TB-Profiler result

Run: SRR1165506
Summary

Run ID: SRR1165506

Sample name:

Date: 2024-10-04T23:28:50.910235

Number of reads: 5859845

Percentage reads mapped: 81.03

Median coverage: 137.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.97
lineage4.1.2 Euro-American None 1.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.97
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.32 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.15 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 741 c.741T>C synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 750 c.750C>G synonymous_variant 0.15 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.14 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.14 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.17 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.17 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.17 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.22 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.2 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.2 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.2 isoniazid
dnaA 1164 c.1164A>T synonymous_variant 0.19 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.18 isoniazid
dnaA 1177 p.Ala393Ser missense_variant 0.19 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.22 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.22 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.22 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.22 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.18 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.18 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.19 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.18 isoniazid
gyrB 5827 c.588G>A synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 5848 c.609G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6115 c.876A>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 6123 p.Ala295Gly missense_variant 0.16 levofloxacin
moxifloxacin
gyrB 6127 c.888G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6133 c.894G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6136 c.897G>A synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrB 6148 c.909C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6169 c.930C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6190 c.951A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6209 c.970C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6214 c.975G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.18 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6299 c.1060C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6361 c.-941G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6362 c.-940T>C upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6379 c.-923C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6382 c.-920A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6388 c.-914T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6400 c.-902C>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.19 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7760 c.459C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7883 c.582G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7884 p.Arg195Gly missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7892 c.591G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 7919 p.Glu206Asp missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 7923 p.His208Tyr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7928 p.Asp209Glu missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8093 c.792C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8096 c.795T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8235 c.934_936delTTAinsCTG synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8348 c.1047C>A synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8363 c.1062C>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 p.Tyr364His missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8498 c.1197C>T synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8537 c.1236G>A synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8966 c.1665C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9233 c.1932C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9275 c.1974G>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9278 c.1977G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9281 c.1980C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
gyrA 9311 c.2010C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
fgd1 491526 c.744T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491532 c.750G>T synonymous_variant 0.2 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491542 c.760T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491547 c.765A>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491550 c.768T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491583 c.801G>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491591 p.Lys270Met missense_variant 0.83 pretomanid
delamanid Uncertain significance
clofazimine Not assoc w R
fgd1 491595 c.813C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491601 c.819T>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
mshA 575679 p.Asn111Ser missense_variant 0.97 isoniazid Not assoc w R
ethionamide Not assoc w R
Rv0565c 657269 p.Ser68Pro missense_variant 0.89 ethionamide Uncertain significance
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.19 ethionamide
Rv0565c 657639 c.-169C>G upstream_gene_variant 0.19 ethionamide
Rv0565c 657641 c.-171C>G upstream_gene_variant 0.2 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.2 ethionamide
hadA 731753 c.-177A>G upstream_gene_variant 0.14 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.16 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 0.15 isoniazid
hadA 731792 c.-138G>A upstream_gene_variant 0.15 isoniazid
hadA 731801 c.-129C>G upstream_gene_variant 0.14 isoniazid
hadA 732295 c.366G>C synonymous_variant 0.14 isoniazid
hadA 732304 c.375C>T synonymous_variant 0.14 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.14 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.15 isoniazid
hadA 732337 c.408G>A synonymous_variant 0.15 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.16 isoniazid
nusG 734499 c.246G>C synonymous_variant 0.14 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.19 rifampicin
rpoB 760115 c.309C>T synonymous_variant 0.88 rifampicin Not assoc w R
rpoB 760142 c.336C>G synonymous_variant 0.15 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.23 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.21 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.19 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.19 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.18 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.19 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.23 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.25 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.24 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.21 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.24 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.26 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.19 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.17 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.15 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.19 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.19 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.18 rifampicin
rpoB 760763 c.957C>T synonymous_variant 0.18 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.17 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.17 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.16 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.22 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.23 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.18 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.18 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.24 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.28 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.29 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.27 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.3 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.29 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.28 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.3 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.25 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>A synonymous_variant 0.18 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.17 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.18 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761297 c.1491C>T synonymous_variant 0.23 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761360 c.1554T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.16 rifampicin
rpoB 761374 p.Val523Glu missense_variant 0.14 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.15 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761791 p.Arg662His missense_variant 0.15 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.14 rifampicin
