TB-Profiler result

Run: SRR5341396
Summary

Run ID: SRR5341396

Sample name:

Date: 2024-04-16T08:36:55.386398

Number of reads: 141397

Percentage reads mapped: 6.88

Median coverage: 2.0

Strain: lineage3;lineage4.9

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage3 East-African-Indian RD750 0.11
lineage4 Euro-American None 0.93
lineage4.9 Euro-American (H37Rv-like) None 0.93
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.888G>A Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 771 c.771A>G synonymous_variant 0.9 isoniazid
dnaA 793 c.793_795delGTAinsAC frameshift_variant&missense_variant 0.92 isoniazid Uncertain significance
dnaA 801 c.801G>T synonymous_variant 0.92 isoniazid
dnaA 804 c.804G>C synonymous_variant 0.92 isoniazid
dnaA 805 c.805_807delTTGinsCC frameshift_variant&missense_variant 0.92 isoniazid Uncertain significance
dnaA 822 c.822A>G synonymous_variant 0.85 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.83 isoniazid Not assoc w R - Interim
gyrA 6673 c.-629A>C upstream_gene_variant 0.92 levofloxacin
moxifloxacin
gyrA 6676 c.-626T>G upstream_gene_variant 0.86 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.83 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.83 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.83 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.83 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.82 levofloxacin
moxifloxacin
gyrB 6728 c.1489_1491delCTAinsTG frameshift_variant&stop_gained 0.82 levofloxacin Uncertain significance
moxifloxacin
gyrA 6739 c.-563C>T upstream_gene_variant 0.69 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.67 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.67 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6808 c.1569C>G synonymous_variant 0.69 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6824 c.1585C>T synonymous_variant 0.6 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.85 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7412 c.111C>G synonymous_variant 0.9 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.6 levofloxacin
moxifloxacin
gyrA 7499 c.198G>C synonymous_variant 0.69 levofloxacin
moxifloxacin
gyrA 7526 c.225G>A synonymous_variant 0.41 levofloxacin
moxifloxacin
gyrA 7526 c.225G>C synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.87 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7553 c.252C>T synonymous_variant 0.56 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.61 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7565 c.264C>T synonymous_variant 0.86 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7569 p.Ala90Ser missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 7574 c.273G>C synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7589 c.288G>C synonymous_variant 0.73 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7595 c.294C>T synonymous_variant 0.89 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>T synonymous_variant 0.87 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7637 c.336C>A synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8609 c.1308G>C synonymous_variant 0.55 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>T synonymous_variant 0.64 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8633 c.1332C>G synonymous_variant 0.58 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.54 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8645 c.1344C>G synonymous_variant 0.54 levofloxacin
moxifloxacin
gyrA 8649 p.Arg450Lys missense_variant 0.54 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.7 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>G synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.88 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.94 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8942 c.1641G>T synonymous_variant 0.92 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8945 c.1644G>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.92 levofloxacin
moxifloxacin
gyrA 8957 c.1656C>T synonymous_variant 0.8 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Lys missense_variant 0.73 levofloxacin
moxifloxacin
gyrA 8978 c.1677C>T synonymous_variant 0.7 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
ccsA 620397 c.507C>G synonymous_variant 0.73 capreomycin
amikacin
kanamycin
hadA 731747 c.-183T>C upstream_gene_variant 0.73 isoniazid
hadA 731756 c.-174C>T upstream_gene_variant 0.73 isoniazid
hadA 731760 c.-170_-169delGTinsAC upstream_gene_variant 0.73 isoniazid
hadA 731789 c.-141A>G upstream_gene_variant 1.0 isoniazid
hadA 731798 c.-132C>G upstream_gene_variant 0.8 isoniazid
nusG 734472 c.219T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
nusG 734497 c.244_246delGTGinsAC frameshift_variant&missense_variant 0.75 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.91 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.77 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 760608 c.802C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 760668 c.862_864delACGinsGC frameshift_variant&missense_variant 0.65 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 0.71 rifampicin
rpoB 760730 c.924T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761258 c.1452G>A synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 761333 c.1527G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 761555 c.1749G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762131 c.2325C>G synonymous_variant 0.7 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.73 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.73 rifampicin
rpoB 762158 c.2352G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoB 762275 c.2469C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 762323 c.2517C>A synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762404 c.2598T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.5 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.53 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.53 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 762894 c.3088C>T synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoB 763145 c.3339G>A synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoB 763157 c.3351G>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 763531 c.162G>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.92 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.9 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764491 c.1122G>T synonymous_variant 0.47 rifampicin
rpoC 764497 c.1128A>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.53 rifampicin
rpoC 764510 c.1141_1143delCTGinsTT frameshift_variant&synonymous_variant 0.41 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>A synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764605 c.1236G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764623 c.1254C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764692 c.1323C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.83 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.61 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>T synonymous_variant 0.38 rifampicin
rpoC 764878 c.1509C>G synonymous_variant 0.37 rifampicin
rpoC 764887 c.1518G>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 1.0 rifampicin
rpoC 764912 p.Met515Gln missense_variant 1.0 rifampicin Uncertain significance
rpoC 765403 c.2034G>C synonymous_variant 0.67 rifampicin
rpoC 765405 p.Leu679His missense_variant 0.62 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765449 c.2080_2082delGCCinsTG frameshift_variant&missense_variant 0.85 rifampicin
rpoC 765454 c.2085C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 765469 c.2100G>C synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>G synonymous_variant 1.0 rifampicin
rpoC 765480 p.Tyr704Phe missense_variant 1.0 rifampicin Uncertain significance
rpoC 765835 c.2466C>T synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 765841 c.2472G>T synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoC 765861 p.Phe831Tyr missense_variant 0.67 rifampicin Uncertain significance
rpoC 765875 p.Val836Ile missense_variant 0.85 rifampicin Uncertain significance
rpoC 765907 c.2538G>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 766570 c.3201T>C synonymous_variant 0.82 rifampicin
rpoC 766573 c.3204T>G synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoC 766837 c.3468G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 766858 c.3489C>T synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 766867 c.3498C>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoC 767107 c.3738C>T synonymous_variant 0.86 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.85 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767179 c.3810C>T synonymous_variant 0.85 rifampicin
rpoC 767180 p.Ala1271Ser missense_variant 1.0 rifampicin Uncertain significance
rpoC 767191 c.3822C>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>G synonymous_variant 0.76 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.72 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpsL 781595 c.36T>C synonymous_variant 0.8 streptomycin
rpsL 781608 p.Ser17Ala missense_variant 0.8 streptomycin
rpsL 781616 c.57C>G synonymous_variant 0.4 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.81 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.87 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.85 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.77 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.81 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.81 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.48 streptomycin Not assoc w R - Interim
rpsL 781859 c.300T>G synonymous_variant 0.4 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.87 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.87 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.48 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.89 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.85 streptomycin
rpsL 781901 c.342C>T synonymous_variant 0.57 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.95 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.95 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 1.0 streptomycin Uncertain significance
sigE 1364742 c.330A>G synonymous_variant 0.8 pyrazinamide
atpE 1461161 c.117C>G synonymous_variant 0.67 bedaquiline
atpE 1461164 c.120C>T synonymous_variant 0.67 bedaquiline
atpE 1461167 c.123G>T synonymous_variant 0.75 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.75 bedaquiline
atpE 1461179 c.135G>T synonymous_variant 0.75 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.77 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.77 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.85 bedaquiline
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472122 n.277G>A non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.25 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472128 n.283G>A non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472129 n.284G>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472164 n.319G>A non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472177 n.332C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472203 n.358G>A non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472210 n.365A>C non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472213 n.368G>C non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472215 n.370A>G non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472234 n.389T>C non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472236 n.391C>G non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.41 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472541 n.696T>G non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472596 n.751G>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472598 n.753A>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472614 n.769G>T non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.21 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.55 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.56 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472846 n.1001C>T non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472847 n.1002G>A non_coding_transcript_exon_variant 0.94 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472848 n.1003T>C non_coding_transcript_exon_variant 0.65 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472861 n.1016G>A non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.57 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.57 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.53 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.92 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.96 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.95 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473147 n.1302G>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.33 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473164 n.1319C>A non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473172 n.1327T>C non_coding_transcript_exon_variant 0.35 streptomycin Not assoc w R
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.35 streptomycin Not assoc w R
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473191 n.1346C>T non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473201 n.1356_1357delACinsT non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473206 n.1361G>A non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.92 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.96 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.28 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid
rrl 1473770 n.113T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473812 n.155G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1473831 n.174G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid
rrl 1473832 n.175C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1473839 n.182G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473887 n.230T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473888 n.231T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473924 n.267_268insT non_coding_transcript_exon_variant 0.83 capreomycin
linezolid
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524_525insT non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474184 n.527C>A non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474185 n.529delA non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474282 n.625G>A non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474413 n.756A>C non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1474640 n.983C>T non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1474743 n.1086T>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1475760 n.2105_2106delGC non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475858 n.2201T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.52 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.82 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.7 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.69 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.81 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.85 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833589 c.48A>C synonymous_variant 0.9 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.9 pyrazinamide
rpsA 1833625 c.84A>G synonymous_variant 0.8 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.73 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.75 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.75 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.73 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.73 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.73 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.73 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.7 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.77 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.83 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.88 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.8 pyrazinamide
rpsA 1833823 c.282G>A synonymous_variant 0.75 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.88 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.88 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.88 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.89 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.89 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.94 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.83 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.89 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 1.0 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.92 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.86 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.67 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.82 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.82 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.75 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.81 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.88 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.87 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.89 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.89 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.89 pyrazinamide
rpsA 1834033 c.492C>T synonymous_variant 0.76 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.7 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.7 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.73 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>T synonymous_variant 0.7 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.8 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.82 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.82 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.92 pyrazinamide
rpsA 1834357 c.816T>C synonymous_variant 0.71 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.5 pyrazinamide
rpsA 1834429 c.888C>T synonymous_variant 0.4 pyrazinamide
rpsA 1834438 c.897C>T synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
rpsA 1834606 c.1065C>T synonymous_variant 0.73 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.67 pyrazinamide
rpsA 1834619 c.1078T>C synonymous_variant 0.58 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.58 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.62 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.6 pyrazinamide
rpsA 1834645 c.1104C>T synonymous_variant 0.56 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.69 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.69 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.82 pyrazinamide
rpsA 1834720 c.1179C>G synonymous_variant 0.77 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.94 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.88 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.89 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.88 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.81 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.8 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.81 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.81 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.76 pyrazinamide
rpsA 1834813 c.1272G>T synonymous_variant 0.69 pyrazinamide
kasA 2517917 c.-198G>C upstream_gene_variant 0.72 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.92 isoniazid
kasA 2517953 c.-162C>T upstream_gene_variant 0.55 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.88 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.73 isoniazid
Rv2477c 2783344 c.699C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783347 c.696C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.92 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.79 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783371 c.672A>G synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.83 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
mtrB 3625774 c.840G>A synonymous_variant 0.73 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625783 c.-873C>T upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrA 3626756 c.594C>G synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.71 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626762 c.588G>C synonymous_variant 0.77 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626786 c.564A>G synonymous_variant 0.83 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.82 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626804 c.546A>G synonymous_variant 0.88 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626825 c.525T>A synonymous_variant 0.87 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626846 c.504G>A synonymous_variant 0.8 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627098 c.252A>C synonymous_variant 0.91 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>T upstream_gene_variant 0.73 bedaquiline
rifampicin
mtrB 3627110 c.-497G>C upstream_gene_variant 0.9 bedaquiline
rifampicin
rpoA 3877560 c.948C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsAC frameshift_variant&missense_variant 0.88 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3877614 c.894G>A synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoA 3877620 c.888G>A synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.9 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3877665 c.843C>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877797 c.711G>A synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>A synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3877866 c.642G>C synonymous_variant 0.32 rifampicin
rpoA 3877872 c.636C>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3877878 c.630G>C synonymous_variant 0.28 rifampicin
rpoA 3877887 c.621G>C synonymous_variant 0.36 rifampicin
rpoA 3877893 c.615C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.96 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.97 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.34 rifampicin
rpoA 3877929 c.577_579delATCinsGG frameshift_variant&missense_variant 0.65 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.95 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.94 rifampicin Uncertain significance
rpoA 3877974 c.534G>T synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoA 3877977 p.Lys177Asn missense_variant 0.65 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878130 c.378C>G synonymous_variant 0.6 rifampicin
rpoA 3878142 p.Gly122Asp missense_variant 0.56 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoA 3878193 c.315T>C synonymous_variant 0.88 rifampicin Not assoc w R - Interim
rpoA 3878196 p.Glu104Ala missense_variant 0.75 rifampicin Uncertain significance
rpoA 3878205 c.303T>C synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.9 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.92 rifampicin Not assoc w R - Interim
clpC1 4038563 c.2142C>T synonymous_variant 0.64 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.91 pyrazinamide
clpC1 4038911 c.1794G>C synonymous_variant 0.9 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.8 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.8 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.8 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.82 pyrazinamide Not assoc w R - Interim
clpC1 4039070 c.1635G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.93 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.93 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.93 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.73 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.94 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.95 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 1.0 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.78 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.94 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.95 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.94 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.71 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.67 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.73 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 1.0 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.7 pyrazinamide Not assoc w R - Interim
clpC1 4039360 p.Ser449Arg missense_variant 0.5 pyrazinamide
clpC1 4039361 c.1344C>G synonymous_variant 0.81 pyrazinamide
clpC1 4039382 c.1323C>G synonymous_variant 0.75 pyrazinamide
clpC1 4039391 c.1314T>C synonymous_variant 0.71 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.67 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.67 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.67 pyrazinamide Uncertain significance
clpC1 4039418 c.1287C>G synonymous_variant 0.53 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.79 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.82 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4039466 c.1239T>C synonymous_variant 0.83 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.83 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.85 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.85 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.92 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.92 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.68 pyrazinamide
clpC1 4039528 c.1177C>A synonymous_variant 0.62 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.77 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.64 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.75 pyrazinamide
clpC1 4039565 c.1140G>T synonymous_variant 0.58 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.7 pyrazinamide Uncertain significance
clpC1 4039586 c.1119G>C synonymous_variant 0.53 pyrazinamide
clpC1 4039601 c.1104G>A synonymous_variant 0.53 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.8 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.79 pyrazinamide
clpC1 4039619 c.1086G>A synonymous_variant 0.63 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.83 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.88 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.79 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.88 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.89 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.92 pyrazinamide
clpC1 4039733 c.972G>A synonymous_variant 0.82 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.56 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.88 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.86 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.86 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.84 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.85 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.91 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.57 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.95 pyrazinamide
clpC1 4039799 c.906C>T synonymous_variant 0.63 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.75 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.75 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.69 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.85 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.82 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.88 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.88 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.94 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.94 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.72 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.76 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.68 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.71 pyrazinamide Not assoc w R - Interim
clpC1 4040009 c.696C>G synonymous_variant 0.76 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.72 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.87 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.88 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.9 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.68 pyrazinamide Not assoc w R - Interim
clpC1 4040087 c.618G>C synonymous_variant 0.83 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.82 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.9 pyrazinamide Not assoc w R - Interim
clpC1 4040126 c.579C>T synonymous_variant 0.85 pyrazinamide Not assoc w R - Interim
clpC1 4040309 c.396C>T synonymous_variant 0.8 pyrazinamide
clpC1 4040333 c.372G>C synonymous_variant 0.75 pyrazinamide
clpC1 4040342 c.363C>A synonymous_variant 0.75 pyrazinamide
clpC1 4040348 c.357G>T synonymous_variant 0.82 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.82 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.8 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.8 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.73 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.73 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.64 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.73 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.58 pyrazinamide Not assoc w R - Interim
clpC1 4040546 c.159G>C synonymous_variant 0.91 pyrazinamide
clpC1 4040558 c.147G>C synonymous_variant 0.85 pyrazinamide
clpC1 4040561 c.144A>G synonymous_variant 0.93 pyrazinamide
clpC1 4040573 c.132T>C synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4040579 c.126A>G synonymous_variant 0.8 pyrazinamide
clpC1 4040582 c.123G>C synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4040585 c.120A>G synonymous_variant 0.75 pyrazinamide
clpC1 4040597 c.108C>T synonymous_variant 0.79 pyrazinamide
clpC1 4040600 c.103_105delTTAinsCG frameshift_variant&missense_variant 0.77 pyrazinamide
clpC1 4040603 c.102T>G synonymous_variant 0.77 pyrazinamide
clpC1 4040606 c.99T>C synonymous_variant 0.77 pyrazinamide
embC 4240789 c.927T>C synonymous_variant 1.0 ethambutol
embC 4240819 c.957A>C synonymous_variant 1.0 ethambutol
embC 4240826 c.964_966delGCGinsTA frameshift_variant&stop_gained 0.64 ethambutol
embC 4240831 c.969T>G synonymous_variant 1.0 ethambutol