TB-Profiler result

Run: ERR2512770
Summary

Run ID: ERR2512770

Sample name:

Date: 2024-10-04T10:48:59.108400

Number of reads: 1571137

Percentage reads mapped: 63.12

Median coverage: 45.0

Strain: lineage4.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.2 Euro-American None 0.94
lineage4 Euro-American None 1.0
lineage4.2.1 Euro-American (TUR) None 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 660 c.660G>C synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 663 c.663A>C synonymous_variant 0.19 isoniazid
dnaA 666 c.666C>G synonymous_variant 0.16 isoniazid
dnaA 678 c.678A>G synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 682 c.682_684delTTGinsCTC synonymous_variant 0.17 isoniazid
dnaA 687 c.687C>T synonymous_variant 0.19 isoniazid
dnaA 693 c.693A>C synonymous_variant 0.23 isoniazid
dnaA 705 c.705A>G synonymous_variant 0.26 isoniazid
dnaA 708 c.708T>C synonymous_variant 0.27 isoniazid
dnaA 714 c.714C>T synonymous_variant 0.31 isoniazid
dnaA 720 c.720G>A synonymous_variant 0.33 isoniazid
dnaA 741 c.741T>C synonymous_variant 0.29 isoniazid Not assoc w R - Interim
dnaA 747 c.747G>T synonymous_variant 0.26 isoniazid
dnaA 748 c.748_750delCTCinsTTG synonymous_variant 0.25 isoniazid
dnaA 763 p.Lys255Arg missense_variant 0.26 isoniazid
dnaA 771 c.771A>G synonymous_variant 0.25 isoniazid
dnaA 793 p.Val265Ile missense_variant 0.2 isoniazid Uncertain significance
dnaA 801 c.801G>T synonymous_variant 0.2 isoniazid
dnaA 804 c.804G>C synonymous_variant 0.2 isoniazid
dnaA 805 c.805_807delTTGinsCTC synonymous_variant 0.2 isoniazid
dnaA 822 c.822A>G synonymous_variant 0.24 isoniazid
dnaA 828 c.828T>C synonymous_variant 0.23 isoniazid Not assoc w R - Interim
dnaA 837 c.837A>G synonymous_variant 0.17 isoniazid
dnaA 840 c.840G>A synonymous_variant 0.17 isoniazid
dnaA 846 c.846T>C synonymous_variant 0.16 isoniazid
dnaA 849 c.849A>G synonymous_variant 0.16 isoniazid
dnaA 852 c.852G>A synonymous_variant 0.16 isoniazid Not assoc w R - Interim
dnaA 885 c.885T>C synonymous_variant 0.18 isoniazid
dnaA 888 c.888C>G synonymous_variant 0.18 isoniazid
dnaA 897 c.897A>G synonymous_variant 0.18 isoniazid
dnaA 903 c.903C>G synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 909 c.909A>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 912 c.912T>C synonymous_variant 0.17 isoniazid
dnaA 918 c.918C>G synonymous_variant 0.17 isoniazid
dnaA 929 p.Gln310Arg missense_variant 0.13 isoniazid Uncertain significance
gyrB 6346 c.1107C>T synonymous_variant 1.0 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6676 c.-626T>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 6706 c.-596G>A upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6712 c.-590G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 6727 c.-575G>T upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6728 c.-574_-572delCTAinsTTG upstream_gene_variant 0.16 levofloxacin
moxifloxacin
gyrA 6739 c.-563C>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6745 c.1506T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 6754 c.-548C>T upstream_gene_variant 0.15 levofloxacin
moxifloxacin
gyrB 6763 c.1524G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6793 c.1554T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6798 p.Gly520Ala missense_variant 0.15 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 7060 c.1821T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7093 c.1854T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 7100 c.1861T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7123 c.-179C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7126 c.1887G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7129 c.-173T>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7132 c.-170T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7135 c.-167G>A upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7136 c.-166T>C upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7141 c.-161T>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 7144 c.-158A>G upstream_gene_variant 0.19 levofloxacin
moxifloxacin
gyrA 7150 c.-152G>A upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrB 7153 c.1914G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7168 c.-134C>G upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7178 c.-124T>C upstream_gene_variant 0.17 levofloxacin
moxifloxacin
gyrB 7186 c.1947C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7511 c.210C>T synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>A synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrA 7532 c.231T>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7541 c.240C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7547 c.246C>T synonymous_variant 0.38 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7553 c.252C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7595 c.294C>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8897 c.1596T>C synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8915 c.1614A>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8942 c.1641G>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8945 c.1644G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8946 c.1645T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8957 c.1656C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8967 p.Ala556Lys missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8978 c.1677C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8987 c.1686C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8993 c.1692C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8996 c.1695T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8998 p.Leu566Trp missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9018 p.Gln573Lys missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9023 c.1722A>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9026 c.1725G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 9029 c.1728T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 9035 c.1734G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 9044 c.1743C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9047 c.1746C>T synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13781 c.-223C>G upstream_gene_variant 1.0 isoniazid
fgd1 491247 c.465C>T synonymous_variant 0.94 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
