TB-Profiler result

Run: SRR13423544
Summary

Run ID: SRR13423544

Sample name:

Date: 2024-04-15T19:49:22.836418

Number of reads: 3432378

Percentage reads mapped: 85.58

Median coverage: 79.0

Strain: lineage4.5

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.5 Euro-American RD122 0.96
lineage4 Euro-American None 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.2 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.19 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.16 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance Mutation from literature
embB 4247448 p.His312Arg missense_variant 0.2 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 636 c.636C>G synonymous_variant 0.15 isoniazid
dnaA 645 c.645A>G synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 1317 c.1317A>G synonymous_variant 0.15 isoniazid
gyrB 6209 c.970C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6217 c.978G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrB 6223 c.984G>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6242 p.Arg335Ser missense_variant 0.14 levofloxacin
moxifloxacin
gyrB 6250 c.1011A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6253 c.1014G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 6299 c.1060C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6325 c.-977C>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6760 c.-542G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 6778 c.-524C>T upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrB 6793 c.1554T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6797 p.Gly520Thr missense_variant 0.21 levofloxacin
moxifloxacin
gyrB 6824 c.1585C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6841 c.1602T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6859 c.1620T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6862 c.1623C>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7694 c.393A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7892 c.591G>A synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8054 c.753T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8057 c.756A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8069 c.768T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8219 c.918T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8225 c.924T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8235 c.934_936delTTAinsCG frameshift_variant&missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8283 c.982_984delATCinsCG frameshift_variant&missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8288 c.987T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8342 c.1041G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8351 c.1050C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8366 c.1065G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8480 c.1179C>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8516 c.1215T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8537 c.1236G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8546 c.1245T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8556 p.Ala419Gln missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8561 c.1260A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8562 c.1261C>T synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8786 c.1485T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8852 c.1551T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8858 c.1557T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 8867 c.1566A>G synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8870 c.1569G>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.34 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.35 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>G synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8939 c.1638T>C synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCC frameshift_variant&missense_variant 0.3 levofloxacin
moxifloxacin
gyrA 8951 c.1650G>A synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8966 c.1665C>G synonymous_variant 0.36 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Arg missense_variant 0.36 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.3 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9023 c.1722A>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9029 c.1728T>C synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9605 c.2304C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9611 p.Asp770Glu missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9626 c.2325T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9635 c.2334T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9644 c.2343T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9647 c.2346C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9650 c.2349G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9666 p.Arg789Gly missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9674 c.2373T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9677 c.2376C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9704 c.2403T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
fgd1 490833 c.51G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 490851 c.69A>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 490902 c.120T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 491091 c.309T>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fgd1 491094 c.312C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491106 c.324T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fgd1 491121 c.339A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Asp missense_variant 0.14 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fgd1 491191 p.Gly137Arg missense_variant 0.22 clofazimine
pretomanid
delamanid
fgd1 491196 c.414A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491202 c.420G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491203 p.Gln141Glu missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491212 p.Ser144Arg missense_variant 0.23 clofazimine
pretomanid
delamanid
fgd1 491217 c.435T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491232 c.450T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491241 p.Asp153Glu missense_variant 0.27 clofazimine
pretomanid
delamanid
fgd1 491244 c.462T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 491259 c.477T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 491286 c.504G>C synonymous_variant 0.29 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491292 c.510G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fgd1 491295 c.513C>G synonymous_variant 0.26 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 491296 p.Val172Ile missense_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 491319 c.537G>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fgd1 491331 c.549G>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
mshA 575623 c.276C>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575629 c.282A>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575635 c.288A>C synonymous_variant 0.2 ethionamide
isoniazid Not assoc w R - Interim
mshA 575638 c.291T>C synonymous_variant 0.2 ethionamide
isoniazid
mshA 575641 c.294A>G synonymous_variant 0.2 ethionamide
isoniazid
mshA 575648 p.Val101Gln missense_variant 0.17 ethionamide
isoniazid
mshA 575658 p.Ala104Val missense_variant 0.19 ethionamide
isoniazid
mshA 575665 c.318G>C synonymous_variant 0.19 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575669 p.Leu108Val missense_variant 0.19 ethionamide
isoniazid
