TB-Profiler result

Run: ERR502912
Summary

Run ID: ERR502912

Sample name:

Date: 2024-04-14T16:40:37.522716

Number of reads: 2489005

Percentage reads mapped: 73.48

Median coverage: 51.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.99
La1.2.BCG M.bovis None 0.06
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.98
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin tlyA c.319_321delCACinsGA Assoc w R
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.859_861delATCinsGG Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiA c.358_360delCAGinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303789 c.859_861delATCinsGG frameshift_variant&missense_variant 0.18 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.21 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
tlyA 1918258 c.319_321delCACinsGA frameshift_variant&missense_variant 0.22 capreomycin Assoc w R
fbiA 3640900 c.358_360delCAGinsAC frameshift_variant&missense_variant 0.18 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
embB 4247448 p.His312Arg missense_variant 0.25 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 756 c.756T>C synonymous_variant 0.16 isoniazid
dnaA 777 c.777A>G synonymous_variant 0.17 isoniazid
dnaA 786 c.786C>T synonymous_variant 0.15 isoniazid
gyrB 6250 c.1011A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6256 c.1017G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6268 c.1029C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6280 c.1041T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrB 6289 c.1050C>T synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7763 c.462T>C synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7775 c.474C>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8135 c.834C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8340 p.Ala347Ser missense_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8372 c.1071G>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8375 c.1074G>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 8382 p.Leu361Met missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 8387 c.1086C>T synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8391 c.1090_1092delTATinsCC frameshift_variant&missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 8399 c.1098T>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8401 p.Asp367Ala missense_variant 0.17 levofloxacin
moxifloxacin
gyrA 8405 c.1104C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8420 c.1119T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8442 c.1141C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8636 c.1335A>C synonymous_variant 0.17 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8642 c.1341A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8672 c.1371A>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8870 c.1569G>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8873 c.1572A>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8897 c.1596T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8903 c.1602T>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8918 c.1617C>A synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 8933 c.1632G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 9119 c.1818A>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9122 c.1821C>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.21 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9152 c.1851C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9153 p.Thr618Glu missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 9158 c.1857C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9161 c.1860C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9182 c.1881T>C synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9191 c.1890G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9200 c.1899A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9204 p.Ser635Thr missense_variant 0.21 levofloxacin
moxifloxacin
gyrA 9224 c.1923C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9230 c.1929T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9233 c.1932C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9239 c.1938C>T synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9252 p.Val651Ile missense_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9284 c.1983T>C synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 9291 c.1990C>T synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9296 c.1995T>C synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9299 c.1998G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9300 p.Ala667Ser missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9308 p.Asp669Glu missense_variant 0.19 levofloxacin
moxifloxacin
gyrA 9323 c.2022C>G synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9335 c.2034G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9666 p.Arg789Gly missense_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9674 c.2373T>C synonymous_variant 0.25 levofloxacin
moxifloxacin
gyrA 9704 c.2403T>G synonymous_variant 0.19 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9716 c.2415T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9725 c.2424G>A synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 9727 p.Gly809Glu missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9729 p.Asp810Asn missense_variant 0.16 levofloxacin
moxifloxacin
gyrA 9734 c.2433A>C synonymous_variant 0.17 levofloxacin
moxifloxacin
fgd1 490812 c.30A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 490815 c.33G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 490827 c.45C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 490848 c.66A>G synonymous_variant 0.28 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fgd1 490851 c.69A>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 490868 p.Ala29Gly missense_variant 0.33 clofazimine
pretomanid
delamanid
fgd1 490887 c.105G>A synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fgd1 490890 c.108C>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fgd1 490896 c.114C>T synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fgd1 490905 c.123T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fgd1 490911 c.129T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fgd1 490917 c.135C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575084 c.-264T>C upstream_gene_variant 0.18 ethionamide
isoniazid
mshA 575527 c.180G>C synonymous_variant 0.15 ethionamide
isoniazid
mshA 575536 c.189T>C synonymous_variant 0.22 ethionamide
isoniazid
mshA 575542 c.195C>A synonymous_variant 0.22 ethionamide
isoniazid
mshA 575561 p.Met72Val missense_variant 0.21 ethionamide
isoniazid
mshA 575569 c.222A>G synonymous_variant 0.21 ethionamide
isoniazid
mshA 575571 p.Ser75Thr missense_variant 0.21 ethionamide
isoniazid
mshA 575576 c.229C>T synonymous_variant 0.22 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575581 c.234C>T synonymous_variant 0.21 ethionamide
isoniazid
mshA 575587 c.240C>G synonymous_variant 0.23 ethionamide
isoniazid
mshA 575590 c.243T>C synonymous_variant 0.25 ethionamide
isoniazid
mshA 575623 c.276C>G synonymous_variant 0.17 ethionamide
isoniazid
mshA 575674 c.327G>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.22 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.27 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.32 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.34 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.35 ethionamide
isoniazid
mshA 575749 c.402C>A synonymous_variant 0.3 ethionamide
isoniazid
mshA 575752 c.405G>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575755 c.408G>A synonymous_variant 0.27 ethionamide
isoniazid
mshA 575756 c.409C>T synonymous_variant 0.27 ethionamide
isoniazid
mshA 575770 c.423G>A synonymous_variant 0.28 ethionamide
isoniazid
mshA 575771 p.Val142Ser missense_variant 0.27 ethionamide
isoniazid
mshA 575779 c.432A>G synonymous_variant 0.26 ethionamide
isoniazid
mshA 575782 c.435G>C synonymous_variant 0.27 ethionamide
isoniazid
mshA 575809 c.462C>T synonymous_variant 0.24 ethionamide
isoniazid
mshA 575812 c.465C>T synonymous_variant 0.21 ethionamide
isoniazid
ccsA 619570 c.-321G>C upstream_gene_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 619574 c.-317G>A upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 619579 c.-312G>C upstream_gene_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 619584 c.-307A>T upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 619591 c.-300G>C upstream_gene_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 619609 c.-282G>C upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619634 c.-257T>A upstream_gene_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 619645 c.-246G>C upstream_gene_variant 0.25 capreomycin
amikacin
kanamycin
ccsA 619654 c.-237A>G upstream_gene_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620254 c.364_366delCTCinsTG frameshift_variant&missense_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620265 c.375C>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620268 c.378G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620412 c.522T>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620415 c.525T>C synonymous_variant 0.18 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620421 c.531G>C synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620424 c.534G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620433 c.543C>G synonymous_variant 0.18 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620436 c.546T>A synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620439 c.549T>C synonymous_variant 0.17 capreomycin
amikacin
kanamycin
ccsA 620445 c.555A>G synonymous_variant 0.18 capreomycin
amikacin
kanamycin
ccsA 620682 c.792G>A synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620688 c.798G>C synonymous_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAA frameshift_variant&missense_variant 0.28 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.26 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620763 c.873G>A synonymous_variant 0.24 capreomycin
amikacin
kanamycin
ccsA 620769 c.879C>G synonymous_variant 0.23 capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
ccsA 620778 c.888T>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
Rv0565c 656265 c.1206G>C synonymous_variant 0.17 ethionamide
Rv0565c 656268 p.Met401Ile missense_variant 0.16 ethionamide
Rv0565c 657081 c.390G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 1.0 ethionamide Uncertain significance
Rv0565c 657300 c.171C>G synonymous_variant 0.18 ethionamide
Rv0565c 657318 c.153T>C synonymous_variant 0.18 ethionamide
Rv0565c 657324 c.147C>G synonymous_variant 0.18 ethionamide
Rv0565c 657337 p.Arg45Gln missense_variant 0.2 ethionamide Uncertain significance
Rv0565c 657342 c.129T>C synonymous_variant 0.19 ethionamide
Rv0565c 657347 c.124A>C synonymous_variant 0.19 ethionamide
Rv0565c 657348 c.123A>G synonymous_variant 0.2 ethionamide
Rv0565c 657356 p.Ile39Val missense_variant 0.23 ethionamide
Rv0565c 657372 c.99G>C synonymous_variant 0.17 ethionamide
Rv0565c 657632 c.-162G>A upstream_gene_variant 0.32 ethionamide
Rv0565c 657649 c.-179G>A upstream_gene_variant 0.37 ethionamide
Rv0565c 657671 c.-201A>G upstream_gene_variant 0.39 ethionamide
Rv0565c 657678 c.-209_-208delAAinsTC upstream_gene_variant 0.38 ethionamide
Rv0565c 657689 c.-220_-219delCAinsAC upstream_gene_variant 0.38 ethionamide
Rv0565c 657701 c.-231C>G upstream_gene_variant 0.4 ethionamide
Rv0565c 657734 c.-264T>C upstream_gene_variant 0.26 ethionamide
hadA 732295 c.366G>C synonymous_variant 0.2 isoniazid
hadA 732305 p.Ile126Val missense_variant 0.2 isoniazid
hadA 732308 p.Val127Ile missense_variant 0.2 isoniazid
hadA 732321 p.Glu131Ala missense_variant 0.22 isoniazid
hadA 732329 p.Leu134Val missense_variant 0.23 isoniazid Uncertain significance
hadA 732337 c.408G>A synonymous_variant 0.24 isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.24 isoniazid
hadA 732396 p.Gly156Ala missense_variant 0.26 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.24 isoniazid
nusG 734407 c.154_156delGTTinsAC frameshift_variant&missense_variant 0.21 rifampicin
nusG 734421 c.168A>G synonymous_variant 0.24 rifampicin
nusG 734424 c.171G>A synonymous_variant 0.27 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.28 rifampicin
nusG 734451 c.198G>C synonymous_variant 0.26 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.27 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.3 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
nusG 734499 c.246G>C synonymous_variant 0.32 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734541 c.288A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
nusG 734556 c.303C>T synonymous_variant 0.29 rifampicin
nusG 734559 c.306T>C synonymous_variant 0.3 rifampicin
nusG 734580 c.327T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
nusG 734589 c.336G>C synonymous_variant 0.27 rifampicin
nusG 734596 c.343T>C synonymous_variant 0.28 rifampicin
nusG 734601 c.348C>G synonymous_variant 0.23 rifampicin
