TB-Profiler result

Run: SRR11342673
Summary

Run ID: SRR11342673

Sample name:

Date: 2024-10-04T20:45:18.623268

Number of reads: 5942844

Percentage reads mapped: 82.67

Median coverage: 97.0

Strain: lineage4.3.4.2

Spoligotype:

Drug-resistance: RR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 1.0
lineage4 Euro-American None 1.0
lineage4.3.4 Euro-American (LAM) RD174 1.0
lineage4.3.4.2 Euro-American (LAM) RD174 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Ser441Ala Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
p.His445Arg Assoc w R
p.Ser450Phe Assoc w R
p.Leu464Met Mutation from literature
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.799C>T Uncertain significance Mutation from literature
n.888G>A Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761127 p.Ser441Ala missense_variant 0.75 rifampicin Assoc w R - Interim Expert rule: Non-silent variants in RRDR of rpoB
rpoB 761140 p.His445Arg missense_variant 0.42 rifampicin Assoc w R
rpoB 761155 p.Ser450Phe missense_variant 0.33 rifampicin Assoc w R
rpoB 761196 p.Leu464Met missense_variant 0.73 rifampicin Mutation from literature
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance Mutation from literature
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.81 streptomycin Uncertain significance Mutation from literature
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.93 amikacin Uncertain significance Mutation from literature
capreomycin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.93 amikacin Assoc w R
capreomycin Assoc w R
kanamycin Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6140 p.Val301Leu missense_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
mshA 576108 p.Ala254Gly missense_variant 0.36 isoniazid
ethionamide
rpoB 761102 c.1296A>G synonymous_variant 0.62 rifampicin
rpoB 761132 c.1326G>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoB 761159 c.1353G>A synonymous_variant 0.76 rifampicin
rpoB 761165 c.1359G>T synonymous_variant 0.74 rifampicin Not assoc w R - Interim
rpoB 761168 c.1362C>G synonymous_variant 0.74 rifampicin
rpoB 761180 c.1374A>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 761186 p.Glu460Asp missense_variant 0.76 rifampicin Uncertain significance
rpoB 761192 c.1386C>A synonymous_variant 0.73 rifampicin
rpoB 761195 c.1389G>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761201 c.1395G>A synonymous_variant 0.69 rifampicin
rpoB 761204 c.1398C>T synonymous_variant 0.7 rifampicin
rpoB 761207 c.1401C>A synonymous_variant 0.69 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.68 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 761231 c.1425C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 761234 c.1428G>T synonymous_variant 0.55 rifampicin
rpoB 761243 c.1437G>C synonymous_variant 0.46 rifampicin
rpoB 761246 c.1440C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762836 c.3030C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoB 762849 p.Tyr1015Asp missense_variant 0.73 rifampicin
rpoB 762855 p.Val1017Ile missense_variant 0.81 rifampicin
rpoB 762858 p.Thr1018Ser missense_variant 0.81 rifampicin
rpoB 762866 c.3060C>T synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoB 762870 p.Met1022Gln missense_variant 0.75 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.87 rifampicin Uncertain significance
rpoC 762902 c.-468C>T upstream_gene_variant 0.84 rifampicin
rpoC 762911 c.-459C>T upstream_gene_variant 0.83 rifampicin
rpoC 762917 c.-453C>T upstream_gene_variant 0.83 rifampicin
rpoB 762920 c.3114C>T synonymous_variant 0.84 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>T synonymous_variant 0.89 rifampicin Not assoc w R - Interim
rpoC 762944 c.-426C>T upstream_gene_variant 0.82 rifampicin
rpoC 762956 c.-414G>C upstream_gene_variant 0.81 rifampicin
rpoB 762962 c.3156C>T synonymous_variant 0.78 rifampicin Not assoc w R - Interim
rpoC 762983 c.-387C>T upstream_gene_variant 0.64 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.74 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 763002 c.3197dupA frameshift_variant 0.3 rifampicin
rpoB 763005 p.Cys1067Gly missense_variant 0.18 rifampicin Uncertain significance
rpoB 763006 p.Cys1067Leu missense_variant 0.26 rifampicin
rpoB 763014 p.Met1070Leu missense_variant 0.4 rifampicin
rpoB 763017 p.Gln1071Glu missense_variant 0.4 rifampicin
rpoC 763022 c.-348C>G upstream_gene_variant 0.24 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763038 p.Thr1078Ala missense_variant 0.38 rifampicin
rpoC 763043 c.-327G>C upstream_gene_variant 0.19 rifampicin
rpoC 763049 c.-321G>A upstream_gene_variant 0.17 rifampicin
rpoC 763053 c.-317_-315delTTGinsCTC upstream_gene_variant 0.35 rifampicin
rpoC 763067 c.-303C>G upstream_gene_variant 0.14 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763077 p.Val1091Thr missense_variant 0.29 rifampicin
rpoC 763109 c.-261C>T upstream_gene_variant 0.18 rifampicin
rpoC 763551 p.Tyr61Ser missense_variant 0.13 rifampicin
rpoC 763570 c.201G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763578 p.Phe70Tyr missense_variant 0.27 rifampicin
rpoC 763597 c.228G>A synonymous_variant 0.27 rifampicin
rpoC 763598 p.Arg77Lys missense_variant 0.27 rifampicin
rpoC 763603 c.234C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763606 c.237C>T synonymous_variant 0.29 rifampicin
rpoC 763609 c.240C>T synonymous_variant 0.32 rifampicin
rpoC 763615 c.246G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>G synonymous_variant 0.44 rifampicin