mshA 575689 c.342G>C synonymous_variant 0.3 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.28 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.28 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.33 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.34 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.33 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.33 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.32 ethionamide
isoniazid
mshA 575767 c.420G>A synonymous_variant 0.25 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.25 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.27 ethionamide
isoniazid
mshA 575821 c.474G>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575824 c.477T>G synonymous_variant 0.22 ethionamide
isoniazid
ccsA 620029 c.139C>T synonymous_variant 0.98 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620295 c.405G>C synonymous_variant 0.14 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620317 c.427_429delGTCinsCG frameshift_variant&missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620322 c.432G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620340 c.450C>G synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620349 c.459A>G synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620362 p.Ala158Thr missense_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.33 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAC frameshift_variant&missense_variant 0.32 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.29 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620730 c.840C>T synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.27 capreomycin
amikacin
kanamycin
ccsA 620745 c.855G>C synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620778 c.888T>C synonymous_variant 0.22 capreomycin
amikacin
kanamycin
ccsA 620784 c.894C>G synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620787 c.897C>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620809 c.919C>T synonymous_variant 0.15 capreomycin
amikacin
kanamycin
Rv0565c 657220 p.Ala84Val missense_variant 0.14 ethionamide
Rv0565c 657222 c.249C>G synonymous_variant 0.16 ethionamide
Rv0565c 657231 c.238_240delATCinsGG frameshift_variant&missense_variant 0.17 ethionamide Uncertain significance
Rv0565c 657237 c.234A>G synonymous_variant 0.17 ethionamide
Rv0565c 657242 p.Glu77Lys missense_variant 0.17 ethionamide
Rv0565c 657259 p.Tyr71Phe missense_variant 0.18 ethionamide
Rv0565c 657261 c.210C>G synonymous_variant 0.18 ethionamide
Rv0565c 657264 c.207T>C synonymous_variant 0.17 ethionamide
Rv0565c 657267 c.204G>C synonymous_variant 0.17 ethionamide
hadA 732321 p.Glu131Ala missense_variant 0.22 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.21 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.2 isoniazid
hadA 732346 c.417T>C synonymous_variant 0.29 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.24 isoniazid
hadA 732389 p.Ser154Thr missense_variant 0.24 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.23 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.22 isoniazid
nusG 734421 c.168A>G synonymous_variant 0.22 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.2 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.23 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.24 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.21 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.22 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.25 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.27 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734595 c.342C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734596 c.343T>C synonymous_variant 0.27 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.25 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.22 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.26 rifampicin
nusG 734703 c.450T>C synonymous_variant 0.16 rifampicin
rpoB 759644 c.-163T>A upstream_gene_variant 0.14 rifampicin
rpoB 759647 c.-160T>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoB 760106 c.300G>T synonymous_variant 0.17 rifampicin
rpoB 760112 c.306T>C synonymous_variant 0.17 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.2 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.22 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.16 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760328 c.522G>C synonymous_variant 0.25 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.25 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.29 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.31 rifampicin
rpoB 760361 c.555T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760376 p.Asp190Glu missense_variant 0.42 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.47 rifampicin
rpoB 760418 c.612G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.33 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.25 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.25 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.22 rifampicin
rpoB 760634 c.828T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.2 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760718 c.912C>G synonymous_variant 0.24 rifampicin
rpoB 760721 c.915C>G synonymous_variant 0.23 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760751 c.945G>C synonymous_variant 0.19 rifampicin
rpoB 760757 c.951T>C synonymous_variant 0.19 rifampicin
rpoB 760759 p.Val318Ala missense_variant 0.2 rifampicin
rpoB 760763 c.957C>T synonymous_variant 0.2 rifampicin
rpoB 760769 c.963C>G synonymous_variant 0.2 rifampicin
rpoB 760775 c.969G>C synonymous_variant 0.2 rifampicin
rpoB 760776 c.970_972delTCGinsAGC synonymous_variant 0.21 rifampicin
rpoB 760793 c.987A>G synonymous_variant 0.2 rifampicin
rpoB 760805 c.999G>C synonymous_variant 0.22 rifampicin
rpoB 760817 c.1011A>G synonymous_variant 0.17 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.17 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.17 rifampicin
rpoB 760869 p.Val355Ile missense_variant 0.17 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.19 rifampicin
rpoB 760919 c.1113C>G synonymous_variant 0.21 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.2 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.21 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760970 c.1164G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.31 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.24 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>A synonymous_variant 0.2 rifampicin
rpoB 761057 c.1251G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.2 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.19 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>G synonymous_variant 0.16 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.23 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761297 c.1491C>T synonymous_variant 0.26 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761360 c.1554T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.16 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761492 c.1686G>C synonymous_variant 0.19 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.21 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.22 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.28 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.26 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.28 rifampicin
rpoB 761690 c.1884G>C synonymous_variant 0.29 rifampicin
rpoB 761723 c.1917_1919delAGAinsG frameshift_variant&synonymous_variant 0.24 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.22 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.23 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.23 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.26 rifampicin