rpoB 761815 p.Ala670Asp missense_variant 0.14 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.16 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.16 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.15 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.15 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.15 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.15 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.15 rifampicin
rpoB 761924 c.2118G>A synonymous_variant 0.19 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.23 rifampicin
rpoB 762008 c.2202C>G synonymous_variant 0.24 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.22 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.14 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.14 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.16 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762443 c.-927G>T upstream_gene_variant 0.16 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762521 c.-849C>G upstream_gene_variant 0.14 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.14 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.14 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.17 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.34 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.3 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.3 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.31 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.28 rifampicin
rpoC 763202 c.-168A>C upstream_gene_variant 0.24 rifampicin
rpoC 763205 c.-165G>C upstream_gene_variant 0.24 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCC upstream_gene_variant 0.23 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.26 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.21 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.24 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.28 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.3 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTTG synonymous_variant 0.27 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.24 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.29 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.28 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.29 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.3 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.31 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.32 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.25 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.23 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.22 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.23 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.25 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.23 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.24 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.35 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.36 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.35 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.33 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.28 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.29 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.24 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.25 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.21 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.17 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.17 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.17 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.24 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.16 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.15 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.15 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 0.15 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.29 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764573 c.1204_1206delCTTinsTTG synonymous_variant 0.25 rifampicin
rpoC 764576 c.1207_1208delTCinsAG synonymous_variant 0.23 rifampicin
rpoC 764581 c.1212T>C synonymous_variant 0.23 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764714 c.1345C>T synonymous_variant 0.33 rifampicin
rpoC 764720 c.1351C>T synonymous_variant 0.31 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.28 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.28 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.28 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.28 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.27 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.26 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.25 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.15 rifampicin
rpoC 765085 c.1716T>C synonymous_variant 0.15 rifampicin
rpoC 765089 c.1720T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765103 c.1734G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 0.99 rifampicin Not assoc w R
rpoC 765349 c.1980T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765404 p.Leu679Val missense_variant 0.25 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.21 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.22 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.29 rifampicin
rpoC 765452 p.Ala695Ser missense_variant 0.28 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.28 rifampicin
rpoC 765499 c.2130C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.31 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.28 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.29 rifampicin
rpoC 765577 c.2208G>C synonymous_variant 0.25 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.25 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.25 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.28 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.27 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.25 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.24 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.29 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.3 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.31 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.36 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.35 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.26 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 766015 c.2646G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766021 c.2652G>C synonymous_variant 0.21 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.25 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.27 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.26 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.26 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.3 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.27 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.22 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.16 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766483 c.3114G>C synonymous_variant 0.15 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.15 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.16 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766528 c.3159T>G synonymous_variant 0.18 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.2 rifampicin
rpoC 766583 p.Gly1072Ser missense_variant 0.21 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.21 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.23 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.23 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.24 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.25 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.26 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.25 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.28 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.34 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.32 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766769 c.3400C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.3 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.25 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766894 c.3525T>C synonymous_variant 0.23 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.22 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.23 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.18 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.18 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.19 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.24 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.23 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.21 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.2 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 0.99 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 775937 c.2544G>C synonymous_variant 0.18 bedaquiline
clofazimine
mmpL5 775966 p.Ala839Ser missense_variant 0.15 bedaquiline
clofazimine
mmpL5 775975 c.2506T>C synonymous_variant 0.17 bedaquiline
clofazimine
mmpL5 775981 p.Leu834Met missense_variant 0.15 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781608 p.Ser17Gly missense_variant 0.19 streptomycin
