TB-Profiler result

Run: ERR4809333
Summary

Run ID: ERR4809333

Sample name:

Date: 2024-03-26T16:03:14.937134

Number of reads: 567949

Percentage reads mapped: 26.74

Median coverage: 16.0

Strain: lineage2.2.2

Spoligotype:

Drug-resistance: Pre-XDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.2 East-Asian (Beijing) RD105;RD207 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Ile Assoc w R
p.Gln497Lys Assoc w R
pyrazinamide pncA p.Cys14Arg Assoc w R
streptomycin rrs n.514A>C Assoc w R
n.799C>T Uncertain significance Mutation from literature
gid p.Leu79Ser Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin gyrA p.Ala90Val Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ofloxacin
levofloxacin gyrA p.Ala90Val Assoc w R
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
gyrA 7570 p.Ala90Val missense_variant 1.0 moxifloxacin Assoc w R Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
levofloxacin Assoc w R
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin Assoc w R
rrs 1472359 n.514A>C non_coding_transcript_exon_variant 0.33 streptomycin Assoc w R
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.8 streptomycin Uncertain significance Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance Mutation from literature
amikacin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.82 kanamycin Assoc w R
capreomycin Assoc w R
amikacin Assoc w R
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
pncA 2289202 p.Cys14Arg missense_variant 1.0 pyrazinamide Assoc w R
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol Assoc w R
embB 4248002 p.Gln497Lys missense_variant 1.0 ethambutol Assoc w R
gid 4407967 p.Leu79Ser missense_variant 1.0 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
rpoB 760916 c.1110C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 760925 c.1119T>C synonymous_variant 0.52 rifampicin
rpoB 760927 p.Thr374Ser missense_variant 0.51 rifampicin
rpoB 760940 c.1134G>C synonymous_variant 0.55 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 760953 p.Ile383Val missense_variant 0.55 rifampicin
rpoB 760958 c.1152G>C synonymous_variant 0.56 rifampicin
rpoB 760959 p.Val385Thr missense_variant 0.56 rifampicin
rpoB 760965 p.Met387Leu missense_variant 0.59 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.67 rifampicin
rpoB 761003 c.1197C>G synonymous_variant 0.75 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.71 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 761064 c.1258_1260delGCGinsTC frameshift_variant&missense_variant 0.57 rifampicin
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.57 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.59 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 761138 c.1332C>G synonymous_variant 0.52 rifampicin
rpoB 761973 p.His723Tyr missense_variant 0.43 rifampicin
rpoB 761999 c.2193G>C synonymous_variant 0.43 rifampicin
rpoB 762000 c.2194_2195delTCinsAG synonymous_variant 0.43 rifampicin
rpoB 762003 c.2197_2199delAACinsCG frameshift_variant&missense_variant 0.41 rifampicin
rpoB 762014 c.2208C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 762015 c.2209_2211delGAAinsCG frameshift_variant&missense_variant 0.41 rifampicin
rpoB 762020 p.Glu738Asp missense_variant 0.46 rifampicin
rpoB 762026 c.2220G>C synonymous_variant 0.52 rifampicin
rpoB 762030 p.Thr742Ser missense_variant 0.53 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoB 762057 p.Ile751Val missense_variant 0.55 rifampicin Uncertain significance
rpoB 762062 c.2256T>C synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoB 762084 c.2278_2280delGCGinsCC frameshift_variant&missense_variant 0.68 rifampicin
rpoB 762110 c.2304G>C synonymous_variant 0.74 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.74 rifampicin Uncertain significance
rpoB 762119 c.2313C>G synonymous_variant 0.71 rifampicin
rpoB 762122 p.Asp772Glu missense_variant 0.71 rifampicin
rpoB 762128 c.2322G>C synonymous_variant 0.7 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.76 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.75 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762156 c.2350_2352delGTGinsAC frameshift_variant&missense_variant 0.76 rifampicin
rpoB 762176 c.2370T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762189 c.2383_2385delATCinsCG frameshift_variant&missense_variant 0.71 rifampicin
rpoB 762194 c.2388G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoB 762209 c.2403C>G synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762212 c.2406G>C synonymous_variant 0.65 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 762266 c.2460T>C synonymous_variant 0.43 rifampicin
rpoB 762275 c.2469C>G synonymous_variant 0.39 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762832 p.Ser1009Thr missense_variant 0.42 rifampicin Uncertain significance
rpoC 762842 c.-528G>C upstream_gene_variant 0.48 rifampicin
rpoB 762844 p.Phe1013Tyr missense_variant 0.48 rifampicin
rpoC 762848 c.-522G>C upstream_gene_variant 0.5 rifampicin
rpoB 762849 p.Tyr1015Asp missense_variant 0.53 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoB 762858 c.3052_3054delACGinsTC frameshift_variant&missense_variant 0.48 rifampicin
rpoB 762863 c.3057T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoB 762879 c.3073_3075delATGinsCC frameshift_variant&missense_variant 0.5 rifampicin
rpoC 762896 c.-474G>C upstream_gene_variant 0.58 rifampicin
rpoC 762921 c.-449_-448delTCinsAG upstream_gene_variant 0.61 rifampicin
rpoC 762926 c.-444C>G upstream_gene_variant 0.59 rifampicin
rpoC 762947 c.-423C>G upstream_gene_variant 0.54 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 763468 c.99G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.42 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.48 rifampicin Not assoc w R - Interim
rpoC 763501 p.Asp44Glu missense_variant 0.54 rifampicin Uncertain significance
rpoC 763517 p.Lys50Arg missense_variant 0.57 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.57 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.6 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.58 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.58 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763551 p.Tyr61Ser missense_variant 0.66 rifampicin