rpoB 761768 c.1962G>T synonymous_variant 0.25 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.25 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.27 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.31 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.3 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.3 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.24 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.21 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>G synonymous_variant 0.2 rifampicin
rpoB 761882 c.2076C>G synonymous_variant 0.21 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.21 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.21 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.18 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.18 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.18 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.18 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.18 rifampicin
rpoB 761924 c.2118G>A synonymous_variant 0.18 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.16 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.16 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.16 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.17 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 762380 c.-990T>G upstream_gene_variant 0.15 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.15 rifampicin
rpoC 763486 c.117T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.21 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTG frameshift_variant&missense_variant 0.22 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.24 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.27 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.27 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.26 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.24 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.18 rifampicin
rpoC 763768 c.399C>G synonymous_variant 0.18 rifampicin
rpoC 763819 c.450G>C synonymous_variant 0.19 rifampicin
rpoC 763831 c.462A>G synonymous_variant 0.22 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.21 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.23 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.23 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.22 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.22 rifampicin
rpoC 763885 c.516C>G synonymous_variant 0.21 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.22 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.22 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.22 rifampicin
rpoC 763945 c.576T>C synonymous_variant 0.24 rifampicin
rpoC 763960 c.591T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763967 p.Gly200Ser missense_variant 0.19 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.17 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.19 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.2 rifampicin
rpoC 764040 p.Ser224Asn missense_variant 0.22 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.26 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.27 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.3 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764110 c.741C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.34 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.32 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.31 rifampicin
rpoC 764203 c.834G>T synonymous_variant 0.3 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.27 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.23 rifampicin
rpoC 764269 c.900G>C synonymous_variant 0.27 rifampicin
rpoC 764282 c.913_915delTCGinsAGC synonymous_variant 0.2 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.15 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.15 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.16 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.2 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764695 c.1326T>C synonymous_variant 0.17 rifampicin
rpoC 764716 c.1347G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764812 c.1443C>G synonymous_variant 0.2 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.37 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764878 c.1509C>G synonymous_variant 0.3 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.29 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.27 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.19 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765052 c.1683C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765287 c.1918C>T synonymous_variant 0.23 rifampicin
rpoC 765292 c.1923G>T synonymous_variant 0.24 rifampicin
rpoC 765298 c.1929G>C synonymous_variant 0.23 rifampicin
rpoC 765300 p.Val644Ala missense_variant 0.23 rifampicin Uncertain significance
rpoC 765319 c.1950A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765326 p.His653Ala missense_variant 0.19 rifampicin Uncertain significance
rpoC 765330 p.Ser654Asn missense_variant 0.19 rifampicin Uncertain significance
rpoC 765383 p.Met672Leu missense_variant 0.2 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.22 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.22 rifampicin
rpoC 765412 c.2043T>C synonymous_variant 0.21 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>G synonymous_variant 0.24 rifampicin
rpoC 765452 c.2083_2085delGCCinsTG frameshift_variant&missense_variant 0.25 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 765517 c.2148C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.28 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.25 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.26 rifampicin
rpoC 765578 c.2209C>T synonymous_variant 0.24 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.23 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.18 rifampicin
rpoC 765658 c.2289C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.28 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.29 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.33 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.32 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.3 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.23 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.21 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765970 c.2601C>T synonymous_variant 0.16 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766010 p.Ser881Thr missense_variant 0.15 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.15 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.17 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.16 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.17 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.16 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.18 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.22 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.2 rifampicin
rpoC 766588 c.3219G>A synonymous_variant 0.2 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.22 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.23 rifampicin
rpoC 766607 c.3238_3240delATCinsCG frameshift_variant&missense_variant 0.29 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.27 rifampicin
rpoC 766645 c.3276A>G synonymous_variant 0.3 rifampicin
rpoC 766651 c.3282T>C synonymous_variant 0.33 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.32 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.38 rifampicin
