TB-Profiler result

Run: SAMEA2533358
Summary

Run ID: SAMEA2533358

Sample name:

Date: 2024-03-25T22:43:21.250113

Number of reads: 2507510

Percentage reads mapped: 78.8

Median coverage: 84.0

Strain: lineage4.1.1.3

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.97
lineage4.1.1.3 Euro-American (X-type) RD193 0.98
lineage4 Euro-American None 1.0
lineage4.1.1 Euro-American (X-type) None 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser450Leu Assoc w R
isoniazid inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embA c.-16C>G Uncertain significance Mutation from literature
embB p.Met306Ile Assoc w R
p.His312Arg Mutation from literature
pyrazinamide pncA p.Arg154Gly Assoc w R
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
n.878G>A Assoc w R - Interim
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine ald c.464delG Mutation from literature
ethionamide inhA c.-777C>T Assoc w R Alias fabG1_c.-15C>T
ethA c.1192_1194dupGTG Mutation from literature
c.869dupA Assoc w R
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761155 p.Ser450Leu missense_variant 0.81 rifampicin Assoc w R
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance Mutation from literature
rrs 1472723 n.878G>A non_coding_transcript_exon_variant 0.8 streptomycin Assoc w R - Interim
inhA 1673425 c.-777C>T upstream_gene_variant 1.0 isoniazid Assoc w R Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance)
ethionamide Assoc w R Alias fabG1_c.-15C>T
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
pncA 2288782 p.Arg154Gly missense_variant 1.0 pyrazinamide Assoc w R
ald 3087278 c.464delG frameshift_variant 1.0 cycloserine Mutation from literature
embA 4243217 c.-16C>G upstream_gene_variant 1.0 ethambutol Uncertain significance Mutation from literature
embB 4247431 p.Met306Ile missense_variant 0.77 ethambutol Assoc w R
embB 4247448 p.His312Arg missense_variant 0.25 ethambutol Mutation from literature
ethA 4326279 c.1192_1194dupGTG conservative_inframe_insertion 0.97 ethionamide Mutation from literature
ethA 4326604 c.869dupA frameshift_variant 1.0 ethionamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1137 c.1137C>G synonymous_variant 0.15 isoniazid
dnaA 1149 c.1149C>G synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 1152 c.1152A>G synonymous_variant 0.16 isoniazid
dnaA 1153 c.1153T>C synonymous_variant 0.16 isoniazid
dnaA 1161 c.1161A>G synonymous_variant 0.16 isoniazid
dnaA 1164 c.1164A>G synonymous_variant 0.16 isoniazid
dnaA 1167 c.1167A>G synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 1176 c.1176A>G synonymous_variant 0.16 isoniazid
dnaA 1197 c.1197T>G synonymous_variant 0.16 isoniazid
dnaA 1230 c.1230A>G synonymous_variant 0.18 isoniazid
dnaA 1242 c.1242G>C synonymous_variant 0.17 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>G synonymous_variant 0.18 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.15 isoniazid
dnaA 1374 c.1374G>A synonymous_variant 0.14 isoniazid
dnaA 1383 c.1383A>G synonymous_variant 0.16 isoniazid
gyrB 6178 c.939C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6215 p.Ser326Thr missense_variant 0.22 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6235 c.996C>A synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrB 6238 c.999G>A synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Lys missense_variant 0.23 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6268 c.1029C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6334 c.-968G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6346 c.-956C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6889 c.-413G>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6904 c.-398C>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6910 c.-392G>A upstream_gene_variant 0.14 levofloxacin
moxifloxacin
gyrA 7078 c.-224A>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7084 c.-218A>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7114 c.-188C>A upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 7124 c.1885_1887delTCGinsAT frameshift_variant&missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin
gyrA 7129 c.-173T>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.24 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7165 c.-137C>G upstream_gene_variant 0.21 levofloxacin
moxifloxacin
gyrA 7177 c.-125G>A upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7391 c.90C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7394 c.93T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7406 c.105G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7427 c.126G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7442 c.141G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7451 c.150C>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7457 c.156T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 7475 c.174A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7490 c.189C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7547 c.246C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8177 c.876A>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8405 c.1104C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8459 c.1158G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8465 c.1164C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8864 c.1563C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8903 c.1602T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8948 p.Leu549Phe missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9128 c.1827C>A synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9179 c.1878C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9252 p.Val651Ile missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9268 p.Asn656Ser missense_variant 0.24 levofloxacin
moxifloxacin
gyrA 9275 c.1974G>A synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9293 c.1992G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 9315 c.2014C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9345 c.2044A>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9365 c.2064G>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9374 c.2073G>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9377 c.2076A>G synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9383 c.2082T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9386 c.2085T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9395 c.2094G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9398 c.2097T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9429 p.Arg710Tyr missense_variant 0.15 levofloxacin
moxifloxacin
gyrA 9443 c.2142G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9479 c.2178G>T synonymous_variant 0.14 levofloxacin
moxifloxacin
mshA 575734 c.387T>G synonymous_variant 0.16 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.18 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.18 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.17 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.16 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.16 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.18 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.18 ethionamide
isoniazid
mshA 575824 c.477T>A synonymous_variant 0.17 ethionamide
isoniazid
mshA 575845 c.498C>G synonymous_variant 0.21 ethionamide
isoniazid