nusG 734610 c.357C>G synonymous_variant 0.19 rifampicin
nusG 734826 c.573A>C synonymous_variant 0.18 rifampicin
nusG 734829 c.576C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
nusG 734841 c.588G>C synonymous_variant 0.23 rifampicin
nusG 734847 c.594T>C synonymous_variant 0.21 rifampicin
nusG 734850 c.597C>G synonymous_variant 0.22 rifampicin
nusG 734853 c.600A>G synonymous_variant 0.21 rifampicin
nusG 734854 c.601T>C synonymous_variant 0.21 rifampicin
nusG 734882 p.Ala210Gly missense_variant 0.21 rifampicin
nusG 734886 c.633A>G synonymous_variant 0.2 rifampicin
rpoB 760067 c.261G>C synonymous_variant 0.19 rifampicin
rpoB 760070 c.264T>G synonymous_variant 0.19 rifampicin
rpoB 760091 c.285G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760101 c.295T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760112 c.306T>C synonymous_variant 0.25 rifampicin
rpoB 760118 c.312T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760121 c.315T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760130 p.Asp108Glu missense_variant 0.29 rifampicin Uncertain significance
rpoB 760139 c.333A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 760142 c.336C>G synonymous_variant 0.32 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.29 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.31 rifampicin
rpoB 760310 c.504G>C synonymous_variant 0.32 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.27 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.27 rifampicin
rpoB 760340 c.534G>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.29 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.25 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.24 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.23 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.21 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.19 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.17 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.19 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.21 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 760670 c.864G>C synonymous_variant 0.27 rifampicin
rpoB 760674 c.868T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760715 c.909C>G synonymous_variant 0.18 rifampicin
rpoB 760718 c.912C>T synonymous_variant 0.17 rifampicin
rpoB 760724 c.918T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 760730 c.924T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760826 c.1020C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760841 c.1035T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760845 p.Thr347Pro missense_variant 0.19 rifampicin
rpoB 760859 c.1053T>C synonymous_variant 0.25 rifampicin
rpoB 760862 c.1056G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760869 p.Val355Ile missense_variant 0.3 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.33 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.41 rifampicin
rpoB 760928 c.1122G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760931 c.1125C>G synonymous_variant 0.41 rifampicin
rpoB 760934 c.1128C>T synonymous_variant 0.43 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 760985 c.1179G>C synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.35 rifampicin
rpoB 761006 c.1200C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.33 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761057 c.1251G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 761102 c.1296A>G synonymous_variant 0.42 rifampicin
rpoB 761129 c.1323G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.31 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.33 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.34 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761306 c.1500C>G synonymous_variant 0.27 rifampicin
rpoB 761327 c.1521A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761330 c.1524G>C synonymous_variant 0.23 rifampicin
rpoB 761354 c.1548C>T synonymous_variant 0.22 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.2 rifampicin
rpoB 761373 p.Val523His missense_variant 0.18 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.17 rifampicin
rpoB 761510 c.1704T>C synonymous_variant 0.21 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.34 rifampicin
rpoB 761537 c.1731C>G synonymous_variant 0.37 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.42 rifampicin Not assoc w R - Interim
rpoB 761588 c.1782C>T synonymous_variant 0.43 rifampicin
rpoB 761606 c.1800C>G synonymous_variant 0.47 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoB 761645 c.1839C>G synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 761648 c.1842T>C synonymous_variant 0.4 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoB 761675 c.1869G>C synonymous_variant 0.28 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.16 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.19 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.19 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.24 rifampicin
rpoB 761791 p.Arg662His missense_variant 0.3 rifampicin
rpoB 761813 c.2007T>C synonymous_variant 0.31 rifampicin
rpoB 761815 p.Ala670Glu missense_variant 0.31 rifampicin
rpoB 761834 c.2028T>C synonymous_variant 0.35 rifampicin
rpoB 761848 p.Cys681Ser missense_variant 0.31 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.31 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.36 rifampicin
rpoB 761873 c.2067A>C synonymous_variant 0.39 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.3 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.3 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.29 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.29 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.29 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.29 rifampicin
rpoB 761948 c.2142G>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 761954 c.2148C>G synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762008 c.2202C>T synonymous_variant 0.44 rifampicin Not assoc w R - Interim
rpoB 762014 c.2208C>T synonymous_variant 0.45 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoB 762053 c.2247T>C synonymous_variant 0.4 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.3 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.29 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.3 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.29 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762206 c.2400C>G synonymous_variant 0.35 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.35 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.32 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.32 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.31 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 762314 c.2508C>T synonymous_variant 0.24 rifampicin
rpoB 762317 c.2511A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.2 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.21 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.17 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.17 rifampicin
rpoB 762449 c.2643C>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 762467 c.-903C>T upstream_gene_variant 0.16 rifampicin
rpoB 762488 c.2682G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 762489 p.Val895Gln missense_variant 0.2 rifampicin
rpoC 762509 c.-861T>G upstream_gene_variant 0.2 rifampicin
rpoB 762510 c.2704_2706delGCCinsCG frameshift_variant&missense_variant 0.2 rifampicin
rpoC 762521 c.-849C>T upstream_gene_variant 0.22 rifampicin
rpoC 762533 c.-837T>C upstream_gene_variant 0.18 rifampicin
rpoC 762536 c.-834T>C upstream_gene_variant 0.18 rifampicin
rpoC 762537 c.-833T>C upstream_gene_variant 0.17 rifampicin
rpoC 762551 c.-819C>G upstream_gene_variant 0.15 rifampicin
rpoB 762929 c.3123G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.18 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.16 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763085 c.3279C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763158 c.-212C>T upstream_gene_variant 0.15 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763486 c.117T>G synonymous_variant 0.19 rifampicin
rpoC 763492 c.123G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.2 rifampicin
rpoC 763657 c.288G>A synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763660 c.291T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.23 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.23 rifampicin
rpoC 763738 c.369G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763741 c.372C>T synonymous_variant 0.24 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.26 rifampicin
rpoC 763765 c.396T>C synonymous_variant 0.28 rifampicin
rpoC 763774 c.405G>C synonymous_variant 0.27 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763816 c.447C>G synonymous_variant 0.18 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.16 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.16 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.17 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.19 rifampicin
rpoC 763876 p.Glu169Asp missense_variant 0.19 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.23 rifampicin
rpoC 763888 c.519G>C synonymous_variant 0.24 rifampicin
rpoC 763891 c.522G>C synonymous_variant 0.23 rifampicin
rpoC 763894 c.525A>G synonymous_variant 0.22 rifampicin
rpoC 763900 c.531G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763945 c.576T>C synonymous_variant 0.18 rifampicin
rpoC 763951 c.582G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763960 c.591T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764206 c.837T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764215 c.846A>G synonymous_variant 0.18 rifampicin
rpoC 764236 c.867G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764248 c.879C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.18 rifampicin
rpoC 764266 c.897T>C synonymous_variant 0.16 rifampicin
rpoC 764278 c.909A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764338 c.969G>A synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.18 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>C synonymous_variant 0.17 rifampicin
rpoC 764651 c.1282_1284delTCGinsAGC synonymous_variant 0.17 rifampicin
rpoC 764752 c.1383G>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.29 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.2 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764948 c.1579T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.16 rifampicin
rpoC 765047 c.1678T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765055 c.1686C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765319 c.1950A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765330 p.Ser654Asn missense_variant 0.16 rifampicin Uncertain significance
rpoC 765346 c.1977C>G synonymous_variant 0.2 rifampicin
rpoC 765349 c.1980T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765352 c.1983G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765383 p.Met672Leu missense_variant 0.25 rifampicin Uncertain significance
rpoC 765404 p.Leu679Val missense_variant 0.19 rifampicin
rpoC 765409 c.2040T>C synonymous_variant 0.2 rifampicin
rpoC 765421 c.2052C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765451 c.2082C>A synonymous_variant 0.21 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.24 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.22 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.23 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.21 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.15 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.16 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.15 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.15 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.15 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.14 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.25 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.25 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765937 c.2568T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765947 c.2578T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.25 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.22 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.23 rifampicin
rpoC 766027 c.2658G>C synonymous_variant 0.28 rifampicin
rpoC 766043 p.Gln892Glu missense_variant 0.31 rifampicin
rpoC 766054 c.2685C>G synonymous_variant 0.28 rifampicin
rpoC 766082 p.Ala905Gln missense_variant 0.29 rifampicin
rpoC 766096 c.2727G>C synonymous_variant 0.34 rifampicin
rpoC 766129 c.2760C>G synonymous_variant 0.26 rifampicin
rpoC 766135 c.2766G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766141 c.2772C>T synonymous_variant 0.18 rifampicin
rpoC 766142 c.2773C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766408 c.3039C>G synonymous_variant 0.19 rifampicin
rpoC 766411 c.3042C>G synonymous_variant 0.19 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.2 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.19 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.23 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.26 rifampicin