rpoC 766693 c.3324C>T synonymous_variant 0.28 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.28 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.32 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.29 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.36 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.37 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.34 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.32 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.3 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.27 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>G synonymous_variant 0.16 rifampicin
rpoC 767158 c.3789T>G synonymous_variant 0.23 rifampicin
rpoC 767167 c.3798C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.27 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775916 c.2565T>G synonymous_variant 0.19 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781631 c.72G>C synonymous_variant 0.18 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.21 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.21 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.24 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.25 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.25 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.21 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.23 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.23 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.22 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.27 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.27 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.33 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.27 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.27 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.26 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.29 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.3 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.32 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.27 streptomycin Uncertain significance
rplC 800546 c.-263T>C upstream_gene_variant 0.19 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.18 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.23 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.23 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.22 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.26 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.22 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.2 linezolid
rplC 800738 c.-71T>C upstream_gene_variant 0.22 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.22 linezolid
rplC 800794 c.-15_-9delAGATTGGinsGAGTT upstream_gene_variant 0.19 linezolid
rplC 800814 c.6A>G synonymous_variant 0.18 linezolid
rplC 800817 c.9A>T synonymous_variant 0.18 linezolid
rplC 800844 c.36T>C synonymous_variant 0.24 linezolid
rplC 800865 c.57A>G synonymous_variant 0.22 linezolid
rplC 800867 p.Ser20Asn missense_variant 0.2 linezolid
rplC 800874 c.66A>G synonymous_variant 0.22 linezolid
rplC 800877 c.69A>C synonymous_variant 0.22 linezolid
rplC 800880 c.72A>G synonymous_variant 0.22 linezolid
rplC 800889 c.81C>G synonymous_variant 0.24 linezolid
rplC 800907 c.99C>G synonymous_variant 0.24 linezolid
rplC 800916 c.108A>G synonymous_variant 0.27 linezolid
rplC 800937 c.129A>G synonymous_variant 0.26 linezolid
rplC 800939 p.Arg44Gln missense_variant 0.25 linezolid
rplC 800946 c.138T>C synonymous_variant 0.25 linezolid
rplC 800949 c.141T>C synonymous_variant 0.24 linezolid
rplC 800955 c.147C>G synonymous_variant 0.25 linezolid
rplC 800967 c.159C>G synonymous_variant 0.2 linezolid
rplC 800970 c.162T>C synonymous_variant 0.18 linezolid Not assoc w R - Interim
rplC 800982 c.174C>T synonymous_variant 0.16 linezolid
rplC 800985 c.177A>G synonymous_variant 0.16 linezolid
rplC 800994 c.186C>G synonymous_variant 0.15 linezolid
rplC 801004 p.Leu66Val missense_variant 0.15 linezolid
rplC 801009 c.201A>C synonymous_variant 0.15 linezolid
rplC 801012 c.204T>C synonymous_variant 0.14 linezolid
rplC 801171 c.363A>G synonymous_variant 0.18 linezolid
rplC 801174 c.366T>C synonymous_variant 0.21 linezolid
rplC 801222 c.414T>C synonymous_variant 0.17 linezolid
rplC 801228 c.420T>C synonymous_variant 0.17 linezolid
rplC 801246 c.438C>G synonymous_variant 0.14 linezolid
Rv1129c 1254056 p.Asp160Ala missense_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
fbiC 1303509 c.579G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303512 c.582T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303560 c.630G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303584 c.654C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303605 c.675C>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303608 c.678G>A synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303614 c.684C>T synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303617 c.687C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303632 c.702T>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303674 c.744C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303701 c.771C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303708 c.778T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303716 c.786C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303728 c.798G>A synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303731 c.801A>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303732 p.Ser268Ala missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303737 c.807G>A synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303746 c.816T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303749 c.819G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303881 c.951G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303981 p.Val351Ile missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304520 c.1590A>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304523 c.1593G>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304526 c.1596T>A synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304544 c.1614T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304545 p.Val539Thr missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304574 c.1644C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304628 c.1698G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.21 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304754 c.1824G>A synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304790 c.1860C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>G synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>G synonymous_variant 0.16 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304925 c.1995G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304934 c.2004C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1304940 c.2010A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1305393 c.2463T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
Rv1258c 1407380 c.-40C>T upstream_gene_variant 0.98 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide
embR 1416467 p.Asp294Ala missense_variant 0.96 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.34 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.34 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.23 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473937 n.280C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473945 n.288T>C non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1473981 n.324delGinsTT non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.35 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.32 capreomycin
linezolid