rpsL 781631 c.72G>C synonymous_variant 0.25 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.27 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.29 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.28 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.29 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.29 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.27 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.27 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.28 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.27 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.28 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.31 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.31 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.32 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.33 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.33 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.37 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.36 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.34 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.35 streptomycin Uncertain significance
rplC 800516 c.-293G>T upstream_gene_variant 0.17 linezolid
rplC 800537 c.-272C>T upstream_gene_variant 0.22 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.22 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.26 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.29 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.28 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.25 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.26 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.24 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.23 linezolid
rplC 800690 c.-119C>T upstream_gene_variant 0.18 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.18 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.2 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.19 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.17 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.16 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.15 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.16 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.21 linezolid
rplC 800794 c.-15_-9delAGATTGGinsGAGTT upstream_gene_variant 0.2 linezolid
rplC 800814 c.6A>G synonymous_variant 0.24 linezolid
rplC 800817 c.9A>T synonymous_variant 0.26 linezolid
rplC 800844 c.36T>C synonymous_variant 0.22 linezolid
rplC 800865 c.57A>G synonymous_variant 0.15 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.14 linezolid
rplC 800889 c.81C>G synonymous_variant 0.15 linezolid
rplC 800907 c.99C>G synonymous_variant 0.15 linezolid
rplC 801312 c.504G>C synonymous_variant 0.14 linezolid
rplC 801339 c.531T>C synonymous_variant 0.14 linezolid
rplC 801341 p.Leu178His missense_variant 0.14 linezolid
rplC 801357 c.549T>C synonymous_variant 0.18 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.18 linezolid
rplC 801396 c.588T>C synonymous_variant 0.16 linezolid
rplC 801402 c.594T>C synonymous_variant 0.16 linezolid
rplC 801405 c.597T>C synonymous_variant 0.15 linezolid
fbiC 1303785 c.855G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304961 c.2031C>T synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1305311 p.Arg794Gln missense_variant 0.12 pretomanid
delamanid
clofazimine
atpE 1461132 p.Val30Ile missense_variant 0.18 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.2 bedaquiline
atpE 1461150 p.Ile36Val missense_variant 0.2 bedaquiline
atpE 1461159 p.Val39Ile missense_variant 0.25 bedaquiline Uncertain significance
atpE 1461185 c.141G>C synonymous_variant 0.3 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.28 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.28 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.26 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.25 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.24 bedaquiline
atpE 1461233 c.189A>G synonymous_variant 0.2 bedaquiline
atpE 1461254 c.210T>C synonymous_variant 0.14 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.36 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.32 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.24 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472030 n.185G>A non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.23 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472044 n.199G>C non_coding_transcript_exon_variant 0.29 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.27 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.35 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.33 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.31 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445delCinsTTT non_coding_transcript_exon_variant 0.28 kanamycin
capreomycin
streptomycin
amikacin
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474291 n.634_649delTTTCCTCTCCGGAGGAinsC non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475271 n.1614A>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475273 n.1616T>A non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.28 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476723 n.3066T>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476725 n.3068C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
inhA 1674321 c.120G>C synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674480 c.279T>C synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674486 c.285T>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674489 c.288G>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674507 c.306G>C synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674537 c.336C>G synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.24 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.25 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.22 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.18 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.17 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.16 isoniazid
ethionamide
rpsA 1833554 p.Thr5Ala missense_variant 0.21 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.25 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.24 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.25 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.22 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.31 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.37 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.37 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.36 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834097 p.Ser186Thr missense_variant 0.13 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834201 c.660C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.23 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.18 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.2 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.27 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.31 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834594 c.1053C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.18 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.18 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
bacA 2063642 p.Asp363Tyr missense_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
katG 2155632 c.480A>C synonymous_variant 0.17 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.19 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.21 isoniazid Uncertain significance
katG 2155747 p.Ala122Gly missense_variant 0.27 isoniazid
PPE35 2170173 c.437_439dupTGG conservative_inframe_insertion 1.0 pyrazinamide Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517947 c.-168C>T upstream_gene_variant 0.25 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.23 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.19 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.19 isoniazid
kasA 2518076 c.-39C>T upstream_gene_variant 1.0 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.13 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.16 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.19 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.18 isoniazid
kasA 2518222 c.108G>A synonymous_variant 0.16 isoniazid
kasA 2518223 c.109_111delTTGinsCTC synonymous_variant 0.16 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.18 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.16 isoniazid
ahpC 2726612 c.420C>G synonymous_variant 0.16 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.16 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.15 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.15 isoniazid Not assoc w R - Interim
Rv2477c 2782450 c.1593C>G synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782453 c.1590C>A synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782483 c.1560G>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.2 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.21 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.2 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.21 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783920 c.123G>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.27 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.27 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.23 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2784358 c.-316T>A upstream_gene_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2680 2996034 c.-71G>A upstream_gene_variant 0.18 capreomycin Uncertain significance
