TB-Profiler result

Run: ERR4817692
Summary

Run ID: ERR4817692

Sample name:

Date: 2024-10-04T12:58:41.847525

Number of reads: 2835646

Percentage reads mapped: 68.34

Median coverage: 64.0

Strain: lineage1.1.2;lineage4

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage1.1.2 Indo-Oceanic RD239 0.81
lineage1.1 Indo-Oceanic RD239 0.85
lineage4 Euro-American None 0.12
lineage1 Indo-Oceanic RD239 0.77
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ile335Thr Mutation from literature
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2155108 p.Ile335Thr missense_variant 0.24 isoniazid Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.23 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 534 c.534T>G synonymous_variant 0.17 isoniazid
dnaA 540 c.540C>G synonymous_variant 0.18 isoniazid
dnaA 543 c.543C>G synonymous_variant 0.18 isoniazid
dnaA 549 c.549C>T synonymous_variant 0.18 isoniazid
dnaA 571 c.571T>C synonymous_variant 0.19 isoniazid
dnaA 576 c.576G>C synonymous_variant 0.19 isoniazid
dnaA 582 c.582A>C synonymous_variant 0.2 isoniazid Not assoc w R - Interim
dnaA 591 c.591C>G synonymous_variant 0.2 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.17 isoniazid
dnaA 750 c.750C>G synonymous_variant 0.17 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.19 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.18 isoniazid
dnaA 795 c.795A>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
dnaA 805 c.805T>C synonymous_variant 0.18 isoniazid
dnaA 813 c.813C>T synonymous_variant 0.18 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.17 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.16 isoniazid
dnaA 876 c.876C>G synonymous_variant 0.19 isoniazid
dnaA 877 c.877T>C synonymous_variant 0.19 isoniazid
dnaA 885 c.885T>C synonymous_variant 0.19 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.2 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.18 isoniazid
dnaA 921 c.921A>G synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 1047 c.1047A>G synonymous_variant 0.21 isoniazid
dnaA 1068 c.1068T>C synonymous_variant 0.2 isoniazid
dnaA 1092 c.1092T>C synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.23 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.22 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.26 isoniazid
dnaA 1125 c.1125G>C synonymous_variant 0.25 isoniazid
dnaA 1152 c.1152A>G synonymous_variant 0.22 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.22 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.23 isoniazid
dnaA 1164 c.1164A>C synonymous_variant 0.21 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.22 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.22 isoniazid
dnaA 1177 p.Ala393Ser missense_variant 0.18 isoniazid
dnaA 1191 c.1191T>C synonymous_variant 0.24 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.2 isoniazid
dnaA 1204 c.1204C>T synonymous_variant 0.26 isoniazid
dnaA 1220 p.Asn407Ser missense_variant 0.23 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.21 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.24 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.28 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.24 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.18 isoniazid
dnaA 1290 c.1290G>A synonymous_variant 0.18 isoniazid
dnaA 1407 c.1407T>C synonymous_variant 0.18 isoniazid
dnaA 1416 c.1416C>G synonymous_variant 0.2 isoniazid
gyrB 5788 c.549G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 5806 c.567C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 5809 c.570C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 5824 c.585A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 5827 c.588G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 5863 c.624G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 5873 c.634A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6112 p.Met291Ile missense_variant 0.77 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6124 c.885C>T synonymous_variant 0.76 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6280 c.1041T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6319 c.1080G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6670 c.-632G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6673 c.-629A>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 6700 c.-602T>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.25 levofloxacin
moxifloxacin
gyrA 6730 c.-572A>G upstream_gene_variant 0.29 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.33 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.23 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6844 c.-458T>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 6853 c.-449A>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
gyrB 6856 c.1617T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6878 c.1639T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6881 c.1642T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6904 c.-398C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 0.98 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7457 c.156T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7607 c.306C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7631 c.330G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7658 c.357A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7676 c.375G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7683 c.382A>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7727 c.426G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7859 c.558A>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 7862 c.561C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7865 c.564T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7883 c.582G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 7884 p.Arg195Gly missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7892 c.591G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 7898 p.Asp199Glu missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8090 c.789C>A synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8129 c.828T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8237 c.936A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8435 c.1134C>G synonymous_variant 0.63 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8438 c.1137C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8452 p.Ala384Val missense_variant 0.69 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8486 c.1185T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8489 c.1188A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8498 c.1197C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8504 c.1203G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8561 c.1260A>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8603 c.1302A>G synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8624 c.1323G>C synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8801 c.1500G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8810 c.1509A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8829 c.1528T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8852 c.1551T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.27 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.89 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9182 c.1881T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9227 c.1926C>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9230 c.1929T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9242 c.1941A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9323 c.2022C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9666 p.Arg789Gly missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9674 c.2373T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
Rv0010c 13298 p.Ile87Met missense_variant 0.91 isoniazid Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 0.73 isoniazid Not assoc w R
fgd1 490803 c.21T>A synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 490812 c.30A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 490815 c.33G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 490827 c.45C>T synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 490851 c.69A>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490887 c.105G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 490902 c.120T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490905 c.123T>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 490911 c.129T>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 490917 c.135C>A synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 490921 p.Gln47Glu missense_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491181 c.399T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491191 p.Gly137Arg missense_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491196 c.414A>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491202 c.420G>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491203 p.Gln141Glu missense_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491212 p.Ser144Arg missense_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 491217 c.435T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491232 c.450T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fgd1 491241 p.Asp153Glu missense_variant 0.26 pretomanid
delamanid
clofazimine
fgd1 491244 c.462T>C synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491259 c.477T>C synonymous_variant 0.33 pretomanid
delamanid
clofazimine
fgd1 491286 c.504G>C synonymous_variant 0.38 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 491295 c.513C>G synonymous_variant 0.37 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.37 pretomanid