rrl 1474051 n.394T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474056 n.399T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474104 n.447G>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474112 n.455T>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474356 n.699T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474376 n.719T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475271 n.1614A>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475273 n.1616T>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.45 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.34 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.36 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.23 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476105 n.2448_2449delGAinsT non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.27 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.22 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476755 n.3098G>A non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
inhA 1673574 c.-628C>G upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1673580 c.-622T>C upstream_gene_variant 0.16 ethionamide
isoniazid Uncertain significance
inhA 1673589 c.-613A>G upstream_gene_variant 0.16 ethionamide
isoniazid
inhA 1673595 c.-607A>C upstream_gene_variant 0.15 ethionamide
isoniazid
fabG1 1673596 c.157_159delAAGinsGC frameshift_variant&missense_variant 0.15 ethionamide
isoniazid
inhA 1673607 c.-595T>C upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1673610 c.-592C>T upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1673616 c.-586A>G upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1673619 c.-583T>C upstream_gene_variant 0.17 ethionamide
isoniazid
fabG1 1673633 p.Ser65Asn missense_variant 0.15 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.3 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.29 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.26 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.23 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.24 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674636 c.435C>G synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674654 c.453G>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674693 c.492C>G synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674718 c.517A>C synonymous_variant 0.17 ethionamide
isoniazid
rpsA 1833568 c.27G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.24 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.29 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.28 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.32 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.28 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.25 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.26 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.26 pyrazinamide
rpsA 1833790 c.249T>A synonymous_variant 0.24 pyrazinamide
rpsA 1833799 c.258C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833811 c.270G>C synonymous_variant 0.24 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.14 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.17 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.18 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.17 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834297 c.756C>G synonymous_variant 0.16 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.18 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>A synonymous_variant 0.16 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834474 c.933C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.18 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834594 c.1053C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834726 c.1185C>A synonymous_variant 0.16 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.16 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.15 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.16 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.22 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.21 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
ndh 2101906 c.1137G>C synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2101915 c.1128T>C synonymous_variant 0.17 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101918 c.1123_1125delAGGinsCC frameshift_variant&missense_variant 0.17 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2101924 c.1119T>G synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2101939 c.1104A>C synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2101960 c.1083A>G synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101966 c.1077T>G synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2101978 c.1063_1065delAACinsGT frameshift_variant&missense_variant 0.21 ethionamide Uncertain significance
delamanid Uncertain significance
isoniazid Uncertain significance
ndh 2101988 p.Ala352Gly missense_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2102009 p.Ser345Asn missense_variant 0.27 ethionamide
delamanid
isoniazid
ndh 2102020 c.1023A>G synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102023 c.1020G>C synonymous_variant 0.24 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102026 c.1017G>C synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2102050 c.993T>C synonymous_variant 0.15 ethionamide
delamanid
isoniazid
katG 2155632 c.480A>C synonymous_variant 0.21 isoniazid
katG 2155637 p.Leu159Ile missense_variant 0.24 isoniazid
katG 2155641 p.Lys157Asn missense_variant 0.24 isoniazid Uncertain significance
katG 2155677 c.435C>G synonymous_variant 0.2 isoniazid
katG 2155680 c.432G>C synonymous_variant 0.21 isoniazid
katG 2155691 c.421T>C synonymous_variant 0.23 isoniazid
katG 2155695 p.Ala139Val missense_variant 0.23 isoniazid
katG 2155704 c.408C>G synonymous_variant 0.24 isoniazid
katG 2155716 c.396T>C synonymous_variant 0.22 isoniazid
katG 2155722 c.390G>C synonymous_variant 0.24 isoniazid
katG 2155740 p.Gly124Gln missense_variant 0.2 isoniazid
katG 2155747 p.Ala122Gly missense_variant 0.22 isoniazid
PPE35 2170568 p.Ile15Met missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2517947 c.-168C>T upstream_gene_variant 0.26 isoniazid
kasA 2517974 c.-141T>C upstream_gene_variant 0.23 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.21 isoniazid
kasA 2517992 c.-123C>G upstream_gene_variant 0.19 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.17 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.16 isoniazid
kasA 2518540 c.426T>G synonymous_variant 0.15 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.16 isoniazid
kasA 2518792 c.678C>G synonymous_variant 0.17 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.16 isoniazid
kasA 2518816 c.702C>A synonymous_variant 0.15 isoniazid
kasA 2518822 c.708C>G synonymous_variant 0.17 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.18 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.16 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.17 isoniazid
kasA 2519167 c.1053T>C synonymous_variant 0.19 isoniazid
ahpC 2726591 c.399C>G synonymous_variant 0.19 isoniazid
ahpC 2726593 p.Val134Ala missense_variant 0.19 isoniazid
ahpC 2726600 c.408T>C synonymous_variant 0.19 isoniazid
ahpC 2726612 c.420C>G synonymous_variant 0.18 isoniazid
ahpC 2726638 p.Ala149Val missense_variant 0.19 isoniazid
ahpC 2726645 c.453C>G synonymous_variant 0.19 isoniazid
ahpC 2726657 c.465A>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
ahpC 2726669 p.Asp159Glu missense_variant 0.17 isoniazid
ahpC 2726672 c.480G>A synonymous_variant 0.16 isoniazid Not assoc w R - Interim
ahpC 2726681 c.489A>G synonymous_variant 0.16 isoniazid