ccsA 620328 c.438G>C synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620338 p.Thr150Ala missense_variant 0.17 kanamycin
capreomycin
amikacin
ccsA 620349 c.459A>C synonymous_variant 0.16 kanamycin
capreomycin
amikacin
ccsA 620354 p.Trp155Tyr missense_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620362 p.Ala158Thr missense_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620365 p.Asn159Tyr missense_variant 0.19 kanamycin
capreomycin
amikacin
ccsA 620388 c.498A>C synonymous_variant 0.23 kanamycin
capreomycin
amikacin
ccsA 620397 c.507C>G synonymous_variant 0.21 kanamycin
capreomycin
amikacin
ccsA 620412 c.522T>C synonymous_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620415 c.525T>C synonymous_variant 0.15 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620430 c.540C>T synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620439 c.549T>G synonymous_variant 0.13 kanamycin
capreomycin
amikacin
nusG 734421 c.168A>C synonymous_variant 0.14 rifampicin
nusG 734445 c.192C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
nusG 734452 p.Glu67Gln missense_variant 0.19 rifampicin Uncertain significance
nusG 734460 c.207G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734472 c.219T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
nusG 734475 c.222T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734497 p.Val82Ile missense_variant 0.22 rifampicin Uncertain significance
nusG 734532 c.279A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
nusG 734535 c.282C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
nusG 734538 c.285C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760181 c.375T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760235 c.429T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760256 c.450C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760274 p.Glu156Asp missense_variant 0.18 rifampicin Uncertain significance
rpoB 760276 p.Lys157Met missense_variant 0.18 rifampicin Uncertain significance
rpoB 760283 c.477G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.15 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.16 rifampicin Uncertain significance
rpoB 760382 c.576G>C synonymous_variant 0.17 rifampicin
rpoB 760388 c.582C>T synonymous_variant 0.22 rifampicin
rpoB 760400 c.594G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.21 rifampicin
rpoB 760407 p.Ser201Gly missense_variant 0.21 rifampicin Uncertain significance
rpoB 760415 c.609C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760418 c.612G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760460 c.654G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760502 c.696C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.24 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760541 c.735G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760561 c.757_758delCG frameshift_variant 0.16 rifampicin
rpoB 760567 p.Ser254Trp missense_variant 0.16 rifampicin
rpoB 760568 c.762_763insGC frameshift_variant 0.16 rifampicin
rpoB 760571 c.765G>C synonymous_variant 0.19 rifampicin
rpoB 760588 p.Thr261Ile missense_variant 0.22 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.27 rifampicin
rpoB 760595 c.789C>T synonymous_variant 0.26 rifampicin
rpoB 760596 p.Thr264Pro missense_variant 0.28 rifampicin
rpoB 760608 c.802C>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760611 c.805T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760634 c.828T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760668 p.Thr288Ala missense_variant 0.31 rifampicin Uncertain significance
rpoB 760674 c.868T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760703 c.897C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760721 c.915C>G synonymous_variant 0.23 rifampicin
rpoB 760727 c.921C>G synonymous_variant 0.18 rifampicin
rpoB 760730 c.924T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760817 c.1011A>G synonymous_variant 0.21 rifampicin
rpoB 760820 c.1014T>C synonymous_variant 0.21 rifampicin
rpoB 760826 c.1020C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760830 c.1024T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760858 p.Val351Ala missense_variant 0.28 rifampicin Uncertain significance
rpoB 760862 c.1056G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760865 c.1059C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760886 p.Glu360Asp missense_variant 0.28 rifampicin Uncertain significance
rpoB 760887 p.Thr361Val missense_variant 0.28 rifampicin Uncertain significance
rpoB 760910 c.1104C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 760916 c.1110C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760928 c.1122G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 760943 c.1137C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760965 p.Met387Leu missense_variant 0.16 rifampicin Uncertain significance
rpoB 760970 c.1164G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760973 c.1167G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760988 c.1182C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760997 c.1191G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761051 c.1245G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761054 c.1248G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761060 c.1254C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761063 c.1257C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761084 c.1278C>A synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.34 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.31 rifampicin
rpoB 761132 c.1326G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761147 c.1341C>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>T synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761171 c.1365C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761178 p.Ser458Thr missense_variant 0.31 rifampicin Uncertain significance
rpoB 761186 p.Glu460Asp missense_variant 0.29 rifampicin Uncertain significance
rpoB 761189 c.1383T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761198 c.1392G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761303 c.1497G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761558 c.1752C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761564 c.1758G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761612 c.1806G>T synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761948 c.2142G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>A synonymous_variant 0.2 rifampicin