Rv2680 2996085 c.-20G>A upstream_gene_variant 0.39 capreomycin Uncertain significance
Rv2752c 3065687 p.Gly169Ser missense_variant 1.0 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065947 p.Gly82Ala missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065955 p.Leu79Phe missense_variant 0.14 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066024 c.168T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066050 p.Leu48Met missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066054 c.138T>G synonymous_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066066 c.126T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066075 c.117A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067682 c.264G>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073812 c.660C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073824 c.648A>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073827 c.645A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073839 c.633T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073872 p.Ile200Val missense_variant 0.26 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074010 c.462C>A synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.15 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074097 c.375C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.14 para-aminosalicylic_acid
thyA 3074155 p.Gly106Asp missense_variant 0.86 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625572 p.Thr348Ser missense_variant 0.15 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3625592 p.Ser341Asn missense_variant 0.16 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.15 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625627 c.-717C>T upstream_gene_variant 0.15 rifampicin
bedaquiline
lpqB 3625648 c.-738T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625735 c.879C>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.17 rifampicin Uncertain significance
bedaquiline
mtrB 3625762 c.852A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.16 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625840 c.-930A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625882 c.732G>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626795 c.-182C>T upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626798 c.-185T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627170 c.-557C>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627191 c.-578G>C upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3627197 c.-584T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
rpoA 3877494 p.Glu338Asp missense_variant 0.17 rifampicin Uncertain significance
rpoA 3877503 c.1005G>C synonymous_variant 0.18 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.19 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.23 rifampicin
rpoA 3877542 c.966C>T synonymous_variant 0.25 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.22 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.17 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.18 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.17 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.2 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.17 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.15 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.16 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878070 c.438T>C synonymous_variant 0.15 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.18 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.17 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.17 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.18 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.18 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.21 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.21 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.21 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.2 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.18 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.21 rifampicin
rpoA 3878364 c.144A>G synonymous_variant 0.18 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.19 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.2 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.22 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.23 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.24 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.25 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.24 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.21 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.2 rifampicin
clpC1 4038347 c.2358G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.17 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.24 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.19 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038452 c.2253G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038461 p.Ala748Asp missense_variant 0.2 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.26 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.24 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.17 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.15 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.15 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.14 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.17 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.26 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.28 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039127 c.1578G>A synonymous_variant 0.17 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039532 c.1173C>T synonymous_variant 0.14 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.14 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.22 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040459 c.246C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>A synonymous_variant 0.15 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
glpK 4139554 p.Ala68Ser missense_variant 0.13 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139575 p.Val61Ile missense_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139581 p.Asn59Asp missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139597 c.159C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139630 c.126C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139651 p.His35Gln missense_variant 0.15 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4240706 p.Val282Met missense_variant 0.14 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.14 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.19 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.2 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.21 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.19 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.19 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.16 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.15 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.99 ethambutol Not assoc w R
embA 4245077 c.1845G>C synonymous_variant 0.15 ethambutol
embA 4245083 c.1851A>C synonymous_variant 0.16 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.16 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.16 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.17 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.22 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.19 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.15 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.15 ethambutol
embB 4247440 c.927C>G synonymous_variant 0.15 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.15 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.15 ethambutol
embB 4248052 c.1539G>A synonymous_variant 0.14 ethambutol
embB 4248055 c.1542G>C synonymous_variant 0.14 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.18 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.21 ethambutol
embB 4248095 c.1582_1584delCTCinsTTG synonymous_variant 0.17 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.18 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.19 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.2 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.19 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.19 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248206 p.Ser565Gly missense_variant 0.2 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
aftB 4269201 c.-365A>G upstream_gene_variant 0.16 ethambutol
ubiA 4269209 p.Ser209Ala missense_variant 0.16 ethambutol
ubiA 4269220 p.Ala205Lys missense_variant 0.16 ethambutol
ubiA 4269222 c.612T>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
aftB 4269225 c.-389C>G upstream_gene_variant 0.16 ethambutol
aftB 4269231 c.-395C>G upstream_gene_variant 0.15 ethambutol
aftB 4269234 c.-398A>G upstream_gene_variant 0.15 ethambutol
ubiA 4269243 p.His197Gln missense_variant 0.15 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.99 kanamycin
capreomycin
amikacin