Rv2477c 2782537 c.1506T>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782540 c.1503T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782549 c.1494T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2782558 c.1485T>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782561 c.1482G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782567 c.1476C>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782576 c.1467C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782582 c.1461C>T synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782587 p.Leu486Val missense_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782591 c.1452T>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782948 c.1095A>G synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782969 c.1074A>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783013 c.1030T>C synonymous_variant 0.33 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783015 p.Ser343Thr missense_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783020 c.1023G>C synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783040 p.Ala335Thr missense_variant 0.32 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783059 c.984T>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783062 c.981C>G synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.34 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.34 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>T synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783243 p.Thr267Ser missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783287 c.756C>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783290 c.753G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783293 p.Glu250Asp missense_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783320 c.723C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783332 c.711T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783362 c.681G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783365 c.678C>T synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783373 p.Glu224Gln missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783416 c.625_627delATCinsGG frameshift_variant&missense_variant 0.19 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783461 c.582T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783467 c.576G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783494 c.549C>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783551 c.492G>A synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783569 c.474C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783578 p.Glu155Asp missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783629 c.414C>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783641 c.402G>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783773 c.270A>G synonymous_variant 0.22 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783794 c.249G>A synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 p.Asp61Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2752c 3065273 p.Thr307Ala missense_variant 0.98 ethambutol Uncertain significance
moxifloxacin
levofloxacin
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3065457 c.735A>T synonymous_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065463 c.729T>C synonymous_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067316 c.630A>G synonymous_variant 0.14 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067724 c.222G>A synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.21 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.21 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067787 c.159G>A synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073863 c.609T>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3073872 c.598_600delATCinsGG frameshift_variant&missense_variant 0.19 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.27 para-aminosalicylic_acid
thyA 3073953 c.519T>C synonymous_variant 0.29 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.24 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074057 p.Glu139Gln missense_variant 0.15 para-aminosalicylic_acid
thyA 3074061 c.411A>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074076 c.396C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074082 c.390G>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074100 c.372T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074106 c.366T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074160 c.312A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074163 c.307_309delGCTinsAG frameshift_variant&missense_variant 0.18 para-aminosalicylic_acid
thyA 3074172 c.300G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074175 c.297A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074181 c.291A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074184 c.288A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3074187 c.285T>C synonymous_variant 0.22 para-aminosalicylic_acid
thyA 3074199 c.273G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.18 para-aminosalicylic_acid
thyA 3074214 c.258T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074217 c.255T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3074235 c.237C>T synonymous_variant 0.22 para-aminosalicylic_acid
fbiD 3339480 p.Gln121His missense_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
lpqB 3624389 c.522C>G synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624401 c.510C>T synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624407 c.504C>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624428 c.483A>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624452 c.459T>C synonymous_variant 0.23 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625543 c.-633G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.27 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3625592 p.Ser341Asn missense_variant 0.3 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.3 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.33 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.3 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625627 c.-717C>T upstream_gene_variant 0.26 bedaquiline
rifampicin
lpqB 3625648 c.-738T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3625656 c.958T>C synonymous_variant 0.2 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625735 c.879C>A synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625750 c.864G>A synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.14 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626759 c.591T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.28 bedaquiline
rifampicin
mtrB 3626780 c.-167T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.42 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.45 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.45 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.47 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.46 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrA 3626912 c.438T>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626930 c.-317A>G upstream_gene_variant 0.4 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.42 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>G upstream_gene_variant 0.43 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.38 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627167 c.-554T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627170 c.-557C>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
fbiB 3642602 c.1068A>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiB 3642605 c.1071A>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiB 3642614 c.1080C>T synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiB 3642620 c.1086T>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiB 3642656 c.1122G>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
rpoA 3877542 c.966C>T synonymous_variant 0.21 rifampicin
rpoA 3877553 p.Glu319Gln missense_variant 0.2 rifampicin
rpoA 3877557 c.951C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.3 rifampicin
rpoA 3877638 c.870T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.25 rifampicin
rpoA 3877677 p.Ala277Ser missense_variant 0.18 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877818 c.690A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.21 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.22 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.17 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.18 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.2 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.33 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.4 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.4 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.38 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.37 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.37 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.37 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.37 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.38 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.36 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.33 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.31 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.28 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.29 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.24 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.27 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.25 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.29 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.31 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.28 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.26 rifampicin
rpoA 3878202 c.306G>C synonymous_variant 0.25 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.28 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.28 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.22 rifampicin
rpoA 3878575 c.-68C>T upstream_gene_variant 1.0 rifampicin Not assoc w R
rpoA 3878764 c.-257A>G upstream_gene_variant 0.18 rifampicin
rpoA 3878781 c.-274A>G upstream_gene_variant 0.18 rifampicin
rpoA 3878782 c.-275G>C upstream_gene_variant 0.17 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.17 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.18 rifampicin
rpoA 3878806 c.-299C>G upstream_gene_variant 0.17 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.16 rifampicin
rpoA 3878826 c.-319A>T upstream_gene_variant 0.16 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.15 rifampicin
rpoA 3878838 c.-331A>C upstream_gene_variant 0.15 rifampicin
rpoA 3878839 c.-332C>G upstream_gene_variant 0.15 rifampicin
rpoA 3878842 c.-335G>C upstream_gene_variant 0.15 rifampicin
rpoA 3878845 c.-338G>T upstream_gene_variant 0.15 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.2 rifampicin
rpoA 3878875 c.-368C>T upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878878 c.-371T>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878884 c.-377C>G upstream_gene_variant 0.19 rifampicin
rpoA 3878889 c.-382A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878894 c.-387A>G upstream_gene_variant 0.18 rifampicin
ddn 3986648 c.-196C>G upstream_gene_variant 0.22 delamanid
pretomanid
ddn 3986655 c.-189A>T upstream_gene_variant 0.21 delamanid
pretomanid
ddn 3986660 c.-184C>T upstream_gene_variant 0.2 delamanid
pretomanid
ddn 3986665 c.-179G>C upstream_gene_variant 0.17 delamanid
pretomanid
ddn 3986667 c.-177_-176delCTinsAC upstream_gene_variant 0.17 delamanid
pretomanid
ddn 3986681 c.-163C>G upstream_gene_variant 0.16 delamanid
pretomanid
clpC1 4038347 c.2358G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.25 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.33 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038452 c.2253G>C synonymous_variant 0.35 pyrazinamide
clpC1 4038461 p.Ala748Asp missense_variant 0.33 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.35 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.32 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.35 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.35 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.3 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4038740 c.1965G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.3 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.3 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.3 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.27 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.24 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039127 c.1578G>A synonymous_variant 0.22 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.17 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039388 c.1317C>A synonymous_variant 0.28 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.27 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.25 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>G synonymous_variant 0.33 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039517 c.1188C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.3 pyrazinamide
clpC1 4039526 c.1179G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039532 c.1173C>T synonymous_variant 0.33 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.36 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039576 p.Ala377Ser missense_variant 0.41 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.41 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.4 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.32 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.25 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.25 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.28 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040153 c.552A>G synonymous_variant 0.28 pyrazinamide
clpC1 4040162 c.543G>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040168 c.537G>C synonymous_variant 0.28 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.28 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040264 c.441C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040267 c.438A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.22 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.24 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.28 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.28 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.27 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.31 pyrazinamide
clpC1 4040444 c.261C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040450 c.255A>G synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4040459 c.246C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.25 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>A synonymous_variant 0.23 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
glpK 4138463 c.1293C>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138472 c.1284G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138478 c.1278T>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138481 c.1275G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138511 c.1245C>T synonymous_variant 0.14 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138538 c.1218C>T synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138541 c.1215C>T synonymous_variant 0.15 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138547 c.1209C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138568 c.1188A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138571 c.1185C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138583 c.1173G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138586 c.1170C>T synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139204 c.552G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139207 c.547_549delAATinsCG frameshift_variant&missense_variant 0.15 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4240183 c.321A>G synonymous_variant 0.15 ethambutol
embC 4240204 c.342T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4240210 c.348C>G synonymous_variant 0.18 ethambutol
embC 4240216 c.354T>C synonymous_variant 0.17 ethambutol
embC 4240229 c.367_369delCTGinsAC frameshift_variant&missense_variant 0.15 ethambutol
embC 4240232 p.Gln124Val missense_variant 0.15 ethambutol
embC 4240258 c.396T>G synonymous_variant 0.15 ethambutol
embC 4240514 p.Val218Met missense_variant 0.15 ethambutol
embC 4240582 c.720C>G synonymous_variant 0.15 ethambutol
embC 4240591 c.729C>G synonymous_variant 0.16 ethambutol
embC 4240594 c.732C>G synonymous_variant 0.15 ethambutol
embC 4240600 c.738G>C synonymous_variant 0.16 ethambutol
embC 4240642 c.780G>C synonymous_variant 0.23 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.22 ethambutol
embC 4240654 c.792C>T synonymous_variant 0.24 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.24 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.29 ethambutol Not assoc w R
embC 4240678 c.816T>G synonymous_variant 0.24 ethambutol
embC 4240685 c.823_825delACCinsGG frameshift_variant&missense_variant 0.23 ethambutol
embC 4240693 c.831T>C synonymous_variant 0.24 ethambutol
embC 4240706 p.Val282Thr missense_variant 0.26 ethambutol
embC 4240726 c.864G>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embC 4240789 c.927T>C synonymous_variant 0.17 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.18 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.14 ethambutol
embC 4240919 c.1057_1059delCTCinsTG frameshift_variant&missense_variant 0.19 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.17 ethambutol
embC 4240945 c.1083T>C synonymous_variant 0.18 ethambutol
embC 4240951 c.1089C>G synonymous_variant 0.15 ethambutol
embC 4240980 p.Thr373Lys missense_variant 0.14 ethambutol
embC 4240983 p.Ser374Asn missense_variant 0.15 ethambutol
embC 4240990 c.1128A>G synonymous_variant 0.15 ethambutol
embC 4240996 c.1134G>C synonymous_variant 0.17 ethambutol
embC 4241017 c.1155T>C synonymous_variant 0.18 ethambutol
embC 4241023 c.1161T>G synonymous_variant 0.17 ethambutol
embC 4241026 c.1164C>G synonymous_variant 0.16 ethambutol
embC 4241035 c.1173G>A synonymous_variant 0.19 ethambutol
embC 4241050 c.1188T>G synonymous_variant 0.15 ethambutol
embC 4241104 c.1242G>A synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.31 ethambutol
embC 4241137 c.1275G>C synonymous_variant 0.3 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.28 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 0.26 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.25 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.14 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.93 ethambutol Not assoc w R
embA 4243482 p.Ala84Ser missense_variant 1.0 ethambutol Uncertain significance
embA 4245137 c.1905T>C synonymous_variant 0.21 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.2 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.18 ethambutol
embB 4245620 c.-894T>C upstream_gene_variant 0.16 ethambutol
embB 4245626 c.-888G>C upstream_gene_variant 0.17 ethambutol
embB 4247365 c.852A>C synonymous_variant 0.15 ethambutol
embB 4247371 c.858C>G synonymous_variant 0.15 ethambutol
embB 4247375 p.Leu288Val missense_variant 0.15 ethambutol
embB 4247386 c.873T>C synonymous_variant 0.19 ethambutol
embB 4247389 c.876C>G synonymous_variant 0.2 ethambutol
embB 4247395 c.882C>G synonymous_variant 0.18 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.18 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.2 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.23 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.23 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.2 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.18 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.15 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.14 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.14 ethambutol
embB 4247806 c.1293G>C synonymous_variant 0.15 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.16 ethambutol
embB 4247824 c.1311C>G synonymous_variant 0.17 ethambutol
embB 4247830 c.1317A>C synonymous_variant 0.18 ethambutol
embB 4247836 c.1323A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4247842 c.1329T>C synonymous_variant 0.17 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.19 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.18 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.14 ethambutol Not assoc w R - Interim
embB 4247890 c.1377C>T synonymous_variant 0.14 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.16 ethambutol
embB 4248095 c.1582_1584delCTCinsTG frameshift_variant&missense_variant 0.18 ethambutol
embB 4248118 c.1605T>C synonymous_variant 0.21 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.24 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.24 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.26 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.26 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4248206 c.1693_1695delAGCinsGG frameshift_variant&missense_variant 0.28 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.28 ethambutol
embB 4248265 c.1752C>T synonymous_variant 0.23 ethambutol
embB 4248266 c.1753C>T synonymous_variant 0.23 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.21 ethambutol
embB 4248298 c.1785C>T synonymous_variant 0.14 ethambutol
embB 4249369 c.2856T>C synonymous_variant 0.15 ethambutol
embB 4249381 c.2868A>G synonymous_variant 0.18 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.18 ethambutol
embB 4249420 c.2907G>C synonymous_variant 0.18 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.19 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.19 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.2 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.24 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.22 ethambutol
embB 4249456 c.2943G>C synonymous_variant 0.28 ethambutol
embB 4249469 p.Leu986Met missense_variant 0.27 ethambutol
embB 4249483 c.2970C>G synonymous_variant 0.27 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.27 ethambutol
embB 4249487 c.2974T>C synonymous_variant 0.27 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.29 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.19 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4249528 c.3015C>G synonymous_variant 0.16 ethambutol
embB 4249529 p.Ile1006Val missense_variant 0.16 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.16 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.17 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.17 ethambutol
ubiA 4269104 p.Ser244Gly missense_variant 0.24 ethambutol
ubiA 4269117 p.Glu239Asp missense_variant 0.25 ethambutol
aftB 4269123 c.-287T>C upstream_gene_variant 0.24 ethambutol
ubiA 4269141 c.691_693delTTGinsGC frameshift_variant&missense_variant 0.3 ethambutol
ubiA 4269144 c.690C>G synonymous_variant 0.28 ethambutol Not assoc w R - Interim
ubiA 4269149 p.Val229Leu missense_variant 0.29 ethambutol Uncertain significance
aftB 4269183 c.-347T>C upstream_gene_variant 0.3 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin