TB-Profiler result

Run: SRR1049675
Summary

Run ID: SRR1049675

Sample name:

Date: 2024-04-16T05:28:49.962134

Number of reads: 2162106

Percentage reads mapped: 54.89

Median coverage: 44.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: HR-TB

Download CSV Download TXT Download JSON
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.84
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Ile Assoc w R
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin rrs n.1401A>G Assoc w R
n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
capreomycin rrs n.1401A>G Assoc w R
n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
kanamycin rrs n.1401A>G Assoc w R
n.1402C>A Uncertain significance Mutation from literature
n.1484G>T Assoc w R
cycloserine
ethionamide ethA p.Tyr60* Assoc w R
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1473246 n.1401A>G non_coding_transcript_exon_variant 0.33 kanamycin Assoc w R
amikacin Assoc w R
capreomycin Assoc w R
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance Mutation from literature
kanamycin Uncertain significance Mutation from literature
amikacin Uncertain significance Mutation from literature
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.59 kanamycin Assoc w R
amikacin Assoc w R
capreomycin Assoc w R
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
embB 4247431 p.Met306Ile missense_variant 1.0 ethambutol Assoc w R
ethA 4327294 p.Tyr60* stop_gained 0.98 ethionamide Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8897 c.1596T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8906 c.1605C>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8907 p.Ser536Ala missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 8915 c.1614A>G synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8939 c.1638T>C synonymous_variant 0.35 levofloxacin
moxifloxacin
gyrA 8942 c.1641G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8945 c.1644G>C synonymous_variant 0.33 levofloxacin
moxifloxacin
gyrA 8946 c.1645_1647delTTGinsCT frameshift_variant&synonymous_variant 0.32 levofloxacin
moxifloxacin
gyrA 8981 c.1680G>C synonymous_variant 0.32 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8982 p.Cys561Ser missense_variant 0.32 levofloxacin
moxifloxacin
gyrA 8996 c.1695T>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.32 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9016 p.Thr572Asn missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9018 p.Gln573Lys missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9024 c.1723C>A synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9032 c.1731T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 0.98 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.98 ethionamide Uncertain significance
hadA 732277 c.348C>T synonymous_variant 1.0 isoniazid Not assoc w R - Interim
rpoB 760917 c.1111_1113delCGCinsAG frameshift_variant&missense_variant 0.25 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.22 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>A synonymous_variant 0.25 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760953 p.Ile383Val missense_variant 0.24 rifampicin
rpoB 760956 c.1150C>A synonymous_variant 0.24 rifampicin
rpoB 760964 c.1158C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.24 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>C synonymous_variant 0.24 rifampicin
rpoB 760991 c.1185G>C synonymous_variant 0.21 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761347 p.Val514Glu missense_variant 0.22 rifampicin
rpoB 761355 p.Val517Lys missense_variant 0.2 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.19 rifampicin
rpoB 761367 p.Glu521Gln missense_variant 0.17 rifampicin
rpoB 761374 p.Val523Asp missense_variant 0.18 rifampicin
rpoB 761396 c.1590G>A synonymous_variant 0.17 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.2 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.24 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.24 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.24 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.27 rifampicin
rpoB 761917 p.Asp704Gly missense_variant 0.24 rifampicin
rpoB 761937 p.Lys711Arg missense_variant 0.21 rifampicin Uncertain significance
rpoB 761951 c.2145G>C synonymous_variant 0.19 rifampicin
rpoB 761955 p.Ile717Phe missense_variant 0.19 rifampicin
rpoB 761972 c.2166C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761980 p.Tyr725Phe missense_variant 0.21 rifampicin
rpoB 762053 c.2247T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762084 c.2278_2280delGCGinsCC frameshift_variant&missense_variant 0.17 rifampicin
rpoB 762099 c.2293_2295delCGCinsAG frameshift_variant&missense_variant 0.15 rifampicin
rpoB 762110 c.2304G>C synonymous_variant 0.15 rifampicin
rpoB 762114 p.Ile770Val missense_variant 0.18 rifampicin Uncertain significance
rpoB 762122 p.Asp772Glu missense_variant 0.25 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.28 rifampicin
rpoB 762134 c.2328C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762143 c.2337T>C synonymous_variant 0.32 rifampicin
rpoB 762149 c.2343G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762161 c.2355C>G synonymous_variant 0.37 rifampicin
rpoB 762176 c.2370T>G synonymous_variant 0.41 rifampicin
rpoB 762178 p.Arg791Gln missense_variant 0.41 rifampicin
rpoB 762185 c.2379G>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>C synonymous_variant 0.53 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762254 c.2448T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 762257 c.2451C>G synonymous_variant 0.39 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.36 rifampicin
rpoB 762278 c.2472C>T synonymous_variant 0.36 rifampicin
rpoB 762293 c.2487T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762299 c.2493G>C synonymous_variant 0.22 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762318 p.Ser838Thr missense_variant 0.16 rifampicin
rpoB 762329 c.2523G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762404 c.2598T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.16 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762426 p.Ser874Gln missense_variant 0.2 rifampicin
rpoC 762434 c.-936T>C upstream_gene_variant 0.21 rifampicin
rpoC 762443 c.-927G>C upstream_gene_variant 0.22 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 762491 c.-879T>G upstream_gene_variant 0.27 rifampicin
rpoC 762503 c.-867G>C upstream_gene_variant 0.31 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.26 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.26 rifampicin
rpoC 762527 c.-843G>C upstream_gene_variant 0.25 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.22 rifampicin
rpoB 762534 c.2728_2730delATTinsGG frameshift_variant&missense_variant 0.22 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.23 rifampicin
rpoB 762543 c.2737_2739delACCinsCG frameshift_variant&missense_variant 0.23 rifampicin
rpoB 762858 c.3052_3054delACGinsGC frameshift_variant&missense_variant 0.44 rifampicin
rpoB 762863 c.3057T>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762878 p.Ile1024Met missense_variant 0.5 rifampicin
rpoB 762879 p.Met1025Leu missense_variant 0.51 rifampicin Uncertain significance
rpoB 762888 p.His1028Asn missense_variant 0.54 rifampicin
rpoB 762918 c.3112_3114delCGCinsAG frameshift_variant&missense_variant 0.58 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>C synonymous_variant 0.63 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.42 rifampicin Not assoc w R
rpoB 763031 c.3225T>G synonymous_variant 0.57 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoC 763052 c.-318G>C upstream_gene_variant 0.5 rifampicin
rpoC 763065 c.-305_-304delTCinsAG upstream_gene_variant 0.41 rifampicin
rpoB 763070 c.3264T>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763075 p.Thr1090Ile missense_variant 0.47 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763103 c.-267G>C upstream_gene_variant 0.42 rifampicin
rpoB 763104 c.3298_3300delATCinsGG frameshift_variant&missense_variant 0.42 rifampicin
rpoC 763109 c.-261C>G upstream_gene_variant 0.43 rifampicin
rpoB 763115 c.3309T>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763169 c.-201A>G upstream_gene_variant 0.3 rifampicin
rpoB 763176 p.Ser1124Ala missense_variant 0.23 rifampicin Uncertain significance
rpoC 763187 c.-183C>G upstream_gene_variant 0.13 rifampicin
rpoC 763465 c.96G>A synonymous_variant 0.17 rifampicin
rpoC 763468 c.99G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763480 c.111C>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763483 c.114G>C synonymous_variant 0.32 rifampicin
rpoC 763486 c.117T>G synonymous_variant 0.33 rifampicin
rpoC 763504 c.135C>G synonymous_variant 0.48 rifampicin
rpoC 763507 c.138G>C synonymous_variant 0.5 rifampicin
rpoC 763528 c.159G>C synonymous_variant 0.63 rifampicin
rpoC 763531 c.162G>C synonymous_variant 0.61 rifampicin Not assoc w R
rpoC 763534 c.165T>C synonymous_variant 0.6 rifampicin
rpoC 763537 c.168C>G synonymous_variant 0.62 rifampicin
rpoC 763546 c.177A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 763550 p.Tyr61Ala missense_variant 0.61 rifampicin
rpoC 763594 c.225C>T synonymous_variant 0.59 rifampicin Not assoc w R - Interim
rpoC 763621 c.252C>T synonymous_variant 0.54 rifampicin
rpoC 763630 c.261G>A synonymous_variant 0.49 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.5 rifampicin
rpoC 763648 c.279C>T synonymous_variant 0.47 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>T synonymous_variant 0.45 rifampicin
rpoC 763669 c.300C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763703 c.334_336delTCGinsAGC synonymous_variant 0.29 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.3 rifampicin
rpoC 763714 c.345G>T synonymous_variant 0.3 rifampicin
rpoC 763717 c.348T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.32 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.34 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.34 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.35 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.35 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.3 rifampicin
rpoC 763772 p.Val135Leu missense_variant 0.24 rifampicin
rpoC 764246 p.Leu293Ile missense_variant 0.19 rifampicin Uncertain significance
rpoC 764266 c.897T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764269 c.900G>C synonymous_variant 0.23 rifampicin
rpoC 764278 c.909delAinsGGC frameshift_variant&synonymous_variant 0.24 rifampicin
rpoC 764284 c.915G>C synonymous_variant 0.33 rifampicin
rpoC 764297 p.Met310Leu missense_variant 0.37 rifampicin
rpoC 764311 c.942C>G synonymous_variant 0.39 rifampicin
rpoC 764315 p.Ala316Cys missense_variant 0.38 rifampicin
rpoC 764339 c.970_972delCTGinsAC frameshift_variant&missense_variant 0.4 rifampicin
rpoC 764428 c.1059G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764429 c.1060C>T synonymous_variant 0.26 rifampicin
rpoC 764434 c.1065A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764443 p.Ile358Met missense_variant 0.24 rifampicin
rpoC 764446 c.1077T>C synonymous_variant 0.24 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.24 rifampicin
rpoC 764452 c.1083T>C synonymous_variant 0.27 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764498 p.Ser377Ala missense_variant 0.32 rifampicin
rpoC 764503 c.1134G>C synonymous_variant 0.31 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>T synonymous_variant 0.44 rifampicin
rpoC 764536 c.1167G>C synonymous_variant 0.51 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764578 c.1209C>G synonymous_variant 0.59 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.45 rifampicin
rpoC 764656 c.1287C>G synonymous_variant 0.44 rifampicin
rpoC 764662 c.1293G>C synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764677 c.1308C>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 764690 p.Cys441Ala missense_variant 0.41 rifampicin
rpoC 764695 c.1326T>C synonymous_variant 0.4 rifampicin
rpoC 764701 c.1332C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>A synonymous_variant 0.31 rifampicin
rpoC 764752 c.1383G>T synonymous_variant 0.31 rifampicin
rpoC 764758 c.1389C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764759 p.Asn464Gly missense_variant 0.26 rifampicin
rpoC 764764 c.1395T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764767 c.1398G>C synonymous_variant 0.28 rifampicin
rpoC 764780 c.1411_1412delAGinsTC synonymous_variant 0.3 rifampicin
rpoC 764791 c.1422C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764812 c.1443C>G synonymous_variant 0.37 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.33 rifampicin
rpoC 764833 c.1464A>G synonymous_variant 0.33 rifampicin
rpoC 764844 p.Ala492Gly missense_variant 0.34 rifampicin
rpoC 764847 p.Glu493Ala missense_variant 0.35 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>T synonymous_variant 0.41 rifampicin
rpoC 764893 c.1524T>C synonymous_variant 0.35 rifampicin
rpoC 764902 c.1533C>G synonymous_variant 0.36 rifampicin
rpoC 764911 c.1542A>G synonymous_variant 0.32 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.3 rifampicin Uncertain significance
rpoC 764920 c.1551G>C synonymous_variant 0.31 rifampicin
rpoC 764923 c.1554A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.31 rifampicin
rpoC 764939 c.1570C>T synonymous_variant 0.3 rifampicin
rpoC 764958 p.Glu530Ala missense_variant 0.27 rifampicin
rpoC 764968 c.1599T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765932 p.Gly855Ser missense_variant 0.19 rifampicin Uncertain significance
rpoC 765937 c.2568T>G synonymous_variant 0.19 rifampicin
rpoC 765967 c.2598C>G synonymous_variant 0.22 rifampicin
rpoC 765976 p.Asp869Glu missense_variant 0.23 rifampicin Uncertain significance
rpoC 765979 c.2610C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765997 c.2628T>G synonymous_variant 0.21 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777597 p.Arg295Pro missense_variant 0.98 clofazimine
bedaquiline
mmpS5 779615 c.-710C>G upstream_gene_variant 0.93 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781772 c.213C>A synonymous_variant 0.29 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.36 streptomycin
rpsL 781796 p.Met79Ile missense_variant 0.41 streptomycin
rpsL 781805 c.246G>C synonymous_variant 0.47 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.49 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.51 streptomycin
rpsL 781835 c.276T>C synonymous_variant 0.51 streptomycin Not assoc w R - Interim
rpsL 781838 c.279G>T synonymous_variant 0.51 streptomycin
rpsL 781841 c.282C>T synonymous_variant 0.51 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.45 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.45 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.44 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.42 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.42 streptomycin
rplC 800600 c.-209G>C upstream_gene_variant 0.14 linezolid
rplC 800606 c.-203G>T upstream_gene_variant 0.15 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.18 linezolid
rplC 800615 c.-194G>C upstream_gene_variant 0.17 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.17 linezolid
rplC 800630 c.-179G>T upstream_gene_variant 0.18 linezolid
rplC 800633 c.-176T>C upstream_gene_variant 0.19 linezolid
rplC 800648 c.-161A>G upstream_gene_variant 0.3 linezolid
rplC 800672 c.-137G>C upstream_gene_variant 0.45 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.4 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.35 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.32 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.3 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.29 linezolid
rplC 800729 c.-80G>C upstream_gene_variant 0.27 linezolid
rplC 800735 c.-74C>G upstream_gene_variant 0.27 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.2 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471923 n.78T>C non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.47 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471932 n.87A>G non_coding_transcript_exon_variant 0.49 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.49 streptomycin Uncertain significance
kanamycin
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1471972 n.127T>C non_coding_transcript_exon_variant 0.2 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471979 n.134delTinsCTA non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471982 n.137A>T non_coding_transcript_exon_variant 0.21 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471984 n.140_141delTC non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin
capreomycin
amikacin
rrs 1471997 n.152T>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472005 n.160T>C non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.18 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.48 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.51 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472122 n.277G>A non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472326 n.481T>A non_coding_transcript_exon_variant 0.28 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472328 n.483G>C non_coding_transcript_exon_variant 0.31 streptomycin Uncertain significance
kanamycin
capreomycin
amikacin
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Uncertain significance