rpoB 761955 p.Ile717Val missense_variant 0.2 rifampicin Uncertain significance
rpoB 761969 c.2163G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.19 rifampicin
rpoB 762038 c.2232C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762047 c.2241G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762056 c.2250G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.19 rifampicin Uncertain significance
rpoB 762122 c.2316C>T synonymous_variant 0.2 rifampicin
rpoB 762131 c.2325C>G synonymous_variant 0.16 rifampicin
rpoB 762134 c.2328C>A synonymous_variant 0.16 rifampicin
rpoB 762137 c.2331C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762140 c.2334G>C synonymous_variant 0.15 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.15 rifampicin
rpoB 762149 c.2343G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762158 c.2352G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762194 c.2388G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762236 c.2430G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762245 c.2439G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 762275 c.2469C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762296 c.2490G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762323 c.2517C>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 762398 c.-972T>C upstream_gene_variant 0.14 rifampicin
rpoB 762410 c.2604T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762416 c.2610A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762449 c.2643C>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762452 c.2646G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762470 c.2664G>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 762488 c.2682G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762491 c.2685T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 762509 c.-861T>G upstream_gene_variant 0.22 rifampicin
rpoB 762510 p.Ala902Pro missense_variant 0.23 rifampicin Uncertain significance
rpoB 762515 c.2709C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 762533 c.-837T>C upstream_gene_variant 0.15 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.15 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.15 rifampicin
rpoC 762551 c.-819C>T upstream_gene_variant 0.14 rifampicin
rpoB 762857 c.3051C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762860 c.3054G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762863 c.3057T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 762866 c.3060C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762879 p.Met1025Leu missense_variant 0.27 rifampicin Uncertain significance
rpoB 762894 c.3088C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762899 c.3093G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762917 c.3111C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 762959 c.3153G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762962 c.3156C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763082 c.3276C>T synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoB 763088 c.3282C>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 763094 c.3288G>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 763127 c.3321G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 763145 c.3339G>A synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 763157 c.3351G>T synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763172 c.3366G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763184 c.3378C>T synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoC 763402 c.33C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763408 c.39T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763411 c.42T>C synonymous_variant 0.2 rifampicin
rpoC 763414 c.45T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763415 p.Thr16Ser missense_variant 0.19 rifampicin Uncertain significance
rpoC 763423 p.Glu18Asp missense_variant 0.21 rifampicin Uncertain significance
rpoC 763430 c.61_63delAGGinsCGA synonymous_variant 0.24 rifampicin
rpoC 763433 p.Gln22Asn missense_variant 0.19 rifampicin
rpoC 763443 p.Tyr25Phe missense_variant 0.21 rifampicin
rpoC 763450 c.81G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763468 c.99G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763492 c.123G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 763657 c.288G>A synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763666 c.297G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763669 c.300C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763699 c.330G>T synonymous_variant 0.2 rifampicin
rpoC 763702 c.333C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>C synonymous_variant 0.18 rifampicin
rpoC 763711 c.342G>C synonymous_variant 0.17 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.19 rifampicin
rpoC 763732 c.363C>A synonymous_variant 0.18 rifampicin
rpoC 764040 p.Ser224Thr missense_variant 0.18 rifampicin
rpoC 764044 c.675T>C synonymous_variant 0.2 rifampicin
rpoC 764054 c.685C>T synonymous_variant 0.23 rifampicin
rpoC 764059 c.690G>T synonymous_variant 0.23 rifampicin
rpoC 764095 c.726C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764098 c.729A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 764110 c.741C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764143 c.774G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764147 p.Ser260Ala missense_variant 0.32 rifampicin Uncertain significance
rpoC 764150 p.Ile261Val missense_variant 0.29 rifampicin Uncertain significance
rpoC 764165 p.Glu266Gln missense_variant 0.29 rifampicin
rpoC 764176 c.807C>T synonymous_variant 0.28 rifampicin
rpoC 764177 p.Ile270Leu missense_variant 0.23 rifampicin
rpoC 764182 c.813C>T synonymous_variant 0.23 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Asn missense_variant 0.25 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.29 rifampicin
rpoC 764206 p.Asp279Glu missense_variant 0.27 rifampicin
rpoC 764207 p.Val280Thr missense_variant 0.29 rifampicin Uncertain significance
rpoC 764215 c.846A>C synonymous_variant 0.27 rifampicin
rpoC 764217 p.Asn283Ser missense_variant 0.26 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764428 c.1059G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764431 c.1062G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.29 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764461 c.1092A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 764470 c.1101C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764497 c.1128A>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764524 c.1155C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764530 c.1161C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764534 c.1165C>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 764542 c.1173C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764545 c.1176C>A synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764611 c.1242G>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764668 c.1299C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764692 c.1323C>T synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 764713 c.1344G>T synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764716 c.1347G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764746 c.1377G>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764758 c.1389C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764791 c.1422C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 764803 c.1434C>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.39 rifampicin Not assoc w R
rpoC 764810 p.Pro481Ala missense_variant 0.38 rifampicin Uncertain significance
rpoC 764815 c.1446A>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 764869 c.1500C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764875 c.1506C>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 764887 c.1518G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.26 rifampicin
rpoC 764912 p.Met515Gln missense_variant 0.26 rifampicin Uncertain significance
rpoC 764932 c.1563C>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579_1581delTTGinsCTC synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765040 c.1671T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765343 c.1974G>A synonymous_variant 0.23 rifampicin
rpoC 765352 c.1983G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765356 p.Met663Val missense_variant 0.22 rifampicin
rpoC 765370 c.2001G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765379 c.2010G>C synonymous_variant 0.2 rifampicin
rpoC 765382 c.2013G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.22 rifampicin Uncertain significance
rpoC 765403 c.2034G>C synonymous_variant 0.26 rifampicin
rpoC 765405 p.Leu679His missense_variant 0.27 rifampicin Uncertain significance
rpoC 765409 c.2040T>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 765421 c.2052C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 765449 p.Ala694Ser missense_variant 0.19 rifampicin Uncertain significance
rpoC 765469 c.2100G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>G synonymous_variant 0.14 rifampicin
rpoC 765875 p.Val836Ile missense_variant 0.18 rifampicin Uncertain significance
rpoC 765886 c.2517C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765907 c.2538G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765910 c.2541G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765940 c.2571A>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoC 767002 c.3633G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767008 c.3639G>A synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 767023 c.3654C>T synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 767044 c.3675G>C synonymous_variant 0.51 rifampicin Not assoc w R - Interim
rpoC 767080 c.3711G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoC 767098 c.3729T>C synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 767104 c.3735C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767107 c.3738C>T synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoC 767125 c.3756G>C synonymous_variant 0.38 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>T synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoC 767138 c.3769C>T synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 767149 c.3780C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 767158 c.3789T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 767179 c.3810C>T synonymous_variant 0.27 rifampicin
rpoC 767180 p.Ala1271Ser missense_variant 0.27 rifampicin Uncertain significance
rpoC 767191 c.3822C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767197 c.3828G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 767203 c.3834C>G synonymous_variant 0.23 rifampicin
rpoC 767206 c.3837C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.21 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.16 streptomycin
rpsL 781608 p.Ser17Gly missense_variant 0.16 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.18 streptomycin Not assoc w R - Interim
rpsL 781649 c.90T>C synonymous_variant 0.15 streptomycin
rpsL 781670 c.111G>C synonymous_variant 0.17 streptomycin
rpsL 781706 c.147T>C synonymous_variant 0.15 streptomycin
rpsL 781715 c.156T>G synonymous_variant 0.16 streptomycin
rpsL 781721 c.162C>T synonymous_variant 0.14 streptomycin
rpsL 781725 p.Lys56Arg missense_variant 0.15 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.15 streptomycin
rpsL 781733 c.174G>C synonymous_variant 0.15 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.15 streptomycin
rpsL 781737 p.Gln60Ala missense_variant 0.14 streptomycin
rpsL 781742 c.183C>G synonymous_variant 0.14 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.14 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.14 streptomycin
rpsL 781763 c.204C>G synonymous_variant 0.15 streptomycin
rpsL 781766 c.207C>T synonymous_variant 0.14 streptomycin Not assoc w R - Interim
rpsL 781772 c.213C>T synonymous_variant 0.18 streptomycin Not assoc w R - Interim
rpsL 781802 c.243G>C synonymous_variant 0.32 streptomycin
rpsL 781814 c.255C>T synonymous_variant 0.33 streptomycin
rpsL 781817 c.258G>T synonymous_variant 0.35 streptomycin
rpsL 781829 c.270G>C synonymous_variant 0.31 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.33 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.42 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.38 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.38 streptomycin
rpsL 781877 c.318T>A synonymous_variant 0.37 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.36 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.36 streptomycin
rpsL 781907 c.348T>C synonymous_variant 0.36 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.34 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.27 streptomycin Uncertain significance
rpsL 781933 c.374G>A splice_region_variant&stop_retained_variant 0.26 streptomycin
rplC 800204 c.-605T>C upstream_gene_variant 1.0 linezolid
atpE 1461132 p.Val30Ile missense_variant 0.31 bedaquiline
atpE 1461146 c.102G>T synonymous_variant 0.29 bedaquiline
atpE 1461149 c.105T>G synonymous_variant 0.28 bedaquiline
atpE 1461161 c.117C>G synonymous_variant 0.28 bedaquiline
atpE 1461164 c.120C>T synonymous_variant 0.27 bedaquiline
atpE 1461167 c.123G>T synonymous_variant 0.26 bedaquiline
atpE 1461170 c.126A>G synonymous_variant 0.26 bedaquiline
atpE 1461179 c.135G>T synonymous_variant 0.24 bedaquiline
atpE 1461182 c.138A>G synonymous_variant 0.23 bedaquiline
atpE 1461185 c.141G>C synonymous_variant 0.23 bedaquiline
atpE 1461197 c.153A>C synonymous_variant 0.22 bedaquiline
atpE 1461219 c.175T>C synonymous_variant 0.2 bedaquiline
rrs 1471615 n.-231C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471922 n.78delT non_coding_transcript_exon_variant 0.3 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471925 n.80T>C non_coding_transcript_exon_variant 0.33 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1471931 n.87delA non_coding_transcript_exon_variant 0.28 kanamycin
capreomycin
streptomycin
amikacin
rrs 1471934 n.89A>G non_coding_transcript_exon_variant 0.31 kanamycin
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471985 n.140T>C non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472031 n.186G>C non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472032 n.187G>A non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472033 n.188A>C non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472035 n.190G>T non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472040 n.195T>G non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472041 n.196C>T non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472042 n.197T>G non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472043 n.198T>A non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472050 n.205G>C non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472053 n.211_212delGC non_coding_transcript_exon_variant 0.41 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.44 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472106 n.261G>A non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.47 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472380 n.535G>C non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.83 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.77 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.83 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472846 n.1001C>T non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472847 n.1002G>A non_coding_transcript_exon_variant 0.5 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472848 n.1003T>C non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472860 n.1015C>T non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472861 n.1016G>A non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.75 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.82 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472989 n.1144G>A non_coding_transcript_exon_variant 0.81 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.81 kanamycin Not assoc w R
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473082 n.1237G>A non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.7 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.8 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.67 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.77 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.62 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.76 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473129 n.1284C>T non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.58 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473288 n.1443C>T non_coding_transcript_exon_variant 0.51 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.53 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1473829 n.172G>C non_coding_transcript_exon_variant 0.82 capreomycin Uncertain significance
linezolid
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 1.0 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475129 n.1472G>A non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475760 n.2105_2106delGC non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475764 n.2107A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1475765 n.2108A>T non_coding_transcript_exon_variant 1.0 capreomycin
linezolid
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.5 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.54 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.59 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.65 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.6 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.42 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.72 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476665 n.3008T>A non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid
rrl 1476674 n.3017T>C non_coding_transcript_exon_variant 0.42 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833547 c.6G>A synonymous_variant 0.15 pyrazinamide
rpsA 1833589 c.48A>C synonymous_variant 0.16 pyrazinamide
rpsA 1833595 c.54T>G synonymous_variant 0.17 pyrazinamide
rpsA 1833596 p.Ser19Ala missense_variant 0.18 pyrazinamide
rpsA 1833604 c.63C>T synonymous_variant 0.19 pyrazinamide
rpsA 1833616 c.75A>T synonymous_variant 0.17 pyrazinamide
rpsA 1833619 c.78A>C synonymous_variant 0.23 pyrazinamide
rpsA 1833664 c.123C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833676 c.135A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833679 c.138G>T synonymous_variant 0.27 pyrazinamide
rpsA 1833685 c.144G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833691 c.150G>A synonymous_variant 0.19 pyrazinamide
rpsA 1833694 c.153G>T synonymous_variant 0.2 pyrazinamide
rpsA 1833697 c.156C>T synonymous_variant 0.21 pyrazinamide
rpsA 1833700 c.159C>T synonymous_variant 0.2 pyrazinamide
rpsA 1833709 c.168C>T synonymous_variant 0.29 pyrazinamide