delamanid
clofazimine
fgd1 491319 c.537G>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 491331 c.549G>A synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491349 c.567T>C synonymous_variant 0.22 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491472 c.690A>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491502 c.720G>A synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491508 c.726A>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491509 c.727T>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fgd1 491512 p.Asn244Glu missense_variant 0.29 pretomanid
delamanid
clofazimine
fgd1 491526 c.744T>C synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fgd1 491542 c.760T>C synonymous_variant 0.38 pretomanid
delamanid
clofazimine
fgd1 491547 c.765A>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fgd1 491550 c.768T>C synonymous_variant 0.37 pretomanid
delamanid
clofazimine
fgd1 491583 c.801G>A synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fgd1 491601 c.819T>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fgd1 491610 c.828A>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 491742 c.960T>C synonymous_variant 0.86 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 574655 c.-693C>G upstream_gene_variant 0.19 isoniazid
ethionamide
mshA 575376 p.Ser10Leu missense_variant 0.89 isoniazid Uncertain significance
ethionamide Uncertain significance
mshA 575659 c.312A>G synonymous_variant 0.18 isoniazid
ethionamide
mshA 575665 c.318G>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575669 p.Leu108Val missense_variant 0.2 isoniazid
ethionamide
mshA 575689 c.342G>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575695 c.348C>G synonymous_variant 0.25 isoniazid Not assoc w R - Interim
ethionamide
mshA 575704 c.357T>C synonymous_variant 0.22 isoniazid
ethionamide
mshA 575705 c.358T>C synonymous_variant 0.25 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.26 isoniazid
ethionamide
mshA 575719 c.372C>T synonymous_variant 0.27 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.3 isoniazid
ethionamide
mshA 575737 c.390T>C synonymous_variant 0.3 isoniazid
ethionamide
mshA 575746 c.399C>G synonymous_variant 0.31 isoniazid
ethionamide
mshA 575767 c.420G>A synonymous_variant 0.23 isoniazid
ethionamide
mshA 575771 p.Val142Ser missense_variant 0.22 isoniazid
ethionamide
mshA 575779 c.432A>G synonymous_variant 0.29 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.36 isoniazid
ethionamide
mshA 575824 c.477T>G synonymous_variant 0.35 isoniazid
ethionamide
mshA 575864 c.517T>C synonymous_variant 0.24 isoniazid
ethionamide
mshA 575878 c.531A>G synonymous_variant 0.17 isoniazid
ethionamide
mshA 575884 c.537G>C synonymous_variant 0.25 isoniazid
ethionamide
ccsA 619535 c.-356C>G upstream_gene_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 619591 c.-300G>C upstream_gene_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 619634 c.-257T>A upstream_gene_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620367 c.477T>C synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620373 c.483C>G synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620385 c.495G>C synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>G synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.22 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620433 c.543C>G synonymous_variant 0.19 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620439 c.549T>C synonymous_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620445 c.555A>G synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620622 c.732G>C synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620646 c.756G>A synonymous_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620661 c.771C>G synonymous_variant 0.21 kanamycin
capreomycin
amikacin
Rv0565c 657219 p.Ala84Val missense_variant 0.25 ethionamide
Rv0565c 657222 c.249C>G synonymous_variant 0.24 ethionamide
Rv0565c 657231 p.Ile80Val missense_variant 0.24 ethionamide
Rv0565c 657237 c.234A>G synonymous_variant 0.26 ethionamide
Rv0565c 657242 p.Glu77Lys missense_variant 0.27 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.29 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.27 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.26 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.27 ethionamide
Rv0565c 657291 c.180C>G synonymous_variant 0.27 ethionamide
Rv0565c 657300 c.171C>T synonymous_variant 0.23 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.17 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.18 ethionamide
Rv0565c 657327 c.144C>G synonymous_variant 0.18 ethionamide
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.89 ethionamide
Rv0565c 657592 c.-122A>C upstream_gene_variant 0.16 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.28 ethionamide
hadA 732321 p.Glu131Ala missense_variant 0.2 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.26 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.3 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.24 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.32 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.2 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.31 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.32 isoniazid
nusG 734116 c.-138T>C upstream_gene_variant 0.74 rifampicin Not assoc w R
nusG 734120 c.-134T>C upstream_gene_variant 0.19 rifampicin Uncertain significance
nusG 734129 c.-125G>C upstream_gene_variant 0.2 rifampicin
nusG 734132 c.-122G>C upstream_gene_variant 0.21 rifampicin
nusG 734135 c.-119G>C upstream_gene_variant 0.21 rifampicin
nusG 734144 c.-110G>C upstream_gene_variant 0.19 rifampicin
nusG 734147 c.-107T>C upstream_gene_variant 0.18 rifampicin
nusG 734407 p.Val52Ile missense_variant 0.17 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.22 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.25 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.25 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.24 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.28 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.19 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.22 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734625 c.372T>C synonymous_variant 0.16 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.17 rifampicin
nusG 734754 c.501G>C synonymous_variant 0.23 rifampicin
nusG 734757 c.504T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734778 c.525G>C synonymous_variant 0.19 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.2 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.2 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.19 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.2 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.18 rifampicin
rpoB 760130 p.Asp108Glu missense_variant 0.19 rifampicin Uncertain significance
rpoB 760181 c.375T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.27 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.21 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.26 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.26 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.19 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.23 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.26 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.3 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.17 rifampicin Uncertain significance
rpoB 760563 p.Arg253Met missense_variant 0.18 rifampicin Uncertain significance
rpoB 760611 c.805T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.3 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.22 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.2 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760886 c.1080A>G synonymous_variant 0.25 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.2 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.27 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.24 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.27 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.28 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>A synonymous_variant 0.17 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.2 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.23 rifampicin
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.26 rifampicin
rpoB 761150 c.1344A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.24 rifampicin
rpoB 761171 c.1365C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761183 c.1377T>G synonymous_variant 0.25 rifampicin
rpoB 761189 c.1383T>G synonymous_variant 0.28 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.24 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761537 c.1731C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.23 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761948 c.2142G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761969 c.2163G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>G synonymous_variant 0.18 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.23 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.18 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.16 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.24 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.17 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.17 rifampicin Uncertain significance
rpoB 762929 c.3123G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.35 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.61 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.21 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.2 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.21 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763205 c.-165G>C upstream_gene_variant 0.21 rifampicin