rrs 1472426 n.581T>C non_coding_transcript_exon_variant 0.23 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472494 n.649A>T non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.37 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472506 n.661A>T non_coding_transcript_exon_variant 0.48 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472572 n.727T>A non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472583 n.738T>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.4 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.35 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.33 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472674 n.829T>A non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.32 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.29 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472686 n.841G>T non_coding_transcript_exon_variant 0.29 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472687 n.842A>C non_coding_transcript_exon_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.43 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.5 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.52 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472791 n.946G>T non_coding_transcript_exon_variant 0.58 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.22 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.36 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.73 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472987 n.1142G>A non_coding_transcript_exon_variant 0.72 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.73 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Not assoc w R
rrs 1473065 n.1220C>A non_coding_transcript_exon_variant 0.66 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473097 n.1252G>A non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.6 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.6 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.61 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.62 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.63 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473122 n.1277T>A non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.69 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473158 n.1313T>C non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.66 streptomycin Uncertain significance
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.68 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.65 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473291 n.1446_1447insT non_coding_transcript_exon_variant 0.67 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.67 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473691 n.34T>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473696 n.39T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473698 n.41G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473707 n.50T>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1473713 n.56A>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1473717 n.60G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473731 n.74T>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473746 n.89T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1473756 n.99G>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473757 n.100T>G non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473771 n.114T>A non_coding_transcript_exon_variant 0.4 capreomycin
linezolid
rrl 1473788 n.131A>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473792 n.135C>G non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473797 n.140G>C non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1473803 n.146G>C non_coding_transcript_exon_variant 0.39 capreomycin
linezolid
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid
rrl 1473815 n.158T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473821 n.164T>C non_coding_transcript_exon_variant 0.44 capreomycin
linezolid
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1473833 n.176_177insT non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473844 n.187C>T non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473870 n.213G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473871 n.214T>C non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473883 n.226A>G non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473887 n.230T>A non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1473888 n.231T>C non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473890 n.233T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>T non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474127 n.470G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474139 n.482C>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474153 n.496C>G non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474166 n.509G>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.58 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474201 n.544T>C non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474202 n.545T>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474263 n.606G>A non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474275 n.618T>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474281 n.624A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474316 n.659T>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474348 n.691C>T non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474351 n.694G>T non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474353 n.696A>G non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474354 n.697C>T non_coding_transcript_exon_variant 0.42 capreomycin
linezolid
rrl 1474359 n.702C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474381 n.724T>A non_coding_transcript_exon_variant 0.37 capreomycin
linezolid
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474466 n.809G>A non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474488 n.831G>A non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.55 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474516 n.859C>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.59 capreomycin
linezolid
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.6 capreomycin
linezolid
rrl 1474583 n.926C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474651 n.995delT non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474742 n.1085A>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474751 n.1094G>A non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474779 n.1122G>A non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474784 n.1127C>T non_coding_transcript_exon_variant 0.57 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474837 n.1180A>G non_coding_transcript_exon_variant 0.65 capreomycin
linezolid
rrl 1474869 n.1212G>T non_coding_transcript_exon_variant 0.63 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474901 n.1244A>G non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475060 n.1404delC non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475065 n.1409_1410delCA non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475079 n.1422T>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475080 n.1423G>C non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1475081 n.1424C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475084 n.1427G>A non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.37 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475116 n.1459G>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475499 n.1842C>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475536 n.1879C>T non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475538 n.1881T>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475539 n.1882A>T non_coding_transcript_exon_variant 0.34 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>C non_coding_transcript_exon_variant 0.35 capreomycin
linezolid
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475573 n.1916G>A non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475649 n.1992A>G non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475655 n.1998T>C non_coding_transcript_exon_variant 0.38 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475688 n.2031G>A non_coding_transcript_exon_variant 0.47 capreomycin
linezolid
rrl 1475692 n.2035G>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1475707 n.2050T>C non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid
rrl 1475713 n.2056C>T non_coding_transcript_exon_variant 0.52 capreomycin
linezolid
rrl 1475753 n.2096C>G non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1475758 n.2101delAinsGTT non_coding_transcript_exon_variant 0.31 capreomycin
linezolid
rrl 1475761 n.2104C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.29 capreomycin Uncertain significance
linezolid
rrl 1475764 n.2107A>G non_coding_transcript_exon_variant 0.3 capreomycin
linezolid Uncertain significance
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.3 capreomycin Uncertain significance
linezolid
rrl 1475767 n.2110G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475769 n.2112T>C non_coding_transcript_exon_variant 0.34 capreomycin
linezolid
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.45 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>G non_coding_transcript_exon_variant 0.76 capreomycin Uncertain significance
linezolid
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.56 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476000 n.2343G>A non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476025 n.2368G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.33 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.49 capreomycin
linezolid
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.53 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.54 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.55 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476213 n.2556G>T non_coding_transcript_exon_variant 0.54 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476229 n.2572C>A non_coding_transcript_exon_variant 0.48 capreomycin
linezolid
rrl 1476279 n.2622G>A non_coding_transcript_exon_variant 0.4 capreomycin Uncertain significance
linezolid
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476297 n.2640C>A non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476300 n.2643G>T non_coding_transcript_exon_variant 0.38 capreomycin
linezolid
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476423 n.2766T>C non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.71 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.6 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476529 n.2872A>T non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.51 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.5 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.49 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.48 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.46 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.44 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833646 c.105T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
rpsA 1833666 p.Thr42Ser missense_variant 0.32 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833677 c.136_138delGTGinsAC frameshift_variant&missense_variant 0.31 pyrazinamide Uncertain significance
rpsA 1833685 c.144G>C synonymous_variant 0.44 pyrazinamide
rpsA 1833697 c.156C>G synonymous_variant 0.46 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.52 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.48 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.45 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.16 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.33 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.34 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.35 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.35 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.41 pyrazinamide
rpsA 1834012 c.471G>T synonymous_variant 0.45 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.47 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.39 pyrazinamide
rpsA 1834034 p.Ile165Val missense_variant 0.35 pyrazinamide
rpsA 1834040 p.Lys167Arg missense_variant 0.29 pyrazinamide
rpsA 1834043 p.Glu168Gln missense_variant 0.27 pyrazinamide
rpsA 1834046 c.505_507delATCinsCG frameshift_variant&missense_variant 0.27 pyrazinamide Uncertain significance
rpsA 1834051 p.Glu170Asp missense_variant 0.26 pyrazinamide
rpsA 1834069 c.528G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834195 c.654G>C synonymous_variant 0.12 pyrazinamide
rpsA 1834213 c.672G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.36 pyrazinamide
rpsA 1834240 c.699T>C synonymous_variant 0.38 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.44 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.5 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.52 pyrazinamide
rpsA 1834298 p.Gln253Glu missense_variant 0.48 pyrazinamide
rpsA 1834303 c.762T>C synonymous_variant 0.47 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.46 pyrazinamide
rpsA 1834307 c.766_768delGACinsCG frameshift_variant&missense_variant 0.47 pyrazinamide Uncertain significance
rpsA 1834312 c.771G>A synonymous_variant 0.48 pyrazinamide
rpsA 1834330 c.789C>T synonymous_variant 0.48 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 0.47 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.46 pyrazinamide Not assoc w R - Interim
rpsA 1834357 c.816T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834361 c.820T>C synonymous_variant 0.43 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.4 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.38 pyrazinamide
rpsA 1834378 c.837T>C synonymous_variant 0.38 pyrazinamide Not assoc w R - Interim
rpsA 1834387 c.846C>T synonymous_variant 0.43 pyrazinamide
rpsA 1834390 c.849G>C synonymous_variant 0.45 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.42 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.4 pyrazinamide
rpsA 1834438 c.897C>T synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
rpsA 1834439 p.Lys300Arg missense_variant 0.36 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.32 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.3 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834477 c.936C>G synonymous_variant 0.14 pyrazinamide
katG 2154239 p.Thr625Ala missense_variant 1.0 isoniazid Uncertain significance
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv2477c 2782900 c.1143C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782903 c.1140C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782913 p.Ser377Asn missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Gln missense_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>C synonymous_variant 0.43 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.39 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.4 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 0.96 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626548 c.66C>T synonymous_variant 0.96 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
mtrB 3626562 p.Pro18Ser missense_variant 0.96 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3878053 p.Asn152Ser missense_variant 1.0 rifampicin
clpC1 4038743 c.1962G>C synonymous_variant 0.23 pyrazinamide
clpC1 4038749 c.1956C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4038755 c.1950G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038764 c.1941C>T synonymous_variant 0.45 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.52 pyrazinamide
clpC1 4038779 c.1926C>G synonymous_variant 0.58 pyrazinamide
clpC1 4038794 p.Ser637Thr missense_variant 0.57 pyrazinamide
clpC1 4038810 p.Gln632Pro missense_variant 0.6 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.62 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.48 pyrazinamide Not assoc w R - Interim
clpC1 4038939 p.Phe589Tyr missense_variant 0.17 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.18 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038983 p.Asp574Glu missense_variant 0.17 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039001 c.1702_1704delAACinsGA frameshift_variant&missense_variant 0.16 pyrazinamide
clpC1 4039007 c.1698G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039018 p.Ser563Thr missense_variant 0.28 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039028 c.1677G>A synonymous_variant 0.33 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039067 c.1638G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039073 c.1632C>A synonymous_variant 0.3 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4039082 c.1623C>T synonymous_variant 0.29 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039091 c.1614G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039239 p.Gly489Ala missense_variant 0.15 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039508 c.1197G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.2 pyrazinamide
clpC1 4039524 p.Phe394Tyr missense_variant 0.19 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.12 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.14 pyrazinamide
clpC1 4039670 c.1033_1035delGTGinsAC frameshift_variant&missense_variant 0.14 pyrazinamide
clpC1 4039682 c.1023C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039685 c.1020C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039697 c.1006_1008delGCCinsCG frameshift_variant&synonymous_variant 0.29 pyrazinamide
clpC1 4039711 p.Ile332Val missense_variant 0.13 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.18 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.22 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040084 c.621C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040348 c.357G>C synonymous_variant 0.32 pyrazinamide
clpC1 4040351 c.354C>T synonymous_variant 0.32 pyrazinamide
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 0.95 streptomycin Not assoc w R