rpoC 763570 c.201G>T synonymous_variant 0.68 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763585 c.216C>G synonymous_variant 0.67 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763625 p.Lys86Gly missense_variant 0.68 rifampicin
rpoC 763660 c.291T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>C synonymous_variant 0.57 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.52 rifampicin
rpoC 763708 c.339G>T synonymous_variant 0.54 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.5 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.57 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.54 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.5 rifampicin
rpoC 763765 c.396T>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763772 p.Val135Met missense_variant 0.38 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.52 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.56 rifampicin Not assoc w R - Interim
rpoC 764371 c.1002G>T synonymous_variant 0.58 rifampicin
rpoC 764377 c.1008C>G synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018_1020delTTGinsCC frameshift_variant&missense_variant 0.61 rifampicin
rpoC 764398 c.1029G>C synonymous_variant 0.61 rifampicin
rpoC 764405 c.1036A>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>C synonymous_variant 0.61 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.61 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCA frameshift_variant&missense_variant 0.61 rifampicin
rpoC 764441 p.Ile358Leu missense_variant 0.56 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.61 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.63 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.68 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.68 rifampicin
rpoC 764507 p.Ala380Asn missense_variant 0.68 rifampicin
rpoC 764512 c.1143G>C synonymous_variant 0.68 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.68 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.68 rifampicin
rpoC 764527 c.1158C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764533 c.1164C>T synonymous_variant 0.67 rifampicin
rpoC 764536 c.1167G>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 764537 c.1168_1170delCCCinsGG frameshift_variant&missense_variant 0.65 rifampicin
rpoC 764548 c.1179G>C synonymous_variant 0.68 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.8 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.8 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.8 rifampicin
rpoC 764605 c.1236G>C synonymous_variant 0.81 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 764620 c.1251G>C synonymous_variant 0.8 rifampicin
rpoC 764632 c.1263T>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoC 764662 c.1293G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 764677 c.1308C>G synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764705 p.Leu446Ala missense_variant 0.82 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 764722 c.1353G>C synonymous_variant 0.8 rifampicin
rpoC 764731 c.1362G>C synonymous_variant 0.77 rifampicin
rpoC 764737 c.1368G>C synonymous_variant 0.75 rifampicin
rpoC 764749 c.1380G>C synonymous_variant 0.75 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764759 p.Asn464Asp missense_variant 0.75 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoC 764767 c.1398G>C synonymous_variant 0.73 rifampicin
rpoC 764780 c.1411_1413delAGCinsTCG synonymous_variant 0.69 rifampicin
rpoC 764797 c.1428G>C synonymous_variant 0.69 rifampicin
rpoC 764803 c.1434C>T synonymous_variant 0.66 rifampicin Not assoc w R - Interim
rpoC 764810 p.Pro481Ser missense_variant 0.58 rifampicin Uncertain significance
rpoC 764813 p.Gln482Val missense_variant 0.56 rifampicin
rpoC 764817 p.Val483Gly missense_variant 0.43 rifampicin Uncertain significance
rpoC 764827 c.1458G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764843 p.Ala492Thr missense_variant 0.41 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764863 c.1494G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.4 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.62 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472286 n.441C>G non_coding_transcript_exon_variant 0.72 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472289 n.444T>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472290 n.445C>G non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472293 n.448C>A non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472297 n.453_465delGTCCGGGTTCTCT non_coding_transcript_exon_variant 0.71 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472313 n.468delGinsAA non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472315 n.470T>G non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472324 n.479G>C non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472325 n.480G>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.7 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472582 n.737G>A non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472583 n.738T>C non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.71 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.79 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.78 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472673 n.828T>A non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472674 n.829T>C non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.74 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.76 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472685 n.840G>A non_coding_transcript_exon_variant 0.76 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.77 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.77 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.75 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.54 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.83 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.87 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.86 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472991 n.1146G>A non_coding_transcript_exon_variant 0.86 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.91 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.89 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.85 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473127 n.1282G>A non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.87 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.9 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.89 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473292 n.1447_1449delGGAinsTGGG non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473292 n.1446_1447insT non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473292 n.1447_1449delGGAinsTGGG non_coding_transcript_exon_variant 0.46 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473292 n.1446_1447insT non_coding_transcript_exon_variant 0.42 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.88 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.85 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.84 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474153 n.496C>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474166 n.509G>T non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1474179 n.522C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474183 n.526T>C non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474252 n.595T>A non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474253 n.596A>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>T non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474660 n.1003G>A non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1474663 n.1006C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474664 n.1007G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474690 n.1033C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474709 n.1053_1056delTGGT non_coding_transcript_exon_variant 0.77 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060_1061insGTGAG non_coding_transcript_exon_variant 0.76 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.88 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474790 n.1133C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>C non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474869 n.1212G>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474938 n.1281G>A non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475655 n.1998T>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101A>G non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.66 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475991 n.2334T>A non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1475996 n.2339T>G non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.63 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.7 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.71 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476227 n.2570C>T non_coding_transcript_exon_variant 0.84 capreomycin
linezolid Uncertain significance
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.83 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476279 n.2622G>A non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476287 n.2631_2639delTCCGGCACC non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1476301 n.2644_2645insCGGTGGCTT non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1476309 n.2652G>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476422 n.2765C>G non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.88 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476431 n.2774G>C non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.72 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833838 c.297G>A synonymous_variant 0.4 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.44 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.41 pyrazinamide
rpsA 1833859 c.318C>T synonymous_variant 0.44 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.43 pyrazinamide
rpsA 1833893 p.Ala118Lys missense_variant 0.43 pyrazinamide
rpsA 1833896 p.Leu119Ile missense_variant 0.41 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.41 pyrazinamide
rpsA 1833905 p.Lys122Glu missense_variant 0.41 pyrazinamide
rpsA 1833912 p.Glu124Gly missense_variant 0.42 pyrazinamide
rpsA 1833915 p.Ala125Val missense_variant 0.42 pyrazinamide Uncertain significance
rpsA 1833921 p.Lys127Thr missense_variant 0.42 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.5 pyrazinamide
rpsA 1833955 c.414G>C synonymous_variant 0.63 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.61 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.6 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.6 pyrazinamide
rpsA 1833985 c.444G>C synonymous_variant 0.62 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.62 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.63 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834024 c.483G>C synonymous_variant 0.62 pyrazinamide
rpsA 1834034 c.493_495delATCinsGG frameshift_variant&missense_variant 0.59 pyrazinamide Uncertain significance
rpsA 1834069 c.528G>C synonymous_variant 0.58 pyrazinamide
rpsA 1834093 c.552G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834105 c.564C>T synonymous_variant 0.37 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.38 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834219 c.678C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834228 c.687C>T synonymous_variant 0.35 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834243 c.702G>C synonymous_variant 0.44 pyrazinamide
rpsA 1834246 c.705G>C synonymous_variant 0.48 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.48 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.54 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.59 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.72 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.73 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.72 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.74 pyrazinamide
rpsA 1834327 c.786G>C synonymous_variant 0.78 pyrazinamide
rpsA 1834330 c.789C>G synonymous_variant 0.77 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
rpsA 1834354 c.813G>T synonymous_variant 0.77 pyrazinamide
rpsA 1834357 c.816T>C synonymous_variant 0.77 pyrazinamide
rpsA 1834360 c.819G>C synonymous_variant 0.78 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.78 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.81 pyrazinamide Not assoc w R - Interim
rpsA 1834378 c.837T>G synonymous_variant 0.84 pyrazinamide
rpsA 1834384 c.843A>G synonymous_variant 0.84 pyrazinamide