rpoC 766484 c.3115_3117delGTAinsAC frameshift_variant&missense_variant 0.26 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.29 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.33 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.34 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.38 rifampicin
rpoC 766573 c.3204T>C synonymous_variant 0.37 rifampicin
rpoC 766582 c.3213C>G synonymous_variant 0.33 rifampicin
rpoC 766583 c.3214_3216delGGTinsAC frameshift_variant&missense_variant 0.32 rifampicin
rpoC 766591 c.3222A>G synonymous_variant 0.32 rifampicin
rpoC 766594 c.3225G>C synonymous_variant 0.31 rifampicin
rpoC 766597 c.3228C>G synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 766607 p.Ile1080Leu missense_variant 0.31 rifampicin
rpoC 766630 c.3261G>C synonymous_variant 0.37 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.33 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.3 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.32 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.41 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.42 rifampicin
rpoC 766801 c.3432C>G synonymous_variant 0.4 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.39 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.36 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.33 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.41 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.33 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.24 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.25 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.22 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.24 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.33 rifampicin
rpoC 767158 c.3789T>C synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.34 rifampicin
rpoC 767191 c.3822C>G synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoC 767206 c.3837C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767209 c.3840T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 767212 c.3843G>C synonymous_variant 0.25 rifampicin
rpoC 767221 c.3852C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 767230 c.3861G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 767233 c.3864T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 775981 p.Leu834Met missense_variant 0.18 clofazimine
bedaquiline
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 777133 p.Val450Ile missense_variant 0.16 clofazimine
bedaquiline
mmpL5 777158 c.1323C>G synonymous_variant 0.17 clofazimine
bedaquiline
mmpL5 777164 c.1317C>G synonymous_variant 0.19 clofazimine
bedaquiline
mmpL5 777170 c.1311T>C synonymous_variant 0.2 clofazimine
bedaquiline
mmpL5 777176 p.Glu435Asp missense_variant 0.19 clofazimine
bedaquiline
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781595 c.36T>C synonymous_variant 0.26 streptomycin
rpsL 781605 p.Ile16Val missense_variant 0.26 streptomycin Uncertain significance
rpsL 781608 p.Ser17Ala missense_variant 0.26 streptomycin
rpsL 781628 c.69T>C synonymous_variant 0.27 streptomycin Not assoc w R - Interim
rpsL 781631 c.72G>C synonymous_variant 0.26 streptomycin
rpsL 781649 c.90T>C synonymous_variant 0.25 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.22 streptomycin
rpsL 781682 c.123T>C synonymous_variant 0.2 streptomycin
rpsL 781700 c.141G>C synonymous_variant 0.2 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.2 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.2 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.23 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.26 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.28 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.29 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.3 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.3 streptomycin
rpsL 781772 c.213C>A synonymous_variant 0.3 streptomycin
rpsL 781808 c.249C>T synonymous_variant 0.29 streptomycin
rpsL 781811 c.252C>T synonymous_variant 0.31 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.25 streptomycin
rpsL 781838 c.279G>C synonymous_variant 0.23 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.26 streptomycin
rpsL 781865 c.306G>C synonymous_variant 0.25 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.26 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.27 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.27 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.28 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.27 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.28 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.32 streptomycin Uncertain significance
rplC 800546 c.-263T>G upstream_gene_variant 0.15 linezolid
rplC 800567 c.-242A>G upstream_gene_variant 0.17 linezolid
rplC 800582 c.-227C>G upstream_gene_variant 0.24 linezolid
rplC 800612 c.-197A>G upstream_gene_variant 0.28 linezolid
rplC 800618 c.-191T>C upstream_gene_variant 0.29 linezolid
rplC 800627 c.-182C>T upstream_gene_variant 0.32 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.35 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.33 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.34 linezolid
rplC 800703 c.-106T>C upstream_gene_variant 0.34 linezolid
rplC 800715 c.-94A>C upstream_gene_variant 0.27 linezolid
rplC 800720 c.-89T>C upstream_gene_variant 0.26 linezolid
rplC 800723 c.-86C>G upstream_gene_variant 0.27 linezolid
rplC 800747 c.-62C>G upstream_gene_variant 0.27 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.26 linezolid
rplC 800794 c.-15A>G upstream_gene_variant 0.23 linezolid
rplC 800796 c.-13A>G upstream_gene_variant 0.23 linezolid
rplC 800798 c.-10_-9delGG upstream_gene_variant 0.23 linezolid
rplC 800814 c.6A>G synonymous_variant 0.22 linezolid
rplC 800817 c.9A>T synonymous_variant 0.23 linezolid
rplC 800844 c.36T>C synonymous_variant 0.19 linezolid
rplC 800877 c.69A>T synonymous_variant 0.14 linezolid
rplC 800889 c.81C>G synonymous_variant 0.16 linezolid
rplC 800892 c.84G>C synonymous_variant 0.16 linezolid
rplC 800907 c.99C>G synonymous_variant 0.15 linezolid
rplC 801300 c.492C>G synonymous_variant 0.19 linezolid
rplC 801309 c.501C>G synonymous_variant 0.22 linezolid
rplC 801312 c.504G>C synonymous_variant 0.21 linezolid
rplC 801321 c.513C>T synonymous_variant 0.21 linezolid Not assoc w R - Interim
rplC 801324 c.516T>C synonymous_variant 0.18 linezolid
rplC 801339 c.531T>C synonymous_variant 0.21 linezolid
rplC 801341 p.Leu178Gln missense_variant 0.22 linezolid
rplC 801348 c.540T>G synonymous_variant 0.23 linezolid
rplC 801357 c.549T>C synonymous_variant 0.23 linezolid
rplC 801367 p.Ala187Thr missense_variant 0.27 linezolid
rplC 801402 c.594T>C synonymous_variant 0.17 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1303545 c.615A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303575 c.645G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303590 c.660A>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303752 c.822A>G synonymous_variant 0.15 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1303755 c.825T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303761 c.831T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303785 c.855G>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303797 c.867A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1303812 c.882C>T synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1303836 c.906G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1303845 c.915C>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303846 p.Phe306Val missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303854 c.924T>C synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303860 c.930A>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303884 c.954T>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303905 c.975G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>T synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303944 c.1014G>C synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303953 p.Asp341Glu missense_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303956 c.1026A>G synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1303971 c.1041T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304004 c.1074A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1304022 c.1092T>C synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1304031 c.1101C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304034 c.1104A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304040 c.1110C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304046 c.1116C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304049 c.1119T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304058 c.1128G>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304059 c.1129C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304064 c.1134G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304067 c.1137G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304097 c.1167G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304127 c.1197A>G synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304132 p.Ala401Gly missense_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304142 c.1212G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304161 p.Arg411Ser missense_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304169 c.1239T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304174 p.Val415Ala missense_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304184 c.1254G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304187 c.1257T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304535 c.1605G>A synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304553 c.1623C>T synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304559 p.Glu543Asp missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304565 c.1635C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304568 c.1638T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304580 c.1650T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304613 c.1683T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>C synonymous_variant 0.24 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304711 p.Ala594Asp missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304727 c.1797A>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304778 c.1848T>C synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.33 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.33 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.4 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304891 p.Ile654Thr missense_variant 0.35 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.39 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.38 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.43 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.37 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.32 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.28 clofazimine
pretomanid
delamanid
fbiC 1305012 c.2082G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305021 c.2091C>G synonymous_variant 0.29 clofazimine
pretomanid
delamanid
fbiC 1305030 c.2100G>C synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305033 c.2103T>G synonymous_variant 0.3 clofazimine
pretomanid
delamanid
fbiC 1305042 c.2112A>G synonymous_variant 0.31 clofazimine
pretomanid
delamanid
fbiC 1305063 c.2133G>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305066 c.2136T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305069 c.2139G>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305075 c.2145T>C synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305078 c.2148A>G synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305081 c.2151G>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305090 c.2160C>G synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305092 p.Ala721Gly missense_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305099 c.2169T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305114 c.2184T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1305117 c.2187T>C synonymous_variant 0.25 clofazimine
pretomanid
delamanid
fbiC 1305126 c.2196T>C synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1305135 c.2205C>T synonymous_variant 0.27 clofazimine
pretomanid
delamanid
fbiC 1305186 c.2256C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305318 c.2388C>G synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1305372 c.2442G>A synonymous_variant 0.2 clofazimine Not assoc w R - Interim
pretomanid
delamanid
fbiC 1305384 c.2454G>C synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305396 c.2466C>G synonymous_variant 0.23 clofazimine
pretomanid
delamanid
fbiC 1305405 c.2475A>G synonymous_variant 0.22 clofazimine Not assoc w R - Interim
pretomanid
delamanid
Rv1258c 1406165 c.1176G>T synonymous_variant 1.0 streptomycin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
pyrazinamide Not assoc w R - Interim