rpsA 1833724 c.183C>T synonymous_variant 0.27 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.27 pyrazinamide
rpsA 1833733 c.192C>G synonymous_variant 0.19 pyrazinamide
rpsA 1833734 p.Ala65Ser missense_variant 0.2 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.24 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.2 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.2 pyrazinamide
rpsA 1833760 c.219C>T synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
rpsA 1833787 c.246C>G synonymous_variant 0.29 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.31 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.32 pyrazinamide
rpsA 1833823 c.282G>A synonymous_variant 0.33 pyrazinamide
rpsA 1833832 c.291G>A synonymous_variant 0.32 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.33 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.35 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.35 pyrazinamide
rpsA 1833862 c.321G>T synonymous_variant 0.31 pyrazinamide
rpsA 1833874 c.333T>G synonymous_variant 0.34 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.33 pyrazinamide
rpsA 1833894 p.Ala118Glu missense_variant 0.34 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.37 pyrazinamide
rpsA 1833949 c.408T>C synonymous_variant 0.32 pyrazinamide
rpsA 1833961 c.420C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833970 c.429G>T synonymous_variant 0.23 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.28 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.26 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834009 c.468C>T synonymous_variant 0.22 pyrazinamide
rpsA 1834012 c.471G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834015 c.474G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834033 c.492C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834228 c.687C>A synonymous_variant 0.19 pyrazinamide
rpsA 1834231 c.690T>G synonymous_variant 0.19 pyrazinamide
rpsA 1834234 c.693G>T synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834240 c.699T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834246 c.705G>T synonymous_variant 0.22 pyrazinamide
rpsA 1834249 c.708T>C synonymous_variant 0.25 pyrazinamide
rpsA 1834252 c.711C>G synonymous_variant 0.23 pyrazinamide
rpsA 1834261 c.720A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
rpsA 1834264 c.723G>C synonymous_variant 0.27 pyrazinamide
rpsA 1834279 c.738C>T synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
rpsA 1834294 c.753G>T synonymous_variant 0.33 pyrazinamide
rpsA 1834297 c.756C>T synonymous_variant 0.35 pyrazinamide
rpsA 1834303 c.762T>G synonymous_variant 0.33 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.34 pyrazinamide
rpsA 1834327 c.786G>T synonymous_variant 0.31 pyrazinamide
rpsA 1834357 c.816T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834366 c.825A>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
rpsA 1834375 c.834G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834396 c.855G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834411 c.870T>G synonymous_variant 0.19 pyrazinamide
rpsA 1834414 c.873C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.16 pyrazinamide
rpsA 1834420 c.879C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834429 c.888C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834438 c.897C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
rpsA 1834451 c.910T>C synonymous_variant 0.29 pyrazinamide
rpsA 1834456 c.915T>G synonymous_variant 0.25 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834477 c.936C>T synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1834489 c.948T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834519 c.978G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834520 p.Ala327Ser missense_variant 0.15 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834534 c.993C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834606 c.1065C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834645 c.1104C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834667 p.Ala376Ser missense_variant 0.18 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.21 pyrazinamide
rpsA 1834700 p.Gln387Ala missense_variant 0.22 pyrazinamide
rpsA 1834705 c.1164C>G synonymous_variant 0.19 pyrazinamide
rpsA 1834720 c.1179C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834759 c.1218A>C synonymous_variant 0.17 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.16 pyrazinamide
rpsA 1834774 c.1233C>T synonymous_variant 0.18 pyrazinamide
rpsA 1834776 p.Ala412Glu missense_variant 0.18 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.18 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.15 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2063685 c.1044G>A synonymous_variant 1.0 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R
streptomycin Not assoc w R - Interim
amikacin Not assoc w R
bacA 2063911 p.Ile273Thr missense_variant 1.0 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
PPE35 2169879 p.Phe245Cys missense_variant 1.0 pyrazinamide Uncertain significance
PPE35 2170933 c.-321G>A upstream_gene_variant 1.0 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2517917 c.-198G>C upstream_gene_variant 0.29 isoniazid
kasA 2517941 c.-174C>G upstream_gene_variant 0.31 isoniazid
kasA 2517953 c.-162C>T upstream_gene_variant 0.26 isoniazid
kasA 2517962 c.-153C>G upstream_gene_variant 0.24 isoniazid
kasA 2517968 c.-147T>A upstream_gene_variant 0.2 isoniazid
kasA 2518756 c.642G>C synonymous_variant 0.18 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.14 isoniazid
ald 3086742 c.-78A>C upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
lpqB 3623222 c.1689A>G synonymous_variant 1.0 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 1.0 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625656 c.958T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3625705 c.909C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625708 c.906C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625711 c.903C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625720 c.894G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625729 c.885A>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625732 c.882C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625735 c.879C>A synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625744 c.870G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625750 c.864G>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.31 rifampicin Uncertain significance
bedaquiline
mtrB 3625761 p.Gln285Glu missense_variant 0.28 rifampicin Uncertain significance
bedaquiline
mtrB 3625762 c.852A>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625765 c.849C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.31 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3625783 c.-873C>T upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrB 3625806 c.808A>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625807 c.807C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625813 c.801C>T synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
mtrB 3625819 p.Glu265Val missense_variant 0.32 rifampicin Uncertain significance
bedaquiline
mtrB 3625837 c.777C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625855 c.759G>A synonymous_variant 0.28 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625867 c.747A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626681 c.-68C>T upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3626684 c.-71G>A upstream_gene_variant 0.21 rifampicin
bedaquiline
mtrB 3626704 c.-91C>T upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626711 c.-98T>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3626717 c.-104C>T upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrB 3626726 c.-113T>C upstream_gene_variant 0.28 rifampicin
bedaquiline
mtrB 3626732 c.-119A>G upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrA 3626741 c.609C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626756 c.594C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626759 c.591T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626762 c.588G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626786 c.564A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626792 c.558G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626804 c.546A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3626825 c.525T>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627104 c.-491C>T upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3627128 c.-515T>C upstream_gene_variant 0.13 rifampicin
bedaquiline
mtrA 3627133 p.Ala73Ser missense_variant 0.13 rifampicin
bedaquiline
mtrB 3627139 c.-526T>C upstream_gene_variant 0.15 rifampicin
bedaquiline
mtrB 3627143 c.-530G>C upstream_gene_variant 0.13 rifampicin
bedaquiline
mtrB 3627149 c.-536G>A upstream_gene_variant 0.14 rifampicin
bedaquiline
rpoA 3877554 c.954G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877560 c.948C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877569 p.Pro313Thr missense_variant 0.2 rifampicin Uncertain significance
rpoA 3877587 c.921A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877593 c.915C>T synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877614 c.894G>A synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877620 c.888G>A synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877638 c.870T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877656 c.852T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877665 c.843C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877677 c.831G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877680 c.828G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877836 c.672A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>A synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877856 c.652T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877872 c.636C>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877908 c.600T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877920 c.588G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877929 p.Ile193Val missense_variant 0.29 rifampicin Uncertain significance
rpoA 3877962 c.546G>T synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877971 p.Asp179Glu missense_variant 0.22 rifampicin Uncertain significance
rpoA 3877974 c.534G>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877977 p.Lys177Asn missense_variant 0.22 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878163 c.345C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3878259 c.249G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.21 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878301 c.207C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878310 c.198G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878313 c.195G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
clpC1 4038767 c.1938G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.16 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038782 c.1923G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038795 p.Ser637Thr missense_variant 0.21 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.19 pyrazinamide
clpC1 4038838 c.1867C>T synonymous_variant 0.19 pyrazinamide
clpC1 4038845 c.1858_1860delTCGinsAGC synonymous_variant 0.18 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.18 pyrazinamide
clpC1 4038911 c.1794G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038914 c.1791G>T synonymous_variant 0.15 pyrazinamide
clpC1 4038923 c.1782A>T synonymous_variant 0.15 pyrazinamide
clpC1 4038928 c.1777C>A synonymous_variant 0.16 pyrazinamide
clpC1 4038929 c.1776G>A synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038932 c.1773G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038941 c.1764G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.22 pyrazinamide
clpC1 4039046 c.1659C>G synonymous_variant 0.29 pyrazinamide
clpC1 4039070 c.1635G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039077 p.Lys543Arg missense_variant 0.22 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039091 c.1614G>T synonymous_variant 0.28 pyrazinamide
clpC1 4039097 c.1608G>T synonymous_variant 0.3 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.32 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.36 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.29 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.27 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039190 c.1515C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039196 c.1509G>A synonymous_variant 0.21 pyrazinamide
clpC1 4039199 p.Ala502Glu missense_variant 0.2 pyrazinamide