rpoC 763622 p.Ala85Ser missense_variant 0.48 rifampicin Uncertain significance
rpoC 763642 c.273G>T synonymous_variant 0.66 rifampicin
rpoC 763648 c.279C>T synonymous_variant 0.67 rifampicin
rpoC 763657 p.Glu96Asp missense_variant 0.69 rifampicin
rpoC 763666 c.297G>C synonymous_variant 0.72 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.66 rifampicin
rpoC 763708 c.339G>A synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoC 763714 c.345G>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763718 p.Leu117Val missense_variant 0.58 rifampicin
rpoC 763726 c.357C>T synonymous_variant 0.57 rifampicin
rpoC 763732 c.363C>T synonymous_variant 0.59 rifampicin
rpoC 763747 c.378G>A synonymous_variant 0.55 rifampicin
rpoC 763751 p.Ile128Val missense_variant 0.58 rifampicin
rpoC 763772 p.Val135Met missense_variant 0.45 rifampicin
rpoC 764582 p.Leu405Met missense_variant 0.51 rifampicin
rpoC 764587 c.1218C>G synonymous_variant 0.74 rifampicin
rpoC 764593 c.1224C>T synonymous_variant 0.86 rifampicin
rpoC 764602 c.1233C>T synonymous_variant 0.91 rifampicin
rpoC 764605 c.1236G>T synonymous_variant 0.91 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.94 rifampicin Not assoc w R - Interim
rpoC 764635 c.1266C>T synonymous_variant 0.92 rifampicin
rpoC 764647 c.1278C>T synonymous_variant 0.92 rifampicin
rpoC 764650 c.1281G>T synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764653 c.1284G>C synonymous_variant 0.92 rifampicin
rpoC 764656 c.1287C>G synonymous_variant 0.93 rifampicin
rpoC 764659 c.1290C>T synonymous_variant 0.92 rifampicin
rpoC 764665 c.1296C>T synonymous_variant 0.91 rifampicin
rpoC 764668 c.1299C>T synonymous_variant 0.91 rifampicin Not assoc w R - Interim
rpoC 764671 c.1302G>T synonymous_variant 0.91 rifampicin
rpoC 764677 c.1308C>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 764678 p.Lys437Gln missense_variant 0.91 rifampicin
rpoC 764681 p.Leu438Met missense_variant 0.91 rifampicin
rpoC 764692 c.1323C>T synonymous_variant 0.93 rifampicin Not assoc w R - Interim
rpoC 764706 p.Leu446Gln missense_variant 0.94 rifampicin Uncertain significance
rpoC 764731 c.1362G>C synonymous_variant 0.93 rifampicin
rpoC 764737 c.1368G>T synonymous_variant 0.91 rifampicin
rpoC 764746 c.1377G>T synonymous_variant 0.87 rifampicin Not assoc w R - Interim
rpoC 764755 p.Asp462Glu missense_variant 0.8 rifampicin
rpoC 764758 c.1389C>G synonymous_variant 0.76 rifampicin Not assoc w R - Interim
rpoC 764760 p.Asn464Ser missense_variant 0.75 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoC 764767 c.1398G>T synonymous_variant 0.77 rifampicin
rpoC 764776 c.1407C>T synonymous_variant 0.76 rifampicin
rpoC 764785 c.1416C>T synonymous_variant 0.76 rifampicin
rpoC 764791 c.1422C>T synonymous_variant 0.71 rifampicin
rpoC 764797 c.1428G>T synonymous_variant 0.64 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781802 c.243G>C synonymous_variant 0.17 streptomycin
rpsL 781805 c.246G>T synonymous_variant 0.17 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.17 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.17 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.17 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.16 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.16 streptomycin
rpsL 781838 c.279G>T synonymous_variant 0.16 streptomycin
rrs 1471659 n.-187C>T upstream_gene_variant 0.99 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471866 n.21C>T non_coding_transcript_exon_variant 0.41 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472102 n.257G>A non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.97 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472282 n.437T>G non_coding_transcript_exon_variant 0.73 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.78 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.83 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472416 n.571C>T non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>A non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472498 n.653C>G non_coding_transcript_exon_variant 0.26 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.88 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.83 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472597 n.752G>A non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472607 n.762G>A non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.77 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.77 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.23 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472670 n.825_838delGGGTTTCCTTCCTTinsTAGACCCTTTCCG non_coding_transcript_exon_variant 0.52 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472670 n.825_838delGGGTTTCCTTCCTTinsTGGGTCCTTTCC non_coding_transcript_exon_variant 0.47 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472687 n.842_844delATCinsTTT non_coding_transcript_exon_variant 0.66 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472687 n.842_843insC non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.76 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.64 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.21 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.79 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472755 n.910G>A non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.86 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.97 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.83 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.91 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472880 n.1035G>A non_coding_transcript_exon_variant 0.69 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.98 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.85 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472955 n.1110C>T non_coding_transcript_exon_variant 0.9 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.97 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.87 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.94 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.94 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.96 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473115 n.1270G>T non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.99 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473270 n.1425G>A non_coding_transcript_exon_variant 0.93 kanamycin Uncertain significance
capreomycin
streptomycin
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 1.0 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443delCinsTT non_coding_transcript_exon_variant 0.56 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.95 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473305 n.1460G>T non_coding_transcript_exon_variant 0.94 kanamycin
capreomycin
streptomycin
amikacin
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.99 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473676 n.19G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473679 n.22T>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473697 n.40C>T non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473718 n.61G>T non_coding_transcript_exon_variant 0.55 capreomycin
linezolid
rrl 1473721 n.64G>A non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1473722 n.65G>T non_coding_transcript_exon_variant 0.61 capreomycin
linezolid
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473744 n.87T>C non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1473746 n.89T>A non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1473747 n.90C>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1473751 n.94C>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1473753 n.96A>G non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1474130 n.473C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474141 n.484G>C non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474142 n.485C>G non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474155 n.498G>A non_coding_transcript_exon_variant 0.78 capreomycin
linezolid
rrl 1474164 n.507C>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474171 n.514C>T non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid
rrl 1474199 n.542G>A non_coding_transcript_exon_variant 0.9 capreomycin
linezolid
rrl 1474202 n.545T>C non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474275 n.618T>G non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474280 n.623C>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1474288 n.631_651delCCTTTTCCTCTCCGGAGGAGGinsTTT non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.95 capreomycin
linezolid
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1474317 n.660G>A non_coding_transcript_exon_variant 0.87 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474353 n.696A>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.91 capreomycin
linezolid
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474383 n.726G>T non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474454 n.797G>A non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.99 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.96 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.99 capreomycin
linezolid
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1474584 n.927C>T non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474636 n.979A>T non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474639 n.982G>C non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474672 n.1015C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474674 n.1017_1018delACinsCA non_coding_transcript_exon_variant 0.98 capreomycin
linezolid
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474694 n.1037C>T non_coding_transcript_exon_variant 0.84 capreomycin
linezolid
rrl 1474710 n.1053_1060delTGGTGTAAinsGTAAGTGAG non_coding_transcript_exon_variant 0.94 capreomycin
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1474723 n.1066G>A non_coding_transcript_exon_variant 0.68 capreomycin
linezolid
rrl 1474734 n.1077G>A non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.94 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474753 n.1096_1097delACinsT non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.81 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474780 n.1123C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474783 n.1126G>A non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474830 n.1173A>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.95 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1474883 n.1226T>C non_coding_transcript_exon_variant 0.93 capreomycin
linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474932 n.1275C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474945 n.1288C>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475672 n.2015C>T non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475673 n.2016T>C non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1475751 n.2094C>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475752 n.2095C>T non_coding_transcript_exon_variant 0.91 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101_2105delACCCGinsGCTCT non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1475758 n.2101_2104delACCC non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475763 n.2106_2108delCAAinsTTT non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.88 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475963 n.2306G>T non_coding_transcript_exon_variant 0.92 capreomycin
linezolid
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.93 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.99 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475993 n.2336C>T non_coding_transcript_exon_variant 0.95 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.99 capreomycin
linezolid Uncertain significance
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.9 capreomycin Uncertain significance
linezolid
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.85 capreomycin
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid
rrl 1476040 n.2383C>T non_coding_transcript_exon_variant 0.82 capreomycin
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.81 capreomycin
linezolid
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476130 n.2473G>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476141 n.2484A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476153 n.2496T>C non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.36 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.97 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476195 n.2538C>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476196 n.2539C>A non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.97 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476204 n.2547C>A non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476210 n.2553G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476211 n.2554G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476212 n.2555T>C non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>C non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476227 n.2570C>T non_coding_transcript_exon_variant 0.47 capreomycin
linezolid Uncertain significance
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.81 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476253 n.2596A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.99 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.86 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476302 n.2645G>A non_coding_transcript_exon_variant 0.84 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.99 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.87 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.89 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.88 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.99 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.18 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.99 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.74 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.66 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.36 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476524 n.2867C>T non_coding_transcript_exon_variant 0.63 capreomycin
linezolid
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.98 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.97 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.96 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476577 n.2920T>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.31 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.96 capreomycin Not assoc w R
linezolid Uncertain significance
rpsA 1833931 c.390C>T synonymous_variant 0.17 pyrazinamide
rpsA 1833940 c.399C>T synonymous_variant 0.43 pyrazinamide
rpsA 1833955 c.414G>T synonymous_variant 0.7 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.73 pyrazinamide
rpsA 1833976 c.435C>T synonymous_variant 0.73 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.74 pyrazinamide
rpsA 1833991 c.450C>A synonymous_variant 0.72 pyrazinamide
rpsA 1833994 c.453G>C synonymous_variant 0.74 pyrazinamide
rpsA 1833997 c.456G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834000 c.459G>T synonymous_variant 0.71 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.7 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.71 pyrazinamide
rpsA 1834023 c.482_483insC frameshift_variant 0.68 pyrazinamide Uncertain significance
rpsA 1834026 c.486delG frameshift_variant 0.67 pyrazinamide Uncertain significance
rpsA 1834030 c.489C>T synonymous_variant 0.64 pyrazinamide
rpsA 1834039 c.498C>T synonymous_variant 0.66 pyrazinamide
rpsA 1834040 p.Lys167Gln missense_variant 0.66 pyrazinamide
rpsA 1834043 p.Glu168Gln missense_variant 0.64 pyrazinamide
rpsA 1834051 c.510G>A synonymous_variant 0.65 pyrazinamide
rpsA 1834054 c.513C>T synonymous_variant 0.65 pyrazinamide
rpsA 1834090 c.549G>T synonymous_variant 0.47 pyrazinamide
rpsA 1834093 c.552G>T synonymous_variant 0.41 pyrazinamide
rpsA 1834195 c.654G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.21 pyrazinamide
rpsA 1834213 c.672G>A synonymous_variant 0.18 pyrazinamide
rpsA 1834219 c.678C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834225 c.684C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834228 c.687C>T synonymous_variant 0.34 pyrazinamide
rpsA 1834231 c.690T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834234 c.693G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834246 c.705G>T synonymous_variant 0.33 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.35 pyrazinamide
rpsA 1834252 c.711C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.33 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.33 pyrazinamide
rpsA 1834294 c.753G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.34 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834307 p.Asp256Gln missense_variant 0.22 pyrazinamide
rpsA 1834312 c.771G>A synonymous_variant 0.2 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.12 pyrazinamide Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
thyA 3073868 p.Thr202Ala missense_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0 pyrazinamide Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
alr 3840719 c.702A>G synonymous_variant 1.0 cycloserine
clpC1 4038287 c.2418C>T synonymous_variant 1.0 pyrazinamide Not assoc w R
clpC1 4039662 p.Gly348Asp missense_variant 0.39 pyrazinamide
clpC1 4039664 c.1041G>T synonymous_variant 0.38 pyrazinamide
clpC1 4039670 p.Val345Ile missense_variant 0.66 pyrazinamide
clpC1 4039694 c.1011G>T synonymous_variant 0.82 pyrazinamide
clpC1 4039709 c.996C>T synonymous_variant 0.8 pyrazinamide
clpC1 4039714 p.Tyr331His missense_variant 0.78 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.76 pyrazinamide
clpC1 4039730 c.975C>G synonymous_variant 0.76 pyrazinamide
clpC1 4039733 c.972G>C synonymous_variant 0.74 pyrazinamide
clpC1 4039739 c.966C>A synonymous_variant 0.74 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.74 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.71 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.72 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.72 pyrazinamide
clpC1 4039763 c.942C>A synonymous_variant 0.71 pyrazinamide
clpC1 4039769 c.936C>G synonymous_variant 0.7 pyrazinamide
clpC1 4039773 p.Lys311Met missense_variant 0.68 pyrazinamide
clpC1 4039775 c.930G>C synonymous_variant 0.69 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.69 pyrazinamide
clpC1 4039781 c.924G>C synonymous_variant 0.7 pyrazinamide
clpC1 4039787 c.918G>C synonymous_variant 0.73 pyrazinamide
clpC1 4039793 c.912C>T synonymous_variant 0.74 pyrazinamide
clpC1 4039799 c.906C>T synonymous_variant 0.73 pyrazinamide
clpC1 4039811 c.894C>A synonymous_variant 0.69 pyrazinamide
clpC1 4039817 c.888A>T synonymous_variant 0.56 pyrazinamide
clpC1 4039820 c.885T>A synonymous_variant 0.5 pyrazinamide
clpC1 4039826 c.879C>T synonymous_variant 0.38 pyrazinamide
clpC1 4039829 c.874_876delTTGinsCTC synonymous_variant 0.36 pyrazinamide
clpC1 4039838 p.Leu289Ile missense_variant 0.4 pyrazinamide
clpC1 4039847 c.858C>T synonymous_variant 0.41 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.43 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.46 pyrazinamide
clpC1 4039873 p.Thr278Ser missense_variant 0.46 pyrazinamide Uncertain significance
clpC1 4039875 p.Asn277Arg missense_variant 0.46 pyrazinamide
clpC1 4039880 c.825G>A synonymous_variant 0.46 pyrazinamide
clpC1 4039886 c.819C>G synonymous_variant 0.5 pyrazinamide
clpC1 4039889 c.816G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.63 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.62 pyrazinamide
clpC1 4039907 c.798G>A synonymous_variant 0.62 pyrazinamide Not assoc w R - Interim
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.59 pyrazinamide
clpC1 4039934 c.771G>A synonymous_variant 0.57 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.57 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.56 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.57 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.57 pyrazinamide
clpC1 4039967 p.Gln246His missense_variant 0.57 pyrazinamide
clpC1 4039982 c.723G>C synonymous_variant 0.6 pyrazinamide
clpC1 4039985 c.720G>A synonymous_variant 0.56 pyrazinamide
clpC1 4039991 c.714G>T synonymous_variant 0.57 pyrazinamide
clpC1 4039994 p.Glu237Asp missense_variant 0.58 pyrazinamide
clpC1 4039997 c.708C>T synonymous_variant 0.65 pyrazinamide Not assoc w R - Interim
clpC1 4040009 c.696C>T synonymous_variant 0.74 pyrazinamide
clpC1 4040015 c.690G>A synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4040021 c.684A>C synonymous_variant 0.76 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.77 pyrazinamide
clpC1 4040027 c.678C>G synonymous_variant 0.78 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.79 pyrazinamide
clpC1 4040042 c.663C>T synonymous_variant 0.78 pyrazinamide Not assoc w R - Interim
clpC1 4040057 c.648C>T synonymous_variant 0.78 pyrazinamide
clpC1 4040060 c.645C>T synonymous_variant 0.78 pyrazinamide
clpC1 4040069 c.636G>C synonymous_variant 0.78 pyrazinamide
clpC1 4040081 c.624C>T synonymous_variant 0.77 pyrazinamide
clpC1 4040084 c.621C>T synonymous_variant 0.78 pyrazinamide
clpC1 4040087 c.618G>C synonymous_variant 0.79 pyrazinamide
clpC1 4040090 c.615T>C synonymous_variant 0.79 pyrazinamide Not assoc w R - Interim
clpC1 4040096 c.609G>C synonymous_variant 0.78 pyrazinamide
clpC1 4040108 c.597G>C synonymous_variant 0.79 pyrazinamide
clpC1 4040111 c.594G>A synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4040114 p.Ile197Met missense_variant 0.79 pyrazinamide
clpC1 4040117 c.588A>G synonymous_variant 0.79 pyrazinamide
clpC1 4040123 p.Glu194His missense_variant 0.82 pyrazinamide
clpC1 4040147 p.Lys186Glu missense_variant 0.68 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R