Rv1258c 1406760 c.580_581insC frameshift_variant 0.97 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.2 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.26 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.26 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.29 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.23 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1476690 n.3033C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid
rrl 1476693 n.3036G>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1476716 n.3059A>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
inhA 1673523 c.-679G>T upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1673535 c.-667A>G upstream_gene_variant 0.22 ethionamide
isoniazid
inhA 1673547 c.-655T>C upstream_gene_variant 0.25 ethionamide
isoniazid
inhA 1673568 c.-634C>G upstream_gene_variant 0.25 ethionamide
isoniazid
inhA 1673574 c.-628C>G upstream_gene_variant 0.26 ethionamide
isoniazid
inhA 1673580 c.-622T>G upstream_gene_variant 0.24 ethionamide
isoniazid Uncertain significance
fabG1 1673710 p.Leu91Ile missense_variant 0.16 ethionamide
isoniazid
fabG1 1673890 p.Ala151Ser missense_variant 0.15 ethionamide
isoniazid
inhA 1673901 c.-301A>G upstream_gene_variant 0.19 ethionamide
isoniazid
fabG1 1673905 p.Ser156Ala missense_variant 0.18 ethionamide
isoniazid
inhA 1673916 c.-286A>C upstream_gene_variant 0.19 ethionamide
isoniazid
fabG1 1673917 p.Val160Leu missense_variant 0.19 ethionamide
isoniazid
inhA 1673922 c.-280T>C upstream_gene_variant 0.21 ethionamide
isoniazid
fabG1 1673941 p.Ala168Ser missense_variant 0.21 ethionamide
isoniazid
inhA 1673955 c.-247G>C upstream_gene_variant 0.21 ethionamide
isoniazid
inhA 1673961 c.-241A>C upstream_gene_variant 0.2 ethionamide
isoniazid
inhA 1673985 c.-217C>G upstream_gene_variant 0.16 ethionamide
isoniazid
fabG1 1674006 p.Asp189Glu missense_variant 0.17 ethionamide
isoniazid
inhA 1674060 c.-142A>G upstream_gene_variant 0.17 ethionamide
isoniazid
inhA 1674063 c.-139G>C upstream_gene_variant 0.19 ethionamide
isoniazid
fabG1 1674079 p.Pro214Ala missense_variant 0.22 ethionamide
isoniazid
inhA 1674114 c.-88T>A upstream_gene_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674123 c.-79T>C upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1674126 c.-76G>C upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1674132 c.-70T>C upstream_gene_variant 0.19 ethionamide
isoniazid
fabG1 1674136 p.Ser233Ala missense_variant 0.19 ethionamide
isoniazid
inhA 1674141 c.-61T>C upstream_gene_variant 0.19 ethionamide
isoniazid
inhA 1674156 c.-46C>G upstream_gene_variant 0.18 ethionamide
isoniazid
inhA 1674537 c.336C>G synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674542 p.Ala114Glu missense_variant 0.2 ethionamide
isoniazid
inhA 1674546 c.345T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674549 c.348G>C synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674552 c.351C>G synonymous_variant 0.18 ethionamide
isoniazid
inhA 1674555 c.354G>A synonymous_variant 0.18 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674561 c.360C>T synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674582 c.381T>C synonymous_variant 0.19 ethionamide
isoniazid
inhA 1674585 c.384T>C synonymous_variant 0.2 ethionamide
isoniazid
inhA 1674589 p.Met130Leu missense_variant 0.2 ethionamide
isoniazid
inhA 1674601 p.Leu134Thr missense_variant 0.18 ethionamide
isoniazid
inhA 1674624 c.423A>C synonymous_variant 0.21 ethionamide
isoniazid
inhA 1674630 c.429C>G synonymous_variant 0.22 ethionamide
isoniazid
inhA 1674660 c.459G>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674672 c.471C>G synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674703 c.502T>C synonymous_variant 0.17 ethionamide
isoniazid
inhA 1674708 c.507G>A synonymous_variant 0.15 ethionamide
isoniazid
inhA 1674828 c.627G>A synonymous_variant 0.16 ethionamide
isoniazid
inhA 1674846 p.Ile215Met missense_variant 0.23 ethionamide
isoniazid
inhA 1674855 c.654C>G synonymous_variant 0.28 ethionamide
isoniazid Not assoc w R - Interim
inhA 1674864 c.663C>T synonymous_variant 0.27 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674870 c.669T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674879 c.678T>C synonymous_variant 0.24 ethionamide
isoniazid
inhA 1674903 c.702T>C synonymous_variant 0.26 ethionamide
isoniazid
inhA 1674904 p.Ala235Pro missense_variant 0.26 ethionamide
isoniazid
inhA 1674909 c.708G>A synonymous_variant 0.24 ethionamide
isoniazid
rpsA 1833554 p.Thr5Ala missense_variant 0.15 pyrazinamide Uncertain significance
rpsA 1833568 c.27G>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
rpsA 1833589 c.48A>T synonymous_variant 0.17 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.17 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.18 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.22 pyrazinamide
rpsA 1833721 c.180A>G synonymous_variant 0.3 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.3 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.3 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.31 pyrazinamide
rpsA 1833745 c.204G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833748 c.207C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.3 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.29 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.31 pyrazinamide
rpsA 1833838 c.297G>C synonymous_variant 0.31 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.32 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.31 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.28 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.22 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.22 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.27 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.26 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.26 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.2 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.18 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834195 c.654G>C synonymous_variant 0.15 pyrazinamide
rpsA 1834210 c.669C>T synonymous_variant 0.15 pyrazinamide
rpsA 1834333 c.792C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.18 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.22 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.25 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834510 c.969C>T synonymous_variant 0.29 pyrazinamide Not assoc w R - Interim
rpsA 1834513 c.972C>G synonymous_variant 0.3 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834540 c.999G>C synonymous_variant 0.28 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.28 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834654 p.Glu371Asp missense_variant 0.23 pyrazinamide
rpsA 1834684 c.1143C>T synonymous_variant 0.17 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834733 p.Ala398Ser missense_variant 0.25 pyrazinamide
rpsA 1834738 c.1197A>G synonymous_variant 0.26 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.27 pyrazinamide
rpsA 1834765 p.Glu408Asp missense_variant 0.23 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.2 pyrazinamide
rpsA 1834780 c.1239A>G synonymous_variant 0.21 pyrazinamide
rpsA 1834786 c.1245A>G synonymous_variant 0.2 pyrazinamide
rpsA 1834789 c.1248T>C synonymous_variant 0.2 pyrazinamide
rpsA 1834792 c.1251G>C synonymous_variant 0.2 pyrazinamide
tsnR 1853361 c.-245T>C upstream_gene_variant 0.26 linezolid
tsnR 1853370 c.-236_-234delGCAinsTG upstream_gene_variant 0.24 linezolid
tsnR 1853387 c.-219T>G upstream_gene_variant 0.31 linezolid
tsnR 1853394 c.-212_-211delCTinsGC upstream_gene_variant 0.27 linezolid
tsnR 1853420 c.-186T>G upstream_gene_variant 0.24 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.19 linezolid
tsnR 1853432 c.-174G>C upstream_gene_variant 0.19 linezolid
tsnR 1853447 c.-159C>G upstream_gene_variant 0.23 linezolid
tsnR 1853459 c.-147G>C upstream_gene_variant 0.19 linezolid
tsnR 1853462 c.-144A>G upstream_gene_variant 0.18 linezolid
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
tlyA 1918221 c.282T>C synonymous_variant 0.17 capreomycin
tlyA 1918224 c.285G>C synonymous_variant 0.19 capreomycin
tlyA 1918236 c.297A>C synonymous_variant 0.22 capreomycin
tlyA 1918248 c.309T>C synonymous_variant 0.23 capreomycin
tlyA 1918251 c.312T>G synonymous_variant 0.22 capreomycin
tlyA 1918271 p.Ala111Val missense_variant 0.2 capreomycin
tlyA 1918275 c.336T>C synonymous_variant 0.19 capreomycin
tlyA 1918278 c.339C>G synonymous_variant 0.19 capreomycin
tlyA 1918425 c.486C>A synonymous_variant 0.15 capreomycin
bacA 2063271 c.1458G>T synonymous_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063276 p.His485Tyr missense_variant 0.16 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063280 c.1449C>G synonymous_variant 0.17 streptomycin
kanamycin
capreomycin
amikacin
bacA 2063283 c.1446G>A synonymous_variant 0.17 streptomycin Not assoc w R - Interim
kanamycin
capreomycin
amikacin
bacA 2063303 c.1426C>T synonymous_variant 0.2 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin
amikacin Not assoc w R - Interim
bacA 2064972 c.-244T>C upstream_gene_variant 0.25 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064978 c.-250G>C upstream_gene_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064979 c.-251C>T upstream_gene_variant 0.24 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064984 c.-256A>G upstream_gene_variant 0.26 streptomycin
kanamycin
capreomycin
amikacin
bacA 2064993 c.-265T>C upstream_gene_variant 0.3 streptomycin
kanamycin
capreomycin
amikacin
ndh 2101756 c.1287G>C synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2101765 c.1278C>G synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101768 c.1275C>A synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2101771 c.1272T>G synonymous_variant 0.21 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2101774 c.1269T>C synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101777 c.1266C>G synonymous_variant 0.21 ethionamide Not assoc w R - Interim
delamanid
isoniazid Not assoc w R - Interim
ndh 2101783 c.1260T>A synonymous_variant 0.21 ethionamide
delamanid
isoniazid
ndh 2101804 c.1239T>G synonymous_variant 0.19 ethionamide
delamanid
isoniazid
ndh 2101808 p.Thr412Ser missense_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2101830 p.Ile405Val missense_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2101939 c.1104A>G synonymous_variant 0.16 ethionamide
delamanid
isoniazid
ndh 2101960 c.1083A>G synonymous_variant 0.22 ethionamide
delamanid
isoniazid
ndh 2101963 c.1080G>A synonymous_variant 0.23 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2101966 c.1077T>G synonymous_variant 0.25 ethionamide
delamanid
isoniazid
ndh 2101972 c.1071G>C synonymous_variant 0.26 ethionamide
delamanid
isoniazid
ndh 2101988 p.Ala352Asp missense_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2101990 c.1053G>C synonymous_variant 0.23 ethionamide
delamanid
isoniazid
ndh 2101993 c.1050A>G synonymous_variant 0.24 ethionamide
delamanid
isoniazid
ndh 2102011 c.1032C>G synonymous_variant 0.19 ethionamide Not assoc w R - Interim
delamanid Not assoc w R - Interim
isoniazid Not assoc w R - Interim
ndh 2102014 c.1029C>G synonymous_variant 0.17 ethionamide
delamanid
isoniazid
ndh 2102020 c.1023A>G synonymous_variant 0.18 ethionamide
delamanid
isoniazid
ndh 2102023 c.1020G>C synonymous_variant 0.18 ethionamide
delamanid
isoniazid Not assoc w R - Interim
ndh 2102026 c.1017G>C synonymous_variant 0.18 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 0.99 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289925 c.-684T>C upstream_gene_variant 0.16 pyrazinamide
pncA 2289930 c.-689A>G upstream_gene_variant 0.16 pyrazinamide
kasA 2517950 c.-165C>G upstream_gene_variant 0.28 isoniazid
kasA 2517989 c.-126T>C upstream_gene_variant 0.19 isoniazid
kasA 2517993 c.-122G>T upstream_gene_variant 0.17 isoniazid
kasA 2518162 c.48G>A synonymous_variant 0.19 isoniazid
kasA 2518174 c.60A>G synonymous_variant 0.2 isoniazid
kasA 2518190 p.Ser26Ala missense_variant 0.2 isoniazid
kasA 2518199 p.Ile29Val missense_variant 0.18 isoniazid
kasA 2518220 c.106C>T synonymous_variant 0.2 isoniazid
kasA 2518234 c.120G>A synonymous_variant 0.16 isoniazid
kasA 2518459 c.345T>C synonymous_variant 0.17 isoniazid
kasA 2518462 c.348A>C synonymous_variant 0.17 isoniazid
kasA 2518468 c.354A>C synonymous_variant 0.18 isoniazid
kasA 2518474 c.360G>A synonymous_variant 0.21 isoniazid
kasA 2518480 c.366T>C synonymous_variant 0.21 isoniazid
kasA 2518483 c.369C>G synonymous_variant 0.21 isoniazid
kasA 2518504 c.390T>C synonymous_variant 0.22 isoniazid
kasA 2518506 p.Ala131Glu missense_variant 0.23 isoniazid
kasA 2518519 c.405G>C synonymous_variant 0.2 isoniazid
kasA 2518528 c.414C>G synonymous_variant 0.19 isoniazid
kasA 2518540 c.426T>C synonymous_variant 0.22 isoniazid
kasA 2518624 c.510C>G synonymous_variant 0.15 isoniazid
kasA 2518672 c.558G>C synonymous_variant 0.27 isoniazid
kasA 2518678 c.564C>T synonymous_variant 0.26 isoniazid
kasA 2518684 c.570C>G synonymous_variant 0.29 isoniazid
kasA 2518696 c.582C>G synonymous_variant 0.28 isoniazid