clpC1 4039208 c.1497C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039220 c.1485G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039262 c.1443C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039382 c.1323C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039391 c.1314T>C synonymous_variant 0.31 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.28 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.31 pyrazinamide Uncertain significance
clpC1 4039418 c.1287C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.41 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.36 pyrazinamide Not assoc w R - Interim
clpC1 4039466 c.1239T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.41 pyrazinamide
clpC1 4039472 c.1233G>C synonymous_variant 0.38 pyrazinamide
clpC1 4039478 c.1227G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.38 pyrazinamide
clpC1 4039487 c.1218G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039522 c.1183C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039528 c.1177C>A synonymous_variant 0.27 pyrazinamide
clpC1 4039541 c.1164C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039544 c.1161C>T synonymous_variant 0.25 pyrazinamide
clpC1 4039559 c.1146C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039565 c.1140G>T synonymous_variant 0.2 pyrazinamide
clpC1 4039570 p.Met379Leu missense_variant 0.2 pyrazinamide Uncertain significance
clpC1 4039571 c.1134G>A synonymous_variant 0.2 pyrazinamide
clpC1 4039574 p.Ala377Gly missense_variant 0.2 pyrazinamide
clpC1 4039586 c.1119G>C synonymous_variant 0.23 pyrazinamide
clpC1 4039601 c.1104G>A synonymous_variant 0.24 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039619 c.1086G>A synonymous_variant 0.21 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.21 pyrazinamide
clpC1 4039649 c.1056G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039661 c.1044T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.24 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.31 pyrazinamide
clpC1 4039733 c.972G>A synonymous_variant 0.31 pyrazinamide
clpC1 4039739 c.966C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.31 pyrazinamide
clpC1 4039748 c.957G>C synonymous_variant 0.3 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.29 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.3 pyrazinamide
clpC1 4039760 c.945T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039763 c.942C>T synonymous_variant 0.32 pyrazinamide Not assoc w R - Interim
clpC1 4039769 c.936C>G synonymous_variant 0.33 pyrazinamide
clpC1 4039778 c.927A>G synonymous_variant 0.33 pyrazinamide
clpC1 4039793 c.912C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039814 c.891C>G synonymous_variant 0.34 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.29 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.28 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039832 c.873C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039868 c.837C>T synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039913 c.792C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.3 pyrazinamide
clpC1 4039934 c.771G>C synonymous_variant 0.28 pyrazinamide
clpC1 4039943 c.762G>C synonymous_variant 0.26 pyrazinamide
clpC1 4039946 c.759A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.25 pyrazinamide
clpC1 4039957 c.748C>T synonymous_variant 0.27 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.27 pyrazinamide
clpC1 4039964 c.741C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039975 p.Asp244Asn missense_variant 0.34 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.35 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.35 pyrazinamide Not assoc w R - Interim
clpC1 4040009 c.696C>G synonymous_variant 0.37 pyrazinamide
clpC1 4040015 c.690G>C synonymous_variant 0.33 pyrazinamide
clpC1 4040021 c.684A>T synonymous_variant 0.29 pyrazinamide
clpC1 4040024 c.681A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.27 pyrazinamide
clpC1 4040048 c.657C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040087 c.618G>C synonymous_variant 0.14 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.14 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040309 c.396C>T synonymous_variant 0.2 pyrazinamide
clpC1 4040333 c.372G>C synonymous_variant 0.21 pyrazinamide
clpC1 4040342 c.363C>A synonymous_variant 0.23 pyrazinamide
clpC1 4040348 c.357G>T synonymous_variant 0.22 pyrazinamide
clpC1 4040354 c.351A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040357 c.348T>C synonymous_variant 0.24 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.22 pyrazinamide
clpC1 4040366 c.339C>T synonymous_variant 0.19 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.19 pyrazinamide
clpC1 4040375 c.330G>C synonymous_variant 0.19 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.18 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040423 c.282A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040426 c.279T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040431 c.274T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040441 c.264C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
panD 4044138 c.144T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
panD 4044150 c.132A>C synonymous_variant 0.18 pyrazinamide
panD 4044156 c.126A>G synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
panD 4044167 c.115C>T synonymous_variant 0.18 pyrazinamide
panD 4044171 c.111C>T synonymous_variant 0.17 pyrazinamide
panD 4044174 c.108C>T synonymous_variant 0.18 pyrazinamide
panD 4044180 p.Asp34Glu missense_variant 0.19 pyrazinamide
panD 4044186 c.94_96delTTGinsCTC synonymous_variant 0.18 pyrazinamide
panD 4044189 c.93C>T synonymous_variant 0.18 pyrazinamide
panD 4044194 p.Ala30Pro missense_variant 0.2 pyrazinamide
panD 4044195 c.87T>C synonymous_variant 0.2 pyrazinamide
glpK 4138664 c.1092G>C synonymous_variant 0.13 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240819 c.957A>C synonymous_variant 0.16 ethambutol
embC 4240826 p.Ala322Ser missense_variant 0.21 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.2 ethambutol
embC 4240859 p.Leu333Met missense_variant 0.15 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4249594 c.3081G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
ethA 4328376 c.-903G>C upstream_gene_variant 1.0 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin