TB-Profiler result

Run: SRR1180270
Summary

Run ID: SRR1180270

Sample name:

Date: 2025-02-11T20:27:06.628644

Number of reads: 3072924

Percentage reads mapped: 68.01

Median coverage: 67.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.8.1 M.bovis None 0.06
lineage2 East-Asian RD105 0.97
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.98
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
p.Ala356Val Uncertain significance Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
embB 4247448 p.His312Arg missense_variant 0.33 ethambutol Mutation from literature
embB 4247580 p.Ala356Val missense_variant 0.17 ethambutol Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1092 c.1092T>C synonymous_variant 0.27 isoniazid Not assoc w R - Interim
dnaA 1098 c.1098A>G synonymous_variant 0.17 isoniazid
dnaA 1104 c.1104T>C synonymous_variant 0.23 isoniazid
dnaA 1110 c.1110T>C synonymous_variant 0.22 isoniazid
dnaA 1122 c.1122C>A synonymous_variant 0.15 isoniazid Not assoc w R - Interim
dnaA 1197 c.1197T>G synonymous_variant 0.16 isoniazid
dnaA 1245 c.1245G>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 1254 c.1254T>C synonymous_variant 0.32 isoniazid
dnaA 1278 c.1278T>C synonymous_variant 0.29 isoniazid
dnaA 1287 c.1287A>G synonymous_variant 0.23 isoniazid
dnaA 1291 c.1291_1293delCTTinsTTA synonymous_variant 0.22 isoniazid
dnaA 1299 c.1299G>T synonymous_variant 0.21 isoniazid
dnaA 1317 c.1317A>C synonymous_variant 0.19 isoniazid
dnaA 1323 c.1323C>T synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 1338 c.1338T>C synonymous_variant 0.16 isoniazid
dnaA 1413 c.1413A>C synonymous_variant 0.16 isoniazid
dnaA 1441 c.1441C>T synonymous_variant 0.2 isoniazid
dnaA 1449 c.1449G>A synonymous_variant 0.2 isoniazid
dnaA 1473 c.1473T>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
gyrB 6145 c.906C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 6331 c.-971A>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7030 c.-272C>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7033 c.-269G>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrB 7060 c.1821T>C synonymous_variant 0.29 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7066 c.-236G>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7081 c.-221T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7090 c.-212C>T upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrB 7093 c.1854T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7099 c.-203G>A upstream_gene_variant 0.26 levofloxacin
moxifloxacin
gyrA 7108 c.-194G>A upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7120 c.-182T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7123 c.-179C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7129 c.-173T>G upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>C upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7147 c.-155G>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 7151 c.1912C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 7165 c.-137C>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7784 c.483A>G synonymous_variant 0.26 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7838 c.537C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8078 c.777A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8090 c.789C>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8099 c.798T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8121 c.820T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8207 c.906T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8225 p.Asp308Glu missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 8237 c.936A>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8247 p.Ile316Val missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8315 c.1014G>A synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8318 c.1017C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8324 c.1023T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 8339 c.1038A>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.23 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8375 c.1074G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8393 c.1092T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8421 p.Val374Met missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8450 c.1149G>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8453 c.1152A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8462 c.1161A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8471 c.1170T>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 8486 c.1185T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8510 c.1209G>A synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8516 c.1215T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8519 c.1218A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8531 c.1230G>A synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8546 c.1245T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8561 c.1260A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8571 c.1270C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8603 c.1302A>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8609 c.1308G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8619 c.1318T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8627 c.1326C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8645 c.1344C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8655 p.Ile452Val missense_variant 0.22 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8723 c.1422G>A synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8729 c.1428T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8767 p.Arg489Lys missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8783 c.1482G>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8786 c.1485T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8813 c.1512C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8933 c.1632G>A synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8942 c.1641G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCTC synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9029 c.1728T>G synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9101 c.1800A>G synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9119 c.1818A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9128 c.1827C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 0.16 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9147 p.Gly616Ser missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 9153 p.Thr618Asp missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9185 c.1884C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9192 c.1891C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9197 c.1896G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9203 c.1902G>A synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9242 c.1941A>C synonymous_variant 0.29 levofloxacin
moxifloxacin
gyrA 9248 c.1947G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9251 c.1950G>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9284 c.1983T>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9626 c.2325T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9629 c.2328C>A synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9630 p.Val777Ile missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 9635 c.2334T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
fgd1 490797 c.15G>A synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 490803 c.21T>A synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fgd1 490818 c.36C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 490830 c.48A>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fgd1 490863 c.81C>A synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 490998 c.216T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491007 c.225G>C synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fgd1 491013 c.231C>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fgd1 491064 c.282A>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fgd1 491286 c.504G>C synonymous_variant 0.17 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491295 c.513C>G synonymous_variant 0.19 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fgd1 491742 c.960T>C synonymous_variant 1.0 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575590 c.243T>G synonymous_variant 0.19 isoniazid
ethionamide
mshA 575635 c.288A>G synonymous_variant 0.18 isoniazid
ethionamide
mshA 575652 p.Arg102Gln missense_variant 0.21 isoniazid
ethionamide
mshA 575659 c.312A>G synonymous_variant 0.2 isoniazid