rpoC 763206 c.-164_-162delAGTinsTCC upstream_gene_variant 0.21 rifampicin
rpoB 763214 c.3408T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763226 c.-144A>G upstream_gene_variant 0.21 rifampicin
rpoB 763238 c.3432T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>G synonymous_variant 0.21 rifampicin
rpoC 763411 c.42T>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.22 rifampicin
rpoC 763441 c.72C>G synonymous_variant 0.22 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 763603 c.234C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.3 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTTG synonymous_variant 0.17 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.21 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.2 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.2 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.27 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.17 rifampicin
rpoC 763780 c.411C>G synonymous_variant 0.2 rifampicin
rpoC 763783 c.414G>C synonymous_variant 0.2 rifampicin
rpoC 763801 c.432C>G synonymous_variant 0.22 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763819 c.450G>C synonymous_variant 0.2 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.18 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.24 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.25 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.21 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.22 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.22 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.67 rifampicin Not assoc w R
rpoC 763886 p.Arg173Ser missense_variant 0.67 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.22 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.26 rifampicin
rpoC 763919 c.550C>T synonymous_variant 0.18 rifampicin
rpoC 763933 c.564C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.22 rifampicin
rpoC 763978 c.609C>G synonymous_variant 0.23 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.31 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.21 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.33 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.31 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.34 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.33 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.37 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.31 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.22 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.31 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.29 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.26 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.22 rifampicin
rpoC 764320 c.951C>G synonymous_variant 0.19 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764381 c.1012_1013delTCinsAG synonymous_variant 0.2 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.34 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.36 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 0.29 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.31 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764581 c.1212T>C synonymous_variant 0.23 rifampicin
rpoC 764626 c.1257C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764714 c.1345C>T synonymous_variant 0.27 rifampicin
rpoC 764720 c.1351C>T synonymous_variant 0.22 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.21 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.19 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.29 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.3 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765022 c.1653G>C synonymous_variant 0.21 rifampicin
rpoC 765034 c.1665T>C synonymous_variant 0.32 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765047 c.1678T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765073 c.1704G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.23 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 0.16 rifampicin Not assoc w R
rpoC 765171 p.Pro601Leu missense_variant 0.77 rifampicin Not assoc w R
rpoC 765298 c.1929G>C synonymous_variant 0.31 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.32 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.29 rifampicin Uncertain significance
rpoC 765346 c.1977C>G synonymous_variant 0.19 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.34 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.32 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.32 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.18 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.21 rifampicin
rpoC 765452 p.Ala695Ser missense_variant 0.22 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765517 c.2148C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.35 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.32 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.33 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.26 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.27 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.38 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.3 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.36 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.34 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.34 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.28 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.29 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.33 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.32 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765970 c.2601C>T synonymous_variant 0.18 rifampicin
rpoC 765982 c.2613C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.16 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.25 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.29 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.27 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.3 rifampicin
rpoC 766069 c.2700G>A synonymous_variant 0.23 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.29 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.33 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.24 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.23 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.2 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766363 c.2994G>C synonymous_variant 0.18 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.17 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.17 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.19 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.25 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.32 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.28 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.28 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.28 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.25 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.28 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.23 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.23 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.28 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.25 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.31 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.3 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 766769 c.3400C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.36 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.4 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.39 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.27 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.28 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.27 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767014 c.3645G>C synonymous_variant 0.2 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.29 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.26 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.21 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.23 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.22 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.3 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.21 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767263 c.3894T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767264 p.Ala1299Gln missense_variant 0.19 rifampicin
rpoC 767275 c.3906T>C synonymous_variant 0.18 rifampicin
rpoC 767278 c.3909T>C synonymous_variant 0.18 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 0.93 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 0.98 streptomycin Not assoc w R
rpsL 781421 c.-139C>A upstream_gene_variant 0.17 streptomycin Uncertain significance
rpsL 781631 c.72G>C synonymous_variant 0.21 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.27 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.31 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.26 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.34 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.31 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.3 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.22 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.28 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.26 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.23 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.32 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.33 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.29 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.39 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.4 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.42 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.42 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.38 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.4 streptomycin Uncertain significance
rplC 800357 c.-452C>A upstream_gene_variant 0.85 linezolid Not assoc w R
rplC 800537 c.-272C>T upstream_gene_variant 0.17 linezolid
rplC 800540 c.-269T>C upstream_gene_variant 0.19 linezolid
rplC 800546 c.-263T>C upstream_gene_variant 0.21 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.22 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.2 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.17 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.19 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.19 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.19 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.2 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.2 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.19 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.18 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.17 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.2 linezolid
rplC 800814 c.6A>G synonymous_variant 0.25 linezolid
rplC 800817 c.9A>T synonymous_variant 0.27 linezolid
rplC 800844 c.36T>C synonymous_variant 0.28 linezolid
rplC 800865 c.57A>G synonymous_variant 0.23 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.22 linezolid
rplC 800874 c.66A>G synonymous_variant 0.2 linezolid
rplC 800877 c.69A>C synonymous_variant 0.2 linezolid
rplC 800880 c.72A>G synonymous_variant 0.21 linezolid
rplC 800889 c.81C>G synonymous_variant 0.25 linezolid
rplC 800907 c.99C>G synonymous_variant 0.2 linezolid
rplC 800916 c.108A>G synonymous_variant 0.18 linezolid
rplC 801312 c.504G>C synonymous_variant 0.17 linezolid
rplC 801324 c.516T>C synonymous_variant 0.19 linezolid
rplC 801341 p.Leu178His missense_variant 0.16 linezolid
rplC 801348 c.540T>G synonymous_variant 0.18 linezolid
rplC 801357 c.549T>C synonymous_variant 0.2 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.26 linezolid
rplC 801396 c.588T>C synonymous_variant 0.19 linezolid
rplC 801402 c.594T>C synonymous_variant 0.21 linezolid
rplC 801405 c.597T>C synonymous_variant 0.2 linezolid
rplC 801438 c.630T>C synonymous_variant 0.18 linezolid
rplC 801442 p.Ile212Val missense_variant 0.19 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.88 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303509 c.579G>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303512 c.582T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1303534 p.Ser202Ala missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303545 c.615A>G synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303560 c.630G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303575 c.645G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303602 c.672A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303614 c.684C>T synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1303632 c.702T>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303686 c.756C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1303701 c.771C>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303716 c.786C>T synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303728 c.798G>A synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303746 c.816T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.18 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303785 c.855G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303789 p.Ile287Val missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303818 c.888C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1303836 c.906G>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303845 c.915C>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303846 p.Phe306Val missense_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303854 c.924T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303860 c.930A>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1303881 c.951G>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1303884 c.954T>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1303911 c.981G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303914 c.984C>G synonymous_variant 0.36 pretomanid
delamanid
clofazimine
fbiC 1303920 c.990C>G synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303923 c.993C>T synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303929 c.999G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303947 c.1017T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1303948 p.Gly340Arg missense_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1303969 p.Val347Ile missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303973 p.Gly348Ala missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1303981 p.Val351Ile missense_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303995 c.1065C>T synonymous_variant 0.24 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304008 c.1078T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304034 c.1104A>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304040 c.1110C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304046 c.1116C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304049 c.1119T>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304058 c.1128G>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304059 c.1129C>T synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304064 c.1134G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304067 c.1137G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304080 p.Ala384Ser missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304559 p.Glu543Asp missense_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304565 c.1635C>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304568 c.1638T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304658 c.1728C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304703 c.1773C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304715 c.1785G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304742 c.1812T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304754 c.1824G>A synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304790 c.1860C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304808 c.1878C>G synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.39 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.55 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.36 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.36 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.68 pretomanid
delamanid
clofazimine
fbiC 1304862 c.1932G>A synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304883 p.Glu651Asp missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304891 p.Ile654Thr missense_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.38 pretomanid
delamanid
clofazimine
fbiC 1304907 c.1977C>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304910 c.1980G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304916 c.1986T>C synonymous_variant 0.32 pretomanid
delamanid
clofazimine
fbiC 1304928 c.1998T>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
embR 1417019 p.Cys110Tyr missense_variant 0.86 ethambutol Not assoc w R
embR 1417554 c.-207C>G upstream_gene_variant 0.88 ethambutol
embR 1417793 c.-446C>T upstream_gene_variant 0.96 ethambutol
atpE 1461185 c.141G>C synonymous_variant 0.21 bedaquiline
atpE 1461189 c.145C>T synonymous_variant 0.2 bedaquiline
atpE 1461194 c.150C>T synonymous_variant 0.21 bedaquiline
atpE 1461197 c.153A>G synonymous_variant 0.24 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.2 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.28 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.26 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473123 n.1278A>G non_coding_transcript_exon_variant 0.55 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473660 n.3G>A non_coding_transcript_exon_variant 0.68 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
inhA 1674280 c.79C>A synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674507 c.306G>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674537 c.336C>G synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674542 p.Ala114Glu missense_variant 0.26 isoniazid
ethionamide
inhA 1674549 c.348G>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674555 c.354G>A synonymous_variant 0.26 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674582 c.381T>C synonymous_variant 0.31 isoniazid
ethionamide
inhA 1674585 c.384T>C synonymous_variant 0.3 isoniazid
ethionamide
inhA 1674589 p.Met130Leu missense_variant 0.3 isoniazid
ethionamide
inhA 1674624 c.423A>C synonymous_variant 0.36 isoniazid
ethionamide
inhA 1674627 c.426T>G synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674630 c.429C>G synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674636 c.435C>G synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674654 c.453G>C synonymous_variant 0.33 isoniazid
ethionamide
inhA 1674693 c.492C>G synonymous_variant 0.23 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.23 isoniazid
ethionamide
rpsA 1833541 c.-1T>C upstream_gene_variant 0.17 pyrazinamide
rpsA 1833554 p.Thr5Ala missense_variant 0.21 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.18 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.2 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.16 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.21 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.37 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.36 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.4 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.32 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.38 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.37 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.3 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.34 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.24 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
rpsA 1834186 c.645C>G synonymous_variant 0.28 pyrazinamide
rpsA 1834189 c.648G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834201 c.660C>T synonymous_variant 0.29 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.25 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834261 c.720A>C synonymous_variant 0.3 pyrazinamide
rpsA 1834264 c.723G>C synonymous_variant 0.32 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.29 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.24 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.34 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.31 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.3 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.25 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834594 c.1053C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.19 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.2 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.22 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.32 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.33 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.23 linezolid
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.21 linezolid
tsnR 1853384 c.-222G>C upstream_gene_variant 0.21 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.24 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.24 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.25 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.24 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.25 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.19 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.21 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.2 linezolid
tsnR 1853485 c.-121G>C upstream_gene_variant 0.16 linezolid
tsnR 1853974 c.369C>T synonymous_variant 0.97 linezolid Not assoc w R
tsnR 1854045 p.Tyr147Cys missense_variant 0.92 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 0.99 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 0.98 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 0.86 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Not assoc w R
amikacin Not assoc w R
bacA 2064912 c.-184A>G upstream_gene_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064933 c.-205A>G upstream_gene_variant 0.2 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064948 c.-220G>C upstream_gene_variant 0.21 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064972 c.-244T>C upstream_gene_variant 0.18 kanamycin
capreomycin
streptomycin
amikacin
ndh 2102212 c.831G>C synonymous_variant 0.18 isoniazid
delamanid
ethionamide
ndh 2102218 c.825C>G synonymous_variant 0.22 isoniazid
delamanid
ethionamide
ndh 2102233 c.810G>A synonymous_variant 0.31 isoniazid Not assoc w R - Interim
delamanid
ethionamide Not assoc w R - Interim
ndh 2102242 c.801G>A synonymous_variant 0.26 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 0.75 isoniazid Not assoc w R
katG 2155054 p.Tyr353Phe missense_variant 0.19 isoniazid
katG 2155056 c.1056A>G synonymous_variant 0.2 isoniazid
katG 2155062 c.1050T>C synonymous_variant 0.2 isoniazid
katG 2155065 c.1047C>G synonymous_variant 0.2 isoniazid
katG 2155068 c.1044T>C synonymous_variant 0.2 isoniazid
katG 2155071 c.1041T>C synonymous_variant 0.2 isoniazid
katG 2155080 c.1032G>C synonymous_variant 0.25 isoniazid
katG 2155113 c.999C>G synonymous_variant 0.22 isoniazid
katG 2155632 c.480A>C synonymous_variant 0.21 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.23 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.24 isoniazid Uncertain significance
katG 2155691 c.421T>C synonymous_variant 0.2 isoniazid
katG 2155695 c.417C>G synonymous_variant 0.19 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.2 isoniazid
PPE35 2167926 p.Leu896Ser missense_variant 0.84 pyrazinamide Not assoc w R
PPE35 2167983 p.Gly877Asp missense_variant 0.83 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 0.76 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
pncA 2289991 c.-750G>C upstream_gene_variant 0.22 pyrazinamide
pncA 2289994 c.-753A>G upstream_gene_variant 0.21 pyrazinamide
pncA 2289997 c.-756G>C upstream_gene_variant 0.18 pyrazinamide
pncA 2290015 c.-774A>C upstream_gene_variant 0.19 pyrazinamide
pncA 2290027 c.-786G>A upstream_gene_variant 0.17 pyrazinamide
pncA 2290030 c.-791_-789delAATinsCAC upstream_gene_variant 0.22 pyrazinamide
pncA 2290033 c.-792C>G upstream_gene_variant 0.22 pyrazinamide
pncA 2290038 c.-797G>T upstream_gene_variant 0.18 pyrazinamide
pncA 2290042 c.-801T>C upstream_gene_variant 0.2 pyrazinamide
kasA 2517947 c.-168C>T upstream_gene_variant 0.24 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.24 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.18 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.88 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.22 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.22 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.23 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.19 isoniazid
kasA 2518561 c.447T>C synonymous_variant 0.19 isoniazid
kasA 2518567 c.453G>C synonymous_variant 0.19 isoniazid
kasA 2518574 p.Ile154Val missense_variant 0.18 isoniazid
kasA 2518588 c.474T>C synonymous_variant 0.19 isoniazid
kasA 2518609 p.Met165Ile missense_variant 0.22 isoniazid
kasA 2518621 c.507G>A synonymous_variant 0.18 isoniazid
kasA 2518642 c.528A>G synonymous_variant 0.21 isoniazid
kasA 2518663 c.549T>C synonymous_variant 0.21 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.21 isoniazid
kasA 2518687 c.573C>T synonymous_variant 0.18 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.2 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.18 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.17 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.17 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.21 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.24 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.22 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.25 isoniazid
kasA 2518816 c.702C>A synonymous_variant 0.25 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.23 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.25 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.2 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.17 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 0.91 isoniazid
ahpC 2726336 c.144G>C synonymous_variant 0.17 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.21 isoniazid
ahpC 2726579 c.387T>C synonymous_variant 0.18 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 0.2 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.2 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.2 isoniazid
ahpC 2726612 c.420C>G synonymous_variant 0.18 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.24 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.26 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.24 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.2 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ahpC 2726696 c.504C>G synonymous_variant 0.17 isoniazid
folC 2747059 c.540T>C synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747065 c.534C>G synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747086 c.513A>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747089 c.510G>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747098 c.501C>G synonymous_variant 0.22 para-aminosalicylic_acid
folC 2747101 c.498G>C synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747107 c.492G>C synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747110 c.489T>C synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747113 c.486C>G synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747116 c.483G>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.17 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.16 para-aminosalicylic_acid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782510 c.1533G>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782528 c.1515G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782537 c.1506T>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783035 c.1008G>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.22 kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin Uncertain significance
Rv2477c 2783044 c.999G>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.22 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783116 c.927T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 p.Thr301Met missense_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783320 c.723C>T synonymous_variant 0.24 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783332 c.711T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783365 c.678C>T synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783373 p.Glu224Gln missense_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783425 p.Pro206Ala missense_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Uncertain significance
ethambutol Uncertain significance
amikacin
Rv2477c 2783432 p.Ser204Thr missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783434 c.609C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783440 c.603T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783461 c.582T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783485 c.558G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783494 c.549C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.21 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783629 c.414C>T synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.2 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.39 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.41 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783920 c.123G>C synonymous_variant 0.45 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783926 c.117C>T synonymous_variant 0.34 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.38 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.35 kanamycin Not assoc w R - Interim
levofloxacin
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.2 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2784375 c.-333T>C upstream_gene_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784381 c.-339T>C upstream_gene_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784396 c.-354A>C upstream_gene_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784428 c.-386T>C upstream_gene_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784429 c.-387A>G upstream_gene_variant 0.22 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784432 c.-390A>C upstream_gene_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2681 2996912 c.174C>T synonymous_variant 0.77 capreomycin Not assoc w R
Rv2752c 3064632 c.1560C>T synonymous_variant 0.9 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
Rv2752c 3064995 c.1197C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3064998 c.1194A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065018 p.Asn392His missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065028 c.1164G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065925 p.Ala89Gly missense_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065928 c.264G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3065947 p.Gly82Ala missense_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065955 c.235_237delTTGinsCTC synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065979 c.213T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065993 p.Val67Ile missense_variant 0.2 levofloxacin
moxifloxacin
isoniazid Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
Rv2752c 3065994 c.198T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3065997 c.195C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066002 p.Met64Leu missense_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066024 c.168T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066040 p.Gly51Thr missense_variant 0.24 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066042 c.150T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066050 p.Leu48Met missense_variant 0.28 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066054 c.138T>G synonymous_variant 0.32 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066066 c.126T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066075 c.117A>G synonymous_variant 0.29 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066087 c.105A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
Rv2752c 3066117 p.Asn25Ser missense_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066294 c.-103C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066300 c.-109G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066303 c.-112C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066309 c.-118T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066336 c.-145C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066345 c.-154C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066350 c.-159T>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066543 c.-352C>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.22 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066583 c.-392C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066589 c.-398G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066603 c.-412A>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067316 c.630A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.28 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.38 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.28 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.25 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067682 c.264G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067685 c.261A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067688 c.258G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067826 c.120C>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.18 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.25 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.28 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.16 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3448714 p.Asp71His missense_variant 0.91 ethionamide Uncertain significance
Rv3236c 3612643 c.474A>G synonymous_variant 0.21 pyrazinamide
Rv3236c 3612667 c.450T>G synonymous_variant 0.21 pyrazinamide
Rv3236c 3612673 c.444G>C synonymous_variant 0.17 pyrazinamide
lpqB 3624082 c.829A>C synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624094 c.817A>C synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624100 c.811T>C synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624107 c.804C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624119 c.792C>G synonymous_variant 0.27 rifampicin
bedaquiline
lpqB 3624124 p.Leu263Val missense_variant 0.26 rifampicin
bedaquiline
lpqB 3624125 c.786A>G synonymous_variant 0.26 rifampicin
bedaquiline
lpqB 3624236 c.675C>A synonymous_variant 0.85 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624371 c.540T>G synonymous_variant 0.17 rifampicin
bedaquiline
lpqB 3624389 c.522C>G synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624401 c.510C>T synonymous_variant 0.22 rifampicin
bedaquiline
lpqB 3624407 c.504C>G synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624422 c.489G>C synonymous_variant 0.25 rifampicin
bedaquiline
lpqB 3624425 p.Glu162Ala missense_variant 0.25 rifampicin
bedaquiline
lpqB 3624428 c.483A>G synonymous_variant 0.24 rifampicin
bedaquiline
lpqB 3624452 c.459T>C synonymous_variant 0.24 rifampicin
bedaquiline
lpqB 3624464 c.447A>G synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624470 c.441T>C synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624476 c.435C>G synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624485 p.Asp142Gly missense_variant 0.17 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3624491 c.420G>C synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624701 c.210T>C synonymous_variant 0.2 rifampicin
bedaquiline
lpqB 3624713 c.198C>T synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624722 c.189C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625569 c.1045T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625572 p.Thr348Ser missense_variant 0.28 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3625592 p.Ser341Asn missense_variant 0.23 rifampicin
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.3 rifampicin
bedaquiline
lpqB 3625612 c.-702G>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.29 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.29 rifampicin
bedaquiline
lpqB 3625627 c.-717C>T upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625648 c.-738T>C upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.27 rifampicin
bedaquiline
lpqB 3625669 c.-759G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
lpqB 3625687 c.-777G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
lpqB 3625696 c.-786A>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3625705 c.909C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625714 c.-804C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625735 c.879C>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.26 rifampicin Uncertain significance
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625797 p.Val273Met missense_variant 0.3 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625840 c.-930A>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3625852 c.762A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625864 c.-954T>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3625876 c.738G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625888 c.-978G>T upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626840 c.-227C>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627065 c.-452G>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrA 3627068 c.282T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627074 c.-461G>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3627080 c.270T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.38 rifampicin
bedaquiline
mtrA 3627119 c.231T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627122 c.-509T>C upstream_gene_variant 0.33 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3627139 c.-526T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627167 c.-554T>C upstream_gene_variant 0.39 rifampicin
bedaquiline
mtrB 3627170 c.-557C>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.32 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627191 c.-578G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627197 c.-584T>C upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3627227 c.123T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627233 c.-620T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627236 c.-623T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3627296 c.-683T>C upstream_gene_variant 0.29 rifampicin
bedaquiline
mtrB 3627299 c.-688_-686delTTGinsCTC upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627314 c.-701C>T upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3627317 c.-704T>C upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrA 3627343 p.Thr3Ser missense_variant 0.17 rifampicin
bedaquiline
fbiB 3642614 c.1080C>T synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiB 3642620 c.1086T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiB 3642656 c.1122G>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiB 3642662 c.1128C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiB 3642677 c.1143A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiB 3642680 c.1146A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiB 3642684 c.1150T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
rpoA 3877503 c.1005G>C synonymous_variant 0.2 rifampicin
rpoA 3877507 p.Gly334Ala missense_variant 0.21 rifampicin
rpoA 3877515 c.993G>C synonymous_variant 0.26 rifampicin
rpoA 3877542 c.966C>T synonymous_variant 0.2 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.28 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.2 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.27 rifampicin
rpoA 3877677 p.Ala277Thr missense_variant 0.18 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.3 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.27 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.33 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.18 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.19 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.32 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.29 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.25 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.31 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.31 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.28 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.25 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.27 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.25 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.22 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.2 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.19 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.21 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.2 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.2 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.2 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.23 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.23 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.2 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.28 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.25 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.2 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.19 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.21 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.23 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.2 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.22 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.22 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.24 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.2 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.3 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.28 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.24 rifampicin
rpoA 3878472 p.Asp12Glu missense_variant 0.23 rifampicin
rpoA 3878478 c.30C>G synonymous_variant 0.2 rifampicin
rpoA 3878490 c.18C>A synonymous_variant 0.2 rifampicin
rpoA 3878496 c.12A>T synonymous_variant 0.18 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.19 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.21 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878914 c.-407T>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878947 c.-440G>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878968 c.-461T>G upstream_gene_variant 0.2 rifampicin
rpoA 3878976 c.-469A>G upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878998 c.-491C>G upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3879013 c.-506A>G upstream_gene_variant 0.22 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.22 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.21 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.24 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.33 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.31 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.26 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.2 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.2 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.18 rifampicin
ddn 3986648 c.-196C>G upstream_gene_variant 0.24 pretomanid
delamanid
ddn 3986655 c.-189A>T upstream_gene_variant 0.15 pretomanid
delamanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.2 pretomanid
delamanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.19 pretomanid
delamanid
clpC1 4038271 p.Pro812Ala missense_variant 0.25 pyrazinamide
clpC1 4038272 p.Gly811Ser missense_variant 0.25 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.3 pyrazinamide
clpC1 4038308 p.Val799Ile missense_variant 0.21 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.24 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.22 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038445 p.Ala754Thr missense_variant 0.15 pyrazinamide
clpC1 4038462 p.Ala748Glu missense_variant 0.16 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.29 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.39 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.41 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.29 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.24 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.17 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.26 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.25 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.41 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.43 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.4 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.29 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.38 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.34 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039127 c.1578G>A synonymous_variant 0.21 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.3 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039187 c.1518G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.24 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.19 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.19 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.17 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.28 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.42 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.34 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039789 p.Ser306Thr missense_variant 0.15 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.17 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.24 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.37 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.27 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.21 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.28 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.3 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.32 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.21 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040171 c.534C>G synonymous_variant 0.2 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040213 c.490_492delTCTinsAGC synonymous_variant 0.2 pyrazinamide
clpC1 4040225 c.480A>C synonymous_variant 0.24 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.29 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.33 pyrazinamide
clpC1 4040264 c.441C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040267 c.438A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.32 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.28 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.24 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.21 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.26 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.33 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.38 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>A synonymous_variant 0.32 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4040517 p.Val63Ala missense_variant 0.64 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.2 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040546 c.159G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.22 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.21 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040662 c.43C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040699 c.6C>T synonymous_variant 0.19 pyrazinamide
clpC1 4040711 c.-7G>A upstream_gene_variant 0.18 pyrazinamide
panD 4044138 c.144T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
panD 4044150 c.132A>G synonymous_variant 0.2 pyrazinamide
panD 4044712 c.-431C>A upstream_gene_variant 0.19 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.24 pyrazinamide
panD 4044746 c.-467_-465delGTGinsATC upstream_gene_variant 0.23 pyrazinamide
panD 4044749 c.-468G>A upstream_gene_variant 0.18 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.22 pyrazinamide
panD 4044755 c.-474G>C upstream_gene_variant 0.19 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.21 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.23 pyrazinamide
panD 4044989 c.-710_-708delGGTinsAGC upstream_gene_variant 0.2 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.22 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.27 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.27 pyrazinamide
panD 4045034 c.-753A>T upstream_gene_variant 0.2 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.29 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.25 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 0.97 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
glpK 4138568 c.1188A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138571 c.1185C>G synonymous_variant 0.3 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138583 c.1173G>C synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138586 c.1170C>T synonymous_variant 0.26 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138594 p.Asn388Asp missense_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138606 c.1150T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138631 c.1125C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138634 c.1122G>T synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138643 c.1113A>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138681 p.Met359Val missense_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138695 p.Pro354Asp missense_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138718 c.1038T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138724 c.1032A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138757 c.999A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139581 p.Asn59Asp missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
isoniazid Uncertain significance
streptomycin Uncertain significance
rifampicin Uncertain significance
ethambutol Uncertain significance
glpK 4139588 c.168G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139597 c.159C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139630 c.126C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139651 p.His35Gln missense_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240543 c.681G>C synonymous_variant 0.17 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.91 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.17 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.18 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.28 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.28 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.27 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.27 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.27 ethambutol
embC 4240867 c.1005T>G synonymous_variant 0.18 ethambutol
embC 4240870 c.1008T>C synonymous_variant 0.2 ethambutol
embC 4240879 c.1017G>C synonymous_variant 0.21 ethambutol
embC 4240880 p.Ala340Thr missense_variant 0.2 ethambutol Uncertain significance
embC 4240885 c.1023T>C synonymous_variant 0.19 ethambutol
embC 4240897 c.1035C>G synonymous_variant 0.19 ethambutol Not assoc w R
embC 4240900 c.1038A>G synonymous_variant 0.17 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.18 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.18 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.17 ethambutol
embC 4241042 p.Asn394Asp missense_variant 0.8 ethambutol Not assoc w R
embC 4241050 c.1188T>G synonymous_variant 0.19 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.21 ethambutol
embC 4241137 c.1275G>C synonymous_variant 0.18 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.18 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 0.25 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.26 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.18 ethambutol
embC 4241380 c.1518A>C synonymous_variant 0.17 ethambutol
embC 4241394 p.Lys511Ser missense_variant 0.21 ethambutol
embC 4241443 c.1581C>G synonymous_variant 0.23 ethambutol
embC 4241449 c.1587C>G synonymous_variant 0.26 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.24 ethambutol
embC 4241473 c.1611G>A synonymous_variant 0.17 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.17 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.17 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.18 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.22 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.23 ethambutol
embC 4241617 c.1755G>A synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4241623 c.1761C>G synonymous_variant 0.2 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.23 ethambutol
embC 4241644 c.1782G>C synonymous_variant 0.27 ethambutol
embC 4241648 c.1786T>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embC 4241657 p.Ser599Pro missense_variant 0.23 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.96 ethambutol Not assoc w R
embA 4243848 p.Val206Met missense_variant 0.91 ethambutol Not assoc w R
embA 4245083 c.1851A>C synonymous_variant 0.27 ethambutol
embA 4245089 c.1857G>C synonymous_variant 0.26 ethambutol
embA 4245092 c.1860C>G synonymous_variant 0.26 ethambutol
embA 4245101 c.1869G>C synonymous_variant 0.28 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.32 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.32 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.27 ethambutol
embA 4245194 c.1962G>C synonymous_variant 0.26 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.28 ethambutol
embA 4245206 c.1974A>G synonymous_variant 0.2 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.23 ethambutol
embA 4245215 c.1983A>G synonymous_variant 0.2 ethambutol
embA 4245222 p.Tyr664Gln missense_variant 0.23 ethambutol
embB 4245587 c.-927G>C upstream_gene_variant 0.21 ethambutol
embB 4245593 c.-921C>G upstream_gene_variant 0.21 ethambutol
embA 4245594 p.Ser788Thr missense_variant 0.21 ethambutol
embB 4245599 c.-915A>G upstream_gene_variant 0.21 ethambutol
embB 4245620 c.-894T>C upstream_gene_variant 0.23 ethambutol
embA 4245623 c.2391G>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4245626 c.-888G>C upstream_gene_variant 0.23 ethambutol
embA 4245643 p.Ala804Val missense_variant 0.23 ethambutol
embA 4245648 p.Ile806Tyr missense_variant 0.19 ethambutol
embA 4245652 p.Thr807Ser missense_variant 0.17 ethambutol
embB 4245659 c.-855C>G upstream_gene_variant 0.19 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.17 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.19 ethambutol
embA 4245771 p.Asn847Ser missense_variant 0.15 ethambutol Uncertain significance
embB 4245807 c.-707_-705delTTAinsCTG upstream_gene_variant 0.19 ethambutol
embA 4245820 p.Ser863Thr missense_variant 0.22 ethambutol
embB 4245830 c.-684G>C upstream_gene_variant 0.25 ethambutol
embB 4245845 c.-669T>G upstream_gene_variant 0.24 ethambutol
embB 4245848 c.-666C>G upstream_gene_variant 0.24 ethambutol
embB 4245860 c.-654C>G upstream_gene_variant 0.23 ethambutol
embA 4245969 p.Pro913Ser missense_variant 0.78 ethambutol Not assoc w R
embB 4247356 c.843C>T synonymous_variant 0.82 ethambutol Not assoc w R - Interim
embB 4247395 c.882C>G synonymous_variant 0.17 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.19 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.22 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.25 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.24 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.28 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.24 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.21 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.23 ethambutol
embB 4247646 p.Glu378Ala missense_variant 0.94 ethambutol Not assoc w R
embB 4247819 p.Val436Ile missense_variant 0.22 ethambutol Uncertain significance
embB 4247836 c.1323A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248035 p.Val508Ile missense_variant 0.17 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.16 ethambutol Uncertain significance
embB 4248070 c.1557T>C synonymous_variant 0.21 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.26 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.26 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.18 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.25 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.27 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.27 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4248206 p.Ser565Gly missense_variant 0.34 ethambutol Uncertain significance
embB 4248220 c.1707A>G synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.22 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.17 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.3 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.2 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.33 ethambutol
embB 4248322 c.1809G>C synonymous_variant 0.17 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.27 ethambutol
embB 4248346 c.1833G>C synonymous_variant 0.17 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.2 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.19 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.2 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.2 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.16 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.18 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.19 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.