ccsA 620288 p.Arg133Gln missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620295 c.405G>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>G synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620724 c.834C>T synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620758 c.868_870delCGCinsAG frameshift_variant&missense_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620763 c.873G>A synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>A synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620787 c.897C>G synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620790 c.900C>T synonymous_variant 0.17 capreomycin
amikacin
kanamycin
Rv0565c 656371 p.Pro367His missense_variant 0.16 ethionamide
Rv0565c 656400 c.1071G>T synonymous_variant 0.15 ethionamide
Rv0565c 657269 p.Ser68Pro missense_variant 0.94 ethionamide Uncertain significance
hadA 732304 c.375C>T synonymous_variant 0.15 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.16 isoniazid
hadA 732319 c.390G>A synonymous_variant 0.17 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.16 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.17 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.17 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.21 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.23 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.26 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.26 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.26 isoniazid
nusG 734532 c.279A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.24 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.24 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>T synonymous_variant 0.27 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.26 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.23 rifampicin
nusG 734631 c.378G>C synonymous_variant 0.19 rifampicin
nusG 734637 c.384G>C synonymous_variant 0.2 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.19 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.19 rifampicin
nusG 734667 c.414C>A synonymous_variant 0.15 rifampicin
nusG 734750 p.Ser166Thr missense_variant 0.15 rifampicin
rpoB 760139 c.333A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.17 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.17 rifampicin
rpoB 760283 c.477G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.19 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.19 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.18 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.19 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.21 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.21 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.21 rifampicin
rpoB 760415 c.609C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760457 c.651C>G synonymous_variant 0.2 rifampicin
rpoB 760463 c.657C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760487 c.681G>C synonymous_variant 0.19 rifampicin
rpoB 760514 c.708C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760520 c.714C>G synonymous_variant 0.17 rifampicin
rpoB 760522 p.Ser239Asn missense_variant 0.17 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.15 rifampicin
rpoB 760547 c.741G>T synonymous_variant 0.19 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.25 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.24 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.19 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.16 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.19 rifampicin
rpoB 760755 c.949_951delCATinsAC frameshift_variant&missense_variant 0.18 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.19 rifampicin
rpoB 760776 p.Ser324Thr missense_variant 0.15 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.17 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.16 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.17 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.16 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.19 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.22 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ser missense_variant 0.22 rifampicin
rpoB 760886 c.1080A>G synonymous_variant 0.27 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.26 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.26 rifampicin
rpoB 760928 c.1122G>T synonymous_variant 0.25 rifampicin
rpoB 760931 c.1125C>G synonymous_variant 0.27 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.25 rifampicin
rpoB 760982 c.1176G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.26 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.28 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.29 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.2 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.21 rifampicin
rpoB 761234 c.1428G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761264 c.1458C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761300 c.1494G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761318 c.1512G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>G synonymous_variant 0.16 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.15 rifampicin
rpoB 761636 c.1830G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.17 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761669 c.1863C>T synonymous_variant 0.17 rifampicin
rpoB 761675 c.1869G>C synonymous_variant 0.18 rifampicin
rpoB 761711 c.1905C>G synonymous_variant 0.19 rifampicin
rpoB 761717 c.1911C>G synonymous_variant 0.17 rifampicin
rpoB 761723 c.1917_1919delAGAinsT frameshift_variant&missense_variant 0.16 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.16 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.16 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.16 rifampicin
rpoB 761815 p.Ala670Asp missense_variant 0.14 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.14 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.15 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.24 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.26 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.25 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.26 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.25 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762285 p.Arg827Cys missense_variant 0.73 rifampicin Uncertain significance
rpoB 762293 c.2487T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.26 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.25 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.23 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.23 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.27 rifampicin
rpoC 762407 c.-963G>A upstream_gene_variant 0.25 rifampicin
rpoC 762410 c.-960T>C upstream_gene_variant 0.25 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 762434 c.-936T>C upstream_gene_variant 0.21 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.17 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.16 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.17 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.17 rifampicin
rpoB 762750 p.Leu982Met missense_variant 0.19 rifampicin
rpoB 762753 c.2947T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762758 c.-612G>C upstream_gene_variant 0.22 rifampicin
rpoB 762785 p.Asp993Glu missense_variant 0.26 rifampicin Uncertain significance