ethionamide
mshA 575662 c.315C>A synonymous_variant 0.17 isoniazid
ethionamide
mshA 575665 c.318G>C synonymous_variant 0.21 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575686 c.339G>A synonymous_variant 0.21 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.23 isoniazid
ethionamide
mshA 575692 c.345G>A synonymous_variant 0.2 isoniazid
ethionamide
mshA 575713 c.366G>A synonymous_variant 0.19 isoniazid
ethionamide
mshA 575734 c.387T>G synonymous_variant 0.25 isoniazid
ethionamide
mshA 575746 c.399C>G synonymous_variant 0.26 isoniazid
ethionamide
mshA 575772 p.Val142Ala missense_variant 0.17 isoniazid
ethionamide
mshA 575785 c.438T>C synonymous_variant 0.19 isoniazid
ethionamide
mshA 575821 c.474G>C synonymous_variant 0.26 isoniazid
ethionamide
mshA 575824 c.477T>C synonymous_variant 0.19 isoniazid
ethionamide
mshA 575842 c.495G>C synonymous_variant 0.2 isoniazid
ethionamide
mshA 575848 c.501C>T synonymous_variant 0.19 isoniazid
ethionamide
mshA 575872 c.525C>T synonymous_variant 0.2 isoniazid
ethionamide
mshA 575878 c.531A>T synonymous_variant 0.22 isoniazid
ethionamide
mshA 575884 c.537G>C synonymous_variant 0.35 isoniazid
ethionamide
mshA 575893 c.546C>G synonymous_variant 0.32 isoniazid
ethionamide
mshA 575905 c.558G>C synonymous_variant 0.24 isoniazid
ethionamide
mshA 575907 p.Ala187Val missense_variant 0.68 isoniazid Not assoc w R
ethionamide Not assoc w R
mshA 575916 p.Asp190Ala missense_variant 0.29 isoniazid
ethionamide
mshA 575924 p.Gly193Ile missense_variant 0.26 isoniazid
ethionamide
ccsA 620256 c.366C>G synonymous_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620340 c.450C>G synonymous_variant 0.22 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.21 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620625 p.Ile245Met missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
ccsA 620766 c.876C>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
ccsA 620773 p.Ile295Val missense_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620783 p.Ala298Val missense_variant 0.2 kanamycin
capreomycin
amikacin
ccsA 620787 c.897C>G synonymous_variant 0.18 kanamycin
capreomycin
amikacin
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
hadA 731710 c.-220A>T upstream_gene_variant 0.16 isoniazid
hadA 731738 c.-192G>T upstream_gene_variant 0.2 isoniazid
hadA 731753 c.-177A>G upstream_gene_variant 0.23 isoniazid
hadA 731774 c.-156T>C upstream_gene_variant 0.35 isoniazid
hadA 731795 c.-135C>T upstream_gene_variant 0.22 isoniazid
hadA 731816 c.-114G>C upstream_gene_variant 0.19 isoniazid
hadA 731843 c.-87T>C upstream_gene_variant 0.2 isoniazid
hadA 732361 c.432C>T synonymous_variant 0.19 isoniazid
hadA 732376 c.447T>C synonymous_variant 0.18 isoniazid
nusG 734376 c.123G>A synonymous_variant 0.17 rifampicin
nusG 734407 p.Val52Ile missense_variant 0.27 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.33 rifampicin
nusG 734424 c.171G>T synonymous_variant 0.27 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.2 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>T synonymous_variant 0.22 rifampicin
nusG 734505 c.252G>A synonymous_variant 0.18 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.33 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.27 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.25 rifampicin
nusG 734616 c.363C>A synonymous_variant 0.22 rifampicin
nusG 734625 c.372T>C synonymous_variant 0.18 rifampicin
nusG 734631 c.378G>A synonymous_variant 0.17 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.16 rifampicin
nusG 734757 c.504T>C synonymous_variant 0.15 rifampicin
nusG 734781 c.528A>G synonymous_variant 0.17 rifampicin
nusG 734826 c.573A>C synonymous_variant 0.25 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.32 rifampicin
nusG 734865 c.612G>C synonymous_variant 0.17 rifampicin
nusG 734874 c.621G>A synonymous_variant 0.17 rifampicin
nusG 734880 c.627C>T synonymous_variant 0.19 rifampicin
nusG 734895 c.642A>G synonymous_variant 0.25 rifampicin
nusG 734913 c.660C>G synonymous_variant 0.21 rifampicin
mmaA3 737277 c.873G>C synonymous_variant 0.17 isoniazid
mmaA3 737280 c.870G>A synonymous_variant 0.17 isoniazid
mmaA3 737307 p.Met281Ile missense_variant 0.23 isoniazid
mmaA3 737310 c.840A>G synonymous_variant 0.23 isoniazid
mmaA3 737316 c.834G>A synonymous_variant 0.28 isoniazid
mmaA3 737340 c.810A>G synonymous_variant 0.32 isoniazid
mmaA3 737349 c.801G>C synonymous_variant 0.23 isoniazid
mmaA3 737358 c.792A>C synonymous_variant 0.25 isoniazid
mmaA3 737364 p.Ala262Glu missense_variant 0.19 isoniazid
mmaA3 737373 c.777C>A synonymous_variant 0.18 isoniazid
rpoB 759635 c.-172C>T upstream_gene_variant 0.24 rifampicin
rpoB 759644 c.-163T>A upstream_gene_variant 0.25 rifampicin
rpoB 759647 c.-160T>C upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoB 759661 c.-146G>C upstream_gene_variant 0.22 rifampicin
rpoB 759670 c.-137C>T upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoB 759671 c.-136G>T upstream_gene_variant 0.18 rifampicin
rpoB 759675 c.-132T>C upstream_gene_variant 0.18 rifampicin
rpoB 759676 c.-131A>G upstream_gene_variant 0.18 rifampicin
rpoB 760101 c.295T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.27 rifampicin
rpoB 760118 c.312T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.21 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.18 rifampicin
rpoB 760145 c.339C>G synonymous_variant 0.19 rifampicin
rpoB 760184 c.378A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760244 c.438G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760274 c.468G>A synonymous_variant 0.18 rifampicin
rpoB 760298 c.492G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.32 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.3 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760403 c.597C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760415 c.609C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760424 c.618C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760478 c.672C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>T synonymous_variant 0.17 rifampicin
rpoB 760484 c.678A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.16 rifampicin Uncertain significance
rpoB 760534 p.Val243Asp missense_variant 0.17 rifampicin
rpoB 760547 c.741G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.24 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.24 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.31 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760724 c.918T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760817 c.1011A>G synonymous_variant 0.2 rifampicin
rpoB 760830 c.1024T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Ala missense_variant 0.21 rifampicin
rpoB 760859 c.1053T>G synonymous_variant 0.19 rifampicin
rpoB 760868 c.1062C>G synonymous_variant 0.19 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760994 c.1188G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>T synonymous_variant 0.16 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.21 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.21 rifampicin
rpoB 761133 c.1327_1329delTTGinsCTC synonymous_variant 0.21 rifampicin
rpoB 761150 c.1344A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.23 rifampicin
rpoB 761207 c.1401C>T synonymous_variant 0.23 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>G synonymous_variant 0.17 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761354 c.1548C>T synonymous_variant 0.24 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761367 p.Glu521Gln missense_variant 0.2 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.2 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.25 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.27 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.26 rifampicin
rpoB 761438 c.1632G>C synonymous_variant 0.16 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.22 rifampicin
rpoB 761483 c.1677G>C synonymous_variant 0.24 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.24 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761561 c.1755C>G synonymous_variant 0.24 rifampicin
rpoB 761564 c.1758G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761600 c.1794T>G synonymous_variant 0.16 rifampicin
rpoB 761603 c.1797C>T synonymous_variant 0.16 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.3 rifampicin
rpoB 761612 c.1806G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.27 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761867 c.2061C>A synonymous_variant 0.2 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.25 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.21 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.19 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.18 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.18 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>G synonymous_variant 0.15 rifampicin
rpoB 762011 c.2205G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762017 c.2211A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.3 rifampicin Uncertain significance
rpoB 762119 c.2313C>T synonymous_variant 0.17 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.17 rifampicin
rpoB 762134 c.2328C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.21 rifampicin
rpoB 762224 c.2418C>G synonymous_variant 0.19 rifampicin
rpoB 762236 c.2430G>A synonymous_variant 0.2 rifampicin
rpoB 762254 c.2448T>C synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.21 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.19 rifampicin
rpoB 762269 c.2463G>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762278 c.2472C>G synonymous_variant 0.21 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762347 c.2541T>C synonymous_variant 0.17 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.16 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.19 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.19 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.18 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762857 c.3051C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>A upstream_gene_variant 0.19 rifampicin
rpoB 762989 c.3183G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763050 c.-320C>T upstream_gene_variant 0.17 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>T upstream_gene_variant 0.17 rifampicin
rpoC 763082 c.-288C>G upstream_gene_variant 0.17 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.18 rifampicin
rpoC 763202 c.-168A>G upstream_gene_variant 0.17 rifampicin
rpoC 763206 c.-164_-163delAGinsTC upstream_gene_variant 0.17 rifampicin
rpoC 763408 c.39T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.23 rifampicin
rpoC 763430 c.61A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763435 c.66A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>A synonymous_variant 0.18 rifampicin
rpoC 763573 c.204G>T synonymous_variant 0.15 rifampicin
rpoC 763600 c.231C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763606 c.237C>T synonymous_variant 0.19 rifampicin
rpoC 763618 c.249C>A synonymous_variant 0.23 rifampicin
rpoC 763636 c.267T>G synonymous_variant 0.28 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763732 c.363C>G synonymous_variant 0.23 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.2 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.25 rifampicin
rpoC 763781 p.Ser138Ala missense_variant 0.26 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.18 rifampicin
rpoC 763836 p.Ala156Val missense_variant 0.26 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.19 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.18 rifampicin
rpoC 763888 c.519G>T synonymous_variant 0.16 rifampicin
rpoC 763987 c.618C>T synonymous_variant 0.18 rifampicin
rpoC 763991 p.Ile208Leu missense_variant 0.28 rifampicin
rpoC 763996 c.627T>C synonymous_variant 0.27 rifampicin
rpoC 764005 c.636G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764011 c.642T>C synonymous_variant 0.16 rifampicin
rpoC 764024 c.655T>C synonymous_variant 0.24 rifampicin
rpoC 764059 c.690G>C synonymous_variant 0.16 rifampicin
rpoC 764083 c.714A>G synonymous_variant 0.24 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.17 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764317 c.948C>G synonymous_variant 0.18 rifampicin
rpoC 764353 c.984G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764387 c.1018T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764500 c.1131C>G synonymous_variant 0.2 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.21 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.22 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.23 rifampicin
rpoC 764575 c.1206T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.18 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764681 c.1312C>T synonymous_variant 0.16 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.19 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764833 c.1464A>G synonymous_variant 0.22 rifampicin
rpoC 764872 c.1503A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519_1521delTTGinsCTC synonymous_variant 0.17 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.16 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765409 c.2040T>C synonymous_variant 0.17 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.23 rifampicin
rpoC 765547 c.2178C>A synonymous_variant 0.3 rifampicin
rpoC 765556 c.2187G>C synonymous_variant 0.29 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.28 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.24 rifampicin
rpoC 765592 c.2223C>T synonymous_variant 0.16 rifampicin
rpoC 765622 p.Glu751Asp missense_variant 0.19 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765784 c.2415C>G synonymous_variant 0.24 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.24 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.24 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.25 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.24 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.26 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765934 c.2565C>T synonymous_variant 0.16 rifampicin
rpoC 765952 c.2583G>C synonymous_variant 0.3 rifampicin
rpoC 765967 c.2598C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765997 c.2628T>C synonymous_variant 0.17 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.17 rifampicin
rpoC 766105 c.2736C>T synonymous_variant 0.19 rifampicin
rpoC 766315 c.2946C>G synonymous_variant 0.18 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.27 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.27 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 766417 c.3048C>T synonymous_variant 0.16 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.27 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.19 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.28 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.19 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766530 p.Arg1054Gln missense_variant 0.19 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.23 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.22 rifampicin
rpoC 766585 c.3216T>C synonymous_variant 0.21 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.19 rifampicin
rpoC 766672 c.3303T>C synonymous_variant 0.22 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.25 rifampicin
rpoC 766747 c.3378C>T synonymous_variant 0.17 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.31 rifampicin
rpoC 766792 c.3423C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 766795 c.3426C>T synonymous_variant 0.18 rifampicin
rpoC 766801 c.3432C>T synonymous_variant 0.2 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.22 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.2 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.19 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.18 rifampicin
rpoC 766903 c.3534C>T synonymous_variant 0.21 rifampicin
rpoC 766907 c.3538C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766918 c.3549C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.19 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.22 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.35 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767167 c.3798C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.24 rifampicin
rpoC 767185 c.3816G>T synonymous_variant 0.24 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767200 c.3831G>A synonymous_variant 0.27 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776182 p.Asp767Asn missense_variant 1.0 bedaquiline Not assoc w R
clofazimine Not assoc w R
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 bedaquiline
clofazimine
rpsL 781395 c.-165T>C upstream_gene_variant 0.98 streptomycin Not assoc w R
rpsL 781628 c.69T>C synonymous_variant 0.18 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.19 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.19 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.2 streptomycin
rpsL 781718 c.159C>G synonymous_variant 0.19 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.22 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.26 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.19 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.19 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.18 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.18 streptomycin
rpsL 781886 c.327C>T synonymous_variant 0.16 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.21 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.25 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.23 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.26 streptomycin Uncertain significance
rplC 800567 c.-242A>G upstream_gene_variant 0.29 linezolid
rplC 800579 c.-230C>T upstream_gene_variant 0.28 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.26 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.18 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.2 linezolid
rplC 800648 c.-161A>C upstream_gene_variant 0.21 linezolid
rplC 800693 c.-116A>C upstream_gene_variant 0.24 linezolid
rplC 800714 c.-95C>T upstream_gene_variant 0.21 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.21 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.22 linezolid
rplC 800759 c.-50C>T upstream_gene_variant 0.19 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.23 linezolid
rplC 800783 c.-26C>T upstream_gene_variant 0.23 linezolid
rplC 800797 c.-12T>G upstream_gene_variant 0.17 linezolid
rplC 800800 c.-9G>T upstream_gene_variant 0.16 linezolid
rplC 800801 c.-8A>G upstream_gene_variant 0.17 linezolid
rplC 800817 c.9A>C synonymous_variant 0.2 linezolid
rplC 800844 c.36T>C synonymous_variant 0.2 linezolid
rplC 801147 c.339T>C synonymous_variant 0.2 linezolid
rplC 801153 c.345G>C synonymous_variant 0.23 linezolid
rplC 801174 c.366T>C synonymous_variant 0.25 linezolid
rplC 801210 c.402T>C synonymous_variant 0.22 linezolid
rplC 801312 c.504G>C synonymous_variant 0.28 linezolid
rplC 801339 c.531T>G synonymous_variant 0.27 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.25 linezolid
rplC 801348 c.540T>G synonymous_variant 0.25 linezolid
rplC 801357 c.549T>C synonymous_variant 0.27 linezolid
rplC 801372 c.564G>A synonymous_variant 0.2 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.98 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1303545 c.615A>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1303590 c.660A>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303605 c.675C>G synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1303632 c.702T>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1303695 c.765T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303708 c.778T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1303731 c.801A>G synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1303737 c.807G>A synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1303752 c.822A>G synonymous_variant 0.2 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304565 c.1635C>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304598 c.1668C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304625 c.1695C>T synonymous_variant 0.31 pretomanid
delamanid
clofazimine
fbiC 1304628 c.1698G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304658 c.1728C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304661 c.1731C>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304691 c.1761G>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304757 c.1827A>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>G synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>C synonymous_variant 0.28 pretomanid
delamanid
clofazimine
fbiC 1304796 c.1866G>A synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304799 c.1869G>C synonymous_variant 0.3 pretomanid
delamanid
clofazimine
fbiC 1304811 c.1881C>G synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fbiC 1304817 c.1887T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304823 c.1893C>T synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.3 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.29 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304893 p.Gly655Ser missense_variant 0.26 pretomanid
delamanid
clofazimine
fbiC 1304896 c.1966C>T synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304915 p.Asp662Gly missense_variant 0.24 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.19 pretomanid
delamanid
clofazimine
fbiC 1304940 c.2010A>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304946 c.2016G>C synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.22 pretomanid
delamanid
clofazimine
fbiC 1304994 c.2064A>G synonymous_variant 0.17 pretomanid
delamanid
clofazimine
fbiC 1305150 c.2220C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1305186 c.2256C>T synonymous_variant 0.19 pretomanid
delamanid
clofazimine
sigE 1364889 c.477A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
sigE 1364898 c.486C>T synonymous_variant 0.18 pyrazinamide
sigE 1364913 c.501C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
sigE 1364919 c.507T>C synonymous_variant 0.27 pyrazinamide
sigE 1364922 p.Glu170Asp missense_variant 0.19 pyrazinamide
sigE 1364955 c.543G>C synonymous_variant 0.18 pyrazinamide
sigE 1364964 c.552T>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
sigE 1364980 c.568T>C synonymous_variant 0.21 pyrazinamide
sigE 1364984 p.Ala191Asp missense_variant 0.21 pyrazinamide
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
pyrazinamide Uncertain significance
isoniazid Uncertain significance
atpE 1461161 c.117C>T synonymous_variant 0.16 bedaquiline
atpE 1461167 c.123G>T synonymous_variant 0.16 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.18 bedaquiline
atpE 1461185 c.141G>A synonymous_variant 0.16 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.16 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.17 bedaquiline
atpE 1461224 c.180T>C synonymous_variant 0.16 bedaquiline
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472030 n.185_189delGGGATinsTTGGC non_coding_transcript_exon_variant 0.22 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472040 n.195T>C non_coding_transcript_exon_variant 0.34 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.34 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.36 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.39 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.3 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.18 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.29 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.28 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.19 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473417 n.-241C>T upstream_gene_variant 0.19 capreomycin
linezolid
rrl 1473421 n.-237G>A upstream_gene_variant 0.21 capreomycin
linezolid
rrl 1473437 n.-221T>C upstream_gene_variant 0.22 capreomycin
linezolid
rrl 1473449 n.-209G>A upstream_gene_variant 0.2 capreomycin
linezolid
rrl 1473648 n.-9_-7delTTG upstream_gene_variant 0.17 capreomycin
linezolid
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473888 n.231T>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1474083 n.426C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475273 n.1616T>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475289 n.1632G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475290 n.1633A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.34 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476035 n.2378G>A non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476089 n.2432T>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1476095 n.2438C>G non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476117 n.2460G>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1476580 n.2923G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.33 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476679 n.3022T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476726 n.3069A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476732 n.3075T>C non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1476755 n.3098G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
inhA 1673505 c.-697A>T upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1673535 c.-667A>G upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673547 c.-655T>C upstream_gene_variant 0.24 isoniazid
ethionamide
inhA 1673568 c.-634C>G upstream_gene_variant 0.23 isoniazid
ethionamide
inhA 1673574 c.-628C>G upstream_gene_variant 0.25 isoniazid
ethionamide
inhA 1673589 c.-613A>C upstream_gene_variant 0.21 isoniazid
ethionamide
inhA 1673595 c.-607A>C upstream_gene_variant 0.19 isoniazid
ethionamide
inhA 1673596 c.-606A>G upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673712 c.-490A>C upstream_gene_variant 0.17 isoniazid Uncertain significance
ethionamide
inhA 1673748 c.-454A>G upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673749 c.-453_-452delAAinsCG upstream_gene_variant 0.18 isoniazid
ethionamide
inhA 1673955 c.-247G>C upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1674015 c.-187C>A upstream_gene_variant 0.15 isoniazid
ethionamide
inhA 1674018 c.-184G>C upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1674024 c.-178T>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1674033 c.-169T>C upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1674037 c.-165C>G upstream_gene_variant 0.17 isoniazid
ethionamide
inhA 1674060 c.-142A>G upstream_gene_variant 0.16 isoniazid
ethionamide
inhA 1674703 c.502T>C synonymous_variant 0.24 isoniazid
ethionamide
inhA 1674718 c.517A>C synonymous_variant 0.25 isoniazid
ethionamide
inhA 1674729 c.528G>C synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674756 c.555T>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
ethionamide Not assoc w R - Interim
inhA 1674762 c.561T>C synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674774 c.573A>C synonymous_variant 0.26 isoniazid
ethionamide
inhA 1674777 c.576C>G synonymous_variant 0.28 isoniazid
ethionamide
inhA 1674780 c.579T>G synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674819 c.618G>T synonymous_variant 0.15 isoniazid
ethionamide
inhA 1674840 c.639C>T synonymous_variant 0.22 isoniazid Not assoc w R - Interim
ethionamide
inhA 1674846 p.Ile215Met missense_variant 0.23 isoniazid
ethionamide
inhA 1674870 c.669T>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674903 c.702T>C synonymous_variant 0.27 isoniazid
ethionamide
inhA 1674904 p.Ala235Pro missense_variant 0.26 isoniazid
ethionamide
rpsA 1833256 c.-286C>G upstream_gene_variant 0.17 pyrazinamide
rpsA 1833262 c.-280T>A upstream_gene_variant 0.16 pyrazinamide
rpsA 1833589 c.48A>T synonymous_variant 0.24 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.16 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.23 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.23 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.29 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.35 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.34 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.35 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.35 pyrazinamide
rpsA 1833892 c.351G>A synonymous_variant 0.18 pyrazinamide
rpsA 1833904 c.363G>A synonymous_variant 0.17 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.34 pyrazinamide
rpsA 1833934 c.393C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1833949 c.408T>C synonymous_variant 0.35 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.21 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.35 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.34 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.31 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834213 c.672G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.27 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.3 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.33 pyrazinamide
rpsA 1834495 c.954G>A synonymous_variant 0.3 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.37 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.36 pyrazinamide
rpsA 1834615 c.1074C>T synonymous_variant 0.33 pyrazinamide
rpsA 1834618 c.1077G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.31 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.31 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.2 pyrazinamide
tsnR 1853370 c.-236_-234delGCAinsTCG upstream_gene_variant 0.18 linezolid
tsnR 1853574 c.-32T>C upstream_gene_variant 1.0 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1917975 c.36C>G synonymous_variant 0.16 capreomycin
bacA 2063550 c.1179C>G synonymous_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064264 c.465C>G synonymous_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064269 c.460A>C synonymous_variant 0.15 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064296 c.433T>C synonymous_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064297 c.432C>T synonymous_variant 0.16 kanamycin
capreomycin
streptomycin
amikacin
bacA 2064312 c.417C>G synonymous_variant 0.17 kanamycin
capreomycin
streptomycin
amikacin
ndh 2101980 p.Asn355Asp missense_variant 0.17 isoniazid
delamanid
ethionamide
ndh 2101990 c.1053G>C synonymous_variant 0.17 isoniazid
delamanid
ethionamide
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517941 c.-174C>G upstream_gene_variant 0.24 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.16 isoniazid
kasA 2518187 p.Ile25Val missense_variant 0.19 isoniazid
kasA 2518248 p.Ala45Val missense_variant 0.19 isoniazid
kasA 2518252 c.138C>T synonymous_variant 0.18 isoniazid
kasA 2518279 c.165T>C synonymous_variant 0.17 isoniazid
kasA 2518283 p.Ala57Pro missense_variant 0.18 isoniazid
kasA 2518297 c.183C>T synonymous_variant 0.16 isoniazid
kasA 2518300 c.186T>C synonymous_variant 0.15 isoniazid
kasA 2518591 c.477G>C synonymous_variant 0.16 isoniazid
kasA 2518618 c.504G>C synonymous_variant 0.17 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.22 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.22 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.22 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.2 isoniazid
kasA 2518789 c.675G>T synonymous_variant 0.16 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.16 isoniazid
kasA 2518816 c.702C>T synonymous_variant 0.18 isoniazid
kasA 2518822 c.708C>T synonymous_variant 0.17 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.24 isoniazid
kasA 2518855 c.741C>G synonymous_variant 0.16 isoniazid
kasA 2518856 p.Ile248Leu missense_variant 0.16 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.21 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.2 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.18 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.18 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.18 isoniazid
ahpC 2726348 c.156T>C synonymous_variant 0.21 isoniazid
ahpC 2726354 c.162G>C synonymous_variant 0.2 isoniazid
ahpC 2726357 c.165A>G synonymous_variant 0.18 isoniazid Not assoc w R - Interim
ahpC 2726366 c.174G>C synonymous_variant 0.18 isoniazid
ahpC 2726378 c.186T>G synonymous_variant 0.17 isoniazid
Rv2477c 2783158 c.885A>C synonymous_variant 0.24 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783194 c.849A>G synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783215 c.828G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783289 p.Leu252Ile missense_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783299 c.744A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783302 c.741A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783329 c.714G>A synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783356 c.687C>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783395 c.648T>C synonymous_variant 0.38 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783410 c.633G>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783422 c.621T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783428 c.615C>T synonymous_variant 0.27 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol
amikacin Not assoc w R - Interim
Rv2477c 2783461 c.582T>C synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783473 c.570A>G synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783499 c.544T>C synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783502 c.541T>C synonymous_variant 0.21 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783512 c.531A>G synonymous_variant 0.23 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783548 c.495T>A synonymous_variant 0.17 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.19 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783566 c.477C>T synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783572 c.471A>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783611 c.432C>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.18 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783650 c.393C>T synonymous_variant 0.18 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783659 c.384A>G synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783857 c.186C>G synonymous_variant 0.15 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.36 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783926 c.117C>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783935 c.108C>G synonymous_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783950 c.93C>T synonymous_variant 0.2 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783953 c.90G>C synonymous_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783956 c.87T>C synonymous_variant 0.33 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783971 c.72G>C synonymous_variant 0.32 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.28 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2784414 c.-372A>G upstream_gene_variant 0.19 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784429 c.-387A>G upstream_gene_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784454 c.-412G>A upstream_gene_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.21 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2784492 c.-450C>G upstream_gene_variant 0.16 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
pepQ 2859468 c.951G>T synonymous_variant 0.19 bedaquiline
clofazimine
pepQ 2859489 p.Val310Ala missense_variant 0.19 bedaquiline
clofazimine
Rv2681 2996930 c.192C>T synonymous_variant 0.16 capreomycin
Rv2681 2996940 p.Gly68Asn missense_variant 0.25 capreomycin
Rv2681 2996945 c.207C>G synonymous_variant 0.27 capreomycin
Rv2681 2996951 c.213C>T synonymous_variant 0.18 capreomycin
Rv2681 2996957 c.219T>C synonymous_variant 0.29 capreomycin
Rv2681 2996966 c.228G>T synonymous_variant 0.16 capreomycin
Rv2681 2996974 p.Glu79Gly missense_variant 0.23 capreomycin
Rv2681 2996987 c.249A>G synonymous_variant 0.17 capreomycin
Rv2681 2997092 c.354T>C synonymous_variant 0.18 capreomycin
Rv2681 2997098 c.360C>G synonymous_variant 0.2 capreomycin
Rv2681 2997104 c.366C>G synonymous_variant 0.18 capreomycin
Rv2681 2997116 c.378T>C synonymous_variant 0.17 capreomycin
Rv2681 2997122 c.384A>G synonymous_variant 0.16 capreomycin Not assoc w R - Interim
Rv2752c 3065947 p.Gly82Ala missense_variant 0.16 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.26 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.25 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066618 c.-427A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066633 c.-442T>C upstream_gene_variant 0.21 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066644 c.-453T>C upstream_gene_variant 0.23 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
Rv2752c 3066707 c.-516A>G upstream_gene_variant 0.15 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067316 c.630A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067394 c.552G>T synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067886 c.60A>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.24 para-aminosalicylic_acid
thyA 3073932 c.540C>T synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073956 c.516G>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073968 c.504C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.37 para-aminosalicylic_acid
thyA 3073983 c.489C>T synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.36 para-aminosalicylic_acid
thyA 3073997 c.475C>T synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.3 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.28 para-aminosalicylic_acid
thyA 3074053 p.Arg140Gln missense_variant 0.21 para-aminosalicylic_acid
thyA 3074056 p.Glu139Pro missense_variant 0.2 para-aminosalicylic_acid
thyA 3074130 c.342G>C synonymous_variant 0.16 para-aminosalicylic_acid
thyA 3074133 c.339C>T synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074157 c.315C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3074199 c.273G>A synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074205 p.Glu89Asp missense_variant 0.16 para-aminosalicylic_acid
thyA 3074217 c.255T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074252 p.Glu74Gln missense_variant 0.17 para-aminosalicylic_acid
thyA 3074256 c.216G>A synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074268 c.204T>C synonymous_variant 0.19 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 0.92 pyrazinamide Not assoc w R - Interim
lpqB 3623443 p.Ser490Thr missense_variant 0.18 rifampicin
bedaquiline
lpqB 3623444 c.1467T>C synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3623468 c.1443T>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3623471 c.1440C>T synonymous_variant 0.23 rifampicin
bedaquiline
lpqB 3623489 c.1422C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3623492 c.1419T>C synonymous_variant 0.19 rifampicin
bedaquiline
lpqB 3624686 p.Glu75Gln missense_variant 0.21 rifampicin
bedaquiline
lpqB 3624701 c.210T>A synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624713 c.198C>T synonymous_variant 0.21 rifampicin
bedaquiline
lpqB 3624722 c.189C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.16 rifampicin
bedaquiline
lpqB 3624749 c.162G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625095 p.Glu507Gln missense_variant 0.21 rifampicin
bedaquiline
lpqB 3625117 c.-207T>G upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625123 c.-213T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
lpqB 3625141 c.-231T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625243 c.-333T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625255 c.-345T>G upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625279 c.-369C>G upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3625301 p.Ala438Gly missense_variant 0.17 rifampicin
bedaquiline
lpqB 3625537 c.-627T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625543 c.-633G>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3625569 c.1045T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625594 c.-684T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625612 c.-702G>T upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625630 c.-720C>G upstream_gene_variant 0.17 rifampicin
bedaquiline
lpqB 3625648 c.-738T>C upstream_gene_variant 0.18 rifampicin
bedaquiline
lpqB 3625663 c.-753G>C upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625684 c.-774G>A upstream_gene_variant 0.19 rifampicin
bedaquiline
lpqB 3625690 c.-780T>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625747 c.-837G>T upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.27 rifampicin Uncertain significance
bedaquiline
lpqB 3625762 c.-852A>C upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626562 p.Pro18Ser missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3626726 c.-113T>C upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3626776 c.-163A>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626780 c.-167T>C upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626798 c.-185T>A upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626819 c.-206G>A upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626852 c.-239G>A upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626890 c.-277T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>C upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626954 c.-341C>G upstream_gene_variant 0.18 rifampicin
bedaquiline
mtrB 3626972 c.-359A>G upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3626987 c.-374C>G upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627008 c.-395G>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627011 c.-398T>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3627071 c.-458G>C upstream_gene_variant 0.23 rifampicin
bedaquiline
mtrB 3627083 c.-470G>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrA 3627098 c.252A>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>G upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3627182 c.-569T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627203 c.-590C>G upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.22 rifampicin
bedaquiline
mtrB 3627272 c.-659G>T upstream_gene_variant 0.2 rifampicin
bedaquiline
mtrB 3627287 c.-674C>G upstream_gene_variant 0.19 rifampicin
bedaquiline
mtrB 3627301 c.-688T>C upstream_gene_variant 0.16 rifampicin
bedaquiline
fbiA 3640269 c.-274A>C upstream_gene_variant 0.16 pretomanid
delamanid
clofazimine
fbiA 3640282 c.-261C>G upstream_gene_variant 0.2 pretomanid
delamanid
clofazimine
fbiA 3640298 c.-245A>G upstream_gene_variant 0.18 pretomanid
delamanid
clofazimine
fbiA 3640318 c.-225A>T upstream_gene_variant 0.17 pretomanid
delamanid
clofazimine
rpoA 3877557 c.951C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877587 c.921A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.19 rifampicin
rpoA 3877764 c.744C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.18 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.16 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.21 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.24 rifampicin
rpoA 3878025 c.483C>T synonymous_variant 0.22 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.22 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.24 rifampicin
rpoA 3878043 c.465G>C synonymous_variant 0.19 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.16 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.23 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.24 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.21 rifampicin
rpoA 3878157 c.351C>G synonymous_variant 0.31 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878172 c.336G>C synonymous_variant 0.21 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>C synonymous_variant 0.21 rifampicin
rpoA 3878211 c.297G>A synonymous_variant 0.21 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878256 c.252G>C synonymous_variant 0.38 rifampicin
rpoA 3878262 c.246C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.33 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878295 c.213A>G synonymous_variant 0.33 rifampicin
rpoA 3878298 c.210A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3878364 c.144A>T synonymous_variant 0.2 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878406 c.102G>T synonymous_variant 0.31 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.2 rifampicin
rpoA 3878713 c.-206G>C upstream_gene_variant 0.17 rifampicin
rpoA 3878719 c.-212G>A upstream_gene_variant 0.17 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878728 c.-221G>A upstream_gene_variant 0.21 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.27 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.29 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.24 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878791 c.-284C>T upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.19 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.24 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.28 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.24 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.27 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.21 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878998 c.-491C>G upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3879006 c.-499A>C upstream_gene_variant 0.23 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879022 c.-515G>C upstream_gene_variant 0.27 rifampicin
rpoA 3879033 c.-526C>T upstream_gene_variant 0.15 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.17 rifampicin
rpoA 3879061 c.-554C>T upstream_gene_variant 0.16 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.15 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.29 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.3 rifampicin
rpoA 3879100 c.-593G>A upstream_gene_variant 0.16 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.34 rifampicin
rpoA 3879148 c.-641G>C upstream_gene_variant 0.23 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.33 rifampicin
rpoA 3879172 c.-665C>T upstream_gene_variant 0.24 rifampicin
rpoA 3879184 c.-677G>A upstream_gene_variant 0.23 rifampicin
rpoA 3879202 c.-695T>C upstream_gene_variant 0.22 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.27 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.25 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.25 rifampicin
ddn 3986636 c.-208C>A upstream_gene_variant 0.16 pretomanid
delamanid
ddn 3986648 c.-196C>G upstream_gene_variant 0.17 pretomanid
delamanid
ddn 3987020 c.177G>A synonymous_variant 0.16 pretomanid
delamanid
ddn 3987035 c.192C>G synonymous_variant 0.18 pretomanid
delamanid
clpC1 4038271 p.Pro812Ala missense_variant 0.25 pyrazinamide
clpC1 4038272 c.2433T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038308 c.2397G>C synonymous_variant 0.19 pyrazinamide
clpC1 4038344 c.2361G>A synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038350 c.2355C>G synonymous_variant 0.28 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.27 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.26 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4038436 p.Ala757Ser missense_variant 0.21 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.19 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.25 pyrazinamide
clpC1 4038519 p.Arg729Gln missense_variant 0.2 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.2 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.26 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.22 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4038800 c.1905C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.31 pyrazinamide
clpC1 4038838 c.1867C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038839 c.1866G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4038890 c.1815G>A synonymous_variant 0.24 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.36 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.36 pyrazinamide
clpC1 4038917 c.1788C>T synonymous_variant 0.18 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTTG synonymous_variant 0.38 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.4 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.42 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.37 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4038980 c.1725C>T synonymous_variant 0.36 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.32 pyrazinamide
clpC1 4038995 c.1710G>A synonymous_variant 0.22 pyrazinamide
clpC1 4039009 c.1696C>T synonymous_variant 0.23 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.36 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.25 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039274 c.1431G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039292 c.1413C>T synonymous_variant 0.26 pyrazinamide
clpC1 4039295 c.1410A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039337 c.1368A>C synonymous_variant 0.19 pyrazinamide
clpC1 4039352 c.1353C>T synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039391 c.1314T>G synonymous_variant 0.3 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.25 pyrazinamide
clpC1 4039484 c.1221T>G synonymous_variant 0.29 pyrazinamide
clpC1 4039493 c.1212C>T synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039514 c.1191C>T synonymous_variant 0.16 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039541 c.1164C>A synonymous_variant 0.16 pyrazinamide
clpC1 4039552 c.1153C>T synonymous_variant 0.28 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039574 p.Ala377Ser missense_variant 0.29 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039601 c.1104G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.32 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039673 c.1032G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039715 c.990G>A synonymous_variant 0.17 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039727 c.978C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.22 pyrazinamide
clpC1 4039766 c.939T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039796 c.909C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039817 c.888A>T synonymous_variant 0.17 pyrazinamide
clpC1 4039820 c.885T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039826 c.879C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.24 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.21 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039955 c.750G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040033 c.672G>C synonymous_variant 0.23 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040091 c.613_614delTCinsAG synonymous_variant 0.26 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040321 c.384C>T synonymous_variant 0.24 pyrazinamide
clpC1 4040342 c.363C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.22 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.19 pyrazinamide
clpC1 4040363 c.342A>T synonymous_variant 0.19 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.17 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.16 pyrazinamide
clpC1 4040480 c.225T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4040522 c.183T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040528 c.177G>C synonymous_variant 0.18 pyrazinamide
clpC1 4040531 c.174T>C synonymous_variant 0.17 pyrazinamide
clpC1 4040551 c.154T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040561 c.144A>G synonymous_variant 0.19 pyrazinamide
clpC1 4040644 c.61A>C synonymous_variant 0.17 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.18 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.16 pyrazinamide
glpK 4138418 c.1338T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138424 c.1332T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4138429 c.1327T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139588 c.168G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139594 c.162C>G synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139600 c.156G>C synonymous_variant 0.23 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139633 c.123C>T synonymous_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139648 c.108T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
glpK 4139651 p.His35Arg missense_variant 0.25 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4239336 c.-527T>C upstream_gene_variant 0.17 ethambutol
embC 4239378 c.-485T>C upstream_gene_variant 0.19 ethambutol
embC 4239401 c.-462A>C upstream_gene_variant 0.18 ethambutol
embC 4240123 c.261C>G synonymous_variant 0.18 ethambutol
embC 4240128 p.Gln89Arg missense_variant 0.19 ethambutol
embC 4240150 c.288A>G synonymous_variant 0.2 ethambutol
embC 4240151 p.Ser97Pro missense_variant 0.2 ethambutol
embC 4240171 c.309G>C synonymous_variant 0.17 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.19 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 0.99 ethambutol Not assoc w R
embA 4244178 p.Ala316Ser missense_variant 0.17 ethambutol
embA 4244198 c.966C>A synonymous_variant 0.17 ethambutol
embA 4244885 c.1653A>G synonymous_variant 0.22 ethambutol
embB 4245983 c.-531A>G upstream_gene_variant 0.14 ethambutol
embB 4245992 c.-522C>G upstream_gene_variant 0.17 ethambutol
embB 4246004 c.-510T>C upstream_gene_variant 0.18 ethambutol
embB 4246005 c.-509C>T upstream_gene_variant 0.18 ethambutol
embB 4246013 c.-501T>C upstream_gene_variant 0.2 ethambutol
embA 4246020 p.Ala930Thr missense_variant 0.2 ethambutol
embA 4246028 c.2796G>C synonymous_variant 0.22 ethambutol Not assoc w R - Interim
embB 4246070 c.-444G>C upstream_gene_variant 0.26 ethambutol
embB 4246082 c.-432T>C upstream_gene_variant 0.3 ethambutol
embB 4246109 c.-405C>G upstream_gene_variant 0.31 ethambutol
embB 4246115 c.-399T>C upstream_gene_variant 0.29 ethambutol
embA 4246128 p.Ser966Thr missense_variant 0.26 ethambutol
embA 4246138 p.Arg969Gln missense_variant 0.23 ethambutol
embB 4246140 c.-374T>C upstream_gene_variant 0.23 ethambutol
embB 4246148 c.-366G>C upstream_gene_variant 0.22 ethambutol
embB 4246151 c.-363A>C upstream_gene_variant 0.19 ethambutol
embA 4246152 p.Ala974Arg missense_variant 0.18 ethambutol
embB 4246172 c.-342C>T upstream_gene_variant 0.2 ethambutol
embB 4246244 c.-270G>A upstream_gene_variant 0.17 ethambutol
embA 4246254 p.Leu1008Met missense_variant 0.19 ethambutol
embB 4246259 c.-255G>C upstream_gene_variant 0.22 ethambutol
embA 4246265 c.3033C>T synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4246268 c.-246G>A upstream_gene_variant 0.17 ethambutol
embA 4246279 p.Ala1016Val missense_variant 0.16 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.18 ethambutol
embB 4246307 c.-207G>C upstream_gene_variant 0.16 ethambutol
embB 4246316 c.-198T>C upstream_gene_variant 0.21 ethambutol
embB 4246346 c.-168C>G upstream_gene_variant 0.22 ethambutol
embA 4246359 p.Ala1043Ser missense_variant 0.21 ethambutol
embB 4246373 c.-141T>C upstream_gene_variant 0.2 ethambutol
embB 4246376 c.-138G>C upstream_gene_variant 0.21 ethambutol
embB 4246567 c.54G>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embB 4247401 c.888T>C synonymous_variant 0.18 ethambutol
embB 4247440 c.927C>G synonymous_variant 0.18 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.38 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.28 ethambutol
embB 4247500 c.987C>G synonymous_variant 0.3 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.29 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.22 ethambutol
embB 4247590 c.1077A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4248007 c.1494C>G synonymous_variant 0.23 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.17 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.18 ethambutol Uncertain significance
embB 4248044 p.Lys511Asp missense_variant 0.18 ethambutol
embB 4248055 c.1542G>C synonymous_variant 0.28 ethambutol
embB 4248064 c.1551G>C synonymous_variant 0.3 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.3 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.19 ethambutol
embB 4248094 c.1581C>T synonymous_variant 0.17 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.18 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.31 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.28 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.19 ethambutol
embB 4248154 c.1641G>T synonymous_variant 0.22 ethambutol
embB 4248157 c.1644A>T synonymous_variant 0.24 ethambutol
embB 4248163 c.1650G>A synonymous_variant 0.22 ethambutol
embB 4248169 c.1656C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embB 4248175 c.1662G>A synonymous_variant 0.21 ethambutol
embB 4248178 c.1665C>T synonymous_variant 0.21 ethambutol
embB 4248206 p.Ser565Gly missense_variant 0.32 ethambutol Uncertain significance
embB 4248217 c.1704C>G synonymous_variant 0.27 ethambutol
embB 4248220 c.1707A>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4248233 c.1720C>T synonymous_variant 0.25 ethambutol
embB 4248277 c.1764G>C synonymous_variant 0.2 ethambutol
embB 4248280 c.1767C>G synonymous_variant 0.19 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.2 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.2 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.18 ethambutol
embB 4248361 c.1848A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embB 4248448 c.1935C>T synonymous_variant 0.2 ethambutol
embB 4248457 c.1944T>C synonymous_variant 0.2 ethambutol
embB 4248472 c.1959T>C synonymous_variant 0.16 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.2 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.23 ethambutol
embB 4249433 c.2920C>T synonymous_variant 0.23 ethambutol
embB 4249444 c.2931T>C synonymous_variant 0.26 ethambutol
embB 4249447 c.2934G>C synonymous_variant 0.26 ethambutol
embB 4249474 c.2961C>T synonymous_variant 0.17 ethambutol
embB 4249486 c.2973T>G synonymous_variant 0.26 ethambutol
embB 4249487 c.2974T>C synonymous_variant 0.26 ethambutol
embB 4249492 c.2979C>G synonymous_variant 0.17 ethambutol
embB 4249501 c.2988C>T synonymous_variant 0.18 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.27 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.23 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.23 ethambutol Uncertain significance
embB 4249540 c.3027C>T synonymous_variant 0.15 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.18 ethambutol
embB 4249568 p.Ser1019Asn missense_variant 0.19 ethambutol
embB 4249573 c.3060T>C synonymous_variant 0.18 ethambutol
embB 4249594 c.3081G>C synonymous_variant 0.18 ethambutol
embB 4249627 c.3114G>C synonymous_variant 0.16 ethambutol
embB 4249640 c.3127T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4249648 c.3135G>C synonymous_variant 0.16 ethambutol
embB 4249693 c.3180T>C synonymous_variant 0.18 ethambutol
embB 4249699 c.3186T>A synonymous_variant 0.18 ethambutol
embB 4249702 c.3189C>A synonymous_variant 0.18 ethambutol
embB 4249703 c.3190C>T synonymous_variant 0.18 ethambutol
aftB 4267556 c.1281G>C synonymous_variant 0.17 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.86 ethambutol Not assoc w R
aftB 4267856 c.981T>C synonymous_variant 0.16 ethambutol
aftB 4267879 p.Val320Leu missense_variant 0.16 ethambutol
aftB 4269164 c.-328T>C upstream_gene_variant 0.21 ethambutol
ubiA 4269177 c.657G>A synonymous_variant 0.24 ethambutol Not assoc w R - Interim
aftB 4269183 c.-347T>C upstream_gene_variant 0.2 ethambutol
aftB 4269210 c.-374G>A upstream_gene_variant 0.19 ethambutol
ubiA 4269222 c.612T>G synonymous_variant 0.27 ethambutol Not assoc w R - Interim
aftB 4269225 c.-389C>A upstream_gene_variant 0.16 ethambutol
aftB 4269234 c.-398A>G upstream_gene_variant 0.27 ethambutol
ubiA 4269243 p.His197Gln missense_variant 0.24 ethambutol
aftB 4269248 c.-412C>T upstream_gene_variant 0.22 ethambutol
ethR 4326556 c.-993A>G upstream_gene_variant 0.18 ethionamide
ethA 4326563 p.Ala304Gly missense_variant 0.16 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R