TB-Profiler result

Run: SRR12708389
Summary

Run ID: SRR12708389

Sample name:

Date: 2024-04-15T22:28:43.806120

Number of reads: 1214983

Percentage reads mapped: 70.27

Median coverage: 36.0

Strain: lineage4.8.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 0.99
lineage4.8 Euro-American (mainly T) RD219 0.97
lineage4.8.1 Euro-American (mainly T) RD219 0.96
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Asp435Val Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Val Assoc w R
p.His312Arg Mutation from literature
pyrazinamide pncA p.Leu151Ser Assoc w R
streptomycin rpsL p.Lys43Arg Assoc w R
rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761110 p.Asp435Val missense_variant 0.59 rifampicin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 0.63 streptomycin Assoc w R
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance Mutation from literature
katG 2155168 p.Ser315Thr missense_variant 0.95 isoniazid Assoc w R High-level resistance
pncA 2288790 p.Leu151Ser missense_variant 0.97 pyrazinamide Assoc w R
embB 4247429 p.Met306Val missense_variant 0.63 ethambutol Assoc w R
embB 4247448 p.His312Arg missense_variant 0.37 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 708 c.708T>C synonymous_variant 0.15 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.16 isoniazid
dnaA 942 c.942C>G synonymous_variant 0.2 isoniazid
dnaA 945 c.945G>A synonymous_variant 0.2 isoniazid
dnaA 955 c.955A>C synonymous_variant 0.2 isoniazid
dnaA 960 c.960C>A synonymous_variant 0.17 isoniazid
dnaA 963 c.963C>G synonymous_variant 0.17 isoniazid
dnaA 966 c.966T>C synonymous_variant 0.17 isoniazid
dnaA 969 c.969G>A synonymous_variant 0.19 isoniazid
dnaA 975 c.975G>T synonymous_variant 0.2 isoniazid
dnaA 984 c.984T>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 993 c.993A>G synonymous_variant 0.23 isoniazid
dnaA 996 c.996A>G synonymous_variant 0.21 isoniazid
dnaA 999 c.999C>G synonymous_variant 0.23 isoniazid
dnaA 1003 c.1003C>T synonymous_variant 0.23 isoniazid
dnaA 1008 c.1008G>A synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 1014 c.1014C>G synonymous_variant 0.25 isoniazid
dnaA 1024 c.1024T>C synonymous_variant 0.26 isoniazid
dnaA 1038 c.1038A>T synonymous_variant 0.16 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.23 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.23 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.23 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.22 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.22 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.26 isoniazid
dnaA 1137 c.1137C>G synonymous_variant 0.25 isoniazid
dnaA 1143 c.1143G>C synonymous_variant 0.24 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.25 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.25 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.24 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.26 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.28 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.28 isoniazid
dnaA 1254 c.1254T>C synonymous_variant 0.22 isoniazid
dnaA 1353 c.1353T>C synonymous_variant 0.16 isoniazid
dnaA 1371 c.1371T>G synonymous_variant 0.19 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.17 isoniazid
dnaA 1389 c.1389C>G synonymous_variant 0.18 isoniazid
dnaA 1392 c.1392A>G synonymous_variant 0.17 isoniazid
dnaA 1395 c.1395G>C synonymous_variant 0.18 isoniazid
dnaA 1404 c.1404T>C synonymous_variant 0.17 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.17 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.18 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.18 isoniazid
dnaA 1428 c.1428C>G synonymous_variant 0.18 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.18 isoniazid
gyrB 6238 c.999G>A synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrB 6265 c.1026C>T synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 6304 c.-998C>G upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.39 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.4 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.42 levofloxacin
moxifloxacin
gyrA 6376 c.-926G>A upstream_gene_variant 0.34 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.3 levofloxacin
moxifloxacin
gyrA 6403 c.-899T>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrA 6634 c.-668T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6637 c.-665T>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6640 c.-662A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6649 c.-653T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6655 c.-647T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.25 levofloxacin Uncertain significance
moxifloxacin
gyrA 6742 c.-560A>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6751 c.-551G>C upstream_gene_variant 0.28 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.27 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6775 c.1536G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.19 levofloxacin
moxifloxacin
gyrB 6811 c.1572C>T synonymous_variant 0.2 levofloxacin
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6916 c.-386G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6919 c.1680T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6925 c.-377T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 6931 c.1692A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6949 c.-353A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6952 c.1713C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6967 c.-335T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6973 c.-329G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6982 c.-320A>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7007 c.-295C>T upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 7010 c.-292C>T upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 7023 p.Leu595Gln missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7165 c.-137C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7562 c.261C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7571 c.270G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 0.24 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7601 c.300C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7625 c.324G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7683 c.382_384delAGGinsCC frameshift_variant&missense_variant 0.27 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7697 c.396C>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCT frameshift_variant&missense_variant 0.26 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7793 c.492G>C synonymous_variant 0.34 levofloxacin
moxifloxacin
gyrA 7796 c.495G>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7823 c.522G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7832 c.531G>T synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7835 c.534A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7853 c.552C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7859 c.558A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8234 c.933T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8247 c.946_948delATCinsGG frameshift_variant&missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8276 c.975G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8330 c.1029C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8337 c.1036_1038delCTAinsTG frameshift_variant&stop_gained 0.15 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8543 c.1242C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8553 c.1252C>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8588 c.1287G>A synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8678 c.1377G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8696 c.1395G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8699 c.1398A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8708 c.1407G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8818 p.Ser506Asn missense_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8828 c.1527T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8891 c.1590G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.23 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9153 p.Thr618Glu missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.28 levofloxacin
moxifloxacin
gyrA 9218 c.1917C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9227 c.1926C>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 9267 p.Asn656Gly missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9435 c.2134C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9443 c.2142G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9452 c.2151G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
fgd1 491620 p.Ile280Val missense_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491643 c.861G>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491646 c.864G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491649 c.867C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
mshA 575719 c.372C>T synonymous_variant 0.16 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575884 c.537G>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575887 c.540G>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575893 c.546C>G synonymous_variant 0.28 ethionamide
isoniazid
mshA 575896 c.549G>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575908 c.561A>G synonymous_variant 0.29 ethionamide
isoniazid
mshA 575917 p.Asp190Glu missense_variant 0.26 ethionamide
isoniazid
mshA 575920 c.573C>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575924 p.Gly193Ser missense_variant 0.24 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.21 ethionamide
isoniazid
mshA 575950 c.603C>G synonymous_variant 0.23 ethionamide
isoniazid
ccsA 620310 c.420C>T synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620646 c.756G>A synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620649 c.759A>G synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620659 c.769_771delCGCinsAG frameshift_variant&missense_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620664 c.774C>T synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.39 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.4 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAA frameshift_variant&missense_variant 0.41 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.32 capreomycin
amikacin
kanamycin
Rv0565c 656192 p.Asp427Asn missense_variant 0.19 ethionamide Uncertain significance
Rv0565c 656196 p.Leu425Arg missense_variant 0.18 ethionamide
Rv0565c 656219 p.His418Tyr missense_variant 0.18 ethionamide
Rv0565c 656220 c.1251A>C synonymous_variant 0.18 ethionamide
Rv0565c 656223 c.1248T>C synonymous_variant 0.19 ethionamide Not assoc w R - Interim
Rv0565c 656226 c.1243_1245delGCCinsTT frameshift_variant&missense_variant 0.19 ethionamide Uncertain significance
Rv0565c 656238 p.Ala411Glu missense_variant 0.19 ethionamide
Rv0565c 656243 p.Leu410Met missense_variant 0.18 ethionamide
Rv0565c 656244 c.1227A>C synonymous_variant 0.17 ethionamide
Rv0565c 656391 c.1080C>G synonymous_variant 0.18 ethionamide
Rv0565c 656402 p.Ala357Thr missense_variant 0.19 ethionamide
Rv0565c 656412 c.1059T>G synonymous_variant 0.19 ethionamide
Rv0565c 656418 c.1053A>G synonymous_variant 0.19 ethionamide
Rv0565c 657300 c.171C>G synonymous_variant 0.22 ethionamide
Rv0565c 657303 c.168C>T synonymous_variant 0.22 ethionamide Not assoc w R - Interim
Rv0565c 657318 c.153T>C synonymous_variant 0.21 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.19 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.2 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.2 ethionamide Uncertain significance
Rv0565c 657342 c.129T>C synonymous_variant 0.18 ethionamide
Rv0565c 657347 c.124A>C synonymous_variant 0.2 ethionamide
Rv0565c 657348 c.123A>G synonymous_variant 0.19 ethionamide
Rv0565c 657356 p.Ile39Val missense_variant 0.19 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.23 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.24 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.23 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.26 ethionamide
hadA 731682 c.-248C>G upstream_gene_variant 0.25 isoniazid
hadA 731687 c.-243_-242insCACAGATCTTTT upstream_gene_variant 0.23 isoniazid
hadA 731693 c.-237C>A upstream_gene_variant 0.24 isoniazid
hadA 731696 c.-233_-232delTT upstream_gene_variant 0.24 isoniazid
hadA 731708 c.-222G>C upstream_gene_variant 0.26 isoniazid
hadA 731710 c.-220A>T upstream_gene_variant 0.25 isoniazid
hadA 731711 c.-219T>C upstream_gene_variant 0.25 isoniazid
hadA 731717 c.-213T>G upstream_gene_variant 0.27 isoniazid
hadA 731732 c.-198G>A upstream_gene_variant 0.29 isoniazid
hadA 731747 c.-183T>C upstream_gene_variant 0.33 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.21 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.21 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.22 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.22 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.26 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.27 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.27 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.22 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.21 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.21 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.25 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.27 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.29 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.27 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.29 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.29 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.3 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.29 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.29 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.28 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.27 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.29 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.3 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.27 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.25 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.3 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.25 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.3 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>T synonymous_variant 0.25 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.24 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.24 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.28 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.33 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.38 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.39 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.36 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.38 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.4 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.46 rifampicin
rpoB 761312 c.1506G>C synonymous_variant 0.47 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.39 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.33 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.29 rifampicin
rpoB 761373 p.Val523His missense_variant 0.25 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.17 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.3 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.29 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.27 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.29 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.31 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.28 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.28 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.28 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.26 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.25 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.25 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.23 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.21 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.22 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.23 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.2 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.26 rifampicin
rpoC 762401 c.-969G>C upstream_gene_variant 0.23 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.23 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762419 c.-951C>G upstream_gene_variant 0.25 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.26 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.27 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.25 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.18 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.19 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.19 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.17 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.17 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.17 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.19 rifampicin
rpoC 762758 c.-612G>C upstream_gene_variant 0.17 rifampicin
rpoB 762782 c.2976T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762785 p.Asp993Glu missense_variant 0.21 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.21 rifampicin Uncertain significance
rpoC 762794 c.-576C>G upstream_gene_variant 0.23 rifampicin
rpoB 762799 p.Ala998Gly missense_variant 0.24 rifampicin Uncertain significance
rpoB 762810 c.3004_3006delGCCinsTG frameshift_variant&missense_variant 0.23 rifampicin
rpoB 762813 p.Met1003Val missense_variant 0.23 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762926 c.3120C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.23 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.27 rifampicin
rpoC 763025 c.-345C>T upstream_gene_variant 0.29 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.22 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.23 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.16 rifampicin
rpoC 763402 c.33C>G synonymous_variant 0.19 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.21 rifampicin
rpoC 763441 c.72C>T synonymous_variant 0.28 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.34 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.28 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.31 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.32 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.34 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.34 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.31 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.33 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.29 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.24 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.21 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.19 rifampicin
rpoC 763963 c.594C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763987 c.618C>T synonymous_variant 0.26 rifampicin
rpoC 763991 c.622_624delATCinsCG frameshift_variant&missense_variant 0.24 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.26 rifampicin
rpoC 764002 c.633C>G synonymous_variant 0.24 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764024 c.655_657delTTGinsCC frameshift_variant&missense_variant 0.23 rifampicin
rpoC 764032 p.Asp221Glu missense_variant 0.23 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.16 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.27 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.24 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.24 rifampicin
rpoC 764272 c.903G>C synonymous_variant 0.24 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764381 p.Ser338Thr missense_variant 0.16 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.18 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.2 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.19 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.18 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.22 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.23 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.35 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.32 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.22 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 765478 c.2109T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.31 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.28 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.29 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.3 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.32 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.29 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.31 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.45 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.48 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.43 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.42 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.44 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.44 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.46 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.45 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.46 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.44 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.32 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.28 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.25 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.24 rifampicin
rpoC 766030 c.2661C>G synonymous_variant 0.25 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.29 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.29 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.2 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.21 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766327 c.2958C>A synonymous_variant 0.19 rifampicin
rpoC 766345 c.2976T>C synonymous_variant 0.22 rifampicin
rpoC 766348 c.2979A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766357 c.2988C>T synonymous_variant 0.25 rifampicin
rpoC 766363 c.2994G>C synonymous_variant 0.27 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.28 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.27 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.3 rifampicin
rpoC 766408 c.3039C>G synonymous_variant 0.33 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.33 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.36 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.34 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.34 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.31 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.31 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.31 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.3 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.28 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.29 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.31 rifampicin
rpoC 766549 c.3180G>T synonymous_variant 0.33 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.29 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.27 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.27 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.28 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.29 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.3 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.31 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.26 rifampicin
rpoC 766660 c.3291G>C synonymous_variant 0.27 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.38 rifampicin
rpoC 766876 c.3507C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766882 c.3513C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.39 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.39 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.4 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.42 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.38 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.26 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.28 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.24 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.35 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.44 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.25 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.19 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777116 c.1365C>T synonymous_variant 0.16 clofazimine
bedaquiline
mmpL5 777133 p.Val450Ile missense_variant 0.19 clofazimine
bedaquiline
mmpL5 777158 c.1323C>G synonymous_variant 0.21 clofazimine
bedaquiline
mmpL5 777164 c.1317C>G synonymous_variant 0.22 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.3 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.31 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.35 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.37 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.35 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.36 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.4 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.41 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.35 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.31 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.32 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.33 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.35 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.34 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.29 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.29 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.25 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.25 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.23 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.27 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.28 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.28 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.3 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.33 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.35 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.33 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.33 streptomycin Uncertain significance
rplC 800537 c.-272C>T upstream_gene_variant 0.26 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.28 linezolid
rplC 800546 c.-263T>G upstream_gene_variant 0.31 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.3 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.36 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.38 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.36 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.44 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.45 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.43 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.36 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.33 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.32 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.31 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.31 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.27 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.22 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.17 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.18 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.18 linezolid
rplC 800814 c.6A>G synonymous_variant 0.18 linezolid
rplC 800817 c.9A>T synonymous_variant 0.18 linezolid
rplC 800844 c.36T>C synonymous_variant 0.24 linezolid
rplC 801147 c.339T>C synonymous_variant 0.18 linezolid
rplC 801150 c.342G>C synonymous_variant 0.19 linezolid
rplC 801153 c.345G>C synonymous_variant 0.19 linezolid
rplC 801156 c.348T>A synonymous_variant 0.19 linezolid
rplC 801168 c.360C>G synonymous_variant 0.17 linezolid
rplC 801171 c.363A>G synonymous_variant 0.17 linezolid
rplC 801174 c.366T>C synonymous_variant 0.21 linezolid
rplC 801195 c.387G>C synonymous_variant 0.26 linezolid
rplC 801207 c.399C>T synonymous_variant 0.27 linezolid
rplC 801246 c.438C>T synonymous_variant 0.29 linezolid
rplC 801249 c.441T>C synonymous_variant 0.29 linezolid
rplC 801255 c.447C>T synonymous_variant 0.28 linezolid
rplC 801264 c.456C>T synonymous_variant 0.24 linezolid
rplC 801267 c.459A>T synonymous_variant 0.21 linezolid
rplC 801270 c.462T>C synonymous_variant 0.2 linezolid
rplC 801276 c.468G>C synonymous_variant 0.2 linezolid
rplC 801279 c.471G>C synonymous_variant 0.2 linezolid
rplC 801282 c.474G>C synonymous_variant 0.2 linezolid
rplC 801285 c.477G>C synonymous_variant 0.21 linezolid
rplC 801300 c.492C>G synonymous_variant 0.21 linezolid
rplC 801309 c.501C>G synonymous_variant 0.21 linezolid
rplC 801339 c.531T>C synonymous_variant 0.18 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.17 linezolid
rplC 801348 c.540T>G synonymous_variant 0.19 linezolid
rplC 801357 c.549T>C synonymous_variant 0.2 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.23 linezolid
rplC 801402 c.594T>C synonymous_variant 0.27 linezolid
rplC 801405 c.597T>C synonymous_variant 0.26 linezolid
rplC 801423 c.615G>C synonymous_variant 0.26 linezolid
fbiC 1304535 c.1605G>A synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.28 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304862 c.1932G>A synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305030 c.2100G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
atpE 1461185 c.141G>T synonymous_variant 0.22 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.22 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.15 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.35 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.635_649delTTCCTCTCCGGAGGA non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.43 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.4 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476031 n.2374C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476048 n.2391G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476214 n.2557G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.3 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.32 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1476755 n.3098G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
inhA 1673679 c.-523T>C upstream_gene_variant 0.2 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1673685 c.-517C>T upstream_gene_variant 0.22 ethionamide
isoniazid
fabG1 1673710 p.Leu91Ile missense_variant 0.22 ethionamide
isoniazid
fabG1 1673716 p.Ala93Lys missense_variant 0.24 ethionamide
isoniazid
fabG1 1673733 p.Met98Ile missense_variant 0.25 ethionamide
isoniazid
inhA 1673748 c.-454A>G upstream_gene_variant 0.24 ethionamide
isoniazid
fabG1 1673749 p.Lys104Arg missense_variant 0.24 ethionamide
isoniazid
fabG1 1673758 p.Lys107Glu missense_variant 0.23 ethionamide
isoniazid
inhA 1674504 c.303C>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674507 c.306G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.23 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.25 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.26 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.23 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.25 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.28 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.27 ethionamide
isoniazid
inhA 1674864 c.663C>T synonymous_variant 0.2 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.21 ethionamide
isoniazid
rpsA 1833661 c.120A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.21 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.27 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.26 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.33 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.33 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834262 c.721_723delTCGinsAGC synonymous_variant 0.22 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834513 c.972C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834555 c.1014T>G synonymous_variant 0.21 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.16 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.15 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.19 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.22 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.2 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.19 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.33 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.34 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.34 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.31 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.31 linezolid
tsnR 1853423 c.-183C>T upstream_gene_variant 0.3 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.28 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.27 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.23 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.19 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.19 linezolid
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2101804 c.1239T>G synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2101808 p.Thr412Ser missense_variant 0.24 ethionamide
delamanid
isoniazid
PPE35 2168149 p.Pro822Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2170892 c.-280G>A upstream_gene_variant 1.0 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518540 c.426T>C synonymous_variant 0.17 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.17 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.17 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.19 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.22 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.22 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.28 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.3 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.3 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.28 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.27 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.26 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.2 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.21 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.23 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.25 isoniazid
kasA 2519050 c.936C>G synonymous_variant 0.3 isoniazid
kasA 2519053 c.939G>C synonymous_variant 0.28 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.26 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.25 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.25 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.17 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.18 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.26 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.19 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.17 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.17 isoniazid Not assoc w R - Interim
ahpC 2726675 c.483A>G synonymous_variant 0.17 isoniazid
ahpC 2726681 c.489A>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
folC 2747335 c.264G>C synonymous_variant 0.22 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.16 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.18 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.17 para-aminosalicylic_acid
Rv2477c 2782912 p.Ser377Thr missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782966 c.1077C>A synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.27 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783048 p.Asp332Gly missense_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.25 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin
amikacin Not assoc w R - Interim
Rv2477c 2783149 c.894G>C synonymous_variant 0.23 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783179 c.864G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783182 c.861C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783209 c.834G>A synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783275 c.768C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 c.750G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783311 c.732T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783314 c.729C>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783317 c.726G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783557 c.486T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2680 2995848 c.-257G>A upstream_gene_variant 1.0 capreomycin
Rv2752c 3066009 c.183G>C synonymous_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.24 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066582 c.-392_-391delCCinsGG upstream_gene_variant 0.21 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067316 c.630A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.25 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.29 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.29 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.28 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.27 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.26 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067583 c.363C>G synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.33 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.35 para-aminosalicylic_acid
thyA 3073917 c.555C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073920 c.552C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.21 para-aminosalicylic_acid
fbiD 3339040 c.-78T>C upstream_gene_variant 1.0 clofazimine
pretomanid
delamanid
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance
lpqB 3624688 p.Glu75Gln missense_variant 0.19 bedaquiline
rifampicin
lpqB 3624728 c.183C>T synonymous_variant 0.2 bedaquiline
rifampicin
mtrB 3625149 p.Val489Ile missense_variant 0.17 bedaquiline
rifampicin
lpqB 3625161 c.-251T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625162 c.1452T>C synonymous_variant 0.21 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625165 c.-255G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.21 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.26 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626876 c.-263A>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.33 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626957 c.-344G>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626972 c.-359A>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626987 c.-374C>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.34 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.28 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.31 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
fbiB 3642874 p.Leu447Arg missense_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
rpoA 3877587 c.921A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.31 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.34 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.35 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.32 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.19 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.32 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.31 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.31 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.3 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.34 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.32 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.31 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877909 p.Asn200Ser missense_variant 0.3 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.22 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878181 c.327C>T synonymous_variant 0.19 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.19 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.26 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878226 c.282C>G synonymous_variant 0.33 rifampicin
rpoA 3878232 c.276G>C synonymous_variant 0.33 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.38 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.42 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.4 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoA 3878340 c.168C>T synonymous_variant 0.27 rifampicin
rpoA 3878346 c.162T>C synonymous_variant 0.28 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.23 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.23 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.24 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.25 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.28 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.26 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.25 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.24 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.22 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.18 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.18 rifampicin
rpoA 3878484 c.24C>A synonymous_variant 0.18 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.27 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.26 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.26 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.28 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.35 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.35 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.29 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.32 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.32 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.33 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.26 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.23 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.2 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.2 rifampicin
rpoA 3878909 c.-402A>G upstream_gene_variant 0.21 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.24 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.25 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.31 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.32 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.32 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.32 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.31 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.23 rifampicin
clpC1 4038596 c.2109A>G synonymous_variant 0.31 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.33 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.4 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.39 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.38 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.38 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.39 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.35 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.34 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.34 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038749 c.1956C>G synonymous_variant 0.36 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.33 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.33 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.48 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.48 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.45 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.38 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.24 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.24 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.2 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039480 c.1225C>A synonymous_variant 0.16 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTG frameshift_variant&missense_variant 0.16 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.23 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.29 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.27 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.23 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.22 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.26 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.22 pyrazinamide
glpK 4138681 p.Met359Val missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138695 p.Pro354Asp missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.29 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>G synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138796 c.960A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138802 c.954G>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139588 c.168G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139601 p.Arg52Gln missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139611 p.Ile49Val missense_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139615 c.141G>A synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139651 c.103_105delCACinsGG frameshift_variant&missense_variant 0.3 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4240780 c.918T>C synonymous_variant 0.26 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.26 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.26 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.33 ethambutol
embC 4240828 c.966G>C synonymous_variant 0.32 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.29 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.35 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.29 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.25 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.23 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.24 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4245137 c.1905T>C synonymous_variant 0.27 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.28 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.29 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.29 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.22 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.23 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.26 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.26 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.27 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.27 ethambutol Uncertain significance
embA 4245282 p.Ile684Val missense_variant 0.23 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.25 ethambutol
embB 4247371 c.858C>G synonymous_variant 0.21 ethambutol
embB 4247375 p.Leu288Val missense_variant 0.22 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.23 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.24 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.26 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.3 ethambutol
embB 4247407 c.894G>C synonymous_variant 0.3 ethambutol
embB 4247413 c.900C>T synonymous_variant 0.36 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.36 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.34 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.33 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.36 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.41 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.42 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.4 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.36 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.4 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.16 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.15 ethambutol Uncertain significance
embB 4247830 c.1317A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.19 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.18 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.17 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.18 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.19 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.2 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.19 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.2 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.17 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.17 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4248130 c.1617G>C synonymous_variant 0.16 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.16 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.16 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4249469 p.Leu986Met missense_variant 0.23 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.23 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.17 ethambutol
embB 4249568 p.Ser1019Thr missense_variant 0.19 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.21 ethambutol
aftB 4268144 c.693T>C synonymous_variant 0.19 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 0.17 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.17 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.16 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R