rpsA 1834395 p.Arg285Gln missense_variant 0.85 pyrazinamide
rpsA 1834408 c.867C>G synonymous_variant 0.82 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.81 pyrazinamide
rpsA 1834423 c.882G>T synonymous_variant 0.76 pyrazinamide
rpsA 1834427 p.Ile296Val missense_variant 0.75 pyrazinamide Uncertain significance
rpsA 1834451 c.910_912delTTGinsCC frameshift_variant&missense_variant 0.73 pyrazinamide Uncertain significance
rpsA 1834456 c.915T>C synonymous_variant 0.7 pyrazinamide
rpsA 1834459 c.918G>C synonymous_variant 0.7 pyrazinamide
rpsA 1834468 c.927A>C synonymous_variant 0.68 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.65 pyrazinamide
rpsA 1834486 p.Glu315Asp missense_variant 0.62 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.61 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.59 pyrazinamide
rpsA 1834504 c.963G>C synonymous_variant 0.61 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2221939 p.Arg409Gln missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
rpoA 3877863 c.645G>C synonymous_variant 0.3 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.3 rifampicin
rpoA 3877875 c.633T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877878 c.630G>C synonymous_variant 0.34 rifampicin
rpoA 3877881 c.627G>C synonymous_variant 0.4 rifampicin
rpoA 3877893 c.615C>G synonymous_variant 0.42 rifampicin
rpoA 3877900 c.607_608delAGinsTC synonymous_variant 0.47 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoA 3877914 c.594C>G synonymous_variant 0.5 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoA 3877926 c.580_582delCTGinsGC frameshift_variant&missense_variant 0.52 rifampicin
rpoA 3877931 p.Ile193Val missense_variant 0.52 rifampicin Uncertain significance
rpoA 3877962 c.546G>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoA 3877965 c.543C>T synonymous_variant 0.46 rifampicin
rpoA 3877968 c.540C>G synonymous_variant 0.46 rifampicin
rpoA 3877971 p.Asp179Glu missense_variant 0.46 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.46 rifampicin
rpoA 3877989 p.Lys173Ala missense_variant 0.33 rifampicin
rpoA 3877995 c.513G>C synonymous_variant 0.35 rifampicin
rpoA 3878001 c.507A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
clpC1 4038767 c.1938G>C synonymous_variant 0.56 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.58 pyrazinamide
clpC1 4038794 c.1909_1911delAGCinsTCG synonymous_variant 0.65 pyrazinamide
clpC1 4038801 p.Tyr635Phe missense_variant 0.61 pyrazinamide
clpC1 4038810 p.Gln632Pro missense_variant 0.61 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.65 pyrazinamide
clpC1 4038826 p.Ile627Val missense_variant 0.62 pyrazinamide
clpC1 4038836 c.1869G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038842 c.1863G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.45 pyrazinamide
clpC1 4038851 c.1854G>C synonymous_variant 0.42 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4038869 c.1836G>A synonymous_variant 0.39 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039499 c.1206G>C synonymous_variant 0.39 pyrazinamide
clpC1 4039520 c.1185G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039523 c.1182C>T synonymous_variant 0.44 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.44 pyrazinamide
clpC1 4039537 p.Ile390Val missense_variant 0.43 pyrazinamide
clpC1 4039552 p.Leu385Met missense_variant 0.44 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039557 p.Ala383Val missense_variant 0.43 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039568 p.Met379Ile missense_variant 0.45 pyrazinamide Uncertain significance
clpC1 4039576 p.Ala377Pro missense_variant 0.46 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4039588 p.Ser373Thr missense_variant 0.5 pyrazinamide
clpC1 4039593 p.Arg371Lys missense_variant 0.47 pyrazinamide
clpC1 4039601 c.1104G>C synonymous_variant 0.49 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.45 pyrazinamide
clpC1 4039616 c.1089G>T synonymous_variant 0.44 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.43 pyrazinamide
clpC1 4039631 p.Ile358Met missense_variant 0.37 pyrazinamide
clpC1 4039838 c.865_867delCTGinsAC frameshift_variant&missense_variant 0.22 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039853 c.852G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039871 c.834C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039874 p.Asn277Lys missense_variant 0.33 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.39 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.55 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039940 c.765G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.5 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.5 pyrazinamide
clpC1 4039949 c.756G>C synonymous_variant 0.47 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.49 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.52 pyrazinamide
clpC1 4039984 p.Thr241Pro missense_variant 0.53 pyrazinamide
clpC1 4039988 c.717C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039994 c.709_711delGAGinsAC frameshift_variant&missense_variant 0.44 pyrazinamide
clpC1 4039997 p.Gly236Glu missense_variant 0.42 pyrazinamide
clpC1 4040002 p.His235Asp missense_variant 0.43 pyrazinamide
clpC1 4040003 c.702G>C synonymous_variant 0.43 pyrazinamide
clpC1 4040010 p.Ala232Asp missense_variant 0.42 pyrazinamide Uncertain significance
clpC1 4040015 c.690G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040018 c.687G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.42 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.48 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.48 pyrazinamide
clpC1 4040036 c.667_669delACCinsTT frameshift_variant&missense_variant 0.48 pyrazinamide
clpC1 4040063 c.642G>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
clpC1 4040066 c.639G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.42 pyrazinamide
clpC1 4040090 c.615T>G synonymous_variant 0.44 pyrazinamide
clpC1 4040976 c.-272T>G upstream_gene_variant 1.0 pyrazinamide
glpK 4139947 c.-192C>A upstream_gene_variant 1.0 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338218 c.146_303del frameshift_variant 1.0 capreomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338794 c.-273A>G upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R