>C synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674903 c.702T>C synonymous_variant 0.2 isoniazid
ethionamide
inhA 1674904 p.Ala235Pro missense_variant 0.19 isoniazid
ethionamide
rpsA 1833256 c.-286C>G upstream_gene_variant 0.2 pyrazinamide
rpsA 1833262 c.-280T>A upstream_gene_variant 0.22 pyrazinamide
rpsA 1833271 c.-271G>A upstream_gene_variant 0.19 pyrazinamide
rpsA 1833283 c.-259C>G upstream_gene_variant 0.21 pyrazinamide
rpsA 1833295 c.-247C>G upstream_gene_variant 0.22 pyrazinamide
rpsA 1833298 c.-244G>A upstream_gene_variant 0.21 pyrazinamide
rpsA 1833310 c.-232T>C upstream_gene_variant 0.19 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.16 pyrazinamide Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.26 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833610 c.69C>A synonymous_variant 0.19 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833664 c.123C>A synonymous_variant 0.2 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.2 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1833718 c.177C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.36 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.19 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.35 pyrazinamide
rpsA 1833754 c.213G>A synonymous_variant 0.18 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1833782 p.Ser81Thr missense_variant 0.16 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.16 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.33 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833850 c.309C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.34 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.35 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.19 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.23 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833934 c.393C>T synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1833949 c.408T>C synonymous_variant 0.36 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.17 pyrazinamide
rpsA 1834024 c.483G>A synonymous_variant 0.19 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.29 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.3 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834249 c.708T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834306 c.765T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.23 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.23 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.24 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834615 c.1074C>T synonymous_variant 0.27 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.19 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.25 pyrazinamide
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.23 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.27 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.28 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.29 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.21 linezolid
tsnR 1853477 c.-129T>C upstream_gene_variant 0.17 linezolid
tsnR 1853574 c.-32T>C upstream_gene_variant 1.0 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1917975 c.36C>G synonymous_variant 0.17 capreomycin
tlyA 1917981 c.42G>C synonymous_variant 0.17 capreomycin
tlyA 1917987 c.48G>C synonymous_variant 0.18 capreomycin
tlyA 1917996 c.57A>C synonymous_variant 0.2 capreomycin
tlyA 1918002 p.Gln21His missense_variant 0.16 capreomycin
tlyA 1918008 c.69C>T synonymous_variant 0.15 capreomycin
bacA 2063523 c.1206T>C synonymous_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
bacA 2063529 c.1200A>G synonymous_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
bacA 2063538 c.1191A>G synonymous_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2063541 c.1188A>G synonymous_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2063550 c.1179C>G synonymous_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
bacA 2063658 c.1071A>G synonymous_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
bacA 2063667 c.1062G>A synonymous_variant 0.2 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
streptomycin
amikacin
bacA 2063676 c.1053C>G synonymous_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
bacA 2063697 c.1032A>G synonymous_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
bacA 2063703 c.1026C>T synonymous_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
bacA 2063715 c.1014T>C synonymous_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2063724 c.1005T>C synonymous_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2063730 c.999A>T synonymous_variant 0.19 kanamycin
capreomycin
streptomycin
amikacin
bacA 2063742 c.987G>C synonymous_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
ndh 2101939 c.1104A>C synonymous_variant 0.19 isoniazid
delamanid
ethionamide
ndh 2101980 p.Asn355Asp missense_variant 0.23 isoniazid
delamanid
ethionamide
ndh 2101987 c.1056C>G synonymous_variant 0.19 isoniazid
delamanid
ethionamide
ndh 2101990 c.1053G>C synonymous_variant 0.25 isoniazid
delamanid
ethionamide
ndh 2101999 c.1044G>A synonymous_variant 0.26 isoniazid Not assoc w R - Interim
delamanid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
ndh 2102020 c.1023A>G synonymous_variant 0.23 isoniazid
delamanid
ethionamide
ndh 2102023 c.1020G>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
delamanid
ethionamide
ndh 2102026 c.1017G>T synonymous_variant 0.18 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155649 p.Tyr155His missense_variant 0.15 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.16 isoniazid
kasA 2518283 p.Ala57Pro missense_variant 0.18 isoniazid
kasA 2518297 c.183C>T synonymous_variant 0.17 isoniazid
kasA 2518312 c.198T>C synonymous_variant 0.15 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.19 isoniazid
kasA 2518534 c.420G>C synonymous_variant 0.18 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.21 isoniazid
kasA 2518567 c.453G>T synonymous_variant 0.18 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.16 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.18 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.17 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.23 isoniazid
kasA 2518645 c.531G>C synonymous_variant 0.17 isoniazid
kasA 2518648 c.534C>T synonymous_variant 0.15 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.32 isoniazid
kasA 2518681 c.567C>T synonymous_variant 0.19 isoniazid
kasA 2518684 c.570C>A synonymous_variant 0.22 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.36 isoniazid
kasA 2518717 c.603C>G synonymous_variant 0.21 isoniazid
kasA 2518735 c.621C>A synonymous_variant 0.16 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.32 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.18 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.31 isoniazid
kasA 2518789 c.675G>T synonymous_variant 0.2 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.26 isoniazid
kasA 2518798 c.684G>C synonymous_variant 0.19 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.2 isoniazid
kasA 2518822 c.708C>T synonymous_variant 0.16 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.22 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.16 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.23 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.27 isoniazid
kasA 2518894 c.780G>A synonymous_variant 0.18 isoniazid
kasA 2518903 c.789C>T synonymous_variant 0.18 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.29 isoniazid
kasA 2518910 c.796C>T synonymous_variant 0.22 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.21 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.21 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.21 isoniazid
ahpC 2726354 c.162G>C synonymous_variant 0.2 isoniazid
ahpC 2726357 c.165A>G synonymous_variant 0.2 isoniazid Not assoc w R - Interim
ahpC 2726366 c.174G>C synonymous_variant 0.24 isoniazid
ahpC 2726378 c.186T>G synonymous_variant 0.19 isoniazid
ahpC 2726393 c.201G>C synonymous_variant 0.21 isoniazid
ahpC 2726397 p.Ser69Gly missense_variant 0.19 isoniazid
ahpC 2726408 c.216T>C synonymous_variant 0.19 isoniazid
ahpC 2726430 p.Ala80Thr missense_variant 0.17 isoniazid
folC 2746657 c.942T>C synonymous_variant 0.18 para-aminosalicylic_acid
folC 2746663 c.936T>C synonymous_variant 0.18 para-aminosalicylic_acid
Rv2477c 2783194 c.849A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783425 p.Pro206Ala missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin
Rv2477c 2783428 c.615C>T synonymous_variant 0.26 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783449 c.594C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783512 c.531A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>A synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783935 c.108C>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783950 c.93C>T synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783956 p.Tyr29Phe missense_variant 0.35 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783967 c.76T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.4 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.3 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2784016 c.27G>A synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784519 c.-477G>A upstream_gene_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784525 c.-483G>A upstream_gene_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
pepQ 2859468 c.951G>T synonymous_variant 0.25 bedaquiline
clofazimine
pepQ 2859489 p.Val310Ala missense_variant 0.25 bedaquiline
clofazimine
pepQ 2859510 c.909T>C synonymous_variant 0.23 bedaquiline
clofazimine
pepQ 2859528 c.891T>C synonymous_variant 0.21 bedaquiline
clofazimine
pepQ 2859540 c.879A>T synonymous_variant 0.18 bedaquiline
clofazimine
Rv2752c 3064596 c.1596G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3064602 c.1590T>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065556 c.636G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065580 c.612G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065583 c.609G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065595 p.Leu199Phe missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065612 p.Thr194Ala missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065634 c.558G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065640 c.552T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065947 p.Gly82Ala missense_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067280 c.666G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067284 p.Ala221Asp missense_variant 0.17 para-aminosalicylic_acid
thyX 3067295 c.651C>T synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067850 c.96A>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067886 c.60A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.21 para-aminosalicylic_acid
thyA 3073932 c.540C>T synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.18 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.18 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 0.99 pyrazinamide Not assoc w R - Interim
lpqB 3623468 c.1443T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3623471 c.1440C>T synonymous_variant 0.16 rifampicin
bedaquiline
lpqB 3623489 c.1422C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3623492 c.1419T>C synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3623510 c.1401C>T synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624041 p.Glu290Asp missense_variant 0.16 rifampicin
bedaquiline
lpqB 3624071 c.840C>T synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624080 c.831G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624094 c.817A>C synonymous_variant 0.16 rifampicin
bedaquiline
lpqB 3624098 c.813G>A synonymous_variant 0.16 rifampicin
bedaquiline
lpqB 3624101 c.810C>A synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624107 c.804C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624356 c.555C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624389 c.522C>G synonymous_variant 0.16 rifampicin
bedaquiline
lpqB 3624406 c.505C>T synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624422 c.489G>C synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624425 p.Glu162Ala missense_variant 0.18 rifampicin
bedaquiline
lpqB 3624428 c.483A>G synonymous_variant 0.19 rifampicin
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3625161 c.-251T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625186 c.-276T>G upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625195 c.-285A>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625222 c.1392T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625243 c.-333T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
lpqB 3625255 c.-345T>G upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625648 c.-738T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625663 c.-753G>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625684 c.-774G>A upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625747 c.-837G>T upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.2 rifampicin Uncertain significance
bedaquiline
lpqB 3625804 c.-896_-894delAGGinsCGA upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 0.98 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626684 c.-71G>T upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626702 c.-91_-89delCTGinsTTA upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626776 c.-163A>C upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626852 c.-239G>A upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3626857 c.-244T>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3626876 c.-263A>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626954 c.-341C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626981 c.-368C>T upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626990 c.-377G>A upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627002 c.-389G>A upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627011 c.-398T>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627071 c.-458G>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627140 c.-527G>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627155 c.-542C>T upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.31 rifampicin
bedaquiline
mtrA 3627187 c.163T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627190 c.160T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627203 c.-590C>G upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627287 c.-674C>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627296 c.-683T>A upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3627301 c.-688T>C upstream_gene_variant 0.19 rifampicin
bedaquiline
rpoA 3877557 c.951C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.26 rifampicin
rpoA 3877668 c.840A>G synonymous_variant 0.21 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.15 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.21 rifampicin
rpoA 3877755 c.753C>A synonymous_variant 0.17 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877830 c.678C>T synonymous_variant 0.21 rifampicin
rpoA 3877836 c.672A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.25 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.26 rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.26 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.35 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877929 c.579C>T synonymous_variant 0.15 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.35 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877995 c.513G>A synonymous_variant 0.22 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.25 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.24 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.25 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.25 rifampicin
rpoA 3878043 c.465G>C synonymous_variant 0.21 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.17 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.23 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.25 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.25 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.27 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.17 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>C synonymous_variant 0.21 rifampicin
rpoA 3878211 c.297G>A synonymous_variant 0.21 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.17 rifampicin Uncertain significance
rpoA 3878295 c.213A>G synonymous_variant 0.2 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878406 c.102G>T synonymous_variant 0.21 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.16 rifampicin
rpoA 3878421 c.87A>T synonymous_variant 0.19 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.27 rifampicin
rpoA 3878454 c.54A>G synonymous_variant 0.25 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.26 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.22 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.17 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.19 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.28 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.22 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3879022 c.-515G>C upstream_gene_variant 0.17 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.23 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.25 rifampicin
rpoA 3879148 c.-641G>C upstream_gene_variant 0.16 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.28 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.3 rifampicin
rpoA 3879172 c.-665C>T upstream_gene_variant 0.2 rifampicin
rpoA 3879184 c.-677G>A upstream_gene_variant 0.17 rifampicin
ddn 3986648 c.-196C>G upstream_gene_variant 0.15 pretomanid
delamanid
clpC1 4038278 c.2427T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038314 c.2391T>G synonymous_variant 0.19 pyrazinamide
clpC1 4038335 c.2370C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038344 c.2361G>A synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038350 c.2355C>G synonymous_variant 0.3 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.29 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038407 c.2298G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038436 p.Ala757Ser missense_variant 0.17 pyrazinamide
clpC1 4038445 p.Ala754Thr missense_variant 0.16 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.15 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.27 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.28 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038800 c.1905C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.19 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.37 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039337 c.1368A>C synonymous_variant 0.26 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039391 c.1314T>G synonymous_variant 0.24 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039715 c.990G>A synonymous_variant 0.19 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039727 c.978C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039796 c.909C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>T synonymous_variant 0.25 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.27 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040033 c.672G>C synonymous_variant 0.29 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040551 c.154T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.19 pyrazinamide
glpK 4139231 c.525A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4238909 c.-954C>G upstream_gene_variant 0.15 ethambutol
embC 4238912 c.-951C>T upstream_gene_variant 0.15 ethambutol
embC 4238943 c.-920G>A upstream_gene_variant 0.17 ethambutol Uncertain significance
embC 4238954 c.-909C>T upstream_gene_variant 0.2 ethambutol
embC 4238963 c.-900C>T upstream_gene_variant 0.19 ethambutol Not assoc w R
embC 4238969 c.-894A>G upstream_gene_variant 0.2 ethambutol
embC 4238972 c.-891C>G upstream_gene_variant 0.21 ethambutol Uncertain significance
embC 4238975 c.-888A>C upstream_gene_variant 0.21 ethambutol
embC 4238986 c.-877C>A upstream_gene_variant 0.15 ethambutol
embC 4239032 c.-831T>C upstream_gene_variant 0.15 ethambutol Uncertain significance
embC 4239089 c.-774C>G upstream_gene_variant 0.18 ethambutol
embC 4239125 c.-738C>G upstream_gene_variant 0.21 ethambutol
embC 4239141 c.-722G>A upstream_gene_variant 0.18 ethambutol Uncertain significance
embC 4239147 c.-716T>C upstream_gene_variant 0.17 ethambutol
embC 4239378 c.-485T>C upstream_gene_variant 0.17 ethambutol
embC 4240475 p.Ala205Ser missense_variant 0.15 ethambutol Uncertain significance
embC 4240486 c.624G>A synonymous_variant 0.24 ethambutol
embC 4240489 c.627A>G synonymous_variant 0.23 ethambutol
embC 4240495 c.633T>C synonymous_variant 0.23 ethambutol
embC 4240512 p.Ser217Thr missense_variant 0.2 ethambutol
embC 4240516 c.654G>C synonymous_variant 0.2 ethambutol
embC 4240519 c.657T>C synonymous_variant 0.2 ethambutol
embC 4240717 c.855T>C synonymous_variant 0.21 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4240741 c.879C>T synonymous_variant 0.21 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.22 ethambutol
embC 4240795 c.933C>G synonymous_variant 0.16 ethambutol
embC 4240859 p.Leu333Met missense_variant 0.18 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.18 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.18 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.17 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.16 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.16 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.17 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.22 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.22 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4241153 p.Ile431Leu missense_variant 0.22 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.26 ethambutol
embC 4241167 c.1305C>G synonymous_variant 0.2 ethambutol
embC 4241185 c.1323G>C synonymous_variant 0.19 ethambutol
embC 4242139 c.2277G>C synonymous_variant 0.15 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242791 p.Ala977Ser missense_variant 0.16 ethambutol
embA 4243460 c.228C>T synonymous_variant 0.97 ethambutol Not assoc w R
embA 4244823 p.Val531Met missense_variant 0.16 ethambutol
embA 4244856 p.Ala542Pro missense_variant 0.2 ethambutol
embA 4244885 c.1653A>G synonymous_variant 0.23 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.21 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.23 ethambutol
embA 4245149 c.1917C>A synonymous_variant 0.19 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.17 ethambutol
embA 4245174 p.Ser648Thr missense_variant 0.18 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.24 ethambutol
embA 4245186 p.Thr652Ala missense_variant 0.23 ethambutol
embA 4245200 c.1968C>G synonymous_variant 0.17 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.17 ethambutol
embB 4245620 c.-894T>C upstream_gene_variant 0.22 ethambutol
embB 4245623 c.-891G>A upstream_gene_variant 0.21 ethambutol
embB 4245662 c.-852G>C upstream_gene_variant 0.23 ethambutol
embA 4245674 c.2442A>T synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4245677 c.-837G>C upstream_gene_variant 0.24 ethambutol
embB 4245683 c.-831C>T upstream_gene_variant 0.26 ethambutol
embA 4245693 p.Ile821Val missense_variant 0.25 ethambutol
embB 4245714 c.-800C>T upstream_gene_variant 0.21 ethambutol
embB 4245725 c.-789A>G upstream_gene_variant 0.16 ethambutol
embB 4245726 c.-788T>C upstream_gene_variant 0.18 ethambutol
embB 4246346 c.-168C>G upstream_gene_variant 0.21 ethambutol
embA 4246359 p.Ala1043Ser missense_variant 0.19 ethambutol
embB 4246567 c.54G>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247446 c.933C>T synonymous_variant 0.17 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.33 ethambutol
embB 4247494 c.981G>A synonymous_variant 0.2 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.33 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.34 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.3 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.25 ethambutol
embB 4247590 c.1077A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247858 c.1345C>T synonymous_variant 0.19 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.24 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.15 ethambutol
embB 4248055 c.1542G>C synonymous_variant 0.23 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.26 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.27 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.26 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.2 ethambutol
embB 4248154 c.1641G>T synonymous_variant 0.22 ethambutol
embB 4248157 c.1644A>T synonymous_variant 0.22 ethambutol
embB 4248163 c.1650G>A synonymous_variant 0.2 ethambutol
embB 4248169 c.1656C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4248175 c.1662G>A synonymous_variant 0.19 ethambutol
embB 4248178 c.1665C>T synonymous_variant 0.19 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.21 ethambutol Uncertain significance
embB 4248217 c.1704C>G synonymous_variant 0.2 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248233 c.1720C>T synonymous_variant 0.2 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.27 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.28 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.27 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.27 ethambutol
embB 4248349 c.1836G>A synonymous_variant 0.16 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.16 ethambutol
embB 4248379 c.1866G>A synonymous_variant 0.15 ethambutol
embB 4248706 c.2193G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248731 p.Val740Leu missense_variant 0.17 ethambutol
embB 4249568 p.Ser1019Asn missense_variant 0.18 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.17 ethambutol
aftB 4267556 c.1281G>C synonymous_variant 0.17 ethambutol
aftB 4267574 c.1263G>C synonymous_variant 0.19 ethambutol
aftB 4267580 c.1257G>A synonymous_variant 0.19 ethambutol
aftB 4267592 c.1245C>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
aftB 4267622 p.Ser405Thr missense_variant 0.2 ethambutol
aftB 4267634 p.Arg401His missense_variant 0.19 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.79 ethambutol Not assoc w R
aftB 4269000 c.-164G>A upstream_gene_variant 0.19 ethambutol
aftB 4269006 c.-170T>C upstream_gene_variant 0.2 ethambutol
aftB 4269012 c.-176G>C upstream_gene_variant 0.2 ethambutol
aftB 4269033 c.-197T>C upstream_gene_variant 0.18 ethambutol
aftB 4269195 c.-359C>T upstream_gene_variant 0.17 ethambutol
ubiA 4269222 c.612T>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
ubiA 4269225 c.609C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
aftB 4269231 c.-395C>T upstream_gene_variant 0.16 ethambutol
aftB 4269234 c.-398A>G upstream_gene_variant 0.26 ethambutol
ubiA 4269243 p.His197Gln missense_variant 0.23 ethambutol
aftB 4269248 c.-412C>T upstream_gene_variant 0.22 ethambutol
aftB 4269285 c.-449T>G upstream_gene_variant 0.16 ethambutol
ethA 4326535 c.939G>C synonymous_variant 0.16 ethionamide
ethR 4326556 c.-993A>G upstream_gene_variant 0.15 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R