kasA 2518702 c.588C>T synonymous_variant 0.26 isoniazid
kasA 2518705 c.591T>C synonymous_variant 0.32 isoniazid
kasA 2518711 c.597A>G synonymous_variant 0.33 isoniazid
kasA 2518714 c.600A>C synonymous_variant 0.35 isoniazid
kasA 2518732 c.618C>G synonymous_variant 0.38 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.41 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.41 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.41 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.36 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.35 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.33 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.36 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.36 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.38 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.34 isoniazid
kasA 2518879 c.765A>G synonymous_variant 0.4 isoniazid
kasA 2518885 c.771T>C synonymous_variant 0.38 isoniazid
kasA 2518898 c.784T>C synonymous_variant 0.35 isoniazid
kasA 2518906 c.792A>G synonymous_variant 0.33 isoniazid
kasA 2518910 p.Leu266Met missense_variant 0.3 isoniazid
kasA 2518921 c.807T>C synonymous_variant 0.33 isoniazid
kasA 2518936 c.822C>G synonymous_variant 0.26 isoniazid
kasA 2518939 c.825T>C synonymous_variant 0.27 isoniazid
kasA 2518942 c.828T>C synonymous_variant 0.25 isoniazid
kasA 2518951 c.837G>C synonymous_variant 0.27 isoniazid
kasA 2518954 c.840C>G synonymous_variant 0.27 isoniazid
kasA 2518963 c.849T>C synonymous_variant 0.3 isoniazid
kasA 2518969 c.855T>G synonymous_variant 0.28 isoniazid
kasA 2518975 c.861C>G synonymous_variant 0.3 isoniazid
kasA 2518979 c.865A>C synonymous_variant 0.33 isoniazid
kasA 2518990 c.876T>G synonymous_variant 0.31 isoniazid
kasA 2518993 c.879C>G synonymous_variant 0.3 isoniazid
kasA 2518999 c.885G>C synonymous_variant 0.33 isoniazid
kasA 2519008 c.894C>G synonymous_variant 0.34 isoniazid
kasA 2519017 c.903G>C synonymous_variant 0.27 isoniazid
kasA 2519020 c.906G>C synonymous_variant 0.26 isoniazid
kasA 2519021 p.Ala303Lys missense_variant 0.25 isoniazid
kasA 2519027 c.913_915delATCinsGT frameshift_variant&missense_variant 0.24 isoniazid
kasA 2519050 c.936C>G synonymous_variant 0.25 isoniazid
kasA 2519053 c.939G>C synonymous_variant 0.25 isoniazid
kasA 2519056 c.942G>C synonymous_variant 0.28 isoniazid
kasA 2519062 c.948T>G synonymous_variant 0.28 isoniazid
kasA 2519068 c.954C>T synonymous_variant 0.27 isoniazid
kasA 2519072 p.Ala320Thr missense_variant 0.26 isoniazid
kasA 2519107 c.993T>C synonymous_variant 0.32 isoniazid
kasA 2519108 c.994_996delGATinsCG frameshift_variant&missense_variant 0.29 isoniazid
kasA 2519116 c.1002C>G synonymous_variant 0.3 isoniazid
kasA 2519122 c.1008G>C synonymous_variant 0.3 isoniazid
kasA 2519137 c.1023T>G synonymous_variant 0.29 isoniazid
kasA 2519158 c.1044C>T synonymous_variant 0.23 isoniazid
kasA 2519167 c.1053T>G synonymous_variant 0.24 isoniazid
kasA 2519173 c.1059C>G synonymous_variant 0.21 isoniazid
ahpC 2726636 c.444G>A synonymous_variant 0.98 isoniazid Not assoc w R - Interim
folC 2747032 c.567A>C synonymous_variant 0.2 para-aminosalicylic_acid
folC 2747059 c.540T>C synonymous_variant 0.26 para-aminosalicylic_acid
folC 2747062 c.537A>G synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747065 c.534C>T synonymous_variant 0.27 para-aminosalicylic_acid
folC 2747071 c.528C>G synonymous_variant 0.27 para-aminosalicylic_acid
folC 2747086 c.513A>C synonymous_variant 0.27 para-aminosalicylic_acid
folC 2747089 c.510G>C synonymous_variant 0.26 para-aminosalicylic_acid
folC 2747101 c.498G>C synonymous_variant 0.28 para-aminosalicylic_acid
folC 2747107 c.492G>C synonymous_variant 0.26 para-aminosalicylic_acid
folC 2747110 c.489T>C synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747113 c.486C>G synonymous_variant 0.23 para-aminosalicylic_acid
folC 2747116 c.483G>C synonymous_variant 0.24 para-aminosalicylic_acid
folC 2747264 p.Gly112Ala missense_variant 0.24 para-aminosalicylic_acid
folC 2747266 c.333C>T synonymous_variant 0.25 para-aminosalicylic_acid
folC 2747275 c.324T>C synonymous_variant 0.29 para-aminosalicylic_acid
folC 2747289 p.Pro104Ala missense_variant 0.33 para-aminosalicylic_acid
folC 2747290 c.309A>G synonymous_variant 0.33 para-aminosalicylic_acid
folC 2747293 c.306G>A synonymous_variant 0.34 para-aminosalicylic_acid
folC 2747302 c.297A>G synonymous_variant 0.36 para-aminosalicylic_acid
folC 2747314 c.285A>C synonymous_variant 0.37 para-aminosalicylic_acid
folC 2747317 c.282C>G synonymous_variant 0.37 para-aminosalicylic_acid
folC 2747343 p.Val86Ile missense_variant 0.29 para-aminosalicylic_acid
folC 2747355 p.Val82Ile missense_variant 0.25 para-aminosalicylic_acid
folC 2747359 c.240C>G synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747362 c.237G>C synonymous_variant 0.21 para-aminosalicylic_acid
folC 2747395 c.204T>C synonymous_variant 0.15 para-aminosalicylic_acid
folC 2747442 c.157T>C synonymous_variant 0.16 para-aminosalicylic_acid
folC 2747790 c.-192G>C upstream_gene_variant 0.17 para-aminosalicylic_acid
Rv2477c 2782483 c.1560G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782522 c.1521G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782894 c.1149C>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782912 p.Ser377Thr missense_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782927 p.Thr372Glu missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782936 c.1107G>T synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782957 c.1086A>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2782969 c.1074A>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782972 c.1071G>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782981 c.1062G>C synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782984 c.1059T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2782990 c.1053C>G synonymous_variant 0.27 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783002 c.1041T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783008 c.1035C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783059 c.984T>C synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783068 p.Asp325Glu missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.32 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.32 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783107 c.936G>A synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783149 c.894G>C synonymous_variant 0.27 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783182 c.861C>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783185 c.858G>A synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.3 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783221 c.822G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783230 c.813T>G synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783332 c.711T>C synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783335 c.708C>G synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783350 c.693T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783353 c.690T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783359 c.684G>A synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783374 c.669G>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783395 c.648T>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.16 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783563 c.480A>G synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.31 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>A synonymous_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.52 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783776 c.267G>C synonymous_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783779 c.264T>C synonymous_variant 0.51 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783821 p.Gln74Leu missense_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783833 c.210G>C synonymous_variant 0.49 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783839 c.204C>G synonymous_variant 0.46 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783843 p.Gly67Asp missense_variant 0.44 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783846 p.Thr66Asn missense_variant 0.42 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783860 c.183T>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783863 c.180C>T synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783883 c.160T>C synonymous_variant 0.37 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783884 c.159T>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783887 c.156C>G synonymous_variant 0.37 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.36 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783929 c.114C>G synonymous_variant 0.33 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783932 c.111C>T synonymous_variant 0.29 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783938 c.105T>C synonymous_variant 0.28 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783953 c.90G>A synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783962 c.81T>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2784375 c.-333T>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784378 c.-336A>G upstream_gene_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784381 c.-339T>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784390 c.-348G>C upstream_gene_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784396 c.-354A>C upstream_gene_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784428 c.-386T>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784429 c.-387A>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784432 c.-390A>C upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784435 c.-393C>G upstream_gene_variant 0.21 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784452 c.-410C>T upstream_gene_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784456 c.-414A>C upstream_gene_variant 0.22 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784472 c.-430C>A upstream_gene_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784477 c.-435T>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ribD 2987026 p.Ala63Gly missense_variant 0.14 para-aminosalicylic_acid
Rv2681 2996940 p.Gly68Asn missense_variant 0.22 capreomycin
Rv2681 2996945 c.207C>G synonymous_variant 0.22 capreomycin
Rv2681 2996957 c.219T>C synonymous_variant 0.21 capreomycin
Rv2681 2996966 c.228G>C synonymous_variant 0.22 capreomycin
Rv2681 2996972 c.234C>G synonymous_variant 0.23 capreomycin
Rv2681 2996974 p.Glu79Gly missense_variant 0.21 capreomycin
Rv2681 2996976 p.Ala80Ser missense_variant 0.21 capreomycin
Rv2681 2996987 c.249A>G synonymous_variant 0.2 capreomycin
Rv2752c 3066330 c.-139G>C upstream_gene_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066335 c.-144T>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066522 c.-331C>G upstream_gene_variant 0.16 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066531 c.-340C>G upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066549 c.-358T>C upstream_gene_variant 0.2 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.18 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066567 c.-376C>G upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066572 c.-381G>A upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066573 c.-382G>C upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066579 c.-388A>G upstream_gene_variant 0.17 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3066810 c.-619G>A upstream_gene_variant 0.15 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067316 c.630A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067325 c.621A>G synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067349 c.597G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067355 c.591A>C synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067367 c.579G>C synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067373 c.573C>G synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067379 c.567C>T synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.27 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.21 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067462 c.484C>T synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.18 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067490 p.Ala152Glu missense_variant 0.21 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.27 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.26 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.33 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.31 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.33 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.33 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.33 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067601 p.Arg115His missense_variant 0.38 para-aminosalicylic_acid
thyX 3067611 p.Lys112Thr missense_variant 0.36 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067631 c.315C>G synonymous_variant 0.36 para-aminosalicylic_acid
thyX 3067634 c.312C>G synonymous_variant 0.37 para-aminosalicylic_acid
thyX 3067652 c.294T>C synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067661 c.285C>G synonymous_variant 0.33 para-aminosalicylic_acid
thyX 3067685 c.261A>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067691 c.253_255delATCinsCG frameshift_variant&missense_variant 0.23 para-aminosalicylic_acid
thyX 3067694 c.252G>C synonymous_variant 0.23 para-aminosalicylic_acid
thyX 3067702 p.Ile82Val missense_variant 0.22 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067736 c.210C>T synonymous_variant 0.3 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.27 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.29 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.34 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.35 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.31 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067850 c.96A>C synonymous_variant 0.32 para-aminosalicylic_acid
thyX 3067869 p.Thr26Ser missense_variant 0.29 para-aminosalicylic_acid
thyX 3067874 c.72C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067877 c.69G>C synonymous_variant 0.24 para-aminosalicylic_acid
thyX 3067883 c.63C>G synonymous_variant 0.25 para-aminosalicylic_acid
thyX 3067886 c.60A>C synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067889 c.57C>G synonymous_variant 0.26 para-aminosalicylic_acid
thyX 3067898 p.Asp16Glu missense_variant 0.25 para-aminosalicylic_acid
thyX 3068136 c.-191A>G upstream_gene_variant 1.0 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087704 c.885T>C synonymous_variant 0.16 cycloserine
ald 3087716 c.897G>C synonymous_variant 0.17 cycloserine
whiB7 3569166 c.-487C>G upstream_gene_variant 0.15 streptomycin
amikacin
kanamycin
whiB7 3569169 c.-490T>C upstream_gene_variant 0.15 streptomycin
amikacin
kanamycin
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
lpqB 3624050 c.861C>G synonymous_variant 0.17 bedaquiline
rifampicin
lpqB 3624077 c.834G>A synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624082 c.829A>C synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624092 c.817_819delAGGinsCC frameshift_variant&missense_variant 0.18 bedaquiline
rifampicin Uncertain significance
lpqB 3624100 c.811T>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624101 c.810C>G synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624116 c.795A>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624119 c.792C>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624124 p.Leu263Val missense_variant 0.2 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624143 c.768T>C synonymous_variant 0.21 bedaquiline
rifampicin
lpqB 3624722 c.189C>G synonymous_variant 0.21 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624728 c.183C>T synonymous_variant 0.23 bedaquiline
rifampicin
lpqB 3624749 c.162G>A synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624755 c.154_156delTTAinsCG frameshift_variant&missense_variant 0.17 bedaquiline
rifampicin Uncertain significance
lpqB 3624783 p.Ser43Thr missense_variant 0.16 bedaquiline
rifampicin
lpqB 3625045 c.-135C>T upstream_gene_variant 0.95 bedaquiline
rifampicin
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
lpqB 3625510 c.-600T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
lpqB 3625513 c.-603G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
lpqB 3625518 c.-608T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625525 c.-615G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
lpqB 3625528 c.-618G>T upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625537 c.-627T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625543 c.-633G>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3625569 c.1045T>C synonymous_variant 0.31 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625572 p.Thr348Ser missense_variant 0.31 bedaquiline
rifampicin
lpqB 3625579 c.-669A>G upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625594 c.-684T>C upstream_gene_variant 0.32 bedaquiline
rifampicin
lpqB 3625602 c.-692T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
lpqB 3625612 c.-702G>C upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrB 3625616 p.Arg333Ala missense_variant 0.27 bedaquiline
rifampicin
lpqB 3625624 c.-714C>G upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrB 3625636 c.978C>G synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625656 c.958T>C synonymous_variant 0.32 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3625663 c.-753G>C upstream_gene_variant 0.29 bedaquiline
rifampicin
lpqB 3625669 c.-759G>C upstream_gene_variant 0.27 bedaquiline
rifampicin
lpqB 3625687 c.-777G>C upstream_gene_variant 0.25 bedaquiline
rifampicin
lpqB 3625690 c.-780T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
lpqB 3625696 c.-786A>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3625705 c.909C>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625711 c.903C>T synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625714 c.-804C>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3625720 c.894G>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625729 c.885A>G synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625735 c.-825C>T upstream_gene_variant 0.19 bedaquiline
rifampicin
lpqB 3625749 c.-839C>T upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3625750 c.864G>A synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.23 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625792 c.-882G>A upstream_gene_variant 0.32 bedaquiline
rifampicin
mtrB 3625797 p.Val273Met missense_variant 0.32 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.33 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625843 c.-933C>G upstream_gene_variant 0.35 bedaquiline
rifampicin
lpqB 3625849 c.-939T>C upstream_gene_variant 0.37 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.37 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625864 c.-954T>G upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrB 3625876 c.738G>C synonymous_variant 0.29 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626154 c.460C>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626155 c.457_459delGCGinsTC frameshift_variant&missense_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626158 c.456C>T synonymous_variant 0.17 bedaquiline
rifampicin
mtrB 3626562 p.Pro18Ser missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626687 c.-74G>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626704 c.-91C>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626711 c.-98T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3626723 c.627C>T synonymous_variant 0.26 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626726 c.-113T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626729 c.-116G>A upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrB 3626732 c.-119A>G upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrA 3626759 c.591T>C synonymous_variant 0.36 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626774 c.574_576delAGGinsCC frameshift_variant&missense_variant 0.3 bedaquiline
rifampicin
mtrB 3626783 c.-170C>G upstream_gene_variant 0.27 bedaquiline
rifampicin
mtrA 3626786 c.564A>G synonymous_variant 0.27 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3626792 c.558G>T synonymous_variant 0.3 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.3 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.31 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.35 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.26 bedaquiline
rifampicin
mtrA 3626846 c.504G>A synonymous_variant 0.22 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626858 c.-245A>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626861 c.-248C>G upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626866 c.-253T>C upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3626869 c.481C>T synonymous_variant 0.19 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626876 c.-263A>G upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626885 c.-272A>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626890 c.-277T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3626903 c.-290T>C upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3626912 c.-299T>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3626927 c.-314G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3626930 c.-317A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3626939 c.411A>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626942 c.-329A>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627071 c.279G>T synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627098 c.252A>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627146 c.204C>T synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627167 c.-554T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3627181 c.-568T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627182 c.-569T>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627188 c.162A>G synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627209 c.-596G>A upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrA 3627221 c.129C>T synonymous_variant 0.25 bedaquiline
rifampicin Not assoc w R - Interim
mtrA 3627227 c.123T>C synonymous_variant 0.24 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627233 c.-620T>C upstream_gene_variant 0.25 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3627242 c.108C>T synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627254 c.-641C>T upstream_gene_variant 0.23 bedaquiline
rifampicin
mtrB 3627263 c.-650C>T upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627272 c.-659G>T upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrB 3627275 c.-662G>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3627296 c.-683T>C upstream_gene_variant 0.29 bedaquiline
rifampicin
mtrA 3627299 c.49_51delTTGinsCA frameshift_variant&missense_variant 0.28 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.28 bedaquiline
rifampicin
mtrA 3627343 p.Thr3Ser missense_variant 0.27 bedaquiline
rifampicin
mtrB 3627360 c.-747G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627893 c.-544T>G upstream_gene_variant 0.19 bedaquiline
rifampicin
mtrA 3627917 c.-568G>C upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrA 3627920 c.-571A>G upstream_gene_variant 0.21 bedaquiline
rifampicin
fbiB 3640866 c.-669T>C upstream_gene_variant 0.18 clofazimine
pretomanid
delamanid
fbiA 3640871 p.Ala110Gly missense_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3640878 c.-657T>C upstream_gene_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3640899 c.-636G>C upstream_gene_variant 0.19 clofazimine
pretomanid
delamanid
fbiB 3640914 c.-621C>G upstream_gene_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3640920 c.-615A>G upstream_gene_variant 0.2 clofazimine
pretomanid
delamanid
fbiB 3642743 c.1209T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiB 3642763 p.Asp410Ala missense_variant 0.26 clofazimine
pretomanid
delamanid
rpoA 3877553 p.Glu319Gln missense_variant 0.33 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.28 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.25 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.3 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.32 rifampicin
rpoA 3877679 p.Ala277Ser missense_variant 0.3 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.33 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.24 rifampicin
rpoA 3877818 c.690A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877848 c.660C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.24 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.22 rifampicin
rpoA 3877875 c.633T>G synonymous_variant 0.21 rifampicin
rpoA 3877878 c.630G>C synonymous_variant 0.2 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.19 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.2 rifampicin
rpoA 3877900 p.Ser203Asn missense_variant 0.19 rifampicin
rpoA 3877923 c.585C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.2 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.16 rifampicin
rpoA 3878247 c.261G>C synonymous_variant 0.17 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.19 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.24 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.25 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.27 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.32 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.29 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.31 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.24 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.25 rifampicin
rpoA 3878713 c.-206G>A upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878716 c.-209C>G upstream_gene_variant 0.19 rifampicin
rpoA 3878725 c.-218A>G upstream_gene_variant 0.19 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.2 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.19 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.22 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.22 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.23 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.22 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.2 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.23 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.23 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.26 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.23 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.22 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.27 rifampicin
rpoA 3878860 c.-353C>T upstream_gene_variant 0.29 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878909 c.-402A>G upstream_gene_variant 0.38 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.38 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.35 rifampicin Uncertain significance
rpoA 3878938 c.-431T>A upstream_gene_variant 0.37 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.4 rifampicin Uncertain significance
rpoA 3878962 c.-455G>A upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.3 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.31 rifampicin Uncertain significance
rpoA 3878986 c.-479G>C upstream_gene_variant 0.29 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.28 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.25 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.28 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.23 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.24 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.25 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.31 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.33 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.38 rifampicin
rpoA 3879178 c.-671T>C upstream_gene_variant 0.38 rifampicin
rpoA 3879190 c.-683C>G upstream_gene_variant 0.39 rifampicin
rpoA 3879222 c.-715T>C upstream_gene_variant 0.23 rifampicin
rpoA 3879226 c.-719G>C upstream_gene_variant 0.21 rifampicin
rpoA 3879229 c.-722A>G upstream_gene_variant 0.21 rifampicin
rpoA 3879232 c.-725A>G upstream_gene_variant 0.2 rifampicin
clpC1 4038255 p.Val817Lys missense_variant 0.32 pyrazinamide
clpC1 4038271 p.Pro812Ala missense_variant 0.29 pyrazinamide
clpC1 4038272 c.2431_2433delGGTinsAC frameshift_variant&missense_variant 0.28 pyrazinamide
clpC1 4038275 c.2430A>G synonymous_variant 0.27 pyrazinamide
clpC1 4038278 c.2427T>C synonymous_variant 0.28 pyrazinamide
clpC1 4038293 c.2412G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038302 c.2403C>G synonymous_variant 0.31 pyrazinamide
clpC1 4038308 c.2397G>T synonymous_variant 0.3 pyrazinamide
clpC1 4038314 c.2391T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038317 c.2388G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038320 c.2385G>T synonymous_variant 0.31 pyrazinamide
clpC1 4038356 c.2349T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038359 c.2346A>G synonymous_variant 0.36 pyrazinamide
clpC1 4038368 c.2337T>C synonymous_variant 0.38 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.41 pyrazinamide
clpC1 4038392 c.2313C>T synonymous_variant 0.42 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.41 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.41 pyrazinamide Not assoc w R - Interim
clpC1 4038407 c.2298G>C synonymous_variant 0.4 pyrazinamide
clpC1 4038419 c.2286T>C synonymous_variant 0.36 pyrazinamide
clpC1 4038433 c.2272C>T synonymous_variant 0.28 pyrazinamide
clpC1 4038434 c.2271G>A synonymous_variant 0.27 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.25 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038456 p.Val750Glu missense_variant 0.33 pyrazinamide
clpC1 4038460 p.Leu749Met missense_variant 0.32 pyrazinamide
clpC1 4038509 c.2196C>T synonymous_variant 0.23 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.25 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.14 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.25 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.23 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.22 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.22 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.25 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038749 c.1956C>A synonymous_variant 0.22 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.22 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.22 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.39 pyrazinamide Not assoc w R - Interim
clpC1 4038893 c.1812C>T synonymous_variant 0.38 pyrazinamide
clpC1 4038908 c.1797C>G synonymous_variant 0.33 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.3 pyrazinamide
clpC1 4038923 c.1780_1782delCTAinsTG frameshift_variant&synonymous_variant 0.31 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.25 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.24 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.21 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.26 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.36 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.37 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.38 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.4 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.37 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.37 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.35 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.34 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.31 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.29 pyrazinamide
clpC1 4039186 c.1519C>T synonymous_variant 0.3 pyrazinamide
clpC1 4039190 c.1515C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.24 pyrazinamide Not assoc w R - Interim
clpC1 4039229 c.1476C>G synonymous_variant 0.23 pyrazinamide
clpC1 4039286 c.1419T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.22 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.2 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.2 pyrazinamide
clpC1 4039331 c.1374C>G synonymous_variant 0.21 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.2 pyrazinamide
clpC1 4039349 c.1356C>T synonymous_variant 0.22 pyrazinamide
clpC1 4039352 c.1353C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039430 c.1275T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.2 pyrazinamide
clpC1 4039454 c.1251A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.21 pyrazinamide
clpC1 4039481 c.1224T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.22 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.2 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039751 c.954A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039757 c.948A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039790 c.915C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039817 c.888A>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039820 c.885T>G synonymous_variant 0.26 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.32 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.35 pyrazinamide
clpC1 4039850 c.855T>C synonymous_variant 0.28 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.27 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.27 pyrazinamide
clpC1 4039937 c.768G>C synonymous_variant 0.35 pyrazinamide
clpC1 4039946 c.759A>C synonymous_variant 0.34 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.34 pyrazinamide
clpC1 4039982 c.723G>A synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4039988 c.717C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039991 c.714G>C synonymous_variant 0.3 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.3 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.32 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.31 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.28 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.3 pyrazinamide
clpC1 4040147 c.558A>G synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040162 c.543G>C synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4040165 c.540G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040171 c.534C>G synonymous_variant 0.24 pyrazinamide
clpC1 4040201 c.504C>G synonymous_variant 0.21 pyrazinamide
clpC1 4040237 c.468C>T synonymous_variant 0.25 pyrazinamide
clpC1 4040246 c.459C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040249 c.456A>G synonymous_variant 0.23 pyrazinamide
clpC1 4040267 c.438A>G synonymous_variant 0.22 pyrazinamide Not assoc w R - Interim
clpC1 4040273 c.432T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4040276 c.427_429delTCCinsAGT synonymous_variant 0.2 pyrazinamide
clpC1 4040279 c.426C>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4040291 c.414G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.25 pyrazinamide
clpC1 4040330 c.375C>G synonymous_variant 0.15 pyrazinamide
clpC1 4040459 c.246C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040465 c.240T>C synonymous_variant 0.27 pyrazinamide
clpC1 4040471 c.234T>C synonymous_variant 0.28 pyrazinamide Not assoc w R - Interim
clpC1 4040477 c.228G>C synonymous_variant 0.25 pyrazinamide
clpC1 4040480 c.225T>G synonymous_variant 0.27 pyrazinamide
clpC1 4040522 c.183T>C synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040644 c.61A>C synonymous_variant 0.17 pyrazinamide
clpC1 4040654 c.51G>A synonymous_variant 0.16 pyrazinamide
clpC1 4040657 c.48T>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040695 c.10C>A synonymous_variant 0.14 pyrazinamide
clpC1 4040699 c.6C>T synonymous_variant 0.14 pyrazinamide
panD 4043883 c.399C>T synonymous_variant 0.17 pyrazinamide
panD 4043886 c.396A>G synonymous_variant 0.17 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.17 pyrazinamide
panD 4044746 c.-467_-465delGTGinsAC upstream_gene_variant 0.2 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.26 pyrazinamide
panD 4044779 c.-500_-498delCTAinsTGC upstream_gene_variant 0.27 pyrazinamide
panD 4044788 c.-507G>C upstream_gene_variant 0.28 pyrazinamide
panD 4044791 c.-510G>C upstream_gene_variant 0.28 pyrazinamide
panD 4044800 c.-519C>G upstream_gene_variant 0.3 pyrazinamide
panD 4044812 c.-531A>C upstream_gene_variant 0.27 pyrazinamide
panD 4044818 c.-538_-537delCGinsAC upstream_gene_variant 0.26 pyrazinamide
panD 4044823 c.-542G>C upstream_gene_variant 0.26 pyrazinamide
panD 4044833 c.-552A>G upstream_gene_variant 0.27 pyrazinamide
panD 4044844 c.-563T>C upstream_gene_variant 0.18 pyrazinamide
panD 4044848 c.-567T>A upstream_gene_variant 0.16 pyrazinamide
panD 4044954 c.-674_-673delCCinsAT upstream_gene_variant 0.16 pyrazinamide
panD 4044980 c.-699A>G upstream_gene_variant 0.21 pyrazinamide
panD 4044983 c.-702G>T upstream_gene_variant 0.21 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.24 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.33 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.35 pyrazinamide
panD 4045019 c.-738G>C upstream_gene_variant 0.31 pyrazinamide
panD 4045022 c.-741C>G upstream_gene_variant 0.29 pyrazinamide
panD 4045028 c.-747C>G upstream_gene_variant 0.38 pyrazinamide
panD 4045034 c.-753A>C upstream_gene_variant 0.4 pyrazinamide
panD 4045055 c.-774T>G upstream_gene_variant 0.36 pyrazinamide
panD 4045067 c.-786C>G upstream_gene_variant 0.33 pyrazinamide
panD 4045070 c.-789C>T upstream_gene_variant 0.33 pyrazinamide
panD 4045076 c.-795A>C upstream_gene_variant 0.34 pyrazinamide
panD 4045088 c.-807T>C upstream_gene_variant 0.27 pyrazinamide
panD 4045094 c.-813T>C upstream_gene_variant 0.25 pyrazinamide
panD 4045097 c.-816T>C upstream_gene_variant 0.24 pyrazinamide
panD 4045105 c.-824T>C upstream_gene_variant 0.22 pyrazinamide
panD 4045112 c.-831A>G upstream_gene_variant 0.18 pyrazinamide
panD 4045115 c.-834G>C upstream_gene_variant 0.2 pyrazinamide
glpK 4138736 c.1020C>A synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139588 c.168G>C synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139597 c.159C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139601 p.Arg52Gln missense_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4139615 c.141G>A synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
embC 4239336 c.-527_-525delTTGinsCA upstream_gene_variant 0.21 ethambutol
embC 4239341 c.-522G>C upstream_gene_variant 0.21 ethambutol
embC 4239344 c.-519G>C upstream_gene_variant 0.21 ethambutol
embC 4239350 c.-513G>C upstream_gene_variant 0.21 ethambutol
embC 4239378 c.-485T>A upstream_gene_variant 0.21 ethambutol
embC 4239383 c.-480C>G upstream_gene_variant 0.2 ethambutol
embC 4239401 c.-462A>G upstream_gene_variant 0.2 ethambutol
embC 4240654 c.792C>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4240660 c.798C>G synonymous_variant 0.25 ethambutol
embC 4240669 c.807G>C synonymous_variant 0.27 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.28 ethambutol Not assoc w R
embC 4240677 p.Gly272Ala missense_variant 0.28 ethambutol
embC 4240685 p.Thr275Ala missense_variant 0.32 ethambutol
embC 4240693 c.831T>G synonymous_variant 0.33 ethambutol
embC 4240699 c.837C>G synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embC 4240726 c.864G>C synonymous_variant 0.35 ethambutol Not assoc w R - Interim
embC 4240780 c.918T>C synonymous_variant 0.31 ethambutol
embC 4240783 c.921G>C synonymous_variant 0.31 ethambutol
embC 4240789 c.927T>C synonymous_variant 0.29 ethambutol
embC 4240819 c.957A>G synonymous_variant 0.22 ethambutol
embC 4240828 c.966G>A synonymous_variant 0.22 ethambutol
embC 4240831 c.969T>G synonymous_variant 0.22 ethambutol
embC 4240867 c.1005T>C synonymous_variant 0.17 ethambutol
embC 4241053 c.1191G>C synonymous_variant 0.19 ethambutol
embC 4241089 c.1227C>G synonymous_variant 0.23 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.23 ethambutol
embC 4241107 c.1245G>C synonymous_variant 0.3 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.31 ethambutol Not assoc w R - Interim
embC 4241146 c.1284C>G synonymous_variant 0.31 ethambutol
embC 4241158 c.1296T>C synonymous_variant 0.32 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.33 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.33 ethambutol
embC 4241170 c.1308G>C synonymous_variant 0.32 ethambutol
embC 4241173 c.1311C>T synonymous_variant 0.32 ethambutol
embC 4241179 c.1317G>A synonymous_variant 0.35 ethambutol
embC 4241203 c.1341T>C synonymous_variant 0.24 ethambutol
embC 4241206 c.1344G>C synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4241218 c.1356G>C synonymous_variant 0.17 ethambutol
embC 4241230 c.1368A>G synonymous_variant 0.16 ethambutol
embC 4241395 p.Lys511Asn missense_variant 0.16 ethambutol Uncertain significance
embC 4241449 c.1587C>G synonymous_variant 0.26 ethambutol
embC 4241453 p.Ile531Val missense_variant 0.27 ethambutol
embC 4241479 c.1617C>G synonymous_variant 0.22 ethambutol
embC 4241480 c.1618T>C synonymous_variant 0.22 ethambutol
embC 4241488 c.1626G>C synonymous_variant 0.21 ethambutol
embC 4241496 p.Ala545Gly missense_variant 0.19 ethambutol
embC 4241501 p.Ser547Thr missense_variant 0.17 ethambutol
embC 4241521 c.1659T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embC 4241572 c.1710C>G synonymous_variant 0.16 ethambutol
embC 4241578 c.1716G>C synonymous_variant 0.19 ethambutol
embC 4241584 c.1722T>C synonymous_variant 0.2 ethambutol
embC 4241587 c.1725C>G synonymous_variant 0.19 ethambutol
embC 4241591 p.Leu577Val missense_variant 0.23 ethambutol
embC 4241611 c.1749G>C synonymous_variant 0.22 ethambutol
embC 4241614 c.1752A>C synonymous_variant 0.22 ethambutol
embC 4241626 c.1764T>C synonymous_variant 0.2 ethambutol
embC 4241635 c.1773G>C synonymous_variant 0.19 ethambutol
embC 4241644 c.1782G>C synonymous_variant 0.16 ethambutol
embC 4241727 p.Phe622Tyr missense_variant 0.19 ethambutol
embC 4241741 c.1879_1881delGTCinsCG frameshift_variant&missense_variant 0.22 ethambutol
embC 4241747 p.Val629Leu missense_variant 0.19 ethambutol
embC 4241750 p.Leu630Val missense_variant 0.2 ethambutol
embC 4241755 c.1893C>G synonymous_variant 0.18 ethambutol
embC 4241770 c.1908T>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
embC 4241791 c.1929G>C synonymous_variant 0.19 ethambutol
embC 4241794 c.1932C>G synonymous_variant 0.19 ethambutol
embC 4241797 c.1935C>T synonymous_variant 0.19 ethambutol
embC 4242643 c.2781C>T synonymous_variant 0.92 ethambutol Not assoc w R
embA 4242748 c.-485A>G upstream_gene_variant 0.18 ethambutol
embA 4242754 c.-479G>C upstream_gene_variant 0.2 ethambutol
embC 4242764 p.Val968Leu missense_variant 0.2 ethambutol
embA 4242772 c.-461G>C upstream_gene_variant 0.19 ethambutol
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244582 c.1350T>C synonymous_variant 0.24 ethambutol
embA 4244585 c.1353A>G synonymous_variant 0.23 ethambutol Not assoc w R - Interim
embA 4245101 c.1869G>C synonymous_variant 0.29 ethambutol
embA 4245137 c.1905T>C synonymous_variant 0.36 ethambutol
embA 4245146 c.1914G>A synonymous_variant 0.33 ethambutol
embA 4245149 c.1917C>G synonymous_variant 0.33 ethambutol
embA 4245153 p.Ile641Val missense_variant 0.33 ethambutol
embA 4245182 c.1950T>C synonymous_variant 0.35 ethambutol
embA 4245189 c.1957C>T synonymous_variant 0.34 ethambutol
embA 4245198 p.Leu656Ile missense_variant 0.32 ethambutol
embA 4245207 c.1975T>C synonymous_variant 0.29 ethambutol
embA 4245215 c.1983A>C synonymous_variant 0.25 ethambutol
embA 4245222 c.1990_1992delTATinsCG frameshift_variant&missense_variant 0.26 ethambutol Uncertain significance
embA 4245248 c.2016G>C synonymous_variant 0.22 ethambutol
embA 4245257 c.2025A>G synonymous_variant 0.2 ethambutol
embA 4245263 c.2031A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embA 4245693 p.Ile821Val missense_variant 0.22 ethambutol
embB 4245701 c.-813G>C upstream_gene_variant 0.24 ethambutol
embB 4245704 c.-810G>C upstream_gene_variant 0.24 ethambutol
embB 4245725 c.-789A>G upstream_gene_variant 0.24 ethambutol
embB 4245726 c.-788T>C upstream_gene_variant 0.24 ethambutol
embB 4245737 c.-777A>C upstream_gene_variant 0.21 ethambutol
embB 4245740 c.-774T>C upstream_gene_variant 0.21 ethambutol
embB 4245764 c.-750G>C upstream_gene_variant 0.2 ethambutol
embA 4245772 p.Asn847Thr missense_variant 0.15 ethambutol
embB 4245842 c.-672G>C upstream_gene_variant 0.17 ethambutol
embB 4245845 c.-669T>C upstream_gene_variant 0.19 ethambutol
embB 4245851 c.-663G>C upstream_gene_variant 0.2 ethambutol
embB 4245860 c.-654C>G upstream_gene_variant 0.18 ethambutol
embA 4245885 p.Asp885Asn missense_variant 0.16 ethambutol
embA 4246235 c.3003G>A synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embA 4246242 p.Gln1004Gly missense_variant 0.2 ethambutol
embB 4246250 c.-264G>C upstream_gene_variant 0.22 ethambutol
embB 4246256 c.-258G>T upstream_gene_variant 0.23 ethambutol
embB 4246259 c.-255G>C upstream_gene_variant 0.21 ethambutol
embA 4246264 p.His1011Arg missense_variant 0.23 ethambutol
embB 4246292 c.-222A>G upstream_gene_variant 0.2 ethambutol
embA 4246305 p.Ser1025Glu missense_variant 0.19 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 0.19 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.2 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.21 ethambutol
embB 4247401 c.888T>C synonymous_variant 0.18 ethambutol
embB 4247425 c.912G>C synonymous_variant 0.24 ethambutol
embB 4247434 c.921C>G synonymous_variant 0.23 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4247440 c.927C>G synonymous_variant 0.26 ethambutol
embB 4247446 c.933C>T synonymous_variant 0.24 ethambutol
embB 4247464 c.951C>G synonymous_variant 0.35 ethambutol
embB 4247470 c.957T>C synonymous_variant 0.38 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.36 ethambutol
embB 4247497 c.984T>C synonymous_variant 0.33 ethambutol
embB 4247512 c.999T>C synonymous_variant 0.35 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.35 ethambutol
embB 4247554 c.1041T>C synonymous_variant 0.33 ethambutol
embB 4247566 c.1053C>A synonymous_variant 0.24 ethambutol
embB 4247572 c.1059A>G synonymous_variant 0.21 ethambutol
embB 4247579 p.Ala356Phe missense_variant 0.18 ethambutol
embB 4247603 c.1090C>T synonymous_variant 0.16 ethambutol
embB 4247746 c.1233C>T synonymous_variant 0.18 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.2 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.25 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.25 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.26 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.26 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.25 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.27 ethambutol
embB 4247819 c.1306_1308delGTTinsAC frameshift_variant&missense_variant 0.25 ethambutol
embB 4247830 c.1317A>G synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4247836 c.1323A>G synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4247839 c.1326G>C synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.24 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.19 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.19 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.19 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4247893 c.1380C>T synonymous_variant 0.18 ethambutol
embB 4247899 p.Met462Ile missense_variant 0.26 ethambutol
embB 4247905 c.1392G>C synonymous_variant 0.26 ethambutol Not assoc w R - Interim
embB 4247909 c.1396T>C synonymous_variant 0.27 ethambutol
embB 4247914 c.1401G>C synonymous_variant 0.29 ethambutol Not assoc w R - Interim
embB 4247932 c.1419C>G synonymous_variant 0.29 ethambutol
embB 4247940 p.Leu476Trp missense_variant 0.27 ethambutol
embB 4247945 c.1432T>C synonymous_variant 0.27 ethambutol
embB 4247951 p.Ser480Ala missense_variant 0.24 ethambutol
embB 4247956 c.1443G>C synonymous_variant 0.25 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.26 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.15 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.2 ethambutol
embB 4248085 c.1572T>C synonymous_variant 0.23 ethambutol
embB 4248097 c.1584C>G synonymous_variant 0.25 ethambutol
embB 4248130 c.1617G>C synonymous_variant 0.2 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.2 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.19 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4248172 c.1659G>C synonymous_variant 0.29 ethambutol
embB 4248199 c.1686A>G synonymous_variant 0.25 ethambutol
embB 4248200 p.Ile563Val missense_variant 0.25 ethambutol
embB 4248205 c.1692C>G synonymous_variant 0.26 ethambutol
embB 4248206 c.1693_1695delAGCinsGT frameshift_variant&missense_variant 0.26 ethambutol
embB 4248220 c.1707A>C synonymous_variant 0.31 ethambutol
embB 4248304 c.1791G>C synonymous_variant 0.41 ethambutol
embB 4248316 c.1803C>G synonymous_variant 0.42 ethambutol
embB 4248319 c.1806A>G synonymous_variant 0.41 ethambutol
embB 4248343 c.1830G>C synonymous_variant 0.26 ethambutol
embB 4248350 c.1837T>C synonymous_variant 0.26 ethambutol
embB 4248355 c.1842A>G synonymous_variant 0.25 ethambutol
embB 4248358 c.1845C>G synonymous_variant 0.24 ethambutol
embB 4248361 c.1848A>C synonymous_variant 0.24 ethambutol
embB 4248362 p.Ser617Ala missense_variant 0.23 ethambutol
embB 4248373 c.1860C>G synonymous_variant 0.28 ethambutol
embB 4248382 c.1869C>G synonymous_variant 0.26 ethambutol
embB 4248386 c.1873C>A synonymous_variant 0.24 ethambutol
embB 4248407 c.1894_1896delTTAinsGG frameshift_variant&missense_variant 0.21 ethambutol
embB 4248410 c.1897_1899delTTCinsCG frameshift_variant&missense_variant 0.21 ethambutol
embB 4248419 p.Leu636Met missense_variant 0.22 ethambutol
embB 4248425 c.1912T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4248430 c.1917T>C synonymous_variant 0.2 ethambutol
embB 4248432 p.Trp640Phe missense_variant 0.2 ethambutol
embB 4248457 c.1944T>C synonymous_variant 0.21 ethambutol
embB 4249417 c.2904A>G synonymous_variant 0.19 ethambutol
embB 4249423 p.Asp970Glu missense_variant 0.19 ethambutol Uncertain significance
embB 4249424 p.Leu971Met missense_variant 0.18 ethambutol
embB 4249429 c.2916C>T synonymous_variant 0.19 ethambutol
embB 4249432 c.2919A>G synonymous_variant 0.18 ethambutol
embB 4249441 c.2928A>G synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4249444 c.2931T>C synonymous_variant 0.16 ethambutol
embB 4249498 c.2985G>C synonymous_variant 0.17 ethambutol
embB 4249521 p.Ala1003Val missense_variant 0.2 ethambutol
embB 4249525 c.3012T>C synonymous_variant 0.21 ethambutol Not assoc w R - Interim
embB 4249529 p.Ile1006Val missense_variant 0.21 ethambutol
embB 4249532 p.Ala1007Thr missense_variant 0.21 ethambutol Uncertain significance
embB 4249537 c.3024A>G synonymous_variant 0.2 ethambutol
embB 4249543 c.3030G>C synonymous_variant 0.21 ethambutol
embB 4249546 c.3033G>A synonymous_variant 0.21 ethambutol
embB 4249558 c.3045A>C synonymous_variant 0.24 ethambutol
aftB 4267647 p.Asp397Gly missense_variant 0.96 ethambutol Not assoc w R
aftB 4268117 c.720G>C synonymous_variant 0.16 ethambutol
aftB 4268125 p.Ser238Gly missense_variant 0.17 ethambutol
aftB 4268129 c.708T>G synonymous_variant 0.17 ethambutol
aftB 4268138 c.699A>C synonymous_variant 0.2 ethambutol Not assoc w R - Interim
aftB 4268144 c.693T>C synonymous_variant 0.19 ethambutol
aftB 4268164 p.Gln225Glu missense_variant 0.21 ethambutol
aftB 4268169 p.Ala223Gly missense_variant 0.19 ethambutol
aftB 4268171 c.666G>C synonymous_variant 0.17 ethambutol
aftB 4268985 c.-149A>G upstream_gene_variant 0.21 ethambutol
aftB 4268994 c.-158T>G upstream_gene_variant 0.26 ethambutol
ubiA 4268999 c.835C>T synonymous_variant 0.29 ethambutol Not assoc w R - Interim
aftB 4269006 c.-170T>C upstream_gene_variant 0.32 ethambutol
aftB 4269012 c.-176G>C upstream_gene_variant 0.31 ethambutol
ubiA 4269027 c.807C>T synonymous_variant 0.34 ethambutol Not assoc w R - Interim
aftB 4269033 c.-197T>C upstream_gene_variant 0.34 ethambutol
aftB 4269036 c.-200C>G upstream_gene_variant 0.33 ethambutol
aftB 4269042 c.-206G>C upstream_gene_variant 0.3 ethambutol
aftB 4269201 c.-365A>G upstream_gene_variant 0.16 ethambutol
ubiA 4269221 p.Ala205Thr missense_variant 0.15 ethambutol
ethA 4328463 c.-990G>C upstream_gene_variant 0.18 ethionamide
ethA 4328467 c.-994G>T upstream_gene_variant 0.18 ethionamide
ethA 4328470 c.-998_-997delAGinsGC upstream_gene_variant 0.19 ethionamide
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R