rpoB 762788 c.2982G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762789 p.Leu995Met missense_variant 0.24 rifampicin Uncertain significance
rpoB 762795 p.Asp997Asn missense_variant 0.24 rifampicin Uncertain significance
rpoB 762799 p.Ala998Gly missense_variant 0.23 rifampicin Uncertain significance
rpoB 762812 c.3006C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762813 p.Met1003Val missense_variant 0.24 rifampicin
rpoB 762818 c.3012C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762827 c.3021G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762947 c.-423C>G upstream_gene_variant 0.2 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.17 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763139 c.-231C>T upstream_gene_variant 0.24 rifampicin
rpoC 763148 c.-222G>C upstream_gene_variant 0.25 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.26 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763181 c.-189G>C upstream_gene_variant 0.18 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.25 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>T synonymous_variant 0.21 rifampicin
rpoC 763573 c.204G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763576 c.207C>G synonymous_variant 0.22 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763624 c.255C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.22 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.15 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.15 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.17 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.19 rifampicin
rpoC 764140 c.771C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764203 c.834G>T synonymous_variant 0.15 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764213 p.Arg282Lys missense_variant 0.16 rifampicin Uncertain significance
rpoC 764257 c.888G>C synonymous_variant 0.15 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764320 c.951C>G synonymous_variant 0.17 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.16 rifampicin
rpoC 764387 c.1018T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764419 c.1050C>G synonymous_variant 0.21 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.21 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.21 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.23 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.19 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.18 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.23 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>G synonymous_variant 0.23 rifampicin
rpoC 764935 c.1566T>C synonymous_variant 0.23 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765379 c.2010G>T synonymous_variant 0.14 rifampicin
rpoC 765385 p.Met672Ile missense_variant 0.15 rifampicin
rpoC 765394 c.2025G>A synonymous_variant 0.18 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.16 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.17 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.17 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765466 c.2097C>T synonymous_variant 0.23 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.28 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.26 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.28 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.29 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.24 rifampicin
rpoC 765583 c.2214G>C synonymous_variant 0.24 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.25 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.23 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765688 c.2319G>A synonymous_variant 0.25 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.25 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.26 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.25 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.24 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.28 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.26 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.29 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.27 rifampicin
rpoC 765811 c.2442T>G synonymous_variant 0.26 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.22 rifampicin
rpoC 765928 c.2559C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766000 c.2631G>T synonymous_variant 0.19 rifampicin
rpoC 766009 c.2640G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.18 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.18 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.17 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.15 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.15 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.16 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766390 c.3021C>T synonymous_variant 0.15 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.22 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.2 rifampicin
rpoC 766462 c.3093G>T synonymous_variant 0.16 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.15 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.16 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.15 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.15 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.16 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.17 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.22 rifampicin
rpoC 766630 c.3261G>T synonymous_variant 0.18 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.19 rifampicin
rpoC 766666 c.3297C>G synonymous_variant 0.19 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.2 rifampicin
rpoC 766693 c.3324C>T synonymous_variant 0.21 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.18 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.2 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.25 rifampicin
rpoC 766801 c.3432C>A synonymous_variant 0.29 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.3 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.35 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.34 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.35 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.33 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766951 c.3582G>C synonymous_variant 0.27 rifampicin
rpoC 766963 c.3594T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766978 c.3609C>A synonymous_variant 0.29 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.28 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.29 rifampicin
rpoC 767065 c.3696G>T synonymous_variant 0.3 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.29 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.23 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.21 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767278 c.3909T>C synonymous_variant 0.16 rifampicin
rpoC 767281 c.3912C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767284 c.3915C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781435 c.-125G>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781679 c.120C>T synonymous_variant 0.15 streptomycin Not assoc w R - Interim
rpsL 781682 c.123T>C synonymous_variant 0.16 streptomycin
rpsL 781712 c.153G>A synonymous_variant 0.17 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.17 streptomycin
rpsL 781718 c.159C>A synonymous_variant 0.17 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.19 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.19 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.21 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.22 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.22 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.22 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.21 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.22 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.27 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.26 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.28 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.25 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.25 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.26 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.22 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.22 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.18 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.17 streptomycin Uncertain significance
rplC 800219 c.-590T>C upstream_gene_variant 0.99 linezolid
rplC 800591 c.-218C>T upstream_gene_variant 0.15 linezolid
rplC 800594 c.-215C>T upstream_gene_variant 0.15 linezolid
rplC 800600 c.-209G>T upstream_gene_variant 0.15 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.15 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.15 linezolid
fbiC 1303539 c.609G>A synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303848 c.918C>T synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303897 c.967C>T synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303905 c.975G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303932 c.1002G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>A synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304880 c.1950C>T synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.18 clofazimine
pretomanid
delamanid
atpE 1461132 p.Val30Ile missense_variant 0.17 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472028 n.183A>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185G>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472031 n.186G>A non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472034 n.189T>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472044 n.199G>T non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472300 n.455C>T non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.17 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.19 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473831 n.174G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473966 n.309T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.3 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474036 n.379G>A non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1474964 n.1307T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1475028 n.1371G>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475201 n.1544G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475446 n.1789G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.18 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.21 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1476717 n.3060C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rpsA 1833589 c.48A>T synonymous_variant 0.23 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.23 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833703 c.162C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1833724 c.183C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1833793 c.252C>T synonymous_variant 0.24 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.26 pyrazinamide
rpsA 1833835 c.294C>T synonymous_variant 0.27 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.28 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.25 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.25 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834097 c.556_557delTCinsAG synonymous_variant 0.16 pyrazinamide
rpsA 1834102 c.561T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.22 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.26 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.17 pyrazinamide
tsnR 1853360 c.-246G>A upstream_gene_variant 0.28 linezolid
tsnR 1853361 c.-245T>C upstream_gene_variant 0.32 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.32 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.35 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.31 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.28 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.27 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.24 linezolid
tsnR 1853444 c.-162C>T upstream_gene_variant 0.16 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.16 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517917 c.-198G>T upstream_gene_variant 0.19 isoniazid
kasA 2517947 c.-168C>T upstream_gene_variant 0.17 isoniazid
kasA 2517965 c.-150C>T upstream_gene_variant 0.16 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.26 isoniazid
kasA 2518768 c.654C>G synonymous_variant 0.24 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.21 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.19 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.18 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.17 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.16 isoniazid
kasA 2518834 c.720C>T synonymous_variant 0.14 isoniazid
kasA 2518837 c.723G>A synonymous_variant 0.14 isoniazid
kasA 2518846 c.732G>C synonymous_variant 0.14 isoniazid
Rv2477c 2782936 c.1107G>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782966 c.1077C>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782975 c.1068C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782981 c.1062G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783044 c.999G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783065 c.978C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.23 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783572 c.471A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783695 c.348C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783770 c.273G>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783853 c.190C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784476 c.-434A>G upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784488 c.-446A>C upstream_gene_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784489 c.-447C>G upstream_gene_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784493 c.-451C>A upstream_gene_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784501 c.-459T>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784510 c.-470_-468delAGCinsGT upstream_gene_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784519 c.-477G>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784528 c.-486T>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784551 c.-509G>A upstream_gene_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859903 c.516G>C synonymous_variant 0.17 clofazimine
bedaquiline
Rv2752c 3065457 c.735A>T synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065463 c.729T>C synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065481 c.711T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
Rv2752c 3065553 c.639A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
thyX 3067304 c.642A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067313 c.633G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067316 c.630A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067337 c.609C>T synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073959 c.513T>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073968 c.504C>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.15 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.16 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3624119 c.792C>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624133 c.778A>C synonymous_variant 0.17 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625656 c.958T>C synonymous_variant 0.2 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625687 c.-777G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
lpqB 3625702 c.-792C>T upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625732 c.882C>T synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625755 p.Ala287Thr missense_variant 0.2 bedaquiline
rifampicin Uncertain significance
lpqB 3625762 c.-852A>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrB 3625765 c.849C>G synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625927 c.687T>C synonymous_variant 0.16 bedaquiline
rifampicin
mtrB 3625930 c.684C>G synonymous_variant 0.16 bedaquiline
rifampicin
mtrB 3625936 c.678C>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625942 c.672C>G synonymous_variant 0.16 bedaquiline
rifampicin
mtrB 3625945 c.669A>G synonymous_variant 0.16 bedaquiline
rifampicin
mtrB 3625951 c.663A>G synonymous_variant 0.15 bedaquiline
rifampicin
mtrB 3625968 p.Ala216Thr missense_variant 0.14 bedaquiline
rifampicin
mtrB 3625988 p.Thr209Lys missense_variant 0.14 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3626885 c.-272A>G upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626891 c.-278G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627008 c.-395G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627023 c.-410C>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627056 c.294C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627065 c.-452G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627221 c.129C>T synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627236 c.-623T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.27 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.23 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.17 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.2 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.16 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.16 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.16 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.15 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.15 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.19 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.2 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.22 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.21 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.21 rifampicin
rpoA 3878046 c.462T>C synonymous_variant 0.23 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.23 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.23 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.22 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.21 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.22 rifampicin
rpoA 3878076 c.432C>T synonymous_variant 0.22 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.24 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.24 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.23 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.23 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.25 rifampicin
rpoA 3878130 c.378C>G synonymous_variant 0.25 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.27 rifampicin Uncertain significance
rpoA 3878143 p.Gly122Asp missense_variant 0.27 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>G synonymous_variant 0.21 rifampicin
rpoA 3878187 c.321C>G synonymous_variant 0.21 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.38 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878276 c.232C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.34 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>T synonymous_variant 0.38 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.27 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.19 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.19 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.21 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.2 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.2 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.2 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.21 rifampicin
rpoA 3878397 c.111G>A synonymous_variant 0.21 rifampicin
rpoA 3878716 c.-209C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.23 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.23 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.23 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.21 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.21 rifampicin
rpoA 3878769 c.-262C>A upstream_gene_variant 0.25 rifampicin
rpoA 3878782 c.-275G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878809 c.-302T>C upstream_gene_variant 0.3 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.23 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.27 rifampicin
rpoA 3878837 c.-331_-330delAAinsGG upstream_gene_variant 0.24 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.31 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.29 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.24 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3879050 c.-543A>C upstream_gene_variant 0.25 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.28 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.2 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.19 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.19 rifampicin
rpoA 3879117 c.-610C>T upstream_gene_variant 0.28 rifampicin
ddn 3986636 c.-208C>G upstream_gene_variant 0.15 delamanid
pretomanid
clpC1 4038212 c.2493T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038239 c.2466T>A synonymous_variant 0.29 pyrazinamide
clpC1 4038243 p.Thr821Ile missense_variant 0.29 pyrazinamide
clpC1 4038255 p.Val817Lys missense_variant 0.31 pyrazinamide
clpC1 4038260 c.2445C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4038271 p.Pro812Ala missense_variant 0.31 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.3 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038308 c.2397G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.26 pyrazinamide
clpC1 4038338 c.2367C>T synonymous_variant 0.24 pyrazinamide
clpC1 4038347 c.2358G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.2 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.27 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.25 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.19 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.19 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038677 c.2028G>T synonymous_variant 0.24 pyrazinamide
clpC1 4038683 c.2022T>G synonymous_variant 0.24 pyrazinamide
clpC1 4038695 c.2010C>G synonymous_variant 0.21 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.19 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.21 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038815 c.1890G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.37 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.29 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.28 pyrazinamide
clpC1 4038929 c.1776G>A synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4038953 c.1752A>G synonymous_variant 0.27 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038977 c.1728G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039034 c.1671C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039136 c.1569C>T synonymous_variant 0.17 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039481 c.1224T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039484 c.1221T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039634 c.1071G>A synonymous_variant 0.21 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039670 c.1035G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.21 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.17 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.17 pyrazinamide
clpC1 4040009 c.696C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040030 c.675C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4040048 c.657C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.18 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040144 c.561G>C synonymous_variant 0.16 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040171 c.534C>G synonymous_variant 0.21 pyrazinamide
glpK 4138580 c.1176C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138667 c.1089G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138670 c.1086G>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138679 c.1075_1077delATGinsGC frameshift_variant&missense_variant 0.18 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
glpK 4138682 c.1074C>A synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138695 p.Pro354Asp missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138706 c.1050C>A synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138714 p.Ala348Ser missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138715 c.1041G>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138721 c.1035G>A synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138724 c.1032A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138730 c.1026C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139189 c.567G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139198 c.558C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4139230 p.Pro176Ala missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139231 c.525A>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4240090 c.228C>G synonymous_variant 0.15 ethambutol
embC 4240096 c.234G>C synonymous_variant 0.15 ethambutol
embC 4240105 c.243C>T synonymous_variant 0.16 ethambutol
embC 4240110 p.Asn83Thr missense_variant 0.15 ethambutol
embC 4240112 p.Ile84Val missense_variant 0.15 ethambutol
embC 4240183 c.321A>G synonymous_variant 0.16 ethambutol
embC 4240798 c.936C>T synonymous_variant 0.15 ethambutol
embC 4241002 c.1140G>C synonymous_variant 0.15 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 1.0 ethambutol Not assoc w R
embA 4245056 c.1824C>G synonymous_variant 0.18 ethambutol
embA 4245060 c.1828T>C synonymous_variant 0.18 ethambutol
embA 4245065 c.1833G>A synonymous_variant 0.18 ethambutol
embA 4245078 p.Trp616Val missense_variant 0.18 ethambutol
embA 4245093 p.Ile621Val missense_variant 0.16 ethambutol Uncertain significance
embA 4245101 c.1869G>C synonymous_variant 0.18 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.19 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.18 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.16 ethambutol
embA 4245186 p.Thr652Ala missense_variant 0.15 ethambutol
embA 4245198 c.1966_1968delCTCinsGG frameshift_variant&missense_variant 0.17 ethambutol Uncertain significance
embA 4245206 c.1974A>C synonymous_variant 0.16 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.16 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.17 ethambutol
embA 4245222 p.Tyr664His missense_variant 0.15 ethambutol Uncertain significance
embB 4247395 c.882C>G synonymous_variant 0.15 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.15 ethambutol
embB 4247428 c.915C>T synonymous_variant 0.22 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.23 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4247446 c.933C>T synonymous_variant 0.24 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.24 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.23 ethambutol
embB 4247485 c.972C>T synonymous_variant 0.26 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.25 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.27 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.29 ethambutol
embB 4247544 p.Ser344Thr missense_variant 0.26 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.26 ethambutol
embB 4247566 c.1053C>G synonymous_variant 0.19 ethambutol
embB 4247567 c.1054C>T synonymous_variant 0.19 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.21 ethambutol
embB 4247579 p.Ala356Ile missense_variant 0.2 ethambutol
embB 4247588 c.1075_1077delCTAinsAC frameshift_variant&missense_variant 0.19 ethambutol
embB 4247608 c.1095G>T synonymous_variant 0.17 ethambutol
embB 4247621 c.1108C>T synonymous_variant 0.18 ethambutol
embB 4248001 c.1488C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248007 c.1494C>G synonymous_variant 0.16 ethambutol
embB 4248008 c.1495C>T synonymous_variant 0.16 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.15 ethambutol Uncertain significance
embB 4248044 p.Lys511Ser missense_variant 0.15 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.17 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.16 ethambutol
embB 4248118 c.1605T>A synonymous_variant 0.22 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.21 ethambutol
embB 4248139 c.1626C>G synonymous_variant 0.21 ethambutol
embB 4248149 c.1636_1638delACCinsGG frameshift_variant&missense_variant 0.19 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248160 c.1647C>T synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248169 c.1656C>A synonymous_variant 0.19 ethambutol
embB 4248172 c.1659G>C synonymous_variant 0.18 ethambutol
embB 4248175 c.1662G>C synonymous_variant 0.17 ethambutol
embB 4248178 c.1665C>T synonymous_variant 0.17 ethambutol
embB 4248181 c.1668C>T synonymous_variant 0.17 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.18 ethambutol
embB 4248214 c.1701C>A synonymous_variant 0.19 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4248226 c.1713G>C synonymous_variant 0.21 ethambutol
embB 4249408 c.2895G>A synonymous_variant 1.0 ethambutol Not assoc w R
aftB 4268186 c.651C>G synonymous_variant 0.16 ethambutol
aftB 4268194 p.Leu215Val missense_variant 0.15 ethambutol
ubiA 4269143 p.Leu231Met missense_variant 0.14 ethambutol
aftB 4269164 c.-328T>C upstream_gene_variant 0.16 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407798 c.405G>T synonymous_variant 1.0 streptomycin Not assoc w R